psnGPCR

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Orange: nodes, hubs and links specific of 5ht5a_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of 5ht5a_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	5ht5a_off Int. Strength	5ht5a_on Int. Strength	5ht5a_off Hub1?	5ht5a_on Hub1?	5ht5a_off Hub2?	5ht5a_on Hub2?	ConSurf1	ConSurf2
1	1x28	NT.L35	5ht5a_off	6.92	0	No	No	No	No	6	2
2	1x28	1x29	5ht5a_off	6.01	0	No	No	No	No	6	3
3	1x36	2x66	5ht5a_off	4.5	0	No	No	No	No	5	3
4	1x39	2x61	5ht5a_off	4.15	0	No	No	No	No	6	6
5	1x46	2x57	5ht5a_off	4.52	0	No	No	Yes	Yes	7	7
6	1x49	7x54	5ht5a_off	8.49	0	Yes	No	No	No	8	7
7	1x57	2x40	5ht5a_off	11.93	0	Yes	No	No	No	7	9
8	2x39	2x42	5ht5a_off	6.57	0	No	No	Yes	Yes	8	8
9	2x39	3x49	5ht5a_off	6.44	0	No	No	Yes	No	8	9
10	2x42	3x46	5ht5a_off	4.28	0	Yes	Yes	No	No	8	9
11	2x43	7x53	5ht5a_off	12.62	0	No	No	No	Yes	8	9
12	2x46	3x46	5ht5a_off	4.37	0	Yes	No	No	No	9	9
13	2x49	3x42	5ht5a_off	4.47	0	No	No	Yes	No	8	7
14	2x53	2x56	5ht5a_off	4.81	0	No	No	No	No	7	7
15	2x53	7x46	5ht5a_off	8.08	0	No	No	No	No	7	9
16	2x57	7x39	5ht5a_off	4.65	0	Yes	Yes	Yes	Yes	7	6
17	2x59	E1x50	5ht5a_off	5.69	0	No	No	Yes	Yes	5	8
18	2x60	2x64	5ht5a_off	10.06	0	No	No	Yes	No	6	5
19	2x60	7x39	5ht5a_off	7.41	0	No	No	Yes	Yes	6	6
20	2x60	7x42	5ht5a_off	5.09	0	No	No	Yes	Yes	6	7
21	2x62	E1.R105	5ht5a_off	5.23	0	No	No	No	Yes	5	6
22	2x64	3x28	5ht5a_off	8.72	0	Yes	No	No	Yes	5	5
23	2x64	E2x51	5ht5a_off	6.37	0	Yes	No	No	No	5	4
24	2x64	Lig	5ht5a_off	8.9	0	Yes	No	Yes	Yes	5	0
25	2x65	7x35	5ht5a_off	4.5	0	No	No	No	No	5	5
26	2x65	7x39	5ht5a_off	9.11	0	No	No	Yes	Yes	5	6
27	E1x49	E2.E191	5ht5a_off	5.82	0	No	No	No	Yes	3	3
28	3x22	E1x50	5ht5a_off	8	0	No	No	Yes	Yes	4	8
29	3x24	E1x50	5ht5a_off	5.69	0	No	No	Yes	Yes	5	8
30	3x22	3x23	5ht5a_off	4.26	0	No	No	No	No	4	1
31	3x26	E2.E183	5ht5a_off	6.37	0	No	No	No	No	6	4
32	3x26	E2.T184	5ht5a_off	5.67	0	No	No	No	No	6	4
33	3x40	6x44	5ht5a_off	6.28	0	No	No	Yes	No	8	9
34	3x41	3x44	5ht5a_off	7.28	0	Yes	No	No	No	6	6
35	3x44	5x50	5ht5a_off	5.25	0	No	No	No	No	6	9
36	3x50	3x53	5ht5a_off	6.59	0	Yes	No	No	No	9	8
37	3x50	3x54	5ht5a_off	5.01	0	Yes	No	No	No	9	9
38	3x50	6x33	5ht5a_off	6.91	0	Yes	No	No	No	9	8
39	3x50	6x37	5ht5a_off	9.15	0	Yes	No	No	No	9	8
40	3x55	5x60	5ht5a_off	6.01	0	No	No	No	No	6	5
41	I2x54	I2x56	5ht5a_off	15.52	0	No	No	No	No	5	5
42	4x39	4x43	5ht5a_off	4.2	0	No	No	No	No	3	3
43	4x52	4x56	5ht5a_off	7.14	0	No	No	No	No	4	6
44	4x60	E2.T184	5ht5a_off	5.25	0	Yes	No	No	No	7	4
45	4x63	E2.W181	5ht5a_off	9.02	0	No	No	No	No	4	7
46	5x36	E2.W181	5ht5a_off	6.54	0	Yes	No	No	No	6	7
47	5x38	E2.W181	5ht5a_off	4.94	0	No	No	No	No	3	7
48	E2.E183	E2.Y185	5ht5a_off	15.71	0	No	No	No	No	4	4
49	E2.E187	E2.Y185	5ht5a_off	5.61	0	No	No	No	No	2	4
50	E2.R196	E2.S186	5ht5a_off	3.95	0	No	No	No	No	4	2
51	E2x52	Lig	5ht5a_off	11.01	0	No	No	Yes	Yes	4	0
52	5x39	Lig	5ht5a_off	5.51	0	Yes	Yes	Yes	Yes	7	0
53	5x44	Lig	5ht5a_off	3.96	0	Yes	No	Yes	Yes	6	0
54	5x461	Lig	5ht5a_off	4.24	0	No	No	Yes	Yes	7	0
55	5x47	5x48	5ht5a_off	8.25	0	No	Yes	No	No	8	5
56	5x51	6x45	5ht5a_off	4.47	0	No	No	No	No	5	5
57	5x54	6x41	5ht5a_off	6.14	0	No	No	Yes	No	8	8
58	5x58	6x41	5ht5a_off	6.04	0	No	No	Yes	No	9	8
59	5x61	6x37	5ht5a_off	4.61	0	No	No	No	No	9	8
60	5x66	5x68	5ht5a_off	11.14	0	No	No	No	No	5	7
61	5x67	6x31	5ht5a_off	16.4	0	No	No	No	No	5	5
62	6x35	6x39	5ht5a_off	5.71	0	Yes	No	No	No	6	7
63	6x35	7x56	5ht5a_off	4.87	0	Yes	No	No	Yes	6	6
64	6x36	7x53	5ht5a_off	4.79	0	No	No	No	Yes	8	9
65	6x40	7x49	5ht5a_off	4.12	0	No	No	Yes	No	8	9
66	6x43	7x52	5ht5a_off	4.61	0	No	No	No	No	5	8
67	6x44	6x45	5ht5a_off	6.55	0	Yes	No	No	No	9	5
68	6x44	6x48	5ht5a_off	4.01	0	Yes	No	Yes	Yes	9	8
69	6x48	6x51	5ht5a_off	7.02	0	Yes	Yes	Yes	No	8	7
70	6x51	6x55	5ht5a_off	13.99	0	Yes	No	No	No	7	7
71	6x51	7x34	5ht5a_off	4.96	0	Yes	No	No	No	7	4
72	6x51	7x38	5ht5a_off	6.09	0	Yes	No	Yes	No	7	5
73	6x55	7x34	5ht5a_off	5.4	0	No	No	No	No	7	4
74	6x57	E3.S312	5ht5a_off	4.64	0	No	No	No	No	5	1
75	6x58	E3.I315	5ht5a_off	6.19	0	No	No	No	No	3	4
76	E3.I315	E3.S312	5ht5a_off	7.74	0	No	No	No	No	4	1
77	7x33	7x36	5ht5a_off	4.7	0	No	No	No	No	4	3
