Orange: nodes, hubs and links specific of a1_on_gp network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of a1_off network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.


Index Hub Owner a1_on_gp Avg Int. Strength a1_off Avg Int. Strength a1_on_gp Num Of Links a1_off Num Of Links ConSurf
1g.h1x8 a1_on_gp2.6350407
2g.l1x4 a1_on_gp6.0280508
3g.h2x8 a1_on_gp4.2850407
4g.h2x9 a1_on_gp2.59250404
5g.h2x11 a1_on_gp8.87750406
6g.ctx3 a1_on_gp6.6680509
7g.ctx5 a1_on_gp3.63250409
8g.ctx6 a1_on_gp4.65250406
9g.ctx14 a1_on_gp5.56250409
10g.ctx15 a1_on_gp5.360409
11g.ctx16 a1_on_gp4.21250808
121x32 a1_on_gp6.5210.56414
131x39 a1_on_gp8.9811.4983536
141x42 a1_on_gp2.4752.84167437
152x39 a1_on_gp5.51758.7875428
162x40 a1_on_gp6.851676.55638
172x46 a1_on_gp5.8622.825529
183x33 a1_on_gp4.0984.13333534
193x34 a1_on_gp5.955.59425
203x40 a1_on_gp7.4384.61333538
213x51 a1_on_gp5.90258.345437
224x56 a1_on_gp5.797510.885425
234x60 a1_on_gp6.0956.70167434
24E2.W146 a1_on_gp5.21258.205436
25E2x52 a1_on_gp8.3126.1775524
26E2.V174 a1_on_gp4.545.8433
275x41 a1_on_gp3.74755.25833434
285x42 a1_on_gp5.858.58667435
295x58 a1_on_gp5.718334.535639
305x65 a1_on_gp4.4254.8428
316x51 a1_on_gp6.4410.1875426
326x60 a1_on_gp4.076.7414
33E3.K265 a1_on_gp4.47753.27433
347x38 a1_on_gp5.837.0725425
357x39 a1_on_gp5.977.715525
36G.S1.02 a1_on_gp5.90250405
37G.S1.05 a1_on_gp7.370409
38G.S1.07 a1_on_gp5.3350409
39G.H1.01 a1_on_gp4.230509
40G.H1.04 a1_on_gp2.9380507
41G.S2.01 a1_on_gp4.9640508
42G.S2.08 a1_on_gp7.6150405
43G.S3.03 a1_on_gp8.0880507
44G.S3.05 a1_on_gp5.52750407
45G.S3.06 a1_on_gp6.166670606
46G.S3.08 a1_on_gp5.080409
47G.s3h2.03 a1_on_gp3.98250409
48G.H2.06 a1_on_gp4.8550609
49G.H2.07 a1_on_gp4.303330609
50G.H2.09 a1_on_gp6.090408
51G.H2.10 a1_on_gp3.43250407
52G.h2s4.01 a1_on_gp4.891250809
53G.S4.02 a1_on_gp3.8960507
54G.S4.04 a1_on_gp6.9150409
55G.s4h3.04 a1_on_gp7.040608
56G.H3.02 a1_on_gp3.73250408
57G.H3.09 a1_on_gp6.4240509
58G.H3.12 a1_on_gp3.7950408
59G.H3.13 a1_on_gp4.080506
60G.H3.17 a1_on_gp7.371670605
61G.H3.18 a1_on_gp5.2850409
62G.S5.02 a1_on_gp3.9980506
63G.S5.03 a1_on_gp3.1440508
64G.S5.05 a1_on_gp3.321430709
65G.S5.06 a1_on_gp5.4040509
66G.s5hg.01 a1_on_gp3.9860509
67G.HG.04 a1_on_gp5.5080508
68G.HG.08 a1_on_gp4.17250406
69G.HG.15 a1_on_gp4.8540507
70G.hgh4.01 a1_on_gp5.7720505
71G.hgh4.02 a1_on_gp5.497140708
72G.hgh4.04 a1_on_gp4.64750405
73G.hgh4.05 a1_on_gp7.7020506
74G.H4.10 a1_on_gp8.89250406
75G.H4.11 a1_on_gp3.353330607
76G.H4.15 a1_on_gp5.6480508
77G.h4s6.02 a1_on_gp4.690407
78G.h4s6.11 a1_on_gp5.1980507
79G.S6.01 a1_on_gp3.730406
80G.S6.02 a1_on_gp7.270408
81G.S6.05 a1_on_gp4.6150405
