psnGPCR

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Orange: nodes, hubs and links specific of 5ht2_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of 5ht2_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	5ht2_off Int. Strength	5ht2_on Int. Strength	5ht2_off Hub1?	5ht2_on Hub1?	5ht2_off Hub2?	5ht2_on Hub2?	ConSurf1	ConSurf2
1	1x51	2x51	5ht2_off	100	0	No	No	No	No	3	7
2	1x53	8x54	5ht2_off	100	0	No	No	Yes	No	9	6
3	1x60	8x56	5ht2_off	100	0	Yes	No	No	No	6	4
4	1x60	8x57	5ht2_off	100	0	Yes	No	Yes	No	6	4
5	I1x48	I1x51	5ht2_off	100	0	No	No	No	No	6	7
6	8x49	I1x49	5ht2_off	100	0	No	No	No	No	6	6
7	8x49	I1x50	5ht2_off	100	0	No	No	Yes	No	6	8
8	2x37	2x40	5ht2_off	100	0	No	No	No	No	7	9
9	2x41	4x39	5ht2_off	100	0	No	No	Yes	No	4	4
10	2x42	4x46	5ht2_off	100	0	Yes	Yes	No	No	8	8
11	2x43	7x53	5ht2_off	100	0	No	No	No	Yes	8	9
12	2x56	3x28	5ht2_off	100	0	Yes	No	No	No	8	5
13	2x57	7x39	5ht2_off	100	0	Yes	Yes	Yes	Yes	8	6
14	2x57	7x42	5ht2_off	100	0	Yes	Yes	Yes	Yes	8	7
15	2x64	E1	5ht2_off	100	0	No	No	No	No	5	3
16	E1x50	E1x51	5ht2_off	100	0	Yes	No	No	No	7	3
17	3x25	E1x50	5ht2_off	100	0	No	No	Yes	No	9	7
18	3x28	E1x50	5ht2_off	100	0	No	No	Yes	No	5	7
19	E1x50	E2	5ht2_off	100	0	Yes	No	Yes	Yes	7	3
20	3x21	E1x52	5ht2_off	100	0	No	No	No	No	7	5
21	3x22	E2	5ht2_off	100	0	No	No	Yes	Yes	3	3
22	3x26	E2	5ht2_off	100	0	No	No	Yes	Yes	6	3
23	3x29	4x61	5ht2_off	100	0	No	No	Yes	No	5	6
24	3x33	4x57	5ht2_off	100	0	No	No	No	No	6	7
25	3x33	4x61	5ht2_off	100	0	No	No	Yes	No	6	6
26	3x35	4x50	5ht2_off	100	0	Yes	Yes	Yes	Yes	7	9
27	3x37	4x53	5ht2_off	100	0	No	No	No	No	7	8
28	3x39	6x44	5ht2_off	100	0	No	No	Yes	No	9	9
29	3x40	6x44	5ht2_off	100	0	No	No	Yes	No	8	9
30	3x41	5x50	5ht2_off	100	0	No	No	Yes	No	6	9
31	3x43	6x44	5ht2_off	100	0	No	No	Yes	No	8	9
32	3x44	5x53	5ht2_off	100	0	No	No	No	No	6	6
33	3x54	5x64	5ht2_off	100	0	No	No	No	No	9	6
34	3x54	6x30	5ht2_off	100	0	No	No	Yes	Yes	9	8
35	4x38	4x41	5ht2_off	100	0	No	No	No	Yes	7	6
36	4x39	4x43	5ht2_off	100	0	Yes	No	No	No	4	4
37	4x60	5x39	5ht2_off	100	0	No	No	No	No	7	7
38	5x36	5x39	5ht2_off	100	0	Yes	No	No	No	5	7
39	5x51	6x45	5ht2_off	100	0	No	No	No	No	6	6
40	6x31	6x35	5ht2_off	100	0	No	No	No	No	5	7
41	6x40	7x49	5ht2_off	100	0	No	No	Yes	No	8	9
42	6x42	6x46	5ht2_off	100	0	No	No	No	No	5	5
43	6x44	7x45	5ht2_off	100	0	Yes	No	No	No	9	9
44	6x48	6x51	5ht2_off	100	0	Yes	Yes	Yes	Yes	8	7
45	6x48	6x52	5ht2_off	100	0	Yes	Yes	Yes	Yes	8	7
46	6x48	Lig	5ht2_off	100	0	Yes	Yes	Yes	Yes	8	0
47	6x51	6x55	5ht2_off	100	0	Yes	Yes	No	No	7	7
48	6x55	7x34	5ht2_off	100	0	No	No	No	No	7	3
49	7x53	8x50	5ht2_off	100	0	No	Yes	Yes	Yes	9	8
50	8x50	8x54	5ht2_off	100	0	Yes	Yes	Yes	No	8	6
51	8x53	8x57	5ht2_off	100	0	No	No	Yes	No	7	4
52	8x56	CT	5ht2_off	100	0	No	No	Yes	No	4	5
53	8x57	CT	5ht2_off	100	0	Yes	No	Yes	No	4	5
54	3x43	6x41	5ht2_off	100	0	No	No	Yes	Yes	8	8
55	3x46	6x41	5ht2_off	100	0	No	No	Yes	Yes	9	8
56	3x47	6x41	5ht2_off	100	0	No	No	Yes	Yes	9	8
57	3x50	6x30	5ht2_off	100	0	Yes	No	Yes	Yes	9	8
58	5x47	Lig	5ht2_off	100	0	No	Yes	Yes	Yes	8	0
59	5x58	5x59	5ht2_off	100	0	Yes	No	No	No	9	1
60	6x37	6x41	5ht2_off	100	0	No	No	Yes	Yes	8	8
61	1x60	CT	5ht2_off	100	0	Yes	No	Yes	No	6	5
62	3x41	4x52	5ht2_off	100	0	No	No	No	No	6	5
63	7x27	E2	5ht2_off	100	0	No	No	Yes	Yes	3	3
64	E2x51	Lig	5ht2_off	100	0	No	No	Yes	Yes	4	0
65	CT	CT	5ht2_off	100	0	Yes	No	Yes	No	5	5
66	NT	NT	5ht2_off	100	0	Yes	No	Yes	No	0	0
67	1x33	NT	5ht2_off	100	0	No	No	Yes	No	5	0
68	1x32	1x35	5ht2_off	100	0	No	No	Yes	No	6	3
69	1x34	1x35	5ht2_off	100	0	No	No	Yes	No	4	3
70	4x64	5x36	5ht2_off	100	0	No	No	Yes	No	4	5
71	5x63	5x67	5ht2_off	100	0	No	No	No	No	4	5
72	6x44	7x49	5ht2_off	100	0	Yes	No	Yes	No	9	9
73	2x66	NT	5ht2_off	100	0	No	No	Yes	No	4	0
74	2x67	NT	5ht2_off	100	0	No	No	Yes	No	5	0
75	5x40	E2x52	5ht2_off	50	0	No	No	No	No	6	4
76	8x60	CT	5ht2_off	66.6667	0	No	No	Yes	No	8	5
77	2x62	E1x51	5ht2_off	66.6667	0	No	No	No	No	4	3
78	2x39	3x50	5ht2_off	66.6667	0	No	No	Yes	No	8	9
79	5x69	6x27	5ht2_off	38.8889	0	No	No	Yes	No	5	5
80	7x55	7x56	5ht2_off	66.6667	0	No	No	Yes	No	5	7
