psnGPCR

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Orange: nodes, hubs and links specific of 5ht2_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of 5ht2_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	5ht2_off Int. Strength	5ht2_on Int. Strength	5ht2_off Hub1?	5ht2_on Hub1?	5ht2_off Hub2?	5ht2_on Hub2?	ConSurf1	ConSurf2
1	1x39	2x61	5ht2_off	5.49533	0	No	No	No	No	6	6
2	1x39	7x39	5ht2_off	15.9033	0	No	No	Yes	Yes	6	6
3	1x46	2x57	5ht2_off	5.01933	0	No	No	Yes	Yes	7	8
4	1x50	2x47	5ht2_off	3.64667	0	Yes	Yes	No	No	9	9
5	1x53	7x53	5ht2_off	3.61867	0	No	No	Yes	Yes	9	9
6	1x53	8x54	5ht2_off	3.668	0	No	No	Yes	No	9	6
7	1x55	8x57	5ht2_off	5.88733	0	No	No	Yes	No	4	4
8	1x59	8x57	5ht2_off	6.92067	0	No	No	Yes	No	5	4
9	1x60	I1x50	5ht2_off	5.214	0	No	No	Yes	No	6	8
10	2x40	I1x50	5ht2_off	5.95	0	No	No	Yes	No	9	8
11	2x41	4x43	5ht2_off	5.70933	0	Yes	No	No	No	4	4
12	2x42	3x46	5ht2_off	5.69533	0	Yes	No	No	No	8	9
13	2x42	4x46	5ht2_off	3.93733	0	Yes	No	No	No	8	8
14	2x43	7x53	5ht2_off	7.81267	0	No	No	Yes	Yes	8	9
15	2x46	3x39	5ht2_off	3.474	0	No	No	No	No	9	9
16	2x64	E1	5ht2_off	6.20467	0	No	No	No	No	5	3
17	2x66	E1x51	5ht2_off	10.4587	0	No	No	No	No	4	3
18	7x35	E1	5ht2_off	12.716	0	No	No	No	No	4	3
19	E1x50	E2	5ht2_off	3.874	0	Yes	Yes	Yes	Yes	7	3
20	3x24	E1x52	5ht2_off	5.26067	0	Yes	No	No	Yes	5	5
21	3x25	E2	5ht2_off	11.452	0	No	No	Yes	Yes	9	3
22	3x26	E2	5ht2_off	3.68733	0	No	No	Yes	Yes	6	3
23	3x33	4x61	5ht2_off	3.60667	0	No	No	No	No	6	6
24	3x34	4x57	5ht2_off	4.854	0	No	No	No	No	6	7
25	3x35	4x50	5ht2_off	3.81	0	Yes	Yes	Yes	Yes	7	9
26	3x37	Lig	5ht2_off	3.838	0	No	No	Yes	Yes	7	0
27	3x39	6x44	5ht2_off	5.48333	0	No	No	Yes	No	9	9
28	3x43	6x44	5ht2_off	7.632	0	No	No	Yes	No	8	9
29	I2x55	I2x56	5ht2_off	4.41733	0	No	No	No	No	4	4
30	4x41	4x45	5ht2_off	7.97	0	No	No	No	No	6	6
31	4x60	5x39	5ht2_off	4.33267	0	No	No	No	No	7	7
32	4x65	E2	5ht2_off	4.256	0	No	No	Yes	Yes	7	3
33	4x68	E2	5ht2_off	9.356	0	No	No	Yes	Yes	4	3
34	5x40	E2x52	5ht2_off	3.62533	0	No	No	No	No	6	4
35	5x36	5x39	5ht2_off	6.76467	0	Yes	No	No	No	5	7
36	6x25	6x29	5ht2_off	8.184	0	No	No	No	No	5	6
37	6x40	7x49	5ht2_off	4.532	0	No	No	No	No	8	9
38	6x44	6x48	5ht2_off	8.75333	0	Yes	No	Yes	No	9	8
39	6x44	7x45	5ht2_off	7.75733	0	Yes	No	No	No	9	9
40	6x48	6x51	5ht2_off	6.68267	0	Yes	No	Yes	Yes	8	7
41	6x48	Lig	5ht2_off	10.186	0	Yes	No	Yes	Yes	8	0
42	6x51	6x55	5ht2_off	6.524	0	Yes	Yes	No	No	7	7
43	6x52	Lig	5ht2_off	11.9027	0	Yes	Yes	Yes	Yes	7	0
44	6x55	7x34	5ht2_off	4.94333	0	No	No	No	No	7	3
45	7x33	7x37	5ht2_off	6.74	0	No	No	Yes	No	4	5
46	7x42	Lig	5ht2_off	4.136	0	Yes	Yes	Yes	Yes	7	0
47	7x53	8x50	5ht2_off	5.89	0	Yes	Yes	Yes	Yes	9	8
48	7x54	8x54	5ht2_off	6.13867	0	No	No	Yes	No	7	6
49	8x47	8x50	5ht2_off	7.78133	0	No	No	Yes	Yes	9	8
50	8x48	8x52	5ht2_off	6.49067	0	No	No	No	No	5	4
51	8x50	8x54	5ht2_off	5.00733	0	Yes	Yes	Yes	No	8	6
52	8x53	8x57	5ht2_off	5.06867	0	No	No	Yes	No	7	4
53	8x57	CT	5ht2_off	3.678	0	Yes	No	No	No	4	3
54	8x60	CT	5ht2_off	3.724	0	No	No	No	No	8	3
55	E2x51	Lig	5ht2_off	5.006	0	No	No	Yes	Yes	4	0
56	5x47	Lig	5ht2_off	3.57533	0	No	Yes	Yes	Yes	8	0
57	1x34	1x35	5ht2_off	4.748	0	No	No	Yes	No	4	3
58	1x60	I1x49	5ht2_off	7.02	0	No	No	No	No	6	6
59	I1x48	I1x49	5ht2_off	4.78933	0	No	No	No	No	6	6
60	3x43	6x41	5ht2_off	8.44533	0	No	No	Yes	No	8	8
61	3x47	6x41	5ht2_off	5.10733	0	No	No	Yes	No	9	8
62	3x50	6x30	5ht2_off	4.26333	0	Yes	No	Yes	No	9	8
63	6x37	6x41	5ht2_off	7.064	0	No	No	Yes	No	8	8
64	NT	NT	5ht2_off	23.1567	0	Yes	No	Yes	No	0	0
65	E1	NT	5ht2_off	4.67333	0	No	No	Yes	No	3	0
66	1x33	NT	5ht2_off	8.40333	0	No	No	Yes	No	5	0
67	1x32	1x35	5ht2_off	4.40333	0	No	No	Yes	No	6	3
68	4x64	5x36	5ht2_off	3.83	0	No	No	Yes	No	4	5
69	6x35	6x39	5ht2_off	3.87667	0	No	No	No	No	7	6
70	7x31	7x35	5ht2_off	5.16333	0	No	No	No	No	2	4
71	2x66	NT	5ht2_off	3.79333	0	No	No	Yes	No	4	0
72	2x67	NT	5ht2_off	6.52667	0	No	No	Yes	No	5	0
73	7x49	7x53	5ht2_off	3.40933	0	No	No	Yes	Yes	9	9
