psnGPCR

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Orange: nodes, hubs and links specific of a1_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of a1_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	a1_off Int. Strength	a1_on Int. Strength	a1_off Hub1?	a1_on Hub1?	a1_off Hub2?	a1_on Hub2?	ConSurf1	ConSurf2
1	1x35	7x39	a1_off	4.125	0	Yes	Yes	No	Yes	5	5
2	1x35	Lig	a1_off	5.215	0	Yes	Yes	Yes	Yes	5	0
3	1x45	7x47	a1_off	3.39	0	No	No	No	No	4	6
4	1x49	7x50	a1_off	4.06	0	No	No	No	No	8	9
5	1x50	2x47	a1_off	3.91	0	Yes	No	No	No	9	9
6	1x51	2x51	a1_off	3.21	0	No	No	No	No	5	7
7	1x53	7x53	a1_off	5.05	0	No	No	Yes	Yes	9	9
8	1x55	8x57	a1_off	9.985	0	Yes	No	No	No	4	7
9	1x55	8x61	a1_off	4.23	0	Yes	No	No	No	4	6
10	1x57	I1x50	a1_off	4.47	0	No	No	Yes	No	8	8
11	1x57	2x40	a1_off	3.275	0	No	No	No	Yes	8	8
12	2x37	3x53	a1_off	9.525	0	No	No	Yes	No	7	8
13	2x38	3x49	a1_off	3.86	0	No	No	No	No	6	9
14	2x39	3x50	a1_off	10.35	0	No	No	Yes	No	8	9
15	2x42	3x46	a1_off	5.02	0	Yes	Yes	No	No	8	9
16	2x43	7x53	a1_off	7.855	0	No	No	Yes	Yes	8	9
17	2x45	4x50	a1_off	4.325	0	No	No	No	No	9	9
18	2x54	2x57	a1_off	4.41	0	No	No	Yes	Yes	7	6
19	2x551	2x59	a1_off	3.46	0	No	No	No	No	5	5
20	2x56	3x32	a1_off	4.81	0	No	No	No	No	6	6
21	2x59	3x28	a1_off	7.45	0	No	No	No	No	5	6
22	2x63	E2x50	a1_off	4.09	0	No	No	No	No	3	9
23	E1x52	E2x50	a1_off	3.38	0	No	No	No	No	7	9
24	3x21	3x23	a1_off	8.165	0	No	No	Yes	No	6	1
25	3x23	3x24	a1_off	6.845	0	Yes	No	No	No	1	5
26	3x23	E2.E164	a1_off	9.85	0	Yes	No	No	No	1	3
27	3x29	E2.I175	a1_off	3.25	0	No	No	Yes	No	4	3
28	3x33	5x40	a1_off	4.24	0	No	Yes	Yes	No	4	5
29	3x37	4x56	a1_off	6.445	0	Yes	Yes	No	No	6	5
30	3x39	6x44	a1_off	5.285	0	No	No	Yes	No	9	9
31	3x41	4x52	a1_off	4.845	0	No	No	No	No	4	4
32	3x43	6x44	a1_off	5.48	0	No	No	Yes	No	8	9
33	3x44	5x54	a1_off	5.65	0	No	No	No	No	7	8
34	3x46	6x37	a1_off	3.665	0	No	No	No	No	9	8
35	3x47	5x54	a1_off	3.22	0	No	No	No	No	9	8
36	3x50	3x53	a1_off	12.795	0	Yes	No	Yes	No	9	8
37	3x50	6x30	a1_off	8.14	0	Yes	No	No	No	9	6
38	3x50	6x33	a1_off	9.395	0	Yes	No	No	No	9	7
39	3x51	5x61	a1_off	3.155	0	No	No	No	No	7	9
40	3x53	6x30	a1_off	11.045	0	Yes	No	No	No	8	6
41	3x54	5x61	a1_off	4.81	0	No	No	No	No	9	9
42	I2x52	I2x56	a1_off	4.575	0	No	No	No	No	5	4
43	4x54	4x58	a1_off	3.045	0	No	No	No	No	3	4
44	5x36	E2.W146	a1_off	5.56	0	No	No	No	Yes	5	6
45	E2.K173	E2.V152	a1_off	3.795	0	No	No	No	No	3	1
46	E2.E153	E2.P165	a1_off	3.14	0	No	No	Yes	No	2	5
47	E2.K168	E2x51	a1_off	4.725	0	No	No	No	No	3	4
48	5x37	6x58	a1_off	4.515	0	No	No	No	No	3	4
49	5x38	5x411	a1_off	4.49	0	No	No	No	No	3	4
50	5x39	5x43	a1_off	4.65	0	Yes	Yes	No	No	6	5
51	5x40	6x55	a1_off	4.91	0	Yes	No	No	No	5	5
52	5x40	Lig	a1_off	3.585	0	Yes	No	Yes	Yes	5	0
53	5x41	5x45	a1_off	4.585	0	No	No	No	No	4	4
54	5x41	6x56	a1_off	5.975	0	No	No	No	No	4	5
55	5x58	6x38	a1_off	3.335	0	No	Yes	No	No	9	6
56	5x63	5x67	a1_off	4.18	0	No	No	No	No	4	4
57	5x65	6x31	a1_off	4.995	0	No	No	No	No	8	5
58	5x68	6x27	a1_off	9.985	0	No	No	No	No	7	1
59	5x69	6x27	a1_off	3.46	0	No	No	No	No	4	1
60	6x32	8x48	a1_off	3.39	0	No	No	No	No	7	4
61	6x40	7x49	a1_off	4.96	0	No	No	Yes	Yes	8	9
62	6x44	7x45	a1_off	6.645	0	Yes	No	Yes	No	9	9
63	6x48	Lig	a1_off	4.825	0	Yes	Yes	Yes	Yes	8	0
64	6x54	7x34	a1_off	3.685	0	No	No	No	No	4	4
65	6x57	E3.K265	a1_off	3.635	0	No	No	No	Yes	4	3
66	6x58	Lig	a1_off	3.805	0	No	No	Yes	Yes	4	0
67	7x34	Lig	a1_off	3.735	0	No	No	Yes	Yes	4	0
68	7x35	Lig	a1_off	8.94	0	Yes	Yes	Yes	Yes	3	0
69	7x41	7x42	a1_off	3.47	0	No	No	Yes	Yes	7	7
70	7x45	7x48	a1_off	4.205	0	Yes	No	No	No	9	6
71	7x49	7x53	a1_off	3.49	0	Yes	Yes	Yes	Yes	9	9
72	7x53	8x47	a1_off	7.86	0	Yes	Yes	No	No	9	8
73	7x53	8x50	a1_off	4.125	0	Yes	Yes	Yes	Yes	9	9
74	8x47	8x50	a1_off	3.77	0	No	No	Yes	Yes	8	9
75	8x50	8x54	a1_off	4.285	0	Yes	Yes	No	No	9	7
76	8x58	8x63	a1_off	9.495	0	No	No	No	No	5	4
77	1x58	2x44	a1_off	3.035	0	No	No	No	No	3	5
78	6x26	6x30	a1_off	8.415	0	No	No	No	No	3	6
79	6x29	8x50	a1_off	7.445	0	No	No	Yes	Yes	6	9
80	6x32	8x50	a1_off	4.965	0	No	No	Yes	Yes	7	9
81	7x56	8x49	a1_off	3.715	0	Yes	No	No	No	7	6
82	2x53	3x35	a1_off	2.98	0	No	No	No	No	8	7
83	5x47	5x51	a1_off	2.98	0	No	No	No	No	5	6
84	6x26	6x27	a1_off	2.98	0	No	No	No	No	3	1
85	1x38	1x42	a1_off	2.94	0	No	No	No	No	5	7
86	1x42	2x57	a1_off	2.94	0	No	No	Yes	Yes	7	6
87	3x55	3x56	a1_off	2.905	0	No	No	Yes	No	7	6
88	E1x51	E2.V166	a1_off	2.87	0	No	No	No	No	4	3
89	1x36	2x64	a1_off	2.83	0	No	No	No	No	5	3
90	5x62	6x38	a1_off	2.77	0	Yes	No	No	No	6	6