81	2x55	2x551	5ht2_off	38.8889	0	No	No	No	No	4	5
82	6x39	7x56	5ht2_off	66.6667	0	No	No	Yes	No	6	7
83	1x42	2x57	5ht2_off	16.6667	0	No	No	Yes	Yes	7	8
84	1x54	2x44	5ht2_off	33.3333	0	No	No	No	No	6	5
85	3x50	6x34	5ht2_off	44.4444	0	Yes	No	No	No	9	7
86	7x29	7x33	5ht2_off	33.3333	0	No	No	No	No	5	4
87	1x49	7x50	5ht2_off	66.6667	0	No	No	No	No	8	9
88	1x48	1x51	5ht2_off	50	0	No	No	No	No	4	3
89	5x61	5x65	5ht2_off	0	0	No	No	No	Yes	9	8
90	6x54	7x30	5ht2_off	0	0	No	No	No	No	5	4
91	8x59	CT	5ht2_off	33.3333	0	No	No	Yes	No	4	5
92	4x59	4x63	5ht2_off	33.3333	0	No	No	No	No	4	5
93	CT	I1x48	5ht2_off	33.3333	0	Yes	No	No	No	5	6
94	5x54	6x45	5ht2_off	33.3333	0	No	No	No	No	8	6
95	5x41	5x42	5ht2_off	33.3333	0	Yes	No	No	No	6	4
96	3x23	3x24	5ht2_off	33.3333	0	No	No	No	No	1	5
97	I2x51	I2x52	5ht2_off	50	0	No	No	No	No	7	5
98	2x65	2x66	5ht2_off	33.3333	0	No	No	No	No	5	4
99	1x58	2x44	5ht2_off	5.55556	0	No	No	No	No	1	5
100	5x63	5x66	5ht2_off	55.5556	0	No	No	No	No	4	6
101	3x50	6x33	5ht2_off	44.4444	0	Yes	No	No	No	9	8
102	1x40	2x61	5ht2_off	0	0	No	No	No	No	3	6
103	7x54	8x51	5ht2_off	44.4444	0	No	Yes	No	No	7	9
104	1x40	1x44	5ht2_off	0	0	No	No	No	No	3	4
105	4x56	5x46	5ht2_off	27.7778	0	No	No	No	No	6	4
106	5x51	5x55	5ht2_off	33.3333	0	No	No	No	No	6	5
107	5x41	6x56	5ht2_off	33.3333	0	Yes	No	No	No	6	5
108	7x52	7x56	5ht2_off	0	0	No	No	Yes	No	8	7
109	E2	E3	5ht2_off	38.8889	0	Yes	Yes	No	Yes	3	3
110	5x65	6x31	5ht2_off	33.3333	0	No	Yes	No	No	8	5
111	5x68	6x27	5ht2_off	33.3333	0	No	No	Yes	No	7	5
112	I2x54	I2x57	5ht2_off	38.8889	0	No	No	No	No	6	6
113	5x59	5x63	5ht2_off	33.3333	0	No	No	No	No	1	4
114	3x48	3x52	5ht2_off	16.6667	0	No	No	No	No	6	5
115	6x43	7x48	5ht2_off	5.55556	0	No	No	No	No	6	6
116	2x41	4x42	5ht2_off	11.1111	0	No	No	No	No	4	7
117	1x36	2x65	5ht2_off	5.55556	0	No	No	No	No	6	5
118	I2x52	I2x53	5ht2_off	11.1111	0	No	No	No	Yes	5	7
119	6x28	6x32	5ht2_off	0	0	No	No	No	No	6	8
120	5x43	Lig	5ht2_off	0	0	No	No	Yes	Yes	6	0
121	4x39	I2x56	5ht2_off	5.55556	0	Yes	No	No	No	4	4
122	2x38	4x38	5ht2_off	0	0	No	No	No	No	5	7
123	1x33	1x37	5ht2_off	33.3333	0	No	No	No	No	5	4
124	1x44	1x45	5ht2_off	33.3333	0	No	No	No	No	4	4
125	4x55	4x59	5ht2_off	0	0	No	No	No	No	4	4
126	6x45	6x46	5ht2_off	0	0	No	No	No	No	6	5
127	7x32	7x35	5ht2_off	0	0	No	No	No	No	1	4
128	1x35	2x64	5ht2_off	0	0	Yes	No	No	No	3	5
129	6x57	6x60	5ht2_off	0	0	No	No	No	No	4	4
130	6x26	6x30	5ht2_off	16.6667	0	No	No	Yes	Yes	5	8
131	1x35	1x38	5ht2_off	0	0	Yes	No	No	No	3	4
132	1x28	1x32	5ht2_off	5.55556	0	No	No	No	No	3	6
133	3x50	3x53	5ht2_off	5.55556	0	Yes	No	No	No	9	8
134	1x29	1x33	5ht2_off	5.55556	0	No	No	No	No	3	5
135	1x28	1x31	5ht2_off	11.1111	0	No	No	No	No	3	3
136	1x27	1x30	5ht2_off	11.1111	0	No	No	No	No	2	1
137	6x27	6x28	5ht2_off	0	0	Yes	No	No	No	5	6
138	1x41	1x411	5ht2_off	0	0	No	No	No	No	4	0
139	3x24	3x27	5ht2_off	0	0	No	No	No	No	5	4
140	1x30	1x32	5ht2_off	5.55556	0	No	No	No	No	1	6
141	6x24	I3	5ht2_off	0	0	No	No	No	No	0	0
142	1x39	2x61	Shared	100	100	No	Yes	No	No	6	6
143	1x39	7x39	Shared	100	100	No	Yes	Yes	Yes	6	6
144	1x42	7x43	Shared	100	25	No	No	No	No	7	4
145	1x43	2x57	Shared	100	100	No	No	Yes	Yes	6	8
146	1x46	2x57	Shared	100	100	No	No	Yes	Yes	7	8
147	1x46	7x47	Shared	100	100	No	No	No	No	7	6
148	1x47	2x55	Shared	100	100	No	No	No	No	5	4
149	1x50	2x47	Shared	100	25	No	Yes	No	No	9	9
150	1x50	2x50	Shared	100	100	No	Yes	Yes	Yes	9	9
151	1x50	7x50	Shared	100	100	No	Yes	No	No	9	9
152	1x52	8x54	Shared	100	100	No	No	Yes	No	6	6
153	1x55	8x57	Shared	100	100	No	No	Yes	No	4	4
154	1x57	2x44	Shared	100	100	No	No	No	No	7	5
155	1x59	8x57	Shared	100	100	No	No	Yes	No	5	4
156	1x60	I1x50	Shared	100	50	Yes	No	Yes	No	6	8
157	2x40	I1x50	Shared	100	100	No	No	Yes	No	9	8
158	8x50	I1x50	Shared	100	100	Yes	Yes	Yes	No	8	8
159	2x41	I1x51	Shared	100	100	No	No	No	No	4	7
160	2x40	8x50	Shared	100	100	No	No	Yes	Yes	9	8
161	2x42	3x46	Shared	100	100	Yes	Yes	No	No	8	9
162	2x42	4x45	Shared	100	100	Yes	Yes	No	No	8	6
163	2x45	3x42	Shared	100	100	No	No	Yes	Yes	9	8
164	2x45	4x46	Shared	100	100	No	No	No	No	9	8
