psnGPCR

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Orange: nodes, hubs and links specific of a1_on_allo network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of a1_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	a1_on_allo Int. Strength	a1_on Int. Strength	a1_on_allo Hub1?	a1_on Hub1?	a1_on_allo Hub2?	a1_on Hub2?	ConSurf1	ConSurf2
1	1x41	Alloh17	a1_on_allo	3.74	0	No	No	Yes	No	5	0
2	1x42	Alloh17	a1_on_allo	15.43	0	No	No	Yes	No	7	0
3	1x45	7x47	a1_on_allo	3.39	0	No	No	No	No	4	6
4	1x46	1x50	a1_on_allo	4.47	0	No	No	Yes	No	8	9
5	1x46	2x54	a1_on_allo	3.71	0	No	No	No	No	8	7
6	1x50	2x47	a1_on_allo	3.13	0	Yes	No	No	No	9	9
7	1x53	7x54	a1_on_allo	3.39	0	Yes	No	No	No	9	7
8	1x56	8x53	a1_on_allo	3.36	0	No	No	Yes	No	8	6
9	1x57	1x58	a1_on_allo	4.55	0	No	No	No	No	8	3
10	8x50	I1x50	a1_on_allo	3.65	0	Yes	Yes	No	No	9	8
11	2x37	3x53	a1_on_allo	5.96	0	No	No	Yes	No	7	8
12	2x45	4x50	a1_on_allo	4.94	0	No	No	Yes	No	9	9
13	2x46	3x46	a1_on_allo	4.28	0	Yes	Yes	Yes	No	9	9
14	2x49	4x50	a1_on_allo	3.89	0	No	No	Yes	No	8	9
15	2x56	3x32	a1_on_allo	4.81	0	Yes	No	No	No	6	6
16	2x62	E1x50	a1_on_allo	3.28	0	No	No	No	No	4	3
17	2x63	3x28	a1_on_allo	3.07	0	No	No	No	No	3	6
18	E1x51	E2.V166	a1_on_allo	5.73	0	No	No	No	No	4	3
19	E1x52	E2x50	a1_on_allo	5.07	0	No	No	No	No	7	9
20	3x23	4x61	a1_on_allo	3.94	0	No	No	No	No	1	5
21	3x26	E2.V174	a1_on_allo	4.47	0	No	No	Yes	Yes	5	3
22	3x29	E2.I175	a1_on_allo	3.25	0	No	No	Yes	No	4	3
23	3x30	4x60	a1_on_allo	3.77	0	No	No	Yes	Yes	6	4
24	3x33	5x40	a1_on_allo	4.24	0	Yes	Yes	Yes	No	4	5
25	3x37	4x56	a1_on_allo	7.16	0	Yes	Yes	No	No	6	5
26	3x37	5x43	a1_on_allo	3.96	0	Yes	Yes	No	No	6	5
27	3x50	6x40	a1_on_allo	3.76	0	Yes	No	Yes	No	9	8
28	3x53	I2x54	a1_on_allo	3.71	0	Yes	No	No	No	8	4
29	3x56	I2x56	a1_on_allo	4.61	0	Yes	No	No	No	6	4
30	I2x56	I2x57	a1_on_allo	3.21	0	No	No	No	No	4	7
31	4x40	4x41	a1_on_allo	4.26	0	No	No	No	No	5	5
32	4x56	4x57	a1_on_allo	3.68	0	No	No	No	No	5	6
33	4x58	4x62	a1_on_allo	3.65	0	No	No	No	No	4	4
34	4x59	5x42	a1_on_allo	5.19	0	No	No	Yes	Yes	6	5
35	5x36	E2.W146	a1_on_allo	4.94	0	No	No	Yes	Yes	5	6
36	E2.E153	E2.P165	a1_on_allo	4.72	0	No	No	No	No	2	5