91	8x56	8x60	a1_off	2.765	0	No	No	No	No	5	6
92	8x48	8x49	a1_off	2.71	0	No	No	No	No	4	6
93	5x69	6x24	a1_off	2.66	0	No	No	No	No	4	2
94	6x61	E3.S262	a1_off	2.58	0	No	No	No	No	4	3
95	5x62	6x35	a1_off	2.48	0	Yes	No	No	No	6	7
96	6x35	7x56	a1_off	2.48	0	No	No	Yes	No	7	7
97	2x41	4x46	a1_off	2.455	0	No	No	No	No	4	8
98	5x44	6x49	a1_off	2.44	0	Yes	Yes	No	No	5	7
99	5x62	6x31	a1_off	2.44	0	Yes	No	No	No	6	5
100	2x63	3x28	a1_off	2.305	0	No	No	No	No	3	6
101	6x40	7x52	a1_off	2.305	0	No	No	No	No	8	8
102	5x60	5x63	a1_off	2.245	0	No	No	No	No	4	4
103	1x52	8x57	a1_off	2.14	0	No	No	No	No	7	7
104	5x53	5x57	a1_off	2.14	0	No	No	No	No	6	6
105	7x55	7x56	a1_off	2.14	0	No	No	Yes	No	6	7
106	2x62	2x65	a1_off	2.14	0	No	No	No	No	4	4
107	1x31	7x35	a1_off	2.065	0	No	No	Yes	Yes	4	3
108	E2.K173	E2x51	a1_off	2.025	0	No	No	No	No	3	4
109	8x59	8x60	a1_off	2.02	0	No	No	No	No	4	6
110	5x69	6x28	a1_off	1.995	0	No	No	No	No	4	3
111	8x60	8x61	a1_off	1.89	0	No	No	No	No	6	6
112	6x50	7x37	a1_off	1.87	0	No	No	No	No	9	5
113	1x47	2x54	a1_off	1.84	0	No	No	No	No	6	7
114	2x49	3x39	a1_off	1.71	0	No	No	No	No	8	9
115	3x33	4x57	a1_off	1.71	0	No	Yes	No	No	4	6
116	E2.A159	E2.S161	a1_off	1.71	0	No	No	No	No	6	6
117	1x56	8x53	a1_off	1.68	0	No	No	No	No	8	6
118	3x25	E2.I167	a1_off	1.635	0	No	No	No	No	9	4
119	1x40	2x61	a1_off	1.54	0	No	No	No	No	4	6
120	1x55	8x62	a1_off	1.505	0	Yes	No	No	No	4	3
121	6x47	7x40	a1_off	1.5	0	No	No	No	No	8	7
122	1x36	2x65	a1_off	1.47	0	No	No	No	No	5	4
123	3x56	I2x51	a1_off	1.425	0	Yes	No	No	No	6	6
124	7x54	8x54	a1_off	1.385	0	No	No	No	No	7	7
125	5x52	5x56	a1_off	1.385	0	No	No	No	No	3	4
126	4x41	I2x56	a1_off	1.31	0	No	No	No	No	5	4
127	7x51	7x55	a1_off	1.255	0	No	No	No	No	7	6
128	4x58	4x62	a1_off	1.22	0	No	No	No	No	4	4
129	2x38	4x42	a1_off	0.895	0	No	No	No	No	6	7
130	E2.A151	E2.S150	a1_off	0.855	0	No	No	No	No	3	2
131	1x47	2x55	a1_off	0.85	0	No	No	No	No	6	4
132	4x47	4x51	a1_off	0.81	0	No	No	No	No	4	4
133	8x52	8x53	a1_off	0.795	0	No	No	No	No	4	6
134	4x51	4x55	a1_off	0.77	0	No	No	No	No	4	4
135	7x30	E3.H264	a1_off	0.765	0	No	No	No	No	4	2
136	1x41	1x45	a1_off	0.745	0	No	No	No	No	5	4
137	5x55	5x59	a1_off	0.745	0	No	No	No	No	5	3
138	E2.G163	E2.W156	a1_off	0.705	0	No	No	Yes	No	4	1
139	E2.A151	E2.R154	a1_off	0.69	0	No	No	No	No	3	2
140	5x52	5x53	a1_off	0.69	0	No	No	No	No	3	6
141	4x40	4x44	a1_off	0.655	0	No	No	No	No	5	3
142	8x55	8x58	a1_off	0.57	0	No	No	No	No	5	5
143	1x32	2x64	Shared	10.56	7.92	No	Yes	No	No	4	3
144	1x35	1x39	Shared	15.15	17.96	Yes	Yes	No	Yes	5	6
145	1x35	2x64	Shared	10.465	6.98	Yes	Yes	No	No	5	3
146	1x35	7x35	Shared	5.96	5.96	Yes	Yes	Yes	Yes	5	3
147	1x36	2x61	Shared	3.68	11.77	No	No	No	No	5	6
148	1x38	7x39	Shared	11.305	12.56	No	No	No	Yes	5	5
149	1x39	2x57	Shared	8.88	8.2	No	Yes	Yes	Yes	6	6
150	1x39	7x42	Shared	10.465	12.31	No	Yes	Yes	Yes	6	7
151	1x43	2x57	Shared	4.87	4.87	No	No	Yes	Yes	5	6
152	1x46	7x46	Shared	4.075	4.89	No	No	No	No	8	9
153	1x47	1x48	Shared	4.415	5.3	No	No	No	No	6	4
154	1x50	2x50	Shared	12.79	6.73	Yes	No	Yes	Yes	9	9
155	1x50	7x50	Shared	12.215	11.4	Yes	No	No	No	9	9
156	1x52	8x54	Shared	6.09	4.87	No	No	No	No	7	7
157	1x53	2x47	Shared	3.39	3.39	No	No	No	No	9	9
158	1x53	7x50	Shared	3.53	3.53	No	No	No	No	9	9
159	1x54	2x47	Shared	3.25	3.25	No	No	No	No	7	9
160	1x54	2x48	Shared	3.84	1.54	No	No	No	No	7	6
161	1x55	1x59	Shared	7.97	6.13	Yes	No	No	No	4	5
162	1x57	2x44	Shared	4.01	3.21	No	No	No	No	8	5
163	1x60	I1x50	Shared	7.555	6.87	No	No	Yes	No	6	8
164	2x40	I1x50	Shared	12.79	18.27	No	Yes	Yes	No	8	8
165	2x37	2x40	Shared	3.585	7.17	No	No	No	Yes	7	8
166	2x39	3x49	Shared	7.225	8.67	No	No	No	No	8	9
167	2x42	3x45	Shared	8.32	2.77	Yes	Yes	No	No	8	7
168	2x42	4x46	Shared	5.02	3.77	Yes	Yes	No	No	8	8
169	2x45	4x46	Shared	4.645	9.29	No	No	No	No	9	8
170	2x46	2x50	Shared	4.07	6.79	No	Yes	Yes	Yes	9	9
171	2x50	7x46	Shared	8.83	4.42	Yes	Yes	No	No	9	9
172	2x50	7x49	Shared	5.385	10.77	Yes	Yes	Yes	Yes	9	9
173	2x52	3x35	Shared	4.44	3.15	No	No	No	No	6	7
174	2x53	2x56	Shared	9.62	6.41	No	No	No	No	8	6
175	2x53	7x46	Shared	8.08	8.08	No	No	No	No	8	9
176	2x56	7x42	Shared	3.46	4.15	No	No	Yes	Yes	6	7
177	2x57	2x58	Shared	3.39	3.39	Yes	Yes	No	No	6	8
178	2x57	7x42	Shared	4.64	6.63	Yes	Yes	Yes	Yes	6	7
179	2x66	E1x50	Shared	4.06	4.06	No	No	No	No	3	3
180	3x24	E1x52	Shared	7.065	3.14	No	No	No	No	5	7
181	3x21	3x24	Shared	3.745	2.5	No	No	No	No	6	5
182	3x21	E2.E164	Shared	9.54	7.86	No	No	No	No	6	3
183	3x22	3x26	Shared	3.655	3.65	Yes	Yes	No	No	3	5