82G.s6h5.01 a1_on_gp5.7220509
83G.H5.03 a1_on_gp6.2880508
84G.H5.06 a1_on_gp7.030403
85G.H5.08 a1_on_gp6.35750408
86G.H5.17 a1_on_gp5.9050405
87G.H5.23 a1_on_gp5.560404
88G.H5.26 a1_on_gp8.34750407
89b.1x15 a1_on_gp4.6250407
90b.1x19 a1_on_gp5.6480506
91b.h2x4 a1_on_gp2.74250403
92b.h2x5 a1_on_gp3.71250405
93b.lhb1x11 a1_on_gp3.4480504
94b.b1x4 a1_on_gp3.770407
95b.b1x6 a1_on_gp8.590409
96b.l1x3 a1_on_gp7.940709
97b.b2x1 a1_on_gp8.2160508
98b.b2x3 a1_on_gp4.88750406
99b.b2x5 a1_on_gp6.021430707
100b.b3x2 a1_on_gp6.090405
101b.b3x3 a1_on_gp3.890408
102b.l3x2 a1_on_gp6.3940509
103b.b4x3 a1_on_gp4.4240507
104b.b4x4 a1_on_gp8.920408
105b.b4x5 a1_on_gp4.380607
106b.b4x6 a1_on_gp8.437140709
107b.l4x2 a1_on_gp7.520404
108b.b5x2 a1_on_gp6.3050407
109b.b5x3 a1_on_gp4.476670609
110b.b5x5 a1_on_gp5.90405
111b.b5x7 a1_on_gp6.530407
112b.l5x1 a1_on_gp4.130508
113b.l5x5 a1_on_gp6.536250809
114b.b6x5 a1_on_gp4.922860706
115b.l6x5 a1_on_gp4.760404
116b.b7x1 a1_on_gp5.170504
117b.b7x2 a1_on_gp4.130408
118b.b7x4 a1_on_gp4.640408
119b.l7x2 a1_on_gp3.3980509
120b.b8x3 a1_on_gp3.137140706
121b.b8x4 a1_on_gp4.558330606
122b.l8x1 a1_on_gp4.4920505
123b.l8x5 a1_on_gp6.13750404
124b.b9x3 a1_on_gp5.49750406
125b.l9x3 a1_on_gp70709
126b.l9x6 a1_on_gp4.758750808
127b.l9x7 a1_on_gp3.60407
128b.b10x2 a1_on_gp3.54250406
129b.b10x5 a1_on_gp4.007140709
130b.l10x1 a1_on_gp4.160403
131b.b11x1 a1_on_gp5.6350405
132b.b11x2 a1_on_gp4.3180507
133b.b11x4 a1_on_gp5.7220509
134b.b11x5 a1_on_gp4.040406
135b.l11x2 a1_on_gp6.9040509
136b.b12x2 a1_on_gp4.06250407
137b.b12x3 a1_on_gp3.8850408
138b.b12x6 a1_on_gp10.2760508
139b.l12x1 a1_on_gp3.4650406
140b.l12x3 a1_on_gp3.670405
141b.b13x7 a1_on_gp7.6180507
142b.l13x3 a1_on_gp7.211430709
143b.l13x6 a1_on_gp5.2150409
144b.l13x7 a1_on_gp5.08750409
145b.b14x1 a1_on_gp3.710408
146b.b15x1 a1_on_gp8.6750409
147b.b15x2 a1_on_gp5.0920506
148b.b15x3 a1_on_gp5.26250409
149b.l15x1 a1_on_gp7.470407
150b.l15x2 a1_on_gp6.5720509
151b.b16x2 a1_on_gp4.1050405
152b.b16x4 a1_on_gp10.480406
153b.b16x5 a1_on_gp4.510405
154b.b16x6 a1_on_gp8.443330608
155b.b17x7 a1_on_gp8.580408
156b.l17x3 a1_on_gp7.501250809
157b.l17x6 a1_on_gp6.86250409
158b.b18x3 a1_on_gp5.090408
159b.b18x5 a1_on_gp4.9080505
160b.l18x1 a1_on_gp6.793750806
161b.l18x2 a1_on_gp6.7250407
162b.l18x3 a1_on_gp7.0260505
163b.b19x2 a1_on_gp6.176670606
164b.b19x4 a1_on_gp5.7840508
165b.l19x2 a1_on_gp8.5680509
166b.b20x2 a1_on_gp5.1940506
167b.b20x4 a1_on_gp10.8220508
168b.b20x6 a1_on_gp7.1640506
169b.b20x7 a1_on_gp4.4660509
170b.l20x2 a1_on_gp6.0250409
171b.b21x1 a1_on_gp10.740407
172b.b21x7 a1_on_gp5.8850605
173b.l21x5 a1_on_gp3.20750404
174b.b22x5 a1_on_gp5.9740507