74	2x51	2x55	5ht2_off	3.38467	0	No	No	No	No	7	4
75	3x28	3x29	5ht2_off	3.38467	0	Yes	No	No	No	5	5
76	1x52	8x57	5ht2_off	3.36267	0	No	No	Yes	No	6	4
77	7x55	7x56	5ht2_off	3.328	0	No	No	Yes	No	5	7
78	1x54	2x48	5ht2_off	3.27933	0	No	No	No	No	6	6
79	6x39	7x56	5ht2_off	3.264	0	No	No	Yes	No	6	7
80	5x37	6x59	5ht2_off	3.24267	0	No	No	No	No	4	5
81	3x44	5x50	5ht2_off	3.14067	0	No	No	Yes	No	6	9
82	3x26	4x66	5ht2_off	3.13533	0	No	No	No	No	6	5
83	1x60	8x56	5ht2_off	3.026	0	No	No	No	No	6	4
84	8x59	CT	5ht2_off	2.90133	0	No	No	No	No	4	3
85	4x59	4x63	5ht2_off	2.87533	0	No	No	No	No	4	5
86	2x41	2x44	5ht2_off	2.87333	0	Yes	No	Yes	No	4	5
87	3x50	6x34	5ht2_off	2.87133	0	Yes	No	No	No	9	7
88	3x50	6x33	5ht2_off	2.86	0	Yes	No	No	No	9	8
89	3x56	I2x51	5ht2_off	2.83267	0	No	No	No	No	6	7
90	4x41	4x44	5ht2_off	2.766	0	No	No	No	No	6	3
91	7x29	7x33	5ht2_off	2.74067	0	No	No	No	No	5	4
92	1x49	7x50	5ht2_off	2.70667	0	No	No	No	No	8	9
93	6x54	7x30	5ht2_off	2.696	0	No	No	No	No	5	4
94	4x38	4x41	5ht2_off	2.67533	0	No	No	No	No	7	6
95	5x54	6x45	5ht2_off	2.66067	0	No	No	No	No	8	6
96	5x69	6x27	5ht2_off	2.59533	0	No	No	No	No	5	5
97	3x51	5x57	5ht2_off	2.58	0	Yes	No	No	No	8	5
98	5x36	5x38	5ht2_off	2.51467	0	Yes	No	No	No	5	3
99	5x62	6x31	5ht2_off	2.50667	0	No	No	No	No	5	5
100	1x41	1x45	5ht2_off	2.45	0	No	No	No	No	4	4
101	2x39	3x50	5ht2_off	2.41533	0	No	No	Yes	No	8	9
102	2x62	E1x51	5ht2_off	2.29667	0	No	No	No	No	4	3
103	5x41	6x59	5ht2_off	2.28467	0	No	No	No	No	6	5
104	2x57	2x58	5ht2_off	2.23667	0	Yes	Yes	No	No	8	8
105	3x48	5x53	5ht2_off	2.12933	0	No	No	No	No	6	6
106	5x37	E3	5ht2_off	2.028	0	No	No	No	No	4	3
107	1x40	1x44	5ht2_off	2.00333	0	No	No	No	No	3	4
108	5x41	6x56	5ht2_off	1.998	0	No	No	No	No	6	5
109	7x54	8x51	5ht2_off	1.98267	0	No	No	No	No	7	9
110	7x52	7x56	5ht2_off	1.92133	0	No	No	Yes	No	8	7
111	6x49	6x50	5ht2_off	1.88	0	No	No	No	No	6	9
112	1x58	2x44	5ht2_off	1.84067	0	No	No	Yes	No	1	5
113	3x48	3x52	5ht2_off	1.818	0	No	No	No	No	6	5
114	1x36	2x65	5ht2_off	1.79733	0	No	No	No	No	6	5
115	6x56	6x60	5ht2_off	1.734	0	No	No	No	No	5	4
116	5x51	5x55	5ht2_off	1.72467	0	No	No	No	No	6	5
117	7x36	7x37	5ht2_off	1.71	0	No	No	Yes	No	4	5
118	7x43	7x48	5ht2_off	1.656	0	No	No	No	No	4	6
119	5x68	6x27	5ht2_off	1.64	0	No	No	No	No	7	5
120	6x43	6x47	5ht2_off	1.57867	0	No	No	No	No	6	8
121	8x55	8x56	5ht2_off	1.49	0	No	No	No	No	3	4
122	5x59	5x63	5ht2_off	1.488	0	No	No	No	No	1	4
123	I2x52	I2x53	5ht2_off	1.43333	0	No	No	No	No	5	7
124	6x26	6x30	5ht2_off	1.41	0	No	No	Yes	No	5	8
125	6x30	I2x53	5ht2_off	1.39533	0	Yes	No	No	No	8	7
126	4x47	4x51	5ht2_off	1.28733	0	No	No	No	No	2	4
127	5x43	Lig	5ht2_off	1.248	0	No	No	Yes	Yes	6	0
128	4x39	I2x57	5ht2_off	1.20667	0	No	Yes	No	No	4	6
129	1x33	1x37	5ht2_off	1.14	0	No	No	No	No	5	4
130	5x52	5x56	5ht2_off	1.01333	0	No	No	No	No	3	5
131	6x28	6x32	5ht2_off	1.00867	0	No	No	No	No	6	8
132	4x55	4x59	5ht2_off	0.963333	0	No	No	No	No	4	4
133	1x35	2x64	5ht2_off	0.953333	0	Yes	No	No	No	3	5
134	6x45	6x46	5ht2_off	0.95	0	No	No	No	No	6	5
135	1x28	1x32	5ht2_off	0.873333	0	No	No	No	No	3	6
136	4x38	4x40	5ht2_off	0.853333	0	No	No	No	No	7	5
137	6x57	6x60	5ht2_off	0.849333	0	No	No	No	No	4	4
138	1x35	1x38	5ht2_off	0.76	0	Yes	No	No	No	3	4
139	1x29	1x33	5ht2_off	0.732	0	No	No	No	No	3	5
140	1x27	1x30	5ht2_off	0.661333	0	No	No	No	No	2	1
141	I2x54	I2x56	5ht2_off	0.616	0	No	No	No	No	6	4
142	3x53	3x54	5ht2_off	0.54	0	No	No	No	No	8	9
143	3x24	3x27	5ht2_off	0.526667	0	Yes	No	No	No	5	4
144	1x411	1x42	5ht2_off	0.506667	0	No	No	No	No	0	7
145	I2x52	I2x54	5ht2_off	0.48	0	No	No	No	No	5	6
146	6x27	6x28	5ht2_off	0.473333	0	No	No	No	No	5	6
147	1x30	1x32	5ht2_off	0.452	0	No	No	No	No	1	6
148	5x66	5x67	5ht2_off	0.356667	0	No	No	No	No	6	5
149	1x28	1x31	5ht2_off	0.328	0	No	No	No	No	3	3
150	4x51	4x52	5ht2_off	0.202667	0	No	No	No	No	4	5
151	4x63	4x67	5ht2_off	0.190667	0	No	No	No	No	5	6
152	1x42	7x43	Shared	5.08733	3.21	No	No	No	No	7	4
