psnGPCR

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Orange: nodes, hubs and links specific of 5ht2a_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of 5ht2a_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	5ht2a_off Int. Strength	5ht2a_on Int. Strength	5ht2a_off Hub1?	5ht2a_on Hub1?	5ht2a_off Hub2?	5ht2a_on Hub2?	ConSurf1	ConSurf2
1	1x42	7x43	5ht2a_off	100	0	No	No	No	No	7	4
2	1x49	7x50	5ht2a_off	100	0	No	No	No	No	8	9
3	1x53	7x50	5ht2a_off	100	0	No	No	No	No	9	9
4	1x53	7x53	5ht2a_off	100	0	No	No	Yes	Yes	9	9
5	1x54	2x44	5ht2a_off	100	0	No	No	No	No	6	5
6	1x60	8x56	5ht2a_off	100	0	Yes	No	No	No	6	4
7	1x60	8x57	5ht2a_off	100	0	Yes	No	Yes	No	6	4
8	8x49	I1x49	5ht2a_off	100	0	No	No	No	No	6	6
9	2x40	I1x50	5ht2a_off	100	0	No	No	Yes	No	9	8
10	4x39	I1x51	5ht2a_off	100	0	Yes	No	No	No	4	7
11	2x37	2x40	5ht2a_off	100	0	No	No	No	No	7	9
12	2x39	3x50	5ht2a_off	100	0	No	No	Yes	No	8	9
13	2x41	4x39	5ht2a_off	100	0	Yes	No	Yes	No	4	4
14	2x41	4x43	5ht2a_off	100	0	Yes	No	No	No	4	4
15	2x43	7x53	5ht2a_off	100	0	No	No	Yes	Yes	8	9
16	2x45	4x50	5ht2a_off	100	0	No	No	Yes	No	9	9
17	2x46	3x39	5ht2a_off	100	0	No	No	No	No	9	9
18	2x50	3x39	5ht2a_off	100	0	Yes	No	No	No	9	9
19	2x50	7x49	5ht2a_off	100	0	Yes	No	No	Yes	9	9
20	2x57	7x39	5ht2a_off	100	0	Yes	Yes	Yes	Yes	8	6
21	2x57	7x42	5ht2a_off	100	0	Yes	Yes	Yes	Yes	8	7
22	2x62	E1x51	5ht2a_off	100	0	No	No	No	No	4	3
23	2x64	E1.Y139	5ht2a_off	100	0	No	No	No	No	5	3
24	3x28	E1x50	5ht2a_off	100	0	Yes	Yes	Yes	Yes	5	7
25	E1x50	E2.F222	5ht2a_off	100	0	Yes	Yes	Yes	No	7	2
26	3x25	E2.F222	5ht2a_off	100	0	Yes	No	Yes	No	9	2
27	3x28	E2x50	5ht2a_off	100	0	Yes	Yes	No	No	5	9
28	3x29	4x61	5ht2a_off	100	0	No	No	No	No	5	6
29	3x30	3x34	5ht2a_off	100	0	No	Yes	Yes	No	6	6
30	3x33	4x57	5ht2a_off	100	0	No	No	No	No	6	7
31	3x33	4x61	5ht2a_off	100	0	No	No	No	No	6	6
32	3x35	4x50	5ht2a_off	100	0	Yes	Yes	Yes	No	7	9
33	3x39	6x44	5ht2a_off	100	0	No	No	Yes	No	9	9
34	3x40	6x44	5ht2a_off	100	0	No	No	Yes	No	8	9
35	3x41	5x50	5ht2a_off	100	0	No	No	No	No	6	9
36	3x43	6x44	5ht2a_off	100	0	No	No	Yes	No	8	9
37	3x44	5x53	5ht2a_off	100	0	No	No	No	No	6	6
38	3x54	5x64	5ht2a_off	100	0	No	No	No	No	9	6
39	3x54	5x68	5ht2a_off	100	0	No	No	No	No	9	7
40	I2x52	I2x53	5ht2a_off	100	0	No	No	Yes	No	5	7
41	4x39	4x43	5ht2a_off	100	0	Yes	No	No	No	4	4
42	4x63	4x64	5ht2a_off	100	0	No	No	No	No	5	4
43	4x64	E2.K220	5ht2a_off	100	0	No	No	No	No	4	3
44	5x37	E3.K350	5ht2a_off	100	0	No	No	No	No	4	1
45	5x51	6x45	5ht2a_off	100	0	No	No	No	No	6	6
46	5x65	6x31	5ht2a_off	100	0	No	Yes	No	No	8	5
47	5x68	6x27	5ht2a_off	100	0	No	No	No	No	7	5
48	6x25	6x29	5ht2a_off	100	0	No	No	No	No	5	6
49	6x31	6x35	5ht2a_off	100	0	No	No	No	No	5	7
50	6x38	6x41	5ht2a_off	100	0	No	No	Yes	No	6	8
51	6x39	7x56	5ht2a_off	100	0	No	No	No	No	6	7
52	6x40	7x49	5ht2a_off	100	0	No	No	No	Yes	8	9
53	6x44	7x45	5ht2a_off	100	0	Yes	No	No	No	9	9
54	6x44	Lig	5ht2a_off	100	0	Yes	No	Yes	Yes	9	0
55	6x48	6x51	5ht2a_off	100	0	Yes	Yes	Yes	No	8	7
56	6x48	7x42	5ht2a_off	100	0	Yes	Yes	Yes	Yes	8	7
57	6x51	6x55	5ht2a_off	100	0	Yes	No	No	No	7	7
58	6x51	7x38	5ht2a_off	100	0	Yes	No	No	No	7	6
59	6x55	7x34	5ht2a_off	100	0	No	No	Yes	No	7	3
60	6x61	E3.C353	5ht2a_off	100	0	No	No	No	No	3	3
61	E3.E351	E3.K350	5ht2a_off	100	0	No	No	No	No	5	1
62	7x53	8x50	5ht2a_off	100	0	Yes	Yes	Yes	Yes	9	8
63	7x55	7x56	5ht2a_off	100	0	No	No	No	No	5	7
64	8x47	8x49	5ht2a_off	100	0	No	No	No	No	9	6
65	8x50	8x54	5ht2a_off	100	0	Yes	Yes	No	No	8	6
66	8x53	8x57	5ht2a_off	100	0	No	No	Yes	No	7	4
67	8x59	CT.Q398	5ht2a_off	100	0	No	No	No	No	4	4
68	8x60	CT.Y399	5ht2a_off	100	0	No	No	No	No	8	2
69	3x43	6x41	5ht2a_off	100	0	No	No	Yes	No	8	8
70	3x47	6x41	5ht2a_off	100	0	No	No	Yes	No	9	8
71	3x50	6x30	5ht2a_off	100	0	Yes	No	No	No	9	8
72	4x39	I2x56	5ht2a_off	100	0	Yes	No	No	No	4	4
73	5x47	Lig	5ht2a_off	100	0	No	Yes	Yes	Yes	8	0
74	6x37	6x41	5ht2a_off	100	0	No	No	Yes	No	8	8
75	1x60	CT.E401	5ht2a_off	100	0	Yes	No	No	No	6	4
76	CT.E401	I1x48	5ht2a_off	100	0	No	No	No	No	4	6
77	E2x51	Lig	5ht2a_off	100	0	No	No	Yes	Yes	4	0
78	6x30	I2x53	5ht2a_off	33.3333	0	No	No	Yes	No	8	7
79	8x57	CT.Y399	5ht2a_off	66.6667	0	Yes	No	No	No	4	2
80	2x41	4x42	5ht2a_off	66.6667	0	Yes	No	No	No	4	7
81	7x36	7x37	5ht2a_off	50	0	No	No	Yes	No	4	5
82	5x39	E2x52	5ht2a_off	50	0	Yes	Yes	No	No	7	4
83	6x43	7x48	5ht2a_off	16.6667	0	No	No	No	No	6	6
84	1x54	2x51	5ht2a_off	16.6667	0	No	No	No	No	6	7