78	7x38	7x39	5ht5a_off	4.56	0	Yes	No	Yes	Yes	5	6
79	1x53	7x53	5ht5a_off	3.79	0	No	No	No	Yes	9	9
80	2x66	2x67	5ht5a_off	3.71	0	No	No	No	No	3	4
81	3x52	4x41	5ht5a_off	3.68	0	Yes	No	No	No	4	6
82	1x43	2x58	5ht5a_off	3.53	0	No	No	No	No	6	9
83	3x41	5x49	5ht5a_off	3.42	0	Yes	No	No	No	6	6
84	3x47	6x41	5ht5a_off	3.25	0	No	No	Yes	No	8	8
85	2x55	2x551	5ht5a_off	3.15	0	No	No	No	No	4	5
86	5x65	6x35	5ht5a_off	3.15	0	No	No	Yes	No	8	6
87	I2x54	I2x57	5ht5a_off	3.14	0	No	No	No	No	5	7
88	1x57	2x43	5ht5a_off	3.07	0	Yes	No	No	No	7	8
89	1x56	1x57	5ht5a_off	3.04	0	No	No	Yes	No	7	7
90	6x54	6x57	5ht5a_off	3.04	0	No	No	No	No	5	5
91	3x21	3x23	5ht5a_off	3	0	No	No	No	No	7	1
92	7x40	7x43	5ht5a_off	3	0	No	No	No	No	8	4
93	2x48	2x52	5ht5a_off	2.98	0	No	No	No	No	6	6
94	4x52	4x55	5ht5a_off	2.98	0	No	No	No	No	4	5
95	5x58	5x62	5ht5a_off	2.98	0	No	No	No	No	9	6
96	5x60	5x63	5ht5a_off	2.87	0	No	No	No	No	5	4
97	2x42	4x45	5ht5a_off	2.83	0	Yes	Yes	No	No	8	5
98	2x52	2x551	5ht5a_off	2.77	0	No	No	No	No	6	5
99	4x59	5x42	5ht5a_off	2.77	0	No	No	No	No	7	4
100	1x30	1x31	5ht5a_off	2.62	0	No	No	No	No	2	2
101	2x48	4x50	5ht5a_off	2.45	0	No	No	No	No	6	9
102	6x31	6x32	5ht5a_off	2.34	0	No	No	No	No	5	8
103	1x49	1x52	5ht5a_off	2.28	0	Yes	No	No	No	8	6
104	5x40	Lig	5ht5a_off	2.12	0	No	No	Yes	Yes	6	0
105	5x64	6x34	5ht5a_off	1.79	0	No	No	No	No	6	7
106	5x65	6x34	5ht5a_off	1.79	0	No	No	No	No	8	7
107	4x56	5x46	5ht5a_off	1.76	0	No	No	No	No	6	5
108	5x61	6x38	5ht5a_off	1.76	0	No	No	No	No	9	6
109	E2.E187	E2.G188	5ht5a_off	1.64	0	No	No	No	No	2	4
110	6x50	7x40	5ht5a_off	1.64	0	No	No	No	No	9	8
111	4x39	4x40	5ht5a_off	1.62	0	No	No	No	No	3	5
112	5x41	5x45	5ht5a_off	1.6	0	No	No	No	No	6	4
113	1x33	1x37	5ht5a_off	1.59	0	No	No	No	No	6	4
114	4x41	I2x57	5ht5a_off	1.59	0	No	No	No	No	6	7
115	5x44	5x45	5ht5a_off	1.59	0	Yes	No	No	No	6	4
116	1x54	2x44	5ht5a_off	1.58	0	No	No	No	No	7	5
117	4x54	4x58	5ht5a_off	1.58	0	No	No	No	No	4	4
118	2x46	3x43	5ht5a_off	1.52	0	Yes	No	No	No	9	8
119	1x31	1x32	5ht5a_off	1.51	0	No	No	No	No	2	3
120	1x30	NT.L35	5ht5a_off	1.49	0	No	No	No	No	2	2
121	1x30	1x34	5ht5a_off	1.49	0	No	No	No	No	2	4
122	1x51	2x51	5ht5a_off	1.49	0	No	No	No	No	4	7
123	6x53	6x57	5ht5a_off	1.43	0	No	No	No	No	5	5
124	1x36	2x61	5ht5a_off	1.38	0	No	No	No	No	5	6
125	I2x51	I2x52	5ht5a_off	1.35	0	No	No	No	No	7	5
126	2x66	E1.R105	5ht5a_off	1.32	0	No	No	No	Yes	3	6
127	6x58	E2.R196	5ht5a_off	1.32	0	No	No	No	No	3	4
128	6x27	6x28	5ht5a_off	1.27	0	No	No	No	No	4	5
129	5x67	6x27	5ht5a_off	1.17	0	No	No	No	No	5	4
130	6x28	6x32	5ht5a_off	1.17	0	No	No	No	No	5	8
131	5x36	5x39	5ht5a_off	1.12	0	Yes	No	Yes	Yes	6	7
132	1x39	7x39	Shared	4.56	4.93667	No	No	Yes	Yes	6	6
133	1x42	7x47	Shared	4.87	1.62333	No	No	Yes	Yes	7	6
134	1x43	2x57	Shared	9.13	2.53333	No	No	Yes	Yes	6	7
135	1x46	7x47	Shared	6.49	4.75667	No	No	Yes	Yes	7	6
136	1x49	7x47	Shared	6.01	6.34667	Yes	No	Yes	Yes	8	6
137	1x49	7x50	Shared	9.46	4.95333	Yes	No	No	No	8	9
138	1x49	7x51	Shared	7.97	6.07333	Yes	No	No	No	8	6
139	1x50	2x50	Shared	10.9	10.77	No	No	Yes	Yes	9	9
140	1x50	7x50	Shared	16.29	8.69	No	No	No	No	9	9
141	1x54	2x47	Shared	4.73	2.62667	No	No	No	No	7	9
142	1x54	2x48	Shared	4.47	1.98667	No	No	No	No	7	6
143	1x57	1x58	Shared	4.28	0.95	Yes	No	No	No	7	4
144	2x39	4x38	Shared	8.65	4.80333	No	No	Yes	Yes	8	8
145	2x41	4x42	Shared	8.94	6.45667	No	Yes	No	No	4	7
146	2x41	4x43	Shared	4.09	4.09	No	Yes	No	No	4	3
147	2x41	4x46	Shared	5.66	3.30333	No	Yes	No	No	4	8
148	2x42	3x49	Shared	4.07	3.61667	Yes	Yes	Yes	No	8	9
149	2x42	4x46	Shared	5.71	3.32667	Yes	Yes	No	No	8	8
150	2x45	3x42	Shared	8.94	5.46333	No	No	Yes	No	9	7
151	2x45	4x46	Shared	7.74	6.19	No	No	No	No	9	8
152	2x45	4x50	Shared	6.18	2.88333	No	No	No	No	9	9
153	2x46	3x42	Shared	5.61	3.73667	Yes	No	Yes	No	9	7
154	2x46	7x49	Shared	9.82	6.07667	Yes	No	Yes	No	9	9
155	2x50	3x39	Shared	4.47	3.92667	Yes	Yes	No	No	9	9
156	2x50	7x46	Shared	8.94	7.36333	Yes	Yes	No	No	9	9
157	2x50	7x49	Shared	4.09	4.49	Yes	Yes	Yes	No	9	9
158	2x52	3x35	Shared	6.35	4.76	No	No	No	No	6	6
159	2x551	3x31	Shared	7.94	1.06	No	No	No	No	5	5