37	5x39	E2.I175	a1_on_allo	3.63	0	Yes	Yes	Yes	No	6	3
38	5x38	5x411	a1_on_allo	7.86	0	No	No	Yes	No	3	4
39	5x40	6x55	a1_on_allo	8.41	0	Yes	No	No	No	5	5
40	5x40	Lig	a1_on_allo	3.73	0	Yes	No	Yes	Yes	5	0
41	5x41	5x45	a1_on_allo	3.93	0	Yes	No	No	No	4	4
42	5x41	6x56	a1_on_allo	5.12	0	Yes	No	No	No	4	5
43	5x411	5x45	a1_on_allo	3.09	0	Yes	No	No	No	4	4
44	5x48	5x49	a1_on_allo	3.28	0	No	No	No	No	5	4
45	5x60	5x63	a1_on_allo	3.37	0	No	No	No	No	4	4
46	5x60	5x64	a1_on_allo	5.3	0	No	No	No	No	4	5
47	5x66	6x30	a1_on_allo	8.14	0	No	No	No	No	5	6
48	6x39	7x52	a1_on_allo	4.47	0	No	No	No	No	6	8
49	6x40	7x52	a1_on_allo	3.07	0	Yes	No	No	No	8	8
50	6x43	7x52	a1_on_allo	4.47	0	No	No	No	No	6	8
51	6x47	Alloh17	a1_on_allo	5.41	0	No	No	Yes	No	8	0
52	6x54	7x33	a1_on_allo	4.15	0	No	No	No	No	4	4
53	6x57	6x61	a1_on_allo	3.27	0	No	No	No	No	4	4
54	7x40	Alloh17	a1_on_allo	8.73	0	No	No	Yes	No	7	0
55	7x41	Lig	a1_on_allo	4.86	0	No	No	Yes	Yes	7	0
56	7x43	Alloh17	a1_on_allo	7.71	0	No	No	Yes	No	5	0
57	7x48	Alloh17	a1_on_allo	17.83	0	No	No	Yes	No	6	0
58	7x55	8x54	a1_on_allo	4.29	0	No	No	No	No	6	7
59	8x47	8x50	a1_on_allo	6.28	0	No	No	Yes	Yes	8	9
60	8x50	8x54	a1_on_allo	8.57	0	Yes	Yes	No	No	9	7
61	8x52	8x56	a1_on_allo	3.04	0	No	No	No	No	4	5
62	4x50	4x54	a1_on_allo	3.01	0	Yes	No	No	No	9	3
63	1x36	2x65	a1_on_allo	2.94	0	No	No	No	No	5	4
64	2x43	3x46	a1_on_allo	2.94	0	No	No	Yes	No	8	9
65	7x48	7x51	a1_on_allo	2.92	0	No	No	No	No	6	7
66	8x47	8x49	a1_on_allo	2.91	0	No	No	No	No	8	6
67	5x65	5x69	a1_on_allo	2.85	0	No	No	No	No	8	4
68	7x47	Alloh17	a1_on_allo	2.84	0	No	No	Yes	No	6	0
69	1x36	2x64	a1_on_allo	2.83	0	No	No	Yes	No	5	3
70	E2.K168	E2x51	a1_on_allo	2.7	0	No	No	No	No	3	4
71	3x51	5x61	a1_on_allo	2.52	0	Yes	No	No	No	7	9
72	5x62	6x33	a1_on_allo	2.51	0	Yes	No	No	No	6	7
73	6x46	Alloh17	a1_on_allo	2.49	0	No	No	Yes	No	6	0
74	3x51	5x57	a1_on_allo	2.42	0	Yes	No	No	No	7	6
75	5x57	5x58	a1_on_allo	2.42	0	No	No	Yes	Yes	6	9
76	1x49	7x50	a1_on_allo	2.03	0	No	No	No	No	8	9
77	7x34	Lig	a1_on_allo	1.94	0	No	No	Yes	Yes	4	0
78	2x38	4x42	a1_on_allo	1.79	0	No	No	No	No	6	7
79	1x33	NT.I5	a1_on_allo	1.62	0	No	No	No	No	5	4
80	1x59	8x53	a1_on_allo	1.59	0	No	No	Yes	No	5	6
81	8x52	8x53	a1_on_allo	1.59	0	No	No	Yes	No	4	6