153	1x43	2x57	Shared	5.34333	5.83	No	No	Yes	Yes	6	8
154	1x46	7x47	Shared	4.536	3.64	No	No	No	No	7	6
155	1x47	2x55	Shared	7.516	2.85	No	No	No	No	5	4
156	1x50	2x50	Shared	7.80867	4.04	Yes	Yes	Yes	Yes	9	9
157	1x50	7x50	Shared	7.168	9.77	Yes	Yes	No	No	9	9
158	1x51	2x51	Shared	3.89733	2.95	No	No	No	No	3	7
159	1x52	8x54	Shared	8.04	6.09	No	No	Yes	No	6	6
160	1x57	2x44	Shared	8.62333	6.09	No	No	Yes	No	7	5
161	8x49	I1x50	Shared	6.982	5.9	No	No	Yes	No	6	8
162	8x50	I1x50	Shared	11.6567	14.61	Yes	Yes	Yes	No	8	8
163	2x41	I1x51	Shared	4.74467	2.25	Yes	No	No	No	4	7
164	2x37	2x40	Shared	12.5107	15.12	No	No	No	No	7	9
165	2x40	8x50	Shared	5.856	6.04	No	No	Yes	Yes	9	8
166	2x41	4x39	Shared	9.05533	13.38	Yes	No	No	Yes	4	4
167	2x42	3x42	Shared	3.62	5.66	Yes	No	Yes	Yes	8	8
168	2x42	4x45	Shared	4.38133	3.72	Yes	No	No	No	8	6
169	2x45	3x42	Shared	8.64867	8.37	No	No	Yes	Yes	9	8
170	2x45	4x46	Shared	6.81	9.29	No	No	No	No	9	8
171	2x45	4x50	Shared	6.18	6.18	No	No	Yes	Yes	9	9
172	2x46	2x50	Shared	4.88533	4.07	No	No	Yes	Yes	9	9
173	2x50	3x39	Shared	7.46333	5.89	Yes	Yes	No	No	9	9
174	2x50	7x46	Shared	6.86867	8.83	Yes	Yes	No	No	9	9
175	2x52	3x35	Shared	12.7473	9.74	No	No	Yes	Yes	7	7
176	2x53	3x35	Shared	4.45733	3.93	No	No	Yes	Yes	7	7
177	2x53	7x46	Shared	3.79333	6.46	No	No	No	No	7	9
178	2x54	2x57	Shared	4.77333	3.49	No	No	Yes	Yes	6	8
179	2x56	3x28	Shared	4.168	6.13	No	No	Yes	No	8	5
180	2x56	3x32	Shared	6.91133	2.92	No	No	No	Yes	8	8
181	2x56	7x42	Shared	4.04067	3.79	No	No	Yes	Yes	8	7
182	2x57	7x39	Shared	6.20267	3.49	Yes	Yes	Yes	Yes	8	6
183	2x57	7x42	Shared	6.14467	4.79	Yes	Yes	Yes	Yes	8	7
184	2x59	3x28	Shared	12.3473	7.05	No	No	Yes	No	4	5
185	2x60	7x39	Shared	6.71	3.89	No	No	Yes	Yes	7	6
186	2x64	7x39	Shared	4.854	3.52	No	No	Yes	Yes	5	6
187	E1x50	E1x51	Shared	5.4	5.4	Yes	Yes	No	No	7	3
188	E1x50	E1x52	Shared	8.73	4.56	Yes	Yes	No	Yes	7	5
189	3x25	E1x50	Shared	6.44333	5.22	No	No	Yes	Yes	9	7
190	3x28	E1x50	Shared	7.06067	4.69	Yes	No	Yes	Yes	5	7
191	E1x50	E2x50	Shared	13.4073	10.45	Yes	Yes	No	No	7	9
192	3x21	E1x52	Shared	4.272	4.93	No	No	No	Yes	7	5
193	3x21	3x24	Shared	3.502	4.93	No	No	Yes	No	7	5
194	3x22	E2	Shared	15.904	4.49	No	No	Yes	Yes	3	3
195	3x25	E2x50	Shared	7.28	7.28	No	No	No	No	9	9
196	3x30	4x62	Shared	10.4033	13	No	No	No	No	6	5
197	3x31	3x35	Shared	4.464	3.65	No	No	Yes	Yes	5	7
198	3x32	7x42	Shared	7.51267	10.34	No	Yes	Yes	Yes	8	7
199	3x32	Lig	Shared	15.7673	18.04	No	Yes	Yes	Yes	8	0
200	3x33	4x57	Shared	3.71533	3.39	No	No	No	No	6	7
201	3x33	Lig	Shared	7.64467	15.14	No	No	Yes	Yes	6	0
202	3x34	3x35	Shared	6.17133	3.65	No	No	Yes	Yes	6	7
203	3x36	Lig	Shared	10.842	5.87	No	No	Yes	Yes	7	0
204	3x37	5x461	Shared	4.73467	3.36	No	No	No	No	7	6
205	3x38	4x50	Shared	5.88067	3.89	No	No	Yes	Yes	8	9
206	3x40	5x50	Shared	4.40533	3.39	No	No	Yes	No	8	9
207	3x40	6x44	Shared	5.36	3.77	No	No	Yes	No	8	9
208	3x41	5x50	Shared	10.956	8.11	No	No	Yes	No	6	9
209	3x42	4x49	Shared	7.38067	5.54	Yes	Yes	No	No	8	6
210	3x42	4x50	Shared	7.05533	4.23	Yes	Yes	Yes	Yes	8	9
211	3x44	5x53	Shared	4.582	3.27	No	No	No	No	6	6
212	3x47	5x57	Shared	4.05267	4.8	No	No	No	No	9	5
213	3x49	4x45	Shared	10.0467	12.44	No	No	No	No	9	6
214	3x50	6x37	Shared	3.80467	4.86	Yes	No	No	No	9	8
215	3x51	3x55	Shared	6.61467	7.17	Yes	No	No	No	8	6
216	3x51	5x60	Shared	9.61267	1.17	Yes	No	No	No	8	5
217	3x51	5x61	Shared	5.82467	6.24	Yes	No	No	No	8	9
218	3x54	5x64	Shared	3.72667	1.62	No	No	No	No	9	6
219	3x54	5x65	Shared	3.804	7.14	No	No	No	No	9	8
220	4x39	4x43	Shared	4.98733	2.14	No	Yes	No	No	4	4
221	4x59	4x60	Shared	4.13133	5.08	No	No	No	No	4	7
222	4x61	5x39	Shared	4.34267	3.93	No	No	No	No	6	7
223	4x64	E2	Shared	5.418	3.71	No	No	Yes	Yes	4	3
224	E2	E2	Shared	30.3533	68.13	Yes	Yes	Yes	Yes	3	3
225	5x36	E2	Shared	12.584	5.54	Yes	No	Yes	Yes	5	3
226	E2	E2x51	Shared	6.09533	1.59	Yes	Yes	No	No	3	4
227	5x40	6x55	Shared	4.872	7.01	No	No	No	No	6	7