160	2x56	3x32	Shared	10.22	6.81333	No	No	No	No	7	8
161	2x56	7x42	Shared	5.05	4.21	No	No	Yes	Yes	7	7
162	2x57	7x42	Shared	5.99	5.58667	Yes	Yes	Yes	Yes	7	7
163	2x59	3x28	Shared	19.36	7.21333	No	No	No	Yes	5	5
164	2x61	7x39	Shared	7.97	2.28	No	No	Yes	Yes	6	6
165	2x63	E1x50	Shared	6.35	8.46333	No	Yes	Yes	Yes	5	8
166	2x63	E2.E191	Shared	6.15	6.15333	No	Yes	No	Yes	5	3
167	E1x50	E1x52	Shared	7.97	4.17667	Yes	Yes	No	No	8	6
168	3x25	E1x50	Shared	5.22	5.66	No	No	Yes	Yes	9	8
169	E1x50	E2x50	Shared	16.98	4.78667	Yes	Yes	No	No	8	9
170	3x25	E2x50	Shared	7.28	7.28	No	No	No	No	9	9
171	3x26	E2.Y185	Shared	6.76	3.00667	No	No	No	No	6	4
172	3x29	E2x52	Shared	4.61	3.07333	No	No	No	No	6	4
173	3x32	7x42	Shared	8.05	9.19667	No	No	Yes	Yes	8	7
174	3x32	Lig	Shared	14.59	15.9067	No	No	Yes	Yes	8	0
175	3x33	4x57	Shared	6.46	4.84667	No	No	Yes	Yes	7	8
176	3x33	Lig	Shared	4	8.47	No	No	Yes	Yes	7	0
177	3x34	4x57	Shared	4.5	3.5	No	No	Yes	Yes	5	8
178	3x36	6x48	Shared	5.22	3.48	No	No	Yes	Yes	6	8
179	3x36	Lig	Shared	4.27	6.30667	No	No	Yes	Yes	6	0
180	3x37	4x53	Shared	6.4	5.86333	No	No	No	No	7	8
181	3x37	5x461	Shared	5.03	3.36	No	No	No	No	7	7
182	3x37	Lig	Shared	3.96	4.35333	No	No	Yes	Yes	7	0
183	3x38	4x50	Shared	6.48	6.91333	No	No	No	No	8	9
184	3x40	6x48	Shared	8.22	6.65333	No	No	Yes	Yes	8	8
185	3x41	4x52	Shared	5.69	4.93667	Yes	No	No	No	6	4
186	3x41	5x50	Shared	20.27	9.91	Yes	No	No	No	6	9
187	3x42	4x49	Shared	7.31	7.31	Yes	No	No	No	7	6
188	3x45	4x45	Shared	4.83	3.75667	No	No	No	No	7	5
189	3x48	3x52	Shared	9.11	4.17667	No	No	Yes	No	6	4
190	3x48	5x53	Shared	4.47	3.47667	No	No	No	No	6	6
191	3x49	I2x53	Shared	6.9	8.81333	Yes	No	No	Yes	9	8
192	3x49	4x38	Shared	13.1	10.72	Yes	No	Yes	Yes	9	8
193	3x51	3x55	Shared	12.48	4.16	Yes	Yes	No	No	8	6
194	3x51	5x57	Shared	11.36	8.41333	Yes	Yes	No	No	8	6
195	3x52	I2x53	Shared	9.65	8.68333	Yes	No	No	Yes	4	8
196	3x53	4x38	Shared	3.95	2.63667	No	No	Yes	Yes	8	8
197	3x54	5x64	Shared	4.87	1.08	No	No	No	No	9	6
198	3x55	3x56	Shared	6.47	4.31333	No	No	No	No	6	5
199	3x56	I2x52	Shared	11.63	3.87667	No	No	No	No	5	5
200	I2x50	I2x51	Shared	10.51	2.23667	No	No	No	No	8	7
201	4x38	I2x53	Shared	10.29	12.69	Yes	Yes	No	Yes	8	8
202	4x57	4x58	Shared	6.01	2.00333	Yes	Yes	No	No	8	4
203	4x60	5x39	Shared	12.52	11.1267	Yes	No	Yes	Yes	7	7
204	E2.E191	E2.S189	Shared	4.31	0.956667	No	Yes	No	No	3	3
205	5x36	5x37	Shared	4.72	2.62	Yes	No	No	No	6	4
206	5x36	5x38	Shared	8.62	4.31333	Yes	No	No	No	6	3
207	5x39	5x43	Shared	5.09	10.5967	Yes	Yes	No	No	7	6
208	5x43	Lig	Shared	15.13	6.19333	No	No	Yes	Yes	6	0
209	5x44	5x48	Shared	4.99	4.57667	Yes	No	No	No	6	5
210	5x44	6x52	Shared	5.19	5.62333	Yes	No	Yes	Yes	6	6
211	5x47	6x44	Shared	4.29	4.28667	No	Yes	Yes	No	8	9
212	5x47	6x52	Shared	22.51	16.08	No	Yes	Yes	Yes	8	6
213	5x48	6x56	Shared	7.03	4.3	No	No	No	No	5	5
214	5x51	5x55	Shared	4.15	2.30667	No	No	No	No	5	4
215	5x59	5x63	Shared	10.44	2.32	No	No	No	No	1	4
216	5x62	5x66	Shared	5.97	5.57333	No	No	No	No	6	5
217	6x29	6x32	Shared	7.43	4.12667	No	Yes	No	No	5	8
218	6x36	7x56	Shared	14.93	1.24333	No	No	No	Yes	8	6
219	6x39	7x52	Shared	4.42	2.94	No	No	No	No	7	8
220	6x40	7x52	Shared	8.56	3.80333	No	No	No	No	8	8
221	6x47	7x45	Shared	7.87	7.87333	No	No	No	No	8	9
222	6x48	6x52	Shared	8.02	5.34333	Yes	Yes	Yes	Yes	8	6
223	6x48	7x41	Shared	11.26	8.44	Yes	Yes	No	No	8	7
224	6x48	7x45	Shared	6.78	5.65	Yes	Yes	No	No	8	9
225	6x50	7x37	Shared	10.11	6.74	No	No	No	No	9	5
226	6x51	6x52	Shared	9.65	6.07667	Yes	No	Yes	Yes	7	6
227	6x51	Lig	Shared	9	10.0733	Yes	No	Yes	Yes	7	0
228	6x52	Lig	Shared	7.37	5.89333	Yes	Yes	Yes	Yes	6	0
229	6x54	7x37	Shared	9.08	2.59	No	No	No	No	5	5
230	6x55	Lig	Shared	12.47	4.86667	No	No	Yes	Yes	7	0
231	7x38	7x42	Shared	15.24	4.68667	Yes	No	Yes	Yes	5	7
232	7x38	Lig	Shared	10.23	5.42333	Yes	No	Yes	Yes	5	0
233	7x39	7x42	Shared	8.68	5.14333	Yes	Yes	Yes	Yes	6	7
234	7x43	7x48	Shared	7.93	3.08	No	No	No	No	4	6
235	7x45	7x49	Shared	12.26	9.08333	No	No	Yes	No	9	9
236	7x47	7x48	Shared	5.36	3.21667	Yes	Yes	No	No	6	6
237	1x47	2x51	Shared	3.93	3.05667	No	Yes	No	No	6	7
238	3x51	3x52	Shared	3.86	4.5	Yes	Yes	Yes	No	8	4
