psnGPCR

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Orange: nodes, hubs and links specific of 5ht_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of 5ht_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	5ht_off Int. Strength	5ht_on Int. Strength	5ht_off Hub1?	5ht_on Hub1?	5ht_off Hub2?	5ht_on Hub2?	ConSurf1	ConSurf2
1	1x46	2x54	5ht_off	100	0	No	No	No	No	7	6
2	1x46	2x57	5ht_off	100	0	No	No	Yes	Yes	7	8
3	1x49	7x50	5ht_off	100	0	No	No	No	No	8	9
4	1x50	2x47	5ht_off	100	0	No	Yes	No	No	9	9
5	1x56	8x50	5ht_off	100	0	No	No	Yes	Yes	7	8
6	1x59	8x57	5ht_off	100	0	No	No	Yes	No	5	4
7	2x53	2x56	5ht_off	100	0	No	No	Yes	No	7	8
8	2x60	3x28	5ht_off	100	0	No	No	Yes	No	7	5
9	2x60	7x42	5ht_off	100	0	No	No	Yes	Yes	7	7
10	2x61	7x39	5ht_off	100	0	No	No	Yes	Yes	6	6
11	2x66	E1x51	5ht_off	100	0	No	No	No	No	4	3
12	7x35	E1	5ht_off	100	0	No	No	No	No	4	3
13	3x25	E2	5ht_off	100	0	No	No	Yes	Yes	9	3
14	3x28	3x29	5ht_off	100	0	Yes	No	No	No	5	5
15	3x30	4x57	5ht_off	100	0	No	No	No	No	6	7
16	3x37	Lig	5ht_off	100	0	No	No	Yes	Yes	7	0
17	3x38	4x53	5ht_off	100	0	No	No	No	No	8	8
18	3x40	5x50	5ht_off	100	0	No	No	No	No	8	9
19	3x41	3x44	5ht_off	100	0	No	No	No	No	6	6
20	3x42	4x46	5ht_off	100	0	Yes	Yes	No	No	8	8
21	3x43	6x44	5ht_off	100	0	No	No	Yes	Yes	8	9
22	3x49	4x45	5ht_off	100	0	Yes	Yes	No	No	9	6
23	3x54	5x64	5ht_off	100	0	No	No	Yes	No	9	6
24	3x54	5x68	5ht_off	100	0	No	No	No	No	9	7
25	4x41	4x45	5ht_off	100	0	No	No	No	No	6	6
26	4x52	4x56	5ht_off	100	0	No	No	No	No	5	6
27	4x68	E2	5ht_off	100	0	No	No	Yes	Yes	4	3
28	5x36	5x39	5ht_off	100	0	Yes	No	No	No	5	7
29	5x44	Lig	5ht_off	100	0	No	No	Yes	Yes	6	0
30	5x51	6x45	5ht_off	100	0	No	No	No	No	6	6
31	5x53	5x57	5ht_off	100	0	No	No	No	No	6	5
32	5x54	6x41	5ht_off	100	0	No	No	Yes	No	8	8
33	5x58	5x62	5ht_off	100	0	Yes	Yes	No	No	9	5
34	6x44	7x45	5ht_off	100	0	Yes	Yes	No	No	9	9
35	6x48	6x51	5ht_off	100	0	Yes	Yes	Yes	No	8	7
36	6x48	Lig	5ht_off	100	0	Yes	Yes	Yes	Yes	8	0
37	6x51	6x52	5ht_off	100	0	Yes	No	Yes	Yes	7	7
38	6x51	7x34	5ht_off	100	0	Yes	No	No	No	7	3
39	6x54	7x30	5ht_off	100	0	No	No	No	No	5	4
40	6x58	7x30	5ht_off	100	0	No	No	No	No	4	4
41	7x33	7x37	5ht_off	100	0	No	No	Yes	No	4	5
42	7x38	Lig	5ht_off	100	0	No	No	Yes	Yes	6	0
43	7x42	Lig	5ht_off	100	0	Yes	Yes	Yes	Yes	7	0
44	7x53	8x50	5ht_off	100	0	No	Yes	Yes	Yes	9	8
45	7x54	8x54	5ht_off	100	0	No	No	No	No	7	6
46	8x48	8x52	5ht_off	100	0	No	No	No	No	5	4
47	3x40	Lig	5ht_off	100	0	No	No	Yes	Yes	8	0
48	1x47	2x54	5ht_off	100	0	No	No	No	No	5	6
49	3x43	6x41	5ht_off	100	0	No	No	Yes	No	8	8
50	5x66	6x31	5ht_off	100	0	No	No	Yes	No	6	5
51	6x26	6x29	5ht_off	100	0	No	No	No	No	5	6
52	6x37	6x41	5ht_off	100	0	No	No	Yes	No	8	8
53	3x49	3x50	5ht_off	100	0	Yes	Yes	Yes	No	9	9
54	NT	NT	5ht_off	100	0	Yes	No	Yes	No	0	0
55	1x33	NT	5ht_off	100	0	No	No	Yes	No	5	0
56	2x38	4x39	5ht_off	100	0	No	No	No	No	5	4
57	5x48	6x52	5ht_off	100	0	Yes	Yes	Yes	Yes	5	7
58	2x67	NT	5ht_off	100	0	No	No	Yes	No	5	0
59	5x62	6x31	5ht_off	100	0	No	No	Yes	No	5	5
60	5x64	5x68	5ht_off	100	0	Yes	No	No	No	6	7
61	7x35	NT	5ht_off	100	0	No	No	Yes	No	4	0
62	1x32	NT	5ht_off	100	0	No	No	Yes	No	6	0
63	1x52	1x56	5ht_off	100	0	No	No	No	No	6	7
64	I2x53	I2x56	5ht_off	100	0	Yes	Yes	No	No	7	4
65	4x63	5x36	5ht_off	100	0	No	No	Yes	No	5	5
66	6x61	7x30	5ht_off	100	0	No	No	No	No	3	4
67	7x33	7x36	5ht_off	100	0	No	No	No	No	4	4
68	8x55	CT	5ht_off	100	0	No	No	Yes	No	3	3
69	2x39	3x50	5ht_off	66.6667	0	No	No	Yes	No	8	9
70	2x52	2x551	5ht_off	50	0	No	No	No	No	7	5
71	6x51	6x55	5ht_off	50	0	Yes	No	No	No	7	7
72	1x42	7x43	5ht_off	50	0	No	No	No	No	7	4
73	7x37	7x40	5ht_off	56.6667	0	Yes	No	No	No	5	7
74	2x62	E1x52	5ht_off	66.6667	0	No	No	Yes	No	4	5
75	5x66	5x69	5ht_off	50	0	No	No	No	No	6	5
76	2x51	2x55	5ht_off	26.6667	0	No	No	No	No	7	4
77	2x64	E1	5ht_off	50	0	No	No	No	No	5	3
78	3x34	3x35	5ht_off	50	0	No	No	No	No	6	7
79	6x40	7x49	5ht_off	50	0	No	No	No	Yes	8	9
80	5x55	6x41	5ht_off	50	0	No	No	Yes	No	5	8
81	1x52	8x57	5ht_off	33.3333	0	No	No	Yes	No	6	4
82	2x41	4x43	5ht_off	50	0	No	No	No	No	4	4
83	4x59	5x39	5ht_off	50	0	No	No	No	No	4	7
84	E1x50	E1x51	5ht_off	50	0	Yes	Yes	No	No	7	3
85	7x32	NT	5ht_off	50	0	No	No	Yes	No	1	0
86	2x37	2x39	5ht_off	50	0	No	No	No	No	7	8
87	1x57	2x40	5ht_off	0	0	No	No	No	No	7	9