175b.l22x5 a1_on_gp8.140509
176b.b23x2 a1_on_gp4.49750406
177b.b23x6 a1_on_gp7.666670607
178b.l23x1 a1_on_gp7.9950406
179b.b24x4 a1_on_gp7.186670606
180b.b24x5 a1_on_gp4.11250405
181b.b24x6 a1_on_gp5.8120508
182b.b24x7 a1_on_gp7.09250409
183b.l24x2 a1_on_gp5.7660506
184b.l24x3 a1_on_gp4.84250405
185b.b25x3 a1_on_gp9.39250405
186b.b25x7 a1_on_gp6.1350407
187b.l25x3 a1_on_gp8.5280509
188b.b26x3 a1_on_gp3.030406
189b.l27x1 a1_on_gp10.87570709
190b.l27x2 a1_on_gp7.92250409
191b.b28x2 a1_on_gp6.330404
192b.b28x3 a1_on_gp5.0520507
193b.b28x4 a1_on_gp7.66250406
194b.b28x5 a1_on_gp4.50250405
195b.b28x6 a1_on_gp7.4080509
196b.b28x7 a1_on_gp8.58750409
1971x35 Shared8.5988.183555
1982x42 Shared3.5744.76375548
1992x50 Shared6.927.76875549
2002x57 Shared5.77254.855466
2013x22 Shared4.396.967653
2023x37 Shared5.1085.396556
2033x50 Shared7.437510.17449
2043x53 Shared9.87212.585548
205I2x53 Shared9.9488.092557
206E2.N147 Shared4.80254.7925446
207E2.I175 Shared5.59254.905443
2085x39 Shared6.461677.95786676
2095x40 Shared4.113335.026655
2105x44 Shared8.0359.786455
2115x461 Shared9.11610.012558
2126x48 Shared7.595719.376758
2136x59 Shared4.28255.035444
2147x35 Shared6.19755.195443
2157x42 Shared6.3754.80083667
2167x49 Shared9.884.31449
2177x53 Shared5.0225.676559
2188x50 Shared5.1524.918559
219Lig Shared9.2888910.66589120
2201x50 a1_off7.037.78375349
2211x55 a1_off3.576675.9225344
222I1x50 a1_off9.796.90875348
2233x23 a1_off3.483336.8725341
2243x56 a1_off5.272.2875246
225E2.W156 a1_off10.22337.44875341
226E2.P165 a1_off6.276675.095345
2275x62 a1_off3.936673.225356
2286x44 a1_off8.203337.92359
2297x45 a1_off8.376675.579359
2307x56 a1_off6.025.04875247
   
Orange: nodes, hubs and links specific of a1_on_gp network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of a1_off network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Owner a1_on_gp Recurrence a1_off Recurrence a1_on_gp Hub1? a1_off Hub1? a1_on_gp Hub2? a1_off Hub2? ConSurf1 ConSurf2
1b.1x19 g.h1x14 a1_on_gp12.69710YesNoNoNo69
2b.b17x6 g.h1x14 a1_on_gp13.03640NoNoNoNo79
32x46 2x50 a1_on_gp11.63973.33813YesNoYesYes99
42x46 3x46 a1_on_gp33.5090YesNoNoNo99
53x46 3x50 a1_on_gp33.64090NoNoYesYes99
63x50 5x58 a1_on_gp59.8590YesYesYesNo99
75x58 5x61 a1_on_gp83.0720YesNoNoNo99
85x61 5x65 a1_on_gp94.08760NoNoYesNo98
95x65 G.H5.20 a1_on_gp94.8640YesNoNoNo88
10G.H5.20 G.H5.26 a1_on_gp94.99050NoNoYesNo87
11G.H5.17 G.H5.26 a1_on_gp95.62240YesNoYesNo57
12G.H5.17 G.h4s6.12 a1_on_gp97.63850YesNoNoNo54
13G.S6.02 G.h4s6.12 a1_on_gp98.01510YesNoNoNo84
14G.H5.06 G.S6.02 a1_on_gp65.76920YesNoYesNo38
15G.H5.06 G.S5.03 a1_on_gp32.70170YesNoYesNo38