239	4x59	4x60	Shared	3.74	1.87	No	No	Yes	No	7	7
240	1x40	1x43	Shared	3.68	1.22667	No	No	No	No	3	6
241	6x58	6x59	Shared	3.56	2.37333	No	No	No	No	3	5
242	1x32	1x35	Shared	3.53	2.94	No	No	No	No	3	4
243	7x32	7x33	Shared	3.52	3.13	No	No	No	No	1	4
244	3x40	5x50	Shared	3.39	3.39	No	No	No	No	8	9
245	7x30	E3.I315	Shared	3.39	3.95	No	No	No	No	5	4
246	1x46	2x54	Shared	3.36	3.36	No	No	No	No	7	7
247	3x44	5x54	Shared	3.17	3.17333	No	No	No	No	6	8
248	4x44	4x48	Shared	2.98	1.98667	No	No	No	No	3	3
249	3x48	4x45	Shared	2.83	2.82667	No	No	No	No	6	5
250	1x45	7x47	Shared	2.77	2.31333	No	No	Yes	Yes	4	6
251	1x47	2x55	Shared	2.77	3.23333	No	Yes	No	No	6	4
252	7x55	7x56	Shared	2.77	2.77667	No	No	No	Yes	6	6
253	7x30	7x33	Shared	2.7	5.40333	No	No	No	No	5	4
254	6x31	6x35	Shared	2.66	0.886667	No	No	Yes	No	5	6
255	6x49	6x50	Shared	1.87	3.39	No	Yes	No	No	6	9
256	6x41	6x42	Shared	1.76	2.35	Yes	No	No	No	8	5
257	3x30	4x57	Shared	1.71	1.14	No	No	Yes	Yes	6	8
258	4x40	4x44	Shared	1.71	0.57	No	No	No	No	5	3
259	4x60	4x61	Shared	1.64	2.73333	Yes	No	No	No	7	6
260	3x34	4x54	Shared	1.58	1.58	No	No	No	No	5	4
261	1x33	1x34	Shared	1.49	0.496667	No	No	No	No	6	4
262	5x36	E2.S195	Shared	1.44	6.71	Yes	No	No	No	6	3
263	6x27	6x30	Shared	1.27	1.69	No	No	No	No	4	7
264	3x51	5x56	Shared	1.03	1.71667	Yes	Yes	No	No	8	4
265	1x52	8x54	5ht5a_on	0	4.87333	No	No	No	No	6	0
266	1x55	1x59	5ht5a_on	0	3.22667	No	No	No	No	5	0
267	1x59	8x57	5ht5a_on	0	11.0467	No	No	No	No	0	0
268	1x60	I1x49	5ht5a_on	0	4.23	No	No	No	No	0	0
269	I1x49	I1x50	5ht5a_on	0	6.05333	No	No	No	Yes	0	0
270	8x49	I1x50	5ht5a_on	0	4.83333	No	No	No	Yes	0	0
271	8x50	I1x50	5ht5a_on	0	9.97	No	Yes	No	Yes	0	0
272	2x37	2x40	5ht5a_on	0	5.26667	No	No	No	No	0	9
273	2x38	2x39	5ht5a_on	0	4.71	No	No	No	No	0	8
274	2x38	4x38	5ht5a_on	0	7.84667	No	No	Yes	Yes	0	8
275	2x38	4x39	5ht5a_on	0	3.03667	No	No	No	No	0	3
276	2x39	2x40	5ht5a_on	0	3.05333	No	No	No	No	8	9
277	2x40	8x50	5ht5a_on	0	7.62333	No	No	No	Yes	9	0
278	2x41	2x42	5ht5a_on	0	6.41	No	Yes	Yes	Yes	4	8
279	2x42	4x42	5ht5a_on	0	4	Yes	Yes	No	No	8	7
280	2x43	8x50	5ht5a_on	0	4.21	No	No	No	Yes	8	0
281	2x46	7x53	5ht5a_on	0	4.78667	Yes	No	No	Yes	9	9
282	2x49	3x39	5ht5a_on	0	4.89	No	No	No	No	8	9
283	2x53	2x57	5ht5a_on	0	4.05667	No	No	Yes	Yes	7	7
284	2x60	3x28	5ht5a_on	0	3.29667	No	No	No	Yes	6	5
285	2x63	E1.R105	5ht5a_on	0	3.38667	No	Yes	No	Yes	5	6
286	2x63	3x28	5ht5a_on	0	5.64333	No	Yes	No	Yes	5	5
287	2x64	7x39	5ht5a_on	0	5.81333	Yes	No	Yes	Yes	5	6
288	3x28	E1x50	5ht5a_on	0	9.06	No	Yes	Yes	Yes	5	8
289	3x22	E2.Y185	5ht5a_on	0	5.48667	No	No	No	No	4	4
290	3x22	E2.E187	5ht5a_on	0	4.65333	No	No	No	No	4	2
291	3x26	4x61	5ht5a_on	0	4.43667	No	No	No	No	6	6
292	3x34	4x53	5ht5a_on	0	4.00333	No	No	No	No	5	8
293	3x43	7x53	5ht5a_on	0	3.79	No	No	No	Yes	8	9
294	3x44	5x53	5ht5a_on	0	3.17	No	No	No	No	6	6
295	3x46	3x50	5ht5a_on	0	5.42667	No	No	Yes	No	9	9
296	3x46	7x53	5ht5a_on	0	6.04333	No	No	No	Yes	9	9
297	3x47	5x58	5ht5a_on	0	4.44667	No	No	No	No	8	9
298	3x50	7x53	5ht5a_on	0	5.48667	Yes	No	No	Yes	9	9
299	3x51	5x60	5ht5a_on	0	10.7467	Yes	Yes	No	No	8	5
300	4x41	I2x53	5ht5a_on	0	5.05	No	No	No	Yes	6	8
301	I2x54	I2x55	5ht5a_on	0	7.86	No	No	No	No	5	4
302	E2.E191	E2x51	5ht5a_on	0	5.52333	No	Yes	No	No	3	4
303	E2.R196	E2x51	5ht5a_on	0	3.50333	No	No	No	No	4	4
304	5x39	E2.S195	5ht5a_on	0	7.20667	Yes	Yes	No	No	7	3
305	6x55	E2.R196	5ht5a_on	0	6.2	No	No	No	No	7	4
306	5x40	6x59	5ht5a_on	0	3.74	No	No	No	No	6	5
307	5x44	6x55	5ht5a_on	0	4.23333	Yes	No	No	No	6	7
308	5x45	5x48	5ht5a_on	0	3.78667	No	No	No	No	4	5
309	5x47	6x48	5ht5a_on	0	5.34333	No	Yes	Yes	Yes	8	8
310	5x47	6x49	5ht5a_on	0	5.02333	No	Yes	No	Yes	8	6
311	5x49	5x50	5ht5a_on	0	3.83	No	No	No	No	6	9
312	5x58	6x40	5ht5a_on	0	4.3	No	No	No	No	9	8
313	5x62	6x34	5ht5a_on	0	3.55667	No	No	No	No	6	7
314	5x66	6x30	5ht5a_on	0	10.35	No	No	No	No	5	7
315	6x40	7x53	5ht5a_on	0	4.69	No	No	No	Yes	8	9
316	6x43	7x48	5ht5a_on	0	3.49333	No	No	No	No	5	6
317	6x45	6x49	5ht5a_on	0	4.09667	No	No	No	Yes	5	6
318	6x54	E3.I315	5ht5a_on	0	4.05333	No	No	No	No	5	4
319	7x52	7x53	5ht5a_on	0	4.83667	No	No	No	Yes	8	9
