psnGPCR

Press and hold down the left mouse button and move the mouse to rotate.
Press and hold down the central mouse button and move the mouse to translate.
Use the mouse wheel to zoom in or out.
Click on any atom on your molecule and the corresponding residue label will be placed beneath the viewer.

Orange: nodes, hubs and links specific of 5ht1_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of 5ht1_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	5ht1_off Int. Strength	5ht1_on Int. Strength	5ht1_off Hub1?	5ht1_on Hub1?	5ht1_off Hub2?	5ht1_on Hub2?	ConSurf1	ConSurf2
1	NT	NT	5ht1_off	36.84	0	Yes	No	Yes	No	2	2
2	7x32	NT	5ht1_off	5.34	0	No	No	Yes	No	2	2
3	7x35	NT	5ht1_off	7.06	0	No	No	Yes	No	4	2
4	1x32	NT	5ht1_off	11.43	0	No	No	Yes	No	3	2
5	2x67	NT	5ht1_off	8.22	0	No	No	Yes	No	4	2
6	1x31	1x34	5ht1_off	3.42	0	No	No	No	No	2	5
7	1x36	2x61	5ht1_off	3.17	0	No	No	No	No	6	7
8	1x43	2x58	5ht1_off	3.5	0	No	No	No	No	6	9
9	1x46	2x54	5ht1_off	6.4	0	No	No	No	No	7	7
10	1x49	7x50	5ht1_off	5.34	0	No	No	No	No	8	9
11	1x50	2x47	5ht1_off	4.69	0	No	No	No	No	9	9
12	1x52	1x56	5ht1_off	7.78	0	Yes	No	No	No	7	8
13	1x54	2x47	5ht1_off	3.25	0	No	No	No	No	7	9
14	1x56	8x50	5ht1_off	6.49	0	No	No	Yes	Yes	8	8
15	1x56	8x53	5ht1_off	3.36	0	No	No	No	No	8	8
16	2x37	2x39	5ht1_off	3.36	0	No	No	No	No	8	8
17	2x38	2x41	5ht1_off	4.17	0	No	No	No	No	6	5
18	2x39	3x50	5ht1_off	4.15	0	No	No	No	No	8	9
19	2x42	3x46	5ht1_off	4.28	0	No	No	No	No	7	9
20	2x43	7x53	5ht1_off	19.34	0	No	No	No	Yes	8	9
21	2x51	2x54	5ht1_off	4.5	0	No	No	No	No	8	7
22	2x52	2x551	5ht1_off	4.15	0	No	No	No	No	7	5
23	2x52	3x35	5ht1_off	4.76	0	No	No	No	No	7	6
24	2x53	2x56	5ht1_off	4.81	0	No	No	Yes	Yes	8	7
25	2x53	2x57	5ht1_off	4.56	0	No	No	Yes	Yes	8	7
26	2x60	3x28	5ht1_off	4.94	0	No	No	Yes	No	6	6
27	2x66	2x67	5ht1_off	3.64	0	No	No	No	No	5	4
28	3x24	E1x50	5ht1_off	3.68	0	No	No	Yes	Yes	4	8
29	3x28	3x29	5ht1_off	4.56	0	Yes	No	No	No	6	6
30	3x29	E2x50	5ht1_off	3.17	0	No	No	No	No	6	9
31	3x32	3x36	5ht1_off	4.67	0	Yes	No	No	No	8	6
32	3x34	4x53	5ht1_off	3.2	0	No	No	No	No	6	8
33	3x37	5x461	5ht1_off	5.03	0	No	No	No	No	7	7
34	3x38	4x53	5ht1_off	3.42	0	No	No	No	No	8	8
35	3x40	5x47	5ht1_off	3.77	0	Yes	No	Yes	Yes	8	8
36	3x40	Lig	5ht1_off	4.77	0	Yes	No	Yes	Yes	8	0
37	3x41	5x49	5ht1_off	4.01	0	Yes	Yes	No	No	6	5
38	3x42	4x50	5ht1_off	5.29	0	Yes	Yes	Yes	No	7	9
39	3x43	6x44	5ht1_off	3.65	0	No	No	Yes	Yes	8	9
40	3x44	5x54	5ht1_off	4.76	0	No	No	No	No	7	8
41	3x45	4x49	5ht1_off	3.21	0	No	No	No	No	6	7
42	3x49	3x50	5ht1_off	7.15	0	Yes	No	No	No	9	9
43	3x52	3x56	5ht1_off	4.47	0	Yes	No	No	No	5	6
44	3x54	5x68	5ht1_off	5.01	0	No	No	No	No	9	7
45	3x55	5x60	5ht1_off	6.47	0	No	No	No	No	7	6
46	3x55	5x64	5ht1_off	5.64	0	No	No	Yes	No	7	6
47	I2x52	I2x56	5ht1_off	4.05	0	No	No	No	No	5	5
48	I2x53	I2x56	5ht1_off	8.36	0	Yes	Yes	No	No	8	5
49	4x52	4x56	5ht1_off	6.28	0	No	No	No	No	5	7
50	4x54	4x58	5ht1_off	4.28	0	No	No	No	No	4	5
51	4x59	5x39	5ht1_off	5.56	0	No	No	No	No	7	8
52	4x63	E2	5ht1_off	7.64	0	No	No	Yes	Yes	6	4
53	5x44	Lig	5ht1_off	3.94	0	No	No	Yes	Yes	6	0
54	5x45	5x46	5ht1_off	3.68	0	No	No	No	No	3	4
55	5x48	6x52	5ht1_off	6.19	0	Yes	Yes	Yes	Yes	6	7
56	5x53	5x57	5ht1_off	5.54	0	No	No	No	No	7	6
57	5x54	6x41	5ht1_off	4.15	0	No	No	Yes	No	8	8
58	5x58	5x62	5ht1_off	6.95	0	Yes	Yes	Yes	No	9	6
59	5x58	6x38	5ht1_off	5.79	0	Yes	Yes	No	No	9	6
60	5x62	6x31	5ht1_off	5.14	0	Yes	No	Yes	No	6	6
61	5x64	5x67	5ht1_off	4.31	0	Yes	No	No	No	6	5
62	5x64	5x68	5ht1_off	8.14	0	Yes	No	No	No	6	7
63	5x66	5x69	5ht1_off	6.26	0	No	Yes	No	Yes	6	5
64	5x66	6x31	5ht1_off	13.86	0	No	Yes	Yes	No	6	6
65	6x26	6x29	5ht1_off	21.09	0	No	No	No	No	4	7
66	6x31	6x32	5ht1_off	3.71	0	Yes	No	No	No	6	8
67	6x44	6x45	5ht1_off	3.77	0	Yes	Yes	No	No	9	6
68	6x44	7x45	5ht1_off	8.46	0	Yes	Yes	Yes	No	9	9
69	6x48	7x42	5ht1_off	3.86	0	Yes	Yes	Yes	Yes	7	7
70	6x49	6x50	5ht1_off	3.28	0	Yes	No	No	No	6	9
71	6x51	7x34	5ht1_off	3.22	0	Yes	Yes	No	No	8	4
72	6x54	7x30	5ht1_off	3.98	0	No	Yes	No	No	4	4
73	6x58	6x59	5ht1_off	3.35	0	Yes	No	No	No	4	5
74	6x58	7x30	5ht1_off	3.94	0	Yes	No	No	No	4	4
75	6x58	7x34	5ht1_off	12.44	0	Yes	No	No	No	4	4
76	6x61	7x30	5ht1_off	7.37	0	No	No	No	No	6	4
77	7x33	7x36	5ht1_off	7.54	0	No	No	No	No	4	5
78	7x37	7x40	5ht1_off	3.65	0	Yes	Yes	No	No	6	7
79	7x38	7x42	5ht1_off	6.24	0	No	No	Yes	Yes	6	7
80	7x48	7x51	5ht1_off	4.42	0	Yes	No	No	No	6	7
81	7x53	8x50	5ht1_off	4.13	0	No	Yes	Yes	Yes	9	8
82	8x51	8x55	5ht1_off	3.93	0	No	No	No	No	9	5
