psnGPCR

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Orange: nodes, hubs and links specific of 5ht2c_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of 5ht2c_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	5ht2c_off Int. Strength	5ht2c_on Int. Strength	5ht2c_off Hub1?	5ht2c_on Hub1?	5ht2c_off Hub2?	5ht2c_on Hub2?	ConSurf1	ConSurf2
1	2x62	NT.F46	5ht2c_off	4.87	0	No	No	No	No	4	4
2	2x66	NT.F48	5ht2c_off	7.22	0	No	No	No	No	5	2
3	1x33	NT.V52	5ht2c_off	18.39	0	No	No	No	No	4	3
4	2x65	NT.V52	5ht2c_off	4.47	0	No	No	No	No	5	3
5	2x67	NT.Q53	5ht2c_off	19.58	0	No	No	No	No	4	3
6	1x32	1x34	5ht2c_off	4.89	0	No	No	No	No	4	4
7	1x32	1x35	5ht2c_off	6.25	0	No	No	No	No	4	6
8	1x33	1x37	5ht2c_off	3.42	0	No	No	No	No	4	4
9	1x47	2x55	5ht2c_off	4.28	0	No	No	No	No	6	4
10	1x48	1x51	5ht2c_off	5.29	0	No	No	Yes	No	4	4
11	1x49	7x50	5ht2c_off	4.06	0	No	No	No	No	8	9
12	1x50	2x47	5ht2c_off	4.69	0	No	Yes	No	No	9	9
13	1x51	1x55	5ht2c_off	4.37	0	Yes	No	No	No	4	5
14	1x51	2x51	5ht2c_off	4.37	0	Yes	No	No	No	4	7
15	1x53	7x53	5ht2c_off	5.05	0	No	No	Yes	Yes	9	9
16	1x53	8x54	5ht2c_off	5.24	0	No	No	Yes	No	9	7
17	1x55	8x57	5ht2c_off	7.18	0	No	No	Yes	No	5	5
18	1x55	CT.Y387	5ht2c_off	3.59	0	No	No	No	No	5	3
19	1x57	8x50	5ht2c_off	3.79	0	No	No	Yes	Yes	8	8
20	1x60	I1x50	5ht2c_off	5.3	0	No	No	Yes	No	6	8
21	1x60	8x57	5ht2c_off	5.61	0	No	No	Yes	No	6	5
22	8x49	I1x50	5ht2c_off	8.56	0	Yes	No	Yes	No	6	8
23	2x41	I1x51	5ht2c_off	5.44	0	No	No	No	Yes	4	8
24	2x37	2x40	5ht2c_off	12.26	0	No	No	Yes	No	7	9
25	2x40	2x43	5ht2c_off	4.12	0	Yes	No	No	No	9	8
26	2x41	4x39	5ht2c_off	8.23	0	No	No	No	Yes	4	4
27	2x42	4x45	5ht2c_off	4.96	0	No	No	No	No	8	6
28	2x43	7x53	5ht2c_off	11.72	0	No	No	Yes	Yes	8	9
29	2x50	7x49	5ht2c_off	4.04	0	Yes	Yes	No	No	9	9
30	2x56	3x28	5ht2c_off	3.68	0	No	No	No	No	7	5
31	2x57	7x39	5ht2c_off	8.14	0	Yes	Yes	Yes	Yes	8	7
32	2x62	E1x51	5ht2c_off	3.28	0	No	No	No	No	4	3
33	2x62	E1x52	5ht2c_off	4.15	0	No	No	Yes	No	4	6
34	2x64	E1.Y118	5ht2c_off	9.67	0	No	No	No	No	6	4
35	2x66	E1x51	5ht2c_off	11.13	0	No	No	No	No	5	3
36	7x35	E1.Y118	5ht2c_off	15.12	0	Yes	No	No	No	5	4
37	E1x50	E1x51	5ht2c_off	5.4	0	Yes	No	No	No	7	3
38	E1x50	E1x52	5ht2c_off	6.83	0	Yes	No	Yes	No	7	6
39	3x25	E1x50	5ht2c_off	6.53	0	Yes	Yes	Yes	No	9	7
40	3x28	E1x50	5ht2c_off	6.56	0	No	No	Yes	No	5	7
41	E1x50	E2.F201	5ht2c_off	6.01	0	Yes	No	Yes	Yes	7	4
42	E1x50	E2x50	5ht2c_off	11.75	0	Yes	No	Yes	No	7	9
43	3x21	E1x52	5ht2c_off	4.93	0	No	No	Yes	No	7	6
44	3x24	E1x52	5ht2c_off	5.54	0	No	No	Yes	No	5	6
45	3x21	3x23	5ht2c_off	5.56	0	No	No	No	No	7	1
46	3x22	E2.E197	5ht2c_off	5.82	0	No	No	No	No	3	3
47	3x22	E2.F201	5ht2c_off	19.24	0	No	No	Yes	Yes	3	4
48	3x22	E2.N204	5ht2c_off	12.05	0	No	No	No	No	3	2
49	3x23	3x24	5ht2c_off	4.69	0	No	No	No	No	1	5
50	3x25	E2.V200	5ht2c_off	3.42	0	Yes	Yes	No	No	9	3
51	3x26	4x65	5ht2c_off	4.06	0	Yes	No	No	No	6	5
52	3x26	E2.V200	5ht2c_off	5.3	0	Yes	No	No	No	6	3
53	3x29	E2x52	5ht2c_off	4.28	0	No	No	No	No	5	5
54	3x33	4x57	5ht2c_off	3.23	0	No	No	No	No	6	8
55	3x37	5x461	5ht2c_off	5.03	0	No	No	No	No	7	7
56	3x37	Lig	5ht2c_off	4.27	0	No	No	Yes	Yes	7	0
57	3x40	6x44	5ht2c_off	7.54	0	No	No	Yes	No	8	9
58	3x40	Lig	5ht2c_off	4.96	0	No	No	Yes	Yes	8	0
59	3x43	6x41	5ht2c_off	6.09	0	No	No	Yes	No	9	8
60	3x43	6x44	5ht2c_off	7.31	0	No	No	Yes	No	9	9
61	3x44	5x50	5ht2c_off	3.77	0	No	No	Yes	No	7	9
62	3x47	5x57	5ht2c_off	4.8	0	No	No	No	No	8	6
63	3x47	6x41	5ht2c_off	3.96	0	No	No	Yes	No	8	8
64	3x50	5x61	5ht2c_off	3.88	0	Yes	No	No	No	9	9
65	3x50	5x65	5ht2c_off	3.64	0	Yes	No	No	Yes	9	8
66	3x50	6x30	5ht2c_off	9.3	0	Yes	No	No	No	9	7
67	3x50	6x33	5ht2c_off	4.15	0	Yes	No	No	No	9	8
68	3x50	6x34	5ht2c_off	5.27	0	Yes	No	No	No	9	7
69	I2x55	I2x56	5ht2c_off	18.17	0	No	No	No	No	5	4
70	4x39	I2x57	5ht2c_off	3.62	0	No	Yes	No	No	4	6
71	4x38	4x41	5ht2c_off	9.18	0	No	No	No	No	8	7
72	4x64	5x39	5ht2c_off	3.77	0	No	No	Yes	No	4	7
73	E2.E197	E2.E198	5ht2c_off	3.81	0	No	No	No	No	3	3
74	E2.F201	E2x50	5ht2c_off	4.19	0	Yes	Yes	Yes	No	4	9
75	E2.T206	E2x51	5ht2c_off	4.76	0	No	No	No	No	4	4
76	E2x51	Lig	5ht2c_off	3.45	0	No	No	Yes	Yes	4	0
77	5x40	E2x52	5ht2c_off	4.47	0	No	No	No	No	6	5
78	5x36	5x39	5ht2c_off	4.78	0	Yes	No	Yes	No	5	7
79	5x44	5x48	5ht2c_off	3.96	0	No	No	Yes	No	7	6
80	5x47	Lig	5ht2c_off	4.94	0	Yes	Yes	Yes	Yes	8	0
81	5x54	6x41	5ht2c_off	7.46	0	No	No	Yes	No	8	8
82	5x63	5x67	5ht2c_off	12.35	0	No	No	No	No	4	5
83	5x64	5x68	5ht2c_off	5.73	0	No	No	No	No	6	7
84	6x25	6x32	5ht2c_off	4.07	0	No	No	No	No	4	8
