psnGPCR

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Orange: nodes, hubs and links specific of 5ht1b_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of 5ht1b_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	5ht1b_off Int. Strength	5ht1b_on Int. Strength	5ht1b_off Hub1?	5ht1b_on Hub1?	5ht1b_off Hub2?	5ht1b_on Hub2?	ConSurf1	ConSurf2
1	NT.I39	NT.Q41	5ht1b_off	6.86	0	No	No	Yes	No	2	2
2	NT.Q41	NT.Y40	5ht1b_off	24.8	0	Yes	No	No	No	2	3
3	7x32	NT.Y40	5ht1b_off	5.34	0	No	No	No	No	2	3
4	7x35	NT.Y40	5ht1b_off	5.75	0	No	No	No	No	4	3
5	2x67	NT.Q41	5ht1b_off	8.22	0	No	No	Yes	No	4	2
6	1x32	NT.I44	5ht1b_off	8.72	0	Yes	No	No	No	3	1
7	1x31	1x34	5ht1b_off	3.42	0	No	No	No	No	2	5
8	1x36	2x61	5ht1b_off	3.17	0	No	No	No	No	6	7
9	1x39	2x61	5ht1b_off	5.9	0	No	No	No	No	6	7
10	1x45	7x47	5ht1b_off	4.73	0	No	No	No	No	5	6
11	1x46	2x57	5ht1b_off	9.03	0	No	No	Yes	Yes	7	7
12	1x52	1x56	5ht1b_off	7.78	0	Yes	No	No	No	7	8
13	1x53	2x47	5ht1b_off	3.39	0	No	No	No	No	9	9
14	1x54	2x47	5ht1b_off	3.25	0	No	No	No	No	7	9
15	1x56	8x53	5ht1b_off	3.36	0	No	No	No	No	8	8
16	2x37	2x39	5ht1b_off	3.36	0	No	No	No	No	8	8
17	2x38	2x41	5ht1b_off	4.17	0	No	Yes	No	No	6	5
18	2x39	3x50	5ht1b_off	4.15	0	No	No	No	No	8	9
19	2x49	3x38	5ht1b_off	3.36	0	No	No	No	No	8	8
20	2x52	3x35	5ht1b_off	4.76	0	No	No	No	No	7	6
21	2x52	4x50	5ht1b_off	3.42	0	No	No	Yes	No	7	9
22	2x53	2x56	5ht1b_off	4.81	0	No	No	Yes	No	8	7
23	2x62	E1x52	5ht1b_off	4.24	0	No	No	No	No	5	6
24	3x24	E1x50	5ht1b_off	3.68	0	No	No	Yes	Yes	4	8
25	3x28	E1x50	5ht1b_off	10.31	0	Yes	Yes	Yes	Yes	6	8
26	3x26	4x61	5ht1b_off	13.14	0	No	No	No	No	6	7
27	3x32	3x36	5ht1b_off	4.67	0	Yes	No	No	No	8	6
28	3x38	4x53	5ht1b_off	3.42	0	No	No	No	No	8	8
29	3x40	5x47	5ht1b_off	3.77	0	Yes	No	Yes	Yes	8	8
30	3x40	5x50	5ht1b_off	5.08	0	Yes	No	No	No	8	9
31	3x40	Lig	5ht1b_off	4.77	0	Yes	No	Yes	Yes	8	0
32	3x41	5x49	5ht1b_off	4.01	0	Yes	Yes	No	No	6	5
33	3x42	4x50	5ht1b_off	5.29	0	Yes	Yes	Yes	No	7	9
34	3x44	5x54	5ht1b_off	4.76	0	No	No	No	No	7	8
35	3x49	3x50	5ht1b_off	7.15	0	Yes	Yes	No	No	9	9
36	3x51	3x52	5ht1b_off	4.82	0	Yes	Yes	Yes	No	8	5
37	3x52	3x56	5ht1b_off	4.47	0	Yes	No	No	No	5	6
38	3x54	5x68	5ht1b_off	5.01	0	No	No	No	No	9	7
39	3x55	5x60	5ht1b_off	6.47	0	No	No	No	No	7	6
40	I2x52	I2x56	5ht1b_off	4.05	0	No	No	No	No	5	5
41	4x38	4x40	5ht1b_off	4.5	0	No	No	No	No	8	5
42	4x54	4x58	5ht1b_off	4.28	0	No	No	No	No	4	5
43	4x63	E2.D204	5ht1b_off	3.35	0	No	No	No	No	6	4
44	4x63	5x36	5ht1b_off	14.81	0	No	No	No	No	6	6
45	E2.K191	E2.R188	5ht1b_off	4.95	0	No	No	No	No	3	5
46	5x44	Lig	5ht1b_off	3.94	0	No	No	Yes	Yes	6	0
47	5x45	5x46	5ht1b_off	3.68	0	No	No	No	No	3	4
48	5x48	6x52	5ht1b_off	6.19	0	Yes	Yes	Yes	Yes	6	7
49	5x58	5x62	5ht1b_off	6.95	0	Yes	No	Yes	Yes	9	6
50	5x58	6x38	5ht1b_off	5.79	0	Yes	No	No	No	9	6
51	5x58	6x41	5ht1b_off	3.52	0	Yes	No	Yes	No	9	8
52	5x62	6x31	5ht1b_off	5.14	0	Yes	Yes	Yes	No	6	6
53	5x64	5x67	5ht1b_off	4.31	0	Yes	No	No	No	6	5
54	5x64	5x68	5ht1b_off	8.14	0	Yes	No	No	No	6	7
55	5x66	5x69	5ht1b_off	6.26	0	No	No	No	No	6	5
56	5x66	6x31	5ht1b_off	13.86	0	No	No	Yes	No	6	6
57	6x26	6x29	5ht1b_off	21.09	0	No	No	No	No	4	7
58	6x31	6x32	5ht1b_off	3.71	0	Yes	No	No	No	6	8
59	6x40	7x52	5ht1b_off	5.89	0	No	No	Yes	Yes	8	8
60	6x44	7x45	5ht1b_off	8.46	0	Yes	Yes	Yes	No	9	9
61	6x48	7x42	5ht1b_off	3.86	0	Yes	Yes	Yes	Yes	7	7
62	6x49	6x53	5ht1b_off	7.14	0	Yes	No	No	No	6	6
63	6x54	7x30	5ht1b_off	3.98	0	No	No	No	No	4	4
64	6x54	7x34	5ht1b_off	5.02	0	No	No	No	Yes	4	4
65	6x58	7x30	5ht1b_off	3.94	0	Yes	No	No	No	4	4
66	6x58	7x34	5ht1b_off	12.44	0	Yes	No	No	Yes	4	4
67	6x61	7x30	5ht1b_off	7.37	0	No	No	No	No	6	4
68	7x33	7x36	5ht1b_off	7.54	0	No	No	No	No	4	5
69	7x37	7x40	5ht1b_off	3.65	0	Yes	Yes	No	No	6	7
70	7x42	Lig	5ht1b_off	4.7	0	Yes	Yes	Yes	Yes	7	0
71	7x43	7x48	5ht1b_off	5.71	0	No	No	Yes	No	4	6
72	7x48	7x51	5ht1b_off	4.42	0	Yes	No	No	No	6	7
73	7x53	8x50	5ht1b_off	4.13	0	No	Yes	Yes	Yes	9	8
74	8x47	8x50	5ht1b_off	7.25	0	No	No	Yes	Yes	9	8
75	8x48	8x51	5ht1b_off	9.45	0	No	No	No	No	6	9
76	8x48	8x52	5ht1b_off	3.82	0	No	No	No	No	6	4
77	8x55	CT.F386	5ht1b_off	16.97	0	No	No	No	No	5	4
78	2x42	4x42	5ht1b_off	3.15	0	No	No	No	No	7	7
79	4x41	I2x53	5ht1b_off	3.09	0	No	No	Yes	Yes	6	8