184	3x22	E2.N147	Shared	6.645	4.83	Yes	Yes	Yes	Yes	3	6
185	3x22	E2.L149	Shared	13.395	4.87	Yes	Yes	No	No	3	4
186	3x22	E2.V152	Shared	4.585	3.93	Yes	Yes	No	No	3	1
187	3x22	E2.V174	Shared	6.555	6.55	Yes	Yes	No	Yes	3	3
188	3x25	E2x50	Shared	7.28	7.28	No	No	No	No	9	9
189	3x25	E2.V174	Shared	8.54	5.12	No	No	No	Yes	9	3
190	3x26	E2.N147	Shared	6.87	6.87	No	No	Yes	Yes	5	6
191	3x27	4x61	Shared	5.055	4.33	No	No	No	No	4	5
192	3x30	4x61	Shared	3.24	4.86	No	No	No	No	6	5
193	3x32	Lig	Shared	6.61	6.87	No	No	Yes	Yes	6	0
194	3x33	5x39	Shared	6.45	5.86	No	Yes	Yes	Yes	4	6
195	3x34	4x54	Shared	9.42	12.56	No	Yes	No	No	5	3
196	3x36	6x48	Shared	9.785	3.64	No	No	Yes	Yes	6	8
197	3x37	3x40	Shared	4.8	4.12	Yes	Yes	No	Yes	6	8
198	3x37	3x41	Shared	4.655	7.99	Yes	Yes	No	No	6	4
199	3x37	4x53	Shared	5.055	2.89	Yes	Yes	No	No	6	8
200	3x37	5x461	Shared	6.025	7.67	Yes	Yes	Yes	Yes	6	8
201	3x38	4x50	Shared	12.97	12.36	No	No	No	No	7	9
202	3x38	4x53	Shared	4.89	4.89	No	No	No	No	7	8
203	3x40	5x50	Shared	3.39	3.39	No	Yes	No	No	8	8
204	3x40	6x44	Shared	5.65	6.28	No	Yes	Yes	No	8	9
205	3x41	4x49	Shared	4.76	3.17	No	No	No	No	4	7
206	3x47	5x57	Shared	4.87	3.25	No	No	No	No	9	6
207	3x47	5x58	Shared	5.34	4	No	No	No	Yes	9	9
208	3x49	I2x53	Shared	9.195	5.75	No	No	Yes	Yes	9	7
209	3x51	3x55	Shared	18.51	13.14	No	No	No	No	7	7
210	3x51	5x60	Shared	3.37	5.61	No	No	No	No	7	4
211	3x53	I2x53	Shared	16.975	25.72	Yes	No	Yes	Yes	8	7
212	3x54	5x65	Shared	4.605	3.07	No	No	No	No	9	8
213	3x56	I2x52	Shared	3.13	6.26	Yes	No	No	No	6	5
214	I2x53	I2x57	Shared	11.355	7.57	Yes	Yes	No	No	7	7
215	4x38	4x39	Shared	4.375	5.25	No	No	No	No	8	3
216	4x52	5x461	Shared	6.265	6.83	No	No	Yes	Yes	4	8
217	4x56	5x461	Shared	15.325	13.48	No	No	Yes	Yes	5	8
218	4x59	4x60	Shared	3.5	3.5	No	No	No	Yes	6	4
219	4x59	5x39	Shared	6.245	3.75	No	No	Yes	Yes	6	6
220	4x60	E2.I175	Shared	3.39	5.08	No	Yes	Yes	No	4	3
221	4x60	5x39	Shared	13.215	12.52	No	Yes	Yes	Yes	4	6
222	5x39	E2.W146	Shared	12.54	7.72	Yes	Yes	No	Yes	6	6
223	5x42	E2.W146	Shared	6.515	5.01	No	Yes	No	Yes	5	6
224	E2.L149	E2.N147	Shared	4.805	4.12	No	No	Yes	Yes	4	6
225	5x36	E2.N148	Shared	4.47	2.98	No	No	No	No	5	4
226	E2.E153	E2.L149	Shared	7.29	7.95	No	No	No	No	2	4
227	E2.P165	E2.V152	Shared	4.415	3.53	Yes	No	No	No	5	1
228	E2.S161	E2.W156	Shared	17.915	14.83	No	No	Yes	No	6	1
229	E2.P165	E2.W156	Shared	8.11	12.16	Yes	No	Yes	No	5	1
230	E2.V166	E2.W156	Shared	3.065	3.68	No	No	Yes	No	3	1
231	E2.E164	E2.P165	Shared	4.715	3.14	No	No	Yes	No	3	5
232	E2.I175	E2x52	Shared	10.675	11.3	Yes	No	No	Yes	3	4
233	E2x52	Lig	Shared	41.68	20.06	No	Yes	Yes	Yes	4	0
234	E2.E172	Lig	Shared	7.49	7.86	No	No	Yes	Yes	4	0
235	5x36	5x38	Shared	5.75	7.19	No	No	No	No	5	3
236	5x37	6x55	Shared	5.61	4.21	No	No	No	No	3	5
237	5x37	6x59	Shared	3.535	2.83	No	No	Yes	Yes	3	4
238	5x39	5x40	Shared	5.385	4.79	Yes	Yes	Yes	No	6	5
239	5x39	5x42	Shared	7.22	4.13	Yes	Yes	No	Yes	6	5
240	5x40	5x43	Shared	7.01	7.01	Yes	No	No	No	5	5
241	5x41	6x59	Shared	5.215	5.96	No	No	Yes	Yes	4	4
242	5x411	6x59	Shared	4.69	4.69	No	No	Yes	Yes	4	4
243	5x42	5x461	Shared	12.025	9.02	No	Yes	Yes	Yes	5	8
244	5x44	5x45	Shared	6.43	7.5	Yes	Yes	No	No	5	4
245	5x44	5x47	Shared	6.555	3.93	Yes	Yes	No	No	5	5
246	5x44	5x48	Shared	9.745	4.87	Yes	Yes	No	No	5	5
247	5x44	6x52	Shared	23.76	15.84	Yes	Yes	No	No	5	7
248	5x46	5x461	Shared	10.42	8.58	No	No	Yes	Yes	5	8
249	5x47	6x52	Shared	6.92	12.45	No	No	No	No	5	7
250	5x49	5x50	Shared	5.84	5.84	No	No	No	No	4	8
251	5x54	6x41	Shared	4.34	2.83	No	No	No	No	8	8
252	5x58	6x37	Shared	4.93	8.21	No	Yes	No	No	9	8
253	5x62	5x66	Shared	4.275	3.21	Yes	No	No	No	6	5
254	5x62	6x34	Shared	4.16	2.77	Yes	No	No	No	6	7
255	6x36	7x56	Shared	11.86	10.54	No	No	Yes	No	8	7
256	6x39	6x43	Shared	3.46	5.54	No	No	No	No	6	6
257	6x42	6x46	Shared	5.48	8.53	No	No	No	No	5	6
258	6x44	6x48	Shared	16.54	11.02	Yes	No	Yes	Yes	9	8
259	6x47	7x45	Shared	9.685	7.45	No	No	Yes	No	8	9
260	6x47	7x48	Shared	3.07	1.53	No	No	No	No	8	6
261	6x48	7x41	Shared	11.775	6.06	Yes	Yes	No	No	8	7
262	6x48	7x45	Shared	3.955	6.78	Yes	Yes	Yes	No	8	9
263	6x51	Lig	Shared	18.01	10.94	No	Yes	Yes	Yes	6	0
264	6x55	Lig	Shared	15.255	9.05	No	No	Yes	Yes	5	0
265	6x59	6x60	Shared	6.7	3.65	Yes	Yes	No	No	4	4
266	6x61	E3.C263	Shared	7.28	7.28	No	No	No	No	4	2
267	7x31	7x35	Shared	3.815	5.09	No	No	Yes	Yes	3	3
268	7x38	7x42	Shared	5.305	3.98	No	Yes	Yes	Yes	5	7
269	7x38	Lig	Shared	8.84	6.58	No	Yes	Yes	Yes	5	0