85	6x35	7x56	5ht2c_off	4.96	0	No	No	Yes	No	7	7
86	6x37	6x41	5ht2c_off	8.53	0	No	No	Yes	No	8	8
87	6x39	7x56	5ht2c_off	5.02	0	No	No	Yes	No	6	7
88	6x40	7x49	5ht2c_off	5.91	0	No	No	No	No	8	9
89	6x44	7x45	5ht2c_off	12.08	0	Yes	No	No	No	9	9
90	6x48	6x51	5ht2c_off	7.02	0	Yes	Yes	Yes	Yes	8	7
91	6x48	6x52	5ht2c_off	5.01	0	Yes	Yes	Yes	Yes	8	7
92	6x48	Lig	5ht2c_off	11.88	0	Yes	Yes	Yes	Yes	8	0
93	6x49	6x53	5ht2c_off	3.27	0	No	No	No	No	6	6
94	6x51	6x55	5ht2c_off	7.25	0	Yes	Yes	No	No	7	7
95	7x27	E3.K339	5ht2c_off	4.07	0	No	No	No	No	1	2
96	7x35	Lig	5ht2c_off	4.78	0	Yes	No	Yes	Yes	5	0
97	7x38	7x39	5ht2c_off	3.68	0	Yes	No	Yes	Yes	7	7
98	7x38	Lig	5ht2c_off	12.95	0	Yes	No	Yes	Yes	7	0
99	7x42	Lig	5ht2c_off	5.44	0	Yes	Yes	Yes	Yes	8	0
100	7x53	8x50	5ht2c_off	7.94	0	Yes	Yes	Yes	Yes	9	8
101	7x54	8x51	5ht2c_off	3.88	0	No	No	No	No	7	9
102	7x54	8x54	5ht2c_off	7.78	0	No	No	Yes	No	7	7
103	7x55	7x56	5ht2c_off	4.87	0	No	No	Yes	No	5	7
104	8x50	8x54	5ht2c_off	4.13	0	Yes	Yes	Yes	No	8	7
105	8x53	8x57	5ht2c_off	6.67	0	No	No	Yes	No	7	5
106	8x56	8x59	5ht2c_off	3.62	0	No	No	No	No	5	5
107	8x57	CT.N386	5ht2c_off	3.49	0	Yes	No	No	No	5	3
108	8x60	CT.N386	5ht2c_off	4.72	0	No	No	No	No	8	3
109	NT.D50	NT.P49	5ht2c_off	3.22	0	No	No	No	No	2	4
110	6x40	7x52	5ht2c_off	3.21	0	No	No	No	No	8	8
111	1x40	1x44	5ht2c_off	3.07	0	No	No	No	No	4	4
112	1x42	7x43	5ht2c_off	3.07	0	No	No	No	No	7	4
113	1x58	2x44	5ht2c_off	3.07	0	No	No	No	No	3	5
114	6x43	6x47	5ht2c_off	3.04	0	No	No	Yes	No	6	8
115	1x37	1x40	5ht2c_off	2.98	0	No	No	No	No	4	4
116	1x54	2x51	5ht2c_off	2.92	0	No	No	No	No	7	7
117	8x48	8x49	5ht2c_off	2.91	0	No	No	Yes	No	5	6
118	2x66	NT.G51	5ht2c_off	2.9	0	No	No	No	No	5	2
119	4x60	5x39	5ht2c_off	2.89	0	No	No	Yes	No	7	7
120	3x46	6x37	5ht2c_off	2.85	0	No	Yes	No	No	9	8
121	3x54	5x65	5ht2c_off	2.85	0	No	No	No	Yes	9	8
122	6x45	6x46	5ht2c_off	2.85	0	No	No	No	No	5	5
123	1x33	NT.P49	5ht2c_off	2.7	0	No	No	No	No	4	4
124	1x56	8x57	5ht2c_off	2.67	0	No	No	Yes	No	7	5
125	6x25	6x28	5ht2c_off	2.64	0	No	No	No	No	4	5
126	7x52	7x56	5ht2c_off	2.62	0	No	No	Yes	No	8	7
127	2x63	E1x50	5ht2c_off	2.59	0	No	No	Yes	No	4	7
128	6x31	6x35	5ht2c_off	2.48	0	No	No	No	No	5	7
129	5x58	6x42	5ht2c_off	2.06	0	Yes	Yes	No	No	9	6
130	4x55	4x59	5ht2c_off	1.84	0	No	No	No	No	4	4
131	2x38	4x42	5ht2c_off	1.79	0	No	No	No	No	5	8
132	6x61	E3.S340	5ht2c_off	1.72	0	No	No	No	No	3	2
133	E3.C341	E3.S340	5ht2c_off	1.72	0	No	No	No	No	3	2
134	2x38	4x38	5ht2c_off	1.71	0	No	No	No	No	5	8
135	4x56	5x461	5ht2c_off	1.7	0	No	No	No	No	6	7
136	NT.K47	NT.P49	5ht2c_off	1.67	0	No	No	No	No	4	4
137	1x35	2x64	5ht2c_off	1.62	0	No	No	No	No	6	6
138	3x53	3x54	5ht2c_off	1.62	0	No	No	No	No	8	9
139	E1x49	E2.T205	5ht2c_off	1.59	0	No	Yes	No	No	3	3
140	E2.T205	E2.T206	5ht2c_off	1.57	0	No	No	No	No	3	4
141	4x48	4x49	5ht2c_off	1.54	0	No	No	No	No	2	7
142	5x42	5x46	5ht2c_off	1.54	0	No	No	No	No	4	5
143	7x36	7x40	5ht2c_off	1.54	0	No	No	No	No	5	8
144	2x39	3x46	5ht2c_off	1.52	0	No	No	No	Yes	8	9
145	5x54	5x55	5ht2c_off	1.52	0	No	No	No	No	8	5
146	3x48	3x52	5ht2c_off	1.49	0	No	No	No	No	6	5
147	4x38	I2x57	5ht2c_off	1.49	0	No	No	No	No	8	6
148	4x40	I2x57	5ht2c_off	1.46	0	No	No	No	No	5	6
149	8x49	I1x49	5ht2c_off	1.45	0	Yes	No	No	No	6	5
150	I2x52	I2x54	5ht2c_off	1.44	0	No	No	No	No	5	5
151	3x56	I2x51	5ht2c_off	1.42	0	No	No	No	No	5	7
152	6x27	6x28	5ht2c_off	1.42	0	No	No	No	No	4	5
153	7x32	7x35	5ht2c_off	1.4	0	No	No	Yes	No	3	5
154	6x57	6x60	5ht2c_off	1.38	0	No	No	No	No	5	5
155	1x32	2x67	5ht2c_off	1.35	0	No	No	No	No	4	4
156	5x58	5x59	5ht2c_off	1.34	0	Yes	Yes	No	No	9	2
157	4x41	I2x53	5ht2c_off	1.31	0	No	No	No	Yes	7	8
158	4x40	I2x56	5ht2c_off	1.3	0	No	No	No	No	5	4
159	1x39	2x61	Shared	5.71	2.85	No	No	No	No	7	6
160	1x39	7x39	Shared	4.7	4.7	No	No	Yes	Yes	7	7
161	1x41	1x45	Shared	4.37	2.92	No	No	No	No	4	4
162	1x43	2x57	Shared	4.37	8.02	No	Yes	Yes	Yes	7	8
163	1x46	2x57	Shared	9.03	3.765	No	No	Yes	Yes	7	8
164	1x46	7x47	Shared	5.46	5.46	No	No	No	No	7	7
165	1x50	2x50	Shared	6.73	6.73	No	Yes	Yes	Yes	9	9
166	1x50	7x50	Shared	9.77	5.705	No	Yes	No	No	9	9
167	1x52	8x54	Shared	7.31	6.7	No	Yes	Yes	No	7	7
168	1x52	8x57	Shared	3.52	2.34	No	Yes	Yes	No	7	5
169	1x53	2x47	Shared	3.39	3.39	No	No	No	No	9	9
170	1x57	2x44	Shared	9.13	9.13	No	No	No	No	8	5
171	1x59	8x57	Shared	5.99	8.38	No	No	Yes	No	5	5
172	1x60	8x53	Shared	4.53	3.77	No	No	No	No	6	7
173	2x40	I1x50	Shared	4.12	10.295	Yes	No	Yes	No	9	8
174	8x50	I1x50	Shared	10.55	2.93	Yes	Yes	Yes	No	8	8