80	5x61	6x34	5ht1b_off	3.04	0	No	No	No	No	9	8
81	2x62	E1x51	5ht1b_off	3.01	0	No	No	No	No	5	4
82	5x43	Lig	5ht1b_off	3.01	0	No	No	Yes	Yes	7	0
83	6x55	6x56	5ht1b_off	3	0	No	No	No	No	6	6
84	1x57	2x40	5ht1b_off	2.96	0	No	No	No	No	8	9
85	5x58	5x59	5ht1b_off	2.9	0	Yes	No	No	No	9	3
86	4x60	4x61	5ht1b_off	2.89	0	No	No	No	No	7	7
87	3x43	6x40	5ht1b_off	2.85	0	No	Yes	No	No	8	8
88	7x47	7x51	5ht1b_off	2.85	0	No	No	No	No	6	7
89	2x40	2x43	5ht1b_off	2.83	0	No	No	No	No	9	8
90	1x55	1x59	5ht1b_off	2.77	0	No	No	No	No	4	6
91	3x50	3x53	5ht1b_off	2.77	0	No	No	No	No	9	7
92	5x65	6x31	5ht1b_off	2.77	0	No	No	Yes	No	8	6
93	1x32	NT.Q41	5ht1b_off	2.71	0	Yes	No	Yes	No	3	2
94	1x52	7x54	5ht1b_off	2.59	0	Yes	No	No	No	7	7
95	7x54	8x54	5ht1b_off	2.59	0	No	No	No	No	7	7
96	5x36	5x38	5ht1b_off	2.57	0	No	No	No	No	6	3
97	5x60	5x61	5ht1b_off	2.51	0	No	No	No	No	6	9
98	8x58	CT.F386	5ht1b_off	2.51	0	No	No	No	No	6	4
99	1x52	8x57	5ht1b_off	2.44	0	Yes	No	No	No	7	6
100	4x63	E2.R188	5ht1b_off	2	0	No	No	No	No	6	5
101	6x57	6x61	5ht1b_off	1.71	0	No	No	No	No	5	6
102	5x69	6x27	5ht1b_off	1.62	0	No	No	No	No	5	5
103	6x28	6x32	5ht1b_off	1.61	0	No	No	No	No	5	8
104	NT.I44	NT.S43	5ht1b_off	1.55	0	No	No	No	No	1	1
105	7x52	7x56	5ht1b_off	1.55	0	Yes	Yes	No	No	8	7
106	4x40	4x44	5ht1b_off	1.52	0	No	No	No	No	5	3
107	1x48	1x49	5ht1b_off	1.5	0	No	No	No	No	4	8
108	2x67	E1x49	5ht1b_off	1.5	0	No	No	No	No	4	3
109	4x55	4x58	5ht1b_off	1.5	0	No	No	No	No	4	5
110	1x35	2x65	5ht1b_off	1.49	0	No	No	No	No	4	6
111	E2.E198	E2.S197	5ht1b_off	1.44	0	No	No	No	No	4	2
112	5x37	5x38	5ht1b_off	1.43	0	No	No	No	No	3	3
113	5x52	5x55	5ht1b_off	1.43	0	No	No	No	No	3	5
114	6x37	6x40	5ht1b_off	1.43	0	No	No	No	No	8	8
115	1x34	1x37	5ht1b_off	1.41	0	No	No	No	No	5	4
116	6x30	6x34	5ht1b_off	1.41	0	No	No	No	No	8	8
117	6x58	7x31	5ht1b_off	1.41	0	Yes	No	No	No	4	2
118	1x35	1x38	5ht1b_off	1.38	0	No	No	No	No	4	5
119	1x30	1x31	5ht1b_off	1.35	0	No	No	No	No	3	2
120	5x62	5x63	5ht1b_off	1.26	0	Yes	Yes	No	No	6	4
121	3x26	3x27	5ht1b_off	1.19	0	No	No	No	No	6	5
122	5x58	6x35	5ht1b_off	1.19	0	Yes	No	No	No	9	8
123	NT.D42	NT.Y38	5ht1b_off	1.15	0	No	No	No	No	2	3
124	1x58	1x59	5ht1b_off	1.03	0	No	No	No	No	3	6
125	1x29	1x30	Shared	3.28	1.64	No	No	No	No	3	3
126	1x32	2x65	Shared	4.55	4.55	Yes	No	No	No	3	6
127	1x36	2x65	Shared	4.81	4.81	No	No	No	No	6	6
128	1x39	7x39	Shared	26.19	22.78	No	No	Yes	Yes	6	6
129	1x43	2x57	Shared	10.54	7.53	No	No	Yes	Yes	6	7
130	1x43	2x58	Shared	3.5	1.75	No	No	No	No	6	9
131	1x46	2x54	Shared	6.4	4.8	No	No	No	No	7	7
132	1x46	7x47	Shared	4.42	7.37	No	No	No	No	7	6
133	1x47	2x54	Shared	7.99	7.99	No	No	No	No	6	7
134	1x49	7x50	Shared	5.34	1.78	No	No	No	No	8	9
135	1x50	2x47	Shared	4.69	4.69	No	Yes	No	No	9	9
136	1x50	2x50	Shared	6.73	6.73	No	Yes	Yes	Yes	9	9
137	1x50	7x50	Shared	13.03	6.52	No	Yes	No	No	9	9
138	1x52	8x54	Shared	5.36	6.43	Yes	No	No	No	7	7
139	1x54	2x48	Shared	4.61	6.14	No	No	No	No	7	6
140	1x56	8x50	Shared	6.49	10.38	No	No	Yes	Yes	8	8
141	1x60	I1x50	Shared	10.32	8.84	No	No	No	Yes	7	8
142	I1x48	I1x51	Shared	5.64	1.13	No	No	No	No	6	8
143	8x49	I1x50	Shared	4.07	5.43	No	No	No	Yes	6	8
144	2x41	I1x51	Shared	4.36	6.53	No	No	No	No	5	8
145	2x37	2x40	Shared	7.31	7.31	No	No	No	No	8	9
146	2x38	I2x57	Shared	4.32	7.21	No	Yes	No	Yes	6	7
147	2x38	4x39	Shared	9.74	1.95	No	Yes	No	No	6	3
148	2x41	4x39	Shared	4.17	2.78	No	No	No	No	5	3
149	2x42	3x46	Shared	4.28	4.28	No	No	No	Yes	7	9
150	2x42	3x49	Shared	4.07	5.43	No	No	Yes	Yes	7	9
151	2x43	7x53	Shared	19.34	3.63	No	No	No	Yes	8	9
152	2x45	3x42	Shared	12.55	6.97	No	No	Yes	Yes	9	7
153	2x45	4x46	Shared	9.29	9.29	No	No	No	No	9	7
154	2x46	2x50	Shared	4.07	4.07	No	Yes	Yes	Yes	9	9
155	2x46	3x43	Shared	4.15	5.54	No	Yes	No	Yes	9	8
156	2x49	3x42	Shared	5.48	9.58	No	No	Yes	Yes	8	7
157	2x49	4x50	Shared	10.92	4.85	No	No	Yes	No	8	9
158	2x50	7x46	Shared	8.83	7.36	Yes	Yes	No	No	9	9
159	2x50	7x49	Shared	6.73	8.08	Yes	Yes	No	Yes	9	9
160	2x51	2x54	Shared	4.5	4.5	No	Yes	No	No	8	7
161	2x52	2x551	Shared	4.15	2.77	No	No	No	No	7	5
162	2x53	2x57	Shared	4.56	4.56	No	No	Yes	Yes	8	7
163	2x53	7x46	Shared	8.08	8.08	No	No	No	No	8	9
164	2x551	3x31	Shared	4.5	3	No	No	No	No	5	5