228	5x44	6x52	Shared	4.84	3.96	No	No	Yes	Yes	6	7
229	5x45	5x48	Shared	4.122	3.65	No	No	No	No	4	5
230	5x47	5x48	Shared	6.28933	9.65	No	Yes	No	No	8	5
231	5x47	6x52	Shared	27.148	18.22	No	Yes	Yes	Yes	8	7
232	5x49	5x50	Shared	4.01	5.25	No	No	Yes	No	5	9
233	5x51	6x45	Shared	5.938	4.15	No	No	No	No	6	6
234	5x54	6x41	Shared	7.21333	3.73	No	No	Yes	No	8	8
235	5x58	5x62	Shared	6.60933	12.09	Yes	Yes	No	No	9	5
236	5x58	6x38	Shared	3.86267	4.35	Yes	Yes	No	No	9	6
237	5x65	6x30	Shared	3.79933	5.3	No	No	Yes	No	8	8
238	5x68	6x30	Shared	4.89533	4.05	No	No	Yes	No	7	8
239	6x42	6x46	Shared	3.46667	3.65	No	No	No	No	5	5
240	6x47	7x45	Shared	8.87133	4.6	No	No	No	No	8	9
241	6x48	6x52	Shared	5.81267	8.02	Yes	No	Yes	Yes	8	7
242	6x48	7x41	Shared	12.2	8.44	Yes	No	No	No	8	7
243	6x50	7x37	Shared	10.1107	7.22	No	No	Yes	No	9	5
244	6x51	6x52	Shared	7.71667	5.36	Yes	Yes	Yes	Yes	7	7
245	6x51	7x34	Shared	4.79	4.87	Yes	Yes	No	No	7	3
246	6x51	7x38	Shared	4.62867	3.93	Yes	Yes	No	No	7	6
247	6x51	Lig	Shared	12.1447	15.23	Yes	Yes	Yes	Yes	7	0
248	6x54	7x34	Shared	5.89733	7.37	No	No	No	No	5	3
249	6x54	7x37	Shared	6.65867	2.59	No	No	Yes	No	5	5
250	6x58	7x30	Shared	5.676	2.77	No	No	No	No	4	4
251	6x61	E3	Shared	8.88533	10.72	No	No	No	No	3	3
252	7x26	7x29	Shared	6.15133	5.85	No	No	No	No	1	5
253	7x38	7x42	Shared	4.71067	6.31	No	No	Yes	Yes	6	7
254	7x38	Lig	Shared	7.194	4.66	No	No	Yes	Yes	6	0
255	7x39	7x42	Shared	10.032	3.86	Yes	Yes	Yes	Yes	6	7
256	7x51	7x55	Shared	3.78333	2.77	No	No	No	No	6	5
257	8x47	8x49	Shared	6.12867	5.85	No	No	No	No	9	6
258	2x46	3x42	Shared	6.42733	9	No	No	Yes	Yes	9	8
259	3x41	4x52	Shared	5.20133	10.57	No	No	No	No	6	5
260	7x27	E2	Shared	5.03	2.71	No	No	Yes	Yes	3	3
261	5x58	5x59	Shared	3.746	8.25	Yes	Yes	No	No	9	1
262	3x43	7x49	Shared	3.66	4.12	No	No	No	No	8	9
263	7x54	8x50	Shared	3.89	9.08	No	No	Yes	Yes	7	8
264	5x58	6x41	Shared	3.438	5.16	Yes	Yes	Yes	No	9	8
265	4x61	4x62	Shared	3.43667	3.53	No	No	No	No	6	5
266	3x38	4x53	Shared	3.42	3.42	No	No	No	No	8	8
267	1x57	8x50	Shared	3.4	2.62	No	No	Yes	Yes	7	8
268	7x26	7x28	Shared	3.326	5.85	No	No	No	No	1	2
269	5x44	6x56	Shared	3.3	3.1	No	No	No	No	6	5
270	2x42	3x45	Shared	3.23467	2.77	Yes	No	No	No	8	7
271	2x55	2x551	Shared	3.034	6.09	No	No	No	No	4	5
272	1x42	2x57	Shared	3	3.04	No	No	Yes	Yes	7	8
273	5x56	5x60	Shared	2.89333	2.98	No	No	No	No	5	5
274	6x47	7x40	Shared	2.82267	2.92	No	No	No	No	8	7
275	3x34	4x54	Shared	2.81733	2.85	No	No	No	No	6	4
276	1x50	2x51	Shared	2.76333	6.87	Yes	Yes	No	No	9	7
277	1x54	2x44	Shared	2.72267	2.92	No	No	Yes	No	6	5
278	1x56	8x50	Shared	2.70333	2.77	No	No	Yes	Yes	7	8
279	2x49	4x50	Shared	2.59	2.59	No	No	Yes	Yes	8	9
280	3x23	3x24	Shared	2.55667	2.98	No	No	Yes	No	1	5
281	5x41	5x42	Shared	2.532	8.53	No	No	No	No	6	4
282	2x63	E1x50	Shared	2.48333	2.43	No	No	Yes	Yes	5	7
283	6x36	7x56	Shared	2.44533	15.73	No	No	Yes	No	8	7
284	3x56	I2x50	Shared	2.40333	1.67	No	No	No	No	6	8
285	1x48	1x51	Shared	2.37	1.82	No	No	No	No	4	3
286	6x40	7x52	Shared	2.35133	3.21	No	No	No	No	8	8
287	3x37	4x56	Shared	2.33067	3.04	No	No	No	No	7	6
288	3x55	3x56	Shared	2.32	1.44	No	No	No	No	6	6
289	6x49	6x53	Shared	2.182	1.64	No	No	No	No	6	6
290	1x52	8x58	Shared	2.15867	4.28	No	No	No	Yes	6	6
291	8x48	8x51	Shared	2.14733	6.19	No	No	No	No	5	9
292	6x29	6x32	Shared	2.14	10.85	No	No	No	No	6	8
293	1x40	2x61	Shared	2.09067	5.71	No	No	No	No	3	6
294	2x65	2x66	Shared	2.02333	3.73	No	No	No	No	5	4
295	4x56	5x46	Shared	2.006	1.62	No	No	No	No	6	4
296	7x32	7x35	Shared	1.82	2.71	No	No	No	No	1	4
297	5x62	5x66	Shared	1.73733	4.12	No	No	No	No	5	6
298	2x38	I2x57	Shared	1.56333	4.69	No	No	No	No	5	6
299	2x41	4x42	Shared	1.51	1.33	Yes	No	No	No	4	7
300	E1x49	E2	Shared	1.19667	15.43	No	No	Yes	Yes	4	3
301	1x44	1x45	Shared	1.13	3.39	No	No	No	No	4	4
302	4x48	4x52	Shared	1.02333	1.54	No	No	No	No	2	5
303	1x40	7x39	5ht2_on	0	8.22	No	No	Yes	Yes	3	6
304	1x43	2x58	5ht2_on	0	3.39	No	No	No	No	6	8
305	1x46	1x50	5ht2_on	0	2.92	No	No	Yes	Yes	7	9