85	5x58	6x34	5ht2a_off	50	0	No	No	No	No	9	7
86	8x56	CT.Q398	5ht2a_off	33.3333	0	No	No	No	No	4	4
87	2x551	3x35	5ht2a_off	33.3333	0	No	No	Yes	Yes	5	7
88	1x41	1x45	5ht2a_off	0	0	No	No	No	No	4	4
89	1x36	2x65	5ht2a_off	16.6667	0	No	No	No	No	6	5
90	1x42	7x39	5ht2a_off	50	0	No	No	Yes	Yes	7	6
91	1x43	2x58	5ht2a_off	33.3333	0	No	No	No	No	6	8
92	6x47	7x48	5ht2a_off	16.6667	0	No	Yes	No	No	8	6
93	5x63	5x66	5ht2a_off	66.6667	0	No	No	No	No	4	6
94	3x22	E2.F222	5ht2a_off	16.6667	0	No	No	Yes	No	3	2
95	6x39	6x43	5ht2a_off	0	0	No	No	No	No	6	6
96	4x56	5x461	5ht2a_off	16.6667	0	No	No	No	No	6	6
97	1x32	1x33	5ht2a_off	33.3333	0	No	No	No	No	6	5
98	4x56	5x46	5ht2a_off	33.3333	0	No	No	No	No	6	4
99	7x37	7x40	5ht2a_off	33.3333	0	Yes	No	No	No	5	7
100	6x56	6x60	5ht2a_off	0	0	No	No	No	No	5	4
101	6x58	7x30	5ht2a_off	16.6667	0	No	No	No	No	4	4
102	E2.A230	E2.K223	5ht2a_off	50	0	No	No	Yes	No	3	3
103	4x60	5x39	5ht2a_off	16.6667	0	No	No	Yes	Yes	7	7
104	4x38	I2x53	5ht2a_off	16.6667	0	No	No	Yes	No	7	7
105	6x26	I2x53	5ht2a_off	33.3333	0	No	No	Yes	No	5	7
106	6x39	7x52	5ht2a_off	16.6667	0	No	No	No	No	6	8
107	6x61	E3.S352	5ht2a_off	16.6667	0	No	No	No	No	3	2
108	5x62	5x66	5ht2a_off	50	0	No	No	No	No	5	6
109	1x28	1x32	5ht2a_off	16.6667	0	No	No	No	No	3	6
110	5x69	6x27	5ht2a_off	16.6667	0	No	No	No	No	5	5
111	7x54	8x51	5ht2a_off	33.3333	0	No	Yes	No	No	7	9
112	1x36	2x61	5ht2a_off	16.6667	0	No	No	No	No	6	6
113	3x50	6x33	5ht2a_off	33.3333	0	Yes	No	No	No	9	8
114	1x29	1x33	5ht2a_off	16.6667	0	No	No	No	No	3	5
115	1x28	1x31	5ht2a_off	33.3333	0	No	No	No	No	3	3
116	1x58	2x44	5ht2a_off	16.6667	0	No	No	No	No	1	5
117	7x30	E3.C353	5ht2a_off	0	0	No	No	No	No	4	3
118	7x30	7x34	5ht2a_off	0	0	No	No	Yes	No	4	3
119	3x56	I2x51	5ht2a_off	33.3333	0	Yes	No	No	No	6	7
120	1x40	2x61	5ht2a_off	0	0	No	No	No	No	3	6
121	5x43	5x461	5ht2a_off	33.3333	0	No	No	No	No	6	6
122	5x42	5x46	5ht2a_off	0	0	No	No	No	No	4	4
123	1x27	1x30	5ht2a_off	33.3333	0	No	No	No	No	2	1
124	I2x54	I2x56	5ht2a_off	33.3333	0	No	No	No	No	6	4
125	I2x54	I2x57	5ht2a_off	16.6667	0	No	No	No	No	6	6
126	1x28	2x66	5ht2a_off	16.6667	0	No	No	No	No	3	4
127	6x45	6x49	5ht2a_off	0	0	No	No	No	No	6	6
128	7x27	E2.K223	5ht2a_off	33.3333	0	No	No	Yes	No	3	3
129	1x45	7x47	5ht2a_off	0	0	No	No	No	No	4	6
130	5x55	5x59	5ht2a_off	0	0	No	No	No	No	5	1
131	3x27	3x31	5ht2a_off	0	0	No	No	No	No	4	5
132	6x57	6x60	5ht2a_off	0	0	No	No	No	No	4	4
133	1x30	1x32	5ht2a_off	16.6667	0	No	No	No	No	1	6
134	1x35	2x64	5ht2a_off	0	0	No	No	No	No	3	5
135	3x52	3x56	5ht2a_off	16.6667	0	No	No	Yes	No	5	6
136	6x32	8x48	5ht2a_off	16.6667	0	No	No	No	No	8	5
137	3x53	3x56	5ht2a_off	16.6667	0	No	No	Yes	No	8	6
138	1x34	1x37	5ht2a_off	0	0	No	No	No	No	4	4
139	8x55	8x59	5ht2a_off	0	0	No	No	No	No	3	4
140	CT.K400	CT.Q398	5ht2a_off	16.6667	0	No	No	No	No	3	4
141	6x42	6x43	5ht2a_off	0	0	No	No	No	No	5	6
142	4x55	4x59	5ht2a_off	0	0	No	No	No	No	4	4
143	6x28	6x32	5ht2a_off	0	0	No	No	No	No	6	8
144	6x24	I3.T311	5ht2a_off	0	0	No	No	No	No	0	0
145	1x33	1x34	5ht2a_off	0	0	No	No	No	No	5	4
146	1x38	1x42	5ht2a_off	0	0	No	No	No	No	4	7
147	6x24	6x27	5ht2a_off	0	0	No	No	No	No	0	5
148	6x25	6x28	5ht2a_off	0	0	No	No	No	No	5	6
149	1x39	2x61	Shared	100	100	No	No	No	No	6	6
150	1x39	7x39	Shared	100	100	No	No	Yes	Yes	6	6
151	1x43	2x57	Shared	100	100	No	No	Yes	Yes	6	8
152	1x46	2x57	Shared	100	100	No	No	Yes	Yes	7	8
153	1x47	2x55	Shared	100	100	No	No	No	No	5	4
154	1x50	2x47	Shared	100	0	No	Yes	No	No	9	9
155	1x50	2x50	Shared	100	100	No	Yes	Yes	No	9	9
156	1x50	7x50	Shared	100	100	No	Yes	No	No	9	9
157	1x51	2x51	Shared	100	100	No	No	No	No	3	7
158	1x52	8x54	Shared	100	100	No	No	No	No	6	6
159	1x54	2x48	Shared	100	100	No	No	No	No	6	6
160	1x55	8x57	Shared	100	100	No	No	Yes	No	4	4
161	1x57	2x44	Shared	100	100	No	No	No	No	7	5
162	1x57	8x50	Shared	100	100	No	No	Yes	Yes	7	8
163	1x59	8x57	Shared	100	50	No	No	Yes	No	5	4
164	1x60	I1x50	Shared	100	100	Yes	No	Yes	No	6	8
165	I1x48	I1x51	Shared	100	0	No	No	No	No	6	7
166	8x49	I1x50	Shared	100	100	No	No	Yes	No	6	8
167	8x50	I1x50	Shared	100	100	Yes	Yes	Yes	No	8	8
168	2x41	I1x51	Shared	100	100	Yes	No	No	No	4	7
169	2x40	8x50	Shared	100	100	No	No	Yes	Yes	9	8
170	2x42	3x46	Shared	100	100	Yes	Yes	No	No	8	9
171	2x42	4x45	Shared	100	100	Yes	Yes	No	No	8	6
172	2x42	4x46	Shared	100	100	Yes	Yes	No	No	8	8
173	2x45	3x42	Shared	100	100	No	No	No	Yes	9	8