320	7x54	8x50	5ht5a_on	0	9.99	No	No	No	Yes	7	0
321	8x47	8x50	5ht5a_on	0	5.04	No	No	No	Yes	0	0
322	8x49	8x50	5ht5a_on	0	3.1	No	No	No	Yes	0	0
323	3x28	Lig	5ht5a_on	0	5.79667	No	Yes	Yes	Yes	5	0
324	7x34	E3.I315	5ht5a_on	0	5.33	No	No	No	No	4	4
325	3x24	E1x52	5ht5a_on	0	3.23	No	No	No	No	5	6
326	6x28	6x31	5ht5a_on	0	2.98667	No	No	No	No	5	5
327	E1x51	E2.E190	5ht5a_on	0	2.97333	No	No	No	No	3	4
328	1x34	1x37	5ht5a_on	0	2.94667	No	No	No	No	4	4
329	5x58	6x37	5ht5a_on	0	2.94667	No	No	No	No	9	8
330	4x39	I2x56	5ht5a_on	0	2.88667	No	No	No	No	3	5
331	E2.E191	E2.S186	5ht5a_on	0	2.87333	No	Yes	No	No	3	2
332	5x55	6x41	5ht5a_on	0	2.85333	No	No	Yes	No	4	8
333	1x36	2x65	5ht5a_on	0	2.77	No	No	No	No	5	5
334	3x28	3x29	5ht5a_on	0	2.74	No	Yes	No	No	5	6
335	6x57	6x61	5ht5a_on	0	2.72667	No	No	No	No	5	3
336	1x50	2x47	5ht5a_on	0	2.60667	No	No	No	No	9	9
337	1x56	I1x50	5ht5a_on	0	2.59	No	No	No	Yes	7	0
338	3x53	3x54	5ht5a_on	0	2.58333	No	No	No	No	8	9
339	1x52	1x56	5ht5a_on	0	2.45333	No	No	No	No	6	7
340	5x47	5x51	5ht5a_on	0	2.44	No	Yes	No	No	8	5
341	5x51	6x44	5ht5a_on	0	2.44	No	No	Yes	No	5	9
342	1x47	1x51	5ht5a_on	0	2.43667	No	Yes	No	No	6	4
343	7x51	7x56	5ht5a_on	0	2.43667	No	No	No	Yes	6	6
344	6x59	E2.R196	5ht5a_on	0	2.4	No	No	No	No	5	4
345	6x49	6x53	5ht5a_on	0	2.37667	No	Yes	No	No	6	5
346	3x23	3x26	5ht5a_on	0	2.33667	No	No	No	No	1	6
347	1x47	2x54	5ht5a_on	0	2.31333	No	Yes	No	No	6	7
348	8x53	I1x50	5ht5a_on	0	2.31	No	No	No	Yes	0	0
349	1x53	2x47	5ht5a_on	0	2.26	No	No	No	No	9	9
350	E1x51	E1x52	5ht5a_on	0	2.21667	No	No	No	No	3	6
351	E1.R105	E1x49	5ht5a_on	0	2.13333	No	Yes	No	No	6	3
352	1x57	I1x50	5ht5a_on	0	2.09667	Yes	No	No	Yes	7	0
353	E2.T184	E2.Y185	5ht5a_on	0	2.08	No	No	No	No	4	4
354	4x56	5x43	5ht5a_on	0	2.06667	No	No	No	No	6	6
355	5x57	5x61	5ht5a_on	0	2.05	No	No	No	No	6	9
356	3x23	3x27	5ht5a_on	0	2.02333	No	No	No	No	1	4
357	5x59	5x60	5ht5a_on	0	1.93333	No	No	No	No	1	5
358	5x39	E2.W181	5ht5a_on	0	1.93	Yes	Yes	No	No	7	7
359	5x69	6x30	5ht5a_on	0	1.9	No	No	No	No	5	7
360	I1x48	I1x51	5ht5a_on	0	1.88	No	No	No	No	0	0
361	8x48	8x51	5ht5a_on	0	1.86667	No	No	No	No	0	0
362	4x40	I2x56	5ht5a_on	0	1.86	No	No	No	No	5	5
363	2x61	2x65	5ht5a_on	0	1.84333	No	No	No	No	6	5
364	2x53	3x35	5ht5a_on	0	1.71	No	No	No	No	7	6
365	7x40	7x41	5ht5a_on	0	1.71	No	No	No	No	8	7
366	2x57	2x58	5ht5a_on	0	1.68	Yes	Yes	No	No	7	9
367	6x29	6x33	5ht5a_on	0	1.60667	No	Yes	No	No	5	8
368	8x49	8x52	5ht5a_on	0	1.49	No	No	No	No	0	0
369	3x56	I2x50	5ht5a_on	0	1.44	No	No	No	No	5	8
370	1x35	1x39	5ht5a_on	0	1.42667	No	No	No	No	4	6
371	1x41	1x45	5ht5a_on	0	1.38667	No	No	No	No	4	4
372	4x58	4x62	5ht5a_on	0	1.38333	No	No	No	No	4	5
373	6x27	6x29	5ht5a_on	0	1.35	No	No	No	Yes	4	5
374	5x42	E2.W181	5ht5a_on	0	1.33667	No	No	No	No	4	7
375	I2x56	I2x57	5ht5a_on	0	1.29333	No	No	No	No	5	7
376	1x56	1x59	5ht5a_on	0	1.29333	No	No	No	No	7	0
377	E2.G182	E2.S195	5ht5a_on	0	1.23667	No	No	No	No	5	3
378	E2.G188	E2.S189	5ht5a_on	0	1.23667	No	No	No	No	4	3
379	5x45	5x46	5ht5a_on	0	1.22667	No	No	No	No	4	5
380	6x26	6x27	5ht5a_on	0	1.16333	No	No	No	No	0	4
381	6x58	E3.C313	5ht5a_on	0	1.14667	No	No	No	No	3	1
382	2x56	3x31	5ht5a_on	0	1.14	No	No	No	No	7	5
383	E2.E183	E2.G182	5ht5a_on	0	1.09	No	No	No	No	4	5
384	1x57	2x44	5ht5a_on	0	1.08	Yes	No	No	No	7	5
385	5x65	6x29	5ht5a_on	0	1.07	No	No	No	Yes	8	5
386	2x67	E1.R105	5ht5a_on	0	1	No	No	No	Yes	4	6
387	3x21	3x22	5ht5a_on	0	1	No	No	No	No	7	4
388	6x45	6x46	5ht5a_on	0	0.993333	No	No	No	No	5	5
389	5x41	6x56	5ht5a_on	0	0.993333	No	No	No	No	6	5
390	5x41	6x60	5ht5a_on	0	0.993333	No	No	No	No	6	5
391	7x36	7x40	5ht5a_on	0	0.95	No	No	No	No	3	8
392	7x31	E1.R105	5ht5a_on	0	0.92	No	No	No	Yes	3	6
393	2x66	E1x49	5ht5a_on	0	0.88	No	No	No	No	3	3
394	6x32	6x36	5ht5a_on	0	0.826667	No	No	No	No	8	8
395	7x56	8x48	5ht5a_on	0	0.826667	No	Yes	No	No	6	0
396	4x62	4x63	5ht5a_on	0	0.813333	No	No	No	No	5	4
397	2x62	2x66	5ht5a_on	0	0.54	No	No	No	No	5	3
398	6x57	6x58	5ht5a_on	0	0.516667	No	No	No	No	5	3
399	7x35	7x36	5ht5a_on	0	0.516667	No	No	No	No	5	3
400	6x31	6x34	5ht5a_on	0	0.506667	No	No	No	No	5	7