175	2x40	8x50	Shared	5.81	6.98	Yes	No	Yes	Yes	9	8
176	2x42	3x45	Shared	4.16	4.16	No	No	No	No	8	7
177	2x42	3x46	Shared	7.54	5.65	No	No	No	Yes	8	9
178	2x45	3x42	Shared	8.37	6.97	No	No	Yes	Yes	9	8
179	2x45	4x46	Shared	4.64	5.415	No	No	No	No	9	8
180	2x45	4x50	Shared	6.18	6.18	No	No	Yes	Yes	9	9
181	2x46	2x50	Shared	8.14	5.43	No	No	Yes	Yes	9	9
182	2x46	3x42	Shared	7.71	8.355	No	No	Yes	Yes	9	8
183	2x50	3x39	Shared	4.42	3.68	Yes	Yes	No	No	9	9
184	2x50	7x46	Shared	8.83	10.31	Yes	Yes	No	No	9	9
185	2x52	3x35	Shared	14.61	10.96	No	No	Yes	Yes	6	7
186	2x53	7x46	Shared	8.08	3.23	No	Yes	No	No	7	9
187	2x54	2x57	Shared	5.24	5.24	No	No	Yes	Yes	6	8
188	2x551	3x35	Shared	3.65	2.44	No	No	Yes	Yes	4	7
189	2x56	3x32	Shared	7.3	13.15	No	No	No	No	7	8
190	2x56	7x42	Shared	5.05	5.68	No	No	Yes	Yes	7	8
191	2x59	3x28	Shared	10.25	9.68	No	No	No	No	5	5
192	2x60	7x39	Shared	9.88	4.94	No	No	Yes	Yes	7	7
193	2x64	7x39	Shared	5.87	4.695	No	No	Yes	Yes	6	7
194	3x25	3x26	Shared	5.65	1.88	Yes	Yes	Yes	No	9	6
195	3x25	3x29	Shared	3.27	3.27	Yes	Yes	No	No	9	5
196	3x25	E2.F201	Shared	8.38	4.19	Yes	Yes	Yes	Yes	9	4
197	3x25	E2x50	Shared	7.28	7.28	Yes	Yes	Yes	No	9	9
198	3x26	4x66	Shared	6.57	1.64	Yes	No	No	No	6	6
199	3x29	E2x50	Shared	3.27	3.27	No	No	Yes	No	5	9
200	3x30	4x62	Shared	7.13	3.56	No	No	No	No	6	7
201	3x31	3x35	Shared	3.65	2.435	No	No	Yes	Yes	5	7
202	3x32	7x42	Shared	8.05	10.34	No	No	Yes	Yes	8	8
203	3x32	Lig	Shared	14.95	13.165	No	No	Yes	Yes	8	0
204	3x33	4x61	Shared	4.61	3.84	No	No	No	Yes	6	6
205	3x33	Lig	Shared	6.91	19.225	No	No	Yes	Yes	6	0
206	3x34	3x35	Shared	7.31	6.09	No	No	Yes	Yes	6	7
207	3x34	4x57	Shared	7.51	6.76	No	No	No	No	6	8
208	3x35	4x50	Shared	4.01	4.01	Yes	Yes	Yes	Yes	7	9
209	3x36	Lig	Shared	12.19	9.87	No	No	Yes	Yes	6	0
210	3x38	4x50	Shared	5.19	3.89	No	No	Yes	Yes	8	9
211	3x38	4x53	Shared	3.42	3.42	No	No	No	No	8	8
212	3x40	5x50	Shared	3.39	3.39	No	No	Yes	No	8	9
213	3x41	5x50	Shared	5.03	2.515	No	No	Yes	No	6	9
214	3x42	4x49	Shared	6.92	8.305	Yes	Yes	No	No	8	7
215	3x42	4x50	Shared	7.41	4.23	Yes	Yes	Yes	Yes	8	9
216	3x44	5x53	Shared	4.91	3.27	No	No	No	No	7	6
217	3x49	4x45	Shared	9.68	8.3	No	No	No	No	9	6
218	3x50	6x37	Shared	4.86	3.035	Yes	No	No	No	9	8
219	3x51	5x57	Shared	6.24	2.5	Yes	Yes	No	No	8	6
220	3x51	5x60	Shared	8.21	8.205	Yes	Yes	No	No	8	6
221	3x51	5x61	Shared	6.24	6.24	Yes	Yes	No	No	8	9
222	3x54	5x64	Shared	4.61	1.54	No	No	No	No	9	6
223	I2x51	I2x52	Shared	4.1	1.365	No	No	No	No	7	5
224	4x41	4x45	Shared	7.18	22.27	No	No	No	No	7	6
225	4x59	4x60	Shared	5.3	3.53	No	No	No	No	4	7
226	4x61	4x62	Shared	3.39	3.39	No	Yes	No	No	6	7
227	4x61	5x39	Shared	6.28	4.395	No	Yes	Yes	No	6	7
228	4x64	E2.K199	Shared	4.36	6.545	No	No	No	Yes	4	3
229	4x65	E2.V200	Shared	5.52	2.76	No	No	No	No	5	3
230	4x68	E2.E198	Shared	6.5	2.6	No	No	No	No	4	3
231	4x68	E2.K199	Shared	6.91	11.06	No	No	No	Yes	4	3
232	5x36	E2.K199	Shared	16.59	6.91	Yes	No	No	Yes	5	3
233	E2.N203	E2.V202	Shared	5.91	1.48	No	No	No	No	4	1
234	E2.N210	E2.V202	Shared	7.39	6.65	No	No	No	No	4	1
235	5x36	5x37	Shared	4.83	8.05	Yes	No	No	No	5	5
236	5x44	6x52	Shared	3.96	3.96	No	No	Yes	Yes	7	7
237	5x44	Lig	Shared	5.22	7.865	No	No	Yes	Yes	7	0
238	5x45	5x48	Shared	5.36	11.79	No	No	Yes	No	4	6
239	5x47	5x48	Shared	4.29	9.65	Yes	Yes	Yes	No	8	6
240	5x47	5x51	Shared	3.65	2.44	Yes	Yes	No	No	8	6
241	5x47	6x52	Shared	34.29	24.115	Yes	Yes	Yes	Yes	8	7
242	5x48	6x56	Shared	5.02	2.51	Yes	No	No	No	6	6
243	5x49	5x50	Shared	3.39	3.39	No	No	Yes	No	5	9
244	5x51	6x45	Shared	8.3	2.075	No	No	No	No	6	5
245	5x58	5x62	Shared	4.84	12.09	Yes	Yes	No	No	9	5
246	5x58	6x38	Shared	7.24	5.07	Yes	Yes	No	No	9	5
247	5x58	6x41	Shared	8.25	5.67	Yes	Yes	Yes	No	9	8
248	5x62	6x34	Shared	4.64	3.1	No	No	No	No	5	7
249	5x69	6x27	Shared	4.87	0.81	No	No	No	No	6	4
250	6x25	6x29	Shared	10.56	0.66	No	No	No	No	4	6
251	6x36	7x56	Shared	3.93	5.24	No	No	Yes	No	8	7
252	6x44	6x48	Shared	10.02	7.515	Yes	No	Yes	Yes	9	8
253	6x47	7x45	Shared	8.41	8.105	Yes	No	No	No	8	9
254	6x48	7x41	Shared	12.67	6.335	Yes	Yes	No	No	8	7
255	6x50	7x37	Shared	10.11	6.5	No	No	No	Yes	9	6
256	6x51	6x52	Shared	8.57	3.755	Yes	Yes	Yes	Yes	7	7
257	6x51	7x34	Shared	4.87	3.045	Yes	Yes	No	No	7	4
258	6x51	7x38	Shared	5.24	7.87	Yes	Yes	Yes	No	7	7
259	6x51	Lig	Shared	8.47	6.055	Yes	Yes	Yes	Yes	7	0
260	6x52	Lig	Shared	9.88	2.86	Yes	Yes	Yes	Yes	7	0
261	6x54	7x34	Shared	7.37	4.42	No	No	No	No	5	4
262	6x54	7x37	Shared	7.78	5.84	No	No	No	Yes	5	6
263	6x55	7x34	Shared	5.49	2.75	No	No	No	No	7	4