83	5x61	6x34	5ht1_off	3.04	0	No	No	No	No	9	8
84	2x62	E1x51	5ht1_off	3.01	0	No	No	No	No	5	4
85	1x60	I1x49	5ht1_off	3	0	No	No	No	No	7	6
86	6x55	6x56	5ht1_off	3	0	No	No	No	No	6	6
87	1x57	2x40	5ht1_off	2.96	0	No	No	No	No	8	9
88	5x58	5x59	5ht1_off	2.9	0	Yes	Yes	No	No	9	3
89	4x60	4x61	5ht1_off	2.89	0	No	No	No	No	7	7
90	2x51	2x55	5ht1_off	2.85	0	No	No	No	No	8	5
91	3x43	6x40	5ht1_off	2.85	0	No	No	No	No	8	8
92	7x47	7x51	5ht1_off	2.85	0	No	No	No	No	6	7
93	2x40	2x43	5ht1_off	2.83	0	No	No	No	No	9	8
94	3x50	3x53	5ht1_off	2.77	0	No	No	No	No	9	7
95	5x65	6x31	5ht1_off	2.77	0	No	No	Yes	No	8	6
96	3x30	4x61	5ht1_off	2.64	0	No	No	No	No	7	7
97	1x52	7x54	5ht1_off	2.59	0	Yes	No	No	No	7	7
98	5x60	5x61	5ht1_off	2.51	0	No	No	No	No	6	9
99	8x58	CT	5ht1_off	2.51	0	No	No	No	No	6	6
100	1x52	8x57	5ht1_off	2.44	0	Yes	No	No	No	7	6
101	1x28	1x30	5ht1_off	1.78	0	No	No	No	No	6	3
102	6x41	6x42	5ht1_off	1.71	0	Yes	No	No	No	8	6
103	6x43	7x48	5ht1_off	1.62	0	No	No	Yes	No	6	6
104	6x28	6x32	5ht1_off	1.61	0	No	No	No	No	5	8
105	7x52	7x56	5ht1_off	1.55	0	Yes	Yes	No	No	8	7
106	4x40	4x44	5ht1_off	1.52	0	No	No	No	No	5	3
107	6x30	6x33	5ht1_off	1.51	0	No	No	No	No	8	8
108	2x67	E1x49	5ht1_off	1.5	0	No	No	No	No	4	3
109	4x55	4x58	5ht1_off	1.5	0	No	No	No	No	4	5
110	1x35	2x65	5ht1_off	1.49	0	No	No	No	No	4	6
111	5x37	5x38	5ht1_off	1.43	0	No	No	No	No	3	3
112	5x52	5x55	5ht1_off	1.43	0	No	No	No	No	3	5
113	6x37	6x40	5ht1_off	1.43	0	No	No	No	No	8	8
114	1x29	1x32	5ht1_off	1.41	0	No	No	No	No	3	3
115	1x34	1x37	5ht1_off	1.41	0	No	No	No	No	5	4
116	6x30	6x34	5ht1_off	1.41	0	No	No	No	No	8	8
117	6x58	7x31	5ht1_off	1.41	0	Yes	No	No	No	4	2
118	1x35	1x38	5ht1_off	1.38	0	No	No	No	No	4	5
119	1x30	1x31	5ht1_off	1.35	0	No	No	No	No	3	2
120	5x62	5x63	5ht1_off	1.26	0	Yes	No	No	No	6	4
121	8x54	8x58	5ht1_off	1.26	0	No	Yes	No	No	7	6
122	3x26	3x27	5ht1_off	1.19	0	No	No	No	No	6	5
123	5x58	6x35	5ht1_off	1.19	0	Yes	Yes	No	No	9	8
124	1x58	1x59	5ht1_off	1.03	0	No	No	No	No	3	6
125	5x40	Lig	5ht1_off	0.98	0	No	No	Yes	Yes	6	0
126	1x29	1x30	Shared	3.28	0.42	No	No	No	No	3	3
127	1x32	2x65	Shared	4.55	0.800278	No	No	No	No	3	6
128	1x36	2x65	Shared	4.81	2.81528	No	No	No	No	6	6
129	1x39	2x61	Shared	5.9	5.7025	No	Yes	No	No	6	7
130	1x39	7x39	Shared	26.19	14.5836	No	Yes	Yes	Yes	6	6
131	1x43	2x57	Shared	10.54	6.86583	No	No	Yes	Yes	6	7
132	1x45	7x47	Shared	4.73	3.33056	No	No	No	No	5	6
133	1x46	2x57	Shared	9.03	3.69056	No	No	Yes	Yes	7	7
134	1x46	7x47	Shared	4.42	7.58028	No	No	No	No	7	6
135	1x47	2x54	Shared	7.99	3.22944	No	No	No	No	6	7
136	1x50	2x50	Shared	6.73	8.75111	No	No	Yes	Yes	9	9
137	1x50	7x50	Shared	13.03	6.56472	No	No	No	No	9	9
138	1x52	8x54	Shared	5.36	3.6425	Yes	No	No	Yes	7	7
139	1x53	2x47	Shared	3.39	2.545	No	No	No	No	9	9
140	1x54	2x48	Shared	4.61	3.74861	No	No	No	No	7	6
141	1x60	I1x50	Shared	10.32	7.33361	No	No	No	Yes	7	8
142	I1x48	I1x51	Shared	5.64	2.51056	No	No	No	No	6	8
143	8x49	I1x50	Shared	4.07	3.71667	No	No	No	Yes	6	8
144	2x41	I1x51	Shared	4.36	7.45	No	No	No	No	5	8
145	2x37	2x40	Shared	7.31	8.90611	No	No	No	No	8	9
146	2x38	I2x57	Shared	4.32	4.98611	No	No	No	Yes	6	7
147	2x38	4x39	Shared	9.74	2.14694	No	No	No	No	6	3
148	2x41	4x39	Shared	4.17	3.53583	No	No	No	No	5	3
149	2x42	3x49	Shared	4.07	3.61917	No	No	Yes	No	7	9
150	2x45	3x42	Shared	12.55	8.94889	No	No	Yes	Yes	9	7
151	2x45	4x46	Shared	9.29	9.93583	No	No	No	No	9	7
152	2x46	2x50	Shared	4.07	4.485	No	Yes	Yes	Yes	9	9
153	2x46	3x43	Shared	4.15	4.38472	No	Yes	No	No	9	8
154	2x49	3x38	Shared	3.36	4.65583	No	No	No	No	8	8
155	2x49	3x42	Shared	5.48	6.58167	No	No	Yes	Yes	8	7
156	2x49	4x50	Shared	10.92	4.75083	No	No	Yes	No	8	9
157	2x50	7x46	Shared	8.83	7.97583	Yes	Yes	No	No	9	9
158	2x50	7x49	Shared	6.73	5.23639	Yes	Yes	No	Yes	9	9
159	2x52	4x50	Shared	3.42	2.30139	No	No	Yes	No	7	9
160	2x53	7x46	Shared	8.08	4.26472	No	No	No	No	8	9
161	2x551	3x31	Shared	4.5	3.28694	No	No	No	No	5	5
162	2x56	3x28	Shared	4.9	4.46306	Yes	Yes	Yes	No	7	6
163	2x56	3x32	Shared	13.15	7.22083	Yes	Yes	Yes	No	7	8
164	2x56	7x42	Shared	5.05	3.96167	Yes	Yes	Yes	Yes	7	7
165	2x57	7x39	Shared	5.82	5.485	Yes	Yes	Yes	Yes	7	6
166	2x59	3x28	Shared	14.09	11.7775	No	No	Yes	No	6	6
167	2x60	7x39	Shared	8.65	4.93305	No	No	Yes	Yes	6	6
168	2x60	7x42	Shared	6.36	4.21667	No	No	Yes	Yes	6	7
169	2x61	7x39	Shared	4.85	4.84639	No	No	Yes	Yes	7	6
170	2x62	E1x52	Shared	4.24	1.38111	No	No	No	No	5	6
171	2x63	E1x50	Shared	8.68	8.27972	No	No	Yes	Yes	6	8
172	2x63	E2	Shared	5.61	4.2075	No	No	Yes	Yes	6	4