270	4x38	4x40	Shared	9.055	1.29	No	No	No	No	8	5
271	6x58	E3.K265	Shared	4.505	7.51	No	No	No	Yes	4	3
272	7x45	7x49	Shared	3.405	10.9	Yes	No	Yes	Yes	9	9
273	3x54	5x64	Shared	2.98	5.96	No	No	No	No	9	5
274	6x43	7x48	Shared	2.83	7.07	No	No	No	No	6	6
275	8x49	I1x50	Shared	2.82	4.23	No	No	Yes	No	6	8
276	1x37	1x40	Shared	2.76	1.84	No	No	No	No	5	4
277	1x42	7x43	Shared	2.645	1.76	No	No	No	No	7	5
278	4x48	4x51	Shared	2.645	3.53	No	No	No	No	1	4
279	3x23	3x27	Shared	2.63	5.25	Yes	No	No	No	1	4
280	4x38	4x41	Shared	2.585	5.17	No	No	No	No	8	5
281	1x46	7x47	Shared	2.565	3.42	No	No	No	No	8	6
282	7x30	7x33	Shared	2.46	9.85	No	No	No	No	4	4
283	5x51	6x45	Shared	2.365	1.58	No	No	No	No	6	6
284	6x51	7x37	Shared	2.365	3.15	No	Yes	No	No	6	5
285	1x60	I1x49	Shared	2.345	4.69	No	No	No	No	6	6
286	3x52	I2x53	Shared	2.34	2.34	No	No	Yes	Yes	5	7
287	E2.I175	E2.V174	Shared	2.305	3.07	Yes	No	No	Yes	3	3
288	1x50	2x51	Shared	2.22	2.96	Yes	No	No	No	9	7
289	6x53	6x57	Shared	2.205	1.47	No	No	No	No	6	4
290	1x60	8x53	Shared	2.195	4.39	No	No	No	No	6	6
291	1x31	7x32	Shared	1.885	8.79	No	No	No	No	4	1
292	3x30	3x31	Shared	1.88	3.77	No	No	No	No	6	4
293	6x61	E3.P261	Shared	1.88	1.88	No	No	No	No	4	4
294	3x34	4x57	Shared	1.76	5.29	No	Yes	No	No	5	6
295	I1x48	I1x51	Shared	1.75	2.34	No	No	No	No	6	7
296	E2.G163	E2.M162	Shared	1.75	1.75	No	No	No	No	4	4
297	E1x50	E1x52	Shared	1.75	3.5	No	No	No	No	3	7
298	2x49	3x38	Shared	1.71	3.42	No	No	No	No	8	7
299	3x56	I2x50	Shared	1.69	1.69	Yes	No	No	No	6	8
300	7x30	E3.K265	Shared	1.67	1.67	No	No	No	Yes	4	3
301	2x46	3x42	Shared	1.58	3.15	No	Yes	No	No	9	8
302	3x48	5x57	Shared	1.54	3.07	No	No	No	No	6	6
303	1x40	1x44	Shared	1.49	1.49	No	No	No	No	4	5
304	2x61	2x65	Shared	1.47	1.47	No	No	No	No	6	4
305	2x60	7x42	Shared	1.465	4.39	No	No	Yes	Yes	7	7
306	I2x52	I2x55	Shared	1.24	2.48	No	No	No	No	5	5
307	7x55	8x51	Shared	1.07	7.48	No	No	No	No	6	8
308	4x63	E2.N147	Shared	0.85	3.39	No	No	Yes	Yes	5	6
309	6x25	6x26	Shared	0.8	9.55	No	No	No	No	3	3
310	E2.A151	E2.N148	Shared	0.78	3.13	No	No	No	No	3	4
311	5x55	6x41	Shared	0.745	4.47	No	No	No	No	5	8
312	7x32	7x36	Shared	0.735	4.42	No	No	No	No	1	3
313	2x42	4x45	Shared	0.695	1.39	Yes	Yes	No	No	8	5
314	6x42	6x43	Shared	0.61	2.44	No	No	No	No	5	6
315	8x51	8x55	Shared	0.605	2.43	No	No	No	No	8	5
316	I2x53	I2x54	Shared	0.595	8.36	Yes	Yes	No	No	7	4
317	1x29	1x32	a1_on	0	8.66	No	No	No	Yes	6	4
318	1x32	7x35	a1_on	0	6.76	No	Yes	Yes	Yes	4	3
319	1x35	1x36	a1_on	0	3.63	Yes	Yes	No	No	5	5
320	1x35	7x38	a1_on	0	8.46	Yes	Yes	No	Yes	5	5
321	1x39	2x61	a1_on	0	4.1	No	Yes	No	No	6	6
322	1x42	7x39	a1_on	0	3.77	No	No	No	Yes	7	5
323	1x47	2x51	a1_on	0	3.21	No	No	No	No	6	7
324	1x53	8x50	a1_on	0	7.87	No	No	Yes	Yes	9	9
325	1x54	2x44	a1_on	0	4.61	No	No	No	No	7	5
326	2x37	2x39	a1_on	0	4.34	No	No	No	No	7	8
327	2x37	I2x54	a1_on	0	4.15	No	No	No	No	7	4
328	2x39	3x53	a1_on	0	6.47	No	No	Yes	No	8	8
329	2x40	8x47	a1_on	0	6.28	No	Yes	No	No	8	8
330	2x40	8x50	a1_on	0	4.29	No	Yes	Yes	Yes	8	9
331	2x41	4x42	a1_on	0	3.61	No	No	No	No	4	7
332	2x42	3x49	a1_on	0	7.17	Yes	Yes	No	No	8	9
333	2x46	3x43	a1_on	0	5.54	No	Yes	No	No	9	8
334	2x46	7x49	a1_on	0	10.98	No	Yes	Yes	Yes	9	9
335	2x50	3x39	a1_on	0	5.89	Yes	Yes	No	No	9	9
336	2x53	2x54	a1_on	0	3.68	No	No	No	No	8	7
337	2x551	3x35	a1_on	0	5.54	No	No	No	No	5	7
338	2x56	3x35	a1_on	0	4.47	No	No	No	No	6	7
339	2x59	3x31	a1_on	0	3.28	No	No	No	No	5	4
340	2x62	3x28	a1_on	0	5.96	No	No	No	No	4	6
341	2x64	7x35	a1_on	0	6.98	No	No	Yes	Yes	3	3
342	2x66	E2.K168	a1_on	0	3.49	No	No	No	No	3	3
343	3x25	3x28	a1_on	0	3.42	No	No	No	No	9	6
344	3x33	4x60	a1_on	0	3.28	No	Yes	No	Yes	4	4
345	3x33	E2x52	a1_on	0	4.87	No	Yes	No	Yes	4	4
346	3x33	Lig	a1_on	0	3.65	No	Yes	Yes	Yes	4	0
347	3x34	4x53	a1_on	0	3.1	No	Yes	No	No	5	8
348	3x36	Lig	a1_on	0	11.66	No	No	Yes	Yes	6	0
349	3x40	5x47	a1_on	0	4.61	No	Yes	No	No	8	5
350	3x40	6x48	a1_on	0	18.79	No	Yes	Yes	Yes	8	8
351	3x43	7x49	a1_on	0	6.87	No	No	Yes	Yes	8	9
352	3x43	7x53	a1_on	0	4.69	No	No	Yes	Yes	8	9
353	3x44	5x50	a1_on	0	3.28	No	No	No	No	7	8
354	3x46	3x50	a1_on	0	6.26	No	No	Yes	No	9	9
355	3x46	7x53	a1_on	0	6.04	No	No	Yes	Yes	9	9
356	3x50	5x58	a1_on	0	4.12	Yes	No	No	Yes	9	9
357	3x50	7x53	a1_on	0	8.23	Yes	No	Yes	Yes	9	9
358	3x52	3x56	a1_on	0	4.28	No	No	Yes	No	5	6
359	4x56	5x42	a1_on	0	5.24	No	No	No	Yes	5	5
360	4x59	E2.W146	a1_on	0	4.85	No	No	No	Yes	6	6
361	5x38	E2.W146	a1_on	0	3.27	No	No	No	Yes	3	6
362	E2.V174	E2x50	a1_on	0	3.42	No	Yes	No	No	3	9