82	6x36	6x40	a1_on_allo	1.55	0	No	No	Yes	No	8	8
83	1x40	2x61	a1_on_allo	1.54	0	No	No	No	No	4	6
84	6x29	6x33	a1_on_allo	1.45	0	No	No	No	No	6	7
85	6x57	E3.K265	a1_on_allo	1.45	0	No	No	Yes	Yes	4	3
86	8x55	8x56	a1_on_allo	1.41	0	No	No	No	No	5	5
87	E2.A151	E2.R154	a1_on_allo	1.38	0	No	No	No	No	3	2
88	1x32	NT.I5	Shared	6.86	2.74	No	Yes	No	No	4	4
89	1x29	1x32	Shared	7.22	8.66	No	No	No	Yes	6	4
90	1x31	7x32	Shared	15.07	8.79	No	No	No	No	4	1
91	1x32	2x64	Shared	13.2	7.92	No	Yes	Yes	No	4	3
92	1x35	1x39	Shared	14.59	17.96	Yes	Yes	Yes	Yes	5	6
93	1x35	2x64	Shared	12.79	6.98	Yes	Yes	Yes	No	5	3
94	1x35	7x35	Shared	6.95	5.96	Yes	Yes	No	Yes	5	3
95	1x35	7x38	Shared	6.04	8.46	Yes	Yes	No	Yes	5	5
96	1x36	2x61	Shared	8.83	11.77	No	No	No	No	5	6
97	1x38	7x39	Shared	15.07	12.56	No	No	Yes	Yes	5	5
98	1x39	2x57	Shared	9.56	8.2	Yes	Yes	Yes	Yes	6	6
99	1x39	7x39	Shared	3.5	2.33	Yes	Yes	Yes	Yes	6	5
100	1x39	7x42	Shared	14.77	12.31	Yes	Yes	Yes	Yes	6	7
101	1x42	7x39	Shared	3.77	3.77	No	No	Yes	Yes	7	5
102	1x42	7x43	Shared	5.29	1.76	No	No	No	No	7	5
103	1x43	2x57	Shared	4.87	4.87	No	No	Yes	Yes	5	6
104	1x46	7x46	Shared	4.89	4.89	No	No	No	No	8	9
105	1x47	1x48	Shared	3.53	5.3	No	No	No	No	6	4
106	1x47	2x51	Shared	3.21	3.21	No	No	No	No	6	7
107	1x49	1x52	Shared	3.42	1.71	No	No	No	No	8	7
108	1x50	2x50	Shared	6.73	6.73	Yes	No	Yes	Yes	9	9
109	1x50	7x50	Shared	11.4	11.4	Yes	No	No	No	9	9
110	1x53	2x47	Shared	3.39	3.39	Yes	No	No	No	9	9
111	1x53	7x50	Shared	3.53	3.53	Yes	No	No	No	9	9
112	1x53	8x50	Shared	3.93	7.87	Yes	No	Yes	Yes	9	9
113	1x54	2x44	Shared	4.61	4.61	No	No	No	No	7	5
114	1x54	2x47	Shared	3.25	3.25	No	No	No	No	7	9
115	1x54	2x48	Shared	3.07	1.54	No	No	No	No	7	6
116	1x55	1x59	Shared	7.36	6.13	No	No	No	No	4	5
117	1x57	2x44	Shared	8.02	3.21	No	No	No	No	8	5
118	1x60	I1x50	Shared	10.98	6.87	No	No	No	No	6	8
119	1x60	8x53	Shared	8.77	4.39	No	No	Yes	No	6	6
120	2x40	I1x50	Shared	12.18	18.27	No	Yes	No	No	8	8
121	2x37	I2x54	Shared	5.53	4.15	No	No	No	No	7	4
122	2x39	3x49	Shared	11.56	8.67	No	No	No	No	8	9
123	2x39	3x53	Shared	11.64	6.47	No	No	Yes	No	8	8
124	2x40	8x47	Shared	6.28	6.28	No	Yes	No	No	8	8