165	2x56	3x28	Shared	4.9	4.9	Yes	No	Yes	Yes	7	6
166	2x56	3x32	Shared	13.15	8.76	Yes	No	Yes	No	7	8
167	2x56	7x42	Shared	5.05	5.05	Yes	No	Yes	Yes	7	7
168	2x57	7x39	Shared	5.82	5.82	Yes	Yes	Yes	Yes	7	6
169	2x59	3x28	Shared	14.09	18.79	No	No	Yes	Yes	6	6
170	2x60	3x28	Shared	4.94	4.94	No	No	Yes	Yes	6	6
171	2x60	7x39	Shared	8.65	9.88	No	No	Yes	Yes	6	6
172	2x60	7x42	Shared	6.36	6.36	No	No	Yes	Yes	6	7
173	2x61	7x39	Shared	4.85	3.64	No	No	Yes	Yes	7	6
174	2x63	E1x50	Shared	8.68	2.89	No	No	Yes	Yes	6	8
175	2x63	E2.E198	Shared	5.61	4.49	No	No	No	No	6	4
176	2x64	7x39	Shared	9.7	4.85	No	No	Yes	Yes	5	6
177	2x66	2x67	Shared	3.64	3.64	No	Yes	No	No	5	4
178	E1x50	E1x52	Shared	12.53	3.42	Yes	Yes	No	No	8	6
179	3x25	E1x50	Shared	5.22	5.22	No	No	Yes	Yes	9	8
180	E1x50	E2x50	Shared	15.67	19.59	Yes	Yes	No	No	8	9
181	3x24	E1x52	Shared	7.45	13.41	No	No	No	No	4	6
182	3x25	E2x50	Shared	7.28	7.28	No	No	No	No	9	9
183	3x28	3x29	Shared	4.56	5.69	Yes	Yes	No	No	6	6
184	3x29	E2x50	Shared	3.17	4.76	No	No	No	No	6	9
185	3x30	4x57	Shared	6.52	3.26	No	No	No	No	7	7
186	3x32	7x42	Shared	11.49	9.2	Yes	No	Yes	Yes	8	7
187	3x32	Lig	Shared	11.78	8.29	Yes	No	Yes	Yes	8	0
188	3x33	Lig	Shared	4.77	16.46	No	No	Yes	Yes	6	0
189	3x34	4x53	Shared	3.2	3.2	No	Yes	No	No	6	8
190	3x34	4x57	Shared	4.8	3.2	No	Yes	No	No	6	7
191	3x36	6x48	Shared	3.92	6.53	No	No	Yes	Yes	6	7
192	3x36	Lig	Shared	5.3	5.38	No	No	Yes	Yes	6	0
193	3x37	4x53	Shared	6.4	6.4	No	No	No	No	7	8
194	3x37	5x461	Shared	5.03	5.03	No	No	No	No	7	7
195	3x37	Lig	Shared	4.92	5	No	No	Yes	Yes	7	0
196	3x38	4x50	Shared	5.19	3.89	No	No	Yes	No	8	9
197	3x40	6x44	Shared	11.3	6.28	Yes	No	Yes	Yes	8	9
198	3x41	3x44	Shared	5.22	6.53	Yes	Yes	No	No	6	7
199	3x41	4x49	Shared	3.68	3.68	Yes	Yes	No	No	6	7
200	3x41	4x52	Shared	14.03	11.02	Yes	Yes	No	No	6	5
201	3x41	5x50	Shared	13.51	12.16	Yes	Yes	No	No	6	9
202	3x42	4x46	Shared	7.95	9.28	Yes	Yes	No	No	7	7
203	3x42	4x49	Shared	13.84	5.54	Yes	Yes	No	No	7	7
204	3x43	6x44	Shared	3.65	4.87	No	Yes	Yes	Yes	8	9
205	3x44	5x53	Shared	3.17	4.76	No	No	No	No	7	7
206	3x45	4x45	Shared	9.13	7.61	No	No	No	No	6	6
207	3x45	4x49	Shared	3.21	1.6	No	No	No	No	6	7
208	3x48	3x52	Shared	17.08	17.08	No	No	Yes	No	6	5
209	3x49	I2x53	Shared	9.2	6.9	Yes	Yes	Yes	Yes	9	8
210	3x49	I2x57	Shared	10.72	4.76	Yes	Yes	No	Yes	9	7
211	3x51	3x55	Shared	3.75	8.74	Yes	Yes	No	No	8	7
212	3x51	5x57	Shared	3.52	5.86	Yes	Yes	No	No	8	6
213	3x51	5x60	Shared	12.35	14.4	Yes	Yes	No	No	8	6
214	3x52	I2x53	Shared	18.33	17.36	Yes	No	Yes	Yes	5	8
215	3x54	5x64	Shared	4.1	2.73	No	No	Yes	No	9	6
216	3x55	5x64	Shared	5.64	7.06	No	No	Yes	No	7	6
217	3x56	I2x52	Shared	6.5	6.5	No	No	No	No	6	5
218	I2x53	I2x56	Shared	8.36	3.58	Yes	Yes	No	No	8	5
219	I2x53	I2x57	Shared	17.49	12.35	Yes	Yes	No	Yes	8	7
220	4x38	4x39	Shared	5.25	3.5	No	No	No	No	8	3
221	4x52	4x56	Shared	6.28	6.28	No	No	No	No	5	7
222	4x59	4x60	Shared	5.84	5.84	No	No	No	No	7	7
223	4x59	5x39	Shared	5.56	2.78	No	No	No	No	7	8
224	E2.E198	E2x51	Shared	4.28	15.69	No	No	No	No	4	3
225	E2x52	Lig	Shared	3.98	7.07	No	No	Yes	Yes	6	0
226	E2.D204	E2.N202	Shared	9.42	1.35	No	No	No	No	4	6
227	5x44	5x48	Shared	6.24	3.75	No	No	Yes	Yes	6	6
228	5x45	5x48	Shared	6.31	3.79	No	No	Yes	Yes	3	6
229	5x47	5x48	Shared	11.35	12.38	Yes	Yes	Yes	Yes	8	6
230	5x47	5x51	Shared	7.78	7.78	Yes	Yes	No	No	8	6
231	5x47	6x49	Shared	3.65	3.65	Yes	Yes	Yes	No	8	6
232	5x47	6x52	Shared	33.22	25.72	Yes	Yes	Yes	Yes	8	7
233	5x48	6x56	Shared	4.69	4.69	Yes	Yes	No	No	6	6
234	5x49	5x50	Shared	5.78	4.33	No	No	No	No	5	9
235	5x51	6x44	Shared	5.19	3.89	No	No	Yes	Yes	6	9
236	5x53	5x57	Shared	5.54	8.3	No	No	No	No	7	6
237	5x54	6x41	Shared	4.15	4.15	No	No	Yes	No	8	8
238	5x55	6x41	Shared	5.71	4.28	No	No	Yes	No	5	8
239	5x62	5x66	Shared	4.12	9.26	Yes	Yes	No	No	6	6
240	6x36	7x56	Shared	7.99	1.6	No	No	No	No	8	7
241	6x44	6x45	Shared	3.77	3.77	Yes	Yes	No	No	9	6
242	6x45	6x49	Shared	4.28	4.28	No	No	Yes	No	6	6
243	6x47	7x45	Shared	9.45	9.45	No	No	Yes	No	7	9
244	6x48	6x51	Shared	9.02	6.01	Yes	Yes	Yes	Yes	7	8
245	6x48	6x52	Shared	6.01	11.02	Yes	Yes	Yes	Yes	7	7
246	6x48	7x41	Shared	12.67	8.44	Yes	Yes	No	No	7	7
247	6x48	7x45	Shared	3.39	4.52	Yes	Yes	Yes	No	7	9