173	2x64	7x39	Shared	9.7	3.29222	No	No	Yes	Yes	5	6
174	E1x50	E1x52	Shared	12.53	7.91056	Yes	Yes	No	No	8	6
175	3x25	E1x50	Shared	5.22	5.8775	No	No	Yes	Yes	9	8
176	3x28	E1x50	Shared	10.31	8.37194	Yes	No	Yes	Yes	6	8
177	E1x50	E2x50	Shared	15.67	12.1517	Yes	Yes	No	No	8	9
178	3x24	E1x52	Shared	7.45	6.65194	No	No	No	No	4	6
179	3x25	E2x50	Shared	7.28	7.12833	No	No	No	No	9	9
180	3x26	4x61	Shared	13.14	2.00361	No	No	No	No	6	7
181	3x30	4x57	Shared	6.52	2.05083	No	No	No	No	7	7
182	3x32	7x42	Shared	11.49	9.67306	Yes	No	Yes	Yes	8	7
183	3x32	Lig	Shared	11.78	13.5931	Yes	No	Yes	Yes	8	0
184	3x33	Lig	Shared	4.77	10.6494	No	No	Yes	Yes	6	0
185	3x34	4x57	Shared	4.8	4.9075	No	No	No	No	6	7
186	3x36	6x48	Shared	3.92	5.36694	No	No	Yes	Yes	6	7
187	3x36	Lig	Shared	5.3	9.07722	No	No	Yes	Yes	6	0
188	3x37	4x53	Shared	6.4	4.72611	No	No	No	No	7	8
189	3x37	Lig	Shared	4.92	3.24528	No	No	Yes	Yes	7	0
190	3x38	4x50	Shared	5.19	13.13	No	No	Yes	No	8	9
191	3x40	5x50	Shared	5.08	3.34278	Yes	No	No	No	8	9
192	3x40	6x44	Shared	11.3	4.53472	Yes	No	Yes	Yes	8	9
193	3x41	3x44	Shared	5.22	3.08444	Yes	Yes	No	No	6	7
194	3x41	4x49	Shared	3.68	3.83472	Yes	Yes	No	No	6	7
195	3x41	4x52	Shared	14.03	10.7944	Yes	Yes	No	No	6	5
196	3x41	5x50	Shared	13.51	6.60194	Yes	Yes	No	No	6	9
197	3x42	4x46	Shared	7.95	5.04528	Yes	Yes	No	No	7	7
198	3x42	4x49	Shared	13.84	9.62	Yes	Yes	No	No	7	7
199	3x44	5x53	Shared	3.17	3.41611	No	No	No	No	7	7
200	3x45	4x45	Shared	9.13	4.04583	No	No	No	No	6	6
201	3x48	3x52	Shared	17.08	8.83167	No	No	Yes	No	6	5
202	3x49	I2x53	Shared	9.2	7.18417	Yes	No	Yes	Yes	9	8
203	3x49	I2x57	Shared	10.72	10.9508	Yes	No	No	Yes	9	7
204	3x51	3x52	Shared	4.82	3.7125	Yes	Yes	Yes	No	8	5
205	3x51	3x55	Shared	3.75	13.8711	Yes	Yes	No	No	8	7
206	3x51	5x57	Shared	3.52	6.18472	Yes	Yes	No	No	8	6
207	3x51	5x60	Shared	12.35	10.6944	Yes	Yes	No	No	8	6
208	3x52	I2x53	Shared	18.33	12.8117	Yes	No	Yes	Yes	5	8
209	3x54	5x64	Shared	4.1	1.62	No	No	Yes	No	9	6
210	3x56	I2x52	Shared	6.5	5.1175	No	No	No	No	6	5
211	I2x53	I2x57	Shared	17.49	13.9772	Yes	Yes	No	Yes	8	7
212	4x38	4x39	Shared	5.25	2.1875	No	No	No	No	8	3
213	4x38	4x40	Shared	4.5	2.155	No	No	No	No	8	5
214	4x59	4x60	Shared	5.84	5.84	No	No	No	No	7	7
215	4x63	5x36	Shared	14.81	7.4575	No	No	No	No	6	6
216	E2	E2	Shared	15.81	18.3667	Yes	Yes	Yes	Yes	4	4
217	E2	E2x51	Shared	4.28	3.96806	Yes	Yes	No	No	4	3
218	E2x52	Lig	Shared	3.98	7.98361	No	No	Yes	Yes	6	0
219	5x44	5x48	Shared	6.24	3.81722	No	No	Yes	Yes	6	6
220	5x45	5x48	Shared	6.31	4.68722	No	No	Yes	Yes	3	6
221	5x47	5x48	Shared	11.35	5.07083	Yes	Yes	Yes	Yes	8	6
222	5x47	5x51	Shared	7.78	9.24139	Yes	Yes	No	No	8	6
223	5x47	6x49	Shared	3.65	6.46028	Yes	Yes	Yes	No	8	6
224	5x47	6x52	Shared	33.22	19.4972	Yes	Yes	Yes	Yes	8	7
225	5x48	6x56	Shared	4.69	4.78639	Yes	Yes	No	No	6	6
226	5x49	5x50	Shared	5.78	3.67167	No	No	No	No	5	9
227	5x51	6x44	Shared	5.19	3.45972	No	No	Yes	Yes	6	9
228	5x55	6x41	Shared	5.71	3.6925	No	No	Yes	No	5	8
229	5x58	6x41	Shared	3.52	3.88972	Yes	Yes	Yes	No	9	8
230	5x62	5x66	Shared	4.12	7.35695	Yes	No	No	Yes	6	6
231	6x36	7x56	Shared	7.99	9.68167	No	No	No	No	8	7
232	6x40	7x52	Shared	5.89	3.48833	No	No	Yes	Yes	8	8
233	6x45	6x49	Shared	4.28	3.91417	No	No	Yes	No	6	6
234	6x47	7x45	Shared	9.45	7.09667	No	No	Yes	No	7	9
235	6x48	6x51	Shared	9.02	4.59306	Yes	Yes	Yes	Yes	7	8
236	6x48	6x52	Shared	6.01	7.34861	Yes	Yes	Yes	Yes	7	7
237	6x48	7x41	Shared	12.67	8.20611	Yes	Yes	No	No	7	7
238	6x48	7x45	Shared	3.39	10.4211	Yes	Yes	Yes	No	7	9
239	6x48	Lig	Shared	17.49	3.9975	Yes	Yes	Yes	Yes	7	0
240	6x49	6x53	Shared	7.14	2.26028	Yes	No	No	No	6	6
241	6x50	7x37	Shared	10.11	3.6425	No	No	Yes	Yes	9	6
242	6x51	6x52	Shared	10.72	3.63417	Yes	Yes	Yes	Yes	8	7
243	6x51	7x38	Shared	7.78	4.21833	Yes	Yes	No	No	8	6
244	6x51	Lig	Shared	15.45	13.7783	Yes	Yes	Yes	Yes	8	0
245	6x52	Lig	Shared	13.83	8.96861	Yes	Yes	Yes	Yes	7	0
246	6x54	7x34	Shared	5.02	3.1025	No	Yes	No	No	4	4
247	6x54	7x37	Shared	3.77	5.21861	No	Yes	Yes	Yes	4	6
248	7x36	7x37	Shared	7.5	2.69667	No	No	Yes	Yes	5	6
249	7x39	7x42	Shared	6.75	8.94917	Yes	Yes	Yes	Yes	6	7
250	7x42	Lig	Shared	4.7	6.3175	Yes	Yes	Yes	Yes	7	0
251	7x43	7x48	Shared	5.71	4.13667	No	No	Yes	No	4	6
252	7x45	7x49	Shared	13.62	10.9731	Yes	No	No	Yes	9	9
253	8x47	8x49	Shared	10.77	8.88833	No	No	No	No	9	6
254	8x47	8x50	Shared	7.25	8.38944	No	No	Yes	Yes	9	8
255	8x48	8x51	Shared	9.45	4.5375	No	No	No	No	6	9
256	8x48	8x52	Shared	3.82	0.473056	No	No	No	No	6	4