401	4x63	4x64	5ht5a_on	0	0.503333	No	No	No	No	4	6
402	1x37	1x38	5ht5a_on	0	0.49	No	No	No	No	4	5
403	5x68	5x69	5ht5a_on	0	0.436667	No	No	No	No	7	5
404	1x58	I1x51	5ht5a_on	0	0.43	No	No	No	No	4	0
405	8x56	8x57	5ht5a_on	0	0.403333	No	No	No	No	0	0

Orange: nodes, hubs and links specific of 5ht5a_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of 5ht5a_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	5ht5a_off Avg Int. Strength	5ht5a_on Avg Int. Strength	5ht5a_off Num Of Links	5ht5a_on Num Of Links	ConSurf
1	1x49	5ht5a_off	6.842	5.79111	5	3	8
2	1x57	5ht5a_off	5.58	1.37556	4	3	7
3	2x46	5ht5a_off	5.33	4.86667	4	3	9
4	2x64	5ht5a_off	8.5125	5.81333	4	1	5
5	3x41	5ht5a_off	9.165	7.42333	4	2	6
6	3x42	5ht5a_off	6.5825	5.50333	4	3	7
7	3x49	5ht5a_off	7.6275	7.71667	4	3	9
8	3x50	5ht5a_off	6.915	5.45667	4	2	9
9	3x52	5ht5a_off	6.575	5.78667	4	3	4
10	4x60	5ht5a_off	5.7875	5.24333	4	3	7
11	5x36	5ht5a_off	4.488	4.54778	5	3	6
12	5x44	5ht5a_off	3.9325	4.81111	4	3	6
13	6x35	5ht5a_off	4.0975	0.886667	4	1	6
14	6x41	5ht5a_off	4.2975	2.60167	4	2	8
15	6x44	5ht5a_off	5.2825	3.36333	4	2	9
16	6x51	5ht5a_off	8.45167	8.075	6	2	7
17	7x38	5ht5a_off	9.03	5.055	4	2	5
18	7x49	5ht5a_off	7.5725	6.55	4	3	9
19	2x42	Shared	4.692	4.33833	5	4	8
20	2x50	Shared	7.1	6.6375	4	4	9
21	2x57	Shared	6.0725	3.46417	4	4	7
22	E1x50	Shared	7.98571	6.42933	7	5	8
23	3x51	Shared	7.1825	5.90733	4	5	8
24	4x38	Shared	8.9975	7.73933	4	5	8
25	4x57	Shared	4.67	2.8725	4	4	8
26	5x39	Shared	6.06	7.715	4	4	7
27	6x48	Shared	7.21857	5.81833	7	6	8
28	6x52	Shared	10.548	7.80333	5	5	6
29	7x39	Shared	6.70571	4.54333	7	4	6
30	7x42	Shared	8.01667	5.76467	6	5	7
31	7x47	Shared	5.1	3.65133	5	5	6
32	Lig	Shared	7.784	7.32833	15	10	0
33	1x47	5ht5a_on	3.35	2.76	2	4	6
34	I1x50	5ht5a_on	0	4.64222	0	6	0
35	2x41	5ht5a_on	6.23	5.065	3	4	4
36	2x63	5ht5a_on	6.25	5.91167	2	4	5
37	E1.R105	5ht5a_on	3.275	1.86	2	4	6
38	3x28	5ht5a_on	14.04	5.625	2	6	5
39	I2x53	5ht5a_on	8.94667	8.80917	3	4	8
40	E2.E191	5ht5a_on	5.42667	3.87667	3	4	3
41	5x47	5ht5a_on	11.6833	6.63467	3	5	8
42	6x29	5ht5a_on	7.43	2.03833	1	4	5
43	6x49	5ht5a_on	1.87	3.72167	1	4	6
44	7x53	5ht5a_on	7.06667	4.93889	3	6	9
45	7x56	5ht5a_on	7.52333	1.82083	3	4	6
46	8x50	5ht5a_on	0	6.65556	0	6	0

Orange: nodes, hubs and links specific of 5ht5a_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of 5ht5a_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	5ht5a_off Recurrence	5ht5a_on Recurrence	5ht5a_off Hub1?	5ht5a_on Hub1?	5ht5a_off Hub2?	5ht5a_on Hub2?	ConSurf1	ConSurf2
1	2x57	7x39	5ht5a_off	13.703	0	Yes	Yes	Yes	Yes	7	6
2	1x46	2x57	5ht5a_off	24.9082	0	No	No	Yes	Yes	7	7
3	1x46	7x47	5ht5a_off	24.2277	7.1887	No	No	Yes	Yes	7	6
4	7x38	7x39	5ht5a_off	17.7242	0	Yes	No	Yes	Yes	5	6
5	6x51	7x38	5ht5a_off	17.8711	0	Yes	No	Yes	No	7	5
6	6x48	6x51	5ht5a_off	46.147	0	Yes	Yes	Yes	No	8	7
7	2x45	4x50	5ht5a_off	19.2669	2.4193	No	No	No	No	9	9
8	2x48	4x50	5ht5a_off	16.6067	0	No	No	No	No	6	9
9	6x40	7x49	5ht5a_off	30.0236	0	No	No	Yes	No	8	9
10	6x40	7x52	5ht5a_off	28.7979	0.0125842	No	No	No	No	8	8
11	6x39	7x52	5ht5a_off	26.3968	0.956396	No	No	No	No	7	8
12	6x35	6x39	5ht5a_off	25.2059	0	Yes	No	No	No	6	7
13	6x35	7x56	5ht5a_off	13.0302	0	Yes	No	No	Yes	6	6
14	2x46	3x46	5ht5a_off	64.9113	0	Yes	No	No	No	9	9
15	2x42	3x46	5ht5a_off	64.1573	0	Yes	Yes	No	No	8	9
16	2x41	4x46	5ht5a_off	17.4264	3.04851	No	Yes	No	No	4	8
17	2x41	4x43	5ht5a_off	12.4812	1.16403	No	Yes	No	No	4	3
18	2x48	2x52	5ht5a_off	11.1936	0	No	No	No	No	6	6
19	2x64	3x28	5ht5a_off	31.1101	0	Yes	No	No	Yes	5	5
20	2x59	3x28	5ht5a_off	29.1961	1.06022	No	No	No	Yes	5	5
21	2x59	E1x50	5ht5a_off	26.9729	0	No	No	Yes	Yes	5	8
22	5x39	Lig	5ht5a_off	39.7402	0	Yes	Yes	Yes	Yes	7	0
23	4x60	E2.T184	5ht5a_off	14.2134	0	Yes	No	No	No	7	4
24	3x26	E2.T184	5ht5a_off	11.8084	0	No	No	No	No	6	4
25	3x40	6x48	5ht5a_off	24.3166	6.00579	No	No	Yes	Yes	8	8
26	3x40	5x50	5ht5a_off	23.3809	4.81659	No	No	No	No	8	9
27	3x44	5x50	5ht5a_off	13.1849	0	No	No	No	No	6	9
28	2x42	4x45	5ht5a_off	22.5419	0	Yes	Yes	No	No	8	5
29	3x48	4x45	5ht5a_off	20.3379	2.36582	No	No	No	No	6	5