248	6x48	Lig	Shared	17.49	3.86	Yes	Yes	Yes	Yes	7	0
249	6x49	6x50	Shared	3.28	3.28	Yes	No	No	No	6	9
250	6x50	7x37	Shared	10.11	11.56	No	No	Yes	Yes	9	6
251	6x51	6x52	Shared	10.72	6.43	Yes	Yes	Yes	Yes	8	7
252	6x51	7x34	Shared	3.22	7.5	Yes	Yes	No	Yes	8	4
253	6x51	7x38	Shared	7.78	3.89	Yes	Yes	No	No	8	6
254	6x51	Lig	Shared	15.45	10.74	Yes	Yes	Yes	Yes	8	0
255	6x52	Lig	Shared	13.83	11.57	Yes	Yes	Yes	Yes	7	0
256	6x54	7x37	Shared	3.77	5.02	No	No	Yes	Yes	4	6
257	6x58	6x59	Shared	3.35	1.68	Yes	No	No	No	4	5
258	7x36	7x37	Shared	7.5	4.29	No	No	Yes	Yes	5	6
259	7x38	7x42	Shared	6.24	3.75	No	No	Yes	Yes	6	7
260	7x39	7x42	Shared	6.75	8.68	Yes	Yes	Yes	Yes	6	7
261	7x45	7x49	Shared	13.62	13.62	Yes	No	No	Yes	9	9
262	8x47	8x49	Shared	10.77	16.16	No	No	No	No	9	6
263	8x51	8x55	Shared	3.93	1.31	No	No	No	No	9	5
264	3x47	5x57	Shared	3.15	3.15	No	No	No	No	9	6
265	3x34	4x54	Shared	3.04	3.04	No	Yes	No	No	6	4
266	1x60	I1x49	Shared	3	7.51	No	No	No	No	7	6
267	4x44	4x48	Shared	2.98	1.49	No	No	No	No	3	2
268	2x50	3x39	Shared	2.94	7.36	Yes	Yes	No	No	9	9
269	7x48	7x52	Shared	2.94	2.94	Yes	No	Yes	Yes	6	8
270	2x51	2x55	Shared	2.85	7.14	No	Yes	No	No	8	5
271	2x55	2x551	Shared	2.85	2.85	No	No	No	No	5	5
272	3x21	E1x50	Shared	2.81	1.41	No	No	Yes	Yes	6	8
273	3x30	4x61	Shared	2.64	1.32	No	No	No	No	7	7
274	3x23	3x27	Shared	2.62	3.93	No	No	No	No	1	5
275	7x54	8x50	Shared	2.59	15.56	No	No	Yes	Yes	7	8
276	4x56	5x42	Shared	2.42	1.21	No	No	No	No	7	4
277	1x42	7x39	Shared	2.35	2.35	No	No	Yes	Yes	6	6
278	5x38	5x39	Shared	2.34	2.34	No	No	No	No	3	8
279	1x28	1x30	Shared	1.78	5.34	No	No	No	No	6	3
280	6x41	6x42	Shared	1.71	1.71	Yes	No	No	No	8	6
281	1x57	2x44	Shared	1.7	5.09	No	No	No	No	8	6
282	6x43	7x48	Shared	1.62	1.62	No	No	Yes	No	6	6
283	6x43	7x52	Shared	1.62	1.62	No	No	Yes	Yes	6	8
284	5x41	5x45	Shared	1.6	1.6	No	No	No	No	5	3
285	6x30	6x33	Shared	1.51	1.51	No	No	No	No	8	8
286	1x29	1x33	Shared	1.49	1.49	No	No	No	No	3	5
287	6x39	7x52	Shared	1.47	5.89	No	No	Yes	Yes	7	8
288	1x29	1x32	Shared	1.41	2.82	No	No	Yes	No	3	3
289	8x54	8x58	Shared	1.26	6.28	No	No	No	No	7	6
290	5x40	Lig	Shared	0.98	3	No	No	Yes	Yes	6	0
291	1x28	1x31	5ht1b_on	0	9.88	No	No	No	No	6	2
292	1x35	1x39	5ht1b_on	0	4.15	No	No	No	No	4	6
293	1x39	2x64	5ht1b_on	0	4.42	No	No	No	No	6	5
294	1x43	7x39	5ht1b_on	0	3.64	No	No	Yes	Yes	6	6
295	1x44	1x48	5ht1b_on	0	8.3	No	No	No	No	5	4
296	1x50	2x51	5ht1b_on	0	4.12	No	Yes	No	Yes	9	8
297	1x53	8x50	5ht1b_on	0	9.18	No	No	Yes	Yes	9	8
298	1x54	2x51	5ht1b_on	0	4.28	No	No	No	Yes	7	8
299	I1x49	I1x50	5ht1b_on	0	7.05	No	No	No	Yes	6	8
300	2x40	I1x50	5ht1b_on	0	6.87	No	No	No	Yes	9	8
301	8x50	I1x50	5ht1b_on	0	3.65	Yes	Yes	No	Yes	8	8
302	2x40	8x47	5ht1b_on	0	5.45	No	No	No	No	9	9
303	2x46	3x42	5ht1b_on	0	5.14	No	Yes	Yes	Yes	9	7
304	2x46	3x46	5ht1b_on	0	4.28	No	Yes	No	Yes	9	9
305	2x46	7x49	5ht1b_on	0	4.12	No	Yes	No	Yes	9	9
306	2x53	7x42	5ht1b_on	0	3.79	No	No	Yes	Yes	8	7
307	2x57	7x42	5ht1b_on	0	13.17	Yes	Yes	Yes	Yes	7	7
308	2x64	7x35	5ht1b_on	0	4.34	No	No	No	No	5	4
309	2x66	E1x49	5ht1b_on	0	5.17	No	Yes	No	No	5	3
310	E1x49	E1x51	5ht1b_on	0	7.76	No	No	No	No	3	4
311	3x26	4x63	5ht1b_on	0	26.8	No	No	No	No	6	6
312	3x40	6x48	5ht1b_on	0	10.57	Yes	No	Yes	Yes	8	7
313	3x43	7x49	5ht1b_on	0	10.98	No	Yes	No	Yes	8	9
314	3x43	7x53	5ht1b_on	0	8.21	No	Yes	No	Yes	8	9
315	3x46	3x50	5ht1b_on	0	7.52	No	Yes	No	No	9	9
316	3x46	7x53	5ht1b_on	0	6.04	No	Yes	No	Yes	9	9
317	3x50	5x58	5ht1b_on	0	5.14	No	No	Yes	No	9	9
318	3x50	7x53	5ht1b_on	0	8.23	No	No	No	Yes	9	9
319	3x51	5x61	5ht1b_on	0	4.84	Yes	Yes	No	No	8	9
320	3x55	3x56	5ht1b_on	0	7.23	No	No	No	No	7	6
321	4x62	E2.D204	5ht1b_on	0	11.94	No	No	No	No	6	4
322	4x62	5x36	5ht1b_on	0	10.18	No	No	No	No	6	6
323	5x36	E2.D204	5ht1b_on	0	7.56	No	No	No	No	6	4
324	5x36	5x39	5ht1b_on	0	26.13	No	No	No	No	6	8
325	5x44	6x52	5ht1b_on	0	6.49	No	No	Yes	Yes	6	7
326	5x44	6x55	5ht1b_on	0	7.99	No	No	No	No	6	6
327	5x54	6x44	5ht1b_on	0	4.87	No	No	Yes	Yes	8	9
328	5x58	6x37	5ht1b_on	0	7.03	Yes	No	No	No	9	8
329	5x58	6x40	5ht1b_on	0	13.3	Yes	No	No	No	9	8
330	5x62	6x30	5ht1b_on	0	6.73	Yes	Yes	No	No	6	8
331	5x62	6x34	5ht1b_on	0	6.24	Yes	Yes	No	No	6	8
332	5x62	6x37	5ht1b_on	0	12.89	Yes	Yes	No	No	6	8
