psnGPCR

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Orange: nodes, hubs and links specific of 5ht2b_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of 5ht2b_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	5ht2b_off Int. Strength	5ht2b_on Int. Strength	5ht2b_off Hub1?	5ht2b_on Hub1?	5ht2b_off Hub2?	5ht2b_on Hub2?	ConSurf1	ConSurf2
1	3x37	Lig	5ht2b_off	5.56	0	No	No	Yes	Yes	7	0
2	E2x51	Lig	5ht2b_off	3.37	0	No	No	Yes	Yes	3	0
3	E2x52	Lig	5ht2b_off	5.22	0	No	No	Yes	Yes	5	0
4	6x52	Lig	5ht2b_off	11.94	0	Yes	Yes	Yes	Yes	7	0
5	7x42	Lig	5ht2b_off	3.54	0	Yes	Yes	Yes	Yes	8	0
6	NT.I39	NT.P40	5ht2b_off	3.39	0	No	No	No	No	5	9
7	NT.E41	NT.I39	5ht2b_off	9.56	0	No	No	No	No	7	5
8	NT.E42	NT.I39	5ht2b_off	13.66	0	No	No	No	No	6	5
9	NT.E42	NT.Q45	5ht2b_off	5.1	0	No	No	No	No	6	5
10	NT.K44	NT.V47	5ht2b_off	10.62	0	No	No	No	No	4	3
11	NT.E48	NT.K44	5ht2b_off	10.8	0	No	No	No	No	3	4
12	NT.E49	NT.I46	5ht2b_off	5.47	0	No	No	No	No	4	4
13	E1.E118	NT.Q50	5ht2b_off	14.02	0	No	No	No	No	4	2
14	1x33	NT.N52	5ht2b_off	4.12	0	No	No	No	No	4	3
15	1x32	1x35	5ht2b_off	6.96	0	No	No	No	No	1	4
16	1x34	1x35	5ht2b_off	13.75	0	No	No	No	No	4	4
17	1x39	2x61	5ht2b_off	4.15	0	No	No	No	No	5	6
18	1x39	7x39	5ht2b_off	25.06	0	No	No	Yes	Yes	5	7
19	1x49	7x51	5ht2b_off	5.13	0	No	No	No	No	8	6
20	1x52	8x57	5ht2b_off	3.52	0	No	No	Yes	No	7	5
21	1x54	2x48	5ht2b_off	3.07	0	No	No	No	No	7	6
22	1x59	8x57	5ht2b_off	8.21	0	No	No	Yes	No	4	5
23	1x60	I1x48	5ht2b_off	4.05	0	Yes	No	Yes	No	7	7
24	1x60	I1x49	5ht2b_off	18.9	0	Yes	No	No	No	7	6
25	1x60	I1x50	5ht2b_off	6.63	0	Yes	No	Yes	No	7	8
26	I1x48	I1x49	5ht2b_off	12.93	0	Yes	No	No	No	7	6
27	2x40	I1x50	5ht2b_off	4.12	0	Yes	No	Yes	No	9	8
28	2x41	2x44	5ht2b_off	8.38	0	Yes	No	No	No	5	7
29	2x41	4x43	5ht2b_off	10.32	0	Yes	No	No	No	5	4
30	2x41	4x46	5ht2b_off	3.63	0	Yes	No	No	No	5	7
31	2x42	3x46	5ht2b_off	3.77	0	Yes	No	No	No	8	9
32	2x42	4x46	5ht2b_off	3.77	0	Yes	No	No	No	8	7
33	2x42	4x49	5ht2b_off	3.93	0	Yes	No	No	No	8	7
34	2x46	7x50	5ht2b_off	3.28	0	No	No	Yes	No	9	9
35	2x48	2x52	5ht2b_off	2.98	0	No	No	No	No	6	7
36	2x50	7x50	5ht2b_off	8.05	0	Yes	Yes	Yes	No	9	9
37	2x51	2x55	5ht2b_off	6.92	0	Yes	No	No	No	7	5
38	2x53	2x56	5ht2b_off	3.21	0	No	No	No	No	7	7
39	2x53	2x57	5ht2b_off	3.04	0	No	No	Yes	Yes	7	8
40	2x57	2x58	5ht2b_off	3.35	0	Yes	Yes	No	No	8	9
41	2x59	E1x50	5ht2b_off	3.52	0	No	No	Yes	Yes	5	7
42	2x59	E1x52	5ht2b_off	4.28	0	No	No	Yes	Yes	5	6
43	2x61	7x39	5ht2b_off	4.56	0	No	No	Yes	Yes	6	7
44	2x66	E1x51	5ht2b_off	5.78	0	No	No	No	No	3	3
45	E1x49	E1x51	5ht2b_off	3.35	0	No	No	No	No	3	3
46	3x24	E1x52	5ht2b_off	6.92	0	No	No	Yes	Yes	5	6
47	3x25	E2.I195	5ht2b_off	4.91	0	Yes	No	No	No	9	5
48	3x25	E2.I205	5ht2b_off	3.27	0	Yes	No	No	No	9	2
49	3x28	3x29	5ht2b_off	5.69	0	Yes	No	No	No	6	5
50	3x30	4x59	5ht2b_off	3.77	0	No	No	Yes	No	6	4
51	3x34	4x50	5ht2b_off	3.42	0	Yes	No	Yes	Yes	6	9
52	3x34	4x57	5ht2b_off	3.15	0	Yes	No	No	No	6	8
53	3x35	4x50	5ht2b_off	4.01	0	Yes	Yes	Yes	Yes	6	9
54	3x39	7x46	5ht2b_off	6.52	0	No	No	No	No	9	9
55	3x43	6x41	5ht2b_off	12.18	0	No	No	Yes	No	9	8
56	3x43	6x44	5ht2b_off	10.96	0	No	No	Yes	No	9	9
57	3x44	5x50	5ht2b_off	3.77	0	No	No	Yes	No	7	9
58	3x46	6x41	5ht2b_off	5.02	0	No	No	Yes	No	9	8
59	3x47	5x54	5ht2b_off	6.13	0	No	No	Yes	No	9	8
60	3x47	6x41	5ht2b_off	7.93	0	No	No	Yes	No	9	8
61	3x48	3x52	5ht2b_off	3.07	0	No	No	No	No	6	5
62	3x54	6x30	5ht2b_off	5.47	0	No	No	No	No	9	8
63	4x50	4x53	5ht2b_off	4.94	0	Yes	Yes	No	No	9	8
64	4x59	4x62	5ht2b_off	3.39	0	Yes	No	No	No	4	7
65	4x59	4x63	5ht2b_off	5.89	0	Yes	No	No	No	4	6
66	4x60	5x39	5ht2b_off	7.22	0	No	No	Yes	No	8	7
67	4x64	5x36	5ht2b_off	8.69	0	No	No	Yes	No	4	5
68	E2.D198	E2.D200	5ht2b_off	10.65	0	No	No	No	No	4	4
69	E2.D198	E2.N201	5ht2b_off	6.73	0	No	No	Yes	Yes	4	2
70	E2.E212	E2.T210	5ht2b_off	7.06	0	No	No	No	No	5	5
71	5x36	5x39	5ht2b_off	4.29	0	Yes	No	Yes	No	5	7
72	5x41	6x56	5ht2b_off	4.28	0	No	No	No	No	5	6
73	5x44	6x55	5ht2b_off	4.47	0	No	No	No	No	7	6
74	5x51	5x55	5ht2b_off	4.28	0	No	No	No	No	6	5
75	5x54	6x45	5ht2b_off	7.07	0	Yes	No	No	No	8	5
76	5x65	6x34	5ht2b_off	3	0	No	No	No	No	8	7
77	6x25	6x29	5ht2b_off	5.28	0	No	No	No	No	5	7
78	6x26	6x30	5ht2b_off	4.23	0	No	No	No	No	5	8
79	6x28	6x29	5ht2b_off	2.98	0	No	No	No	No	4	7
80	6x35	6x39	5ht2b_off	10.18	0	No	No	No	No	7	7
81	6x37	6x38	5ht2b_off	3.42	0	Yes	No	No	No	8	5
82	6x37	6x41	5ht2b_off	9.74	0	Yes	No	Yes	No	8	8
83	6x37	7x53	5ht2b_off	7.03	0	Yes	No	No	Yes	8	9
84	6x41	7x53	5ht2b_off	3.09	0	Yes	No	No	Yes	8	9