30	3x48	3x52	5ht5a_off	18.4472	7.08488	No	No	Yes	No	6	4
31	3x53	4x38	5ht5a_off	17.3027	3.31907	No	No	Yes	Yes	8	8
32	3x50	3x53	5ht5a_off	15.238	0	Yes	No	No	No	9	8
33	3x51	3x55	5ht5a_off	19.5144	5.99006	Yes	Yes	No	No	8	6
34	4x39	4x43	5ht5a_off	10.0027	0	No	No	No	No	3	3
35	5x36	5x39	5ht5a_off	14.5188	0	Yes	No	Yes	Yes	6	7
36	7x47	7x48	5ht5a_off	26.9265	3.62109	Yes	Yes	No	No	6	6
37	7x43	7x48	5ht5a_off	25.5693	1.21123	No	No	No	No	4	6
38	7x40	7x43	5ht5a_off	24.2045	0	No	No	No	No	8	4
39	6x50	7x40	5ht5a_off	22.8318	0	No	No	No	No	9	8
40	6x50	7x37	5ht5a_off	20.0634	5.86422	No	No	No	No	9	5
41	6x54	7x37	5ht5a_off	18.6637	5.01793	No	No	No	No	5	5
42	6x54	6x57	5ht5a_off	17.2602	0	No	No	No	No	5	5
43	6x57	E3.S312	5ht5a_off	14.4299	0	No	No	No	No	5	1
44	E3.I315	E3.S312	5ht5a_off	13.0031	0	No	No	No	No	4	1
45	3x44	5x54	5ht5a_off	11.936	1.20808	No	No	No	No	6	8
46	5x54	6x41	5ht5a_off	10.4706	0	No	No	Yes	No	8	8
47	6x51	Lig	5ht5a_off	28.5736	0.229661	Yes	No	Yes	Yes	7	0
48	2x64	Lig	5ht5a_off	31.7287	0	Yes	No	Yes	Yes	5	0
49	1x49	7x47	Shared	15.3346	15.2929	Yes	No	Yes	Yes	8	6
50	1x49	7x50	Shared	14.6425	37.5102	Yes	No	No	No	8	9
51	1x50	7x50	Shared	15.1065	38.5044	No	No	No	No	9	9
52	1x50	2x50	Shared	16.4443	43.3807	No	No	Yes	Yes	9	9
53	6x48	7x45	Shared	100	100	Yes	Yes	No	No	8	9
54	7x45	7x49	Shared	99.4896	99.1631	No	No	Yes	No	9	9
55	2x46	7x49	Shared	93.9566	73.7683	Yes	No	Yes	No	9	9
56	2x46	3x42	Shared	29.0686	66.7118	Yes	No	Yes	No	9	7
57	2x45	3x42	Shared	26.0411	65.1325	No	No	Yes	No	9	7
58	6x36	7x56	Shared	10.4628	17.4133	No	No	No	Yes	8	6
59	2x45	4x46	Shared	13.4555	62.7163	No	No	No	No	9	8
60	2x42	4x46	Shared	14.8475	58.8404	Yes	Yes	No	No	8	8
61	7x38	Lig	Shared	12.0288	19.1845	Yes	No	Yes	Yes	5	0
62	4x60	5x39	Shared	23.7405	13.1221	Yes	No	Yes	Yes	7	7
63	3x33	Lig	Shared	16.9122	11.3666	No	No	Yes	Yes	7	0
64	3x33	4x57	Shared	14.5188	10.2058	No	No	Yes	Yes	7	8
65	3x36	Lig	Shared	28.8288	44.1263	No	No	Yes	Yes	6	0
66	2x42	3x49	Shared	28.419	57.4372	Yes	Yes	Yes	No	8	9
67	3x49	I2x53	Shared	18.8803	20.5059	Yes	No	No	Yes	9	8
68	3x52	I2x53	Shared	19.8701	20.8173	Yes	No	No	Yes	4	8
69	3x51	3x52	Shared	26.505	13.0403	Yes	Yes	Yes	No	8	4
70	6x52	Lig	Shared	30.1589	52.1771	Yes	Yes	Yes	Yes	6	0
71	2x50	7x49	Shared	22.8744	47.1686	Yes	Yes	Yes	No	9	9
72	2x57	7x42	Shared	19.9551	17.0421	Yes	Yes	Yes	Yes	7	7
73	7x38	7x42	Shared	11.7426	18.269	Yes	No	Yes	Yes	5	7
74	3x36	6x48	Shared	28.7747	44.3466	No	No	Yes	Yes	6	8
75	6x48	6x52	Shared	32.9853	51.7366	Yes	Yes	Yes	Yes	8	6
76	7x39	7x42	5ht5a_on	0.305456	17.7971	Yes	Yes	Yes	Yes	6	7
77	3x32	7x42	5ht5a_on	5.47887	18.3508	No	No	Yes	Yes	8	7
78	3x32	Lig	5ht5a_on	9.19847	22.9881	No	No	Yes	Yes	8	0
79	1x49	7x51	5ht5a_on	1.41902	22.9315	Yes	No	No	No	8	6
80	3x49	4x38	5ht5a_on	8.72289	36.321	Yes	No	Yes	Yes	9	8
81	2x39	4x38	5ht5a_on	8.60689	27.0339	No	No	Yes	Yes	8	8
82	2x39	2x40	5ht5a_on	0	26.5526	No	No	No	No	8	9
83	2x40	8x50	5ht5a_on	0	24.407	No	No	No	Yes	9	0
84	8x50	I1x50	5ht5a_on	0	17.9607	No	Yes	No	Yes	0	0
85	2x46	7x53	5ht5a_on	0	10.3977	Yes	No	No	Yes	9	9
86	3x28	Lig	5ht5a_on	0	25.7535	No	Yes	Yes	Yes	5	0
87	2x63	3x28	5ht5a_on	0	12.0588	No	Yes	No	Yes	5	5
88	5x43	Lig	5ht5a_on	2.13819	25.5962	No	No	Yes	Yes	6	0
89	5x39	5x43	5ht5a_on	0.0618644	23.3971	Yes	Yes	No	No	7	6
90	4x60	4x61	5ht5a_on	2.43591	10.6242	Yes	No	No	No	7	6
91	6x55	Lig	5ht5a_on	0.761706	12.3105	No	No	Yes	Yes	7	0
92	6x55	E2.R196	5ht5a_on	0	13.2668	No	No	No	No	7	4
93	6x59	E2.R196	5ht5a_on	0	10.7186	No	No	No	No	5	4
94	7x51	7x56	5ht5a_on	0	21.8429	No	No	No	Yes	6	6
95	6x32	6x36	5ht5a_on	0	16.545	No	No	No	No	8	8
96	6x29	6x32	5ht5a_on	1.35328	15.4187	No	Yes	No	No	5	8
97	6x27	6x29	5ht5a_on	0	12.2444	No	No	No	Yes	4	5
98	6x27	6x30	5ht5a_on	1.35328	10.1837	No	No	No	No	4	7

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
2x56	3x32	Shared	10.22	6.81333	1	1	2	1
2x56	7x42	Shared	5.05	4.21	1	1	2	2
2x59	E1x50	5ht5a_off	5.69	0	0	0	2	2
2x59	3x28	Shared	19.36	7.21333	0	0	2	1
2x60	2x64	5ht5a_off	10.06	0	1	0	2	1
2x60	7x39	5ht5a_off	7.41	0	1	0	2	2
2x60	7x42	5ht5a_off	5.09	0	1	0	2	2