306	1x53	7x54	5ht2_on	0	4.76	No	No	No	No	9	7
307	1x55	8x58	5ht2_on	0	4.28	No	No	No	Yes	4	6
308	1x59	8x58	5ht2_on	0	5.71	No	No	No	Yes	5	6
309	1x60	8x53	5ht2_on	0	6.03	No	No	No	No	6	7
310	I1x48	I1x51	5ht2_on	0	4.07	No	No	No	No	6	7
311	2x50	7x49	5ht2_on	0	8.08	Yes	Yes	No	No	9	9
312	2x52	2x551	5ht2_on	0	3.65	No	No	No	No	7	5
313	E1	E1x49	5ht2_on	0	7.02	No	No	No	No	3	4
314	E1x51	E1x52	5ht2_on	0	3.28	No	No	No	Yes	3	5
315	3x25	3x26	5ht2_on	0	3.77	No	No	No	No	9	6
316	3x29	4x61	5ht2_on	0	4.47	No	No	No	No	5	6
317	3x29	E2x52	5ht2_on	0	5.54	No	No	No	No	5	4
318	3x32	3x36	5ht2_on	0	4.42	No	Yes	No	No	8	7
319	3x34	4x53	5ht2_on	0	3	No	No	No	No	6	8
320	3x37	4x53	5ht2_on	0	6.4	No	No	No	No	7	8
321	3x38	3x42	5ht2_on	0	2.93	No	No	Yes	Yes	8	8
322	3x43	7x53	5ht2_on	0	8.21	No	No	Yes	Yes	8	9
323	3x44	5x54	5ht2_on	0	4.86	No	No	No	No	6	8
324	3x46	3x50	5ht2_on	0	6.26	No	No	Yes	No	9	9
325	3x46	7x53	5ht2_on	0	3.63	No	No	Yes	Yes	9	9
326	3x50	7x53	5ht2_on	0	6.17	Yes	No	Yes	Yes	9	9
327	3x56	I2x52	5ht2_on	0	6.78	No	No	No	No	6	5
328	I2x51	I2x52	5ht2_on	0	6.86	No	No	No	No	7	5
329	I2x51	I2x55	5ht2_on	0	4.12	No	No	No	No	7	4
330	I2x52	I2x56	5ht2_on	0	3.38	No	No	No	No	5	4
331	4x46	4x50	5ht2_on	0	3.52	No	No	Yes	Yes	8	9
332	4x52	4x56	5ht2_on	0	2.94	No	No	No	No	5	6
333	5x36	E2x52	5ht2_on	0	12.18	Yes	No	No	No	5	4
334	6x58	E2	5ht2_on	0	4.23	No	No	Yes	Yes	4	3
335	5x39	5x43	5ht2_on	0	3.01	No	No	No	No	7	6
336	5x39	Lig	5ht2_on	0	2.86	No	No	Yes	Yes	7	0
337	5x40	6x59	5ht2_on	0	3.04	No	No	No	No	6	5
338	5x47	5x51	5ht2_on	0	3.65	No	Yes	No	No	8	6
339	5x47	6x44	5ht2_on	0	3.22	No	Yes	Yes	No	8	9
340	5x47	6x48	5ht2_on	0	3.01	No	Yes	Yes	No	8	8
341	5x47	6x49	5ht2_on	0	4.19	No	Yes	No	No	8	6
342	5x53	5x57	5ht2_on	0	3.04	No	No	No	No	6	5
343	5x54	6x44	5ht2_on	0	8.71	No	No	Yes	No	8	9
344	5x67	6x30	5ht2_on	0	9.45	No	No	Yes	No	5	8
345	5x68	6x28	5ht2_on	0	7.65	No	No	No	No	7	6
346	6x27	6x31	5ht2_on	0	4.12	No	No	No	No	5	5
347	6x27	6x35	5ht2_on	0	5.82	No	No	No	No	5	7
348	6x28	6x31	5ht2_on	0	7.22	No	No	No	No	6	5
349	6x31	6x34	5ht2_on	0	2.89	No	No	No	No	5	7
350	6x40	7x53	5ht2_on	0	5.05	No	No	Yes	Yes	8	9
351	6x45	6x49	5ht2_on	0	4.76	No	No	No	No	6	6
352	6x59	6x60	5ht2_on	0	2.98	No	No	No	No	5	4
353	7x45	7x49	5ht2_on	0	4.47	No	No	No	No	9	9
354	7x48	7x52	5ht2_on	0	3.21	No	No	No	No	6	8
355	7x50	7x51	5ht2_on	0	3.28	No	No	No	No	9	6
356	7x54	7x55	5ht2_on	0	2.95	No	No	No	No	7	5
357	1x47	2x51	5ht2_on	0	2.85	No	No	No	No	5	7
358	1x56	8x54	5ht2_on	0	2.77	No	No	Yes	No	7	6
359	E2	E3	5ht2_on	0	2.77	Yes	Yes	No	No	3	3
360	5x41	6x60	5ht2_on	0	2.77	No	No	No	No	6	4
361	2x40	2x43	5ht2_on	0	2.75	No	No	No	No	9	8
362	1x60	8x58	5ht2_on	0	2.73	No	No	No	Yes	6	6
363	1x35	1x37	5ht2_on	0	2.59	Yes	No	No	No	3	4
364	5x55	5x59	5ht2_on	0	2.51	No	No	No	No	5	1
365	6x27	6x32	5ht2_on	0	2.51	No	No	No	No	5	8
366	2x37	2x39	5ht2_on	0	2.5	No	No	No	No	7	8
367	7x55	8x51	5ht2_on	0	2.43	No	No	No	No	5	9
368	6x55	Lig	5ht2_on	0	2.15	No	No	Yes	Yes	7	0
369	1x48	1x49	5ht2_on	0	2.11	No	No	No	No	4	8
370	3x53	I2x53	5ht2_on	0	1.79	No	No	No	No	8	7
371	4x54	4x55	5ht2_on	0	1.76	No	No	No	No	4	4
372	3x44	3x48	5ht2_on	0	1.71	No	No	No	No	6	6
373	1x53	2x47	5ht2_on	0	1.7	No	No	No	No	9	9
374	6x57	6x61	5ht2_on	0	1.69	No	No	No	No	4	3
375	6x57	E3	5ht2_on	0	1.69	No	No	No	No	4	3
376	3x52	I2x53	5ht2_on	0	1.62	No	No	No	No	5	7
377	1x37	2x65	5ht2_on	0	1.61	No	No	No	No	4	5
378	3x55	5x64	5ht2_on	0	1.61	No	No	No	No	6	6
379	5x65	6x33	5ht2_on	0	1.58	No	No	No	No	8	8
380	1x54	1x58	5ht2_on	0	1.55	No	No	No	No	6	1
381	4x44	4x47	5ht2_on	0	1.52	No	No	No	No	3	2
382	8x49	I1x49	5ht2_on	0	1.5	No	No	No	No	6	6
383	6x43	7x48	5ht2_on	0	1.49	No	No	No	No	6	6
384	6x43	7x52	5ht2_on	0	1.49	No	No	No	No	6	8
385	4x54	4x59	5ht2_on	0	1.47	No	No	No	No	4	4
386	5x61	6x37	5ht2_on	0	1.47	No	No	No	No	9	8
387	2x39	I2x57	5ht2_on	0	1.46	No	No	No	No	8	6
388	4x41	I2x57	5ht2_on	0	1.46	No	No	No	No	6	6
389	1x40	1x41	5ht2_on	0	1.43	No	No	No	No	3	4