125	2x40	8x50	Shared	5.36	4.29	No	Yes	Yes	Yes	8	9
126	2x42	3x49	Shared	8.36	7.17	Yes	Yes	No	No	8	9
127	2x42	4x46	Shared	5.02	3.77	Yes	Yes	No	No	8	8
128	2x45	4x46	Shared	10.84	9.29	No	No	No	No	9	8
129	2x46	2x50	Shared	8.14	6.79	Yes	Yes	Yes	Yes	9	9
130	2x46	3x42	Shared	4.73	3.15	Yes	Yes	No	No	9	8
131	2x46	3x43	Shared	5.54	5.54	Yes	Yes	No	No	9	8
132	2x46	7x49	Shared	9.61	10.98	Yes	Yes	No	Yes	9	9
133	2x50	3x39	Shared	5.89	5.89	Yes	Yes	No	No	9	9
134	2x50	7x46	Shared	5.89	4.42	Yes	Yes	No	No	9	9
135	2x50	7x49	Shared	10.77	10.77	Yes	Yes	No	Yes	9	9
136	2x52	3x35	Shared	6.3	3.15	No	No	No	No	6	7
137	2x53	2x56	Shared	6.41	6.41	No	No	Yes	No	8	6
138	2x53	7x46	Shared	6.46	8.08	No	No	No	No	8	9
139	2x56	3x35	Shared	4.47	4.47	Yes	No	No	No	6	7
140	2x56	7x42	Shared	4.15	4.15	Yes	No	Yes	Yes	6	7
141	2x57	7x42	Shared	3.98	6.63	Yes	Yes	Yes	Yes	6	7
142	2x59	3x31	Shared	3.28	3.28	No	No	No	No	5	4
143	2x60	7x42	Shared	4.39	4.39	No	No	Yes	Yes	7	7
144	2x62	3x28	Shared	4.47	5.96	No	No	No	No	4	6
145	2x63	E2x52	Shared	5.02	2.51	No	No	Yes	Yes	3	4
146	2x64	7x35	Shared	5.81	6.98	Yes	No	No	Yes	3	3
147	2x66	E1x50	Shared	4.06	4.06	No	No	No	No	3	3
148	2x66	E2.K168	Shared	5.23	3.49	No	No	No	No	3	3
149	E1x50	E1x52	Shared	5.25	3.5	No	No	No	No	3	7
150	3x24	E1x52	Shared	3.14	3.14	No	No	No	No	5	7
151	3x21	E2.E164	Shared	14.59	7.86	No	No	No	No	6	3
152	3x22	3x26	Shared	4.87	3.65	Yes	Yes	No	No	3	5
153	3x22	E2.N147	Shared	4.83	4.83	Yes	Yes	Yes	Yes	3	6
154	3x22	E2.L149	Shared	10.96	4.87	Yes	Yes	No	No	3	4
155	3x22	E2.V152	Shared	3.93	3.93	Yes	Yes	No	No	3	1
156	3x22	E2.I167	Shared	3.77	2.51	Yes	Yes	No	No	3	4
157	3x22	E2.V174	Shared	6.55	6.55	Yes	Yes	Yes	Yes	3	3
158	3x23	3x27	Shared	5.25	5.25	No	No	No	No	1	4
159	3x25	E2x50	Shared	7.28	7.28	No	No	No	No	9	9
160	3x25	E2.V174	Shared	6.83	5.12	No	No	Yes	Yes	9	3
161	3x26	E2.N147	Shared	4.12	6.87	No	No	Yes	Yes	5	6
162	3x30	4x61	Shared	4.86	4.86	No	No	No	No	6	5
163	3x32	Lig	Shared	6.87	6.87	No	No	Yes	Yes	6	0
164	3x33	4x60	Shared	3.28	3.28	Yes	Yes	Yes	Yes	4	4
165	3x33	E2x52	Shared	4.87	4.87	Yes	Yes	Yes	Yes	4	4
166	3x33	5x39	Shared	4.69	5.86	Yes	Yes	Yes	Yes	4	6
167	3x33	Lig	Shared	3.65	3.65	Yes	Yes	Yes	Yes	4	0