333	5x66	6x30	5ht1b_on	0	11.63	No	No	No	No	6	8
334	6x32	6x36	5ht1b_on	0	4.5	No	No	No	No	8	8
335	6x55	Lig	5ht1b_on	0	6.11	No	No	Yes	Yes	6	0
336	6x57	E3.W345	5ht1b_on	0	6.13	No	No	No	No	5	0
337	6x58	Lig	5ht1b_on	0	9.59	Yes	No	Yes	Yes	4	0
338	E3.F346	E3.W345	5ht1b_on	0	7.02	No	No	No	No	4	0
339	7x31	7x35	5ht1b_on	0	4.07	No	No	No	No	2	4
340	7x33	7x37	5ht1b_on	0	5.02	No	No	Yes	Yes	4	6
341	7x34	7x35	5ht1b_on	0	5.97	No	Yes	No	No	4	4
342	7x34	7x38	5ht1b_on	0	3.89	No	Yes	No	No	4	6
343	7x34	Lig	5ht1b_on	0	12.39	No	Yes	Yes	Yes	4	0
344	7x43	7x47	5ht1b_on	0	4.15	No	No	No	No	4	6
345	7x52	7x53	5ht1b_on	0	4.84	Yes	Yes	No	Yes	8	9
346	7x55	8x51	5ht1b_on	0	10.08	No	No	No	No	5	9
347	8x50	8x54	5ht1b_on	0	8.57	Yes	Yes	No	No	8	7
348	8x52	8x56	5ht1b_on	0	4.07	No	No	No	No	4	5
349	5x48	6x53	5ht1b_on	0	3.63	Yes	Yes	No	No	6	6
350	2x37	2x38	5ht1b_on	0	3.5	No	No	No	Yes	8	6
351	3x34	3x35	5ht1b_on	0	3.38	No	Yes	No	No	6	6
352	1x60	8x53	5ht1b_on	0	3.36	No	No	No	No	7	8
353	4x58	4x59	5ht1b_on	0	3.28	No	No	No	No	5	7
354	6x50	7x40	5ht1b_on	0	3.28	No	No	No	No	9	7
355	4x56	5x43	5ht1b_on	0	3.1	No	No	No	No	7	7
356	6x57	6x58	5ht1b_on	0	3.04	No	No	Yes	No	5	4
357	4x61	4x63	5ht1b_on	0	3.01	No	No	No	No	7	6
358	1x38	1x42	5ht1b_on	0	2.85	No	No	No	No	5	6
359	5x69	5x70	5ht1b_on	0	2.85	No	No	No	No	5	0
360	8x57	8x58	5ht1b_on	0	2.85	No	No	No	No	6	6
361	1x57	2x41	5ht1b_on	0	2.52	No	No	No	No	8	5
362	6x31	6x35	5ht1b_on	0	2.48	Yes	No	No	No	6	8
363	3x52	4x41	5ht1b_on	0	2	Yes	No	No	No	5	6
364	E2.T203	Lig	5ht1b_on	0	2	No	No	Yes	Yes	7	0
365	2x38	4x42	5ht1b_on	0	1.87	No	Yes	No	No	6	7
366	3x21	3x22	5ht1b_on	0	1.64	No	No	No	No	6	4
367	5x69	6x33	5ht1b_on	0	1.62	No	No	No	No	5	8
368	2x65	2x66	5ht1b_on	0	1.59	No	No	No	Yes	6	5
369	2x39	3x49	5ht1b_on	0	1.54	No	No	Yes	Yes	8	9
370	1x33	1x37	5ht1b_on	0	1.52	No	No	No	No	5	4
371	6x36	6x40	5ht1b_on	0	1.52	No	No	No	No	8	8
372	2x61	2x62	5ht1b_on	0	1.51	No	No	No	No	7	5
373	2x62	2x66	5ht1b_on	0	1.51	No	No	No	Yes	5	5
374	4x52	5x46	5ht1b_on	0	1.51	No	No	No	No	5	4
375	3x22	3x23	5ht1b_on	0	1.43	No	No	No	No	4	1
376	I2x51	I2x52	5ht1b_on	0	1.43	No	No	No	No	6	5
377	4x45	4x48	5ht1b_on	0	1.41	No	No	No	No	6	2
378	5x70	6x26	5ht1b_on	0	1.41	No	No	No	No	0	4
379	3x53	I2x57	5ht1b_on	0	1.38	No	No	No	Yes	7	7
380	8x52	I1x49	5ht1b_on	0	1.36	No	No	No	No	4	6
381	8x47	8x48	5ht1b_on	0	1.31	No	No	No	No	9	6
382	6x31	6x34	5ht1b_on	0	1.29	Yes	No	No	No	6	8
383	5x69	6x29	5ht1b_on	0	1.25	No	No	No	No	5	7
384	1x59	8x57	5ht1b_on	0	1.21	No	No	No	No	6	6

Orange: nodes, hubs and links specific of 5ht1b_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of 5ht1b_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	5ht1b_off Avg Int. Strength	5ht1b_on Avg Int. Strength	5ht1b_off Num Of Links	5ht1b_on Num Of Links	ConSurf
1	NT.Q41	5ht1b_off	10.6475	0	4	0	2
2	1x32	5ht1b_off	4.3475	3.685	4	2	3
3	1x52	5ht1b_off	4.5425	6.43	4	1	7
4	2x56	5ht1b_off	6.9775	6.23667	4	3	7
5	3x32	5ht1b_off	10.2725	8.75	4	3	8
6	3x40	5ht1b_off	6.23	8.425	4	2	8
7	3x52	5ht1b_off	11.175	12.1467	4	3	5
8	4x50	5ht1b_off	6.205	4.37	4	2	9
9	5x58	5ht1b_off	4.07	8.49	5	3	9
10	5x64	5ht1b_off	5.5475	4.895	4	2	6
11	6x31	5ht1b_off	6.37	1.885	4	2	6
12	6x41	5ht1b_off	3.7725	3.38	4	3	8
13	6x49	5ht1b_off	4.5875	3.73667	4	3	6
14	6x58	5ht1b_off	5.285	4.77	4	3	4
15	7x45	5ht1b_off	8.73	9.19667	4	3	9
16	7x48	5ht1b_off	3.6725	2.28	4	2	6
17	2x50	Shared	5.86	6.72	5	5	9
18	2x57	Shared	7.4875	7.77	4	4	7
19	E1x50	Shared	8.41429	6.506	7	5	8
20	3x28	Shared	7.76	8.58	5	4	6
21	3x41	Shared	8.09	8.3475	5	4	6
22	3x42	Shared	9.022	7.302	5	5	7
23	3x49	Shared	7.785	4.6575	4	4	9
24	3x51	Shared	6.11	8.46	4	4	8
25	I2x53	Shared	11.294	10.0475	5	4	8
26	5x47	Shared	11.954	12.3825	5	4	8
27	5x48	Shared	6.956	5.648	5	5	6
28	5x62	Shared	4.3675	8.78	4	4	6
29	6x44	Shared	6.474	4.736	5	5	9
30	6x48	Shared	8.05143	7.27857	7	7	7
31	6x51	Shared	9.238	6.914	5	5	8
32	6x52	Shared	13.994	12.246	5	5	7
33	7x37	Shared	6.2575	6.4725	4	4	6
34	7x39	Shared	9.18714	7.705	7	8	6
35	7x42	Shared	6.35	7.14286	7	7	7
36	7x52	Shared	2.694	3.8225	5	4	8
37	8x50	Shared	5.115	9.468	4	5	8
38	Lig	Shared	7.30154	7.80462	13	13	0
39	1x50	5ht1b_on	8.15	5.515	3	4	9