257	8x55	CT	Shared	16.97	0.363333	No	No	No	No	5	6
258	2x42	4x42	Shared	3.15	2.27778	No	No	No	No	7	7
259	3x47	5x57	Shared	3.15	2.88806	No	No	No	No	9	6
260	4x41	I2x53	Shared	3.09	4.4675	No	No	Yes	Yes	6	8
261	3x34	4x54	Shared	3.04	3.87194	No	No	No	No	6	4
262	5x43	Lig	Shared	3.01	5.05083	No	No	Yes	Yes	7	0
263	4x44	4x48	Shared	2.98	1.37333	No	No	No	No	3	2
264	2x50	3x39	Shared	2.94	2.77889	Yes	Yes	No	No	9	9
265	7x48	7x52	Shared	2.94	2.96056	Yes	No	Yes	Yes	6	8
266	2x55	2x551	Shared	2.85	3.03028	No	No	No	No	5	5
267	3x21	E1x50	Shared	2.81	1.71889	No	No	Yes	Yes	6	8
268	1x55	1x59	Shared	2.77	1.19278	No	No	No	No	4	6
269	3x23	3x27	Shared	2.62	1.28361	No	No	No	No	1	5
270	7x54	8x50	Shared	2.59	10.2408	No	No	Yes	Yes	7	8
271	7x54	8x54	Shared	2.59	4.215	No	No	No	Yes	7	7
272	5x36	5x38	Shared	2.57	2.17889	No	No	No	No	6	3
273	4x56	5x42	Shared	2.42	2.92028	No	No	No	No	7	4
274	1x42	7x39	Shared	2.35	2.39167	No	No	Yes	Yes	6	6
275	6x57	6x61	Shared	1.71	1.6125	No	No	No	No	5	6
276	1x57	2x44	Shared	1.7	4.20333	No	No	No	No	8	6
277	5x69	6x27	Shared	1.62	1.0875	No	Yes	No	No	5	5
278	6x43	7x52	Shared	1.62	2.92139	No	No	Yes	Yes	6	8
279	5x41	5x45	Shared	1.6	4.41778	No	No	No	No	5	3
280	1x48	1x49	Shared	1.5	1.235	No	No	No	No	4	8
281	1x29	1x33	Shared	1.49	0.486667	No	No	No	No	3	5
282	6x39	7x52	Shared	1.47	3.3125	No	No	Yes	Yes	7	8
283	1x50	2x51	5ht1_on	0	5.13972	No	No	No	No	9	8
284	1x53	7x54	5ht1_on	0	3.46444	No	No	No	No	9	7
285	1x56	8x54	5ht1_on	0	4.52444	No	No	No	Yes	8	7
286	1x57	8x50	5ht1_on	0	5.405	No	No	Yes	Yes	8	8
287	1x60	8x53	5ht1_on	0	4.62583	No	No	No	No	7	8
288	1x60	8x56	5ht1_on	0	4.22833	No	No	No	No	7	5
289	2x40	I1x50	5ht1_on	0	5.56972	No	No	No	Yes	9	8
290	8x50	I1x50	5ht1_on	0	8.86472	Yes	Yes	No	Yes	8	8
291	2x39	I2x57	5ht1_on	0	3.53361	No	No	No	Yes	8	7
292	2x40	8x50	5ht1_on	0	7.41833	No	No	Yes	Yes	9	8
293	2x46	3x42	5ht1_on	0	4.855	No	Yes	Yes	Yes	9	7
294	2x46	3x46	5ht1_on	0	3.28778	No	Yes	No	No	9	9
295	2x46	7x49	5ht1_on	0	6.94194	No	Yes	No	Yes	9	9
296	2x53	3x35	5ht1_on	0	3.41722	No	No	No	No	8	6
297	2x57	7x42	5ht1_on	0	3.89083	Yes	Yes	Yes	Yes	7	7
298	2x64	7x35	5ht1_on	0	4.46194	No	No	No	No	5	4
299	E1x49	E1x51	5ht1_on	0	5.90167	No	No	No	No	3	4
300	E1x49	E2	5ht1_on	0	5.04944	No	No	Yes	Yes	3	4
301	3x22	E2	5ht1_on	0	3.46111	No	No	Yes	Yes	4	4
302	3x33	4x57	5ht1_on	0	6.10028	No	No	No	No	6	7
303	3x37	4x56	5ht1_on	0	5.95333	No	No	No	No	7	7
304	3x38	3x42	5ht1_on	0	5.40444	No	No	Yes	Yes	8	7
305	3x40	6x48	5ht1_on	0	7.17695	Yes	No	Yes	Yes	8	7
306	3x43	7x49	5ht1_on	0	9.99111	No	No	No	Yes	8	9
307	3x43	7x53	5ht1_on	0	6.73778	No	No	No	Yes	8	9
308	3x46	3x50	5ht1_on	0	5.56694	No	No	No	No	9	9
309	3x46	7x53	5ht1_on	0	5.30389	No	No	No	Yes	9	9
310	3x47	5x58	5ht1_on	0	4.29944	No	No	Yes	Yes	9	9
311	3x48	5x57	5ht1_on	0	5.92139	No	No	No	No	6	6
312	3x50	5x58	5ht1_on	0	5.62806	No	No	Yes	Yes	9	9
313	3x50	7x53	5ht1_on	0	7.40083	No	No	No	Yes	9	9
314	3x51	5x61	5ht1_on	0	3.36111	Yes	Yes	No	No	8	9
315	4x41	4x45	5ht1_on	0	4.51889	No	No	No	No	6	6
316	4x58	4x59	5ht1_on	0	3.32556	No	No	No	No	5	7
317	4x60	5x39	5ht1_on	0	9.42833	No	No	No	No	7	8
318	6x59	E2	5ht1_on	0	4.15111	No	No	Yes	Yes	5	4
319	5x37	6x60	5ht1_on	0	5.10778	No	No	No	No	3	6
320	5x39	5x43	5ht1_on	0	6.18222	No	No	No	No	8	7
321	5x40	6x59	5ht1_on	0	4.82556	No	No	No	No	6	5
322	5x44	6x56	5ht1_on	0	6.34667	No	No	No	No	6	6
323	5x47	6x44	5ht1_on	0	7.65139	Yes	Yes	Yes	Yes	8	9
324	5x51	5x55	5ht1_on	0	3.2325	No	No	No	No	6	5
325	5x54	5x58	5ht1_on	0	4.28528	No	No	Yes	Yes	8	9
326	5x54	6x44	5ht1_on	0	3.89028	No	No	Yes	Yes	8	9
327	5x56	5x60	5ht1_on	0	4.58861	No	No	No	No	4	6
328	5x58	6x37	5ht1_on	0	4.26361	Yes	Yes	No	No	9	8
329	5x58	6x40	5ht1_on	0	8.52972	Yes	Yes	No	No	9	8
330	5x62	6x34	5ht1_on	0	4.17222	Yes	No	No	No	6	8
331	5x62	6x37	5ht1_on	0	3.65417	Yes	No	No	No	6	8
332	5x66	5x70	5ht1_on	0	5.19972	No	Yes	No	No	6	0
333	5x66	6x30	5ht1_on	0	7.44972	No	Yes	No	No	6	8
334	5x69	6x30	5ht1_on	0	6.96333	No	Yes	No	No	5	8
335	5x70	6x30	5ht1_on	0	4.72694	No	No	No	No	0	8
336	6x25	6x29	5ht1_on	0	4.43083	No	No	No	No	0	7
337	6x40	7x53	5ht1_on	0	4.60222	No	No	No	Yes	8	9
338	6x44	6x48	5ht1_on	0	5.54222	Yes	Yes	Yes	Yes	9	7
339	6x51	6x55	5ht1_on	0	4.2125	Yes	Yes	No	No	8	6
340	6x54	E3	5ht1_on	0	3.56472	No	Yes	No	Yes	4	4
341	6x58	E3	5ht1_on	0	7.47361	Yes	No	No	Yes	4	4
342	E3	E3	5ht1_on	0	3.94056	No	Yes	No	Yes	4	4
343	7x33	E3	5ht1_on	0	3.33611	No	No	No	Yes	4	4
344	7x49	7x53	5ht1_on	0	3.52083	No	Yes	No	Yes	9	9