165	2x45	4x50	Shared	100	100	No	No	Yes	Yes	9	9
166	2x46	2x50	Shared	100	100	No	No	Yes	Yes	9	9
167	2x50	3x39	Shared	100	50	Yes	Yes	No	No	9	9
168	2x50	7x46	Shared	100	100	Yes	Yes	No	No	9	9
169	2x52	3x35	Shared	100	100	No	No	Yes	Yes	7	7
170	2x53	2x56	Shared	100	100	No	Yes	Yes	No	7	8
171	2x53	3x35	Shared	100	100	No	Yes	Yes	Yes	7	7
172	2x53	7x46	Shared	100	100	No	Yes	No	No	7	9
173	2x54	2x57	Shared	100	100	No	No	Yes	Yes	6	8
174	2x56	3x32	Shared	100	100	Yes	No	No	No	8	8
175	2x56	7x42	Shared	100	100	Yes	No	Yes	Yes	8	7
176	2x59	3x28	Shared	100	100	No	No	No	No	4	5
177	2x60	7x39	Shared	100	100	No	No	Yes	Yes	7	6
178	2x64	7x39	Shared	100	100	No	No	Yes	Yes	5	6
179	2x66	E1x51	Shared	100	100	No	No	No	No	4	3
180	7x35	E1	Shared	100	100	No	No	No	No	4	3
181	E1x50	E1x52	Shared	100	50	Yes	No	No	No	7	5
182	E1x50	E2x50	Shared	100	100	Yes	No	No	No	7	9
183	3x24	E1x52	Shared	100	50	No	No	No	No	5	5
184	3x25	E2	Shared	100	100	No	No	Yes	Yes	9	3
185	3x25	E2x50	Shared	100	100	No	No	No	No	9	9
186	3x30	4x62	Shared	100	100	No	Yes	No	No	6	5
187	3x31	3x35	Shared	100	100	No	No	Yes	Yes	5	7
188	3x32	7x42	Shared	100	100	No	No	Yes	Yes	8	7
189	3x32	Lig	Shared	100	100	No	No	Yes	Yes	8	0
190	3x33	Lig	Shared	100	100	No	No	Yes	Yes	6	0
191	3x34	3x35	Shared	100	100	No	No	Yes	Yes	6	7
192	3x34	4x57	Shared	100	100	No	No	No	No	6	7
193	3x36	Lig	Shared	100	100	No	No	Yes	Yes	7	0
194	3x37	5x461	Shared	100	100	No	No	No	No	7	6
195	3x38	4x50	Shared	100	100	No	No	Yes	Yes	8	9
196	3x38	4x53	Shared	100	100	No	No	No	No	8	8
197	3x40	5x50	Shared	100	100	No	No	Yes	No	8	9
198	3x42	4x49	Shared	100	100	Yes	Yes	No	No	8	6
199	3x42	4x50	Shared	100	100	Yes	Yes	Yes	Yes	8	9
200	3x47	5x57	Shared	100	100	No	No	No	No	9	5
201	3x49	4x45	Shared	100	100	No	No	No	No	9	6
202	3x50	6x37	Shared	100	100	Yes	No	No	No	9	8
203	3x51	3x55	Shared	100	100	No	Yes	No	No	8	6
204	3x51	5x60	Shared	100	100	No	Yes	No	No	8	5
205	3x51	5x61	Shared	100	100	No	Yes	No	No	8	9
206	3x54	5x65	Shared	100	100	No	No	No	Yes	9	8
207	I2x55	I2x56	Shared	100	50	No	No	No	No	4	4
208	4x41	4x45	Shared	100	100	No	Yes	No	No	6	6
209	4x59	4x60	Shared	100	100	No	No	No	No	4	7
210	4x61	4x62	Shared	100	100	Yes	No	No	No	6	5
211	4x61	5x39	Shared	100	100	Yes	No	No	No	6	7
212	4x64	E2	Shared	100	100	No	No	Yes	Yes	4	3
213	4x68	E2	Shared	100	100	No	No	Yes	Yes	4	3
214	E2	E2	Shared	100	100	Yes	Yes	Yes	Yes	3	3
215	5x36	E2	Shared	100	100	Yes	No	Yes	Yes	5	3
216	E2	E2x51	Shared	100	100	Yes	Yes	No	No	3	4
217	5x40	6x55	Shared	100	100	No	No	No	No	6	7
218	5x44	6x52	Shared	100	100	No	No	Yes	Yes	6	7
219	5x45	5x48	Shared	100	100	No	No	No	No	4	5
220	5x47	5x48	Shared	100	100	No	Yes	No	No	8	5
221	5x47	6x52	Shared	100	100	No	Yes	Yes	Yes	8	7
222	5x49	5x50	Shared	100	100	No	No	Yes	No	5	9
223	5x54	6x41	Shared	100	50	No	No	Yes	Yes	8	8
224	5x58	5x62	Shared	100	100	Yes	No	No	No	9	5
225	5x58	6x38	Shared	100	100	Yes	No	No	No	9	6
226	5x68	6x30	Shared	100	100	No	No	Yes	Yes	7	8
227	6x25	6x29	Shared	100	0	No	No	No	No	5	6
228	6x36	7x56	Shared	100	100	No	No	Yes	No	8	7
229	6x44	6x48	Shared	100	100	Yes	No	Yes	Yes	9	8
230	6x47	7x45	Shared	100	100	No	Yes	No	No	8	9
231	6x48	7x41	Shared	100	100	Yes	Yes	No	No	8	7
232	6x50	7x37	Shared	100	100	No	No	Yes	Yes	9	5
233	6x51	6x52	Shared	100	100	Yes	Yes	Yes	Yes	7	7
234	6x51	7x34	Shared	100	100	Yes	Yes	No	No	7	3
235	6x51	7x38	Shared	100	100	Yes	Yes	No	No	7	6
236	6x51	Lig	Shared	100	100	Yes	Yes	Yes	Yes	7	0
237	6x52	Lig	Shared	100	100	Yes	Yes	Yes	Yes	7	0
238	6x54	7x34	Shared	100	100	No	No	No	No	5	3
239	6x54	7x37	Shared	100	100	No	No	Yes	Yes	5	5
240	6x58	7x30	Shared	100	100	No	No	No	No	4	4
241	6x61	E3	Shared	100	50	No	No	No	Yes	3	3
242	7x26	7x28	Shared	100	100	No	No	No	No	1	2
243	7x26	7x29	Shared	100	100	No	No	No	No	1	5
244	7x33	7x37	Shared	100	100	No	No	Yes	Yes	4	5
245	7x38	7x42	Shared	100	100	No	No	Yes	Yes	6	7
246	7x38	Lig	Shared	100	100	No	No	Yes	Yes	6	0
247	7x39	7x42	Shared	100	100	Yes	Yes	Yes	Yes	6	7
248	7x42	Lig	Shared	100	100	Yes	Yes	Yes	Yes	7	0
249	7x49	7x50	Shared	100	100	Yes	No	No	No	9	9