16G.S4.03 G.S5.03 a1_on_gp65.39630NoNoYesNo88
17G.S1.04 G.S4.03 a1_on_gp99.9130NoNoNoNo78
18G.S1.04 G.S3.03 a1_on_gp99.7580NoNoYesNo77
19G.S2.06 G.S3.03 a1_on_gp99.65060NoNoYesNo87
20G.S2.06 G.S3.05 a1_on_gp99.57510NoNoYesNo87
21G.S1.06 G.S3.05 a1_on_gp99.95350NoNoYesNo97
22G.H1.01 G.S1.06 a1_on_gp99.95840YesNoNoNo99
23G.H1.01 G.s1h1.01 a1_on_gp99.99550YesNoNoNo99
24G.S1.07 G.s1h1.01 a1_on_gp1000YesNoNoNo99
25G.S1.05 G.S1.07 a1_on_gp78.76650YesNoYesNo99
26G.S1.05 G.S3.08 a1_on_gp26.75060YesNoYesNo99
27G.H2.07 G.S3.08 a1_on_gp26.63840YesNoYesNo99
28G.H2.07 G.s3h2.03 a1_on_gp27.47730YesNoYesNo99
29G.s3h2.03 b.l9x6 a1_on_gp27.12270YesNoYesNo98
30b.b10x1 b.l9x6 a1_on_gp27.2160NoNoYesNo98
31b.b10x1 b.b11x5 a1_on_gp26.81290NoNoYesNo96
32b.b11x5 b.l13x7 a1_on_gp25.64530YesNoYesNo69
33b.l13x3 b.l13x7 a1_on_gp17.49140YesNoYesNo99
341x35 7x38 a1_on_gp11.82050YesYesYesNo55
352x46 7x49 a1_on_gp21.60230YesNoYesYes99
363x36 Lig a1_on_gp29.07830NoNoYesYes60
373x36 6x48 a1_on_gp29.4971.69398NoNoYesYes68
383x43 7x49 a1_on_gp43.10350NoNoYesYes89
393x43 7x53 a1_on_gp43.38330NoNoYesYes89
403x50 7x53 a1_on_gp22.15610YesYesYesYes99
416x40 7x53 a1_on_gp22.05420NoNoYesYes89
425x58 6x40 a1_on_gp22.18760YesNoNoNo98
43G.H5.10 G.S6.02 a1_on_gp32.62280NoNoYesNo78
44G.H5.10 G.S5.03 a1_on_gp32.65640NoNoYesNo78
45G.H5.06 G.S5.05 a1_on_gp33.13410YesNoYesNo39
46G.S4.03 G.S5.05 a1_on_gp34.51090NoNoYesNo89
47G.S1.05 G.h2s4.01 a1_on_gp51.96930YesNoYesNo99
48G.H2.07 G.h2s4.01 a1_on_gp26.7660YesNoYesNo99
49G.H2.07 b.l7x2 a1_on_gp27.34910YesNoYesNo99
50b.l7x2 b.l9x6 a1_on_gp41.80450YesNoYesNo98
51G.h2s4.01 b.l5x5 a1_on_gp13.4270YesNoYesNo99
52b.l5x5 b.l7x2 a1_on_gp14.94490YesNoYesNo99
533x51 3x52 a1_on_gp10.63970YesNoNoNo75
543x37 3x40 a1_on_gp11.81848.719YesYesYesNo68
553x40 6x48 a1_on_gp14.34380YesNoYesYes88
56G.H3.18 G.S4.02 a1_on_gp12.29410YesNoYesNo97
57b.l17x6 b.l19x1 a1_on_gp23.72780YesNoNoNo99
58b.l17x5 b.l19x1 a1_on_gp23.28530NoNoNoNo69
59b.b19x6 b.l17x5 a1_on_gp10.75870NoNoNoNo96
60b.b19x6 b.l17x3 a1_on_gp10.54040NoNoYesNo99
61b.l17x5 b.l19x2 a1_on_gp12.3080NoNoYesNo69
62b.l17x3 b.l19x2 a1_on_gp10.54660YesNoYesNo99
63G.H2.06 b.l9x6 a1_on_gp25.03930YesNoYesNo98
64G.H2.06 b.l17x6 a1_on_gp23.92170YesNoYesNo99
65G.H3.15 G.H3.18 a1_on_gp12.060NoNoYesNo89
66b.b26x1 b.l27x1 a1_on_gp17.66530NoNoYesNo99
67b.b26x1 b.b26x2 a1_on_gp17.52440NoNoNoNo97
68b.b26x2 b.b2x3 a1_on_gp17.3860NoNoYesNo76
69b.l11x1 b.l9x6 a1_on_gp16.05980NoNoYesNo98
70b.b11x6 b.l11x1 a1_on_gp15.8340NoNoNoNo99
71b.b2x3 b.b3x2 a1_on_gp10.06140YesNoYesNo65
72G.S1.07 G.S4.02 a1_on_gp14.34430YesNoYesNo97
73G.H3.15 G.H3.17 a1_on_gp12.01210NoNoYesNo85
74G.H2.10 G.h2s4.01 a1_on_gp11.62050YesNoYesNo79