85	6x44	6x45	5ht2b_off	3.65	0	Yes	No	No	No	9	5
86	6x44	6x48	5ht2b_off	7.02	0	Yes	No	Yes	No	9	8
87	6x44	7x45	5ht2b_off	5.28	0	Yes	No	No	No	9	9
88	6x44	7x46	5ht2b_off	3.96	0	Yes	No	No	No	9	9
89	6x44	7x49	5ht2b_off	9.67	0	Yes	No	No	No	9	9
90	6x48	6x51	5ht2b_off	6.01	0	Yes	No	Yes	Yes	8	7
91	6x48	7x45	5ht2b_off	4.94	0	Yes	No	No	No	8	9
92	6x48	7x46	5ht2b_off	8.65	0	Yes	No	No	No	8	9
93	6x51	6x55	5ht2b_off	6.04	0	Yes	Yes	No	No	7	6
94	7x29	7x32	5ht2b_off	3.01	0	No	No	No	No	5	2
95	7x31	7x34	5ht2b_off	5.32	0	No	No	No	No	2	5
96	7x31	7x35	5ht2b_off	8.92	0	No	No	No	No	2	5
97	7x33	7x37	5ht2b_off	4.87	0	No	No	Yes	No	5	5
98	7x38	7x39	5ht2b_off	3.68	0	No	No	Yes	Yes	6	7
99	7x49	7x50	5ht2b_off	6.52	0	No	No	Yes	No	9	9
100	7x51	8x54	5ht2b_off	3.65	0	No	No	Yes	No	6	7
101	7x54	8x54	5ht2b_off	5.19	0	Yes	No	Yes	No	7	7
102	8x47	8x50	5ht2b_off	8.46	0	No	No	Yes	Yes	9	9
103	8x50	8x54	5ht2b_off	4.29	0	Yes	Yes	Yes	No	9	7
104	8x53	8x57	5ht2b_off	4	0	No	No	Yes	No	7	5
105	8x55	8x58	5ht2b_off	3.53	0	No	No	No	Yes	5	6
106	8x57	CT.Y399	5ht2b_off	2.98	0	Yes	No	No	No	5	4
107	CT.N398	CT.T396	5ht2b_off	8.77	0	No	No	No	No	6	4
108	1x57	2x40	5ht2b_off	2.96	0	No	No	Yes	No	8	9
109	2x43	7x54	5ht2b_off	2.95	0	No	No	Yes	No	8	7
110	4x47	4x51	5ht2b_off	2.95	0	No	No	No	No	3	4
111	5x61	5x65	5ht2b_off	2.95	0	No	No	No	No	9	8
112	6x54	7x30	5ht2b_off	2.95	0	No	No	No	No	5	4
113	1x40	1x44	5ht2b_off	2.94	0	No	No	No	No	7	4
114	2x39	2x40	5ht2b_off	2.92	0	No	No	Yes	No	8	9
115	5x40	E2.K211	5ht2b_off	2.88	0	No	No	Yes	Yes	6	5
116	1x33	2x65	5ht2b_off	2.83	0	No	No	No	No	4	5
117	3x50	6x33	5ht2b_off	2.77	0	No	No	No	No	9	8
118	8x48	8x52	5ht2b_off	2.77	0	No	No	No	No	5	5
119	3x51	5x64	5ht2b_off	2.67	0	Yes	No	No	No	8	6
120	6x40	6x41	5ht2b_off	2.62	0	No	No	Yes	No	8	8
121	6x40	7x56	5ht2b_off	2.62	0	No	No	No	No	8	7
122	2x60	3x28	5ht2b_off	2.59	0	No	No	Yes	No	7	6
123	7x36	7x37	5ht2b_off	2.51	0	No	No	Yes	No	4	5
124	CT.R400	I1x48	5ht2b_off	2.48	0	No	No	Yes	No	4	7
125	5x38	5x39	5ht2b_off	2.39	0	No	No	Yes	No	2	7
126	1x55	8x57	5ht2b_off	2.34	0	No	No	Yes	No	4	5
127	1x60	8x56	5ht2b_off	2.33	0	Yes	No	No	No	7	6
128	1x35	1x38	5ht2b_off	2.28	0	No	No	No	No	4	5
129	5x37	6x59	5ht2b_off	1.84	0	No	No	No	No	4	5
130	1x45	7x48	5ht2b_off	1.77	0	No	No	No	No	4	6
131	4x56	5x43	5ht2b_off	1.76	0	No	No	No	No	6	6
132	4x65	E2.I195	5ht2b_off	1.76	0	No	No	No	No	6	5
133	NT.M43	NT.P40	5ht2b_off	1.68	0	No	No	No	No	5	9
134	5x69	6x27	5ht2b_off	1.62	0	No	No	No	No	5	4
135	1x36	2x65	5ht2b_off	1.61	0	No	No	No	No	3	5
136	4x38	4x41	5ht2b_off	1.6	0	No	No	No	No	8	7
137	3x48	5x57	5ht2b_off	1.59	0	No	No	No	No	6	6
138	3x24	3x27	5ht2b_off	1.58	0	No	No	No	No	5	4
139	I2x53	I2x57	5ht2b_off	1.56	0	No	No	No	No	8	7
140	NT.I46	NT.V47	5ht2b_off	1.54	0	No	No	No	No	4	3
141	4x44	4x48	5ht2b_off	1.54	0	No	No	No	No	4	3
142	NT.M43	NT.V47	5ht2b_off	1.52	0	No	No	No	No	5	3
143	1x411	1x42	5ht2b_off	1.52	0	No	No	No	No	4	7
144	6x35	6x36	5ht2b_off	1.52	0	No	No	No	No	7	8
145	8x58	CT.T396	5ht2b_off	1.52	0	No	Yes	No	No	6	4
146	4x41	4x45	5ht2b_off	1.5	0	No	No	No	No	7	6
147	E2.D200	E2.V199	5ht2b_off	1.46	0	No	No	No	No	4	3
148	1x38	1x411	5ht2b_off	1.41	0	No	No	No	No	5	4
149	1x41	1x411	5ht2b_off	1.41	0	No	No	No	No	3	4
150	6x43	6x46	5ht2b_off	1.38	0	No	No	No	No	5	5
151	E2.N201	E2.N204	5ht2b_off	1.36	0	Yes	Yes	Yes	No	2	3
152	CT.C397	CT.Y399	5ht2b_off	1.34	0	No	No	No	No	8	4
153	3x50	3x54	5ht2b_off	1.25	0	No	No	No	No	9	9
154	5x42	5x45	5ht2b_off	1.22	0	No	No	No	No	4	4
155	6x42	6x43	5ht2b_off	1.22	0	No	No	No	No	6	5
156	3x32	Lig	Shared	15.35	18.04	Yes	Yes	Yes	Yes	8	0
157	3x33	Lig	Shared	12.36	15.14	No	No	Yes	Yes	7	0
158	3x36	Lig	Shared	7.93	5.87	No	No	Yes	Yes	7	0
159	5x39	Lig	Shared	5.51	2.86	Yes	No	Yes	Yes	7	0
160	6x51	Lig	Shared	16.54	15.23	Yes	Yes	Yes	Yes	7	0
161	7x38	Lig	Shared	3.37	4.66	No	No	Yes	Yes	6	0
162	1x42	2x57	Shared	3.04	3.04	No	No	Yes	Yes	7	8
163	1x42	7x43	Shared	8.02	3.21	No	No	No	No	7	5
164	1x43	2x57	Shared	5.83	5.83	No	No	Yes	Yes	6	8
165	1x44	1x45	Shared	3.39	3.39	No	No	No	No	4	4
166	1x46	7x47	Shared	5.46	3.64	No	No	No	No	8	7
167	1x47	2x51	Shared	4.28	2.85	No	No	Yes	No	7	7
168	1x47	2x55	Shared	5.71	2.85	No	No	No	No	7	5
169	1x50	2x50	Shared	5.39	4.04	Yes	Yes	Yes	Yes	9	9
170	1x50	2x51	Shared	5.49	6.87	Yes	Yes	Yes	No	9	7
171	1x50	7x50	Shared	4.89	9.77	Yes	Yes	Yes	No	9	9
172	1x52	8x54	Shared	7.31	6.09	No	No	Yes	No	7	7
173	1x53	2x47	Shared	3.39	1.7	No	No	No	No	9	9
174	1x53	7x54	Shared	4.76	4.76	No	No	Yes	No	9	7