264	6x58	7x27	Shared	4.33	5.78	No	No	No	No	4	1
265	6x58	7x30	Shared	6.13	4.6	No	No	No	No	4	4
266	6x61	E3.C341	Shared	7.28	4.55	No	No	No	No	3	3
267	7x26	7x29	Shared	5.49	1.375	No	No	No	No	4	4
268	7x29	7x33	Shared	5.54	0.69	No	No	No	No	4	5
269	7x31	7x35	Shared	6.57	5.26	No	No	Yes	No	3	5
270	7x33	7x37	Shared	8.53	2.44	No	No	No	Yes	5	6
271	7x38	7x42	Shared	6.31	5.05	Yes	No	Yes	Yes	7	8
272	7x39	7x42	Shared	7.72	4.825	Yes	Yes	Yes	Yes	7	8
273	7x49	7x53	Shared	5.81	2.905	No	No	Yes	Yes	9	9
274	8x47	8x49	Shared	9.91	9.205	No	No	Yes	No	8	6
275	8x47	8x50	Shared	4.65	1.16	No	No	Yes	Yes	8	8
276	8x48	8x52	Shared	16.09	6.19	No	No	No	No	5	4
277	8x55	8x56	Shared	4.47	0.745	No	No	No	No	5	5
278	E2.V202	E2x51	Shared	3.21	3.21	No	No	No	No	1	4
279	6x45	6x49	Shared	3.17	3.17	No	No	No	No	5	6
280	7x43	7x48	Shared	3.07	1.54	No	No	No	No	4	6
281	6x47	7x43	Shared	3.04	3.04	Yes	No	No	No	8	4
282	6x54	7x30	Shared	3.01	0.755	No	No	No	No	5	4
283	1x47	1x51	Shared	2.94	2.94	No	No	Yes	No	6	4
284	1x54	2x48	Shared	2.94	5.155	No	No	No	No	7	6
285	1x54	2x44	Shared	2.92	2.915	No	No	No	No	7	5
286	3x41	4x52	Shared	2.92	1.46	No	No	No	No	6	4
287	6x47	7x40	Shared	2.92	4.37	Yes	No	No	No	8	8
288	3x48	5x53	Shared	2.85	4.28	No	No	No	No	6	6
289	5x56	5x60	Shared	2.85	2.85	No	No	No	No	4	6
290	1x52	8x58	Shared	2.77	0.69	No	Yes	No	No	7	7
291	2x61	2x65	Shared	2.77	2.77	No	No	No	No	6	5
292	1x56	8x50	Shared	2.67	2.67	No	No	Yes	Yes	7	8
293	2x49	4x50	Shared	2.59	2.59	No	No	Yes	Yes	8	9
294	5x63	5x64	Shared	2.52	1.26	No	No	No	No	4	6
295	3x55	3x56	Shared	2.41	11.45	No	No	No	No	6	5
296	3x51	3x55	Shared	2.06	14.405	Yes	Yes	No	No	8	6
297	5x43	Lig	Shared	1.98	1.74	No	No	Yes	Yes	7	0
298	5x42	5x43	Shared	1.76	2.645	No	No	No	No	4	7
299	1x43	2x58	Shared	1.69	2.54	No	Yes	No	No	7	9
300	5x52	5x56	Shared	1.52	3.04	No	No	No	No	4	4
301	5x41	6x59	Shared	1.49	5.96	No	No	No	No	5	6
302	7x28	7x32	Shared	1.44	15.8	No	No	No	No	1	3
303	3x34	4x54	Shared	1.43	2.85	No	No	No	No	6	4
304	7x26	7x28	Shared	1.4	5.6	No	No	No	No	4	1
305	7x51	7x55	Shared	1.38	1.38	No	No	No	No	6	5
306	5x36	5x38	Shared	1.35	4.04	Yes	No	No	No	5	4
307	1x42	7x39	5ht2c_on	0	2.935	No	No	Yes	Yes	7	7
308	1x43	1x47	5ht2c_on	0	2.94	No	Yes	No	No	7	6
309	1x46	1x50	5ht2c_on	0	2.925	No	No	No	Yes	7	9
310	1x50	2x51	5ht2c_on	0	4.21	No	Yes	No	No	9	7
311	1x54	2x47	5ht2c_on	0	3.25	No	No	No	No	7	9
312	1x55	1x58	5ht2c_on	0	3.07	No	No	No	No	5	3
313	1x55	1x59	5ht2c_on	0	2.89	No	No	No	No	5	5
314	1x56	8x54	5ht2c_on	0	2.77	No	No	Yes	No	7	7
315	1x57	I1x50	5ht2c_on	0	3.725	No	No	Yes	No	8	8
316	1x59	1x60	5ht2c_on	0	3.385	No	No	No	No	5	6
317	2x37	I1x51	5ht2c_on	0	3.19	No	No	No	Yes	7	8
318	2x38	I1x51	5ht2c_on	0	5.12	No	No	No	Yes	5	8
319	I1x51	I2x57	5ht2c_on	0	5.1	No	Yes	No	No	8	6
320	2x37	2x41	5ht2c_on	0	18.605	No	No	No	No	7	4
321	2x39	2x40	5ht2c_on	0	3.655	No	No	Yes	No	8	9
322	2x42	3x42	5ht2c_on	0	13.575	No	No	Yes	Yes	8	8
323	2x46	3x39	5ht2c_on	0	3	No	No	No	No	9	9
324	2x48	2x52	5ht2c_on	0	2.85	No	No	No	No	6	6
325	2x50	7x50	5ht2c_on	0	8.05	Yes	Yes	No	No	9	9
326	2x51	2x55	5ht2c_on	0	3.535	No	No	No	No	7	4
327	2x53	2x54	5ht2c_on	0	2.76	No	Yes	No	No	7	6
328	2x53	2x56	5ht2c_on	0	3.21	No	Yes	No	No	7	7
329	2x53	3x35	5ht2c_on	0	3.275	No	Yes	Yes	Yes	7	7
330	2x57	7x42	5ht2c_on	0	2.99	Yes	Yes	Yes	Yes	8	8
331	2x60	3x28	5ht2c_on	0	3.71	No	No	No	No	7	5
332	2x62	2x66	5ht2c_on	0	8.205	No	No	No	No	4	5
333	E1x49	E2.F201	5ht2c_on	0	6.55	No	Yes	Yes	Yes	3	4
334	E1x49	E2.T206	5ht2c_on	0	3.965	No	Yes	No	No	3	4
335	3x29	4x61	5ht2c_on	0	4.42	No	No	No	Yes	5	6
336	3x30	4x57	5ht2c_on	0	4.89	No	No	No	No	6	8
337	3x30	4x61	5ht2c_on	0	10.065	No	No	No	Yes	6	6
338	3x33	4x56	5ht2c_on	0	3.21	No	No	No	No	6	6
339	3x37	4x56	5ht2c_on	0	4.76	No	No	No	No	7	6
340	3x40	6x48	5ht2c_on	0	2.935	No	No	Yes	Yes	8	8
341	3x43	7x49	5ht2c_on	0	8.925	No	No	No	No	9	9
342	3x43	7x53	5ht2c_on	0	6.445	No	No	Yes	Yes	9	9
343	3x46	3x50	5ht2c_on	0	5.01	No	Yes	Yes	No	9	9
344	3x46	7x53	5ht2c_on	0	6.04	No	Yes	Yes	Yes	9	9
345	3x47	5x54	5ht2c_on	0	5.365	No	No	No	No	8	8
346	3x49	I2x53	5ht2c_on	0	5.67	No	No	No	Yes	9	8
347	3x49	4x41	5ht2c_on	0	5.53	No	No	No	No	9	7
348	3x50	7x53	5ht2c_on	0	6.685	Yes	No	Yes	Yes	9	9
349	3x53	I2x53	5ht2c_on	0	8.05	No	No	No	Yes	8	8
350	3x56	I2x52	5ht2c_on	0	8.545	No	No	No	No	5	5
351	I2x51	I2x55	5ht2c_on	0	4.385	No	No	No	No	7	5
352	I2x53	I2x57	5ht2c_on	0	14.665	No	Yes	No	No	8	6
353	4x41	I2x56	5ht2c_on	0	11.79	No	No	No	No	7	4
354	4x38	4x39	5ht2c_on	0	9.88	No	No	No	Yes	8	4