40	I1x50	5ht1b_on	7.195	6.368	2	5	8
41	2x38	5ht1b_on	6.07667	3.6325	3	4	6
42	2x46	5ht1b_on	4.11	4.63	2	5	9
43	2x51	5ht1b_on	3.675	5.01	2	4	8
44	2x66	5ht1b_on	3.64	2.9775	1	4	5
45	3x34	5ht1b_on	3.68	3.205	3	4	6
46	3x43	5ht1b_on	3.55	7.4	3	4	8
47	3x46	5ht1b_on	4.28	5.53	1	4	9
48	I2x57	5ht1b_on	10.8433	6.425	3	4	7
49	7x34	5ht1b_on	6.89333	7.4375	3	4	4
50	7x49	5ht1b_on	10.175	9.2	2	4	9
51	7x53	5ht1b_on	11.735	6.19	2	5	9

Orange: nodes, hubs and links specific of 5ht1b_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of 5ht1b_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	5ht1b_off Recurrence	5ht1b_on Recurrence	5ht1b_off Hub1?	5ht1b_on Hub1?	5ht1b_off Hub2?	5ht1b_on Hub2?	ConSurf1	ConSurf2
1	1x32	NT.Q41	5ht1b_off	11.5303	0	Yes	No	Yes	No	3	2
2	1x36	2x65	5ht1b_off	29.2381	3.04219	No	No	No	No	6	6
3	1x36	2x61	5ht1b_off	30.3921	0	No	No	No	No	6	7
4	1x46	2x57	5ht1b_off	12.7908	0	No	No	Yes	Yes	7	7
5	7x53	8x50	5ht1b_off	29.8359	0	No	Yes	Yes	Yes	9	8
6	2x43	7x53	5ht1b_off	31.078	4.87273	No	No	No	Yes	8	9
7	2x40	2x43	5ht1b_off	32.51	0	No	No	No	No	9	8
8	2x37	2x39	5ht1b_off	38.0712	0	No	No	No	No	8	8
9	2x39	3x50	5ht1b_off	39.2622	0	No	No	No	No	8	9
10	3x49	3x50	5ht1b_off	41.9872	0	Yes	Yes	No	No	9	9
11	3x52	I2x53	5ht1b_off	62.6981	6.88633	Yes	No	Yes	Yes	5	8
12	3x51	3x52	5ht1b_off	67.5874	0	Yes	Yes	Yes	No	8	5
13	3x41	5x50	5ht1b_off	83.3905	4.57636	Yes	Yes	No	No	6	9
14	3x40	5x50	5ht1b_off	84.7484	0	Yes	No	No	No	8	9
15	3x40	Lig	5ht1b_off	69.6172	0	Yes	No	Yes	Yes	8	0
16	7x42	Lig	5ht1b_off	61.1039	0	Yes	Yes	Yes	Yes	7	0
17	7x54	8x50	5ht1b_off	15.0987	2.44073	No	No	Yes	Yes	7	8
18	7x54	8x54	5ht1b_off	10.6683	0	No	No	No	No	7	7
19	I2x53	I2x57	5ht1b_off	13.9679	1.31625	Yes	Yes	No	Yes	8	7
20	2x49	3x42	5ht1b_off	11.9195	6.84275	No	No	Yes	Yes	8	7
21	2x49	3x38	5ht1b_off	12.2671	0	No	No	No	No	8	8
22	3x38	4x53	5ht1b_off	27.5976	0	No	No	No	No	8	8
23	3x42	4x50	5ht1b_off	15.8078	0	Yes	Yes	Yes	No	7	9
24	3x38	4x50	5ht1b_off	15.3721	2.29254	No	No	Yes	No	8	9
25	6x44	7x45	5ht1b_off	10.7332	0	Yes	Yes	Yes	No	9	9
26	6x48	7x42	5ht1b_off	14.1533	0	Yes	Yes	Yes	Yes	7	7
27	E1x50	E1x52	5ht1b_off	10.8954	6.91248	Yes	Yes	No	No	8	6
28	3x28	E1x50	5ht1b_off	42.3626	0	Yes	Yes	Yes	Yes	6	8
29	2x63	E2.E198	5ht1b_off	10.5478	6.91248	No	No	No	No	6	4
30	3x30	4x61	5ht1b_off	31.8426	6.77301	No	No	No	No	7	7
31	3x30	4x57	5ht1b_off	33.9327	9.144	No	No	No	No	7	7
32	3x40	5x47	5ht1b_off	10.7424	0	Yes	No	Yes	Yes	8	8
33	3x44	5x54	5ht1b_off	26.9858	0	No	No	No	No	7	8
34	4x59	4x60	5ht1b_off	21.8232	0.0610181	No	No	No	No	7	7
35	4x60	4x61	5ht1b_off	23.955	0	No	No	No	No	7	7
36	4x59	5x39	5ht1b_off	19.6821	0.148187	No	No	No	No	7	8
37	4x63	5x36	5ht1b_off	11.0205	0	No	No	No	No	6	6
38	5x36	5x38	5ht1b_off	13.2033	0	No	No	No	No	6	3
39	5x38	5x39	5ht1b_off	17.5317	0.0610181	No	No	No	No	3	8
40	5x54	6x41	5ht1b_off	25.5353	8.46409	No	No	Yes	No	8	8
41	5x58	6x41	5ht1b_off	19.6172	0	Yes	No	Yes	No	9	8
42	5x58	5x62	5ht1b_off	13.7501	0	Yes	No	Yes	Yes	9	6
43	3x43	6x40	5ht1b_off	13.0318	0	No	Yes	No	No	8	8
44	6x51	Lig	5ht1b_off	16.6559	0.470711	Yes	Yes	Yes	Yes	8	0
45	6x54	7x34	5ht1b_off	13.8891	0	No	No	No	Yes	4	4
46	6x51	7x34	5ht1b_off	27.5373	5.77929	Yes	Yes	No	Yes	8	4
47	6x58	7x34	5ht1b_off	12.1281	0	Yes	No	No	Yes	4	4
48	1x29	1x32	Shared	10.2465	21.121	No	No	Yes	No	3	3
49	1x32	2x65	Shared	25.2896	24.0673	Yes	No	No	No	3	6
50	2x61	7x39	Shared	31.4487	50.3225	No	No	Yes	Yes	7	6
51	2x57	7x39	Shared	15.7661	24.3724	Yes	Yes	Yes	Yes	7	6
52	1x50	2x50	Shared	13.5647	40.9955	No	Yes	Yes	Yes	9	9
53	2x37	2x40	Shared	36.6948	43.6367	No	No	No	No	8	9
54	3x49	I2x53	Shared	45.4676	10.0244	Yes	Yes	Yes	Yes	9	8
55	3x51	5x57	Shared	79.3864	19.7699	Yes	Yes	No	No	8	6
56	5x53	5x57	Shared	81.5182	24.0411	No	No	No	No	7	6
57	3x44	5x53	Shared	82.5424	26.1506	No	No	No	No	7	7
58	3x41	3x44	Shared	100	28.2427	Yes	Yes	No	No	6	7
59	7x39	7x42	Shared	39.7535	42.887	Yes	Yes	Yes	Yes	6	7
60	2x38	I2x57	Shared	13.9633	63.4327	No	Yes	No	Yes	6	7
61	3x37	4x53	Shared	34.2015	20.6939	No	No	No	No	7	8
62	3x37	Lig	Shared	36.2499	25.0959	No	No	Yes	Yes	7	0
63	3x42	4x49	Shared	27.3149	53.8529	Yes	Yes	No	No	7	7
64	3x41	4x49	Shared	30.0399	44.3515	Yes	Yes	No	No	6	7