168	3x34	4x54	Shared	10.05	12.56	No	Yes	No	No	5	3
169	3x36	6x48	Shared	4.85	3.64	No	No	Yes	Yes	6	8
170	3x36	Lig	Shared	6.8	11.66	No	No	Yes	Yes	6	0
171	3x37	3x40	Shared	4.12	4.12	Yes	Yes	Yes	Yes	6	8
172	3x37	3x41	Shared	5.32	7.99	Yes	Yes	No	No	6	4
173	3x37	5x461	Shared	5.48	7.67	Yes	Yes	Yes	Yes	6	8
174	3x38	4x50	Shared	14.83	12.36	No	No	Yes	No	7	9
175	3x38	4x53	Shared	6.52	4.89	No	No	No	No	7	8
176	3x40	5x50	Shared	3.39	3.39	Yes	Yes	No	No	8	8
177	3x40	6x44	Shared	7.54	6.28	Yes	Yes	No	No	8	9
178	3x40	6x48	Shared	15.27	18.79	Yes	Yes	Yes	Yes	8	8
179	3x41	4x49	Shared	3.17	3.17	No	No	No	No	4	7
180	3x43	7x53	Shared	7.03	4.69	No	No	Yes	Yes	8	9
181	3x44	5x53	Shared	4.15	2.77	No	No	No	No	7	6
182	3x46	3x50	Shared	5.01	6.26	Yes	No	Yes	No	9	9
183	3x46	7x53	Shared	6.04	6.04	Yes	No	Yes	Yes	9	9
184	3x47	5x58	Shared	4	4	No	No	Yes	Yes	9	9
185	3x49	I2x53	Shared	5.75	5.75	No	No	Yes	Yes	9	7
186	3x50	5x58	Shared	6.17	4.12	Yes	No	Yes	Yes	9	9
187	3x50	7x53	Shared	5.14	8.23	Yes	No	Yes	Yes	9	9
188	3x51	3x55	Shared	13.14	13.14	Yes	No	No	No	7	7
189	3x51	5x60	Shared	6.73	5.61	Yes	No	No	No	7	4
190	3x52	3x56	Shared	4.28	4.28	No	No	Yes	No	5	6
191	3x53	I2x53	Shared	22.64	25.72	Yes	No	Yes	Yes	8	7
192	3x56	I2x52	Shared	7.52	6.26	Yes	No	No	No	6	5
193	I2x53	I2x54	Shared	5.97	8.36	Yes	Yes	No	No	7	4
194	I2x53	I2x57	Shared	12.62	7.57	Yes	Yes	No	No	7	7
195	4x38	4x41	Shared	9.06	5.17	No	No	No	No	8	5
196	4x52	5x461	Shared	10.25	6.83	No	No	Yes	Yes	4	8
197	4x56	5x461	Shared	11.03	13.48	No	No	Yes	Yes	5	8
198	4x59	5x39	Shared	8.74	3.75	No	No	Yes	Yes	6	6
199	4x60	E2.I175	Shared	3.39	5.08	Yes	Yes	Yes	No	4	3
200	4x60	5x39	Shared	9.74	12.52	Yes	Yes	Yes	Yes	4	6
201	5x38	E2.W146	Shared	3.27	3.27	No	No	Yes	Yes	3	6
202	5x39	E2.W146	Shared	5.79	7.72	Yes	Yes	Yes	Yes	6	6
203	5x42	E2.W146	Shared	4.01	5.01	Yes	Yes	Yes	Yes	5	6
204	E2.L149	E2.N147	Shared	5.49	4.12	No	No	Yes	Yes	4	6
205	5x36	E2.N148	Shared	4.47	2.98	No	No	No	No	5	4
206	E2.E153	E2.L149	Shared	9.28	7.95	No	No	No	No	2	4
207	E2.S161	E2.W156	Shared	14.83	14.83	No	No	No	No	6	1
208	E2.P165	E2.W156	Shared	9.46	12.16	No	No	No	No	5	1
209	E2.E164	E2.P165	Shared	3.14	3.14	No	No	No	No	3	5
210	E2.I167	E2.K173	Shared	8.72	2.91	No	No	No	No	4	3