355	4x38	4x40	5ht2c_on	0	4.8	No	No	No	No	8	5
356	4x39	4x40	5ht2c_on	0	4.525	No	Yes	No	No	4	5
357	4x44	4x48	5ht2c_on	0	3.645	No	No	No	No	3	2
358	4x48	4x52	5ht2c_on	0	2.94	No	No	No	No	2	4
359	4x49	4x50	5ht2c_on	0	3.065	No	No	Yes	Yes	7	9
360	4x50	4x53	5ht2c_on	0	4.325	Yes	Yes	No	No	9	8
361	E2.E197	E2.F201	5ht2c_on	0	6.415	No	No	Yes	Yes	3	4
362	E2.K199	E2.V200	5ht2c_on	0	3.795	No	Yes	No	No	3	3
363	E2.F201	E2.V200	5ht2c_on	0	3.93	Yes	Yes	No	No	4	3
364	E2.F201	E2.T206	5ht2c_on	0	3.89	Yes	Yes	No	No	4	4
365	5x39	E2x52	5ht2c_on	0	7.31	Yes	No	No	No	7	5
366	5x37	6x59	5ht2c_on	0	3.53	No	No	No	No	5	6
367	5x39	Lig	5ht2c_on	0	5.045	Yes	No	Yes	Yes	7	0
368	5x40	6x55	5ht2c_on	0	5.91	No	No	No	No	6	7
369	5x41	6x60	5ht2c_on	0	6.92	No	No	No	No	5	5
370	5x461	Lig	5ht2c_on	0	3.325	No	No	Yes	Yes	7	0
371	5x47	6x48	5ht2c_on	0	4.01	Yes	Yes	Yes	Yes	8	8
372	5x54	6x44	5ht2c_on	0	11.82	No	No	Yes	No	8	9
373	5x55	6x41	5ht2c_on	0	5.895	No	No	Yes	No	5	8
374	5x61	6x37	5ht2c_on	0	2.95	No	No	No	No	9	8
375	5x62	5x66	5ht2c_on	0	3.76	No	No	No	No	5	6
376	5x65	5x66	5ht2c_on	0	3.64	No	Yes	No	No	8	6
377	5x65	6x34	5ht2c_on	0	3.75	No	Yes	No	No	8	7
378	5x66	6x34	5ht2c_on	0	7.91	No	No	No	No	6	7
379	5x67	5x70	5ht2c_on	0	6.68	No	No	No	No	5	0
380	5x67	5x71	5ht2c_on	0	3.72	No	No	No	No	5	0
381	5x68	6x30	5ht2c_on	0	6.37	No	No	No	No	7	7
382	6x24	6x26	5ht2c_on	0	4.83	No	No	No	No	0	4
383	6x24	6x27	5ht2c_on	0	3.645	No	No	No	No	0	4
384	6x27	6x31	5ht2c_on	0	3.76	No	No	No	No	4	5
385	6x40	7x53	5ht2c_on	0	5.05	No	No	Yes	Yes	8	9
386	6x48	7x45	5ht2c_on	0	8.49	Yes	Yes	No	No	8	9
387	E3.C341	E3.E338	5ht2c_on	0	5.32	No	No	No	No	3	1
388	7x27	E3.E338	5ht2c_on	0	13.38	No	No	No	No	1	1
389	7x27	7x30	5ht2c_on	0	4.08	No	No	No	No	1	4
390	7x28	7x31	5ht2c_on	0	7.425	No	No	No	No	1	3
391	7x31	7x32	5ht2c_on	0	11.475	No	No	No	No	3	3
392	7x47	7x50	5ht2c_on	0	3.045	No	No	No	No	7	9
393	7x54	8x50	5ht2c_on	0	7.49	No	No	Yes	Yes	7	8
394	8x47	8x48	5ht2c_on	0	4.195	No	No	No	No	8	5
395	8x48	8x51	5ht2c_on	0	3.095	No	No	No	No	5	9
396	2x39	I1x51	5ht2c_on	0	2.74	No	No	No	Yes	8	8
397	1x49	1x52	5ht2c_on	0	2.565	No	No	No	Yes	8	7
398	7x52	7x53	5ht2c_on	0	2.52	No	No	Yes	Yes	8	9
399	6x57	6x61	5ht2c_on	0	2.38	No	No	No	No	5	3
400	5x58	6x37	5ht2c_on	0	2.34	Yes	Yes	No	No	9	8
401	I2x51	I2x54	5ht2c_on	0	2.325	No	No	No	No	7	5
402	5x69	6x30	5ht2c_on	0	2.265	No	No	No	No	6	7
403	3x27	3x31	5ht2c_on	0	2.235	No	No	No	No	4	5
404	3x48	5x57	5ht2c_on	0	2.21	No	No	No	No	6	6
405	6x35	6x39	5ht2c_on	0	2.18	No	No	No	No	7	6
406	6x53	6x57	5ht2c_on	0	2.14	No	No	No	No	6	5
407	1x48	1x49	5ht2c_on	0	2.11	No	No	No	No	4	8
408	5x68	5x71	5ht2c_on	0	2.04	No	No	No	No	7	0
409	7x36	7x37	5ht2c_on	0	1.965	No	No	No	Yes	5	6
410	2x37	4x39	5ht2c_on	0	1.81	No	No	No	Yes	7	4
411	4x54	4x55	5ht2c_on	0	1.76	No	No	No	No	4	4
412	6x41	6x42	5ht2c_on	0	1.61	Yes	No	No	No	8	6
413	6x36	6x40	5ht2c_on	0	1.6	No	No	No	No	8	8
414	5x65	6x33	5ht2c_on	0	1.58	No	Yes	No	No	8	8
415	1x40	1x41	5ht2c_on	0	1.54	No	No	No	No	4	4
416	1x40	1x43	5ht2c_on	0	1.54	No	No	No	Yes	4	7
417	6x39	6x43	5ht2c_on	0	1.54	No	No	No	No	6	6
418	6x39	7x52	5ht2c_on	0	1.54	No	No	No	No	6	8
419	3x54	5x61	5ht2c_on	0	1.52	No	No	No	No	9	9
420	3x24	E1x49	5ht2c_on	0	1.49	No	No	No	Yes	5	3
421	I1x48	I1x49	5ht2c_on	0	1.44	No	No	No	No	6	5
422	2x43	3x46	5ht2c_on	0	1.43	No	No	No	Yes	8	9
423	3x52	I2x53	5ht2c_on	0	1.38	No	No	No	Yes	5	8
424	E1x49	E1x50	5ht2c_on	0	1.23	No	Yes	Yes	No	3	7
425	6x28	6x31	5ht2c_on	0	1.21	No	No	No	No	5	5
426	2x65	2x66	5ht2c_on	0	1.17	No	No	No	No	5	5
427	5x55	5x59	5ht2c_on	0	0.855	No	No	No	No	5	2
428	4x60	4x64	5ht2c_on	0	0.845	No	No	No	No	7	4
429	3x56	I2x50	5ht2c_on	0	0.815	No	No	No	No	5	9
430	1x38	1x39	5ht2c_on	0	0.775	No	No	No	No	3	7
431	1x41	1x44	5ht2c_on	0	0.735	No	No	No	No	4	4
432	5x65	6x30	5ht2c_on	0	0.665	No	Yes	No	No	8	7
433	4x39	4x43	5ht2c_on	0	0.625	No	Yes	No	No	4	4
434	6x32	7x56	5ht2c_on	0	0.62	No	No	Yes	No	8	7
435	7x55	8x51	5ht2c_on	0	0.605	No	No	No	No	5	9
436	2x66	E1.Y118	5ht2c_on	0	0.495	No	No	No	No	5	4

Orange: nodes, hubs and links specific of 5ht2c_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of 5ht2c_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	5ht2c_off Avg Int. Strength	5ht2c_on Avg Int. Strength	5ht2c_off Num Of Links	5ht2c_on Num Of Links	ConSurf
1	1x51	5ht2c_off	4.2425	2.94	4	1	4
2	I1x50	5ht2c_off	7.1325	5.65	4	3	8
3	2x40	5ht2c_off	6.5775	6.97667	4	3	9
4	E1x50	5ht2c_off	6.52429	1.23	7	1	7
5	E1x52	5ht2c_off	5.3625	0	4	0	6
6	3x26	5ht2c_off	5.395	1.76	4	2	6