174	2x45	4x46	Shared	100	100	No	No	No	No	9	8
175	2x50	7x46	Shared	100	100	Yes	No	No	No	9	9
176	2x52	3x35	Shared	100	100	No	No	Yes	Yes	7	7
177	2x53	2x56	Shared	100	100	No	Yes	No	Yes	7	8
178	2x53	3x35	Shared	100	100	No	Yes	Yes	Yes	7	7
179	2x54	2x57	Shared	100	100	No	No	Yes	Yes	6	8
180	2x56	3x28	Shared	100	100	No	Yes	Yes	Yes	8	5
181	2x56	3x32	Shared	100	100	No	Yes	No	Yes	8	8
182	2x59	3x28	Shared	100	100	No	No	Yes	Yes	4	5
183	2x60	7x39	Shared	100	100	No	No	Yes	Yes	7	6
184	2x60	7x42	Shared	100	100	No	No	Yes	Yes	7	7
185	2x66	E1x49	Shared	100	100	No	No	No	No	4	4
186	2x66	E1x51	Shared	100	100	No	No	No	No	4	3
187	7x35	E1.Y139	Shared	100	100	No	No	No	No	4	3
188	E1x50	E1x51	Shared	100	0	Yes	Yes	No	No	7	3
189	E1x50	E1x52	Shared	100	100	Yes	Yes	No	No	7	5
190	3x25	E1x50	Shared	100	100	Yes	No	Yes	Yes	9	7
191	E1x50	E2x50	Shared	100	100	Yes	Yes	No	No	7	9
192	3x21	E1x52	Shared	100	100	No	No	No	No	7	5
193	3x21	3x24	Shared	100	100	No	No	No	No	7	5
194	3x25	E2.V221	Shared	100	100	Yes	No	No	No	9	3
195	3x25	E2x50	Shared	100	100	Yes	No	No	No	9	9
196	3x26	E2.V221	Shared	100	50	No	No	No	No	6	3
197	3x29	E2x52	Shared	100	100	No	No	No	No	5	4
198	3x30	4x62	Shared	100	100	No	Yes	No	No	6	5
199	3x32	7x42	Shared	100	100	No	Yes	Yes	Yes	8	7
200	3x32	Lig	Shared	100	100	No	Yes	Yes	Yes	8	0
201	3x33	Lig	Shared	100	100	No	No	Yes	Yes	6	0
202	3x34	3x35	Shared	100	100	Yes	No	Yes	Yes	6	7
203	3x34	4x54	Shared	100	50	Yes	No	No	No	6	4
204	3x34	4x57	Shared	100	100	Yes	No	No	No	6	7
205	3x36	Lig	Shared	100	100	No	No	Yes	Yes	7	0
206	3x37	4x53	Shared	100	100	No	Yes	No	No	7	8
207	3x37	5x461	Shared	100	100	No	Yes	No	No	7	6
208	3x38	4x50	Shared	100	100	No	No	Yes	No	8	9
209	3x40	5x50	Shared	100	100	No	No	No	No	8	9
210	3x42	4x49	Shared	100	100	No	Yes	No	No	8	6
211	3x42	4x50	Shared	100	100	No	Yes	Yes	No	8	9
212	3x47	5x57	Shared	100	100	No	No	No	No	9	5
213	3x48	5x57	Shared	100	50	No	No	No	No	6	5
214	3x49	4x45	Shared	100	100	No	No	No	No	9	6
215	3x51	3x55	Shared	100	100	Yes	Yes	No	No	8	6
216	3x51	5x60	Shared	100	100	Yes	Yes	No	No	8	5
217	3x51	5x61	Shared	100	100	Yes	Yes	No	No	8	9
218	3x54	5x65	Shared	100	100	No	No	No	Yes	9	8
219	3x55	5x64	Shared	100	100	No	No	No	No	6	6
220	3x56	I2x50	Shared	100	0	Yes	No	No	No	6	8
221	I2x55	I2x56	Shared	100	100	No	No	No	No	4	4
222	4x38	4x41	Shared	100	0	No	No	No	No	7	6
223	4x64	5x39	Shared	100	100	No	No	Yes	Yes	4	7
224	4x68	E2.S219	Shared	100	100	No	No	No	No	4	3
225	5x36	E2.K220	Shared	100	100	No	No	No	No	5	3
226	E2.K223	E2x51	Shared	100	100	Yes	No	No	No	3	4
227	5x36	5x38	Shared	100	100	No	No	No	No	5	3
228	5x36	5x39	Shared	100	100	No	No	Yes	Yes	5	7
229	5x37	6x59	Shared	100	100	No	No	No	Yes	4	5
230	5x40	6x55	Shared	100	100	No	No	No	No	6	7
231	5x41	6x59	Shared	100	50	No	No	No	Yes	6	5
232	5x44	6x52	Shared	100	100	No	No	Yes	Yes	6	7
233	5x44	6x56	Shared	100	100	No	No	No	No	6	5
234	5x45	5x48	Shared	100	100	No	No	No	No	4	5
235	5x47	5x48	Shared	100	100	No	Yes	No	No	8	5
236	5x47	6x52	Shared	100	100	No	Yes	Yes	Yes	8	7
237	5x49	5x50	Shared	100	100	No	No	No	No	5	9
238	5x54	6x41	Shared	100	100	No	No	Yes	No	8	8
239	5x58	5x62	Shared	100	100	No	No	No	No	9	5
240	5x58	6x38	Shared	100	100	No	No	No	No	9	6
241	5x65	6x30	Shared	100	50	No	Yes	No	No	8	8
242	6x42	6x46	Shared	100	0	No	No	No	No	5	5
243	6x44	6x48	Shared	100	100	Yes	No	Yes	Yes	9	8
244	6x47	7x45	Shared	100	100	No	Yes	No	No	8	9
245	6x48	7x41	Shared	100	100	Yes	Yes	No	No	8	7
246	6x48	Lig	Shared	100	100	Yes	Yes	Yes	Yes	8	0
247	6x50	7x37	Shared	100	100	No	No	Yes	No	9	5
248	6x51	6x52	Shared	100	100	Yes	No	Yes	Yes	7	7
249	6x51	7x34	Shared	100	50	Yes	No	Yes	No	7	3
250	6x51	Lig	Shared	100	100	Yes	No	Yes	Yes	7	0
251	6x52	Lig	Shared	100	100	Yes	Yes	Yes	Yes	7	0
252	6x54	7x34	Shared	100	100	No	No	Yes	No	5	3
253	6x54	7x37	Shared	100	100	No	No	Yes	No	5	5
254	7x26	7x28	Shared	100	100	No	No	No	No	1	2
255	7x26	7x29	Shared	100	100	No	No	No	No	1	5
256	7x33	7x37	Shared	100	100	No	No	Yes	No	4	5
257	7x38	7x42	Shared	100	100	No	No	Yes	Yes	6	7
258	7x38	Lig	Shared	100	100	No	No	Yes	Yes	6	0
259	7x39	7x42	Shared	100	100	Yes	Yes	Yes	Yes	6	7
260	7x51	7x55	Shared	100	100	No	No	No	No	6	5
261	7x54	8x54	Shared	100	50	No	Yes	No	No	7	6
262	8x47	8x50	Shared	100	100	No	No	Yes	Yes	9	8
263	4x68	E2.K220	Shared	100	100	No	No	No	No	4	3
264	7x49	7x53	Shared	100	100	No	Yes	Yes	Yes	9	9
265	5x59	5x63	Shared	100	0	No	No	No	No	1	4