345	7x52	7x53	5ht1_on	0	3.71389	Yes	Yes	No	Yes	8	9
346	8x50	8x54	5ht1_on	0	4.37611	Yes	Yes	No	Yes	8	7
347	3x22	3x26	5ht1_on	0	5.395	No	No	No	No	4	6
348	3x55	3x56	5ht1_on	0	4.46444	No	No	No	No	7	6
349	5x36	E2	5ht1_on	0	7.49861	No	No	Yes	Yes	6	4
350	6x32	6x36	5ht1_on	0	4.81	No	No	No	No	8	8
351	6x55	Lig	5ht1_on	0	7.34028	No	No	Yes	Yes	6	0
352	7x33	7x37	5ht1_on	0	3.79889	No	No	Yes	Yes	4	6
353	1x35	1x39	5ht1_on	0	3.3475	No	No	No	Yes	4	6
354	I3	I3	5ht1_on	0	5.6175	No	Yes	No	Yes	0	0
355	7x55	7x56	5ht1_on	0	4.73083	No	No	No	No	5	7
356	6x51	6x54	5ht1_on	0	3.20417	Yes	Yes	No	Yes	8	4
357	3x29	E2x52	5ht1_on	0	3.1675	No	No	No	No	6	6
358	4x51	4x55	5ht1_on	0	3.16361	No	No	No	No	4	4
359	4x41	I2x56	5ht1_on	0	3.16306	No	No	No	No	6	5
360	8x49	I1x49	5ht1_on	0	3.1125	No	No	No	No	6	6
361	5x461	Lig	5ht1_on	0	3.08222	No	No	Yes	Yes	7	0
362	I2x51	I2x52	5ht1_on	0	3.05083	No	No	No	No	6	5
363	5x59	5x63	5ht1_on	0	3.03583	No	No	No	No	3	4
364	2x54	2x57	5ht1_on	0	3.015	No	No	Yes	Yes	7	7
365	6x61	E3	5ht1_on	0	3.01417	No	No	No	Yes	6	4
366	7x30	7x33	5ht1_on	0	2.96583	No	No	No	No	4	4
367	2x43	8x50	5ht1_on	0	2.96528	No	No	Yes	Yes	8	8
368	5x46	5x49	5ht1_on	0	2.94028	No	No	No	No	4	5
369	2x65	2x66	5ht1_on	0	2.88444	No	No	No	No	6	5
370	3x53	I2x57	5ht1_on	0	2.84333	No	No	No	Yes	7	7
371	1x56	8x57	5ht1_on	0	2.7825	No	No	No	No	8	6
372	7x31	7x35	5ht1_on	0	2.6675	No	No	No	No	2	4
373	3x54	5x61	5ht1_on	0	2.61722	No	No	No	No	9	9
374	5x68	5x72	5ht1_on	0	2.46583	No	No	No	No	7	0
375	6x50	7x40	5ht1_on	0	2.41778	No	No	No	No	9	7
376	1x53	7x50	5ht1_on	0	2.3075	No	No	No	No	9	9
377	1x59	8x57	5ht1_on	0	2.27611	No	No	No	No	6	6
378	4x62	E2	5ht1_on	0	2.2625	No	No	Yes	Yes	6	4
379	2x56	3x31	5ht1_on	0	2.24	Yes	Yes	No	No	7	5
380	7x55	8x54	5ht1_on	0	2.23472	No	No	No	Yes	5	7
381	5x41	6x60	5ht1_on	0	2.18472	No	No	No	No	5	6
382	2x66	E1x49	5ht1_on	0	2.16083	No	No	No	No	5	3
383	5x69	6x29	5ht1_on	0	2.1425	No	Yes	No	No	5	7
384	6x14	6x16	5ht1_on	0	2.1375	No	No	No	No	0	0
385	8x47	8x48	5ht1_on	0	2.11972	No	No	No	No	9	6
386	5x73	I3	5ht1_on	0	2.0525	No	No	No	Yes	0	0
387	6x42	6x45	5ht1_on	0	2.04528	No	No	No	No	6	6
388	7x30	7x32	5ht1_on	0	1.97639	No	No	No	No	4	2
389	5x67	5x70	5ht1_on	0	1.95333	No	No	No	No	5	0
390	6x35	6x39	5ht1_on	0	1.93833	No	No	No	No	8	7
391	1x54	2x44	5ht1_on	0	1.79083	No	No	No	No	7	6
392	6x31	6x35	5ht1_on	0	1.7775	Yes	No	No	No	6	8
393	1x40	1x44	5ht1_on	0	1.765	No	No	No	No	3	5
394	6x20	6x23	5ht1_on	0	1.74472	No	No	No	No	0	0
395	2x57	2x58	5ht1_on	0	1.67	Yes	Yes	No	No	7	9
396	4x48	4x52	5ht1_on	0	1.63333	No	No	No	No	2	5
397	1x38	1x39	5ht1_on	0	1.60417	No	No	No	Yes	5	6
398	1x44	1x48	5ht1_on	0	1.41722	No	No	No	No	5	4
399	1x33	1x37	5ht1_on	0	1.40444	No	No	No	No	5	4
400	1x54	1x58	5ht1_on	0	1.385	No	No	No	No	7	3
401	5x68	I3	5ht1_on	0	1.285	No	No	No	Yes	7	0
402	1x31	1x32	5ht1_on	0	1.27917	No	No	No	No	2	3
403	2x67	7x35	5ht1_on	0	1.26	No	No	No	No	4	4
404	1x29	NT	5ht1_on	0	1.24	No	No	Yes	No	3	2
405	5x71	5x72	5ht1_on	0	1.2325	No	No	No	No	0	0
406	5x69	6x26	5ht1_on	0	1.18028	No	Yes	No	No	5	4
407	I2x55	I2x56	5ht1_on	0	1.16417	No	No	No	No	5	5
408	1x51	2x51	5ht1_on	0	1.16306	No	No	No	No	4	8
409	3x27	3x30	5ht1_on	0	1.16	No	No	No	No	5	7
410	1x41	1x44	5ht1_on	0	1.12	No	No	No	No	4	5
411	1x34	1x35	5ht1_on	0	1.1175	No	No	No	No	5	4
412	5x63	5x66	5ht1_on	0	1.05111	No	No	No	Yes	4	6
413	5x69	6x33	5ht1_on	0	1.00444	No	Yes	No	No	5	8
414	1x49	1x52	5ht1_on	0	0.984722	No	No	Yes	No	8	7
415	1x52	8x58	5ht1_on	0	0.9825	Yes	No	No	No	7	6
416	4x64	5x39	5ht1_on	0	0.964722	No	No	No	No	0	8
417	5x67	5x71	5ht1_on	0	0.964722	No	No	No	No	5	0
418	1x49	7x51	5ht1_on	0	0.9225	No	No	No	No	8	7
419	I2x54	I2x55	5ht1_on	0	0.888056	No	No	No	No	6	5
420	4x47	4x48	5ht1_on	0	0.885	No	No	No	No	3	2
421	5x65	5x69	5ht1_on	0	0.85	No	No	No	Yes	8	5
422	4x55	5x42	5ht1_on	0	0.778333	No	No	No	No	4	4
423	6x37	6x38	5ht1_on	0	0.76	No	No	No	No	8	6
424	1x28	1x31	5ht1_on	0	0.6925	No	No	No	No	6	2
425	3x56	I2x50	5ht1_on	0	0.670833	No	No	No	No	6	8
426	6x20	6x24	5ht1_on	0	0.6375	No	No	No	No	0	0
427	5x52	5x56	5ht1_on	0	0.628333	No	No	No	No	3	4
428	4x65	E2	5ht1_on	0	0.6175	No	No	Yes	Yes	0	4
429	6x45	6x46	5ht1_on	0	0.605	No	No	No	No	6	5
430	8x52	8x55	5ht1_on	0	0.544444	No	No	No	No	4	5
431	6x19	6x23	5ht1_on	0	0.538056	No	No	No	No	0	0
432	6x28	6x31	5ht1_on	0	0.536667	No	No	Yes	No	5	6
433	4x40	4x43	5ht1_on	0	0.525833	No	No	No	No	5	3
434	6x14	6x17	5ht1_on	0	0.481111	No	No	No	No	0	0
435	6x23	6x27	5ht1_on	0	0.472222	No	No	No	No	0	5