7	3x50	5ht2c_off	5.18333	4.91	6	3	9
8	E2x50	5ht2c_off	6.6225	5.275	4	2	9
9	5x36	5ht2c_off	6.8875	6.33333	4	3	5
10	5x39	5ht2c_off	4.43	5.58333	4	3	7
11	5x48	5ht2c_off	4.6575	7.98333	4	3	6
12	5x50	5ht2c_off	3.895	3.09833	4	3	9
13	6x41	5ht2c_off	6.858	4.39167	5	3	8
14	6x44	5ht2c_off	9.2375	9.6675	4	2	9
15	6x47	5ht2c_off	4.3525	5.17167	4	3	8
16	7x35	5ht2c_off	6.9675	5.26	4	1	5
17	7x38	5ht2c_off	7.045	6.46	4	2	7
18	7x56	5ht2c_off	4.28	2.93	5	2	7
19	8x49	5ht2c_off	5.7075	9.205	4	1	6
20	8x54	5ht2c_off	6.115	4.735	4	2	7
21	8x57	5ht2c_off	5.01857	5.36	7	2	5
22	2x50	Shared	6.432	6.84	5	5	9
23	2x57	Shared	6.695	5.00375	4	4	8
24	3x25	Shared	5.755	4.155	6	4	9
25	3x35	Shared	6.646	4.86833	5	6	7
26	3x42	Shared	7.6025	8.287	4	5	8
27	3x51	Shared	5.6875	7.8375	4	4	8
28	4x50	Shared	5.076	4.04143	5	7	9
29	E2.F201	Shared	9.455	4.995	4	5	4
30	5x47	Shared	11.7925	10.0538	4	4	8
31	5x58	Shared	4.746	6.2925	5	4	9
32	6x48	Shared	9.32	5.857	5	5	8
33	6x51	Shared	6.90333	5.18125	6	4	7
34	6x52	Shared	12.342	8.6725	5	4	7
35	7x39	Shared	6.665	4.419	6	5	7
36	7x42	Shared	6.514	5.777	5	5	8
37	7x53	Shared	7.63	4.94083	4	6	9
38	8x50	Shared	5.64857	4.246	7	5	8
39	Lig	Shared	7.48467	7.68333	15	9	0
40	1x43	5ht2c_on	3.03	3.76	2	4	7
41	1x50	5ht2c_on	7.06333	4.8925	3	4	9
42	1x52	5ht2c_on	4.53333	3.07375	3	4	7
43	I1x51	5ht2c_on	5.44	4.0375	1	4	8
44	2x53	5ht2c_on	8.08	3.11875	1	4	7
45	E1x49	5ht2c_on	1.59	3.30875	1	4	3
46	3x46	5ht2c_on	3.97	4.5325	3	4	9
47	I2x53	5ht2c_on	1.31	7.44125	1	4	8
48	4x39	5ht2c_on	5.925	4.21	2	4	4
49	4x61	5ht2c_on	4.76	5.222	3	5	6
50	E2.K199	5ht2c_on	9.28667	7.0775	3	4	3
51	5x65	5ht2c_on	3.245	2.40875	2	4	8
52	7x37	5ht2c_on	8.80667	4.18625	3	4	6

Orange: nodes, hubs and links specific of 5ht2c_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of 5ht2c_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	5ht2c_off Recurrence	5ht2c_on Recurrence	5ht2c_off Hub1?	5ht2c_on Hub1?	5ht2c_off Hub2?	5ht2c_on Hub2?	ConSurf1	ConSurf2
1	1x33	NT.V52	5ht2c_off	15.1561	0	No	No	No	No	4	3
2	2x65	NT.V52	5ht2c_off	17.2965	0	No	No	No	No	5	3
3	2x61	2x65	5ht2c_off	19.4305	7.89091	No	No	No	No	6	5
4	1x39	2x61	5ht2c_off	21.5582	9.64374	No	No	No	No	7	6
5	2x56	3x28	5ht2c_off	61.3915	0	No	No	No	No	7	5
6	3x28	E1x50	5ht2c_off	58.0547	0	No	No	Yes	No	5	7
7	E1x50	E1x51	5ht2c_off	11.8603	0	Yes	No	No	No	7	3
8	E1x50	E1x52	5ht2c_off	13.5335	0	Yes	No	Yes	No	7	6
9	2x64	7x39	5ht2c_off	12.8516	1.7908	No	No	Yes	Yes	6	7
10	1x35	2x64	5ht2c_off	14.8815	0	No	No	No	No	6	6
11	1x32	1x35	5ht2c_off	11.9172	0	No	No	No	No	4	6
12	2x57	7x39	5ht2c_off	13.0094	0	Yes	Yes	Yes	Yes	8	7
13	1x56	8x57	5ht2c_off	12.5675	0	No	No	Yes	No	7	5
14	7x53	8x50	5ht2c_off	43.3248	0	Yes	Yes	Yes	Yes	9	8
15	7x49	7x53	5ht2c_off	53.8119	1.85408	No	No	Yes	Yes	9	9
16	2x50	7x49	5ht2c_off	63.0742	0	Yes	Yes	No	No	9	9
17	2x46	2x50	5ht2c_off	77.1822	9.05524	No	No	Yes	Yes	9	9
18	3x33	4x57	5ht2c_off	90.8672	0	No	No	No	No	6	8
19	7x42	Lig	5ht2c_off	51.359	0	Yes	Yes	Yes	Yes	8	0
20	1x50	2x50	5ht2c_off	11.3458	8.2073	No	Yes	Yes	Yes	9	9
21	1x53	8x54	5ht2c_off	11.7877	0	No	No	Yes	No	9	7
22	4x38	I2x57	5ht2c_off	14.5468	0	No	No	No	No	8	6
23	4x38	4x41	5ht2c_off	20.6869	0	No	No	No	No	8	7
24	4x41	4x45	5ht2c_off	24.5067	0.00632791	No	No	No	No	7	6
25	2x42	4x45	5ht2c_off	28.0803	0	No	No	No	No	8	6
26	3x46	6x37	5ht2c_off	35.7988	0	No	Yes	No	No	9	8
27	6x37	6x41	5ht2c_off	58.8566	0	No	No	Yes	No	8	8
28	3x43	6x41	5ht2c_off	96.1928	0	No	No	Yes	No	9	8
29	3x43	6x44	5ht2c_off	97.9701	0	No	No	Yes	No	9	9
30	3x40	6x44	5ht2c_off	52.5744	0	No	No	Yes	No	8	9
31	3x40	Lig	5ht2c_off	58.7998	0	No	No	Yes	Yes	8	0
32	6x44	6x48	5ht2c_off	61.0948	6.16339	Yes	No	Yes	Yes	9	8
33	6x48	Lig	5ht2c_off	52.5744	0	Yes	Yes	Yes	Yes	8	0
34	7x35	Lig	5ht2c_off	13.1262	0	Yes	No	Yes	Yes	5	0
35	3x25	E1x50	5ht2c_off	16.8419	0	Yes	Yes	Yes	No	9	7
36	3x47	6x41	5ht2c_off	21.5203	0	No	No	Yes	No	8	8
37	3x47	5x57	5ht2c_off	19.5094	0	No	No	No	No	8	6
38	3x50	5x65	5ht2c_off	14.3637	0	Yes	No	No	Yes	9	8
39	5x58	6x41	5ht2c_off	11.8098	7.35936	Yes	Yes	Yes	No	9	8
40	3x51	5x57	5ht2c_off	17.5459	7.38467	Yes	Yes	No	No	8	6
41	3x54	5x65	5ht2c_off	12.5485	0	No	No	No	Yes	9	8
42	5x47	Lig	5ht2c_off	11.2511	0	Yes	Yes	Yes	Yes	8	0
43	6x40	7x49	5ht2c_off	11.0648	0	No	No	No	No	8	9
44	6x44	7x45	5ht2c_off	16.4094	0	Yes	No	No	No	9	9
45	6x47	7x45	5ht2c_off	14.3543	8.19465	Yes	No	No	No	8	9
46	7x38	7x39	5ht2c_off	27.0007	0	Yes	No	Yes	Yes	7	7
47	7x38	Lig	5ht2c_off	21.9465	0	Yes	No	Yes	Yes	7	0