266	3x38	4x53	Shared	33.3333	100	No	No	No	No	8	8
267	3x31	3x35	Shared	50	100	No	No	Yes	Yes	5	7
268	3x50	6x37	Shared	66.6667	100	Yes	No	No	No	9	8
269	3x23	E2.D218	Shared	50	100	No	No	No	No	1	3
270	E2.D218	E2.F222	Shared	33.3333	100	No	No	Yes	No	3	2
271	2x64	7x39	Shared	33.3333	50	No	No	Yes	Yes	5	6
272	2x42	3x45	Shared	50	50	Yes	Yes	No	No	8	7
273	E2.S226	E2x51	Shared	50	100	No	No	No	No	4	4
274	3x30	4x59	Shared	50	50	No	Yes	No	No	6	4
275	8x48	8x51	Shared	33.3333	100	No	No	No	No	5	9
276	5x56	5x60	Shared	0	0	No	No	No	No	5	5
277	6x36	7x56	Shared	33.3333	100	No	No	No	No	8	7
278	7x29	7x33	Shared	0	100	No	No	No	No	5	4
279	1x56	8x50	Shared	0	50	No	No	Yes	Yes	7	8
280	2x49	4x50	Shared	0	100	No	No	Yes	No	8	9
281	3x23	4x66	Shared	33.3333	100	No	No	No	No	1	5
282	3x41	4x52	Shared	33.3333	50	No	No	No	No	6	5
283	1x46	7x47	Shared	33.3333	100	No	No	No	No	7	6
284	2x51	2x55	Shared	50	100	No	No	No	No	7	4
285	2x63	E1x50	Shared	0	0	No	No	Yes	Yes	5	7
286	5x40	6x59	Shared	33.3333	50	No	No	No	Yes	6	5
287	3x48	5x53	Shared	50	50	No	No	No	No	6	6
288	4x65	E2.V221	Shared	16.6667	0	No	No	No	No	7	3
289	4x38	4x40	Shared	0	100	No	No	No	No	7	5
290	1x48	1x49	Shared	0	0	No	No	No	No	4	8
291	4x41	4x44	Shared	16.6667	100	No	No	No	No	6	3
292	6x49	6x50	Shared	0	100	No	No	No	No	6	9
293	8x48	8x52	Shared	16.6667	50	No	No	No	No	5	4
294	2x67	E1.Y139	Shared	0	100	No	No	No	No	5	3
295	5x52	5x56	Shared	0	50	No	No	No	No	3	5
296	2x38	4x42	Shared	0	0	No	No	No	No	5	7
297	7x31	7x34	Shared	16.6667	0	No	No	Yes	No	2	3
298	6x49	6x53	Shared	0	100	No	No	No	No	6	6
299	3x51	3x52	Shared	16.6667	0	Yes	Yes	No	No	8	5
300	4x47	4x51	Shared	0	0	No	No	No	No	2	4
301	4x51	4x52	Shared	0	50	No	No	No	No	4	5
302	1x52	8x58	Shared	16.6667	0	No	No	No	No	6	6
303	E2.E224	E2.K223	Shared	0	0	No	No	Yes	No	2	3
304	E2.F222	E2.G225	Shared	0	50	Yes	No	No	No	2	3
305	4x63	4x67	Shared	0	0	No	No	No	No	5	6
306	1x37	1x39	5ht2a_on	0	100	No	No	No	No	4	6
307	1x37	2x61	5ht2a_on	0	100	No	No	No	No	4	6
308	1x50	2x51	5ht2a_on	0	100	No	Yes	No	No	9	7
309	1x60	I1x49	5ht2a_on	0	100	Yes	No	No	No	6	6
310	2x42	3x42	5ht2a_on	0	100	Yes	Yes	No	Yes	8	8
311	2x43	7x54	5ht2a_on	0	100	No	No	No	Yes	8	7
312	2x46	3x42	5ht2a_on	0	100	No	No	No	Yes	9	8
313	2x50	7x50	5ht2a_on	0	100	Yes	No	No	No	9	9
314	2x53	2x54	5ht2a_on	0	100	No	Yes	No	No	7	6
315	2x53	3x32	5ht2a_on	0	100	No	Yes	No	Yes	7	8
316	2x53	7x46	5ht2a_on	0	100	No	Yes	No	No	7	9
317	2x551	3x31	5ht2a_on	0	100	No	No	No	No	5	5
318	2x60	3x28	5ht2a_on	0	100	No	No	Yes	Yes	7	5
319	2x61	2x65	5ht2a_on	0	100	No	No	No	No	6	5
320	2x64	7x35	5ht2a_on	0	100	No	No	No	No	5	4
321	3x24	E1x52	5ht2a_on	0	100	No	No	No	No	5	5
322	3x26	4x66	5ht2a_on	0	100	No	No	No	No	6	5
323	3x28	3x29	5ht2a_on	0	100	Yes	Yes	No	No	5	5
324	3x29	E2x50	5ht2a_on	0	100	No	No	No	No	5	9
325	3x30	4x57	5ht2a_on	0	100	No	Yes	No	No	6	7
326	3x37	3x41	5ht2a_on	0	100	No	Yes	No	No	7	6
327	3x40	6x48	5ht2a_on	0	100	No	No	Yes	Yes	8	8
328	3x43	7x49	5ht2a_on	0	100	No	No	No	Yes	8	9
329	3x43	7x53	5ht2a_on	0	100	No	No	Yes	Yes	8	9
330	3x44	5x50	5ht2a_on	0	100	No	No	No	No	6	9
331	3x50	7x53	5ht2a_on	0	100	Yes	No	Yes	Yes	9	9
332	3x51	5x57	5ht2a_on	0	100	Yes	Yes	No	No	8	5
333	3x53	I2x53	5ht2a_on	0	100	No	No	Yes	No	8	7
334	3x55	3x56	5ht2a_on	0	100	No	No	Yes	No	6	6
335	3x56	I2x52	5ht2a_on	0	100	Yes	No	No	No	6	5
336	I2x51	I2x55	5ht2a_on	0	100	No	No	No	No	7	4
337	4x39	I2x57	5ht2a_on	0	100	Yes	No	No	No	4	6
338	4x59	4x60	5ht2a_on	0	100	No	No	No	No	4	7
339	4x61	4x62	5ht2a_on	0	100	No	No	No	No	6	5
340	4x61	5x39	5ht2a_on	0	100	No	No	Yes	Yes	6	7
341	5x38	5x42	5ht2a_on	0	100	No	No	No	No	3	4
342	5x461	Lig	5ht2a_on	0	100	No	No	Yes	Yes	6	0
343	5x47	5x51	5ht2a_on	0	100	No	Yes	No	No	8	6
344	5x47	6x48	5ht2a_on	0	100	No	Yes	Yes	Yes	8	8
345	5x54	6x44	5ht2a_on	0	100	No	No	Yes	No	8	9
346	5x55	6x41	5ht2a_on	0	100	No	No	Yes	No	5	8
347	5x58	6x41	5ht2a_on	0	100	No	No	Yes	No	9	8
348	5x62	6x34	5ht2a_on	0	100	No	No	No	No	5	7
349	5x62	6x37	5ht2a_on	0	100	No	No	No	No	5	8
350	5x65	6x34	5ht2a_on	0	100	No	Yes	No	No	8	7
351	6x32	6x35	5ht2a_on	0	100	No	No	No	No	8	7
352	6x32	7x56	5ht2a_on	0	100	No	No	No	No	8	7
353	6x40	7x53	5ht2a_on	0	100	No	No	Yes	Yes	8	9
354	6x43	6x47	5ht2a_on	0	100	No	No	No	Yes	6	8
355	6x48	6x52	5ht2a_on	0	100	Yes	Yes	Yes	Yes	8	7
356	6x48	7x45	5ht2a_on	0	100	Yes	Yes	No	No	8	9
357	7x28	7x29	5ht2a_on	0	100	No	No	No	No	2	5
358	7x42	Lig	5ht2a_on	0	100	Yes	Yes	Yes	Yes	7	0