75b.b11x6 b.l9x3 a1_on_gp14.02380NoNoYesNo99
76b.b19x4 b.l17x3 a1_on_gp10.7150YesNoYesNo89
776x48 7x41 Shared10.108110.9832YesYesNoNo87
786x48 7x45 Shared61.425986.1437YesYesNoYes89
797x45 7x49 Shared64.36996.4626NoYesYesYes99
803x51 5x61 Shared11.100226.0961YesNoNoNo79
813x22 E2.V174 Shared11.046240.5558YesYesYesNo33
82E2.I175 E2.V174 Shared13.167668.2961YesYesYesNo33
83E2.I175 E2x52 Shared13.539359.3335YesYesYesNo34
84E2x52 Lig Shared14.806460.4683YesNoYesYes40
851x35 2x64 a1_off3.3809814.9911YesYesNoNo53
861x35 Lig a1_off025.9023YesYesYesYes50
871x36 2x64 a1_off011.9298NoNoNoNo53
886x48 Lig a1_off0100YesYesYesYes80
892x50 7x49 a1_off0.091158519.9956YesYesYesYes99
901x50 2x50 a1_off3.2416810.4185NoYesYesYes99
917x49 7x53 a1_off091.5467YesYesYesYes99
921x53 7x53 a1_off012.1623NoNoYesYes99
937x53 8x50 a1_off089.6645YesYesYesYes99
948x50 8x54 a1_off016.6187YesYesNoNo97
951x52 8x54 a1_off0.8752813.5463NoNoNoNo77
961x52 8x57 a1_off012.1236NoNoNoNo70
971x55 8x57 a1_off010.6676NoYesNoNo40
986x32 8x50 a1_off081.1559NoNoYesYes79
996x32 8x48 a1_off080.4694NoNoNoNo74
1008x48 8x49 a1_off079.7221NoNoNoNo46
1018x49 I1x50 a1_off1.1187444.7077NoNoNoYes68
1022x40 I1x50 a1_off2.2550532.3572YesNoNoYes88
1032x37 2x40 a1_off2.2401531.2334NoNoYesNo78
1042x37 3x53 a1_off029.7221NoNoYesYes78
1053x53 I2x53 a1_off3.6134711.3209YesYesYesYes87
1066x44 6x48 a1_off2.5329723.5496NoYesYesYes98
1073x39 6x44 a1_off022.2044NoNoNoYes99
1082x49 3x39 a1_off020.8592NoNoNoNo89
1092x49 3x38 a1_off0.42632819.8849NoNoNoNo87
1103x38 4x50 a1_off0.42629130.0985NoNoNoNo79
1112x45 4x50 a1_off028.9194NoNoNoNo99
1122x45 4x46 a1_off0.15609827.9063NoNoNoNo98
1132x42 4x46 a1_off0.31217725.8691YesYesNoNo88
1142x42 3x46 a1_off022.9628YesYesNoNo89
1153x25 E2.V174 a1_off1.2757628.0558NoNoYesNo93
1163x25 E2x50 a1_off3.68764e-0525.2657NoNoNoNo99
117E1x52 E2x50 a1_off017.3494NoNoNoNo79
1183x24 E1x52 a1_off1.7010212.7823NoNoNoNo57
1193x22 E2.V152 a1_off5.1013231.6597YesYesNoNo31
120E2.P165 E2.V152 a1_off4.6764125.62NoYesNoNo51
121E2.E164 E2.P165 a1_off2.9764113.2695NoNoNoYes35
1223x23 3x27 a1_off0.42525913.7677NoYesNoNo14
1233x27 4x61 a1_off5.53146e-0510.341NoNoNoNo45
1245x40 Lig a1_off020.5768YesYesYesYes50
1255x39 5x40 a1_off0.025112813.5352YesYesYesYes65
1263x40 6x44 a1_off0.0079837512.2232YesNoNoYes89
1273x37 4x53 a1_off3.4100213.1089YesYesNoNo68
1285x39 5x42 a1_off0.047496813.3415YesYesYesNo65
1295x42 5x461 a1_off2.5531916.2533YesNoYesYes58
1303x46 6x37 a1_off021.9663NoNoNoNo98
1315x58 6x37 a1_off0.15095421.4294YesNoNoNo98
1323x47 5x58 a1_off0.45278721.064NoNoYesNo99
1333x53 6x30 a1_off013.0204YesYesNoNo86
1347x56 8x49 a1_off051.6995NoYesNoNo76