250	7x51	7x55	Shared	100	100	No	No	No	No	6	5
251	7x54	8x54	Shared	100	50	No	Yes	Yes	No	7	6
252	8x47	8x49	Shared	100	100	No	No	No	No	9	6
253	8x47	8x50	Shared	100	100	No	No	Yes	Yes	9	8
254	8x48	8x52	Shared	100	100	No	No	No	No	5	4
255	2x46	3x42	Shared	100	100	No	No	Yes	Yes	9	8
256	5x58	6x41	Shared	100	100	Yes	No	Yes	Yes	9	8
257	3x43	7x49	Shared	100	100	No	No	Yes	No	8	9
258	6x29	6x32	Shared	100	50	No	No	No	No	6	8
259	7x54	8x50	Shared	100	100	No	Yes	Yes	Yes	7	8
260	1x57	8x50	Shared	66.6667	50	No	No	Yes	Yes	7	8
261	1x54	2x48	Shared	50	100	No	No	No	No	6	6
262	1x53	2x47	Shared	77.7778	50	No	No	No	No	9	9
263	4x65	E2	Shared	66.6667	100	No	No	Yes	Yes	7	3
264	5x37	6x59	Shared	33.3333	100	No	No	No	No	4	5
265	2x42	3x45	Shared	50	100	Yes	Yes	No	No	8	7
266	3x56	I2x52	Shared	33.3333	100	No	No	No	No	6	5
267	5x48	6x56	Shared	50	100	No	No	No	No	5	5
268	3x44	5x50	Shared	72.2222	75	No	No	Yes	No	6	9
269	2x51	2x55	Shared	44.4444	100	No	No	No	No	7	4
270	E1x49	E2	Shared	33.3333	100	No	No	Yes	Yes	4	3
271	3x26	4x66	Shared	33.3333	75	No	No	No	No	6	5
272	3x56	I2x50	Shared	66.6667	0	No	No	No	No	6	8
273	6x47	7x40	Shared	33.3333	100	No	Yes	No	No	8	7
274	5x56	5x60	Shared	0	50	No	No	No	No	5	5
275	1x51	1x55	Shared	33.3333	25	No	No	No	No	3	4
276	3x34	4x54	Shared	33.3333	75	No	No	No	No	6	4
277	1x56	8x50	Shared	0	50	No	No	Yes	Yes	7	8
278	2x49	4x50	Shared	0	75	No	No	Yes	Yes	8	9
279	3x37	4x56	Shared	44.4444	100	No	No	No	No	7	6
280	1x41	1x45	Shared	33.3333	50	No	No	No	No	4	4
281	6x40	7x52	Shared	0	25	No	No	No	No	8	8
282	7x31	7x35	Shared	33.3333	100	No	No	No	No	2	4
283	5x41	6x59	Shared	33.3333	100	Yes	No	No	No	6	5
284	5x36	5x38	Shared	33.3333	100	Yes	No	No	No	5	3
285	3x48	5x53	Shared	16.6667	100	No	No	No	No	6	6
286	6x49	6x53	Shared	33.3333	50	No	No	No	No	6	6
287	2x63	E1x50	Shared	0	0	No	No	Yes	No	5	7
288	8x48	8x51	Shared	27.7778	100	No	No	No	No	5	9
289	2x57	2x58	Shared	16.6667	0	Yes	Yes	No	No	8	8
290	1x52	8x58	Shared	5.55556	0	No	No	No	No	6	6
291	6x49	6x50	Shared	0	100	No	No	No	No	6	9
292	5x41	6x60	Shared	33.3333	100	Yes	No	No	No	6	4
293	3x55	3x56	Shared	16.6667	100	No	No	No	No	6	6
294	8x55	8x56	Shared	33.3333	0	No	No	No	No	3	4
295	6x43	6x47	Shared	0	100	No	No	No	Yes	6	8
296	7x36	7x37	Shared	16.6667	25	No	No	Yes	Yes	4	5
297	4x47	4x51	Shared	0	0	No	No	No	No	2	4
298	4x39	I2x57	Shared	33.3333	100	Yes	No	No	No	4	6
299	4x48	4x52	Shared	16.6667	50	No	No	No	No	2	5
300	5x52	5x56	Shared	0	75	No	No	No	No	3	5
301	4x38	4x40	Shared	0	100	No	No	No	No	7	5
302	4x41	4x44	Shared	5.55556	50	No	Yes	No	No	6	3
303	4x51	4x52	Shared	0	25	No	No	No	No	4	5
304	6x24	6x27	Shared	0	50	No	No	Yes	No	0	5
305	4x63	4x67	Shared	0	0	No	No	No	No	5	6
306	1x50	2x51	5ht2_on	0	100	No	Yes	No	No	9	7
307	2x42	3x42	5ht2_on	0	100	Yes	Yes	Yes	Yes	8	8
308	2x50	7x50	5ht2_on	0	100	Yes	Yes	No	No	9	9
309	2x53	2x54	5ht2_on	0	100	No	Yes	No	No	7	6
310	2x60	3x28	5ht2_on	0	100	No	No	No	No	7	5
311	2x61	2x65	5ht2_on	0	100	No	No	No	No	6	5
312	2x66	E1x49	5ht2_on	0	100	No	No	No	No	4	4
313	3x23	E2	5ht2_on	0	100	No	No	Yes	Yes	1	3
314	3x28	3x29	5ht2_on	0	100	No	No	No	No	5	5
315	3x29	E2x50	5ht2_on	0	100	No	No	No	No	5	9
316	3x30	4x57	5ht2_on	0	100	No	Yes	No	No	6	7
317	3x30	4x61	5ht2_on	0	100	No	Yes	Yes	No	6	6
318	3x37	3x41	5ht2_on	0	100	No	No	No	No	7	6
319	3x40	6x48	5ht2_on	0	100	No	No	Yes	Yes	8	8
320	3x43	7x53	5ht2_on	0	100	No	No	No	Yes	8	9
321	3x46	3x50	5ht2_on	0	100	No	No	Yes	No	9	9
322	3x46	7x53	5ht2_on	0	100	No	No	No	Yes	9	9
323	3x47	5x54	5ht2_on	0	100	No	No	No	No	9	8
324	3x49	I2x53	5ht2_on	0	100	No	No	No	Yes	9	7
325	3x50	7x53	5ht2_on	0	100	Yes	No	No	Yes	9	9
326	3x51	5x57	5ht2_on	0	100	No	Yes	No	No	8	5
327	3x53	I2x53	5ht2_on	0	100	No	No	No	Yes	8	7
328	3x55	5x64	5ht2_on	0	100	No	No	No	No	6	6
329	I2x51	I2x55	5ht2_on	0	100	No	No	No	No	7	4
330	5x39	E2x52	5ht2_on	0	100	No	No	No	No	7	4
331	5x461	Lig	5ht2_on	0	100	No	No	Yes	Yes	6	0
332	5x47	5x51	5ht2_on	0	100	No	Yes	No	No	8	6
333	5x47	6x48	5ht2_on	0	100	No	Yes	Yes	Yes	8	8
334	5x54	6x44	5ht2_on	0	100	No	No	Yes	No	8	9
335	5x55	6x41	5ht2_on	0	100	No	No	Yes	Yes	5	8