88	3x55	3x56	5ht_off	16.6667	0	No	No	Yes	No	6	6
89	1x54	2x47	5ht_off	50	0	No	No	No	No	6	9
90	1x56	8x53	5ht_off	50	0	No	No	No	No	7	7
91	1x32	2x65	5ht_off	53.3333	0	No	No	No	Yes	6	5
92	5x68	6x30	5ht_off	50	0	No	No	No	No	7	8
93	1x34	1x35	5ht_off	50	0	No	No	No	No	4	3
94	5x61	6x34	5ht_off	0	0	No	No	No	No	9	7
95	1x42	2x57	5ht_off	0	0	No	No	Yes	Yes	7	8
96	7x48	7x51	5ht_off	50	0	No	No	No	No	6	6
97	I2x55	I2x56	5ht_off	50	0	No	No	No	No	4	4
98	4x61	5x39	5ht_off	50	0	No	No	No	No	6	7
99	5x64	5x67	5ht_off	50	0	Yes	No	No	No	6	5
100	4x54	4x58	5ht_off	50	0	No	No	No	No	4	0
101	5x65	6x31	5ht_off	16.6667	0	No	No	Yes	No	8	5
102	3x21	E1x52	5ht_off	50	0	No	No	Yes	No	7	5
103	5x69	6x27	5ht_off	16.6667	0	No	No	No	No	5	5
104	5x45	5x46	5ht_off	50	0	No	No	No	No	4	4
105	7x51	7x55	5ht_off	50	0	No	No	No	No	6	5
106	6x31	6x32	5ht_off	50	0	Yes	No	No	No	5	8
107	8x57	CT	5ht_off	50	0	Yes	No	Yes	No	4	3
108	7x52	7x56	5ht_off	0	0	No	No	No	No	8	7
109	6x58	6x59	5ht_off	50	0	No	No	No	No	4	5
110	1x31	1x34	5ht_off	50	0	No	No	No	No	3	4
111	8x58	CT	5ht_off	0	0	No	No	Yes	No	6	3
112	3x26	4x66	5ht_off	16.6667	0	No	No	No	No	6	5
113	3x50	3x53	5ht_off	3.33333	0	Yes	No	No	No	9	8
114	8x59	CT	5ht_off	16.6667	0	No	No	Yes	No	4	3
115	3x50	6x33	5ht_off	20	0	Yes	No	No	No	9	8
116	3x56	I2x51	5ht_off	33.3333	0	Yes	No	No	No	6	7
117	4x41	4x44	5ht_off	23.3333	0	No	No	No	No	6	3
118	7x29	7x33	5ht_off	16.6667	0	No	No	No	No	5	4
119	6x28	6x32	5ht_off	0	0	No	No	No	No	6	8
120	3x23	3x24	5ht_off	16.6667	0	No	No	No	Yes	1	5
121	4x56	5x42	5ht_off	0	0	No	No	No	No	6	4
122	1x35	1x38	5ht_off	0	0	No	No	No	No	3	4
123	1x58	2x44	5ht_off	3.33333	0	No	No	No	No	1	5
124	1x28	1x30	5ht_off	0	0	No	No	No	No	3	1
125	6x56	6x60	5ht_off	0	0	No	No	No	No	5	4
126	1x34	1x37	5ht_off	0	0	No	No	No	No	4	4
127	2x67	E1x49	5ht_off	0	0	No	No	No	No	5	4
128	4x55	4x58	5ht_off	0	0	No	No	No	No	4	0
129	5x52	5x55	5ht_off	0	0	No	No	No	No	3	5
130	4x47	4x51	5ht_off	0	0	No	No	No	No	2	4
131	1x27	1x30	5ht_off	6.66667	0	No	No	No	No	2	1
132	I2x54	I2x56	5ht_off	6.66667	0	No	No	No	No	6	4
133	1x411	1x42	5ht_off	0	0	No	No	No	No	0	7
134	4x51	4x52	5ht_off	0	0	No	No	No	No	4	5
135	4x63	4x67	5ht_off	0	0	No	No	No	No	5	6
136	1x39	2x61	Shared	100	100	No	No	No	No	6	6
137	1x39	7x39	Shared	100	100	No	No	Yes	Yes	6	6
138	1x43	2x57	Shared	100	100	No	No	Yes	Yes	6	8
139	1x46	7x47	Shared	100	100	No	No	No	No	7	6
140	1x47	2x55	Shared	100	21.7593	No	No	No	No	5	4
141	1x50	2x50	Shared	100	100	No	Yes	Yes	Yes	9	9
142	1x50	7x50	Shared	100	100	No	Yes	No	No	9	9
143	1x52	8x54	Shared	100	50	No	No	No	No	6	6
144	1x53	2x47	Shared	100	100	No	No	No	No	9	9
145	1x54	2x48	Shared	100	22.2222	No	No	No	No	6	6
146	1x57	2x44	Shared	100	100	No	No	No	No	7	5
147	1x60	I1x50	Shared	100	100	No	Yes	Yes	Yes	6	8
148	I1x48	I1x51	Shared	100	42.1296	No	No	No	No	6	7
149	2x40	I1x50	Shared	100	100	No	No	Yes	Yes	9	8
150	8x49	I1x50	Shared	100	100	No	No	Yes	Yes	6	8
151	8x50	I1x50	Shared	100	100	Yes	Yes	Yes	Yes	8	8
152	2x41	I1x51	Shared	100	16.6667	No	No	No	No	4	7
153	2x37	2x40	Shared	100	100	No	No	No	No	7	9
154	2x41	4x39	Shared	100	100	No	No	No	No	4	4
155	2x42	3x46	Shared	100	100	Yes	Yes	No	No	8	9
156	2x42	4x46	Shared	100	100	Yes	Yes	No	No	8	8
157	2x43	7x53	Shared	100	30.5556	No	No	No	Yes	8	9
158	2x45	3x42	Shared	100	100	No	No	Yes	Yes	9	8
159	2x45	4x46	Shared	100	100	No	No	No	No	9	8
160	2x46	2x50	Shared	100	100	No	Yes	Yes	Yes	9	9
161	2x49	4x50	Shared	100	50	No	No	No	Yes	8	9
162	2x50	3x39	Shared	100	100	Yes	Yes	No	No	9	9
163	2x50	7x46	Shared	100	100	Yes	Yes	No	No	9	9
164	2x50	7x49	Shared	100	100	Yes	Yes	No	Yes	9	9
165	2x52	3x35	Shared	100	100	No	No	No	No	7	7
166	2x53	7x46	Shared	100	100	No	No	No	No	7	9
167	2x56	3x28	Shared	100	50	Yes	No	Yes	No	8	5
168	2x56	3x32	Shared	100	100	Yes	No	Yes	Yes	8	8
169	2x56	7x42	Shared	100	100	Yes	No	Yes	Yes	8	7
170	2x57	7x39	Shared	100	100	Yes	Yes	Yes	Yes	8	6
171	2x57	7x42	Shared	100	100	Yes	Yes	Yes	Yes	8	7
172	2x59	3x28	Shared	100	100	No	No	Yes	No	4	5
173	2x60	7x39	Shared	100	66.6667	No	No	Yes	Yes	7	6
174	2x63	E1x50	Shared	100	100	No	No	Yes	Yes	5	7
175	2x64	7x39	Shared	100	58.3333	No	No	Yes	Yes	5	6
176	E1x50	E1x52	Shared	100	100	Yes	Yes	Yes	No	7	5
177	3x25	E1x50	Shared	100	100	No	No	Yes	Yes	9	7
178	3x28	E1x50	Shared	100	100	Yes	No	Yes	Yes	5	7