211	E2.I175	E2x52	Shared	7.54	11.3	Yes	No	Yes	Yes	3	4
212	E2x52	Lig	Shared	23.28	20.06	Yes	Yes	Yes	Yes	4	0
213	E2.E172	Lig	Shared	7.86	7.86	No	No	Yes	Yes	4	0
214	E2.I175	E2.V174	Shared	3.07	3.07	Yes	No	Yes	Yes	3	3
215	5x37	5x40	Shared	4.33	4.33	No	No	Yes	No	3	5
216	5x37	6x55	Shared	5.61	4.21	No	No	No	No	3	5
217	5x39	5x42	Shared	8.25	4.13	Yes	Yes	Yes	Yes	6	5
218	5x40	5x43	Shared	5.61	7.01	Yes	No	No	No	5	5
219	5x41	5x411	Shared	3.79	3.79	Yes	No	Yes	No	4	4
220	5x41	6x59	Shared	5.96	5.96	Yes	No	No	Yes	4	4
221	5x411	6x59	Shared	7.03	4.69	Yes	No	No	Yes	4	4
222	5x411	6x60	Shared	7.22	7.22	Yes	No	No	No	4	4
223	5x42	5x461	Shared	7.02	9.02	Yes	Yes	Yes	Yes	5	8
224	5x44	5x45	Shared	8.57	7.5	Yes	Yes	No	No	5	4
225	5x44	5x47	Shared	3.93	3.93	Yes	Yes	No	No	5	5
226	5x44	5x48	Shared	6.09	4.87	Yes	Yes	No	No	5	5
227	5x44	6x52	Shared	16.97	15.84	Yes	Yes	No	No	5	7
228	5x46	5x461	Shared	9.81	8.58	No	No	Yes	Yes	5	8
229	5x47	6x52	Shared	6.92	12.45	No	No	No	No	5	7
230	5x49	5x50	Shared	5.84	5.84	No	No	No	No	4	8
231	5x51	6x44	Shared	7.31	7.31	No	No	No	No	6	9
232	5x51	6x49	Shared	4.15	4.15	No	No	No	No	6	7
233	5x58	6x37	Shared	5.86	8.21	Yes	Yes	No	No	9	8
234	5x58	6x40	Shared	4.84	7.25	Yes	Yes	Yes	No	9	8
235	5x58	6x41	Shared	7.03	8.21	Yes	Yes	No	No	9	8
236	5x61	5x65	Shared	3.07	3.07	No	No	No	No	9	8
237	5x62	5x66	Shared	3.21	3.21	Yes	No	No	No	6	5
238	5x62	6x30	Shared	4.66	5.83	Yes	No	No	No	6	6
239	5x62	6x34	Shared	4.16	2.77	Yes	No	No	No	6	7
240	5x65	6x33	Shared	4.42	4.42	No	No	No	No	8	7
241	5x68	5x71	Shared	6.78	6.78	No	No	No	No	7	3
242	6x25	6x26	Shared	9.55	9.55	No	No	No	No	3	3
243	6x27	6x31	Shared	4.69	4.69	No	No	No	No	1	5
244	6x36	7x56	Shared	3.95	10.54	No	No	No	No	8	7
245	6x39	6x43	Shared	4.15	5.54	No	No	No	No	6	6
246	6x40	7x53	Shared	9.67	3.63	Yes	No	Yes	Yes	8	9
247	6x42	6x46	Shared	7.31	8.53	No	No	No	No	5	6
248	6x43	7x48	Shared	4.24	7.07	No	No	No	No	6	6
249	6x44	6x48	Shared	11.02	11.02	No	No	Yes	Yes	9	8
250	6x47	6x48	Shared	3.71	3.71	No	No	Yes	Yes	8	8
251	6x47	7x45	Shared	8.94	7.45	No	No	No	No	8	9
252	6x48	6x52	Shared	4.23	3.17	Yes	Yes	No	No	8	7
253	6x48	7x41	Shared	8.49	6.06	Yes	Yes	No	No	8	7