390	3x27	3x30	5ht2_on	0	1.39	No	No	No	No	4	6
391	2x38	4x39	5ht2_on	0	1.38	No	No	No	Yes	5	4
392	2x62	E1x52	5ht2_on	0	1.38	No	No	No	Yes	4	5
393	7x30	7x33	5ht2_on	0	1.38	No	No	No	No	4	4
394	6x58	7x31	5ht2_on	0	1.33	No	No	No	No	4	2
395	4x38	4x39	5ht2_on	0	1.32	No	No	No	Yes	7	4
396	2x62	2x66	5ht2_on	0	1.22	No	No	No	No	4	4
397	8x56	8x57	5ht2_on	0	1.03	No	No	Yes	No	4	4

Orange: nodes, hubs and links specific of 5ht2_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of 5ht2_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	5ht2_off Avg Int. Strength	5ht2_on Avg Int. Strength	5ht2_off Num Of Links	5ht2_on Num Of Links	ConSurf
1	1x35	5ht2_off	2.71617	2.59	4	1	3
2	I1x50	5ht2_off	7.45067	10.255	4	2	8
3	2x41	5ht2_off	4.77853	5.65333	5	3	4
4	2x42	5ht2_off	4.17373	4.05	5	3	8
5	2x44	5ht2_off	4.015	4.505	4	2	5
6	3x24	5ht2_off	2.9615	3.955	4	2	5
7	3x28	5ht2_off	6.74017	5.95667	4	3	5
8	3x50	5ht2_off	3.24293	5.76333	5	3	9
9	3x51	5ht2_off	6.158	4.86	4	3	8
10	5x36	5ht2_off	6.42333	8.86	4	2	5
11	5x50	5ht2_off	5.628	5.58333	4	3	9
12	6x30	5ht2_off	3.15267	6.26667	5	3	8
13	6x41	5ht2_off	6.2536	4.445	5	2	8
14	6x44	5ht2_off	6.9972	5.23333	5	3	9
15	6x48	5ht2_off	8.72693	6.49	5	3	8
16	7x37	5ht2_off	6.30483	4.905	4	2	5
17	7x56	5ht2_off	2.73967	15.73	4	1	7
18	8x54	5ht2_off	5.7135	4.43	4	2	6
19	8x57	5ht2_off	4.98347	1.03	5	1	4
20	NT	5ht2_off	11.6183	0	6	0	0
21	1x50	Shared	5.34667	5.9	4	4	9
22	2x50	Shared	6.7565	6.182	4	5	9
23	2x57	Shared	4.67429	4.128	7	5	8
24	E1x50	Shared	6.77124	5.45833	7	6	7
25	3x35	Shared	6.33	5.2425	5	4	7
26	3x42	Shared	6.6264	5.955	5	6	8
27	4x50	Shared	5.1032	4.082	5	5	9
28	E2	Shared	10.7354	17.673	13	10	3
29	5x58	Shared	4.414	7.4625	4	4	9
30	6x51	Shared	7.08111	7.3475	6	4	7
31	6x52	Shared	11.484	8.89	5	4	7
32	7x39	Shared	8.7404	4.596	5	5	6
33	7x42	Shared	6.09611	5.818	6	5	7
34	7x53	Shared	5.18267	5.765	4	4	9
35	8x50	Shared	5.77308	7.024	8	5	8
36	Lig	Shared	7.79039	9.13571	12	7	0
37	E1x52	5ht2_on	6.08756	3.5375	3	4	5
38	3x32	5ht2_on	10.0638	8.93	3	4	8
39	4x39	5ht2_on	5.08311	4.555	3	4	4
40	5x47	5ht2_on	12.3376	6.99	3	6	8
41	8x58	5ht2_on	2.15867	4.25	1	4	6

Orange: nodes, hubs and links specific of 5ht2_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of 5ht2_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	5ht2_off Recurrence	5ht2_on Recurrence	5ht2_off Hub1?	5ht2_on Hub1?	5ht2_off Hub2?	5ht2_on Hub2?	ConSurf1	ConSurf2
1	7x39	7x42	5ht2_off	31.1709	9.35532	Yes	Yes	Yes	Yes	6	7
2	7x42	Lig	5ht2_off	44.1857	0	Yes	Yes	Yes	Yes	7	0
3	6x48	Lig	5ht2_off	71.8635	0	Yes	No	Yes	Yes	8	0
4	6x44	6x48	5ht2_off	97.8779	0	Yes	No	Yes	No	9	8
5	3x39	6x44	5ht2_off	42.9709	0	No	No	Yes	No	9	9
6	2x50	3x39	5ht2_off	18.2519	1.68424	Yes	Yes	No	No	9	9
7	3x43	6x44	5ht2_off	100	0	No	No	Yes	No	8	9
8	7x49	7x53	5ht2_off	60.7894	0	No	No	Yes	Yes	9	9
9	1x53	7x53	5ht2_off	12.672	0	No	No	Yes	Yes	9	9
10	1x53	8x54	5ht2_off	11.7244	0	No	No	Yes	No	9	6
11	1x52	8x54	5ht2_off	22.1231	9.92853	No	No	Yes	No	6	6
12	7x53	8x50	5ht2_off	46.5296	0	Yes	Yes	Yes	Yes	9	8
13	8x50	8x54	5ht2_off	12.8383	0	Yes	Yes	Yes	No	8	6
14	1x52	8x57	5ht2_off	17.1329	0	No	No	Yes	No	6	4
15	1x57	8x50	5ht2_off	15.7266	6.49636	No	No	Yes	Yes	7	8
16	1x57	2x44	5ht2_off	14.658	5.01734	No	No	Yes	No	7	5
17	2x46	3x39	5ht2_off	23.6302	0	No	No	No	No	9	9
18	2x42	3x42	5ht2_off	14.0481	6.34775	Yes	No	Yes	Yes	8	8
19	3x33	Lig	5ht2_off	19.7742	3.27648	No	No	Yes	Yes	6	0
20	3x33	4x57	5ht2_off	10.4945	1.64178	No	No	No	No	6	7
21	2x64	7x39	5ht2_off	22.7431	1.53563	No	No	Yes	Yes	5	6
22	2x64	E1	5ht2_off	12.1175	0	No	No	No	No	5	3
23	E2x51	Lig	5ht2_off	28.2524	0	No	No	Yes	Yes	4	0
24	E2	E2x51	5ht2_off	27.4207	1.59932	Yes	Yes	No	No	3	4
25	3x33	4x61	5ht2_off	11.0792	0	No	No	No	No	6	6
26	3x43	6x41	5ht2_off	58.2489	0	No	No	Yes	No	8	8
27	3x47	6x41	5ht2_off	15.8425	0	No	No	Yes	No	9	8
28	3x47	5x57	5ht2_off	14.5118	1.67716	No	No	No	No	9	5