175	1x56	8x54	Shared	4.16	2.77	No	No	Yes	No	8	7
176	1x57	2x44	Shared	6.09	6.09	No	No	No	No	8	7
177	8x49	I1x50	Shared	5.9	5.9	No	No	Yes	No	7	8
178	8x50	I1x50	Shared	13.4	14.61	Yes	Yes	Yes	No	9	8
179	2x37	2x40	Shared	16.28	15.12	No	No	Yes	No	7	9
180	2x38	I2x57	Shared	4.69	4.69	No	No	No	No	6	7
181	2x40	8x50	Shared	3.62	6.04	Yes	No	Yes	Yes	9	9
182	2x41	4x39	Shared	4.12	13.38	Yes	No	No	Yes	5	4
183	2x42	3x42	Shared	7.92	5.66	Yes	No	Yes	Yes	8	8
184	2x42	4x45	Shared	3.72	3.72	Yes	No	No	No	8	6
185	2x45	3x42	Shared	8.37	8.37	No	No	Yes	Yes	9	8
186	2x45	4x46	Shared	9.29	9.29	No	No	No	No	9	7
187	2x45	4x50	Shared	6.18	6.18	No	No	Yes	Yes	9	9
188	2x46	2x50	Shared	5.43	4.07	No	No	Yes	Yes	9	9
189	2x46	3x42	Shared	9	9	No	No	Yes	Yes	9	8
190	2x50	3x39	Shared	4.42	5.89	Yes	Yes	No	No	9	9
191	2x52	3x35	Shared	13.4	9.74	No	No	Yes	Yes	7	6
192	2x53	3x35	Shared	3.93	3.93	No	No	Yes	Yes	7	6
193	2x54	2x57	Shared	3.49	3.49	No	No	Yes	Yes	6	8
194	2x55	2x551	Shared	3.65	6.09	No	No	No	No	5	5
195	2x56	3x32	Shared	5.84	2.92	No	No	Yes	Yes	7	8
196	2x56	7x42	Shared	3.79	3.79	No	No	Yes	Yes	7	8
197	2x57	7x39	Shared	4.65	3.49	Yes	Yes	Yes	Yes	8	7
198	2x57	7x42	Shared	3.59	4.79	Yes	Yes	Yes	Yes	8	8
199	2x59	3x28	Shared	15.27	7.05	No	No	Yes	No	5	6
200	2x64	7x39	Shared	4.7	3.52	No	No	Yes	Yes	5	7
201	2x65	2x66	Shared	3.73	3.73	No	No	No	No	5	3
202	E1x50	E1x51	Shared	5.4	5.4	Yes	Yes	No	No	7	3
203	E1x50	E1x52	Shared	9.11	4.56	Yes	Yes	Yes	Yes	7	6
204	3x25	E1x50	Shared	6.53	5.22	Yes	No	Yes	Yes	9	7
205	3x28	E1x50	Shared	7.5	4.69	Yes	No	Yes	Yes	6	7
206	E1x50	E2x50	Shared	16.98	10.45	Yes	Yes	No	No	7	9
207	3x21	E1x52	Shared	4.93	4.93	No	No	Yes	Yes	7	6
208	3x22	E2.I205	Shared	7.14	2.85	No	No	No	No	4	2
209	3x23	3x24	Shared	2.98	2.98	No	No	No	No	3	5
210	3x25	3x26	Shared	3.77	3.77	Yes	No	No	No	9	7
211	3x25	E2x50	Shared	7.28	7.28	Yes	No	No	No	9	9
212	3x29	4x61	Shared	2.98	4.47	No	No	No	No	5	6
213	3x30	4x62	Shared	11.56	13	No	No	No	No	6	7
214	3x31	3x35	Shared	6.09	3.65	No	No	Yes	Yes	5	6
215	3x32	3x36	Shared	4.42	4.42	Yes	Yes	No	No	8	7
216	3x32	7x42	Shared	6.9	10.34	Yes	Yes	Yes	Yes	8	8
217	3x33	4x57	Shared	3.39	3.39	No	No	No	No	7	8
218	3x34	3x35	Shared	6.09	3.65	Yes	No	Yes	Yes	6	6
219	3x34	4x53	Shared	4.5	3	Yes	No	No	No	6	8
220	3x37	4x56	Shared	4.56	3.04	No	No	No	No	7	6
221	3x38	4x50	Shared	5.19	3.89	No	No	Yes	Yes	8	9
222	3x38	4x53	Shared	3.42	3.42	No	No	No	No	8	8
223	3x40	5x50	Shared	3.39	3.39	No	No	Yes	No	8	9
224	3x41	4x52	Shared	10.57	10.57	No	No	No	No	6	5
225	3x41	5x50	Shared	9.46	8.11	No	No	Yes	No	6	9
226	3x42	4x49	Shared	6.92	5.54	Yes	Yes	No	No	8	7
227	3x42	4x50	Shared	6.35	4.23	Yes	Yes	Yes	Yes	8	9
228	3x43	7x49	Shared	10.98	4.12	No	No	No	No	9	9
229	3x44	5x53	Shared	4.91	3.27	No	No	No	No	7	8
230	3x44	5x54	Shared	4.86	4.86	No	No	Yes	No	7	8
231	3x49	4x45	Shared	12.44	12.44	No	No	No	No	9	6
232	3x50	6x37	Shared	3.64	4.86	No	No	Yes	No	9	8
233	3x51	3x55	Shared	3.58	7.17	Yes	No	No	No	8	7
234	3x51	5x60	Shared	12.89	1.17	Yes	No	No	No	8	6
235	3x51	5x61	Shared	6.24	6.24	Yes	No	No	No	8	9
236	3x54	5x65	Shared	5.71	7.14	No	No	No	No	9	8
237	3x55	3x56	Shared	5.75	1.44	No	No	No	No	7	6
238	4x39	4x43	Shared	6.41	2.14	No	Yes	No	No	4	4
239	4x48	4x52	Shared	3.07	1.54	No	No	No	No	3	5
240	4x56	5x46	Shared	3.25	1.62	No	No	No	No	6	4
241	4x59	4x60	Shared	5.08	5.08	Yes	No	No	No	4	8
242	4x61	4x62	Shared	3.53	3.53	No	No	No	No	6	7
243	4x61	5x39	Shared	5.24	3.93	No	No	Yes	No	6	7
244	4x64	E2.R213	Shared	6.19	3.71	No	No	No	Yes	4	3
245	E2.E196	E2.R213	Shared	3.49	11.63	No	No	No	Yes	5	3
246	E2.N203	E2.N204	Shared	4.09	1.36	No	No	Yes	No	4	3
247	E2.N204	E2.T206	Shared	4.39	4.39	Yes	No	No	No	3	4
248	5x36	E2x52	Shared	6.09	12.18	Yes	No	No	No	5	5
249	E2.K211	E3.D351	Shared	4.15	2.77	Yes	Yes	No	No	5	3
250	7x27	E2.K211	Shared	12.2	2.71	No	No	Yes	Yes	3	5
251	5x36	E2.R213	Shared	11.76	4.28	Yes	No	No	Yes	5	3
252	5x40	6x55	Shared	8.41	7.01	No	No	No	No	6	6
253	5x40	6x59	Shared	3.04	3.04	No	No	No	No	6	5
254	5x41	5x42	Shared	7.31	8.53	No	No	No	No	5	4
255	5x41	6x60	Shared	4.15	2.77	No	No	No	No	5	5
256	5x44	6x52	Shared	5.28	3.96	No	No	Yes	Yes	7	7
257	5x44	6x56	Shared	4.64	3.1	No	No	No	No	7	6
258	5x47	5x48	Shared	10.72	9.65	Yes	Yes	No	No	8	6
259	5x47	6x48	Shared	4.01	3.01	Yes	Yes	Yes	No	8	8
260	5x47	6x52	Shared	24.65	18.22	Yes	Yes	Yes	Yes	8	7
261	5x49	5x50	Shared	5.25	5.25	No	No	Yes	No	5	9
262	5x51	6x45	Shared	4.15	4.15	No	No	No	No	6	5
263	5x54	6x41	Shared	3.73	3.73	Yes	No	Yes	No	8	8