254	6x48	7x45	Shared	6.78	6.78	Yes	Yes	No	No	8	9
255	6x50	7x40	Shared	3.28	1.64	No	No	No	No	9	7
256	6x51	7x37	Shared	3.15	3.15	No	Yes	No	No	6	5
257	6x51	7x41	Shared	7.37	7.37	No	Yes	No	No	6	7
258	6x51	Lig	Shared	16.42	10.94	No	Yes	Yes	Yes	6	0
259	6x54	E3.K265	Shared	5.64	4.23	No	No	Yes	Yes	4	3
260	6x55	Lig	Shared	9.95	9.05	No	No	Yes	Yes	5	0
261	6x61	E3.C263	Shared	7.28	7.28	No	No	No	No	4	2
262	7x34	E3.K265	Shared	6.01	4.5	No	No	Yes	Yes	4	3
263	7x30	7x33	Shared	3.28	9.85	No	No	No	No	4	4
264	7x31	7x35	Shared	7.63	5.09	No	No	No	Yes	3	3
265	7x32	7x36	Shared	4.42	4.42	No	No	No	No	1	3
266	7x36	7x39	Shared	6.28	7.54	No	No	Yes	Yes	3	5
267	7x38	Lig	Shared	4.7	6.58	No	Yes	Yes	Yes	5	0
268	7x42	Lig	Shared	10.17	6.78	Yes	Yes	Yes	Yes	7	0
269	7x45	7x49	Shared	9.54	10.9	No	No	No	Yes	9	9
270	7x54	8x50	Shared	8.32	8.32	No	No	Yes	Yes	7	9
271	7x55	8x51	Shared	8.55	7.48	No	No	No	No	6	8
272	8x48	8x51	Shared	12.85	10.51	No	No	No	No	4	8
273	6x58	E3.K265	Shared	3	7.51	No	No	Yes	Yes	4	3
274	3x54	5x64	Shared	2.98	5.96	No	No	No	No	9	5
275	5x55	6x41	Shared	2.98	4.47	No	No	No	No	5	8
276	1x50	2x51	Shared	2.96	2.96	Yes	No	No	No	9	7
277	2x61	2x65	Shared	2.94	1.47	No	No	No	No	6	4
278	3x37	4x53	Shared	2.89	2.89	Yes	Yes	No	No	6	8
279	6x29	6x32	Shared	2.87	4.31	No	No	No	No	6	7
280	3x34	4x58	Shared	2.85	2.85	No	Yes	No	No	5	4
281	5x54	6x41	Shared	2.83	2.83	No	No	No	No	8	8
282	5x64	5x67	Shared	2.82	2.82	No	No	No	No	5	4
283	6x31	6x35	Shared	2.82	2.82	No	No	No	No	5	7
284	2x42	3x45	Shared	2.77	2.77	Yes	Yes	No	No	8	7
285	2x42	4x42	Shared	2.77	2.77	Yes	Yes	No	No	8	7
286	2x42	4x45	Shared	2.77	1.39	Yes	Yes	No	No	8	5
287	5x48	5x52	Shared	2.77	2.77	No	No	No	No	5	3
288	5x58	5x61	Shared	2.52	2.52	Yes	Yes	No	No	9	9
289	I2x52	I2x55	Shared	2.48	2.48	No	No	No	No	5	5
290	E2.V166	E2.W156	Shared	2.45	3.68	No	No	No	No	3	1
291	3x30	3x31	Shared	1.88	3.77	No	No	No	No	6	4
292	6x61	E3.P261	Shared	1.88	1.88	No	No	No	No	4	4
293	1x37	1x40	Shared	1.84	1.84	No	No	No	No	5	4
294	2x41	4x42	Shared	1.81	3.61	No	No	No	No	4	7
295	4x38	4x39	Shared	1.75	5.25	No	No	No	No	8	3
296	E2.G163	E2.M162	Shared	1.75	1.75	No	No	No	No	4	4
297	4x63	E2.N147	Shared	1.7	3.39	No	No	Yes	Yes	5	6