2x63	E1x50	Shared	6.35	8.46333	0	1	2	2
2x64	3x28	5ht5a_off	8.72	0	0	0	1	1
2x64	E2x51	5ht5a_off	6.37	0	0	0	1	2
2x64	Lig	5ht5a_off	8.9	0	0	0	1	0
3x29	E2x52	Shared	4.61	3.07333	0	0	2	1
3x32	7x42	Shared	8.05	9.19667	1	1	1	2
3x32	Lig	Shared	14.59	15.9067	1	1	1	0
3x33	4x57	Shared	6.46	4.84667	0	0	1	2
3x33	Lig	Shared	4	8.47	0	0	1	0
3x36	6x48	Shared	5.22	3.48	0	0	1	2
3x36	Lig	Shared	4.27	6.30667	0	0	1	0
3x37	4x53	Shared	6.4	5.86333	1	0	1	2
3x37	5x461	Shared	5.03	3.36	1	0	1	1
3x37	Lig	Shared	3.96	4.35333	1	0	1	0
4x60	5x39	Shared	12.52	11.1267	0	0	2	1
5x36	E2.W181	5ht5a_off	6.54	0	1	0	2	2
E2x52	Lig	5ht5a_off	11.01	0	0	0	1	0
5x39	5x43	Shared	5.09	10.5967	1	0	1	1
5x39	Lig	5ht5a_off	5.51	0	1	0	1	0
5x43	Lig	Shared	15.13	6.19333	1	0	1	0
5x44	5x48	Shared	4.99	4.57667	1	0	1	2
5x44	6x52	Shared	5.19	5.62333	1	0	1	1
5x44	Lig	5ht5a_off	3.96	0	1	0	1	0
5x461	Lig	5ht5a_off	4.24	0	1	0	1	0
5x47	5x48	5ht5a_off	8.25	0	0	1	2	2
5x47	6x52	Shared	22.51	16.08	0	1	2	1
6x48	6x51	5ht5a_off	7.02	0	1	1	2	1
6x48	6x52	Shared	8.02	5.34333	1	1	2	1
6x51	6x52	Shared	9.65	6.07667	1	1	1	1
6x51	6x55	5ht5a_off	13.99	0	1	1	1	1
6x51	7x34	5ht5a_off	4.96	0	1	1	1	2
6x51	7x38	5ht5a_off	6.09	0	1	1	1	1
6x51	Lig	Shared	9	10.0733	1	1	1	0
6x52	Lig	Shared	7.37	5.89333	1	1	1	0
6x55	7x34	5ht5a_off	5.4	0	1	0	1	2
6x55	Lig	Shared	12.47	4.86667	1	0	1	0
7x38	7x39	5ht5a_off	4.56	0	1	0	1	2
7x38	7x42	Shared	15.24	4.68667	1	0	1	2
7x38	Lig	Shared	10.23	5.42333	1	0	1	0
7x39	7x42	Shared	8.68	5.14333	1	0	2	2
5x40	Lig	5ht5a_off	2.12	0	0	0	1	0
5x44	5x45	5ht5a_off	1.59	0	1	0	1	2
5x36	E2.S195	Shared	1.44	6.71	1	0	2	2
5x36	5x39	5ht5a_off	1.12	0	1	0	2	1
2x60	3x28	5ht5a_on	0	3.29667	1	0	2	1
2x63	3x28	5ht5a_on	0	5.64333	0	1	2	1
2x64	7x39	5ht5a_on	0	5.81333	0	0	1	2
3x28	E1x50	5ht5a_on	0	9.06	0	1	1	2
E2.R196	E2x51	5ht5a_on	0	3.50333	0	0	2	2
5x39	E2.S195	5ht5a_on	0	7.20667	1	0	1	2
6x55	E2.R196	5ht5a_on	0	6.2	1	0	1	2
5x40	6x59	5ht5a_on	0	3.74	0	0	1	2
5x44	6x55	5ht5a_on	0	4.23333	1	0	1	1
5x45	5x48	5ht5a_on	0	3.78667	0	0	2	2
5x47	6x48	5ht5a_on	0	5.34333	0	1	2	2
3x28	Lig	5ht5a_on	0	5.79667	0	1	1	0
3x28	3x29	5ht5a_on	0	2.74	0	1	1	2
6x59	E2.R196	5ht5a_on	0	2.4	0	0	2	2
4x56	5x43	5ht5a_on	0	2.06667	0	0	2	1
5x39	E2.W181	5ht5a_on	0	1.93	1	0	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	5ht5a_off	7UM4-5-HT_5A-AS2674723
	5ht5a_on	7UM5-5-HT_5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT_5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT_5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2

Network Difference
Value	5ht5a_off	5ht5a_on
I_min	3.95	3.03333
Number of Linked Nodes	233	259
Number of Specific Nodes	9 (3.86%)	35 (13.51%)
Number of Shared Nodes	224 (96.14%)	224 (86.49%)
Number of Links	264	274
Number of Specific Links	131 (49.62%)	141 (51.46%)
Number of Shared Links	133 (50.38%)	133 (48.54%)
Number of Hubs	32	28
Number of Specific Hubs	18 (56.25%)	14 (50.00%)
Number of Shared Hubs	14 (43.75%)	14 (50.00%)
Average % Shared Neighbours (Jaccard)	33.08
Average % Shared Neighbours (Otsuka)	41.46
Average % Shared Neighbours (Overlap Coefficient)	50.67
Average % Shared Cliques (k3-6)	78.33
Graphlets Similarity	0.498817

Paths Difference
Value	5ht5a_off	5ht5a_on
Number Of Nodes in MetaPath	70	49
Specific Nodes in MetaPath	38 (54.29%)	17 (34.69%)
Shared Nodes in MetaPath	224 (96.14%)	224 (96.14%)
Number Of Links MetaPath	75	50
Specific Links in MetaPath	48 (64.00%)	23 (46.00%)
Shared Links in MetaPath	133 (50.38%)	133 (50.38%)
Number of Shortest Paths	51761	50534
Length Of Smallest Path	3	3
Average Path Length	13.3143	14.4532
Length of Longest Path	30	32
Minimum Path Strength	1.22	0.658333
Average Path Strength	6.76937	5.50695
Maximum Path Strength	16.08	12.6267
Minimum Path Correlation	0.7	0.7
Average Path Correlation	0.910741	0.92078
Maximum Path Correlation	0.99	0.99
Minimum % Of Corr. Nodes	4	3.7037
Average % Of Corr. Nodes	42.6198	43.1077
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	45.2648	34.4911
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

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