1356x35 7x56 a1_off043.5396NoNoNoYes77
1365x62 6x35 a1_off042.4601NoYesNoNo67
1375x62 6x31 a1_off033.5252NoYesNoNo65
1385x65 6x31 a1_off032.0195YesNoNoNo85
1393x54 5x65 a1_off0.58983830.4971NoNoYesNo98
1403x54 5x61 a1_off027.6406NoNoNoNo99
1413x51 3x55 a1_off0.1766219.7852YesNoNoNo77
1423x55 3x56 a1_off018.1798NoNoNoYes76
1433x56 I2x52 a1_off0.47740213.2972NoYesNoNo65
1444x60 E2.I175 a1_off0.025057513.9061YesNoYesYes43
1454x60 5x39 a1_off0.021074913.7788YesNoYesYes46
1465x36 E2.W146 a1_off011.1659NoNoYesNo56
147E2.P165 E2.W156 a1_off1.2758113.1311NoYesNoYes51
1486x55 Lig a1_off2.1206721.7006NoNoYesYes50
1495x37 6x55 a1_off0.85164322.0272NoNoNoNo35
1505x37 6x59 a1_off0.43750240.1904NoNoYesYes34
1516x58 Lig a1_off030.4694NoNoYesYes40
1525x37 6x58 a1_off021.0806NoNoNoNo34
1535x41 6x59 a1_off0.42780330.6632YesNoYesYes44
1545x41 5x45 a1_off2.1119124.618YesNoNoNo44
1555x44 5x45 a1_off2.533121.5788YesYesNoNo54
1565x62 6x38 a1_off015.8049NoYesNoNo66
1576x26 6x30 a1_off011.736NoNoNoNo36
1582x57 7x42 a1_off0.43198913.7788YesYesYesYes67
1593x37 5x461 a1_off3.8106614.6756YesYesYesYes68
1606x44 7x45 a1_off013.1477NoYesNoYes99
1615x58 6x38 a1_off014.731YesNoNoNo96
1623x38 4x53 a1_off1.2789111.8246NoNoNoNo78

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Midway



Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Node1Node2OwnerNet1LinkStrengthNet2LinkStrengthComm1Comm2Node1ShellNode2Shell
1x322x64Shared10.567.920322
1x351x39Shared15.1517.961312
1x352x64Shared10.4656.981312
1x357x35Shared5.965.961311
1x357x39a1_off4.12501312
1x35Liga1_off5.21501310
1x392x57Shared8.888.21322
1x397x42Shared10.46512.311321
2x563x32a1_off4.8100021
2x567x42Shared3.464.150021
2x577x42Shared4.646.631321
3x29E2.I175a1_off3.2500022
3x32LigShared6.616.880010
3x335x39Shared6.455.861312
3x335x40Shared4.242.831311
3x366x48Shared9.7853.640011
3x406x44Shared5.656.280322
4x60E2.I175Shared3.395.081322
4x605x39Shared13.21512.521322
E2.I175E2x52Shared10.67511.30021
E2x52LigShared41.6820.10310
E2.E172LigShared7.497.870010
5x376x55Shared5.614.210321
5x376x58a1_off4.51500321
5x395x40Shared5.3854.791321
5x395x43a1_off4.6501322
5x405x43Shared7.017.011312
5x406x55Shared4.912.81311
5x40Liga1_off3.58501310
6x446x48Shared16.5411.021321
6x447x45a1_off6.64501322
6x477x45Shared9.6857.451322
6x487x41Shared11.7756.061312
6x487x45Shared3.9556.781312
6x48Liga1_off4.82501310
6x51LigShared18.0110.960310
6x547x34a1_off3.68500021
6x55LigShared15.2559.071310
6x58Liga1_off3.80500010
7x317x35Shared3.8155.090021
7x34Liga1_off3.73500010
7x35Liga1_off8.9401310
7x387x42Shared5.3053.980311
7x38LigShared8.846.60310
7x417x42a1_off3.4700021