179	E1x50	E2x50	Shared	100	100	Yes	Yes	No	No	7	9
180	3x24	E1x52	Shared	100	100	No	Yes	Yes	No	5	5
181	3x22	E2	Shared	100	100	No	No	Yes	Yes	3	3
182	3x25	E2x50	Shared	100	100	No	No	No	No	9	9
183	3x30	4x62	Shared	100	16.6667	No	No	No	No	6	5
184	3x32	3x36	Shared	100	100	Yes	Yes	No	No	8	7
185	3x32	7x42	Shared	100	100	Yes	Yes	Yes	Yes	8	7
186	3x32	Lig	Shared	100	100	Yes	Yes	Yes	Yes	8	0
187	3x33	4x57	Shared	100	100	No	No	No	No	6	7
188	3x33	Lig	Shared	100	100	No	No	Yes	Yes	6	0
189	3x34	4x57	Shared	100	100	No	No	No	No	6	7
190	3x36	Lig	Shared	100	100	No	No	Yes	Yes	7	0
191	3x37	4x53	Shared	100	100	No	No	No	No	7	8
192	3x37	5x461	Shared	100	100	No	No	No	No	7	6
193	3x38	4x50	Shared	100	100	No	No	No	Yes	8	9
194	3x40	6x44	Shared	100	100	No	No	Yes	Yes	8	9
195	3x41	5x50	Shared	100	100	No	No	No	No	6	9
196	3x42	4x49	Shared	100	100	Yes	Yes	No	No	8	6
197	3x42	4x50	Shared	100	100	Yes	Yes	No	Yes	8	9
198	3x44	5x53	Shared	100	72.2222	No	No	No	No	6	6
199	3x44	5x54	Shared	100	59.2593	No	No	No	No	6	8
200	3x47	5x57	Shared	100	39.3519	No	No	No	No	9	5
201	3x51	3x55	Shared	100	100	Yes	Yes	No	No	8	6
202	3x51	5x60	Shared	100	100	Yes	Yes	No	No	8	5
203	3x51	5x61	Shared	100	50	Yes	Yes	No	No	8	9
204	3x55	5x64	Shared	100	16.6667	No	No	Yes	No	6	6
205	3x56	I2x52	Shared	100	33.3333	Yes	No	No	No	6	5
206	4x59	4x60	Shared	100	100	No	No	No	No	4	7
207	E2	E2	Shared	100	100	Yes	Yes	Yes	Yes	3	3
208	5x36	E2	Shared	100	100	Yes	No	Yes	Yes	5	3
209	E2	E2x51	Shared	100	100	Yes	Yes	No	No	3	4
210	5x44	5x48	Shared	100	100	No	No	Yes	Yes	6	5
211	5x44	6x52	Shared	100	100	No	No	Yes	Yes	6	7
212	5x45	5x48	Shared	100	100	No	No	Yes	Yes	4	5
213	5x47	5x48	Shared	100	100	No	Yes	Yes	Yes	8	5
214	5x47	6x52	Shared	100	100	No	Yes	Yes	Yes	8	7
215	5x48	6x56	Shared	100	100	Yes	Yes	No	No	5	5
216	5x49	5x50	Shared	100	100	No	No	No	No	5	9
217	5x58	6x38	Shared	100	16.6667	Yes	Yes	No	No	9	6
218	6x25	6x29	Shared	100	16.6667	No	No	No	No	5	6
219	6x36	7x56	Shared	100	100	No	No	No	No	8	7
220	6x40	7x52	Shared	100	100	No	No	No	No	8	8
221	6x44	6x48	Shared	100	100	Yes	Yes	Yes	Yes	9	8
222	6x47	7x45	Shared	100	100	No	No	No	No	8	9
223	6x48	6x52	Shared	100	100	Yes	Yes	Yes	Yes	8	7
224	6x48	7x41	Shared	100	100	Yes	Yes	No	No	8	7
225	6x50	7x37	Shared	100	100	No	No	Yes	No	9	5
226	6x51	7x38	Shared	100	100	Yes	No	No	No	7	6
227	6x51	Lig	Shared	100	100	Yes	No	Yes	Yes	7	0
228	6x52	Lig	Shared	100	100	Yes	Yes	Yes	Yes	7	0
229	6x54	7x34	Shared	100	100	No	No	No	No	5	3
230	6x54	7x37	Shared	100	100	No	No	Yes	No	5	5
231	6x61	E3	Shared	100	100	No	No	No	Yes	3	3
232	7x36	7x37	Shared	100	25	No	No	Yes	No	4	5
233	7x38	7x42	Shared	100	100	No	No	Yes	Yes	6	7
234	7x39	7x42	Shared	100	100	Yes	Yes	Yes	Yes	6	7
235	8x47	8x49	Shared	100	100	No	No	No	No	9	6
236	8x47	8x50	Shared	100	100	No	No	Yes	Yes	9	8
237	8x48	8x51	Shared	100	33.3333	No	No	No	No	5	9
238	1x60	I1x49	Shared	100	39.3519	No	Yes	No	No	6	6
239	2x46	3x42	Shared	100	100	No	Yes	Yes	Yes	9	8
240	3x41	4x52	Shared	100	100	No	No	No	No	6	5
241	3x48	3x52	Shared	100	41.6667	No	No	No	Yes	6	5
242	5x47	5x51	Shared	100	100	No	Yes	No	No	8	6
243	5x58	6x41	Shared	100	100	Yes	Yes	Yes	No	9	8
244	6x49	6x53	Shared	100	44.4444	No	No	No	No	6	6
245	5x58	5x59	Shared	100	16.6667	Yes	Yes	No	No	9	1
246	7x43	7x48	Shared	100	47.2222	No	No	No	No	4	6
247	7x45	7x49	Shared	100	100	No	No	No	Yes	9	9
248	I2x53	I2x57	Shared	100	100	Yes	Yes	No	No	7	6
249	6x58	7x34	Shared	100	100	No	No	No	No	4	3
250	3x26	4x61	Shared	100	38.8889	No	No	No	No	6	6
251	3x45	4x45	Shared	100	50	No	No	No	No	7	6
252	3x49	I2x53	Shared	100	100	Yes	Yes	Yes	Yes	9	7
253	3x49	I2x57	Shared	100	100	Yes	Yes	No	No	9	6
254	3x52	I2x53	Shared	100	100	No	Yes	Yes	Yes	5	7
255	4x63	E2	Shared	100	100	No	No	Yes	Yes	5	3
256	1x36	2x65	Shared	66.6667	48.6111	No	No	No	Yes	6	5
257	2x551	3x31	Shared	53.3333	25	No	No	No	No	5	5
258	2x42	3x45	Shared	23.3333	20.8333	Yes	Yes	No	No	8	7
259	7x26	7x29	Shared	50	16.6667	No	No	No	No	1	5
260	E2x52	Lig	Shared	70	100	No	No	Yes	Yes	4	0
261	3x51	5x57	Shared	66.6667	100	Yes	Yes	No	No	8	5
262	6x45	6x49	Shared	50	66.6667	No	No	No	No	6	6
263	1x55	8x57	Shared	50	22.2222	No	No	Yes	No	4	4
264	2x38	I2x57	Shared	66.6667	50	No	No	No	No	5	6
265	3x34	4x54	Shared	16.6667	25	No	No	No	No	6	4