264	5x56	5x60	Shared	2.98	2.98	No	No	No	No	4	6
265	5x58	5x59	Shared	9.28	8.25	No	Yes	No	No	9	3
266	5x58	5x62	Shared	8.46	12.09	No	Yes	No	No	9	5
267	5x68	6x30	Shared	12.15	4.05	No	No	No	No	7	8
268	6x29	6x32	Shared	3.62	10.85	No	No	No	No	7	8
269	6x47	7x45	Shared	10.73	4.6	No	No	No	No	8	9
270	6x48	6x52	Shared	8.02	8.02	Yes	No	Yes	Yes	8	7
271	6x48	7x41	Shared	11.26	8.44	Yes	No	No	No	8	7
272	6x50	7x37	Shared	10.11	7.22	No	No	Yes	No	9	5
273	6x51	6x52	Shared	9.65	5.36	Yes	Yes	Yes	Yes	7	7
274	6x51	7x34	Shared	4.87	4.87	Yes	Yes	No	No	7	5
275	6x51	7x38	Shared	3.93	3.93	Yes	Yes	No	No	7	6
276	6x54	7x34	Shared	5.9	7.37	No	No	No	No	5	5
277	6x54	7x37	Shared	5.19	2.59	No	No	Yes	No	5	5
278	6x58	7x30	Shared	8.3	2.77	No	No	No	No	4	4
279	6x59	6x60	Shared	2.98	2.98	No	No	No	No	5	5
280	6x61	E3.C353	Shared	7.28	7.28	No	No	No	No	5	4
281	7x26	7x29	Shared	4.39	5.85	No	No	No	No	4	5
282	7x32	7x35	Shared	4.06	2.71	No	No	No	No	2	5
283	7x39	7x42	Shared	6.75	3.86	Yes	Yes	Yes	Yes	7	8
284	7x51	7x55	Shared	5.54	2.77	No	No	No	No	6	6
285	7x54	8x50	Shared	11.67	9.08	Yes	No	Yes	Yes	7	9
286	1x51	2x51	Shared	2.95	2.95	No	No	Yes	No	4	7
287	1x46	1x50	Shared	2.92	2.92	No	No	Yes	Yes	8	9
288	6x47	7x40	Shared	2.92	2.92	No	No	No	No	8	8
289	7x26	7x28	Shared	2.92	5.85	No	No	No	No	4	2
290	1x40	2x61	Shared	2.85	5.71	No	No	No	No	7	6
291	1x52	8x58	Shared	2.85	4.28	No	No	No	Yes	7	6
292	3x34	4x54	Shared	2.85	2.85	Yes	No	No	No	6	4
293	5x47	6x49	Shared	2.79	4.19	Yes	Yes	No	No	8	6
294	2x42	3x45	Shared	2.77	2.77	Yes	No	No	No	8	7
295	5x62	5x66	Shared	2.74	4.12	No	No	No	No	5	6
296	3x56	I2x52	Shared	2.71	6.78	No	No	No	No	6	5
297	E2.E212	E2.K211	Shared	2.7	2.7	No	No	Yes	Yes	5	5
298	2x49	4x50	Shared	2.59	2.59	No	No	Yes	Yes	8	9
299	2x60	7x39	Shared	2.59	3.89	No	No	Yes	Yes	7	7
300	5x55	5x59	Shared	2.51	2.51	No	No	No	No	5	3
301	8x48	8x51	Shared	2.48	6.19	No	No	No	No	5	9
302	2x62	2x66	Shared	2.44	1.22	No	No	No	No	5	3
303	2x63	E1x50	Shared	2.43	2.43	No	No	Yes	Yes	5	7
304	1x48	1x49	Shared	2.11	2.11	No	No	No	No	4	8
305	3x37	5x461	Shared	1.82	3.36	No	No	No	No	7	7
306	4x54	4x55	Shared	1.76	1.76	No	No	No	No	4	5
307	6x61	E3.S352	Shared	1.72	3.44	No	No	No	No	5	4
308	3x56	I2x50	Shared	1.67	1.67	No	No	No	No	6	8
309	6x49	6x53	Shared	1.64	1.64	No	No	No	No	6	6
310	E2.N201	E2.P202	Shared	1.63	1.63	Yes	Yes	No	No	2	3
311	3x47	5x57	Shared	1.6	4.8	No	No	No	No	9	6
312	6x40	7x52	Shared	1.6	3.21	No	No	No	No	8	8
313	7x48	7x52	Shared	1.6	3.21	No	No	No	No	6	8
314	7x30	E3.C353	Shared	1.59	1.59	No	No	No	No	4	4
315	1x54	1x58	Shared	1.55	1.55	No	No	No	No	7	4
316	6x53	6x57	Shared	1.52	1.52	No	No	No	No	6	5
317	E2.D198	E2.V199	Shared	1.46	5.84	No	No	No	No	4	3
318	E1x49	E2.N204	Shared	1.4	15.43	No	No	Yes	No	3	3
319	2x38	4x39	Shared	1.38	1.38	No	No	No	Yes	6	4
320	I1x48	I1x51	Shared	1.36	4.07	Yes	No	No	No	7	8
321	E2.N201	E2.N203	Shared	1.36	2.72	Yes	Yes	No	No	2	4
322	2x41	4x42	Shared	1.33	1.33	Yes	No	No	No	5	7
323	5x45	5x48	Shared	1.22	3.65	No	No	No	No	4	6
324	6x42	6x46	Shared	1.22	3.65	No	No	No	No	6	5
325	7x55	8x51	Shared	1.21	2.43	No	No	No	No	6	9
326	1x40	7x39	5ht2b_on	0	8.22	No	No	Yes	Yes	7	7
327	1x43	2x58	5ht2b_on	0	3.39	No	No	No	No	6	9
328	1x54	2x44	5ht2b_on	0	2.92	No	No	No	No	7	7
329	1x55	8x58	5ht2b_on	0	4.28	No	No	No	Yes	4	6
330	1x59	8x58	5ht2b_on	0	5.71	No	No	No	Yes	4	6
331	1x60	8x53	5ht2b_on	0	6.03	Yes	No	No	No	7	7
332	2x50	7x46	5ht2b_on	0	8.83	Yes	Yes	No	No	9	9
333	2x50	7x49	5ht2b_on	0	8.08	Yes	Yes	No	No	9	9
334	2x52	2x551	5ht2b_on	0	3.65	No	No	No	No	7	5
335	2x53	7x46	5ht2b_on	0	6.46	No	No	No	No	7	9
336	2x56	3x28	5ht2b_on	0	6.13	No	No	Yes	No	7	6
337	E1.E118	E1x49	5ht2b_on	0	5.41	No	No	No	No	4	3
338	E1x51	E1x52	5ht2b_on	0	3.28	No	No	Yes	Yes	3	6
339	3x21	3x24	5ht2b_on	0	4.93	No	No	No	No	7	5
340	3x29	E2.I195	5ht2b_on	0	2.85	No	No	No	No	5	5
341	3x29	E2x52	5ht2b_on	0	5.54	No	No	No	No	5	5
342	3x37	4x53	5ht2b_on	0	6.4	No	No	No	No	7	8
343	3x38	3x42	5ht2b_on	0	2.93	No	No	Yes	Yes	8	8
344	3x40	6x44	5ht2b_on	0	3.77	No	No	Yes	No	8	9
345	3x43	7x53	5ht2b_on	0	8.21	No	No	No	Yes	9	9
346	3x46	3x50	5ht2b_on	0	6.26	No	No	No	No	9	9
347	3x46	7x53	5ht2b_on	0	3.63	No	No	No	Yes	9	9
348	3x50	7x53	5ht2b_on	0	6.17	No	No	No	Yes	9	9
349	I2x51	I2x52	5ht2b_on	0	6.86	No	No	No	No	7	5
350	I2x51	I2x55	5ht2b_on	0	4.12	No	No	No	No	7	0
351	I2x52	I2x56	5ht2b_on	0	3.38	No	No	No	No	5	0
352	4x46	4x50	5ht2b_on	0	3.52	No	No	Yes	Yes	7	9
353	4x52	4x56	5ht2b_on	0	2.94	No	No	No	No	5	6