65	3x43	6x44	Shared	19.9045	41.9718	No	Yes	Yes	Yes	8	9
66	3x40	6x44	Shared	25.1413	16.1698	Yes	No	Yes	Yes	8	9
67	7x45	7x49	Shared	10.0751	47.1409	Yes	No	No	Yes	9	9
68	2x56	7x42	Shared	21.4524	18.9941	Yes	No	Yes	Yes	7	7
69	2x60	3x28	Shared	21.3551	20.9902	No	No	Yes	Yes	6	6
70	2x63	E1x50	Shared	14.1672	10.3469	No	No	Yes	Yes	6	8
71	3x34	4x57	Shared	36.0089	11.4888	No	Yes	No	No	6	7
72	3x34	4x53	Shared	44.221	18.4188	No	Yes	No	No	6	8
73	2x56	3x28	Shared	34.7901	28.0073	Yes	No	Yes	Yes	7	6
74	2x56	3x32	Shared	16.2851	11.0007	Yes	No	Yes	No	7	8
75	2x60	7x42	Shared	19.024	19.395	No	No	Yes	Yes	6	7
76	3x32	Lig	Shared	16.8598	27.7894	Yes	No	Yes	Yes	8	0
77	1x29	1x30	5ht1b_on	7.36398	10.6346	No	No	No	No	3	3
78	2x65	2x66	5ht1b_on	0	30.4393	No	No	No	Yes	6	5
79	2x62	2x66	5ht1b_on	0	43.9679	No	No	No	Yes	5	5
80	2x61	2x62	5ht1b_on	0	47.3065	No	No	No	No	7	5
81	2x53	2x57	5ht1b_on	4.4119	27.9289	No	No	Yes	Yes	8	7
82	2x53	7x46	5ht1b_on	6.22857	92.3727	No	No	No	No	8	9
83	2x50	7x46	5ht1b_on	5.40829	92.7911	Yes	Yes	No	No	9	9
84	1x50	2x51	5ht1b_on	0	31.1628	No	Yes	No	Yes	9	8
85	2x51	2x54	5ht1b_on	4.60654	13.2845	No	Yes	No	No	8	7
86	2x53	7x42	5ht1b_on	0	64.5833	No	No	Yes	Yes	8	7
87	2x46	2x50	5ht1b_on	7.22032	92.4948	No	Yes	Yes	Yes	9	9
88	2x46	3x46	5ht1b_on	0	100	No	Yes	No	Yes	9	9
89	2x42	3x46	5ht1b_on	1.55251	81.4766	No	No	No	Yes	7	9
90	2x42	3x49	5ht1b_on	4.398	79.681	No	No	Yes	Yes	7	9
91	3x49	I2x57	5ht1b_on	1.51543	66.0565	Yes	Yes	No	Yes	9	7
92	2x37	2x38	5ht1b_on	0	45.7287	No	No	No	Yes	8	6
93	2x40	I1x50	5ht1b_on	0	35.2162	No	No	No	Yes	9	8
94	8x50	I1x50	5ht1b_on	0	20.1534	Yes	Yes	No	Yes	8	8
95	8x50	8x54	5ht1b_on	0	11.4017	Yes	Yes	No	No	8	7
96	2x38	4x39	5ht1b_on	7.87376	16.3877	No	Yes	No	No	6	3
97	2x41	4x39	5ht1b_on	0.0648809	11.698	No	No	No	No	5	3
98	2x46	3x42	5ht1b_on	0	64.6792	No	Yes	Yes	Yes	9	7
99	2x46	3x43	5ht1b_on	7.78571	25.1656	No	Yes	No	Yes	9	8
100	2x50	7x49	5ht1b_on	9.15748	18.1747	Yes	Yes	No	Yes	9	9
101	3x43	7x49	5ht1b_on	0	19.0551	No	Yes	No	Yes	8	9
102	2x51	2x55	5ht1b_on	4.24043	10.6607	No	Yes	No	No	8	5
103	3x32	7x42	5ht1b_on	0.407823	16.4662	Yes	No	Yes	Yes	8	7
104	3x28	3x29	5ht1b_on	6.8542	43.1311	Yes	Yes	No	No	6	6
105	3x29	E2x50	5ht1b_on	3.27649	39.871	No	No	No	No	6	9
106	E1x50	E2x50	5ht1b_on	3.67504	33.8128	Yes	Yes	No	No	8	9
107	3x21	E1x50	5ht1b_on	3.6426	13.7639	No	No	Yes	Yes	6	8
108	3x21	3x22	5ht1b_on	0	10.3469	No	No	No	No	6	4
109	6x48	Lig	5ht1b_on	3.44332	44.0377	Yes	Yes	Yes	Yes	7	0
110	7x38	7x42	5ht1b_on	6.74298	11.0704	No	No	Yes	Yes	6	7
111	6x51	7x38	5ht1b_on	6.45101	10.3556	Yes	Yes	No	No	8	6
112	6x48	6x51	5ht1b_on	7.55862	10.068	Yes	Yes	Yes	Yes	7	8
113	3x40	6x48	5ht1b_on	0	15.7165	Yes	No	Yes	Yes	8	7
114	3x41	4x52	5ht1b_on	4.79192	11.3232	Yes	Yes	No	No	6	5
115	3x43	7x53	5ht1b_on	0	41.0303	No	Yes	No	Yes	8	9
116	3x46	7x53	5ht1b_on	0	16.2221	No	Yes	No	Yes	9	9
117	3x46	3x50	5ht1b_on	0	31.5202	No	Yes	No	No	9	9
118	3x50	5x58	5ht1b_on	0	44.8396	No	No	Yes	No	9	9
119	3x51	3x55	5ht1b_on	7.64668	13.2235	Yes	Yes	No	No	8	7
120	6x52	Lig	5ht1b_on	7.85522	14.0429	Yes	Yes	Yes	Yes	7	0
121	5x47	6x52	5ht1b_on	5.56585	16.9456	Yes	Yes	Yes	Yes	8	7
122	5x47	5x48	5ht1b_on	3.6426	14.4874	Yes	Yes	Yes	Yes	8	6
123	5x47	5x51	5ht1b_on	2.74817	11.1576	Yes	Yes	No	No	8	6
124	5x54	6x44	5ht1b_on	0	11.2535	No	No	Yes	Yes	8	9
125	5x58	6x37	5ht1b_on	0	32.7319	Yes	No	No	No	9	8
126	5x58	6x40	5ht1b_on	0	10.6084	Yes	No	No	No	9	8
127	5x62	6x37	5ht1b_on	0	30.4045	Yes	Yes	No	No	6	8
128	5x62	6x30	5ht1b_on	0	16.8149	Yes	Yes	No	No	6	8
129	7x52	7x53	5ht1b_on	0	18.6018	Yes	Yes	No	Yes	8	9
130	6x44	6x45	5ht1b_on	3.16063	13.9644	Yes	Yes	No	No	9	6
131	6x45	6x49	5ht1b_on	1.63129	12.3692	No	No	Yes	No	6	6
132	6x48	7x45	5ht1b_on	8.74502	46.984	Yes	Yes	Yes	No	7	9
133	6x49	6x50	5ht1b_on	5.42219	16.4139	Yes	No	No	No	6	9
134	6x50	7x37	5ht1b_on	3.2116	11.0094	No	No	Yes	Yes	9	6
135	7x34	7x35	5ht1b_on	0	10.5038	No	Yes	No	No	4	4
136	6x58	Lig	5ht1b_on	0	11.8898	Yes	No	Yes	Yes	4	0
137	6x30	6x33	5ht1b_on	1.60349	14.4439	No	No	No	No	8	8
138	5x69	6x33	5ht1b_on	0	11.5673	No	No	No	No	5	8
139	5x51	6x44	5ht1b_on	2.20132	11.698	No	No	Yes	Yes	6	9
140	2x46	7x49	5ht1b_on	0	30.4829	No	Yes	No	Yes	9	9