336	5x62	6x34	5ht2_on	0	100	No	No	No	No	5	7
337	5x65	6x34	5ht2_on	0	100	No	Yes	No	No	8	7
338	6x40	7x53	5ht2_on	0	100	No	No	No	Yes	8	9
339	6x48	7x45	5ht2_on	0	100	Yes	Yes	No	No	8	9
340	7x49	7x53	5ht2_on	0	100	Yes	No	No	Yes	9	9
341	2x39	2x40	5ht2_on	0	100	No	No	No	No	8	9
342	2x62	2x66	5ht2_on	0	100	No	No	No	No	4	4
343	3x27	3x30	5ht2_on	0	100	No	No	No	Yes	4	6
344	I2x53	I2x57	5ht2_on	0	100	No	Yes	No	No	7	6
345	4x43	4x47	5ht2_on	0	100	No	No	No	No	4	2
346	5x38	5x39	5ht2_on	0	100	No	No	No	No	3	7
347	5x65	5x66	5ht2_on	0	100	No	Yes	No	No	8	6
348	5x66	6x34	5ht2_on	0	100	No	No	No	No	6	7
349	2x37	2x41	5ht2_on	0	100	No	No	No	No	7	4
350	3x49	4x41	5ht2_on	0	100	No	No	No	Yes	9	6
351	4x41	I2x56	5ht2_on	0	100	No	Yes	No	No	6	4
352	4x38	4x39	5ht2_on	0	100	No	No	Yes	No	7	4
353	5x36	5x37	5ht2_on	0	100	Yes	No	No	No	5	4
354	5x44	Lig	5ht2_on	0	100	No	No	Yes	Yes	6	0
355	5x67	5x70	5ht2_on	0	100	No	No	No	No	5	0
356	6x58	7x27	5ht2_on	0	100	No	No	No	No	4	3
357	E3	E3	5ht2_on	0	100	No	Yes	No	Yes	3	3
358	7x27	E3	5ht2_on	0	100	No	No	No	Yes	3	3
359	7x28	7x31	5ht2_on	0	100	No	No	No	No	2	2
360	7x28	7x32	5ht2_on	0	100	No	No	No	No	2	1
361	7x31	7x32	5ht2_on	0	100	No	No	No	No	2	1
362	1x37	1x39	5ht2_on	0	50	No	No	No	Yes	4	6
363	6x47	7x43	5ht2_on	0	75	No	Yes	No	No	8	4
364	1x47	1x51	5ht2_on	0	75	No	No	No	No	5	3
365	6x27	6x31	5ht2_on	0	50	Yes	No	No	No	5	5
366	2x38	I1x51	5ht2_on	0	50	No	No	No	No	5	7
367	I1x51	I2x57	5ht2_on	0	50	No	No	No	No	7	6
368	2x64	7x35	5ht2_on	0	50	No	No	No	No	5	4
369	1x54	2x47	5ht2_on	0	75	No	No	No	No	6	9
370	6x24	6x26	5ht2_on	0	50	No	No	No	No	0	5
371	5x40	6x59	5ht2_on	0	50	No	No	No	No	6	5
372	8x52	8x56	5ht2_on	0	50	No	No	No	No	4	4
373	7x43	7x48	5ht2_on	0	50	No	No	No	No	4	6
374	3x48	5x57	5ht2_on	0	25	No	No	No	No	6	5
375	5x42	5x43	5ht2_on	0	25	No	No	No	No	4	6
376	5x38	5x42	5ht2_on	0	50	No	No	No	No	3	4
377	8x47	8x48	5ht2_on	0	50	No	No	No	No	9	5
378	2x551	3x31	5ht2_on	0	50	No	No	No	No	5	5
379	1x48	1x49	5ht2_on	0	0	No	No	No	No	4	8
380	1x53	7x54	5ht2_on	0	25	No	No	No	Yes	9	7
381	1x58	1x59	5ht2_on	0	25	No	No	No	No	1	5
382	5x69	6x30	5ht2_on	0	50	No	No	Yes	Yes	5	8
383	1x60	8x53	5ht2_on	0	50	Yes	No	No	No	6	7
384	5x67	5x71	5ht2_on	0	50	No	No	No	No	5	0
385	2x43	7x54	5ht2_on	0	50	No	No	No	Yes	8	7
386	4x44	4x48	5ht2_on	0	50	No	No	No	No	3	2
387	6x35	6x39	5ht2_on	0	25	No	No	No	No	7	6
388	6x53	6x57	5ht2_on	0	25	No	No	No	No	6	4
389	6x32	6x35	5ht2_on	0	50	No	No	No	No	8	7
390	1x60	I1x49	5ht2_on	0	50	Yes	No	No	No	6	6
391	3x21	3x24	5ht2_on	0	50	No	No	No	No	7	5
392	6x36	6x40	5ht2_on	0	0	No	No	No	No	8	8
393	6x45	6x49	5ht2_on	0	50	No	No	No	No	6	6
394	5x65	6x33	5ht2_on	0	0	No	Yes	No	No	8	8
395	6x32	7x56	5ht2_on	0	50	No	No	Yes	No	8	7
396	2x67	E1	5ht2_on	0	50	No	No	No	No	5	3
397	6x57	7x30	5ht2_on	0	25	No	No	No	No	4	4
398	3x23	4x66	5ht2_on	0	50	No	No	No	No	1	5
399	4x54	4x55	5ht2_on	0	0	No	No	No	No	4	4
400	5x65	6x30	5ht2_on	0	25	No	Yes	Yes	Yes	8	8
401	I2x54	I2x55	5ht2_on	0	25	No	No	No	No	6	4
402	1x49	1x52	5ht2_on	0	25	No	No	No	No	8	6
403	4x60	4x64	5ht2_on	0	25	No	No	No	No	7	4
404	6x46	6x47	5ht2_on	0	25	No	No	No	Yes	5	8
405	6x41	6x42	5ht2_on	0	25	Yes	Yes	No	No	8	5
406	3x52	I2x53	5ht2_on	0	0	No	No	No	Yes	5	7
407	6x27	6x30	5ht2_on	0	25	Yes	No	Yes	Yes	5	8
408	5x68	5x71	5ht2_on	0	25	No	No	No	No	7	0
409	7x55	8x51	5ht2_on	0	0	No	No	No	No	5	9
410	1x40	1x41	5ht2_on	0	0	No	No	No	No	3	4
411	1x40	1x43	5ht2_on	0	0	No	No	No	No	3	6
412	I1x48	I1x49	5ht2_on	0	0	No	No	No	No	6	6
413	5x45	5x46	5ht2_on	0	0	No	No	No	No	4	4
414	5x63	5x64	5ht2_on	0	0	No	No	No	No	4	6
415	6x28	6x31	5ht2_on	0	0	No	No	No	No	6	5
416	4x64	4x67	5ht2_on	0	0	No	No	No	No	4	6
417	2x38	4x42	5ht2_on	0	0	No	No	No	No	5	7
418	5x55	5x59	5ht2_on	0	0	No	No	No	No	5	1
419	1x38	1x39	5ht2_on	0	0	No	No	No	Yes	4	6
420	1x43	1x44	5ht2_on	0	0	No	No	No	No	6	4
421	1x41	1x44	5ht2_on	0	0	No	No	No	No	4	4

Orange: nodes, hubs and links specific of 5ht2_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of 5ht2_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	5ht2_off Avg Int. Strength	5ht2_on Avg Int. Strength	5ht2_off Num Of Links	5ht2_on Num Of Links	ConSurf