266	4x64	E2	Shared	50	33.7963	No	No	Yes	Yes	4	3
267	4x38	4x40	Shared	50	18.9815	No	No	No	No	7	5
268	4x38	4x39	Shared	50	58.3333	No	No	No	No	7	4
269	7x31	7x35	Shared	50	20.8333	No	No	No	No	2	4
270	1x45	7x47	Shared	50	22.2222	No	No	No	No	4	6
271	5x36	5x38	Shared	16.6667	100	Yes	No	No	No	5	3
272	1x43	2x58	Shared	56.6667	42.1296	No	No	No	No	6	8
273	7x27	E2	Shared	50	0	No	No	Yes	Yes	3	3
274	5x40	6x55	Shared	50	33.3333	No	No	No	No	6	7
275	1x32	1x35	Shared	50	20.3704	No	No	No	No	6	3
276	5x43	Lig	Shared	0	100	No	No	Yes	Yes	6	0
277	4x65	E2	Shared	50	0	No	No	Yes	Yes	7	3
278	8x51	8x55	Shared	50	5.55556	No	No	No	No	9	3
279	1x51	2x51	Shared	50	100	No	No	No	No	3	7
280	6x35	6x39	Shared	50	41.6667	No	No	No	No	7	6
281	8x60	CT	Shared	50	0	No	No	Yes	No	8	3
282	1x48	1x49	Shared	0	0	No	No	No	No	4	8
283	4x44	4x48	Shared	0	0	No	No	No	No	3	2
284	6x42	6x46	Shared	50	16.6667	No	No	No	No	5	5
285	1x29	1x30	Shared	50	0	No	No	No	No	3	1
286	7x26	7x28	Shared	16.6667	16.6667	No	No	No	No	1	2
287	6x39	7x56	Shared	33.3333	37.5	No	No	No	No	6	7
288	5x37	6x59	Shared	16.6667	16.6667	No	No	No	No	4	5
289	2x42	4x42	Shared	0	100	Yes	Yes	No	No	8	7
290	1x60	8x56	Shared	16.6667	33.3333	No	Yes	No	No	6	4
291	5x56	5x60	Shared	0	100	No	No	No	No	5	5
292	6x43	7x48	Shared	0	43.0556	No	No	No	No	6	6
293	3x23	3x27	Shared	0	26.3889	No	No	No	No	1	4
294	5x41	5x42	Shared	16.6667	16.6667	No	No	No	No	6	4
295	1x41	1x45	Shared	16.6667	16.6667	No	No	No	No	4	4
296	3x56	I2x50	Shared	16.6667	0.925926	Yes	No	No	No	6	8
297	1x29	1x33	Shared	3.33333	0	No	No	No	No	3	5
298	6x29	6x32	Shared	16.6667	33.3333	No	No	No	No	6	8
299	1x40	2x61	Shared	0	25	No	No	No	No	3	6
300	6x41	6x42	Shared	0	0	Yes	No	No	No	8	5
301	1x40	1x44	Shared	0	0	No	No	No	No	3	4
302	6x57	6x61	Shared	0	31.9444	No	No	No	No	4	3
303	5x59	5x63	Shared	16.6667	30.5556	No	No	No	No	1	4
304	1x50	2x51	5ht_on	0	100	No	Yes	No	No	9	7
305	1x57	8x50	5ht_on	0	100	No	No	Yes	Yes	7	8
306	1x60	8x53	5ht_on	0	100	No	Yes	No	No	6	7
307	2x40	8x50	5ht_on	0	100	No	No	Yes	Yes	9	8
308	2x41	4x42	5ht_on	0	100	No	No	No	No	4	7
309	2x42	3x49	5ht_on	0	100	Yes	Yes	Yes	Yes	8	9
310	2x46	3x43	5ht_on	0	100	No	Yes	No	No	9	8
311	2x46	7x49	5ht_on	0	100	No	Yes	No	Yes	9	9
312	2x53	3x35	5ht_on	0	100	No	No	No	No	7	7
313	2x64	7x35	5ht_on	0	100	No	No	No	No	5	4
314	E1x49	E2	5ht_on	0	100	No	No	Yes	Yes	4	3
315	3x24	E1x50	5ht_on	0	100	No	Yes	Yes	Yes	5	7
316	E1x51	E1x52	5ht_on	0	100	No	No	Yes	No	3	5
317	3x29	E2x52	5ht_on	0	100	No	No	No	No	5	4
318	3x36	6x48	5ht_on	0	100	No	No	Yes	Yes	7	8
319	3x37	4x56	5ht_on	0	100	No	No	No	No	7	6
320	3x40	6x48	5ht_on	0	100	No	No	Yes	Yes	8	8
321	3x41	4x49	5ht_on	0	100	No	No	No	No	6	6
322	3x43	7x49	5ht_on	0	100	No	No	No	Yes	8	9
323	3x43	7x53	5ht_on	0	100	No	No	No	Yes	8	9
324	3x46	3x50	5ht_on	0	100	No	No	Yes	No	9	9
325	3x46	7x53	5ht_on	0	100	No	No	No	Yes	9	9
326	3x47	5x58	5ht_on	0	100	No	No	Yes	Yes	9	9
327	3x50	7x53	5ht_on	0	100	Yes	No	No	Yes	9	9
328	3x53	I2x53	5ht_on	0	100	No	No	Yes	Yes	8	7
329	3x54	5x61	5ht_on	0	100	No	No	No	No	9	9
330	I2x52	I2x56	5ht_on	0	100	No	No	No	No	5	4
331	4x60	5x39	5ht_on	0	100	No	No	No	No	7	7
332	5x39	E2	5ht_on	0	100	No	No	Yes	Yes	7	3
333	5x37	6x60	5ht_on	0	100	No	No	No	No	4	4
334	5x39	5x43	5ht_on	0	100	No	No	No	No	7	6
335	5x47	6x44	5ht_on	0	100	No	Yes	Yes	Yes	8	9
336	5x47	6x49	5ht_on	0	100	No	Yes	No	No	8	6
337	5x51	5x55	5ht_on	0	100	No	No	No	No	6	5
338	5x54	6x44	5ht_on	0	100	No	No	Yes	Yes	8	9
339	5x58	6x37	5ht_on	0	100	Yes	Yes	No	No	9	8
340	5x58	6x40	5ht_on	0	100	Yes	Yes	No	No	9	8
341	5x62	5x66	5ht_on	0	100	No	No	No	No	5	6
342	5x66	6x30	5ht_on	0	100	No	No	No	No	6	8
343	6x40	7x53	5ht_on	0	100	No	No	No	Yes	8	9
344	6x48	7x45	5ht_on	0	100	Yes	Yes	No	No	8	9
345	6x58	E3	5ht_on	0	100	No	No	No	Yes	4	3
346	7x34	E3	5ht_on	0	100	No	No	No	Yes	3	3
347	7x30	7x33	5ht_on	0	100	No	No	No	No	4	4
348	7x49	7x53	5ht_on	0	100	No	Yes	No	Yes	9	9
349	7x54	8x50	5ht_on	0	100	No	No	Yes	Yes	7	8
350	6x55	Lig	5ht_on	0	100	No	No	Yes	Yes	7	0
351	2x45	4x50	5ht_on	0	100	No	No	No	Yes	9	9
352	3x30	4x58	5ht_on	0	100	No	No	No	No	6	0
353	E2	E3	5ht_on	0	100	Yes	Yes	No	Yes	3	3
354	5x74	I3	5ht_on	0	100	No	No	No	Yes	0	0
355	2x62	2x66	5ht_on	0	37.5	No	No	No	No	4	4
356	5x62	6x34	5ht_on	0	66.6667	No	No	No	No	5	7