436	1x32	1x33	5ht1_on	0	0.36	No	No	No	No	3	5
437	6x22	6x25	5ht1_on	0	0.32	No	No	No	No	0	0
438	6x18	6x22	5ht1_on	0	0.194444	No	No	No	No	0	0
439	6x14	6x15	5ht1_on	0	0.194167	No	No	No	No	0	0
440	6x16	6x20	5ht1_on	0	0.105833	No	No	No	No	0	0
441	6x21	6x24	5ht1_on	0	0.0447222	No	No	No	No	0	0

Orange: nodes, hubs and links specific of 5ht1_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of 5ht1_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	5ht1_off Avg Int. Strength	5ht1_on Avg Int. Strength	5ht1_off Num Of Links	5ht1_on Num Of Links	ConSurf
1	NT	5ht1_off	17.6217	1.24	6	1	2
2	1x52	5ht1_off	4.5425	1.86991	4	3	7
3	3x28	5ht1_off	7.76	8.20417	5	3	6
4	3x32	5ht1_off	10.2725	10.1623	4	3	8
5	3x40	5ht1_off	6.23	5.01815	4	3	8
6	3x49	5ht1_off	7.785	7.25139	4	3	9
7	3x52	5ht1_off	11.175	8.45194	4	3	5
8	4x50	5ht1_off	6.205	6.72741	4	3	9
9	5x62	5ht1_off	4.3675	5.06111	4	3	6
10	5x64	5ht1_off	5.5475	1.62	4	1	6
11	6x31	5ht1_off	6.37	1.15708	4	2	6
12	6x41	5ht1_off	3.7725	3.79111	4	2	8
13	6x49	5ht1_off	4.5875	4.21157	4	3	6
14	6x58	5ht1_off	5.285	7.47361	4	1	4
15	7x45	5ht1_off	8.73	9.49694	4	3	9
16	7x48	5ht1_off	3.6725	3.54861	4	2	6
17	2x50	Shared	5.86	5.84544	5	5	9
18	2x56	Shared	6.9775	4.47139	4	4	7
19	2x57	Shared	7.4875	4.10287	4	6	7
20	E1x50	Shared	8.41429	7.38505	7	6	8
21	3x41	Shared	8.09	6.07889	5	4	6
22	3x42	Shared	9.022	6.74255	5	6	7
23	3x51	Shared	6.11	7.56478	4	5	8
24	I2x53	Shared	11.294	9.61014	5	4	8
25	E2	Shared	9.83	6.79492	5	10	4
26	5x47	Shared	11.954	9.58422	5	5	8
27	5x48	Shared	6.956	4.59042	5	4	6
28	5x58	Shared	4.07	5.14931	5	6	9
29	6x44	Shared	6.474	5.01567	5	5	9
30	6x48	Shared	8.05143	6.58156	7	8	7
31	6x51	Shared	9.238	5.60676	5	6	8
32	6x52	Shared	13.994	9.86215	5	4	7
33	7x37	Shared	6.2575	3.83917	4	4	6
34	7x39	Shared	9.18714	6.35444	7	7	6
35	7x42	Shared	6.35	6.16815	7	6	7
36	7x52	Shared	2.694	3.27933	5	5	8
37	8x50	Shared	5.115	6.80853	4	7	8
38	Lig	Shared	7.30154	7.75699	13	12	0
39	1x39	5ht1_on	16.045	6.30944	2	4	6
40	I1x50	5ht1_on	7.195	6.37118	2	4	8
41	2x46	5ht1_on	4.11	4.79089	2	5	9
42	I2x57	5ht1_on	10.8433	7.25822	3	5	7
43	5x66	5ht1_on	8.08	5.26438	3	4	6
44	5x69	5ht1_on	3.94	2.20468	2	6	5
45	6x54	5ht1_on	4.25667	3.7725	3	4	4
46	E3	5ht1_on	0	4.21162	0	6	4
47	7x49	5ht1_on	10.175	7.33267	2	5	9
48	7x53	5ht1_on	11.735	5.21324	2	6	9
49	8x54	5ht1_on	3.07	3.79856	3	5	7
50	I3	5ht1_on	0	3.64312	0	4	0

Orange: nodes, hubs and links specific of 5ht1_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of 5ht1_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	5ht1_off Recurrence	5ht1_on Recurrence	5ht1_off Hub1?	5ht1_on Hub1?	5ht1_off Hub2?	5ht1_on Hub2?	ConSurf1	ConSurf2
1	1x29	1x32	5ht1_off	10.8065	0	No	No	No	No	3	3
2	1x36	2x65	5ht1_off	25.0641	2.00705	No	No	No	No	6	6
3	1x36	2x61	5ht1_off	26.4778	0	No	No	No	No	6	7
4	2x61	7x39	5ht1_off	27.6299	1.1001	No	No	Yes	Yes	7	6
5	2x57	7x39	5ht1_off	16.3405	0.373698	Yes	Yes	Yes	Yes	7	6
6	1x46	2x57	5ht1_off	13.7546	3.93853	No	No	Yes	Yes	7	7
7	7x53	8x50	5ht1_off	30.1555	0	No	Yes	Yes	Yes	9	8
8	2x43	7x53	5ht1_off	31.378	0	No	No	No	Yes	8	9
9	2x40	2x43	5ht1_off	32.842	0	No	No	No	No	9	8
10	2x37	2x40	5ht1_off	37.0982	2.33456	No	No	No	No	8	9
11	2x37	2x39	5ht1_off	38.4968	0	No	No	No	No	8	8
12	2x39	3x50	5ht1_off	39.6639	0	No	No	No	No	8	9
13	3x49	3x50	5ht1_off	42.436	0	Yes	No	No	No	9	9
14	3x49	I2x53	5ht1_off	45.7816	9.89671	Yes	No	Yes	Yes	9	8
15	5x53	5x57	5ht1_off	81.9238	0	No	No	No	No	7	6
16	3x44	5x53	5ht1_off	82.9401	1.54518	No	No	No	No	7	7
17	3x41	3x44	5ht1_off	100	3.08616	Yes	Yes	No	No	6	7
18	3x41	5x50	5ht1_off	88.7609	9.9303	Yes	Yes	No	No	6	9
19	3x40	Lig	5ht1_off	73.4668	0	Yes	No	Yes	Yes	8	0
20	3x38	4x53	5ht1_off	22.2871	0	No	No	No	No	8	8
21	3x37	4x53	5ht1_off	27.1721	1.478	No	No	No	No	7	8
22	3x37	Lig	5ht1_off	29.5266	8.67064	No	No	Yes	Yes	7	0
23	3x42	4x50	5ht1_off	13.4829	0	Yes	Yes	Yes	No	7	9
24	3x38	4x50	5ht1_off	12.7232	3.27931	No	No	Yes	No	8	9
25	3x42	4x49	5ht1_off	22.4631	5.03443	Yes	Yes	No	No	7	7
26	3x41	4x49	5ht1_off	25.7383	4.96305	Yes	Yes	No	No	6	7
27	3x43	6x44	5ht1_off	21.5727	0	No	No	Yes	Yes	8	9
28	3x40	6x44	5ht1_off	27.0614	6.00857	Yes	No	Yes	Yes	8	9
29	6x44	7x45	5ht1_off	11.8328	0	Yes	Yes	Yes	No	9	9
30	6x48	7x42	5ht1_off	15.8223	0	Yes	Yes	Yes	Yes	7	7
31	2x60	3x28	5ht1_off	26.1659	0	No	No	Yes	No	6	6
32	E1x50	E1x52	5ht1_off	11.4504	7.12546	Yes	Yes	No	No	8	6
33	3x30	4x61	5ht1_off	15.928	0	No	No	No	No	7	7
34	3x30	4x57	5ht1_off	18.2623	4.4172	No	No	No	No	7	7