1	1x35	5ht2_off	0	0	4	0	3
2	1x60	5ht2_off	16.6667	0	4	3	6
3	I1x50	5ht2_off	66.6667	0	4	3	8
4	2x56	5ht2_off	0	0	4	3	8
5	E1x50	5ht2_off	100	0	7	3	7
6	3x50	5ht2_off	33.3333	0	6	3	9
7	4x39	5ht2_off	0	0	4	2	4
8	4x61	5ht2_off	0	50	4	3	6
9	5x36	5ht2_off	33.3333	0	4	3	5
10	5x41	5ht2_off	0	0	4	2	6
11	5x50	5ht2_off	50	0	4	3	9
12	5x58	5ht2_off	0	0	4	3	9
13	6x27	5ht2_off	0	0	4	3	5
14	6x44	5ht2_off	94.4445	0	6	2	9
15	7x49	5ht2_off	16.6667	0	4	3	9
16	7x56	5ht2_off	33.3333	0	4	2	7
17	8x54	5ht2_off	66.6667	0	4	2	6
18	8x57	5ht2_off	55.5556	0	5	2	4
19	CT	5ht2_off	38.8889	0	8	0	5
20	NT	5ht2_off	33.3333	0	5	0	0
21	2x42	Shared	33.3333	50	4	4	8
22	2x50	Shared	66.6667	50	4	5	9
23	2x57	Shared	100	25	7	4	8
24	3x35	Shared	66.6667	100	5	4	7
25	3x42	Shared	66.6667	100	4	5	8
26	4x50	Shared	66.6667	50	5	4	9
27	E2	Shared	100	100	14	10	3
28	6x30	Shared	0	0	4	4	8
29	6x41	Shared	88.8889	0	6	4	8
30	6x48	Shared	100	100	5	5	8
31	6x51	Shared	100	25	6	4	7
32	6x52	Shared	94.4445	75	5	4	7
33	7x37	Shared	0	0	4	4	5
34	7x39	Shared	83.3333	50	5	4	6
35	7x42	Shared	100	100	6	5	7
36	8x50	Shared	100	50	8	6	8
37	Lig	Shared	100	100	11	9	0
38	1x39	5ht2_on	0	0	2	4	6
39	1x50	5ht2_on	0	25	3	4	9
40	2x53	5ht2_on	0	50	3	4	7
41	3x30	5ht2_on	0	0	1	4	6
42	3x51	5ht2_on	0	50	3	4	8
43	I2x53	5ht2_on	0	0	1	4	7
44	4x41	5ht2_on	0	0	3	4	6
45	5x47	5ht2_on	50	25	3	4	8
46	5x65	5ht2_on	0	0	3	5	8
47	6x47	5ht2_on	0	0	3	5	8
48	7x53	5ht2_on	50	75	2	5	9
49	7x54	5ht2_on	0	0	3	4	7
50	E3	5ht2_on	22.2222	50	2	4	3

Orange: nodes, hubs and links specific of 5ht2_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of 5ht2_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	5ht2_off Recurrence	5ht2_on Recurrence	5ht2_off Hub1?	5ht2_on Hub1?	5ht2_off Hub2?	5ht2_on Hub2?	ConSurf1	ConSurf2
1	1x39	7x39	5ht2_off	10.7242	4.45629	No	Yes	Yes	Yes	6	6
2	1x53	8x54	5ht2_off	90.9332	0	No	No	Yes	No	9	6
3	8x50	8x54	5ht2_off	78.6979	0	Yes	Yes	Yes	No	8	6
4	8x50	I1x50	5ht2_off	54.3899	6.17982	Yes	Yes	Yes	No	8	8
5	1x60	I1x50	5ht2_off	49.2661	5.11372	Yes	No	Yes	No	6	8
6	1x60	8x57	5ht2_off	20.3921	0	Yes	No	Yes	No	6	4
7	1x55	8x57	5ht2_off	14.9434	3.58209	No	No	Yes	No	4	4
8	1x51	1x55	5ht2_off	12.8636	4.91116	No	No	No	No	3	4
9	6x48	Lig	5ht2_off	67.1343	0	Yes	Yes	Yes	Yes	8	0
10	6x44	7x49	5ht2_off	33.4615	0	Yes	No	Yes	No	9	9
11	1x57	8x50	5ht2_off	10.7025	2.64392	No	No	Yes	Yes	7	8
12	1x60	CT	5ht2_off	22.9973	0	Yes	No	Yes	No	6	5
13	CT	I1x48	5ht2_off	18.7618	0	Yes	No	No	No	5	6
14	I1x48	I1x51	5ht2_off	16.7253	0	No	No	No	No	6	7
15	2x41	I1x51	5ht2_off	14.6509	2.69012	No	No	No	No	4	7
16	3x35	4x50	5ht2_off	17.2182	0	Yes	Yes	Yes	Yes	7	9
17	2x45	4x46	5ht2_off	12.1378	1.34684	No	No	No	No	9	8
18	2x42	4x46	5ht2_off	11.7695	0	Yes	Yes	No	No	8	8
19	3x43	6x44	5ht2_off	46.4063	0	No	No	Yes	No	8	9
20	3x43	6x41	5ht2_off	65.2548	0	No	No	Yes	Yes	8	8
21	3x46	6x41	5ht2_off	17.1857	0	No	No	Yes	Yes	9	8
22	3x39	6x44	5ht2_off	31.008	0	No	No	Yes	No	9	9
23	2x56	3x28	5ht2_off	20.2134	0	Yes	No	No	No	8	5
24	2x64	7x39	5ht2_off	18.8702	8.43994	No	No	Yes	Yes	5	6
25	3x28	E1x50	5ht2_off	16.9149	0	No	No	Yes	No	5	7
26	E1x50	E1x51	5ht2_off	13.4864	0	Yes	No	No	No	7	3
27	2x66	E1x51	5ht2_off	10.6267	1.15849	No	No	No	No	4	3
28	E2x51	Lig	5ht2_off	30.293	0	No	No	Yes	Yes	4	0
29	E2	E2x51	5ht2_off	29.0364	1.37527	Yes	Yes	No	No	3	4
30	3x33	Lig	5ht2_off	20.9933	1.39303	No	No	Yes	Yes	6	0
31	3x33	4x61	5ht2_off	16.0483	0	No	No	Yes	No	6	6
32	3x38	4x50	5ht2_off	12.0836	2.69012	No	No	Yes	Yes	8	9
33	3x38	4x53	5ht2_off	10.0959	1.34684	No	No	No	No	8	8
34	3x40	6x44	5ht2_off	21.3454	0	No	No	Yes	No	8	9
35	3x40	5x50	5ht2_off	19.5959	4.17555	No	No	Yes	No	8	9
36	6x37	6x41	5ht2_off	43.6278	0	No	No	Yes	Yes	8	8
37	3x50	6x37	5ht2_off	42.3225	1.18337	Yes	No	No	No	9	8
38	3x50	6x30	5ht2_off	36.9225	0	Yes	No	Yes	Yes	9	8
39	3x54	6x30	5ht2_off	23.0082	0	No	No	Yes	Yes	9	8
40	3x54	5x65	5ht2_off	20.4246	1.17982	No	No	No	Yes	9	8
41	5x61	5x65	5ht2_off	16.33	0	No	No	No	Yes	9	8