359	7x43	7x48	5ht2a_on	0	100	No	No	No	No	4	6
360	7x49	7x50	5ht2a_on	0	100	No	Yes	No	No	9	9
361	7x54	8x50	5ht2a_on	0	100	No	Yes	Yes	Yes	7	8
362	2x38	4x39	5ht2a_on	0	100	No	No	Yes	No	5	4
363	2x56	7x42	5ht2a_on	0	100	No	Yes	Yes	Yes	8	7
364	3x27	3x30	5ht2a_on	0	100	No	No	No	Yes	4	6
365	3x30	3x31	5ht2a_on	0	100	No	Yes	No	No	6	5
366	4x43	4x47	5ht2a_on	0	100	No	No	No	No	4	2
367	E2.K223	E2.S226	5ht2a_on	0	100	Yes	No	No	No	3	4
368	5x38	5x39	5ht2a_on	0	100	No	No	Yes	Yes	3	7
369	5x48	6x56	5ht2a_on	0	100	No	No	No	No	5	5
370	5x65	5x66	5ht2a_on	0	100	No	Yes	No	No	8	6
371	5x66	6x34	5ht2a_on	0	100	No	No	No	No	6	7
372	6x29	6x32	5ht2a_on	0	100	No	No	No	No	6	8
373	7x41	Lig	5ht2a_on	0	100	No	No	Yes	Yes	7	0
374	8x52	8x56	5ht2a_on	0	100	No	No	No	No	4	4
375	1x53	7x54	5ht2a_on	0	50	No	No	No	Yes	9	7
376	6x46	6x47	5ht2a_on	0	50	No	No	No	Yes	5	8
377	3x37	4x56	5ht2a_on	0	50	No	Yes	No	No	7	6
378	1x58	1x59	5ht2a_on	0	50	No	No	No	No	1	5
379	5x61	6x37	5ht2a_on	0	50	No	No	No	No	9	8
380	2x37	2x39	5ht2a_on	0	50	No	No	No	No	7	8
381	2x39	2x40	5ht2a_on	0	50	No	No	No	No	8	9
382	1x51	1x55	5ht2a_on	0	50	No	No	No	No	3	4
383	6x47	7x40	5ht2a_on	0	50	No	Yes	No	No	8	7
384	6x47	7x43	5ht2a_on	0	50	No	Yes	No	No	8	4
385	6x27	6x30	5ht2a_on	0	50	No	No	No	No	5	8
386	I2x51	I2x52	5ht2a_on	0	50	No	No	No	No	7	5
387	3x49	I2x53	5ht2a_on	0	50	No	No	Yes	No	9	7
388	5x42	5x43	5ht2a_on	0	0	No	No	No	No	4	6
389	2x57	2x58	5ht2a_on	0	0	Yes	Yes	No	No	8	8
390	1x54	2x47	5ht2a_on	0	50	No	No	No	No	6	9
391	6x36	6x40	5ht2a_on	0	0	No	No	No	No	8	8
392	6x40	7x52	5ht2a_on	0	0	No	No	No	No	8	8
393	1x42	1x46	5ht2a_on	0	0	No	No	No	No	7	7
394	5x65	6x33	5ht2a_on	0	0	No	Yes	No	No	8	8
395	2x37	2x38	5ht2a_on	0	0	No	No	No	No	7	5
396	6x26	6x27	5ht2a_on	0	50	No	No	No	No	5	5
397	5x69	6x30	5ht2a_on	0	50	No	No	No	No	5	8
398	3x39	7x49	5ht2a_on	0	0	No	No	No	Yes	9	9
399	5x40	E2x52	5ht2a_on	0	50	No	No	No	No	6	4
400	6x57	7x30	5ht2a_on	0	50	No	No	No	No	4	4
401	6x53	6x57	5ht2a_on	0	50	No	No	No	No	6	4
402	6x35	6x39	5ht2a_on	0	50	No	No	No	No	7	6
403	5x64	5x68	5ht2a_on	0	50	No	No	No	No	6	7
404	8x53	8x56	5ht2a_on	0	50	No	No	No	No	7	4
405	6x27	6x31	5ht2a_on	0	0	No	No	No	No	5	5
406	I2x54	I2x55	5ht2a_on	0	50	No	No	No	No	6	4
407	5x45	5x46	5ht2a_on	0	0	No	No	No	No	4	4
408	6x44	6x45	5ht2a_on	0	0	Yes	No	No	No	9	6
409	1x57	2x41	5ht2a_on	0	50	No	No	Yes	No	7	4
410	7x53	7x54	5ht2a_on	0	0	Yes	Yes	No	Yes	9	7
411	7x55	8x51	5ht2a_on	0	0	No	No	No	No	5	9
412	4x64	4x67	5ht2a_on	0	0	No	No	No	No	4	6
413	2x62	2x66	5ht2a_on	0	0	No	No	No	No	4	4
414	4x54	4x55	5ht2a_on	0	0	No	No	No	No	4	4
415	6x58	6x59	5ht2a_on	0	0	No	No	No	Yes	4	5
416	5x69	5x70	5ht2a_on	0	0	No	No	No	No	5	0
417	8x49	8x52	5ht2a_on	0	0	No	No	No	No	6	4
418	1x37	1x40	5ht2a_on	0	0	No	No	No	No	4	3
419	7x36	7x40	5ht2a_on	0	0	No	No	No	No	4	7
420	6x28	6x29	5ht2a_on	0	0	No	No	No	No	6	6
421	1x43	1x44	5ht2a_on	0	0	No	No	No	No	6	4
422	7x27	7x30	5ht2a_on	0	0	No	No	No	No	3	4
423	8x55	8x56	5ht2a_on	0	0	No	No	No	No	3	4
424	6x42	6x45	5ht2a_on	0	0	No	No	No	No	5	6
425	4x40	4x43	5ht2a_on	0	0	No	No	No	No	5	4
426	E1.Y139	E2.S226	5ht2a_on	0	0	No	No	No	No	3	4
427	5x59	5x60	5ht2a_on	0	0	No	No	No	No	1	5

Orange: nodes, hubs and links specific of 5ht2a_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of 5ht2a_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	5ht2a_off Avg Int. Strength	5ht2a_on Avg Int. Strength	5ht2a_off Num Of Links	5ht2a_on Num Of Links	ConSurf
1	1x60	5ht2a_off	33.3333	0	4	2	6
2	I1x50	5ht2a_off	33.3333	0	4	3	8
3	2x41	5ht2a_off	0	0	4	2	4
4	2x50	5ht2a_off	50	100	4	3	9
5	3x25	5ht2a_off	50	0	4	3	9
6	3x34	5ht2a_off	33.3333	0	4	3	6
7	3x50	5ht2a_off	50	0	4	2	9
8	3x56	5ht2a_off	0	0	4	3	6
9	I2x53	5ht2a_off	33.3333	0	4	2	7
10	4x39	5ht2a_off	0	0	4	2	4
11	4x50	5ht2a_off	50	50	5	3	9
12	E2.F222	5ht2a_off	0	0	5	2	2
13	E2.K223	5ht2a_off	0	0	4	3	3
14	6x41	5ht2a_off	83.3333	0	5	3	8
15	6x44	5ht2a_off	100	0	6	3	9
16	6x51	5ht2a_off	100	50	6	3	7
17	7x34	5ht2a_off	0	0	5	3	3
18	7x37	5ht2a_off	66.6667	0	5	3	5
19	8x57	5ht2a_off	83.3333	0	5	2	4
20	2x42	Shared	83.3333	100	4	5	8
21	2x57	Shared	100	0	5	4	8
22	E1x50	Shared	100	50	7	5	7
23	3x28	Shared	83.3333	100	4	4	5
24	3x35	Shared	83.3333	100	6	4	7
25	3x51	Shared	33.3333	100	4	5	8
26	5x39	Shared	16.6667	0	4	4	7
27	6x48	Shared	100	100	5	7	8
28	6x52	Shared	83.3333	100	4	5	7
29	7x39	Shared	100	0	6	4	6
30	7x42	Shared	100	100	6	6	7
