Provider: Silverchair Database: Oxford University Press Content: text/plain; charset="UTF-8" TY - JOUR AU - Seeber, Michele AU - Felline, Angelo AU - Raimondi, Francesco AU - Mariani, Simona AU - Fanelli, Francesca T1 - WebPSN: a web server for high-throughput investigation of structural communication in biomacromolecules T2 - Bioinformatics PY - 2014 Y1 - 2014/10/28/ DO - 10.1093/bioinformatics/btu718 JO - Bioinformatics JA - bioinformatics VL - 31 IS - 5 SP - 779 EP - 781 SN - 1367-4803 AB - Summary: We developed a mixed Protein Structure Network (PSN) and Elastic Network Model-Normal Mode Analysis (ENM-NMA)-based strategy (i.e. PSN-ENM) to investigate structural communication in biomacromolecules. The approach starts from a Protein Structure Graph and searches for all shortest communication pathways between user-specified residues. The graph is computed on a single preferably high-resolution structure. Information on system’s dynamics is supplied by ENM-NMA.The PSN–ENM methodology is made of multiple steps both in the setup and analysis stages, which may discourage inexperienced users. To facilitate its usage, we implemented WebPSN, a freely available web server that allows the user to easily setup the calculation, perform post-processing analyses and both visualize and download numerical and 3D representations of the output. Speed and accuracy make this server suitable to investigate structural communication, including allosterism, in large sets of bio-macromolecular systems.Availability and implementation: The WebPSN server is freely available at http://webpsn.hpc.unimore.it.Contact:fanelli@unimo.itSupplementary information:Supplementary data are available at Bioinformatics online. Y2 - 5/23/2019 UR - https://doi.org/10.1093/bioinformatics/btu718 ER -