42	3x51	5x61	5ht2_off	14.8459	1.39659	No	Yes	No	No	8	9
43	2x42	3x46	5ht2_off	15.9833	2.91756	Yes	Yes	No	No	8	9
44	2x41	4x39	5ht2_off	10.8216	0	No	No	Yes	No	4	4
45	5x47	Lig	5ht2_off	19.0164	0	No	Yes	Yes	Yes	8	0
46	5x47	5x48	5ht2_off	27.899	5.52239	No	Yes	No	No	8	5
47	5x68	6x30	5ht2_off	13.0423	4.69083	No	No	Yes	Yes	7	8
48	5x68	6x27	5ht2_off	11.8128	0	No	No	Yes	No	7	5
49	6x40	7x49	5ht2_off	11.5583	0	No	No	Yes	No	8	9
50	1x35	2x64	5ht2_off	11.6937	0	Yes	No	No	No	3	5
51	5x48	6x56	5ht2_off	21.692	1.36461	No	No	No	No	5	5
52	5x41	6x56	5ht2_off	18.9406	0	Yes	No	No	No	6	5
53	2x57	7x42	5ht2_off	11.997	0	Yes	Yes	Yes	Yes	8	7
54	1x50	7x50	5ht2_off	45.0848	2.17129	No	Yes	No	No	9	9
55	3x43	7x49	5ht2_off	19.7205	1.17271	No	No	Yes	No	8	9
56	2x50	3x39	5ht2_off	30.3851	1.34684	Yes	Yes	No	No	9	9
57	E1x50	E2	5ht2_off	17.9873	0	Yes	No	Yes	Yes	7	3
58	6x48	6x51	5ht2_off	19.2222	0	Yes	Yes	Yes	Yes	8	7
59	6x48	6x52	5ht2_off	13.1452	0	Yes	Yes	Yes	Yes	8	7
60	7x39	7x42	Shared	30.4501	34.9431	Yes	Yes	Yes	Yes	6	7
61	2x56	7x42	Shared	23.6906	62.1997	Yes	No	Yes	Yes	8	7
62	2x53	2x56	Shared	35.9963	100	No	Yes	Yes	No	7	8
63	2x53	7x46	Shared	23.6852	94.6517	No	Yes	No	No	7	9
64	2x50	7x46	Shared	23.474	93.9765	Yes	Yes	No	No	9	9
65	1x50	2x50	Shared	53.2416	44.6233	No	Yes	Yes	Yes	9	9
66	1x50	2x47	Shared	94.2371	37.2672	No	Yes	No	No	9	9
67	1x53	2x47	Shared	92.6231	33.8451	No	No	No	No	9	9
68	7x42	Lig	Shared	28.7277	53.0775	Yes	Yes	Yes	Yes	7	0
69	6x44	6x48	Shared	100	48.7775	Yes	No	Yes	Yes	9	8
70	7x49	7x50	Shared	46.3413	17.1393	Yes	No	No	No	9	9
71	2x53	3x35	Shared	17.4999	27.4769	No	Yes	Yes	Yes	7	7
72	2x42	4x45	Shared	13.7735	30.5686	Yes	Yes	No	No	8	6
73	2x46	2x50	Shared	10.6483	42.2566	No	No	Yes	Yes	9	9
74	4x41	4x45	Shared	10.3288	13.7385	No	Yes	No	No	6	6
75	4x61	5x39	Shared	10.605	15.1919	Yes	No	No	No	6	7
76	6x51	Lig	Shared	12.4898	17.58	Yes	Yes	Yes	Yes	7	0
77	5x58	6x41	Shared	10.5833	23.6674	Yes	No	Yes	Yes	9	8
78	6x51	7x34	Shared	28.0886	29.1578	Yes	Yes	No	No	7	3
79	6x54	7x34	Shared	26.5775	27.5764	No	No	No	No	5	3
80	6x54	7x37	Shared	20.078	25.6326	No	No	Yes	Yes	5	5
81	5x47	6x52	Shared	11.9645	69.7761	No	Yes	Yes	Yes	8	7
82	2x53	2x54	5ht2_on	0	15.7321	No	Yes	No	No	7	6
83	2x54	2x57	5ht2_on	1.65195	14.4598	No	No	Yes	Yes	6	8
84	1x50	2x51	5ht2_on	0	10.1421	No	Yes	No	No	9	7
85	2x50	7x50	5ht2_on	0	16.1087	Yes	Yes	No	No	9	9
86	1x53	7x54	5ht2_on	0	32.6617	No	No	No	Yes	9	7
87	7x54	8x50	5ht2_on	0.926177	24.9147	No	Yes	Yes	Yes	7	8
88	2x46	3x42	5ht2_on	9.33218	41.2154	No	No	Yes	Yes	9	8
89	2x42	3x42	5ht2_on	0	32.9993	Yes	Yes	Yes	Yes	8	8
90	3x49	4x45	5ht2_on	1.72778	15.6574	No	No	No	No	9	6
91	3x49	I2x53	5ht2_on	0	15.0888	No	No	No	Yes	9	7
92	I2x53	I2x57	5ht2_on	0	11.4712	No	Yes	No	No	7	6
93	2x60	7x39	5ht2_on	1.44614	25.2452	No	No	Yes	Yes	7	6
94	2x60	3x28	5ht2_on	0	24.5487	No	No	No	No	7	5
95	3x28	3x29	5ht2_on	0	23.2409	No	No	No	No	5	5
96	3x29	E2x50	5ht2_on	0	22.5267	No	No	No	No	5	9
97	3x25	E2x50	5ht2_on	0.76369	18.479	No	No	No	No	9	9
98	3x25	E2	5ht2_on	1.55446	17.7292	No	No	Yes	Yes	9	3
99	3x34	3x35	5ht2_on	6.74322	23.3831	No	No	Yes	Yes	6	7
100	3x34	4x57	5ht2_on	6.55906	20.3127	No	No	No	No	6	7
101	3x30	4x57	5ht2_on	0	19.2999	No	Yes	No	No	6	7
102	3x30	4x61	5ht2_on	0	16.1194	No	Yes	Yes	No	6	6
103	6x52	Lig	5ht2_on	1.40281	66.9119	Yes	Yes	Yes	Yes	7	0
104	5x47	6x48	5ht2_on	0	63.7527	No	Yes	Yes	Yes	8	8
105	7x49	7x53	5ht2_on	0	14.936	Yes	No	No	Yes	9	9
106	5x54	6x44	5ht2_on	0	47.6546	No	No	Yes	No	8	9
107	3x47	5x54	5ht2_on	0	20.2523	No	No	No	No	9	8
108	3x47	5x57	5ht2_on	1.58696	18.9517	No	No	No	No	9	5
109	3x51	5x57	5ht2_on	0	15.0071	No	Yes	No	No	8	5
110	5x54	6x41	5ht2_on	9.38634	28.7207	No	No	Yes	Yes	8	8
111	5x58	5x62	5ht2_on	1.58696	21.0874	Yes	No	No	No	9	5
112	5x62	6x34	5ht2_on	0	19.7939	No	No	No	No	5	7
113	5x65	6x34	5ht2_on	0	17.3383	No	Yes	No	No	8	7
114	5x36	E2	5ht2_on	5.78454	12.3276	Yes	No	Yes	Yes	5	3
115	5x36	5x38	5ht2_on	2.1665	11.8586	Yes	No	No	No	5	3
116	5x38	5x39	5ht2_on	0	13.575	No	No	No	No	3	7
117	6x40	7x53	5ht2_on	0	11.7235	No	No	No	Yes	8	9