357	1x53	7x54	5ht_on	0	55.5556	No	No	No	No	9	7
358	5x40	6x59	5ht_on	0	58.3333	No	No	No	No	6	5
359	3x52	3x56	5ht_on	0	62.5	No	Yes	Yes	No	5	6
360	2x54	2x57	5ht_on	0	41.2037	No	No	Yes	Yes	6	8
361	5x461	Lig	5ht_on	0	37.5	No	No	Yes	Yes	6	0
362	1x56	8x54	5ht_on	0	41.6667	No	No	No	No	7	6
363	2x39	3x49	5ht_on	0	33.3333	No	No	Yes	Yes	8	9
364	7x30	E3	5ht_on	0	58.3333	No	No	No	Yes	4	3
365	1x46	1x50	5ht_on	0	56.9444	No	No	No	Yes	7	9
366	7x55	7x56	5ht_on	0	38.8889	No	No	No	No	5	7
367	6x43	7x52	5ht_on	0	47.2222	No	No	No	No	6	8
368	4x38	4x41	5ht_on	0	33.3333	No	No	No	No	7	6
369	2x48	2x52	5ht_on	0	17.1296	No	No	No	No	6	7
370	7x30	7x32	5ht_on	0	26.3889	No	No	No	No	4	1
371	2x55	2x551	5ht_on	0	24.537	No	No	No	No	4	5
372	8x50	8x54	5ht_on	0	33.3333	Yes	Yes	No	No	8	6
373	2x43	8x50	5ht_on	0	42.1296	No	No	Yes	Yes	8	8
374	5x62	6x37	5ht_on	0	55.5556	No	No	No	No	5	8
375	1x47	2x51	5ht_on	0	9.25926	No	No	No	No	5	7
376	3x26	E2	5ht_on	0	25	No	No	Yes	Yes	6	3
377	4x57	4x58	5ht_on	0	38.8889	No	No	No	No	7	0
378	1x60	8x52	5ht_on	0	16.6667	No	Yes	No	No	6	4
379	5x41	6x56	5ht_on	0	16.6667	No	No	No	No	6	5
380	2x65	2x66	5ht_on	0	31.4815	No	Yes	No	No	5	4
381	I2x51	I2x52	5ht_on	0	30.5556	No	No	No	No	7	5
382	1x35	2x65	5ht_on	0	17.1296	No	No	No	Yes	3	5
383	5x42	5x46	5ht_on	0	16.6667	No	No	No	No	4	4
384	1x55	1x59	5ht_on	0	26.3889	No	No	No	No	4	5
385	1x42	7x47	5ht_on	0	24.0741	No	No	No	No	7	6
386	5x67	5x71	5ht_on	0	26.3889	No	No	No	No	5	0
387	5x67	6x30	5ht_on	0	16.6667	No	No	No	No	5	8
388	E1	E1x49	5ht_on	0	22.2222	No	No	No	No	3	4
389	8x61	8x62	5ht_on	0	16.6667	No	No	No	No	0	0
390	5x69	6x30	5ht_on	0	22.2222	No	No	No	No	5	8
391	3x24	3x27	5ht_on	0	16.6667	No	Yes	No	No	5	4
392	1x49	7x51	5ht_on	0	20.8333	No	No	No	No	8	6
393	6x28	6x31	5ht_on	0	16.6667	No	No	Yes	No	6	5
394	6x39	7x52	5ht_on	0	16.6667	No	No	No	No	6	8
395	3x21	3x24	5ht_on	0	22.6852	No	No	No	Yes	7	5
396	1x49	1x52	5ht_on	0	16.6667	No	No	No	No	8	6
397	5x71	5x72	5ht_on	0	20.8333	No	No	No	No	0	0
398	1x33	1x35	5ht_on	0	16.6667	No	No	No	No	5	3
399	5x68	6x28	5ht_on	0	16.6667	No	No	No	No	7	6
400	1x38	1x42	5ht_on	0	16.6667	No	No	No	No	4	7
401	I2x53	I2x54	5ht_on	0	0	Yes	Yes	No	No	7	6
402	4x39	4x43	5ht_on	0	16.6667	No	No	No	No	4	4
403	1x39	2x65	5ht_on	0	16.6667	No	No	No	Yes	6	5
404	3x54	5x65	5ht_on	0	16.6667	No	No	No	No	9	8
405	6x32	6x36	5ht_on	0	16.6667	No	No	No	No	8	8
406	3x52	I2	5ht_on	0	16.6667	No	Yes	No	No	5	0
407	8x56	8x57	5ht_on	0	18.0556	No	No	Yes	No	4	4
408	8x58	8x59	5ht_on	0	25	No	No	No	No	6	4
409	1x52	8x58	5ht_on	0	20.8333	No	No	No	No	6	6
410	6x27	6x35	5ht_on	0	16.6667	No	No	No	No	5	7
411	4x43	4x47	5ht_on	0	16.6667	No	No	No	No	4	2
412	6x31	6x34	5ht_on	0	25	Yes	No	No	No	5	7
413	I1x49	I1x52	5ht_on	0	16.6667	No	No	No	No	6	0
414	5x65	6x33	5ht_on	0	0.462963	No	No	No	No	8	8
415	4x55	4x59	5ht_on	0	8.33333	No	No	No	No	4	4
416	5x66	5x70	5ht_on	0	16.6667	No	No	No	No	6	0
417	6x50	7x40	5ht_on	0	5.55556	No	No	No	No	9	7
418	I2x51	I2x55	5ht_on	0	18.9815	No	No	No	No	7	4
419	4x48	4x52	5ht_on	0	1.85185	No	No	No	No	2	5
420	4x35	I2x54	5ht_on	0	16.6667	No	No	No	No	0	6
421	4x51	4x55	5ht_on	0	9.72222	No	No	No	No	4	4
422	1x54	1x58	5ht_on	0	4.16667	No	No	No	No	6	1
423	2x66	2x67	5ht_on	0	0	No	No	No	No	4	5
424	8x47	8x48	5ht_on	0	4.16667	No	No	No	No	9	5
425	5x74	5x75	5ht_on	0	16.6667	No	No	No	No	0	0
426	1x33	1x37	5ht_on	0	2.31481	No	No	No	No	5	4
427	8x56	8x60	5ht_on	0	16.6667	No	No	No	No	4	8
428	5x52	5x56	5ht_on	0	2.31481	No	No	No	No	3	5
429	6x26	6x28	5ht_on	0	6.94444	No	No	No	No	5	6
430	1x32	1x34	5ht_on	0	0	No	No	No	No	6	4
431	6x14	6x16	5ht_on	0	4.16667	No	No	No	No	0	0
432	2x67	2x68	5ht_on	0	0	No	No	No	No	5	0
433	5x73	I3	5ht_on	0	4.16667	No	No	No	Yes	0	0
434	6x20	6x23	5ht_on	0	4.16667	No	No	No	No	0	0
435	5x76	I3	5ht_on	0	0	No	No	No	Yes	0	0
436	4x36	4x37	5ht_on	0	5.55556	No	No	No	No	0	0
437	5x68	I3	5ht_on	0	4.16667	No	No	No	Yes	7	0
438	1x31	1x32	5ht_on	0	4.16667	No	No	No	No	3	6
439	1x29	NT	5ht_on	0	4.16667	No	No	Yes	No	3	0
440	4x37	4x41	5ht_on	0	0	No	No	No	No	0	6
441	1x28	1x31	5ht_on	0	0	No	No	No	No	3	3
442	6x20	6x24	5ht_on	0	1.38889	No	No	No	No	0	0
443	6x19	6x23	5ht_on	0	1.85185	No	No	No	No	0	0
444	6x14	6x17	5ht_on	0	1.85185	No	No	No	No	0	0
445	6x23	6x27	5ht_on	0	1.38889	No	No	No	No	0	5