29	6x37	6x41	5ht2_off	28.9581	0	No	No	Yes	No	8	8
30	3x51	5x57	5ht2_off	13.1055	0	Yes	No	No	No	8	5
31	3x50	6x30	5ht2_off	23.3278	0	Yes	No	Yes	No	9	8
32	5x44	6x52	5ht2_off	14.1691	3.34725	No	No	Yes	Yes	6	7
33	5x58	6x41	5ht2_off	11.1145	9.87191	Yes	Yes	Yes	No	9	8
34	6x40	7x49	5ht2_off	11.6891	0	No	No	No	No	8	9
35	6x51	7x34	5ht2_off	20.8629	6.64497	Yes	Yes	No	No	7	3
36	6x54	7x34	5ht2_off	19.8347	5.00318	No	No	No	No	5	3
37	6x54	7x37	5ht2_off	15.0108	3.34725	No	No	Yes	No	5	5
38	5x44	6x56	5ht2_off	12.7678	1.67716	No	No	No	No	6	5
39	6x40	7x52	5ht2_off	10.2525	5.01026	No	No	No	No	8	8
40	1x35	2x64	5ht2_off	11.2657	0	Yes	No	No	No	3	5
41	E1x50	E2	5ht2_off	15.8173	0	Yes	Yes	Yes	Yes	7	3
42	6x48	6x51	5ht2_off	14.4463	0	Yes	No	Yes	Yes	8	7
43	6x48	6x52	5ht2_off	11.2657	1.29503	Yes	No	Yes	Yes	8	7
44	1x50	2x50	Shared	14.3606	62.4089	Yes	Yes	Yes	Yes	9	9
45	3x43	7x49	Shared	69.2626	49.0907	No	No	No	No	8	9
46	2x46	3x42	Shared	23.5244	85.132	No	No	Yes	Yes	9	8
47	3x40	6x44	Shared	17.2942	99.9151	No	No	Yes	No	8	9
48	3x40	5x50	Shared	15.9081	99.9575	No	No	Yes	No	8	9
49	3x50	6x37	Shared	27.6274	39.0064	Yes	No	No	No	9	8
50	2x57	7x42	Shared	13.2063	10.2257	Yes	Yes	Yes	Yes	8	7
51	7x38	7x42	5ht2_on	3.66954	36.3881	No	No	Yes	Yes	6	7
52	6x51	7x38	5ht2_on	4.31473	34.5977	Yes	Yes	No	No	7	6
53	6x51	6x52	5ht2_on	1.24502	93.1993	Yes	Yes	Yes	Yes	7	7
54	5x47	6x52	5ht2_on	2.8076	93.1286	No	Yes	Yes	Yes	8	7
55	5x47	6x44	5ht2_on	0	97.6152	No	Yes	Yes	No	8	9
56	3x41	5x50	5ht2_on	7.3794	100	No	No	Yes	No	6	9
57	3x41	4x52	5ht2_on	5.92268	100	No	No	No	No	6	5
58	4x52	4x56	5ht2_on	0	99.9575	No	No	No	No	5	6
59	3x37	4x56	5ht2_on	2.92858	99.8585	No	No	No	No	7	6
60	3x37	4x53	5ht2_on	0	99.7028	No	No	No	No	7	8
61	3x38	4x53	5ht2_on	1.59786	88.7765	No	No	No	No	8	8
62	3x38	3x42	5ht2_on	0	84.5871	No	No	Yes	Yes	8	8
63	2x46	2x50	5ht2_on	1.12909	84.7852	No	No	Yes	Yes	9	9
64	1x50	7x50	5ht2_on	2.94874	55.0067	Yes	Yes	No	No	9	9
65	7x50	7x51	5ht2_on	0	53.8532	No	No	No	No	9	6
66	7x51	7x55	5ht2_on	1.49201	52.6856	No	No	No	No	6	5
67	7x54	7x55	5ht2_on	0	49.0977	No	No	No	No	7	5
68	7x54	8x50	5ht2_on	5.49927	45.3613	No	No	Yes	Yes	7	8
69	1x56	8x50	5ht2_on	1.44665	13.1272	No	No	Yes	Yes	7	8
70	1x56	8x54	5ht2_on	0	11.5349	No	No	Yes	No	7	6
71	2x40	8x50	5ht2_on	2.54045	22.0508	No	No	Yes	Yes	9	8
72	2x37	2x40	5ht2_on	1.4416	19.1848	No	No	No	No	7	9
73	2x37	2x39	5ht2_on	0	17.6491	No	No	No	No	7	8
74	2x39	I2x57	5ht2_on	0	16.0923	No	No	No	No	8	6
75	2x38	I2x57	5ht2_on	1.4416	13.1201	No	No	No	No	5	6
76	2x38	4x39	5ht2_on	0	11.5349	No	No	No	Yes	5	4
77	3x34	4x53	5ht2_on	0	12.5327	No	No	No	No	6	8
78	3x34	3x35	5ht2_on	7.19794	11.0466	No	No	Yes	Yes	6	7
79	2x50	7x49	5ht2_on	0	53.8462	Yes	Yes	No	No	9	9
80	2x56	7x42	5ht2_on	6.63844	21.2582	No	No	Yes	Yes	8	7
81	2x56	3x28	5ht2_on	8.51857	42.5589	No	No	Yes	No	8	5
82	3x28	E1x50	5ht2_on	2.2985	37.8671	Yes	No	Yes	Yes	5	7
83	E1x50	E1x52	5ht2_on	7.3794	23.0911	Yes	Yes	No	Yes	7	5
84	2x62	E1x52	5ht2_on	0	12.9078	No	No	No	Yes	4	5
85	2x62	2x66	5ht2_on	0	10.3107	No	No	No	No	4	4
86	3x32	Lig	5ht2_on	5.32285	27.4857	No	Yes	Yes	Yes	8	0
87	5x39	Lig	5ht2_on	0	33.0621	No	No	Yes	Yes	7	0
88	4x61	5x39	5ht2_on	8.06996	30.5145	No	No	No	No	6	7
89	3x29	4x61	5ht2_on	0	25.023	No	No	No	No	5	6
90	3x29	E2x52	5ht2_on	0	23.6784	No	No	No	No	5	4
91	5x36	E2x52	5ht2_on	0	22.4117	Yes	No	No	No	5	4
92	5x36	E2	5ht2_on	4.12823	20.961	Yes	No	Yes	Yes	5	3
93	3x43	7x53	5ht2_on	0	47.831	No	No	Yes	Yes	8	9
94	5x54	6x44	5ht2_on	0	20.4586	No	No	Yes	No	8	9
95	3x50	7x53	5ht2_on	0	39.983	Yes	No	Yes	Yes	9	9
96	5x61	6x37	5ht2_on	0	37.8459	No	No	No	No	9	8
97	3x51	5x61	5ht2_on	1.49201	36.5013	Yes	No	No	No	8	9
98	3x51	3x55	5ht2_on	5.92268	32.3615	Yes	No	No	No	8	6
99	3x55	5x64	5ht2_on	0	22.2065	No	No	No	No	6	6
100	3x54	5x64	5ht2_on	1.48697	20.6992	No	No	No	No	9	6
101	3x54	5x65	5ht2_on	4.41555	19.1777	No	No	No	No	9	8
102	5x54	6x41	5ht2_on	8.82605	11.4712	No	No	Yes	No	8	8