118	6x48	7x45	5ht2_on	0	10.9986	Yes	Yes	No	No	8	9
119	7x38	7x42	5ht2_on	4.92878	10.6361	No	No	Yes	Yes	6	7
120	6x51	7x38	5ht2_on	5.43249	10.2665	Yes	Yes	No	No	7	6
121	6x50	7x37	5ht2_on	6.78655	19.7512	No	No	Yes	Yes	9	5
122	6x49	6x50	5ht2_on	4.53339	17.7754	No	No	No	No	6	9
123	6x49	6x53	5ht2_on	2.2694	13.8024	No	No	No	No	6	6
124	6x53	6x57	5ht2_on	0	11.8053	No	No	No	No	6	4
125	8x47	8x50	5ht2_on	6.11493	11.8621	No	No	Yes	Yes	9	8
126	5x65	6x30	5ht2_on	0	13.5785	No	Yes	Yes	Yes	8	8
127	2x56	3x32	5ht2_on	5.37832	38.1699	Yes	No	No	No	8	8
128	3x32	Lig	5ht2_on	5.6383	37.9815	No	No	Yes	Yes	8	0

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
2x56	3x32	Shared	7.05778	10.225	1	1	2	1
2x56	7x42	Shared	3.71667	4.1025	1	1	2	1
2x57	7x39	5ht2_off	5.75056	0	1	0	2	2
2x57	7x42	5ht2_off	6.65056	0	1	0	2	1
3x32	7x42	Shared	7.98445	8.905	1	1	1	1
3x32	Lig	Shared	16.8822	12.7025	1	1	1	0
3x33	4x57	5ht2_off	3.55389	0	0	0	1	2
3x33	4x61	5ht2_off	3.60667	0	0	0	1	2
3x33	Lig	Shared	8.875	12.3	0	0	1	0
3x36	Lig	Shared	9.995	11.8325	0	0	1	0
3x37	5x461	Shared	4.86167	2.84	0	0	2	1
3x40	6x44	5ht2_off	6.14167	0	0	0	2	2
E2	E2	Shared	28.4083	22.17	1	3	2	2
E2	E2x51	Shared	6.59389	7.7575	1	3	2	1
5x44	6x52	Shared	4.91389	3.9625	0	1	1	1
5x47	5x48	Shared	6.37278	7.2375	1	0	1	2
5x47	6x52	Shared	24.8261	19.8275	1	0	1	1
6x44	6x48	Shared	9.24222	6.5125	1	0	2	1
6x44	7x45	5ht2_off	7.92556	0	1	0	2	2
6x48	6x51	5ht2_off	6.29389	0	1	0	1	1
6x48	6x52	5ht2_off	5.51222	0	1	0	1	1
6x48	7x41	Shared	12.435	4.575	1	0	1	2
6x48	Lig	5ht2_off	10.5694	0	1	0	1	0
6x51	6x52	Shared	8.51333	6.165	1	1	1	1
6x51	6x55	5ht2_off	7.04833	0	1	1	1	2
6x51	7x34	Shared	4.19556	2.7425	1	1	1	2
6x51	7x38	Shared	4.87611	3.935	1	1	1	1
6x51	Lig	Shared	11.7239	9.38	1	1	1	0
6x52	Lig	Shared	12.1417	10.66	1	1	1	0
6x55	7x34	5ht2_off	4.88278	0	1	0	2	2
7x38	7x42	Shared	6.51944	5.365	1	1	1	1
7x38	Lig	Shared	7.17722	2.7225	1	1	1	0
7x39	7x42	Shared	10.3444	6.755	1	0	2	1
7x42	Lig	Shared	3.98333	2.8875	1	1	1	0
5x47	Lig	5ht2_off	3.81111	0	1	0	1	0
E2x51	Lig	5ht2_off	3.665	0	1	0	1	0
5x43	Lig	5ht2_off	1.28167	0	0	0	1	0
3x40	6x48	5ht2_on	0	4.11	0	0	2	1
5x461	Lig	5ht2_on	0	3.885	0	0	1	0
5x47	5x51	5ht2_on	0	2.7425	1	0	1	2
5x47	6x48	5ht2_on	0	3.76	1	0	1	1
6x48	7x45	5ht2_on	0	6.4075	1	0	1	2
5x44	Lig	5ht2_on	0	3.9325	0	1	1	0
5x42	5x43	5ht2_on	0	2.2025	0	0	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	5ht2_off	5ht2a_off 5ht2b_off 5ht2c_off
	5ht2_on	5ht2a_on 5ht2c_on

Network Difference
Value	5ht2_off	5ht2_on
I_min	3.41222	2.6225
Number of Linked Nodes	276	261
Number of Specific Nodes	17 (6.16%)	2 (0.77%)
Number of Shared Nodes	259 (93.84%)	259 (99.23%)
Number of Links	305	280
Number of Specific Links	141 (46.23%)	116 (41.43%)
Number of Shared Links	164 (53.77%)	164 (58.57%)
Number of Hubs	37	30
Number of Specific Hubs	20 (54.05%)	13 (43.33%)
Number of Shared Hubs	17 (45.95%)	17 (56.67%)
Average % Shared Neighbours (Jaccard)	41.80
Average % Shared Neighbours (Otsuka)	51.54
Average % Shared Neighbours (Overlap Coefficient)	61.86
Average % Shared Cliques (k3-6)	56.25
Graphlets Similarity	0.575772

Paths Difference
Value	5ht2_off	5ht2_on
Number Of Nodes in MetaPath	76	67
Specific Nodes in MetaPath	39 (51.32%)	30 (44.78%)
Shared Nodes in MetaPath	259 (93.84%)	259 (93.84%)
Number Of Links MetaPath	81	69
Specific Links in MetaPath	59 (72.84%)	47 (68.12%)
Shared Links in MetaPath	164 (53.77%)	164 (53.77%)
Number of Shortest Paths	47359	48777
Length Of Smallest Path	3	3
Average Path Length	12.4574	15.6174
Length of Longest Path	29	32
Minimum Path Strength	0.240556	0.3675
Average Path Strength	5.60327	5.48222
Maximum Path Strength	16.6697	15.2437
Minimum Path Correlation	0.7	0.7
Average Path Correlation	0.918099	0.909765
Maximum Path Correlation	0.99	0.9875
Minimum % Of Corr. Nodes	4	3.57143
Average % Of Corr. Nodes	48.3939	39.6517
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	44.0132	40.9229
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

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