363	5x37	5x40	a1_on	0	4.33	No	No	Yes	No	3	5
364	5x41	5x411	a1_on	0	3.79	No	No	No	No	4	4
365	5x411	6x60	a1_on	0	7.22	No	No	No	No	4	4
366	5x51	6x44	a1_on	0	7.31	No	No	Yes	No	6	9
367	5x51	6x49	a1_on	0	4.15	No	No	No	No	6	7
368	5x58	6x40	a1_on	0	7.25	No	Yes	No	No	9	8
369	5x58	6x41	a1_on	0	8.21	No	Yes	No	No	9	8
370	5x61	5x65	a1_on	0	3.07	No	No	No	No	9	8
371	5x62	6x30	a1_on	0	5.83	Yes	No	No	No	6	6
372	5x63	5x66	a1_on	0	6.17	No	No	No	No	4	5
373	5x65	6x33	a1_on	0	4.42	No	No	No	No	8	7
374	5x66	5x70	a1_on	0	6.03	No	No	No	No	5	0
375	5x68	5x71	a1_on	0	6.78	No	No	No	No	7	0
376	6x27	6x31	a1_on	0	4.69	No	No	No	No	1	5
377	6x29	6x32	a1_on	0	4.31	No	No	No	No	6	7
378	6x40	7x53	a1_on	0	3.63	No	No	Yes	Yes	8	9
379	6x47	6x48	a1_on	0	3.71	No	No	Yes	Yes	8	8
380	6x48	6x52	a1_on	0	3.17	Yes	Yes	No	No	8	7
381	6x51	7x38	a1_on	0	4.28	No	Yes	No	Yes	6	5
382	6x51	7x41	a1_on	0	7.37	No	Yes	No	No	6	7
383	6x54	E3.K265	a1_on	0	4.23	No	No	No	Yes	4	3
384	7x34	E3.K265	a1_on	0	4.5	No	No	No	Yes	4	3
385	7x36	7x39	a1_on	0	7.54	No	No	No	Yes	3	5
386	7x39	7x40	a1_on	0	3.65	No	Yes	No	No	5	7
387	7x42	Lig	a1_on	0	6.78	Yes	Yes	Yes	Yes	7	0
388	7x54	8x50	a1_on	0	8.32	No	No	Yes	Yes	7	9
389	8x48	8x51	a1_on	0	10.51	No	No	No	No	4	8
390	I2x55	I2x56	a1_on	0	3.04	No	No	No	No	5	4
391	E2.I167	E2.K173	a1_on	0	2.91	No	No	No	No	4	3
392	8x48	8x52	a1_on	0	2.87	No	No	No	No	4	4
393	3x34	4x58	a1_on	0	2.85	No	Yes	No	No	5	4
394	6x54	6x57	a1_on	0	2.85	No	No	No	No	4	4
395	3x55	5x64	a1_on	0	2.82	No	No	No	No	7	5
396	5x64	5x67	a1_on	0	2.82	No	No	No	No	5	4
397	6x31	6x35	a1_on	0	2.82	No	No	No	No	5	7
398	6x56	6x60	a1_on	0	2.79	No	No	No	No	5	4
399	1x56	8x50	a1_on	0	2.77	No	No	Yes	Yes	8	9
400	2x42	4x42	a1_on	0	2.77	Yes	Yes	No	No	8	7
401	3x29	E2x52	a1_on	0	2.77	No	No	No	Yes	4	4
402	3x44	5x53	a1_on	0	2.77	No	No	No	No	7	6
403	5x48	5x52	a1_on	0	2.77	No	No	No	No	5	3
404	1x32	NT.I5	a1_on	0	2.74	No	Yes	No	No	4	0
405	3x23	3x26	a1_on	0	2.57	Yes	No	No	No	1	5
406	E2.E172	E2x51	a1_on	0	2.54	No	No	No	No	4	4
407	5x58	5x61	a1_on	0	2.52	No	Yes	No	No	9	9
408	7x52	7x53	a1_on	0	2.52	No	No	Yes	Yes	8	9
409	2x40	2x43	a1_on	0	2.51	No	Yes	No	No	8	8
410	2x63	E2x52	a1_on	0	2.51	No	No	No	Yes	3	4
411	3x22	E2.I167	a1_on	0	2.51	Yes	Yes	No	No	3	4
412	8x54	8x55	a1_on	0	2.44	No	No	No	No	7	5
413	3x51	3x52	a1_on	0	2.34	No	No	No	No	7	5
414	1x39	7x39	a1_on	0	2.33	No	Yes	No	Yes	6	5
415	1x55	1x58	a1_on	0	2.32	Yes	No	No	No	4	3
416	1x52	1x55	a1_on	0	2.28	No	No	Yes	No	7	4
417	6x27	6x30	a1_on	0	2.24	No	No	No	No	1	6
418	1x48	1x49	a1_on	0	2.03	No	No	No	No	4	8
419	1x36	1x37	a1_on	0	1.76	No	No	No	No	5	5
420	1x49	1x52	a1_on	0	1.71	No	No	No	No	8	7
421	2x38	I2x57	a1_on	0	1.7	No	No	No	No	6	7
422	6x49	6x50	a1_on	0	1.64	No	No	No	No	7	9
423	6x50	7x40	a1_on	0	1.64	No	No	No	No	9	7
424	E2.A157	E2.M162	a1_on	0	1.61	No	No	No	No	1	4
425	4x55	4x56	a1_on	0	1.6	No	No	No	No	4	5
426	2x55	2x551	a1_on	0	1.58	No	No	No	No	4	5
427	6x45	6x49	a1_on	0	1.58	No	No	No	No	6	7
428	6x54	7x37	a1_on	0	1.58	No	No	No	No	4	5
429	7x51	7x52	a1_on	0	1.54	No	No	No	No	7	8
430	2x65	NT.I5	a1_on	0	1.47	No	No	No	No	4	0
431	1x38	1x41	a1_on	0	1.43	No	No	No	No	5	5
432	1x41	1x42	a1_on	0	1.43	No	No	No	No	5	7
433	5x69	6x33	a1_on	0	1.43	No	No	No	No	4	7
434	1x30	1x31	a1_on	0	1.39	No	No	No	No	5	4
435	E3.H264	E3.S262	a1_on	0	1.39	No	No	No	No	2	3
436	5x69	5x70	a1_on	0	1.37	No	No	No	No	4	0
437	E2.R154	E2.S150	a1_on	0	1.32	No	No	No	No	2	2
438	1x57	I1x51	a1_on	0	1.31	No	No	No	No	8	7
439	6x39	7x56	a1_on	0	1.21	No	No	Yes	No	6	7

Orange: nodes, hubs and links specific of a1_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of a1_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	a1_off Avg Int. Strength	a1_on Avg Int. Strength	a1_off Num Of Links	a1_on Num Of Links	ConSurf
1	1x50	a1_off	7.78375	7.03	4	3	9
2	1x55	a1_off	5.9225	3.57667	4	3	4
3	I1x50	a1_off	6.90875	9.79	4	3	8
4	3x23	a1_off	6.8725	3.91	4	2	1
5	3x50	a1_off	10.17	6.20333	4	3	9
6	3x53	a1_off	12.585	16.095	4	2	8
7	3x56	a1_off	2.2875	4.07667	4	3	6
8	E2.W156	a1_off	7.44875	10.2233	4	3	1
9	E2.P165	a1_off	5.095	6.27667	4	3	5
10	E2.I175	a1_off	4.905	6.48333	4	3	3
11	5x40	a1_off	5.026	5.37667	5	3	5
12	5x62	a1_off	3.225	3.93667	5	3	6
13	6x44	a1_off	7.92	8.20333	5	3	9
14	7x45	a1_off	5.579	8.37667	5	3	9
15	7x56	a1_off	5.04875	5.875	4	2	7
16	1x35	Shared	8.183	8.598	5	5	5
17	2x42	Shared	4.76375	3.574	4	5	8
18	2x50	Shared	7.76875	6.92	4	5	9
19	2x57	Shared	4.855	5.7725	6	4	6
20	3x22	Shared	6.967	4.39	5	6	3