48	1x39	7x39	Shared	23.364	13.2949	No	No	Yes	Yes	7	7
49	7x39	7x42	Shared	24.1405	24.179	Yes	Yes	Yes	Yes	7	8
50	2x56	7x42	Shared	33.7122	33.0254	No	No	Yes	Yes	7	8
51	1x56	8x50	Shared	13.7797	20.996	No	No	Yes	Yes	7	8
52	2x46	3x42	Shared	78.0377	10.1183	No	No	Yes	Yes	9	8
53	3x42	4x50	Shared	80.0865	92.223	Yes	Yes	Yes	Yes	8	9
54	3x35	4x50	Shared	85.4532	99.0128	Yes	Yes	Yes	Yes	7	9
55	3x34	3x35	Shared	88.5848	34.1138	No	No	Yes	Yes	6	7
56	3x34	4x57	Shared	90.1127	32.1205	No	No	No	No	6	8
57	3x33	Lig	Shared	100	21.9958	No	No	Yes	Yes	6	0
58	3x32	Lig	Shared	30.287	72.3723	No	No	Yes	Yes	8	0
59	2x56	3x32	Shared	29.4977	54.9832	No	No	No	No	7	8
60	2x42	3x46	Shared	32.0737	97.9561	No	No	No	Yes	8	9
61	3x33	4x61	Shared	19.178	20.7682	No	No	No	Yes	6	6
62	3x50	6x37	Shared	23.4176	83.0665	Yes	No	No	No	9	8
63	3x51	3x55	Shared	10.1683	12.795	Yes	Yes	No	No	8	6
64	4x61	5x39	Shared	15.8001	19.5596	No	Yes	Yes	No	6	7
65	6x51	7x34	Shared	10.3229	57.1157	Yes	Yes	No	No	7	4
66	2x57	7x42	5ht2c_on	0	17.4714	Yes	Yes	Yes	Yes	8	8
67	1x43	2x57	5ht2c_on	4.35963	19.1293	No	Yes	Yes	Yes	7	8
68	1x46	2x57	5ht2c_on	4.35963	13.0292	No	No	Yes	Yes	7	8
69	2x53	2x56	5ht2c_on	0	87.8694	No	Yes	No	No	7	7
70	2x53	3x35	5ht2c_on	0	96.3172	No	Yes	Yes	Yes	7	7
71	2x52	3x35	5ht2c_on	1.30694	71.4231	No	No	Yes	Yes	6	7
72	2x48	2x52	5ht2c_on	0	70.1829	No	No	No	No	6	6
73	1x54	2x48	5ht2c_on	1.30063	68.93	No	No	No	No	7	6
74	1x54	2x44	5ht2c_on	3.79455	65.0952	No	No	No	No	7	5
75	1x57	2x44	5ht2c_on	6.26953	63.779	No	No	No	No	8	5
76	1x57	I1x50	5ht2c_on	0	62.4628	No	No	Yes	No	8	8
77	8x50	I1x50	5ht2c_on	8.43198	33.038	Yes	Yes	Yes	No	8	8
78	1x56	8x54	5ht2c_on	0	19.3001	No	No	Yes	No	7	7
79	1x52	8x54	5ht2c_on	7.23869	17.5916	No	Yes	Yes	No	7	7
80	1x52	8x57	5ht2c_on	0.441961	10.7132	No	Yes	Yes	No	7	5
81	2x40	I1x50	5ht2c_on	0.157843	28.0896	Yes	No	Yes	No	9	8
82	2x39	2x40	5ht2c_on	0	28.8363	No	No	Yes	No	8	9
83	2x39	I1x51	5ht2c_on	0	27.2164	No	No	No	Yes	8	8
84	2x37	I1x51	5ht2c_on	0	10.7385	No	No	No	Yes	7	8
85	2x42	3x42	5ht2c_on	0	100	No	No	Yes	Yes	8	8
86	3x32	7x42	5ht2c_on	0.0820785	17.8067	No	No	Yes	Yes	8	8
87	3x29	4x61	5ht2c_on	0	52.933	No	No	No	Yes	5	6
88	3x25	3x29	5ht2c_on	5.48347	49.1426	Yes	Yes	No	No	9	5
89	3x25	E2.F201	5ht2c_on	0.53351	43.2133	Yes	Yes	Yes	Yes	9	4
90	5x39	Lig	5ht2c_on	0	20.281	Yes	No	Yes	Yes	7	0
91	3x30	4x61	5ht2c_on	0	31.2599	No	No	No	Yes	6	6
92	6x52	Lig	5ht2c_on	0.839726	39.0685	Yes	Yes	Yes	Yes	7	0
93	5x47	6x52	5ht2c_on	2.14667	46.1621	Yes	Yes	Yes	Yes	8	7
94	5x47	6x48	5ht2c_on	0	33.4493	Yes	Yes	Yes	Yes	8	8
95	3x40	6x48	5ht2c_on	0	14.2125	No	No	Yes	Yes	8	8
96	7x38	7x42	5ht2c_on	1.34482	30.8486	Yes	No	Yes	Yes	7	8
97	6x51	7x38	5ht2c_on	7.3113	30.4879	Yes	Yes	Yes	No	7	7
98	3x40	5x50	5ht2c_on	8.68454	12.2192	No	No	Yes	No	8	9
99	3x46	7x53	5ht2c_on	0	15.516	No	Yes	Yes	Yes	9	9
100	3x46	3x50	5ht2c_on	0	80.3139	No	Yes	Yes	No	9	9
101	5x61	6x37	5ht2c_on	0	33.2595	No	No	No	No	9	8
102	3x51	5x61	5ht2c_on	0.921804	26.6658	Yes	Yes	No	No	8	9
103	I1x51	I2x57	5ht2c_on	0	13.7885	No	Yes	No	No	8	6
104	I2x53	I2x57	5ht2c_on	0	12.2319	No	Yes	No	No	8	6
105	3x55	3x56	5ht2c_on	8.09736	11.0042	No	No	No	No	6	5
106	E2.F201	E2.V200	5ht2c_on	0	30.7157	Yes	Yes	No	No	4	3
107	E2.K199	E2.V200	5ht2c_on	0	26.4507	No	Yes	No	No	3	3
108	5x36	E2.K199	5ht2c_on	3.87032	13.3519	Yes	No	No	Yes	5	3
109	5x58	6x37	5ht2c_on	0	57.1221	Yes	Yes	No	No	9	8
110	5x58	5x62	5ht2c_on	3.89557	48.4655	Yes	Yes	No	No	9	5
111	5x62	5x66	5ht2c_on	0	23.3816	No	No	No	No	5	6
112	5x62	6x34	5ht2c_on	1.96041	23.5651	No	No	No	No	5	7
113	5x65	5x66	5ht2c_on	0	21.768	No	Yes	No	No	8	6
114	5x65	6x34	5ht2c_on	0	21.9389	No	Yes	No	No	8	7
115	5x65	6x30	5ht2c_on	0	37.2081	No	Yes	No	No	8	7
116	5x68	6x30	5ht2c_on	0	13.8265	No	No	No	No	7	7
117	5x68	5x71	5ht2c_on	0	10.3968	No	No	No	No	7	0
118	5x69	6x30	5ht2c_on	0	20.667	No	No	No	No	6	7
119	5x69	6x27	5ht2c_on	0.0126275	17.2625	No	No	No	No	6	4
120	6x48	7x45	5ht2c_on	0	10.2133	Yes	Yes	No	No	8	9
121	6x54	7x34	5ht2c_on	9.38852	50.3449	No	No	No	No	5	4
122	6x54	7x37	5ht2c_on	3.77561	27.0645	No	No	No	Yes	5	6
123	6x54	7x30	5ht2c_on	4.65006	21.749	No	No	No	No	5	4
124	7x27	7x30	5ht2c_on	0	16.3577	No	No	No	No	1	4
125	7x27	E3.E338	5ht2c_on	0	13.6936	No	No	No	No	1	1
126	E3.C341	E3.E338	5ht2c_on	0	10.9789	No	No	No	No	3	1
127	7x33	7x37	5ht2c_on	1.50267	19.085	No	No	No	Yes	5	6
128	7x29	7x33	5ht2c_on	0.391451	16.3956	No	No	No	No	4	5
129	7x26	7x29	5ht2c_on	1.38902	13.6936	No	No	No	No	4	4