446	6x22	6x25	5ht_on	0	0.925926	No	No	No	No	0	5
447	6x18	6x22	5ht_on	0	0.462963	No	No	No	No	0	0
448	6x14	6x15	5ht_on	0	0.462963	No	No	No	No	0	0
449	6x16	6x20	5ht_on	0	0.462963	No	No	No	No	0	0
450	6x21	6x24	5ht_on	0	0	No	No	No	No	0	0

Orange: nodes, hubs and links specific of 5ht_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of 5ht_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	5ht_off Avg Int. Strength	5ht_on Avg Int. Strength	5ht_off Num Of Links	5ht_on Num Of Links	ConSurf
1	2x56	5ht_off	50	25	4	3	8
2	E1x52	5ht_off	0	0	4	3	5
3	3x28	5ht_off	50	11.1111	5	3	5
4	3x50	5ht_off	0	0	4	2	9
5	3x56	5ht_off	0	0	4	3	6
6	5x36	5ht_off	0	0	4	2	5
7	5x64	5ht_off	50	0	4	1	6
8	6x31	5ht_off	0	0	4	2	5
9	6x41	5ht_off	33.3333	0	6	2	8
10	6x51	5ht_off	100	31.9444	6	2	7
11	7x37	5ht_off	50	0	5	3	5
12	8x57	5ht_off	33.3333	0	4	2	4
13	CT	5ht_off	0	0	5	1	3
14	NT	5ht_off	83.3333	0	7	1	0
15	I1x50	Shared	33.3333	40.2778	4	4	8
16	2x42	Shared	16.6667	22.2222	4	5	8
17	2x50	Shared	83.3333	75.9259	5	5	9
18	2x57	Shared	100	40.2778	5	4	8
19	E1x50	Shared	100	83.3333	6	6	7
20	3x32	Shared	50	33.3333	4	4	8
21	3x42	Shared	83.3333	55.5556	5	4	8
22	3x49	Shared	50	0	4	4	9
23	3x51	Shared	50	34.2593	4	4	8
24	I2x53	Shared	50	44.4444	4	5	7
25	E2	Shared	100	99.0741	11	13	3
26	5x48	Shared	50	1.38889	5	4	5
27	5x58	Shared	0	66.6667	4	6	9
28	6x44	Shared	100	29.1667	4	4	9
29	6x48	Shared	100	83.3333	5	6	8
30	6x52	Shared	96.6667	69.4444	6	4	7
31	7x39	Shared	100	51.3889	6	5	6
32	7x42	Shared	100	100	7	5	7
33	8x50	Shared	50	83.3333	4	7	8
34	Lig	Shared	100	100	13	9	0
35	1x50	5ht_on	0	25	3	4	9
36	1x60	5ht_on	0	25	3	5	6
37	2x46	5ht_on	0	29.6296	2	4	9
38	2x65	5ht_on	0	0	2	4	5
39	3x24	5ht_on	0	16.6667	2	4	5
40	3x52	5ht_on	50	27.7778	2	4	5
41	4x50	5ht_on	83.3333	16.6667	3	4	9
42	5x47	5ht_on	50	77.7778	3	5	8
43	E3	5ht_on	0	27.7778	1	5	3
44	7x49	5ht_on	0	39.3519	3	5	9
45	7x53	5ht_on	0	98.1482	2	6	9
46	I3	5ht_on	0	0	0	4	0

Orange: nodes, hubs and links specific of 5ht_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of 5ht_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	5ht_off Recurrence	5ht_on Recurrence	5ht_off Hub1?	5ht_on Hub1?	5ht_off Hub2?	5ht_on Hub2?	ConSurf1	ConSurf2
1	1x46	2x57	5ht_off	21.6372	0	No	No	Yes	Yes	7	8
2	1x46	2x54	5ht_off	12.1207	0	No	No	No	No	7	6
3	2x56	7x42	5ht_off	52.4226	1.21107	Yes	No	Yes	Yes	8	7
4	2x53	2x56	5ht_off	38.3116	0	No	No	Yes	No	7	8
5	2x53	7x46	5ht_off	36.8943	6.82688	No	No	No	No	7	9
6	2x50	7x46	5ht_off	36.2394	7.94308	Yes	Yes	No	No	9	9
7	2x46	2x50	5ht_off	57.1348	1.08775	No	Yes	Yes	Yes	9	9
8	3x42	4x46	5ht_off	94.6431	0	Yes	Yes	No	No	8	8
9	2x42	4x46	5ht_off	93.5943	2.71304	Yes	Yes	No	No	8	8
10	2x42	3x45	5ht_off	89.3988	2.30514	Yes	Yes	No	No	8	7
11	3x45	4x45	5ht_off	87.9253	1.15415	No	No	No	No	7	6
12	3x49	4x45	5ht_off	82.1642	0	Yes	Yes	No	No	9	6
13	3x49	3x50	5ht_off	59.4014	0	Yes	Yes	Yes	No	9	9
14	2x39	3x50	5ht_off	54.7915	0	No	No	Yes	No	8	9
15	2x37	2x39	5ht_off	53.2003	0	No	No	No	No	7	8
16	2x37	2x40	5ht_off	51.5477	1.18893	No	No	No	No	7	9
17	2x40	I1x50	5ht_off	44.835	0.0790514	No	No	Yes	Yes	9	8
18	1x56	8x50	5ht_off	28.2988	0	No	No	Yes	Yes	7	8
19	1x52	1x56	5ht_off	24.6815	0	No	No	No	No	6	7
20	7x42	Lig	5ht_off	100	0	Yes	Yes	Yes	Yes	7	0
21	3x37	Lig	5ht_off	51.6654	0	No	No	Yes	Yes	7	0
22	3x37	4x53	5ht_off	48.923	1.53043	No	No	No	No	7	8
23	3x38	4x53	5ht_off	47.782	0	No	No	No	No	8	8
24	3x38	4x50	5ht_off	46.7281	1.46719	No	No	No	Yes	8	9
25	3x42	4x50	5ht_off	45.2341	4.04743	Yes	Yes	No	Yes	8	9
26	1x52	8x57	5ht_off	19.4935	0	No	No	Yes	No	6	4
27	3x49	I2x57	5ht_off	16.5874	1.95731	Yes	Yes	No	No	9	6
28	2x38	I2x57	5ht_off	15.3287	1.13518	No	No	No	No	5	6
29	2x38	4x39	5ht_off	13.4971	0	No	No	No	No	5	4
30	6x48	Lig	5ht_off	28.2169	0	Yes	Yes	Yes	Yes	8	0
31	6x44	7x45	5ht_off	45.7611	0	Yes	Yes	No	No	9	9
32	3x40	Lig	5ht_off	66.6871	0	No	No	Yes	Yes	8	0
33	3x40	6x44	5ht_off	38.6339	0.0474308	No	No	Yes	Yes	8	9
34	3x33	4x57	5ht_off	22.2103	9.10356	No	No	No	No	6	7
35	3x34	4x57	5ht_off	16.4288	3.05771	No	No	No	No	6	7
36	2x60	3x28	5ht_off	36.9557	0	No	No	Yes	No	7	5
37	3x28	E1x50	5ht_off	93.7375	8.98972	Yes	No	Yes	Yes	5	7
38	E1x50	E1x52	5ht_off	21.1768	1.86245	Yes	Yes	Yes	No	7	5