21	3x37	Shared	5.396	5.6675	5	4	6
22	I2x53	Shared	8.092	9.948	5	5	7
23	E2.N147	Shared	4.7925	4.8025	4	4	6
24	5x39	Shared	7.95786	6.46167	7	6	6
25	5x44	Shared	9.786	8.035	5	4	5
26	5x461	Shared	10.012	9.116	5	5	8
27	6x48	Shared	9.376	7.59571	5	7	8
28	6x59	Shared	5.035	4.2825	4	4	4
29	7x35	Shared	5.195	6.1975	4	4	3
30	7x42	Shared	4.80083	6.37333	6	6	7
31	7x49	Shared	4.31	9.88	4	4	9
32	7x53	Shared	5.676	5.022	5	5	9
33	8x50	Shared	4.918	5.8125	5	4	9
34	Lig	Shared	10.6658	9.27222	12	9	0
35	1x32	a1_on	10.56	6.52	1	4	4
36	1x39	a1_on	11.4983	8.98	3	5	6
37	2x40	a1_on	6.55	7.704	3	5	8
38	2x46	a1_on	2.825	6.615	2	4	9
39	3x33	a1_on	4.13333	4.415	3	4	4
40	3x34	a1_on	5.59	5.95	2	4	5
41	3x40	a1_on	4.61333	7.438	3	5	8
42	4x60	a1_on	6.70167	6.095	3	4	4
43	E2.W146	a1_on	8.205	5.2125	3	4	6
44	E2x52	a1_on	26.1775	8.302	2	5	4
45	E2.V174	a1_on	5.8	4.54	3	4	3
46	5x42	a1_on	8.58667	5.85	3	4	5
47	5x58	a1_on	4.535	5.71833	3	6	9
48	6x51	a1_on	10.1875	6.435	2	4	6
49	E3.K265	a1_on	3.27	4.4775	3	4	3
50	7x38	a1_on	7.0725	5.825	2	4	5
51	7x39	a1_on	7.715	5.97	2	5	5

Orange: nodes, hubs and links specific of a1_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of a1_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	a1_off Recurrence	a1_on Recurrence	a1_off Hub1?	a1_on Hub1?	a1_off Hub2?	a1_on Hub2?	ConSurf1	ConSurf2
1	1x35	2x64	a1_off	14.9911	9.04602	Yes	Yes	No	No	5	3
2	1x35	Lig	a1_off	25.9023	0	Yes	Yes	Yes	Yes	5	0
3	1x36	2x64	a1_off	11.9298	0	No	No	No	No	5	3
4	6x48	Lig	a1_off	100	0	Yes	Yes	Yes	Yes	8	0
5	7x49	7x53	a1_off	91.5467	0	Yes	Yes	Yes	Yes	9	9
6	1x53	7x53	a1_off	12.1623	0	No	No	Yes	Yes	9	9
7	7x53	8x50	a1_off	89.6645	0	Yes	Yes	Yes	Yes	9	9
8	8x50	8x54	a1_off	16.6187	0	Yes	Yes	No	No	9	7
9	1x52	8x57	a1_off	12.1236	0	No	No	No	No	7	7
10	1x55	8x57	a1_off	10.6676	0	Yes	No	No	No	4	7
11	6x32	8x50	a1_off	81.1559	0	No	No	Yes	Yes	7	9
12	6x32	8x48	a1_off	80.4694	0	No	No	No	No	7	4
13	8x48	8x49	a1_off	79.7221	0	No	No	No	No	4	6
14	8x49	I1x50	a1_off	44.7077	2.04265	No	No	Yes	No	6	8
15	2x37	3x53	a1_off	29.7221	0	No	No	Yes	No	7	8
16	3x53	I2x53	a1_off	11.3209	0.471381	Yes	No	Yes	Yes	8	7
17	6x44	6x48	a1_off	23.5496	6.50393	Yes	No	Yes	Yes	9	8
18	3x39	6x44	a1_off	22.2044	0	No	No	Yes	No	9	9
19	2x49	3x39	a1_off	20.8592	0	No	No	No	No	8	9
20	2x49	3x38	a1_off	19.8849	1.73401	No	No	No	No	8	7
21	3x38	4x50	a1_off	30.0985	1.73401	No	No	No	No	7	9
22	2x45	4x50	a1_off	28.9194	0	No	No	No	No	9	9
23	2x45	4x46	a1_off	27.9063	1.93042	No	No	No	No	9	8
24	2x42	4x46	a1_off	25.8691	3.85522	Yes	Yes	No	No	8	8
25	2x42	3x46	a1_off	22.9628	0	Yes	Yes	No	No	8	9
26	3x25	E2.V174	a1_off	28.0558	5.47699	No	No	No	Yes	9	3
27	3x25	E2x50	a1_off	25.2657	0.0112233	No	No	No	No	9	9
28	E1x52	E2x50	a1_off	17.3494	0	No	No	No	No	7	9
29	3x24	E1x52	a1_off	12.7823	7.76094	No	No	No	No	5	7
30	3x23	3x27	a1_off	13.7677	9.73064	Yes	No	No	No	1	4
31	3x27	4x61	a1_off	10.341	7.80584	No	No	No	No	4	5
32	5x40	Lig	a1_off	20.5768	0	Yes	No	Yes	Yes	5	0
33	5x39	5x40	a1_off	13.5352	5.79125	Yes	Yes	Yes	No	6	5
34	3x40	6x44	a1_off	12.2232	2.10438	No	Yes	Yes	No	8	9
35	5x39	5x42	a1_off	13.3415	6.83502	Yes	Yes	No	Yes	6	5
36	3x46	6x37	a1_off	21.9663	0	No	No	No	No	9	8
37	5x58	6x37	a1_off	21.4294	3.56341	No	Yes	No	No	9	8
38	3x53	6x30	a1_off	13.0204	0	Yes	No	No	No	8	6
39	7x56	8x49	a1_off	51.6995	0	Yes	No	No	No	7	6
40	6x35	7x56	a1_off	43.5396	0	No	No	Yes	No	7	7
41	5x62	6x35	a1_off	42.4601	0	Yes	No	No	No	6	7
42	5x62	6x31	a1_off	33.5252	0	Yes	No	No	No	6	5
43	5x65	6x31	a1_off	32.0195	0	No	No	No	No	8	5
44	3x54	5x61	a1_off	27.6406	0	No	No	No	No	9	9
45	3x51	5x61	a1_off	26.0961	0	No	No	No	No	7	9
46	3x51	3x55	a1_off	19.7852	8.92256	No	No	No	No	7	7
47	3x55	3x56	a1_off	18.1798	0	No	No	Yes	No	7	6
48	3x56	I2x52	a1_off	13.2972	5.66779	Yes	No	No	No	6	5
49	4x60	E2.I175	a1_off	13.9061	6.99776	No	Yes	Yes	No	4	3
50	4x60	5x39	a1_off	13.7788	5.7688	No	Yes	Yes	Yes	4	6
51	5x36	E2.W146	a1_off	11.1659	0	No	No	No	Yes	5	6
52	E2.P165	E2.W156	a1_off	13.1311	5.83614	Yes	No	Yes	No	5	1
53	6x58	Lig	a1_off	30.4694	0	No	No	Yes	Yes	4	0
54	5x37	6x58	a1_off	21.0806	0	No	No	No	No	3	4
55	5x41	6x59	a1_off	30.6632	2.0651	No	No	Yes	Yes	4	4
56	5x41	5x45	a1_off	24.618	0	No	No	No	No	4	4
57	5x44	5x45	a1_off	21.5788	1.72839	Yes	Yes	No	No	5	4
58	5x62	6x38	a1_off	15.8049	0	Yes	No	No	No	6	6
59	6x26	6x30	a1_off	11.736	0	No	No	No	No	3	6
60	2x57	7x42	a1_off	13.7788	6.25701	Yes	Yes	Yes	Yes	6	7
61	6x44	7x45	a1_off	13.1477	0	Yes	No	Yes	No	9	9