103	5x65	6x30	5ht2_on	5.60008	16.2692	No	No	Yes	No	8	8
104	5x68	6x30	5ht2_on	9.97026	13.113	No	No	Yes	No	7	8
105	5x68	6x28	5ht2_on	0	11.5278	No	No	No	No	7	6
106	6x51	Lig	5ht2_on	8.68995	56.2593	Yes	Yes	Yes	Yes	7	0
107	2x56	3x32	5ht2_on	4.23912	23.7209	No	No	No	Yes	8	8

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
2x56	3x32	Shared	6.91133	2.92	1	1	2	1
2x56	7x42	Shared	4.04067	3.79	1	1	2	1
2x57	7x39	Shared	6.20267	3.49	1	1	2	2
2x57	7x42	Shared	6.14467	4.79	1	1	2	1
3x32	7x42	Shared	7.51267	10.34	1	1	1	1
3x32	Lig	Shared	15.7673	18.04	1	1	1	0
3x33	4x57	Shared	3.71533	3.39	0	0	1	2
3x33	4x61	5ht2_off	3.60667	0	0	0	1	2
3x33	Lig	Shared	7.64467	15.14	0	0	1	0
3x36	Lig	Shared	10.842	5.87	0	1	1	0
3x37	5x461	Shared	4.73467	3.36	0	0	1	2
3x37	Lig	5ht2_off	3.838	0	0	0	1	0
4x60	5x39	5ht2_off	4.33267	0	0	0	2	1
4x61	5x39	Shared	4.34267	3.93	0	0	2	1
E2	E2	Shared	30.3533	68.13	1	2	2	2
5x36	E2	Shared	12.584	5.54	1	2	2	2
E2	E2x51	Shared	6.09533	1.59	1	2	2	1
5x36	5x39	5ht2_off	6.76467	0	1	2	2	1
5x40	6x55	Shared	4.872	7.01	0	0	2	1
5x44	6x52	Shared	4.84	3.96	0	0	2	1
5x47	5x48	Shared	6.28933	9.65	1	1	1	2
5x47	6x52	Shared	27.148	18.22	1	1	1	1
6x44	6x48	5ht2_off	8.75333	0	0	0	2	1
6x48	6x51	5ht2_off	6.68267	0	1	1	1	1
6x48	6x52	Shared	5.81267	8.02	1	1	1	1
6x48	7x41	Shared	12.2	8.44	1	1	1	2
6x48	Lig	5ht2_off	10.186	0	1	1	1	0
6x51	6x52	Shared	7.71667	5.36	1	1	1	1
6x51	6x55	5ht2_off	6.524	0	1	1	1	1
6x51	7x34	Shared	4.79	4.87	1	1	1	2
6x51	7x38	Shared	4.62867	3.93	1	1	1	1
6x51	Lig	Shared	12.1447	15.23	1	1	1	0
6x52	Lig	5ht2_off	11.9027	0	1	1	1	0
6x55	7x34	5ht2_off	4.94333	0	1	0	1	2
7x38	7x42	Shared	4.71067	6.31	1	1	1	1
7x38	Lig	Shared	7.194	4.66	1	1	1	0
7x39	7x42	Shared	10.032	3.86	1	1	2	1
7x42	Lig	5ht2_off	4.136	0	1	1	1	0
E2x51	Lig	5ht2_off	5.006	0	1	0	1	0
5x47	Lig	5ht2_off	3.57533	0	1	1	1	0
3x37	4x56	Shared	2.33067	3.04	0	0	1	2
5x43	Lig	5ht2_off	1.248	0	0	0	1	0
3x32	3x36	5ht2_on	0	4.42	1	1	1	1
3x37	4x53	5ht2_on	0	6.4	0	0	1	2
5x39	5x43	5ht2_on	0	3.01	0	0	1	1
5x39	Lig	5ht2_on	0	2.86	0	0	1	0
5x47	5x51	5ht2_on	0	3.65	1	1	1	2
5x47	6x44	5ht2_on	0	3.22	1	1	1	2
5x47	6x48	5ht2_on	0	3.01	1	1	1	1
5x47	6x49	5ht2_on	0	4.19	1	1	1	2
6x55	Lig	5ht2_on	0	2.15	1	0	1	0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	5ht2_off	5ht2a_off 5ht2b_off 5ht2c_off
	5ht2_on	5ht2b_on

Network Difference
Value	5ht2_off	5ht2_on
I_min	3.44133	2.86
Number of Linked Nodes	274	237
Number of Specific Nodes	37 (13.50%)	0 (0.00%)
Number of Shared Nodes	237 (86.50%)	237 (100.00%)
Number of Links	302	246
Number of Specific Links	151 (50.00%)	95 (38.62%)
Number of Shared Links	151 (50.00%)	151 (61.38%)
Number of Hubs	36	21
Number of Specific Hubs	20 (55.56%)	5 (23.81%)
Number of Shared Hubs	16 (44.44%)	16 (76.19%)
Average % Shared Neighbours (Jaccard)	39.88
Average % Shared Neighbours (Otsuka)	48.49
Average % Shared Neighbours (Overlap Coefficient)	56.97
Average % Shared Cliques (k3-6)	54.46
Graphlets Similarity	0.577133

Paths Difference
Value	5ht2_off	5ht2_on
Number Of Nodes in MetaPath	50	64
Specific Nodes in MetaPath	25 (50.00%)	39 (60.94%)
Shared Nodes in MetaPath	237 (86.50%)	237 (86.50%)
Number Of Links MetaPath	50	64
Specific Links in MetaPath	43 (86.00%)	57 (89.06%)
Shared Links in MetaPath	151 (50.00%)	151 (50.00%)
Number of Shortest Paths	41686	27005
Length Of Smallest Path	3	3
Average Path Length	10.8116	18.2785
Length of Longest Path	22	44
Minimum Path Strength	0.613	1.3
Average Path Strength	5.67349	5.76053
Maximum Path Strength	17.4323	16.635
Minimum Path Correlation	0.702667	0.7
Average Path Correlation	0.915166	0.928529
Maximum Path Correlation	0.988667	0.99
Minimum % Of Corr. Nodes	5.88235	2.7027
Average % Of Corr. Nodes	51.5717	52.6367
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	44.9202	27.8116
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 5ht2_off_on.zip<

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