31	7x53	Shared	50	50	4	5	9
32	8x50	Shared	100	100	7	6	8
33	Lig	Shared	100	100	10	10	0
34	1x50	5ht2a_on	0	0	3	4	9
35	2x53	5ht2a_on	0	100	2	5	7
36	2x56	5ht2a_on	33.3333	0	3	4	8
37	3x30	5ht2a_on	66.6667	0	3	5	6
38	3x32	5ht2a_on	16.6667	50	3	4	8
39	3x37	5ht2a_on	16.6667	50	2	4	7
40	3x42	5ht2a_on	100	100	3	5	8
41	5x47	5ht2a_on	33.3333	50	3	4	8
42	5x65	5ht2a_on	0	0	3	5	8
43	6x47	5ht2a_on	0	50	2	5	8
44	6x59	5ht2a_on	0	0	3	4	5
45	7x49	5ht2a_on	16.6667	0	3	4	9
46	7x54	5ht2a_on	0	50	2	5	7

Orange: nodes, hubs and links specific of 5ht2a_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of 5ht2a_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	5ht2a_off Recurrence	5ht2a_on Recurrence	5ht2a_off Hub1?	5ht2a_on Hub1?	5ht2a_off Hub2?	5ht2a_on Hub2?	ConSurf1	ConSurf2
1	6x48	7x42	5ht2a_off	24.3049	0	Yes	Yes	Yes	Yes	8	7
2	3x39	6x44	5ht2a_off	89.6305	0	No	No	Yes	No	9	9
3	2x50	3x39	5ht2a_off	87.6309	0	Yes	No	No	No	9	9
4	2x50	7x49	5ht2a_off	78.128	0	Yes	No	No	Yes	9	9
5	7x53	8x50	5ht2a_off	74.0764	0	Yes	Yes	Yes	Yes	9	8
6	1x57	2x44	5ht2a_off	12.8452	2.25809	No	No	No	No	7	5
7	8x50	8x54	5ht2a_off	17.2443	0	Yes	Yes	No	No	8	6
8	1x60	I1x50	5ht2a_off	36.2645	3.96185	Yes	No	Yes	No	6	8
9	1x60	CT.E401	5ht2a_off	19.1011	0	Yes	No	No	No	6	4
10	CT.E401	I1x48	5ht2a_off	17.7728	0	No	No	No	No	4	6
11	I1x48	I1x51	5ht2a_off	16.2302	2.01353	No	No	No	No	6	7
12	3x43	6x44	5ht2a_off	67.0491	0	No	No	Yes	No	8	9
13	3x43	6x41	5ht2a_off	65.8541	0	No	No	Yes	No	8	8
14	6x37	6x41	5ht2a_off	47.0339	0	No	No	Yes	No	8	8
15	3x35	4x50	5ht2a_off	41.6302	0	Yes	Yes	Yes	No	7	9
16	2x45	4x50	5ht2a_off	15.3399	0	No	No	Yes	No	9	9
17	2x45	4x46	5ht2a_off	13.1594	2.59232	No	No	No	No	9	8
18	2x42	4x46	5ht2a_off	10.9027	2.64123	Yes	Yes	No	No	8	8
19	3x28	E1x50	5ht2a_off	34.1316	0	Yes	Yes	Yes	Yes	5	7
20	3x33	Lig	5ht2a_off	53.2994	2.60047	No	No	Yes	Yes	6	0
21	3x33	4x61	5ht2a_off	24.4953	0	No	No	No	No	6	6
22	3x29	4x61	5ht2a_off	23.2765	0	No	No	No	No	5	6
23	3x34	3x35	5ht2a_off	25.8379	8.81226	Yes	No	Yes	Yes	6	7
24	3x33	4x57	5ht2a_off	32.4605	0	No	No	No	No	6	7
25	3x34	4x57	5ht2a_off	31.294	2.62493	Yes	No	No	No	6	7
26	3x40	6x44	5ht2a_off	11.3597	0	No	No	Yes	No	8	9
27	3x50	6x30	5ht2a_off	42.1015	0	Yes	No	No	No	9	8
28	3x54	5x65	5ht2a_off	27.5376	2.55971	No	No	No	Yes	9	8
29	3x54	5x64	5ht2a_off	18.9392	0	No	No	No	No	9	6
30	3x55	5x64	5ht2a_off	17.3919	4.01891	No	No	No	No	6	6
31	6x30	I2x53	5ht2a_off	10.6218	0	No	No	Yes	No	8	7
32	5x39	E2x52	5ht2a_off	20.5389	0	Yes	Yes	No	No	7	4
33	6x48	6x51	5ht2a_off	22.1053	0	Yes	Yes	Yes	No	8	7
34	6x51	6x55	5ht2a_off	14.4163	0	Yes	No	No	No	7	7
35	5x40	6x55	5ht2a_off	13.2546	3.18741	No	No	No	No	6	7
36	6x38	6x41	5ht2a_off	12.431	0	No	No	Yes	No	6	8
37	5x58	6x38	5ht2a_off	10.8408	2.63308	No	No	No	No	9	6
38	7x54	8x54	5ht2a_off	12.7547	5.93462	No	Yes	No	No	7	6
39	7x54	8x51	5ht2a_off	11.1645	0	No	Yes	No	No	7	9
40	6x44	7x45	5ht2a_off	18.9821	0	Yes	No	No	No	9	9
41	6x47	7x48	5ht2a_off	15.8779	0	No	Yes	No	No	8	6
42	6x43	7x48	5ht2a_off	14.3116	0	No	No	No	No	6	6
43	7x30	7x34	5ht2a_off	11.4454	0	No	No	Yes	No	4	3
44	1x28	2x66	5ht2a_off	11.0265	0	No	No	No	No	3	4
45	2x57	7x42	5ht2a_off	15.1543	0	Yes	Yes	Yes	Yes	8	7
46	6x44	Lig	5ht2a_off	100	0	Yes	No	Yes	Yes	9	0
47	7x39	7x42	Shared	25.6237	33.0806	Yes	Yes	Yes	Yes	6	7
48	6x44	6x48	Shared	34.6648	61.0581	Yes	No	Yes	Yes	9	8
49	7x49	7x53	Shared	75.8855	85.2939	No	Yes	Yes	Yes	9	9
50	1x57	8x50	Shared	14.2116	10.9888	No	No	Yes	Yes	7	8
51	8x50	I1x50	Shared	39.8543	26.6569	Yes	Yes	Yes	No	8	8
52	3x50	6x37	Shared	45.6342	42.2842	Yes	No	No	No	9	8
53	3x32	7x42	Shared	13.0261	12.1953	No	Yes	Yes	Yes	8	7
54	2x56	3x32	Shared	64.1354	22.6624	No	Yes	No	Yes	8	8
55	2x53	2x56	Shared	31.4083	40.9065	No	Yes	No	Yes	7	8
56	2x53	3x35	Shared	30.3656	53.9904	No	Yes	Yes	Yes	7	7
57	2x56	3x28	Shared	42.3062	71.7616	No	Yes	Yes	Yes	8	5
58	E1x50	E1x51	Shared	16.2683	14.5675	Yes	Yes	No	No	7	3
59	2x66	E1x51	Shared	13.6783	10.9481	No	No	No	No	4	3
60	3x32	Lig	Shared	60.9027	87.0873	No	Yes	Yes	Yes	8	0
61	3x29	E2x52	Shared	21.7673	23.4369	No	No	No	No	5	4
62	3x38	4x50	Shared	18.1632	36.5126	No	No	Yes	No	8	9
63	3x38	4x53	Shared	15.9255	38.8767	No	No	No	No	8	8
64	3x37	4x53	Shared	13.6783	41.2244	No	Yes	No	No	7	8
65	3x37	5x461	Shared	11.4216	65.9738	No	Yes	No	No	7	6
66	5x65	6x30	Shared	31.513	15.8637	No	Yes	No	No	8	8