62	5x58	6x38	a1_off	14.731	0	No	Yes	No	No	9	6
63	3x38	4x53	a1_off	11.8246	5.17957	No	No	No	No	7	8
64	6x48	7x45	Shared	86.1437	94.5062	Yes	Yes	Yes	No	8	9
65	7x45	7x49	Shared	96.4626	100	Yes	No	Yes	Yes	9	9
66	2x50	7x49	Shared	19.9956	59.1246	Yes	Yes	Yes	Yes	9	9
67	1x50	2x50	Shared	10.4185	94.1526	Yes	No	Yes	Yes	9	9
68	1x52	8x54	Shared	13.5463	13.4961	No	No	No	No	7	7
69	2x40	I1x50	Shared	32.3572	10.1235	No	Yes	Yes	No	8	8
70	2x37	2x40	Shared	31.2334	35.202	No	No	No	Yes	7	8
71	E2x52	Lig	Shared	60.4683	53.0696	No	Yes	Yes	Yes	4	0
72	E2.I175	E2x52	Shared	59.3335	49.1919	Yes	No	No	Yes	3	4
73	E2.I175	E2.V174	Shared	68.2961	54.5174	Yes	No	No	Yes	3	3
74	3x22	E2.V174	Shared	40.5558	46.7228	Yes	Yes	No	Yes	3	3
75	3x22	E2.V152	Shared	31.6597	22.5533	Yes	Yes	No	No	3	1
76	E2.P165	E2.V152	Shared	25.62	20.9147	Yes	No	No	No	5	1
77	E2.E164	E2.P165	Shared	13.2695	13.468	No	No	Yes	No	3	5
78	3x37	4x53	Shared	13.1089	13.5971	Yes	Yes	No	No	6	8
79	5x42	5x461	Shared	16.2533	10.5556	No	Yes	Yes	Yes	5	8
80	3x47	5x58	Shared	21.064	11.257	No	No	No	Yes	9	9
81	3x54	5x65	Shared	30.4971	20.1347	No	No	No	No	9	8
82	6x55	Lig	Shared	21.7006	15.0112	No	No	Yes	Yes	5	0
83	5x37	6x55	Shared	22.0272	13.2772	No	No	No	No	3	5
84	5x37	6x59	Shared	40.1904	10.2637	No	No	Yes	Yes	3	4
85	6x48	7x41	Shared	10.9832	18.2772	Yes	Yes	No	No	8	7
86	3x37	5x461	Shared	14.6756	13.5129	Yes	Yes	Yes	Yes	6	8
87	1x39	7x39	a1_on	0	25.0337	No	Yes	No	Yes	6	5
88	1x35	7x35	a1_on	0.69752	11.5769	Yes	Yes	Yes	Yes	5	3
89	1x35	1x36	a1_on	0	10.303	Yes	Yes	No	No	5	5
90	1x35	7x38	a1_on	0	27.7273	Yes	Yes	No	Yes	5	5
91	1x39	7x42	a1_on	1.64415	37.1324	No	Yes	Yes	Yes	6	7
92	2x56	7x42	a1_on	2.85651	57.4467	No	No	Yes	Yes	6	7
93	2x53	2x56	a1_on	9.25598	57.615	No	No	No	No	8	6
94	2x53	7x46	a1_on	8.27613	58.0976	No	No	No	No	8	9
95	2x50	7x46	a1_on	8.02701	59.4444	Yes	Yes	No	No	9	9
96	1x50	2x51	a1_on	5.45283	31.1841	Yes	No	No	No	9	7
97	1x47	2x51	a1_on	0	29.0123	No	No	No	No	6	7
98	1x47	1x48	a1_on	2.29185	26.8294	No	No	No	No	6	4
99	1x50	7x50	a1_on	3.90833	68.1987	Yes	No	No	No	9	9
100	1x48	1x49	a1_on	0	24.6352	No	No	No	No	4	8
101	1x49	1x52	a1_on	0	22.4299	No	No	No	No	8	7
102	1x53	7x50	a1_on	4.6612	66.4198	No	No	No	No	9	9
103	1x53	2x47	a1_on	6.13928	15.6285	No	No	No	No	9	9
104	1x53	8x50	a1_on	0	51.9641	No	No	Yes	Yes	9	9
105	1x54	2x47	a1_on	5.20926	13.4287	No	No	No	No	7	9
106	2x40	8x50	a1_on	0	47.5309	No	Yes	Yes	Yes	8	9
107	2x37	2x39	a1_on	0	15.6229	No	No	No	No	7	8
108	2x37	I2x54	a1_on	0	18.165	No	No	No	No	7	4
109	2x39	3x49	a1_on	0.182684	12.7497	No	No	No	No	8	9
110	2x42	3x49	a1_on	0	12.8339	Yes	Yes	No	No	8	9
111	2x46	2x50	a1_on	3.33813	20.0281	No	Yes	Yes	Yes	9	9
112	6x51	7x38	a1_on	0	12.0595	No	Yes	No	Yes	6	5
113	6x51	7x41	a1_on	0	18.1818	No	Yes	No	No	6	7
114	7x38	Lig	a1_on	8.38131	13.9001	No	Yes	Yes	Yes	5	0
115	3x36	Lig	a1_on	0	68.5802	No	No	Yes	Yes	6	0
116	3x36	6x48	a1_on	1.69398	68.8664	No	No	Yes	Yes	6	8
117	3x43	7x49	a1_on	0	76.532	No	No	Yes	Yes	8	9
118	3x40	6x48	a1_on	0	30.1852	No	Yes	Yes	Yes	8	8
119	3x37	3x40	a1_on	8.719	24.7475	Yes	Yes	No	Yes	6	8
120	3x22	3x26	a1_on	1.55004	13.3895	Yes	Yes	No	No	3	5
121	3x23	3x26	a1_on	0	11.6442	Yes	No	No	No	1	5
122	3x21	E2.E164	a1_on	2.34721	11.5769	No	No	No	No	6	3
123	3x33	Lig	a1_on	0	19.1863	No	Yes	Yes	Yes	4	0
124	3x33	5x39	a1_on	3.11116	15.4265	No	Yes	Yes	Yes	4	6
125	3x43	7x53	a1_on	0	94.422	No	No	Yes	Yes	8	9
126	3x50	7x53	a1_on	0	44.2031	Yes	No	Yes	Yes	9	9
127	3x50	5x58	a1_on	0	43.0303	Yes	No	No	Yes	9	9
128	6x40	7x53	a1_on	0	44.3603	No	No	Yes	Yes	8	9
129	5x58	6x40	a1_on	0	42.8171	No	Yes	No	No	9	8
130	I2x53	I2x54	a1_on	1.68844	16.9529	Yes	Yes	No	No	7	4
131	3x52	I2x53	a1_on	1.68844	15.0898	No	No	Yes	Yes	5	7
132	5x58	5x61	a1_on	0	60.0337	No	Yes	No	No	9	9
133	5x61	5x65	a1_on	0	56.9416	No	No	No	No	9	8
134	3x54	5x64	a1_on	1.72166	17.3232	No	No	No	No	9	5
135	3x55	5x64	a1_on	0	11.431	No	No	No	No	7	5
136	5x38	E2.W146	a1_on	0	11.257	No	No	No	Yes	3	6
137	5x58	6x41	a1_on	0	11.1785	No	Yes	No	No	9	8
138	5x65	6x33	a1_on	0	38.4736	No	No	No	No	8	7
139	5x69	6x33	a1_on	0	35.275	No	No	No	No	4	7
140	5x69	5x70	a1_on	0	31.8013	No	No	No	No	4	0
141	5x66	5x70	a1_on	0	28.3109	No	No	No	No	5	0
142	5x62	5x66	a1_on	1.72166	21.2963	Yes	No	No	No	6	5
143	5x62	6x30	a1_on	0	14.2368	Yes	No	No	No	6	6
144	6x27	6x30	a1_on	0	10.7015	No	No	No	No	1	6
145	6x47	7x48	a1_on	0.0498229	11.532	No	No	No	No	8	6
146	6x51	7x37	a1_on	3.44885	16.2009	No	Yes	No	No	6	5
147	6x54	7x37	a1_on	0	14.4276	No	No	No	No	4	5