35	3x34	4x57	5ht1_off	20.5816	2.9518	No	No	No	No	6	7
36	3x34	4x53	5ht1_off	29.758	0	No	No	No	No	6	8
37	3x40	5x47	5ht1_off	11.5762	0	Yes	No	Yes	Yes	8	8
38	3x44	5x54	5ht1_off	27.4689	0	No	No	No	No	7	8
39	4x63	E2	5ht1_off	14.8715	0	No	No	Yes	Yes	6	4
40	4x63	5x36	5ht1_off	11.4605	1.98186	No	No	No	No	6	6
41	5x54	6x41	5ht1_off	25.9898	0	No	No	Yes	No	8	8
42	5x58	6x41	5ht1_off	19.9477	3.43467	Yes	Yes	Yes	No	9	8
43	5x58	5x62	5ht1_off	13.9961	0	Yes	Yes	Yes	No	9	6
44	3x43	6x40	5ht1_off	14.2476	0	No	No	No	No	8	8
45	6x51	Lig	5ht1_off	17.7341	9.04434	Yes	Yes	Yes	Yes	8	0
46	6x54	7x34	5ht1_off	15.118	1.17568	No	Yes	No	No	4	4
47	6x51	7x34	5ht1_off	29.8536	0	Yes	Yes	No	No	8	4
48	6x58	7x34	5ht1_off	13.1358	0	Yes	No	No	No	4	4
49	6x40	7x52	5ht1_off	10.6153	3.92593	No	No	Yes	Yes	8	8
50	2x60	7x42	5ht1_off	23.3083	1.0875	No	No	Yes	Yes	6	7
51	1x32	2x65	Shared	20.7929	17.3455	No	No	No	No	3	6
52	1x50	2x50	Shared	14.3633	100	No	No	Yes	Yes	9	9
53	3x52	I2x53	Shared	63.1886	70.2763	Yes	No	Yes	Yes	5	8
54	3x51	3x52	Shared	68.1139	37.374	Yes	Yes	Yes	No	8	5
55	3x51	5x57	Shared	79.7957	56.6216	Yes	Yes	No	No	8	6
56	3x40	5x50	Shared	90.2048	13.2432	Yes	No	No	No	8	9
57	7x42	Lig	Shared	64.7432	60.8498	Yes	Yes	Yes	Yes	7	0
58	7x39	7x42	Shared	36.9472	12.8065	Yes	Yes	Yes	Yes	6	7
59	7x54	8x50	Shared	15.1381	49.7145	No	No	Yes	Yes	7	8
60	7x54	8x54	Shared	10.6404	36.3789	No	No	No	Yes	7	7
61	2x38	I2x57	Shared	14.2677	27.4731	No	No	No	Yes	6	7
62	I2x53	I2x57	Shared	14.1772	37.1851	Yes	Yes	No	Yes	8	7
63	7x45	7x49	Shared	10.5046	57.9442	Yes	No	No	Yes	9	9
64	2x56	7x42	Shared	25.8641	42.7528	Yes	Yes	Yes	Yes	7	7
65	3x28	E1x50	Shared	54.7869	70.4316	Yes	No	Yes	Yes	6	8
66	2x63	E1x50	Shared	25.4465	55.4417	No	No	Yes	Yes	6	8
67	2x63	E2	Shared	21.6632	53.2373	No	No	Yes	Yes	6	4
68	2x56	3x28	Shared	42.9642	74.2694	Yes	Yes	Yes	No	7	6
69	2x56	3x32	Shared	19.4144	39.6792	Yes	Yes	Yes	No	7	8
70	3x32	Lig	Shared	19.9678	40.4056	Yes	No	Yes	Yes	8	0
71	3x33	Lig	5ht1_on	1.51431	10.1948	No	No	Yes	Yes	6	0
72	2x50	7x49	5ht1_on	9.55376	83.7042	Yes	Yes	No	Yes	9	9
73	6x48	7x45	5ht1_on	9.18147	58.087	Yes	Yes	Yes	No	7	9
74	6x48	Lig	5ht1_on	3.13428	95.7969	Yes	Yes	Yes	Yes	7	0
75	1x50	7x50	5ht1_on	5.45857	94.0922	No	No	No	No	9	9
76	1x52	8x54	5ht1_on	0.115712	18.0215	Yes	No	No	Yes	7	7
77	1x53	7x54	5ht1_on	0	88.1088	No	No	No	No	9	7
78	1x53	7x50	5ht1_on	0	92.1061	No	No	No	No	9	9
79	1x57	8x50	5ht1_on	0	11.6476	No	No	Yes	Yes	8	8
80	8x50	I1x50	5ht1_on	0	13.8016	Yes	Yes	No	Yes	8	8
81	8x47	8x50	5ht1_on	8.11491	17.9039	No	No	Yes	Yes	9	8
82	2x41	4x39	5ht1_on	0.0704332	10.5769	No	No	No	No	5	3
83	2x38	4x39	5ht1_on	8.06963	24.5675	No	No	No	No	6	3
84	3x48	3x52	5ht1_on	1.64512	36.3579	No	No	Yes	No	6	5
85	3x48	5x57	5ht1_on	0	37.9619	No	No	No	No	6	6
86	3x47	5x57	5ht1_on	1.64512	95.9397	No	No	No	No	9	6
87	3x47	5x58	5ht1_on	0	97.3841	No	No	Yes	Yes	9	9
88	5x54	5x58	5ht1_on	0	68.3994	No	No	Yes	Yes	8	9
89	5x54	6x44	5ht1_on	0	68.202	No	No	Yes	Yes	8	9
90	6x44	6x48	5ht1_on	0	63.6421	Yes	Yes	Yes	Yes	9	7
91	2x46	3x42	5ht1_on	0	17.6184	No	Yes	Yes	Yes	9	7
92	2x46	3x46	5ht1_on	0	27.1498	No	Yes	No	No	9	9
93	E1x49	E2	5ht1_on	0	28.4725	No	No	Yes	Yes	3	4
94	7x49	7x53	5ht1_on	0	54.2954	No	Yes	No	Yes	9	9
95	4x41	I2x53	5ht1_on	1.39357	20.5114	No	No	Yes	Yes	6	8
96	5x47	6x52	5ht1_on	6.01197	13.9528	Yes	Yes	Yes	Yes	8	7
97	5x47	5x48	5ht1_on	3.94929	12.2985	Yes	Yes	Yes	Yes	8	6
98	5x58	6x37	5ht1_on	0	55.1436	Yes	Yes	No	No	9	8
99	5x58	6x40	5ht1_on	0	27.7922	Yes	Yes	No	No	9	8
100	6x40	7x53	5ht1_on	0	23.8873	No	No	No	Yes	8	9
101	5x62	6x37	5ht1_on	0	51.7299	Yes	No	No	No	6	8
102	5x62	5x66	5ht1_on	4.61337	48.3456	Yes	No	No	Yes	6	6
103	5x66	5x70	5ht1_on	0	11.824	No	Yes	No	No	6	0
104	5x66	6x30	5ht1_on	0	31.3991	No	Yes	No	No	6	8
105	5x69	6x30	5ht1_on	0	30.1772	No	Yes	No	No	5	8
106	6x51	6x54	5ht1_on	0	22.4681	Yes	Yes	No	Yes	8	4
107	6x54	7x37	5ht1_on	6.80686	10.0815	No	Yes	Yes	Yes	4	6
108	6x54	E3	5ht1_on	0	10.0857	No	Yes	No	Yes	4	4
109	8x47	8x48	5ht1_on	0	11.1732	No	No	No	No	9	6
110	4x41	I2x56	5ht1_on	0	10.5727	No	No	No	No	6	5
111	2x65	2x66	5ht1_on	0	21.6199	No	No	No	No	6	5
112	2x66	E1x49	5ht1_on	0	23.9209	No	No	No	No	5	3
113	5x67	5x70	5ht1_on	0	10.2662	No	No	No	No	5	0
114	4x38	4x39	5ht1_on	6.53519	10.5769	No	No	No	No	8	3
115	1x49	1x52	5ht1_on	0	13.9528	No	No	Yes	No	8	7
116	1x32	1x33	5ht1_on	0	11.0808	No	No	No	No	3	5
117	5x69	6x27	5ht1_on	1.40363	16.4217	No	Yes	No	No	5	5
118	3x50	5x58	5ht1_on	0	49.135	No	No	Yes	Yes	9	9