354	E2.P202	E2.T197	5ht2b_on	0	8.74	No	No	No	No	3	4
355	E2.N201	E2.V199	5ht2b_on	0	2.96	Yes	Yes	No	No	2	3
356	E2.D200	E2.N201	5ht2b_on	0	10.77	No	No	Yes	Yes	4	2
357	E2.R213	E2.T210	5ht2b_on	0	3.88	No	Yes	No	No	3	5
358	6x58	E2.K211	5ht2b_on	0	4.23	No	No	Yes	Yes	4	5
359	5x39	5x43	5ht2b_on	0	3.01	Yes	No	No	No	7	6
360	5x47	5x51	5ht2b_on	0	3.65	Yes	Yes	No	No	8	6
361	5x47	6x44	5ht2b_on	0	3.22	Yes	Yes	Yes	No	8	9
362	5x53	5x57	5ht2b_on	0	3.04	No	No	No	No	8	6
363	5x54	6x44	5ht2b_on	0	8.71	Yes	No	Yes	No	8	9
364	5x58	6x38	5ht2b_on	0	4.35	No	Yes	No	No	9	5
365	5x58	6x41	5ht2b_on	0	5.16	No	Yes	Yes	No	9	8
366	5x65	6x30	5ht2b_on	0	5.3	No	No	No	No	8	8
367	5x67	6x30	5ht2b_on	0	9.45	No	No	No	No	6	8
368	5x68	6x28	5ht2b_on	0	7.65	No	No	No	No	7	4
369	6x27	6x31	5ht2b_on	0	4.12	No	No	No	No	4	6
370	6x27	6x35	5ht2b_on	0	5.82	No	No	No	No	4	7
371	6x28	6x31	5ht2b_on	0	7.22	No	No	No	No	4	6
372	6x31	6x34	5ht2b_on	0	2.89	No	No	No	No	6	7
373	6x36	7x56	5ht2b_on	0	15.73	No	No	No	No	8	7
374	6x40	7x53	5ht2b_on	0	5.05	No	No	No	Yes	8	9
375	6x45	6x49	5ht2b_on	0	4.76	No	No	No	No	5	6
376	7x38	7x42	5ht2b_on	0	6.31	No	No	Yes	Yes	6	8
377	7x45	7x49	5ht2b_on	0	4.47	No	No	No	No	9	9
378	7x50	7x51	5ht2b_on	0	3.28	Yes	No	No	No	9	6
379	7x54	7x55	5ht2b_on	0	2.95	Yes	No	No	No	7	6
380	8x47	8x49	5ht2b_on	0	5.85	No	No	No	No	9	7
381	1x56	8x50	5ht2b_on	0	2.77	No	No	Yes	Yes	8	9
382	2x40	2x43	5ht2b_on	0	2.75	Yes	No	No	No	9	8
383	1x60	8x58	5ht2b_on	0	2.73	Yes	No	No	Yes	7	6
384	1x57	8x50	5ht2b_on	0	2.62	No	No	Yes	Yes	8	9
385	1x35	1x37	5ht2b_on	0	2.59	No	No	No	No	4	6
386	6x27	6x32	5ht2b_on	0	2.51	No	No	No	No	4	8
387	2x37	2x39	5ht2b_on	0	2.5	No	No	No	No	7	8
388	2x41	I1x51	5ht2b_on	0	2.25	Yes	No	No	No	5	8
389	6x55	Lig	5ht2b_on	0	2.15	No	No	Yes	Yes	6	0
390	1x48	1x51	5ht2b_on	0	1.82	No	No	No	No	4	4
391	3x53	I2x53	5ht2b_on	0	1.79	No	No	No	No	8	8
392	3x44	3x48	5ht2b_on	0	1.71	No	No	No	No	7	6
393	E2.I205	E2.P202	5ht2b_on	0	1.69	No	No	No	No	2	3
394	6x57	6x61	5ht2b_on	0	1.69	No	No	No	No	5	5
395	6x57	E3.C353	5ht2b_on	0	1.69	No	No	No	No	5	4
396	3x52	I2x53	5ht2b_on	0	1.62	No	No	No	No	5	8
397	3x54	5x64	5ht2b_on	0	1.62	No	No	No	No	9	6
398	1x37	2x65	5ht2b_on	0	1.61	No	No	No	No	6	5
399	E1.A119	E1x49	5ht2b_on	0	1.61	No	No	No	No	3	3
400	3x55	5x64	5ht2b_on	0	1.61	No	No	No	No	7	6
401	E2.T210	E2x51	5ht2b_on	0	1.59	No	No	No	No	5	3
402	5x65	6x33	5ht2b_on	0	1.58	No	No	No	No	8	8
403	4x44	4x47	5ht2b_on	0	1.52	No	No	No	No	4	3
404	8x49	I1x49	5ht2b_on	0	1.5	No	No	No	No	7	6
405	6x43	7x48	5ht2b_on	0	1.49	No	No	No	No	5	6
406	6x43	7x52	5ht2b_on	0	1.49	No	No	No	No	5	8
407	4x54	4x59	5ht2b_on	0	1.47	No	No	Yes	No	4	4
408	E2.I195	E2.I205	5ht2b_on	0	1.47	No	No	No	No	5	2
409	5x61	6x37	5ht2b_on	0	1.47	No	No	Yes	No	9	8
410	2x39	I2x57	5ht2b_on	0	1.46	No	No	No	No	8	7
411	4x41	I2x57	5ht2b_on	0	1.46	No	No	No	No	7	7
412	1x40	1x41	5ht2b_on	0	1.43	No	No	No	No	7	3
413	3x27	3x30	5ht2b_on	0	1.39	No	No	No	No	4	6
414	2x62	E1x52	5ht2b_on	0	1.38	No	No	Yes	Yes	5	6
415	7x30	7x33	5ht2b_on	0	1.38	No	No	No	No	4	5
416	6x58	7x31	5ht2b_on	0	1.33	No	No	No	No	4	2
417	4x38	4x39	5ht2b_on	0	1.32	No	No	No	Yes	8	4
418	8x56	8x57	5ht2b_on	0	1.03	No	No	Yes	No	6	5

Orange: nodes, hubs and links specific of 5ht2b_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of 5ht2b_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	5ht2b_off Avg Int. Strength	5ht2b_on Avg Int. Strength	5ht2b_off Num Of Links	5ht2b_on Num Of Links	ConSurf
1	1x60	5ht2b_off	7.9775	4.38	4	2	7
2	I1x48	5ht2b_off	5.205	4.07	4	1	7
3	I1x50	5ht2b_off	7.5125	10.255	4	2	8
4	2x40	5ht2b_off	5.98	7.97	5	3	9
5	2x41	5ht2b_off	5.556	5.65333	5	3	5
6	2x42	5ht2b_off	4.31333	4.05	6	3	8
7	2x51	5ht2b_off	4.91	4.22333	4	3	7
8	3x25	5ht2b_off	5.152	5.42333	5	3	9
9	3x28	5ht2b_off	7.7625	5.95667	4	3	6
10	3x34	5ht2b_off	4.002	3.16667	5	3	6
11	3x51	5ht2b_off	6.345	4.86	4	3	8
12	4x59	5ht2b_off	4.5325	3.275	4	2	4
13	E2.N204	5ht2b_off	2.81	7.06	4	3	3
14	5x36	5ht2b_off	7.7075	8.23	4	2	5
15	5x39	5ht2b_off	4.93	3.26667	5	3	7
16	5x50	5ht2b_off	5.4675	5.58333	4	3	9
17	5x54	5ht2b_off	5.4475	5.76667	4	3	8
18	6x37	5ht2b_off	5.9575	3.165	4	2	8
19	6x41	5ht2b_off	6.33	4.445	7	2	8
20	6x44	5ht2b_off	6.75667	5.23333	6	3	9
21	6x48	5ht2b_off	7.13	6.49	7	3	8
22	7x37	5ht2b_off	5.67	4.905	4	2	5
23	7x50	5ht2b_off	5.685	6.525	4	2	9
24	7x54	5ht2b_off	6.1425	5.59667	4	3	7
25	8x54	5ht2b_off	4.92	4.43	5	2	7
26	8x57	5ht2b_off	4.21	1.03	5	1	5
27	Lig	Shared	8.24455	9.13571	11	7	0
28	1x50	Shared	4.6725	5.9	4	4	9