148	8x54	8x55	a1_on	0	11.4703	No	No	No	No	7	5
149	2x46	3x43	a1_on	0	19.3996	No	Yes	No	No	9	8
150	7x42	Lig	a1_on	0	43.5129	Yes	Yes	Yes	Yes	7	0

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
1x32	2x64	Shared	10.56	7.92	0	1	2	2
1x35	1x39	Shared	15.15	17.96	1	1	1	2
1x35	2x64	Shared	10.465	6.98	1	1	1	2
1x35	7x35	Shared	5.96	5.96	1	1	1	1
1x35	7x39	a1_off	4.125	0	1	1	1	2
1x35	Lig	a1_off	5.215	0	1	1	1	0
1x39	2x57	Shared	8.88	8.2	1	1	2	2
1x39	7x42	Shared	10.465	12.31	1	1	2	1
2x56	3x32	a1_off	4.81	0	0	0	2	1
2x56	7x42	Shared	3.46	4.15	0	0	2	1
2x57	7x42	Shared	4.64	6.63	1	1	2	1
3x29	E2.I175	a1_off	3.25	0	0	0	2	2
3x32	Lig	Shared	6.61	6.87	0	0	1	0
3x33	5x39	Shared	6.45	5.86	1	1	1	2
3x33	5x40	a1_off	4.24	0	1	1	1	1
3x36	6x48	Shared	9.785	3.64	0	0	1	1
3x40	6x44	Shared	5.65	6.28	0	2	2	2
4x60	E2.I175	Shared	3.39	5.08	1	1	2	2
4x60	5x39	Shared	13.215	12.52	1	1	2	2
E2.I175	E2x52	Shared	10.675	11.3	0	0	2	1
E2x52	Lig	Shared	41.68	20.06	0	1	1	0
E2.E172	Lig	Shared	7.49	7.86	0	0	1	0
5x37	6x55	Shared	5.61	4.21	0	0	2	1
5x37	6x58	a1_off	4.515	0	0	0	2	1
5x39	5x40	Shared	5.385	4.79	1	1	2	1
5x39	5x43	a1_off	4.65	0	1	1	2	2
5x40	5x43	Shared	7.01	7.01	1	0	1	2
5x40	6x55	a1_off	4.91	0	1	0	1	1
5x40	Lig	a1_off	3.585	0	1	0	1	0
6x44	6x48	Shared	16.54	11.02	1	2	2	1
6x44	7x45	a1_off	6.645	0	1	2	2	2
6x47	7x45	Shared	9.685	7.45	1	2	2	2
6x48	7x41	Shared	11.775	6.06	1	2	1	2
6x48	7x45	Shared	3.955	6.78	1	2	1	2
6x48	Lig	a1_off	4.825	0	1	2	1	0
6x51	Lig	Shared	18.01	10.94	0	1	1	0
6x54	7x34	a1_off	3.685	0	0	0	2	1
6x55	Lig	Shared	15.255	9.05	1	0	1	0
6x58	Lig	a1_off	3.805	0	0	0	1	0
7x31	7x35	Shared	3.815	5.09	0	0	2	1
7x34	Lig	a1_off	3.735	0	0	0	1	0
7x35	Lig	a1_off	8.94	0	1	1	1	0
7x38	7x42	Shared	5.305	3.98	0	1	1	1
7x38	Lig	Shared	8.84	6.58	0	1	1	0
7x41	7x42	a1_off	3.47	0	0	0	2	1
6x58	E3.K265	Shared	4.505	7.51	0	0	1	2
1x36	2x64	a1_off	2.83	0	4	0	2	2
6x51	7x37	Shared	2.365	3.15	0	1	1	2
1x31	7x35	a1_off	2.065	0	0	0	2	1
3x33	4x57	a1_off	1.71	0	1	1	1	2
2x60	7x42	Shared	1.465	4.39	0	0	2	1
1x32	7x35	a1_on	0	6.76	0	1	2	1
1x35	1x36	a1_on	0	3.63	1	1	1	2
1x35	7x38	a1_on	0	8.46	1	1	1	1
2x64	7x35	a1_on	0	6.98	0	1	2	1
3x33	4x60	a1_on	0	3.28	1	1	1	2
3x33	E2x52	a1_on	0	4.87	1	1	1	1
3x33	Lig	a1_on	0	3.65	1	1	1	0
3x36	Lig	a1_on	0	11.66	0	0	1	0
3x40	6x48	a1_on	0	18.79	0	2	2	1
5x37	5x40	a1_on	0	4.33	0	0	2	1
6x47	6x48	a1_on	0	3.71	1	2	2	1
6x48	6x52	a1_on	0	3.17	1	2	1	2
6x51	7x38	a1_on	0	4.28	0	1	1	1
6x51	7x41	a1_on	0	7.37	0	1	1	2
6x54	E3.K265	a1_on	0	4.23	0	0	2	2
7x34	E3.K265	a1_on	0	4.5	0	0	1	2
7x42	Lig	a1_on	0	6.78	1	1	1	0
3x29	E2x52	a1_on	0	2.77	0	0	2	1
E2.E172	E2x51	a1_on	0	2.54	0	0	1	2
2x63	E2x52	a1_on	0	2.51	0	0	2	1
1x39	7x39	a1_on	0	2.33	1	1	2	2
6x54	7x37	a1_on	0	1.58	0	0	2	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	a1_off	5UEN-A₁-DU172 5N2S-A₁-PSB36
	a1_on	7LD4-A₁-Adenosine-Gi2/&β;1/&γ;2

Network Difference
Value	a1_off	a1_on
I_min	3.005	3.07
Number of Linked Nodes	284	269
Number of Specific Nodes	21 (7.39%)	6 (2.23%)
Number of Shared Nodes	263 (92.61%)	263 (97.77%)
Number of Links	316	297
Number of Specific Links	142 (44.94%)	123 (41.41%)
Number of Shared Links	174 (55.06%)	174 (58.59%)
Number of Hubs	34	36
Number of Specific Hubs	15 (44.12%)	17 (47.22%)
Number of Shared Hubs	19 (55.88%)	19 (52.78%)
Average % Shared Neighbours (Jaccard)	42.09
Average % Shared Neighbours (Otsuka)	51.33
Average % Shared Neighbours (Overlap Coefficient)	60.91
Average % Shared Cliques (k3-6)	79.17
Graphlets Similarity	0.573699

Paths Difference
Value	a1_off	a1_on
Number Of Nodes in MetaPath	85	86
Specific Nodes in MetaPath	39 (45.88%)	40 (46.51%)
Shared Nodes in MetaPath	263 (92.61%)	263 (92.61%)
Number Of Links MetaPath	86	87
Specific Links in MetaPath	63 (73.26%)	64 (73.56%)
Shared Links in MetaPath	174 (55.06%)	174 (55.06%)
Number of Shortest Paths	46979	49425
Length Of Smallest Path	3	3
Average Path Length	13.6732	13.6028
Length of Longest Path	37	33
Minimum Path Strength	0.735	1.4
Average Path Strength	5.98656	6.15623
Maximum Path Strength	29.845	17.04
Minimum Path Correlation	0.7	0.7
Average Path Correlation	0.919722	0.92871
Maximum Path Correlation	0.99	0.99
Minimum % Of Corr. Nodes	3.33333	3.84615
Average % Of Corr. Nodes	44.6651	52.2151
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	39.7359	39.7394
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

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