6x58E3.K265Shared4.5057.510012
1x362x64a1_off2.8304022
6x517x37Shared2.3653.150312
1x317x35a1_off2.06500021
3x334x57a1_off1.7101312
2x607x42Shared1.4654.390021
1x327x35a1_on_gp06.760321
1x351x36a1_on_gp03.631312
1x357x38a1_on_gp08.461311
2x63E2x52a1_on_gp02.510021
2x647x35a1_on_gp06.980321
3x29E2x52a1_on_gp02.770021
3x334x60a1_on_gp03.281312
3x33E2x52a1_on_gp04.871311
3x33Liga1_on_gp03.651310
3x36Liga1_on_gp011.680010
3x406x48a1_on_gp018.790321
E2.E172E2x51a1_on_gp02.540012
5x40E2.I175a1_on_gp02.921312
5x375x40a1_on_gp04.330321
6x476x48a1_on_gp03.711321
6x486x52a1_on_gp03.171312
6x517x38a1_on_gp04.280311
6x517x41a1_on_gp07.370312
6x54E3.K265a1_on_gp04.230022
7x34E3.K265a1_on_gp04.50012
7x42Liga1_on_gp06.791310
1x397x39a1_on_gp02.331322
6x547x37a1_on_gp01.580022

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
Id Description
a1_on_gp 7LD4-A1-Adenosine-Gi2/β1/γ2
a1_off 5UEN-A1-DU172
5N2S-A1-PSB36
Network Difference
Value a1_on_gp a1_off
Imin 2.51 3.005
Number of Linked Nodes 841 284
Number of Specific Nodes 577 (68.61%) 20  (7.04%)
Number of Shared Nodes 264 (31.39%) 264  (92.96%)
Number of Links 1100 316
Number of Specific Links 920 (83.64%) 136  (43.04%)
Number of Shared Links 180 (16.36%) 180  (56.96%)
Number of Hubs 219 34
Number of Specific Hubs 196 (89.50%) 11  (32.35%)
Number of Shared Hubs 23 (10.50%) 23  (67.65%)
Average % Shared Neighbours (Jaccard) 14.28
Average % Shared Neighbours (Otsuka) 17.36
Average % Shared Neighbours (Overlap Coefficient) 20.48
Average % Shared Cliques (k3-6) 50.99
Graphlets Similarity 0.575039
Paths Difference
Value a1_on_gp a1_off
Number Of Nodes in MetaPath 80 85
Specific Nodes in MetaPath 61 (76.25%) 66  (77.65%)
Shared Nodes in MetaPath 264 (31.39%) 264  (31.39%)
Number Of Links MetaPath 84 86
Specific Links in MetaPath 76 (90.48%) 78  (90.70%)
Shared Links in MetaPath 180 (16.36%) 180  (16.36%)
Number of Shortest Paths 6039009 46979
Length Of Smallest Path 3 3
Average Path Length 38.4253 13.6732
Length of Longest Path 64 37
Minimum Path Strength 1.335 0.735
Average Path Strength 6.0545 5.98656
Maximum Path Strength 21.6633 29.845
Minimum Path Correlation 0.7 0.7
Average Path Correlation 0.992674 0.919717
Maximum Path Correlation 1 0.99
Minimum % Of Corr. Nodes 2.5 3.33333
Average % Of Corr. Nodes 28.6895 44.6649
Maximum % Of Corr. Nodes 100 100
Minimum Path Hubs % 0 0
Average Path Hubs % 61.8301 39.7359
Maximum Path Hubs % 100 100

Details about the values in these tables can be found in the corresponding documentation page .

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download a1_off_on_gp.zip<



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