29	2x50	Shared	5.8225	6.182	4	5	9
30	2x57	Shared	3.85571	4.128	7	5	8
31	E1x50	Shared	7.35286	5.45833	7	6	7
32	E1x52	Shared	6.31	3.5375	4	4	6
33	3x32	Shared	8.1275	8.93	4	4	8
34	3x35	Shared	6.704	5.2425	5	4	6
35	3x42	Shared	7.712	5.955	5	6	8
36	4x50	Shared	4.66857	4.082	7	5	9
37	E2.N201	Shared	2.77	4.52	4	4	2
38	E2.K211	Shared	5.4825	3.1025	4	4	5
39	5x47	Shared	10.5425	6.99	4	6	8
40	6x51	Shared	7.84	7.3475	6	4	7
41	6x52	Shared	11.908	8.89	5	4	7
42	7x39	Shared	7.42714	4.596	7	5	7
43	7x42	Shared	4.914	5.818	5	5	8
44	8x50	Shared	8.288	7.024	5	5	9
45	4x39	5ht2b_on	3.97	4.555	3	4	4
46	E2.R213	5ht2b_on	7.14667	5.875	3	4	3
47	5x58	5ht2b_on	8.87	7.4625	2	4	9
48	7x53	5ht2b_on	5.06	5.765	2	4	9
49	8x58	5ht2b_on	2.63333	4.25	3	4	6

Orange: nodes, hubs and links specific of 5ht2b_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of 5ht2b_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	5ht2b_off Recurrence	5ht2b_on Recurrence	5ht2b_off Hub1?	5ht2b_on Hub1?	5ht2b_off Hub2?	5ht2b_on Hub2?	ConSurf1	ConSurf2
1	3x33	Lig	5ht2b_off	36.6977	3.05124	No	No	Yes	Yes	7	0
2	3x37	Lig	5ht2b_off	16.9735	0	No	No	Yes	Yes	7	0
3	E2x52	Lig	5ht2b_off	13.2766	0	No	No	Yes	Yes	5	0
4	6x52	Lig	5ht2b_off	45.9987	0	Yes	Yes	Yes	Yes	7	0
5	2x66	E1x51	5ht2b_off	14.9123	0	No	No	No	No	3	3
6	E1x50	E1x51	5ht2b_off	38.6049	2.41531	Yes	Yes	No	No	7	3
7	2x60	3x28	5ht2b_off	75.7133	0	No	No	Yes	No	7	6
8	2x60	7x39	5ht2b_off	77.5251	1.52868	No	No	Yes	Yes	7	7
9	7x39	7x42	5ht2b_off	10.1225	9.13538	Yes	Yes	Yes	Yes	7	8
10	1x35	1x38	5ht2b_off	10.0051	0	No	No	No	No	4	5
11	1x38	1x411	5ht2b_off	13.3133	0	No	No	No	No	5	4
12	1x411	1x42	5ht2b_off	19.8856	0	No	No	No	No	4	7
13	1x42	2x57	5ht2b_off	26.3992	3.35698	No	No	Yes	Yes	7	8
14	2x57	7x42	5ht2b_off	21.2206	9.71628	Yes	Yes	Yes	Yes	8	8
15	2x61	7x39	5ht2b_off	10.1152	0	No	No	Yes	Yes	6	7
16	2x50	3x39	5ht2b_off	13.1446	1.56537	Yes	Yes	No	No	9	9
17	3x39	7x46	5ht2b_off	14.0248	0	No	No	No	No	9	9
18	6x48	7x46	5ht2b_off	14.0101	0	Yes	No	No	No	8	9
19	6x48	6x51	5ht2b_off	87.3762	0	Yes	No	Yes	Yes	8	7
20	7x49	7x50	5ht2b_off	18.4699	0	No	No	Yes	No	9	9
21	6x44	7x49	5ht2b_off	15.4918	0	Yes	No	No	No	9	9
22	6x44	6x48	5ht2b_off	100	0	Yes	No	Yes	No	9	8
23	6x48	6x52	5ht2b_off	30.3088	1.19237	Yes	No	Yes	Yes	8	7
24	1x50	2x51	5ht2b_off	23.1717	8.0225	Yes	Yes	Yes	No	9	7
25	7x51	8x54	5ht2b_off	16.8782	0	No	No	Yes	No	6	7
26	8x50	8x54	5ht2b_off	45.874	0	Yes	Yes	Yes	No	9	7
27	1x57	2x40	5ht2b_off	81.3467	0	No	No	Yes	No	8	9
28	1x57	2x44	5ht2b_off	83.2759	4.66553	No	No	No	No	8	7
29	2x41	2x44	5ht2b_off	85.1904	0	Yes	No	No	No	5	7
30	2x41	4x46	5ht2b_off	98.1295	0	Yes	No	No	No	5	7
31	2x45	4x46	5ht2b_off	56.4439	0.593127	No	No	No	No	9	7
32	2x45	4x50	5ht2b_off	48.8521	0.953895	No	No	Yes	Yes	9	9
33	3x35	4x50	5ht2b_off	39.5291	0	Yes	Yes	Yes	Yes	6	9
34	2x53	3x35	5ht2b_off	49.6002	6.37153	No	No	Yes	Yes	7	6
35	2x53	2x56	5ht2b_off	10.6286	0	No	No	No	No	7	7
36	1x52	8x54	5ht2b_off	26.2231	9.23933	No	No	Yes	No	7	7
37	1x52	8x57	5ht2b_off	14.5749	0	No	No	Yes	No	7	5
38	2x48	2x52	5ht2b_off	12.1837	0	No	No	No	No	6	7
39	2x52	3x35	5ht2b_off	16.218	4.85508	No	No	Yes	Yes	7	6
40	1x60	I1x50	5ht2b_off	14.5162	0	Yes	No	Yes	No	7	8
41	2x40	I1x50	5ht2b_off	17.7437	0	Yes	No	Yes	No	9	8
42	2x42	3x42	5ht2b_off	22.915	5.96184	Yes	No	Yes	Yes	8	8
43	3x42	4x50	5ht2b_off	20.9198	1.77327	Yes	Yes	Yes	Yes	8	9
44	3x43	6x44	5ht2b_off	60.0822	0	No	No	Yes	No	9	9
45	3x43	6x41	5ht2b_off	63.4637	0	No	No	Yes	No	9	8
46	3x46	6x41	5ht2b_off	48.7787	0	No	No	Yes	No	9	8
47	2x42	3x46	5ht2b_off	48.3459	0	Yes	No	No	No	8	9
48	2x59	3x28	5ht2b_off	13.8121	2.47034	No	No	Yes	No	5	6
49	2x59	E1x52	5ht2b_off	11.5455	0	No	No	Yes	Yes	5	6
50	E1x49	E1x51	5ht2b_off	22.1741	0	No	No	No	No	3	3
51	3x25	E1x50	5ht2b_off	14.8683	4.92234	Yes	No	Yes	Yes	9	7
52	3x24	E1x52	5ht2b_off	14.4282	0	No	No	Yes	Yes	5	6
53	4x60	5x39	5ht2b_off	10.3939	0	No	No	Yes	No	8	7
54	3x33	4x57	5ht2b_off	34.6512	1.52868	No	No	No	No	7	8
55	3x34	4x57	5ht2b_off	33.7417	0	Yes	No	No	No	6	8
56	6x44	6x45	5ht2b_off	32.7808	0	Yes	No	No	No	9	5
57	5x54	6x45	5ht2b_off	26.4138	0	Yes	No	No	No	8	5
58	3x44	5x54	5ht2b_off	21.9761	7.55778	No	No	Yes	No	7	8
59	3x44	5x50	5ht2b_off	17.1936	0	No	No	Yes	No	7	9
60	3x47	5x57	5ht2b_off	11.6335	1.55925	No	No	No	No	9	6
61	6x37	6x41	5ht2b_off	44.6123	0	Yes	No	Yes	No	8	8
62	3x50	3x54	5ht2b_off	35.8615	0	No	No	No	No	9	9
63	5x61	5x65	5ht2b_off	21.9101	0	No	No	No	No	9	8