119	3x50	7x53	5ht1_on	0	23.354	No	No	No	Yes	9	9
120	6x23	6x27	5ht1_on	0	14.549	No	No	No	No	0	5
121	6x20	6x23	5ht1_on	0	11.3159	No	No	No	No	0	0
122	6x48	6x51	5ht1_on	8.33124	15.4098	Yes	Yes	Yes	Yes	7	8
123	5x47	6x44	5ht1_on	0	11.1354	Yes	Yes	Yes	Yes	8	9
124	2x46	2x50	5ht1_on	7.93882	25.9699	No	Yes	Yes	Yes	9	9
125	3x46	3x50	5ht1_on	0	25.9279	No	No	No	No	9	9

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
2x56	3x32	Shared	13.15	7.22083	1	1	2	1
2x56	7x42	Shared	5.05	3.96167	1	1	2	1
2x57	7x39	Shared	5.82	5.485	0	1	2	2
2x60	7x39	Shared	8.65	4.93305	1	1	2	2
2x60	7x42	Shared	6.36	4.21667	1	1	2	1
3x32	3x36	5ht1_off	4.67	0	1	1	1	1
3x32	7x42	Shared	11.49	9.67306	1	1	1	1
3x32	Lig	Shared	11.78	13.5931	1	1	1	0
3x33	Lig	Shared	4.77	10.6494	0	0	1	0
3x36	6x48	Shared	3.92	5.36694	1	1	1	1
3x36	Lig	Shared	5.3	9.07722	1	1	1	0
3x37	4x53	Shared	6.4	4.72611	0	0	1	2
3x37	5x461	5ht1_off	5.03	0	0	0	1	1
3x37	Lig	Shared	4.92	3.24528	0	0	1	0
3x40	5x47	5ht1_off	3.77	0	0	1	1	2
3x40	5x50	Shared	5.08	3.34278	0	1	1	2
3x40	6x44	Shared	11.3	4.53472	0	1	1	2
3x40	Lig	5ht1_off	4.77	0	0	1	1	0
E2x52	Lig	Shared	3.98	7.98361	0	0	1	0
5x44	5x48	Shared	6.24	3.81722	0	1	1	2
5x44	Lig	5ht1_off	3.94	0	0	1	1	0
5x47	5x48	Shared	11.35	5.07083	1	1	2	2
5x47	6x52	Shared	33.22	19.4972	1	1	2	1
5x48	6x52	5ht1_off	6.19	0	1	1	2	1
5x48	6x56	Shared	4.69	4.78639	1	1	2	2
6x44	7x45	5ht1_off	8.46	0	0	1	2	2
6x48	6x51	Shared	9.02	4.59306	1	1	1	1
6x48	6x52	Shared	6.01	7.34861	1	1	1	1
6x48	7x41	Shared	12.67	8.20611	1	1	1	2
6x48	7x42	5ht1_off	3.86	0	1	1	1	1
6x48	7x45	Shared	3.39	10.4211	1	1	1	2
6x48	Lig	Shared	17.49	3.9975	1	1	1	0
6x51	6x52	Shared	10.72	3.63417	1	1	1	1
6x51	7x34	5ht1_off	3.22	0	1	1	1	2
6x51	7x38	Shared	7.78	4.21833	1	1	1	2
6x51	Lig	Shared	15.45	13.7783	1	1	1	0
6x52	Lig	Shared	13.83	8.96861	1	1	1	0
6x54	7x34	Shared	5.02	3.1025	0	1	2	2
7x38	7x42	5ht1_off	6.24	0	0	0	2	1
7x39	7x42	Shared	6.75	8.94917	1	1	2	1
7x42	Lig	Shared	4.7	6.3175	1	1	1	0
5x43	Lig	Shared	3.01	5.05083	0	0	1	0
6x55	6x56	5ht1_off	3	0	0	1	1	2
5x40	Lig	5ht1_off	0.98	0	0	0	1	0
2x57	7x42	5ht1_on	0	3.89083	0	1	2	1
3x33	4x57	5ht1_on	0	6.10028	0	0	1	2
3x37	4x56	5ht1_on	0	5.95333	0	0	1	2
3x40	6x48	5ht1_on	0	7.17695	0	1	1	1
5x39	5x43	5ht1_on	0	6.18222	0	0	2	1
5x40	6x59	5ht1_on	0	4.82556	0	0	1	2
5x44	6x56	5ht1_on	0	6.34667	0	1	1	2
5x47	6x44	5ht1_on	0	7.65139	1	1	2	2
6x44	6x48	5ht1_on	0	5.54222	0	1	2	1
6x51	6x55	5ht1_on	0	4.2125	1	1	1	1
6x55	Lig	5ht1_on	0	7.34028	0	1	1	0
6x51	6x54	5ht1_on	0	3.20417	1	1	1	2
3x29	E2x52	5ht1_on	0	3.1675	0	0	2	1
5x461	Lig	5ht1_on	0	3.08222	0	0	1	0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	5ht1_off	5ht1b_off
	5ht1_on	5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on

Network Difference
Value	5ht1_off	5ht1_on
I_min	3.17	3.22917
Number of Linked Nodes	241	279
Number of Specific Nodes	0 (0.00%)	38 (13.62%)
Number of Shared Nodes	241 (100.00%)	241 (86.38%)
Number of Links	282	316
Number of Specific Links	125 (44.33%)	159 (50.32%)
Number of Shared Links	157 (55.67%)	157 (49.68%)
Number of Hubs	38	34
Number of Specific Hubs	16 (42.11%)	12 (35.29%)
Number of Shared Hubs	22 (57.89%)	22 (64.71%)
Average % Shared Neighbours (Jaccard)	35.50
Average % Shared Neighbours (Otsuka)	44.48
Average % Shared Neighbours (Overlap Coefficient)	53.11
Average % Shared Cliques (k3-6)	83.33
Graphlets Similarity	0.620301

Paths Difference
Value	5ht1_off	5ht1_on
Number Of Nodes in MetaPath	69	72
Specific Nodes in MetaPath	31 (44.93%)	34 (47.22%)
Shared Nodes in MetaPath	241 (100.00%)	241 (100.00%)
Number Of Links MetaPath	70	75
Specific Links in MetaPath	50 (71.43%)	55 (73.33%)
Shared Links in MetaPath	157 (55.67%)	157 (55.67%)
Number of Shortest Paths	46833	67270
Length Of Smallest Path	3	3
Average Path Length	13.348	14.0249
Length of Longest Path	37	29
Minimum Path Strength	1.435	0.422222
Average Path Strength	6.43147	5.55746
Maximum Path Strength	23.525	14.3693
Minimum Path Correlation	0.7	0.7
Average Path Correlation	0.927091	0.917672
Maximum Path Correlation	0.99	0.99
Minimum % Of Corr. Nodes	3.44828	3.84615
Average % Of Corr. Nodes	50.1046	40.7084
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	44.7762	41.9655
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 5ht1_off_on.zip<

You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.

You can also read or download a guide explaining the meaning of all files and numerical data.