67	3x51	3x55	Shared	15.8351	21.0483	Yes	Yes	No	No	8	6
68	5x40	6x59	Shared	11.4312	14.054	No	No	No	Yes	6	5
69	6x51	7x34	Shared	43.2584	40.4092	Yes	No	Yes	No	7	3
70	6x54	7x34	Shared	29.2563	35.2898	No	No	Yes	No	5	3
71	6x54	7x37	Shared	27.071	32.4366	No	No	Yes	No	5	5
72	6x50	7x37	Shared	11.4454	17.9343	No	No	Yes	No	9	5
73	6x47	7x45	Shared	17.4348	19.7848	No	Yes	No	No	8	9
74	6x51	Lig	Shared	33.9269	35.3387	Yes	No	Yes	Yes	7	0
75	1x39	7x39	5ht2a_on	9.87431	12.5622	No	No	Yes	Yes	6	6
76	2x53	3x32	5ht2a_on	0	76.7995	No	Yes	No	Yes	7	8
77	2x53	2x54	5ht2a_on	0	18.5131	No	Yes	No	No	7	6
78	2x54	2x57	5ht2a_on	1.99486	16.255	No	No	Yes	Yes	6	8
79	2x56	7x42	5ht2a_on	0	35.2735	No	Yes	Yes	Yes	8	7
80	2x53	7x46	5ht2a_on	0	100	No	Yes	No	No	7	9
81	2x50	7x46	5ht2a_on	1.64731	99.3071	Yes	No	No	No	9	9
82	1x50	2x50	5ht2a_on	8.64121	17.062	No	Yes	Yes	No	9	9
83	1x50	2x51	5ht2a_on	0	16.6544	No	Yes	No	No	9	7
84	2x50	7x50	5ht2a_on	0	81.5603	Yes	No	No	No	9	9
85	1x51	2x51	5ht2a_on	1.65207	10.1247	No	No	No	No	3	7
86	7x49	7x50	5ht2a_on	0	88.7666	No	Yes	No	No	9	9
87	7x53	7x54	5ht2a_on	0	66.7074	Yes	Yes	No	Yes	9	7
88	7x54	8x50	5ht2a_on	0	56.1017	No	Yes	Yes	Yes	7	8
89	8x49	I1x50	5ht2a_on	3.39459	21.0973	No	No	Yes	No	6	8
90	7x42	Lig	5ht2a_on	0	58.7593	Yes	Yes	Yes	Yes	7	0
91	5x461	Lig	5ht2a_on	0	68.1259	No	No	Yes	Yes	6	0
92	3x42	4x50	5ht2a_on	4.52771	31.7356	No	Yes	Yes	No	8	9
93	2x42	3x42	5ht2a_on	0	19.4343	Yes	Yes	No	Yes	8	8
94	3x31	3x35	5ht2a_on	4.59436	41.2896	No	No	Yes	Yes	5	7
95	2x60	3x28	5ht2a_on	0	26.0129	No	No	Yes	Yes	7	5
96	3x28	3x29	5ht2a_on	0	90.1687	Yes	Yes	No	No	5	5
97	3x29	E2x50	5ht2a_on	0	65.4928	No	No	No	No	5	9
98	E1x50	E2x50	5ht2a_on	0.109503	30.7655	Yes	Yes	No	No	7	9
99	2x64	7x39	5ht2a_on	9.02685	21.3418	No	No	Yes	Yes	5	6
100	2x64	7x35	5ht2a_on	0	18.9859	No	No	No	No	5	4
101	7x35	E1.Y139	5ht2a_on	1.69492	16.6707	No	No	No	No	4	3
102	3x25	E2x50	5ht2a_on	5.12759	31.76	Yes	No	No	No	9	9
103	3x25	E2.V221	5ht2a_on	7.99372	28.8661	Yes	No	No	No	9	3
104	3x26	E2.V221	5ht2a_on	2.67092	21.7576	No	No	No	No	6	3
105	3x26	4x66	5ht2a_on	0	18.1707	No	No	No	No	6	5
106	3x23	4x66	5ht2a_on	1.40449	14.5675	No	No	No	No	1	5
107	3x23	E2.D218	5ht2a_on	2.80423	10.9481	No	No	No	No	1	3
108	3x30	3x31	5ht2a_on	0	37.1403	No	Yes	No	No	6	5
109	3x30	4x62	5ht2a_on	1.74729	29.1351	No	Yes	No	No	6	5
110	3x37	3x41	5ht2a_on	0	22.8825	No	Yes	No	No	7	6
111	6x48	Lig	5ht2a_on	5.69891	77.6392	Yes	Yes	Yes	Yes	8	0
112	3x40	6x48	5ht2a_on	0	12.0567	No	No	Yes	Yes	8	8
113	5x54	6x44	5ht2a_on	0	58.0664	No	No	Yes	No	8	9
114	5x54	6x41	5ht2a_on	1.64731	56.7865	No	No	Yes	No	8	8
115	5x58	6x41	5ht2a_on	0	54.3572	No	No	Yes	No	9	8
116	5x58	5x62	5ht2a_on	8.16035	52.0991	No	No	No	No	9	5
117	5x62	6x37	5ht2a_on	0	41.7625	No	No	No	No	5	8
118	5x61	6x37	5ht2a_on	0	44.6075	No	No	No	No	9	8
119	3x51	5x61	5ht2a_on	1.64731	42.7488	Yes	Yes	No	No	8	9
120	3x51	5x60	5ht2a_on	4.92287	10.9155	Yes	Yes	No	No	8	5
121	5x62	6x34	5ht2a_on	0	29.4041	No	No	No	No	5	7
122	5x65	6x34	5ht2a_on	0	24.0401	No	Yes	No	No	8	7
123	3x55	3x56	5ht2a_on	0	15.1708	No	No	Yes	No	6	6
124	3x56	I2x52	5ht2a_on	0	10.9155	Yes	No	No	No	6	5
125	3x41	4x52	5ht2a_on	4.92287	20.4043	No	No	No	No	6	5
126	4x51	4x52	5ht2a_on	3.28985	17.9098	No	No	No	No	4	5
127	4x47	4x51	5ht2a_on	1.64731	15.399	No	No	No	No	2	4
128	4x43	4x47	5ht2a_on	0	12.8719	No	No	No	No	4	2
129	4x40	4x43	5ht2a_on	0	10.3285	No	No	No	No	5	4
130	4x61	4x62	5ht2a_on	0	26.9585	No	No	No	No	6	5
131	4x61	5x39	5ht2a_on	0	24.7575	No	No	Yes	Yes	6	7
132	E1.Y139	E2.S226	5ht2a_on	0	11.0214	No	No	No	No	3	4
133	5x40	E2x52	5ht2a_on	0	20.3147	No	No	No	No	6	4
134	6x52	Lig	5ht2a_on	7.8985	15.2768	Yes	Yes	Yes	Yes	7	0
135	5x47	6x52	5ht2a_on	0.457056	10.1981	No	Yes	Yes	Yes	8	7
136	5x47	5x48	5ht2a_on	3.74691	14.7713	No	Yes	No	No	8	5
137	5x47	6x48	5ht2a_on	0	14.054	No	Yes	Yes	Yes	8	8
138	6x40	7x53	5ht2a_on	0	20.7141	No	No	Yes	Yes	8	9
139	6x36	6x40	5ht2a_on	0	16.524	No	No	No	No	8	8
140	6x36	7x56	5ht2a_on	1.64254	14.2007	No	No	No	No	8	7
141	6x32	7x56	5ht2a_on	0	11.8855	No	No	No	No	8	7
142	6x48	7x45	5ht2a_on	0	22.695	Yes	Yes	No	No	8	9
143	6x49	6x50	5ht2a_on	9.17444	14.9833	No	No	No	No	6	9
144	7x33	7x37	5ht2a_on	9.17444	12.0078	No	No	Yes	No	4	5
145	8x49	8x52	5ht2a_on	0	18.8392	No	No	No	No	6	4
146	2x40	8x50	5ht2a_on	2.80899	15.3664	No	No	Yes	Yes	9	8
147	2x39	2x40	5ht2a_on	0	13.4263	No	No	No	No	8	9