64	5x36	E2x52	5ht2b_off	10.2839	8.9764	Yes	No	No	No	5	5
65	5x36	5x39	5ht2b_off	11.5015	0	Yes	No	Yes	No	5	7
66	5x36	E2.R213	5ht2b_off	10.4819	7.50275	Yes	No	No	Yes	5	3
67	E1x49	E2.N204	5ht2b_off	19.7682	4.56157	No	No	Yes	No	3	3
68	E2.N201	E2.N204	5ht2b_off	12.4257	0	Yes	Yes	Yes	No	2	3
69	6x51	6x55	5ht2b_off	28.475	0	Yes	Yes	No	No	7	6
70	5x40	6x55	5ht2b_off	24.4187	7.54555	No	No	No	No	6	6
71	5x40	E2.K211	5ht2b_off	13.9294	0	No	No	Yes	Yes	6	5
72	5x44	6x52	5ht2b_off	14.6776	3.11239	No	No	Yes	Yes	7	7
73	5x44	6x56	5ht2b_off	12.3744	1.55925	No	No	No	No	7	6
74	5x47	5x48	5ht2b_off	10.9	3.11239	Yes	Yes	No	No	8	6
75	5x51	6x45	5ht2b_off	15.3525	1.55314	No	No	No	No	6	5
76	5x51	5x55	5ht2b_off	12.8292	0	No	No	No	No	6	5
77	5x55	5x59	5ht2b_off	10.2912	1.55925	No	No	No	No	5	3
78	6x51	7x34	5ht2b_off	46.006	6.18197	Yes	Yes	No	No	7	5
79	6x54	7x34	5ht2b_off	27.5728	4.6533	No	No	No	No	5	5
80	6x54	7x37	5ht2b_off	11.2008	3.11239	No	No	Yes	No	5	5
81	6x54	7x30	5ht2b_off	13.9661	0	No	No	No	No	5	4
82	7x31	7x34	5ht2b_off	16.7168	0	No	No	No	No	2	5
83	7x31	7x35	5ht2b_off	13.9661	0	No	No	No	No	2	5
84	7x32	7x35	5ht2b_off	11.2008	0	No	No	No	No	2	5
85	6x40	6x41	5ht2b_off	10.0565	0	No	No	Yes	No	8	8
86	3x28	3x29	5ht2b_off	10.966	0	Yes	No	No	No	6	5
87	7x38	7x39	5ht2b_off	59.9795	0	No	No	Yes	Yes	6	7
88	7x42	Lig	5ht2b_off	36.1623	0	Yes	Yes	Yes	Yes	8	0
89	3x34	4x50	5ht2b_off	29.854	0	Yes	No	Yes	Yes	6	9
90	2x53	2x57	5ht2b_off	41.0915	0	No	No	Yes	Yes	7	8
91	2x46	7x50	5ht2b_off	12.9025	0	No	No	Yes	No	9	9
92	2x57	7x39	5ht2b_off	37.996	0.214015	Yes	Yes	Yes	Yes	8	7
93	2x42	4x46	5ht2b_off	44.2823	0	Yes	No	No	No	8	7
94	5x47	6x48	5ht2b_off	10.8927	1.9139	Yes	Yes	Yes	No	8	8
95	5x39	Lig	Shared	40.3433	38.9079	Yes	No	Yes	Yes	7	0
96	6x51	Lig	Shared	51.9108	58.7379	Yes	Yes	Yes	Yes	7	0
97	3x28	E1x50	Shared	68.9577	35.4837	Yes	No	Yes	Yes	6	7
98	1x50	2x50	Shared	16.5994	59.0253	Yes	Yes	Yes	Yes	9	9
99	1x50	7x50	Shared	20.2963	51.8589	Yes	Yes	Yes	No	9	9
100	2x40	8x50	Shared	57.6836	20.6188	Yes	No	Yes	Yes	9	9
101	2x46	3x42	Shared	24.7194	83.2273	No	No	Yes	Yes	9	8
102	E1x50	E1x52	Shared	12.4257	21.6033	Yes	Yes	Yes	Yes	7	6
103	3x29	4x61	Shared	12.169	31.7537	No	No	No	No	5	6
104	4x61	5x39	Shared	18.1398	36.6271	No	No	Yes	No	6	7
105	3x37	4x56	Shared	10.2252	99.0706	No	No	No	No	7	6
106	3x50	6x37	Shared	40.2626	36.6027	No	No	Yes	No	9	8
107	3x54	5x65	Shared	26.6192	17.91	No	No	No	No	9	8
108	3x51	5x61	Shared	19.5335	34.1996	Yes	No	No	No	8	9
109	5x47	6x52	Shared	14.8463	93.1209	Yes	Yes	Yes	Yes	8	7
110	5x47	6x49	Shared	11.3695	21.9457	Yes	Yes	No	No	8	6
111	2x46	2x50	Shared	12.015	82.8177	No	No	Yes	Yes	9	9
112	6x51	7x38	Shared	51.3167	32.2001	Yes	Yes	No	No	7	6
113	5x54	6x41	Shared	13.46	10.6824	Yes	No	Yes	No	8	8
114	7x38	7x42	5ht2b_on	0	34.2485	No	No	Yes	Yes	6	8
115	6x51	6x52	5ht2b_on	6.01482	93.1454	Yes	Yes	Yes	Yes	7	7
116	5x47	6x44	5ht2b_on	0	99.5903	Yes	Yes	Yes	No	8	9
117	3x40	6x44	5ht2b_on	0	100	No	No	Yes	No	8	9
118	3x40	5x50	5ht2b_on	2.49395	99.9266	No	No	Yes	No	8	9
119	3x41	5x50	5ht2b_on	9.90978	99.7432	No	No	Yes	No	6	9
120	3x41	4x52	5ht2b_on	7.45251	99.6331	No	No	No	No	6	5
121	4x52	4x56	5ht2b_on	0	99.3763	No	No	No	No	5	6
122	3x37	4x53	5ht2b_on	0	98.7159	No	No	No	No	7	8
123	3x38	4x53	5ht2b_on	0.572141	87.7339	No	No	No	No	8	8
124	3x38	3x42	5ht2b_on	0	83.5637	No	No	Yes	Yes	8	8
125	3x34	4x53	5ht2b_on	1.69442	12.26	Yes	No	No	No	6	8
126	3x34	3x35	5ht2b_on	5.5307	10.4256	Yes	No	Yes	Yes	6	6
127	7x50	7x51	5ht2b_on	0	50.7521	Yes	No	No	No	9	6
128	7x51	7x55	5ht2b_on	9.79242	49.6331	No	No	No	No	6	6
129	7x54	7x55	5ht2b_on	0	46.2028	Yes	No	No	No	7	6
130	7x54	8x50	5ht2b_on	9.19093	42.644	Yes	No	Yes	Yes	7	9
131	1x56	8x50	5ht2b_on	0	12.2233	No	No	Yes	Yes	8	9
132	1x56	8x54	5ht2b_on	2.4206	10.7374	No	No	Yes	No	8	7
133	2x37	2x40	5ht2b_on	2.46461	17.91	No	No	Yes	No	7	9
134	2x37	2x39	5ht2b_on	0	16.473	No	No	No	No	7	8
135	2x39	I2x57	5ht2b_on	0	15.0177	No	No	No	No	8	7
136	2x38	I2x57	5ht2b_on	4.81185	12.2172	No	No	No	No	6	7
137	2x38	4x39	5ht2b_on	7.25446	10.7374	No	No	No	Yes	6	4
138	2x50	7x49	5ht2b_on	0	50.7643	Yes	Yes	No	No	9	9
139	2x56	7x42	5ht2b_on	6.40358	19.671	No	No	Yes	Yes	7	8
140	2x56	3x28	5ht2b_on	0	39.8924	No	No	Yes	No	7	6
141	2x62	E1x52	5ht2b_on	0	12.0704	No	No	Yes	Yes	5	6
142	3x32	Lig	5ht2b_on	7.10042	26.4339	Yes	Yes	Yes	Yes	8	0
143	3x29	E2.I195	5ht2b_on	0	21.536	No	No	No	No	5	5
144	E2.I195	E2.I205	5ht2b_on	0	20.3375	No	No	No	No	5	2
145	E2.I205	E2.P202	5ht2b_on	0	17.6043	No	No	No	No	2	3