141	3x50	7x53	5ht1b_on	0	15.6904	No	No	No	Yes	9	9

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
2x53	2x56	5ht1b_off	4.81	0	0	1	2	2
2x53	2x57	Shared	4.56	4.56	0	1	2	2
2x56	3x32	Shared	13.15	8.76	1	1	2	1
2x56	7x42	Shared	5.05	5.05	1	1	2	1
2x57	7x39	Shared	5.82	5.82	0	1	2	2
2x60	7x39	Shared	8.65	9.88	1	1	2	2
2x60	7x42	Shared	6.36	6.36	1	1	2	1
3x32	3x36	5ht1b_off	4.67	0	1	1	1	1
3x32	7x42	Shared	11.49	9.2	1	1	1	1
3x32	Lig	Shared	11.78	8.29	1	1	1	0
3x33	Lig	Shared	4.77	16.46	0	0	1	0
3x36	6x48	Shared	3.92	6.53	1	1	1	1
3x36	Lig	Shared	5.3	5.38	1	1	1	0
3x37	4x53	Shared	6.4	6.4	0	0	1	2
3x37	5x461	Shared	5.03	5.03	0	0	1	2
3x37	Lig	Shared	4.92	5	0	0	1	0
3x40	5x47	5ht1b_off	3.77	0	0	0	1	2
3x40	5x50	5ht1b_off	5.08	0	0	0	1	2
3x40	6x44	Shared	11.3	6.28	0	0	1	2
3x40	Lig	5ht1b_off	4.77	0	0	0	1	0
E2x52	Lig	Shared	3.98	7.07	0	0	1	0
5x44	5x48	Shared	6.24	3.75	0	0	1	2
5x44	Lig	5ht1b_off	3.94	0	0	0	1	0
5x47	5x48	Shared	11.35	12.38	1	0	2	2
5x47	6x52	Shared	33.22	25.72	1	0	2	1
5x48	6x52	5ht1b_off	6.19	0	1	0	2	1
5x48	6x56	Shared	4.69	4.69	1	0	2	2
6x44	7x45	5ht1b_off	8.46	0	0	0	2	2
6x48	6x51	Shared	9.02	6.01	1	1	1	1
6x48	6x52	Shared	6.01	11.02	1	1	1	1
6x48	7x41	Shared	12.67	8.44	1	1	1	2
6x48	7x42	5ht1b_off	3.86	0	1	1	1	1
6x48	7x45	Shared	3.39	4.52	1	1	1	2
6x48	Lig	Shared	17.49	3.86	1	1	1	0
6x51	6x52	Shared	10.72	6.43	1	1	1	1
6x51	7x34	Shared	3.22	7.5	1	1	1	1
6x51	7x38	Shared	7.78	3.89	1	1	1	2
6x51	Lig	Shared	15.45	10.74	1	1	1	0
6x52	Lig	Shared	13.83	11.57	1	1	1	0
6x54	7x30	5ht1b_off	3.98	0	0	0	2	2
6x54	7x34	5ht1b_off	5.02	0	0	0	2	1
6x58	6x59	Shared	3.35	1.68	0	0	1	2
6x58	7x30	5ht1b_off	3.94	0	0	0	1	2
6x58	7x34	5ht1b_off	12.44	0	0	0	1	1
7x38	7x42	Shared	6.24	3.75	0	1	2	1
7x39	7x42	Shared	6.75	8.68	1	1	2	1
7x42	Lig	5ht1b_off	4.7	0	1	1	1	0
5x43	Lig	5ht1b_off	3.01	0	0	0	1	0
6x55	6x56	5ht1b_off	3	0	0	0	1	2
6x58	7x31	5ht1b_off	1.41	0	0	0	1	2
5x40	Lig	Shared	0.98	3	0	0	1	0
2x53	7x42	5ht1b_on	0	3.79	0	1	2	1
2x57	7x42	5ht1b_on	0	13.17	0	1	2	1
3x40	6x48	5ht1b_on	0	10.57	0	0	1	1
5x44	6x52	5ht1b_on	0	6.49	0	0	1	1
5x44	6x55	5ht1b_on	0	7.99	0	0	1	1
6x55	Lig	5ht1b_on	0	6.11	0	0	1	0
6x58	Lig	5ht1b_on	0	9.59	0	0	1	0
7x31	7x35	5ht1b_on	0	4.07	0	0	2	2
7x34	7x35	5ht1b_on	0	5.97	0	1	1	2
7x34	7x38	5ht1b_on	0	3.89	0	1	1	2
7x34	Lig	5ht1b_on	0	12.39	0	1	1	0
4x56	5x43	5ht1b_on	0	3.1	0	0	2	1
6x57	6x58	5ht1b_on	0	3.04	0	0	2	1
E2.T203	Lig	5ht1b_on	0	2	0	0	1	0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	5ht1b_off	5V54-5-HT_1B-Methiothepin
	5ht1b_on	6G79-5-HT_1B-Donitriptan-Go/&β;1/&γ;2

Network Difference
Value	5ht1b_off	5ht1b_on
I_min	3.17	3.64
Number of Linked Nodes	252	231
Number of Specific Nodes	31 (12.30%)	10 (4.33%)
Number of Shared Nodes	221 (87.70%)	221 (95.67%)
Number of Links	290	260
Number of Specific Links	124 (42.76%)	94 (36.15%)
Number of Shared Links	166 (57.24%)	166 (63.85%)
Number of Hubs	38	35
Number of Specific Hubs	16 (42.11%)	13 (37.14%)
Number of Shared Hubs	22 (57.89%)	22 (62.86%)
Average % Shared Neighbours (Jaccard)	43.07
Average % Shared Neighbours (Otsuka)	51.36
Average % Shared Neighbours (Overlap Coefficient)	60.23
Average % Shared Cliques (k3-6)	82.43
Graphlets Similarity	0.654237

Paths Difference
Value	5ht1b_off	5ht1b_on
Number Of Nodes in MetaPath	74	85
Specific Nodes in MetaPath	23 (31.08%)	34 (40.00%)
Shared Nodes in MetaPath	221 (87.70%)	221 (87.70%)
Number Of Links MetaPath	76	94
Specific Links in MetaPath	47 (61.84%)	65 (69.15%)
Shared Links in MetaPath	166 (57.24%)	166 (57.24%)
Number of Shortest Paths	49799	35081
Length Of Smallest Path	3	3
Average Path Length	13.8798	12.0787
Length of Longest Path	40	28
Minimum Path Strength	1.435	1.45
Average Path Strength	6.29494	6.06676
Maximum Path Strength	23.525	19.05
Minimum Path Correlation	0.7	0.7
Average Path Correlation	0.929929	0.909867
Maximum Path Correlation	0.99	0.99
Minimum % Of Corr. Nodes	3.57143	4
Average % Of Corr. Nodes	50.3104	47.1346
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	42.9247	48.381
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 5ht1b_off_on.zip<

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