39	3x25	E1x50	5ht_off	57.6516	0.942293	No	No	Yes	Yes	9	7
40	3x24	E1x52	5ht_off	10.6319	0.0221344	No	Yes	Yes	No	5	5
41	3x25	E2	5ht_off	54.3106	0	No	No	Yes	Yes	9	3
42	3x40	5x50	5ht_off	52.484	0	No	No	No	No	8	9
43	3x41	5x50	5ht_off	48.9946	2.93755	No	No	No	No	6	9
44	3x41	3x44	5ht_off	37.2474	0	No	No	No	No	6	6
45	3x43	6x44	5ht_off	62.1489	0	No	No	Yes	Yes	8	9
46	3x44	5x53	5ht_off	43.4433	1.27115	No	No	No	No	6	6
47	3x43	6x41	5ht_off	59.9335	0	No	No	Yes	No	8	8
48	5x54	6x41	5ht_off	13.9524	0	No	No	Yes	No	8	8
49	3x44	5x54	5ht_off	12.4533	2.53913	No	No	No	No	6	8
50	5x53	5x57	5ht_off	41.0386	0	No	No	No	No	6	5
51	3x51	3x55	5ht_off	24.7787	2.15336	Yes	Yes	No	No	8	6
52	3x55	5x64	5ht_off	12.2333	0.964427	No	No	Yes	No	6	6
53	3x55	3x56	5ht_off	10.2481	0	No	No	Yes	No	6	6
54	3x41	4x52	5ht_off	12.6733	4.39842	No	No	No	No	6	5
55	5x36	E2	5ht_off	27.0606	3.05771	Yes	No	Yes	Yes	5	3
56	5x36	5x39	5ht_off	20.1484	0	Yes	No	No	No	5	7
57	5x58	6x41	5ht_off	37.1348	3.55099	Yes	Yes	Yes	No	9	8
58	5x58	5x62	5ht_off	27.5774	0	Yes	Yes	No	No	9	5
59	5x62	6x31	5ht_off	24.9885	0	No	No	Yes	No	5	5
60	6x31	6x32	5ht_off	12.6222	0	Yes	No	No	No	5	8
61	6x40	7x49	5ht_off	12.704	0	No	No	No	Yes	8	9
62	7x38	7x42	5ht_off	13.6812	0.850593	No	No	Yes	Yes	6	7
63	6x51	7x38	5ht_off	13.3947	1.52727	Yes	No	No	No	7	6
64	6x51	Lig	5ht_off	30.33	2.82372	Yes	No	Yes	Yes	7	0
65	6x51	7x34	5ht_off	44.3796	0	Yes	No	No	No	7	3
66	6x54	7x34	5ht_off	27.782	7.60158	No	No	No	No	5	3
67	6x54	7x37	5ht_off	16.7869	6.09328	No	No	Yes	No	5	5
68	6x58	7x34	5ht_off	15.0166	0.0158103	No	No	No	No	4	3
69	6x61	7x30	5ht_off	13.758	0	No	No	No	No	3	4
70	8x57	CT	5ht_off	14.2287	0	Yes	No	Yes	No	4	3
71	1x42	2x57	5ht_off	16.3776	0	No	No	Yes	Yes	7	8
72	1x42	7x43	5ht_off	12.1207	0	No	No	No	No	7	4
73	2x64	7x39	5ht_off	38.7363	2.60237	No	No	Yes	Yes	5	6
74	2x64	E1	5ht_off	37.0888	0	No	No	No	No	5	3
75	7x35	E1	5ht_off	35.4925	0	No	No	No	No	4	3
76	7x35	NT	5ht_off	31.9007	0	No	No	Yes	No	4	0
77	1x32	NT	5ht_off	16.2139	0	No	No	Yes	No	6	0
78	1x32	1x35	5ht_off	10.0588	3.08617	No	No	No	No	6	3
79	2x57	7x42	5ht_off	38.5674	3.42451	Yes	Yes	Yes	Yes	8	7
80	2x60	7x42	5ht_off	31.3993	0	No	No	Yes	Yes	7	7
81	3x32	Lig	5ht_off	26.8969	9.30277	Yes	Yes	Yes	Yes	8	0
82	7x39	7x42	Shared	41.3405	19.2664	Yes	Yes	Yes	Yes	6	7
83	1x50	2x50	Shared	14.2799	15.5794	No	Yes	Yes	Yes	9	9
84	2x46	3x42	Shared	56.1422	16.7336	No	Yes	Yes	Yes	9	8
85	8x50	I1x50	Shared	35.0115	13.9036	Yes	Yes	Yes	Yes	8	8
86	2x50	7x49	Shared	39.2172	23.8514	Yes	Yes	No	Yes	9	9
87	6x44	6x48	Shared	35.2571	10.7984	Yes	Yes	Yes	Yes	9	8
88	7x45	7x49	Shared	42.4047	99.8862	No	No	No	Yes	9	9
89	3x33	Lig	Shared	24.2415	10.5992	No	No	Yes	Yes	6	0
90	3x51	5x57	Shared	36.1934	11.2538	Yes	Yes	No	No	8	5
91	6x52	Lig	Shared	14.9092	35.5162	Yes	Yes	Yes	Yes	7	0
92	6x40	7x52	Shared	10.6114	23.8261	No	No	No	No	8	8
93	2x56	3x28	Shared	66.8662	10.536	Yes	No	Yes	No	8	5
94	2x56	3x32	Shared	26.5797	10.1628	Yes	No	Yes	Yes	8	8
95	5x43	Lig	5ht_on	2.13865	42.2957	No	No	Yes	Yes	6	0
96	1x39	7x39	5ht_on	1.69353	15.8735	No	No	Yes	Yes	6	6
97	3x32	7x42	5ht_on	0.480941	22.6656	Yes	Yes	Yes	Yes	8	7
98	6x48	7x45	5ht_on	0	100	Yes	Yes	No	No	8	9
99	3x36	6x48	5ht_on	0	53.3723	No	No	Yes	Yes	7	8
100	3x32	3x36	5ht_on	0.475825	24.1866	Yes	Yes	No	No	8	7
101	2x43	8x50	5ht_on	0	35.1368	No	No	Yes	Yes	8	8
102	2x43	7x53	5ht_on	1.91353	36.1455	No	No	No	Yes	8	9
103	7x49	7x53	5ht_on	0	90.419	No	Yes	No	Yes	9	9
104	1x60	I1x50	5ht_on	5.46943	11.8988	No	Yes	Yes	Yes	6	8
105	2x41	4x42	5ht_on	0	11.8609	No	No	No	No	4	7
106	2x42	4x42	5ht_on	1.93911	12.9486	Yes	Yes	No	No	8	7
107	2x42	3x46	5ht_on	1.94423	32.5281	Yes	Yes	No	No	8	9
108	3x46	7x53	5ht_on	0	33.1099	No	No	No	Yes	9	9
109	2x42	3x49	5ht_on	0	18.0269	Yes	Yes	Yes	Yes	8	9
110	2x46	7x49	5ht_on	0	12.8221	No	Yes	No	Yes	9	9
111	5x39	5x43	5ht_on	0	40.9581	No	No	No	No	7	6
112	5x39	E2	5ht_on	0	34.1755	No	No	Yes	Yes	7	3
113	3x42	4x49	5ht_on	1.95446	10.1787	Yes	Yes	No	No	8	6
114	6x40	7x53	5ht_on	0	57.6917	No	No	No	Yes	8	9
115	5x58	6x40	5ht_on	0	37.6474	Yes	Yes	No	No	9	8
116	3x47	5x58	5ht_on	0	13.5115	No	No	Yes	Yes	9	9
117	3x47	5x57	5ht_on	2.57355	12.3858	No	No	No	No	9	5
118	3x49	I2x53	5ht_on	9.8286	13.9415	Yes	Yes	Yes	Yes	9	7
119	5x47	6x52	5ht_on	8.6416	11.2221	No	Yes	Yes	Yes	8	7