146	E2.N201	E2.P202	5ht2b_on	2.51595	14.7915	Yes	Yes	No	No	2	3
147	3x43	7x49	5ht2b_on	4.26905	46.215	No	No	No	No	9	9
148	3x43	7x53	5ht2b_on	0	45.0165	No	No	No	Yes	9	9
149	5x54	6x44	5ht2b_on	0	19.1452	Yes	No	Yes	No	8	9
150	3x50	7x53	5ht2b_on	0	37.5749	No	No	No	Yes	9	9
151	5x61	6x37	5ht2b_on	0	35.4714	No	No	Yes	No	9	8
152	3x51	3x55	5ht2b_on	9.88044	30.2923	Yes	No	No	No	8	7
153	3x55	5x64	5ht2b_on	0	20.7472	No	No	No	No	7	6
154	3x54	5x64	5ht2b_on	0	19.3347	No	No	No	No	9	6
155	3x29	E2x52	5ht2b_on	0	10.2727	No	No	No	No	5	5
156	6x49	6x53	5ht2b_on	7.59187	19.243	No	No	No	No	6	6
157	6x53	6x57	5ht2b_on	3.7996	17.8244	No	No	No	No	6	5
158	6x57	E3.C353	5ht2b_on	0	13.3851	No	No	No	No	5	4
159	7x30	E3.C353	5ht2b_on	8.42074	12.0276	No	No	No	No	4	4
160	5x65	6x30	5ht2b_on	0	15.1584	No	No	No	No	8	8
161	5x68	6x30	5ht2b_on	2.48661	12.2111	No	No	No	No	7	8
162	5x68	6x28	5ht2b_on	0	10.7313	No	No	No	No	7	4
163	2x56	3x32	5ht2b_on	6.45493	22.496	No	No	Yes	Yes	7	8

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
3x32	Lig	Shared	15.35	18.04	1	1	1	0
3x33	Lig	Shared	12.36	15.14	0	0	1	0
3x36	Lig	Shared	7.93	5.87	1	1	1	0
3x37	Lig	5ht2b_off	5.56	0	0	0	1	0
E2x51	Lig	5ht2b_off	3.37	0	0	0	1	0
E2x52	Lig	5ht2b_off	5.22	0	0	0	1	0
5x39	Lig	Shared	5.51	2.86	0	0	1	0
6x51	Lig	Shared	16.54	15.23	1	1	1	0
6x52	Lig	5ht2b_off	11.94	0	1	1	1	0
7x38	Lig	Shared	3.37	4.66	1	1	1	0
7x42	Lig	5ht2b_off	3.54	0	1	1	1	0
2x56	3x32	Shared	5.84	2.92	1	1	2	1
2x56	7x42	Shared	3.79	3.79	1	1	2	1
2x57	7x39	Shared	4.65	3.49	1	1	2	2
2x57	7x42	Shared	3.59	4.79	1	1	2	1
3x29	4x61	Shared	2.98	4.47	0	0	2	2
3x32	3x36	Shared	4.42	4.42	1	1	1	1
3x32	7x42	Shared	6.9	10.34	1	1	1	1
3x33	4x57	Shared	3.39	3.39	0	0	1	2
3x37	4x56	Shared	4.56	3.04	0	0	1	2
4x60	5x39	5ht2b_off	7.22	0	0	0	2	1
4x61	5x39	Shared	5.24	3.93	0	0	2	1
5x36	E2x52	Shared	6.09	12.18	7	0	2	1
5x36	5x39	5ht2b_off	4.29	0	7	0	2	1
5x40	6x55	Shared	8.41	7.01	0	0	2	1
5x44	6x52	Shared	5.28	3.96	0	0	2	1
5x44	6x55	5ht2b_off	4.47	0	0	0	2	1
5x47	6x48	Shared	4.01	3.01	1	1	2	2
5x47	6x52	Shared	24.65	18.22	1	1	2	1
6x48	6x51	5ht2b_off	6.01	0	1	1	2	1
6x48	6x52	Shared	8.02	8.02	1	1	2	1
6x51	6x52	Shared	9.65	5.36	1	1	1	1
6x51	6x55	5ht2b_off	6.04	0	1	1	1	1
6x51	7x34	Shared	4.87	4.87	1	1	1	2
6x51	7x38	Shared	3.93	3.93	1	1	1	1
7x38	7x39	5ht2b_off	3.68	0	1	1	1	2
7x39	7x42	Shared	6.75	3.86	1	1	2	1
5x38	5x39	5ht2b_off	2.39	0	0	0	2	1
3x37	5x461	Shared	1.82	3.36	0	0	1	2
4x56	5x43	5ht2b_off	1.76	0	0	0	2	2
3x29	E2x52	5ht2b_on	0	5.54	0	0	2	1
3x37	4x53	5ht2b_on	0	6.4	0	0	1	2
5x39	5x43	5ht2b_on	0	3.01	0	0	1	2
7x38	7x42	5ht2b_on	0	6.31	1	1	1	1
6x55	Lig	5ht2b_on	0	2.15	0	0	1	0
E2.T210	E2x51	5ht2b_on	0	1.59	0	0	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	5ht2b_off	6DRZ-5-HT_2B-Methysergide
	5ht2b_on	7SRR-5-HT_2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2

Network Difference
Value	5ht2b_off	5ht2b_on
I_min	2.98	2.85
Number of Linked Nodes	284	255
Number of Specific Nodes	38 (13.38%)	9 (3.53%)
Number of Shared Nodes	246 (86.62%)	246 (96.47%)
Number of Links	325	263
Number of Specific Links	155 (47.69%)	93 (35.36%)
Number of Shared Links	170 (52.31%)	170 (64.64%)
Number of Hubs	44	23
Number of Specific Hubs	26 (59.09%)	5 (21.74%)
Number of Shared Hubs	18 (40.91%)	18 (78.26%)
Average % Shared Neighbours (Jaccard)	42.25
Average % Shared Neighbours (Otsuka)	51.14
Average % Shared Neighbours (Overlap Coefficient)	60.30
Average % Shared Cliques (k3-6)	79.38
Graphlets Similarity	0.595124

Paths Difference
Value	5ht2b_off	5ht2b_on
Number Of Nodes in MetaPath	101	69
Specific Nodes in MetaPath	59 (58.42%)	27 (39.13%)
Shared Nodes in MetaPath	246 (86.62%)	246 (86.62%)
Number Of Links MetaPath	113	69
Specific Links in MetaPath	94 (83.19%)	50 (72.46%)
Shared Links in MetaPath	170 (52.31%)	170 (52.31%)
Number of Shortest Paths	51510	31485
Length Of Smallest Path	3	3
Average Path Length	11.6294	18.4435
Length of Longest Path	27	45
Minimum Path Strength	1.22	1.3
Average Path Strength	5.72805	5.54714
Maximum Path Strength	18.295	16.635
Minimum Path Correlation	0.7	0.7
Average Path Correlation	0.943545	0.930507
Maximum Path Correlation	0.99	0.99
Minimum % Of Corr. Nodes	5.26316	2.7027
Average % Of Corr. Nodes	62.9928	51.9323
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	47.8568	27.1343
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

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