148	2x37	2x39	5ht2a_on	0	11.0948	No	No	No	No	7	8
149	6x49	6x53	5ht2a_on	2.30432	12.016	No	No	No	No	6	6
150	3x50	7x53	5ht2a_on	0	42.651	Yes	No	Yes	Yes	9	9
151	2x60	7x42	5ht2a_on	1.68539	24.4314	No	No	Yes	Yes	7	7

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
2x53	2x56	Shared	5.46333	5.96	0	1	2	2
2x56	3x32	Shared	8.76333	7.3	0	1	2	1
2x57	7x39	5ht2a_off	5.04167	0	1	0	2	2
2x57	7x42	5ht2a_off	10.9767	0	1	0	2	1
2x60	7x39	Shared	6.795	3.705	1	1	2	2
2x60	7x42	Shared	4.875	2.545	1	1	2	1
3x32	7x42	Shared	9.00333	7.47	0	1	1	1
3x32	Lig	Shared	14.9517	12.24	0	1	1	0
3x33	4x57	5ht2a_off	4.04167	0	0	0	1	2
3x33	4x61	5ht2a_off	4.61	0	0	0	1	2
3x33	Lig	Shared	4.705	5.375	0	0	1	0
3x36	Lig	Shared	11.05	13.795	0	0	1	0
3x37	5x461	Shared	6.13	4	0	0	2	1
3x39	6x44	5ht2a_off	9.52833	0	0	0	2	1
3x40	6x44	5ht2a_off	6.49	0	0	0	2	1
3x43	6x44	5ht2a_off	4.87	0	0	3	2	1
E2.K223	E2x51	Shared	5.64	7.05	0	6	2	1
5x44	6x52	Shared	5.50167	3.965	0	0	2	1
5x47	5x48	Shared	4.64333	4.825	1	1	1	2
5x47	6x52	Shared	18.2183	15.54	1	1	1	1
5x51	6x45	5ht2a_off	4.25667	0	0	0	2	2
6x44	6x48	Shared	9.18667	5.51	1	0	1	1
6x44	7x45	5ht2a_off	5.75167	0	1	0	1	2
6x44	Lig	5ht2a_off	4.16333	0	1	0	1	0
6x48	6x51	5ht2a_off	7.35167	0	1	1	1	1
6x48	7x41	Shared	12.67	2.815	1	1	1	1
6x48	7x42	5ht2a_off	3.53667	0	1	1	1	1
6x48	Lig	Shared	18.5533	4.305	1	1	1	0
6x51	6x52	Shared	5.18	8.575	1	1	1	1
6x51	6x55	5ht2a_off	6.645	0	1	1	1	2
6x51	7x34	Shared	4.06167	2.44	1	1	1	2
6x51	7x38	5ht2a_off	4.80333	0	1	1	1	1
6x51	Lig	Shared	10.3117	12.705	1	1	1	0
6x52	Lig	Shared	17.415	18.46	1	1	1	0
6x55	7x34	5ht2a_off	6.40833	0	1	0	2	2
7x38	7x42	Shared	8.20333	5.68	1	1	1	1
7x38	Lig	Shared	4.69167	2.94	1	1	1	0
7x39	7x42	Shared	15.1133	8.685	1	1	2	1
5x47	Lig	5ht2a_off	6.49333	0	1	1	1	0
E2x51	Lig	5ht2a_off	4.755	0	0	6	1	0
E2.S226	E2x51	Shared	3.00167	5.255	0	6	2	1
4x56	5x461	5ht2a_off	2.58167	0	0	0	2	1
5x43	5x461	5ht2a_off	1.85667	0	0	0	2	1
2x53	3x32	5ht2a_on	0	2.715	0	1	2	1
3x40	6x48	5ht2a_on	0	5.285	0	0	2	1
5x461	Lig	5ht2a_on	0	4.445	0	0	1	0
5x47	5x51	5ht2a_on	0	3.045	1	1	1	2
5x47	6x48	5ht2a_on	0	3.51	1	1	1	1
5x54	6x44	5ht2a_on	0	6.84	0	0	2	1
6x48	6x52	5ht2a_on	0	3.01	1	1	1	1
6x48	7x45	5ht2a_on	0	4.325	1	1	1	2
7x42	Lig	5ht2a_on	0	4.585	1	1	1	0
2x56	7x42	5ht2a_on	0	2.525	0	1	2	1
E2.K223	E2.S226	5ht2a_on	0	5.355	0	6	2	2
7x41	Lig	5ht2a_on	0	4.845	0	1	1	0
3x37	4x56	5ht2a_on	0	2.28	0	0	2	2
6x44	6x45	5ht2a_on	0	1.31	1	0	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	5ht2a_off	6A94-5-HT_2A-Zotepine 6WH4-5-HT_2A-Methiothepin 7VOE-5-HT_2A-Aripiprazole 7VOD-5-HT_2A-Cariprazine 7WC8-5-HT_2A-Lumateperone 6A93-5-HT_2A-Risperidone
	5ht2a_on	7RAN-5-HT_2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 6WHA-5-HT_2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2

Network Difference
Value	5ht2a_off	5ht2a_on
I_min	3.50833	2.455
Number of Linked Nodes	285	257
Number of Specific Nodes	30 (10.53%)	2 (0.78%)
Number of Shared Nodes	255 (89.47%)	255 (99.22%)
Number of Links	305	279
Number of Specific Links	148 (48.52%)	122 (43.73%)
Number of Shared Links	157 (51.48%)	157 (56.27%)
Number of Hubs	33	27
Number of Specific Hubs	19 (57.58%)	13 (48.15%)
Number of Shared Hubs	14 (42.42%)	14 (51.85%)
Average % Shared Neighbours (Jaccard)	40.07
Average % Shared Neighbours (Otsuka)	48.80
Average % Shared Neighbours (Overlap Coefficient)	57.83
Average % Shared Cliques (k3-6)	77.50
Graphlets Similarity	0.551185

Paths Difference
Value	5ht2a_off	5ht2a_on
Number Of Nodes in MetaPath	72	100
Specific Nodes in MetaPath	23 (31.94%)	51 (51.00%)
Shared Nodes in MetaPath	255 (89.47%)	255 (89.47%)
Number Of Links MetaPath	74	105
Specific Links in MetaPath	46 (62.16%)	77 (73.33%)
Shared Links in MetaPath	157 (51.48%)	157 (51.48%)
Number of Shortest Paths	53362	41428
Length Of Smallest Path	3	3
Average Path Length	12.9023	13.1141
Length of Longest Path	28	28
Minimum Path Strength	0.375	0.615
Average Path Strength	6.09278	4.76679
Maximum Path Strength	17.9842	17
Minimum Path Correlation	0.701667	0.7
Average Path Correlation	0.915578	0.917388
Maximum Path Correlation	0.99	0.985
Minimum % Of Corr. Nodes	4	4.34783
Average % Of Corr. Nodes	46.7668	44.2317
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	41.1241	37.5399
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

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