120	5x58	6x37	5ht_on	0	18.9312	Yes	Yes	No	No	9	8
121	5x62	6x37	5ht_on	0	17.8372	No	No	No	No	5	8
122	E2	E3	5ht_on	0	19.0735	Yes	Yes	No	Yes	3	3
123	6x39	7x52	5ht_on	0	19.6047	No	No	No	No	6	8
124	1x39	2x65	5ht_on	0	12.7336	No	No	No	Yes	6	5
125	6x35	6x39	5ht_on	2.13865	10.4253	No	No	No	No	7	6
126	3x36	Lig	5ht_on	1.38143	28.8791	No	No	Yes	Yes	7	0
127	6x48	6x52	5ht_on	2.81914	39.9368	Yes	Yes	Yes	Yes	8	7

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
2x56	3x32	Shared	10.0307	7.20569	1	1	2	1
2x56	7x42	Shared	4.54533	3.92278	1	1	2	1
2x57	7x39	Shared	6.01133	3.30472	1	1	2	2
2x57	7x42	Shared	4.26733	6.76958	1	1	2	1
2x60	7x39	Shared	7.68	3.03662	1	0	2	2
2x60	7x42	5ht_off	4.50333	0	1	0	2	1
3x32	3x36	Shared	3.46367	3.20361	1	1	1	1
3x32	7x42	Shared	9.50133	9.56162	1	1	1	1
3x32	Lig	Shared	13.7737	12.4516	1	1	1	0
3x33	4x57	Shared	3.40767	4.35338	0	0	1	2
3x33	Lig	Shared	6.20733	11.9719	0	0	1	0
3x36	Lig	Shared	8.071	7.7237	1	1	1	0
3x37	4x53	Shared	4.69333	5.49074	0	0	1	2
3x37	5x461	Shared	4.88233	3.71366	0	0	1	1
3x37	Lig	5ht_off	4.379	0	0	0	1	0
3x40	5x50	5ht_off	4.74267	0	0	1	1	2
3x40	6x44	Shared	8.33	4.10468	0	1	1	2
5x44	5x48	Shared	4.264	3.5762	1	0	1	2
5x44	6x52	Shared	3.715	4.18972	1	0	1	1
5x44	Lig	5ht_off	3.32067	0	1	0	1	0
5x47	5x48	Shared	8.81967	6.11153	1	0	2	2
5x47	6x52	Shared	30.184	21.2009	1	0	2	1
6x44	6x48	Shared	4.37667	4.2087	0	1	2	1
6x44	7x45	5ht_off	8.10867	0	0	1	2	2
6x48	6x51	5ht_off	7.85133	0	1	1	1	1
6x48	6x52	Shared	5.91133	6.09727	1	1	1	1
6x48	7x41	Shared	12.435	7.69768	1	1	1	2
6x48	Lig	5ht_off	13.838	0	1	1	1	0
6x51	6x52	5ht_off	9.21833	0	1	0	1	1
6x51	7x34	5ht_off	4.005	0	1	0	1	2
6x51	7x38	Shared	6.20433	5.07778	1	0	1	1
6x51	Lig	Shared	13.7973	11.0567	1	0	1	0
6x52	Lig	Shared	12.8663	7.75282	1	0	1	0
7x38	7x42	Shared	5.47533	8.48653	1	0	1	1
7x38	Lig	5ht_off	5.072	0	1	0	1	0
7x39	7x42	Shared	8.391	7.25292	1	1	2	1
7x42	Lig	5ht_off	4.418	0	1	1	1	0
3x40	Lig	5ht_off	3.80533	0	0	1	1	0
5x48	6x52	5ht_off	3.80833	0	1	0	2	1
6x51	6x55	5ht_off	3.262	0	1	0	1	1
E2x52	Lig	Shared	3.07333	3.53782	0	0	1	0
5x40	6x55	Shared	2.436	2.04417	0	0	2	1
5x43	Lig	Shared	2.129	4.92486	0	0	1	0
3x29	E2x52	5ht_on	0	4.70514	0	0	2	1
3x36	6x48	5ht_on	0	4.98449	1	1	1	1
3x37	4x56	5ht_on	0	3.61	0	0	1	2
3x40	6x48	5ht_on	0	5.56782	0	1	1	1
5x39	5x43	5ht_on	0	6.8062	0	3	2	1
5x47	6x44	5ht_on	0	4.67134	1	0	2	2
6x48	7x45	5ht_on	0	9.8038	1	1	1	2
6x55	Lig	5ht_on	0	7.18421	0	0	1	0
5x461	Lig	5ht_on	0	2.84954	0	0	1	0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	5ht_off	5ht2_off 5ht1_off
	5ht_on	5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on

Network Difference
Value	5ht_off	5ht_on
I_min	3.30567	3.18347
Number of Linked Nodes	275	297
Number of Specific Nodes	5 (1.82%)	27 (9.09%)
Number of Shared Nodes	270 (98.18%)	270 (90.91%)
Number of Links	303	315
Number of Specific Links	135 (44.55%)	147 (46.67%)
Number of Shared Links	168 (55.45%)	168 (53.33%)
Number of Hubs	34	32
Number of Specific Hubs	14 (41.18%)	12 (37.50%)
Number of Shared Hubs	20 (58.82%)	20 (62.50%)
Average % Shared Neighbours (Jaccard)	40.50
Average % Shared Neighbours (Otsuka)	49.56
Average % Shared Neighbours (Overlap Coefficient)	58.73
Average % Shared Cliques (k3-6)	54.17
Graphlets Similarity	0.54205

Paths Difference
Value	5ht_off	5ht_on
Number Of Nodes in MetaPath	89	46
Specific Nodes in MetaPath	61 (68.54%)	18 (39.13%)
Shared Nodes in MetaPath	270 (98.18%)	270 (98.18%)
Number Of Links MetaPath	94	46
Specific Links in MetaPath	81 (86.17%)	33 (71.74%)
Shared Links in MetaPath	168 (55.45%)	168 (55.45%)
Number of Shortest Paths	62345	54860
Length Of Smallest Path	3	3
Average Path Length	14.1387	12.4967
Length of Longest Path	36	26
Minimum Path Strength	0.3725	0.246173
Average Path Strength	5.30871	4.87082
Maximum Path Strength	21.5252	14.4769
Minimum Path Correlation	0.701667	0.701111
Average Path Correlation	0.915627	0.907999
Maximum Path Correlation	0.99	0.99
Minimum % Of Corr. Nodes	3.22581	4.54545
Average % Of Corr. Nodes	43.9021	42.6261
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	41.6957	43.4116
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

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