130	7x26	7x28	5ht2c_on	2.65492	10.9789	No	No	No	No	4	1
131	8x47	8x50	5ht2c_on	6.13063	12.485	No	No	Yes	Yes	8	8
132	2x53	2x54	5ht2c_on	0	10.1753	No	Yes	No	No	7	6
133	3x30	4x57	5ht2c_on	0	31.9433	No	No	No	No	6	8
134	6x51	Lig	5ht2c_on	7.55753	31.2852	Yes	Yes	Yes	Yes	7	0

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
2x56	3x32	Shared	7.3	13.15	1	3	2	1
2x56	7x42	Shared	5.05	5.68	1	3	2	1
2x57	7x39	5ht2c_off	8.14	0	0	0	2	2
7x35	E1.Y118	5ht2c_off	15.12	0	0	0	1	2
3x32	7x42	Shared	8.05	10.34	1	3	1	1
3x32	Lig	Shared	14.95	13.165	1	3	1	0
3x33	4x57	5ht2c_off	3.23	0	0	0	1	2
3x33	4x61	Shared	4.61	3.84	0	0	1	2
3x33	Lig	Shared	6.91	19.225	0	0	1	0
3x36	Lig	Shared	12.19	9.87	0	0	1	0
3x37	5x461	5ht2c_off	5.03	0	0	0	1	1
3x37	Lig	5ht2c_off	4.27	0	0	0	1	0
3x40	5x50	Shared	3.39	3.39	0	0	1	2
3x40	6x44	5ht2c_off	7.54	0	0	0	1	2
3x40	Lig	5ht2c_off	4.96	0	0	0	1	0
4x61	5x39	Shared	6.28	4.395	0	2	2	1
4x64	5x39	5ht2c_off	3.77	0	0	0	2	1
E2.T206	E2x51	5ht2c_off	4.76	0	0	2	2	1
E2x51	Lig	5ht2c_off	3.45	0	0	0	1	0
5x36	5x39	5ht2c_off	4.78	0	0	0	2	1
5x44	5x48	5ht2c_off	3.96	0	1	3	1	2
5x44	6x52	Shared	3.96	3.96	1	3	1	1
5x44	Lig	Shared	5.22	7.865	1	3	1	0
5x47	5x48	Shared	4.29	9.65	1	0	1	2
5x47	5x51	Shared	3.65	2.44	1	0	1	2
5x47	6x52	Shared	34.29	24.115	1	0	1	1
5x47	Lig	5ht2c_off	4.94	0	1	0	1	0
6x44	6x48	Shared	10.02	7.515	0	0	2	1
6x44	7x45	5ht2c_off	12.08	0	0	0	2	2
6x48	6x51	5ht2c_off	7.02	0	1	0	1	1
6x48	6x52	5ht2c_off	5.01	0	1	0	1	1
6x48	7x41	Shared	12.67	6.335	1	0	1	2
6x48	Lig	5ht2c_off	11.88	0	1	0	1	0
6x51	6x52	Shared	8.57	3.755	1	3	1	1
6x51	6x55	5ht2c_off	7.25	0	1	3	1	2
6x51	7x34	Shared	4.87	3.045	1	3	1	2
6x51	7x38	Shared	5.24	7.87	1	3	1	1
6x51	Lig	Shared	8.47	6.055	1	3	1	0
6x52	Lig	Shared	9.88	2.86	1	3	1	0
6x55	7x34	Shared	5.49	2.75	1	0	2	2
7x31	7x35	Shared	6.57	5.26	0	10	2	1
7x35	Lig	5ht2c_off	4.78	0	0	0	1	0
7x38	7x39	5ht2c_off	3.68	0	1	0	1	2
7x38	7x42	Shared	6.31	5.05	1	0	1	1
7x38	Lig	5ht2c_off	12.95	0	1	0	1	0
7x39	7x42	Shared	7.72	4.825	1	0	2	1
7x42	Lig	5ht2c_off	5.44	0	1	3	1	0
E2.V202	E2x51	Shared	3.21	3.21	0	0	2	1
4x60	5x39	5ht2c_off	2.89	0	0	0	2	1
5x43	Lig	Shared	1.98	1.74	0	0	1	0
5x42	5x43	Shared	1.76	2.645	0	0	2	1
4x56	5x461	5ht2c_off	1.7	0	0	0	2	1
7x32	7x35	5ht2c_off	1.4	0	0	10	2	1
2x57	7x42	5ht2c_on	0	2.99	0	0	2	1
3x33	4x56	5ht2c_on	0	3.21	0	0	1	2
3x37	4x56	5ht2c_on	0	4.76	0	0	1	2
3x40	6x48	5ht2c_on	0	2.935	0	0	1	1
5x39	E2x52	5ht2c_on	0	7.31	0	0	1	2
5x39	Lig	5ht2c_on	0	5.045	0	0	1	0
5x461	Lig	5ht2c_on	0	3.325	0	0	1	0
5x47	6x48	5ht2c_on	0	4.01	1	0	1	1
6x48	7x45	5ht2c_on	0	8.49	1	0	1	2
7x31	7x32	5ht2c_on	0	11.475	0	10	2	2
4x60	4x64	5ht2c_on	0	0.845	0	0	2	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	5ht2c_off	6BQH-5-HT_2C-Ritanserin
	5ht2c_on	8DPF-5-HT_2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT_2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2

Network Difference
Value	5ht2c_off	5ht2c_on
I_min	3.23	2.715
Number of Linked Nodes	275	256
Number of Specific Nodes	31 (11.27%)	12 (4.69%)
Number of Shared Nodes	244 (88.73%)	244 (95.31%)
Number of Links	306	278
Number of Specific Links	158 (51.63%)	130 (46.76%)
Number of Shared Links	148 (48.37%)	148 (53.24%)
Number of Hubs	39	31
Number of Specific Hubs	21 (53.85%)	13 (41.94%)
Number of Shared Hubs	18 (46.15%)	18 (58.06%)
Average % Shared Neighbours (Jaccard)	36.76
Average % Shared Neighbours (Otsuka)	44.58
Average % Shared Neighbours (Overlap Coefficient)	52.19
Average % Shared Cliques (k3-6)	54.05
Graphlets Similarity	0.529637

Paths Difference
Value	5ht2c_off	5ht2c_on
Number Of Nodes in MetaPath	65	83
Specific Nodes in MetaPath	27 (41.54%)	45 (54.22%)
Shared Nodes in MetaPath	244 (88.73%)	244 (88.73%)
Number Of Links MetaPath	65	87
Specific Links in MetaPath	47 (72.31%)	69 (79.31%)
Shared Links in MetaPath	148 (48.37%)	148 (48.37%)
Number of Shortest Paths	73126	41361
Length Of Smallest Path	3	3
Average Path Length	14.153	14.879
Length of Longest Path	32	30
Minimum Path Strength	1.38	0.8325
Average Path Strength	6.26086	5.64522
Maximum Path Strength	21.43	17.03
Minimum Path Correlation	0.7	0.7
Average Path Correlation	0.922597	0.918967
Maximum Path Correlation	0.99	0.99
Minimum % Of Corr. Nodes	3.7037	3.84615
Average % Of Corr. Nodes	47.8765	42.1392
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	42.6965	39.1705
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

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