298	2x57	2x58	Shared	1.69	3.39	Yes	Yes	No	No	6	8
299	3x56	I2x50	Shared	1.69	1.69	Yes	No	No	No	6	8
300	3x44	5x50	Shared	1.64	3.28	No	No	No	No	7	8
301	6x45	6x49	Shared	1.58	1.58	No	No	No	No	6	7
302	1x60	I1x49	Shared	1.56	4.69	No	No	No	No	6	6
303	3x48	5x57	Shared	1.54	3.07	No	No	No	No	6	6
304	6x53	6x57	Shared	1.47	1.47	No	No	No	No	6	4
305	2x551	3x35	Shared	1.38	5.54	No	No	No	No	5	7
306	1x57	I1x51	Shared	1.31	1.31	No	No	No	No	8	7
307	5x66	5x70	Shared	1.21	6.03	No	No	No	No	5	5
308	I1x48	I1x51	Shared	1.17	2.34	No	No	No	No	6	7
309	6x27	6x30	Shared	1.12	2.24	No	No	No	No	1	6
310	1x32	7x35	a1_on	0	6.76	No	Yes	No	Yes	4	3
311	1x35	1x36	a1_on	0	3.63	Yes	Yes	No	No	5	5
312	1x39	2x61	a1_on	0	4.1	Yes	Yes	No	No	6	6
313	1x46	7x47	a1_on	0	3.42	No	No	No	No	8	6
314	1x52	8x54	a1_on	0	4.87	No	No	No	No	7	7
315	8x49	I1x50	a1_on	0	4.23	No	No	No	No	6	8
316	2x37	2x39	a1_on	0	4.34	No	No	No	No	7	8
317	2x37	2x40	a1_on	0	7.17	No	No	No	Yes	7	8
318	2x49	3x38	a1_on	0	3.42	No	No	No	No	8	7
319	2x53	2x54	a1_on	0	3.68	No	No	No	No	8	7
320	3x25	3x28	a1_on	0	3.42	No	No	No	No	9	6
321	3x27	4x61	a1_on	0	4.33	No	No	No	No	4	5
322	3x34	4x53	a1_on	0	3.1	No	Yes	No	No	5	8
323	3x34	4x57	a1_on	0	5.29	No	Yes	No	No	5	6
324	3x40	5x47	a1_on	0	4.61	Yes	Yes	No	No	8	5
325	3x43	7x49	a1_on	0	6.87	No	No	No	Yes	8	9
326	3x47	5x57	a1_on	0	3.25	No	No	No	No	9	6
327	3x54	5x65	a1_on	0	3.07	No	No	No	No	9	8
328	4x48	4x51	a1_on	0	3.53	No	No	No	No	1	4
329	4x56	5x42	a1_on	0	5.24	No	No	Yes	Yes	5	5
330	4x59	4x60	a1_on	0	3.5	No	No	Yes	Yes	6	4
331	4x59	E2.W146	a1_on	0	4.85	No	No	Yes	Yes	6	6
332	E2.A151	E2.N148	a1_on	0	3.13	No	No	No	No	3	4
333	E2.P165	E2.V152	a1_on	0	3.53	No	No	No	No	5	1
334	E2.V174	E2x50	a1_on	0	3.42	Yes	Yes	No	No	3	9
335	5x36	5x38	a1_on	0	7.19	No	No	No	No	5	3
336	5x39	5x40	a1_on	0	4.79	Yes	Yes	Yes	No	6	5
337	5x63	5x66	a1_on	0	6.17	No	No	No	No	4	5
338	6x51	7x38	a1_on	0	4.28	No	Yes	No	Yes	6	5
339	6x59	6x60	a1_on	0	3.65	No	Yes	No	No	4	4
340	7x38	7x42	a1_on	0	3.98	No	Yes	Yes	Yes	5	7
341	7x39	7x40	a1_on	0	3.65	Yes	Yes	No	No	5	7
342	I2x55	I2x56	a1_on	0	3.04	No	No	No	No	5	4
343	8x48	8x52	a1_on	0	2.87	No	No	No	No	4	4
344	6x54	6x57	a1_on	0	2.85	No	No	No	No	4	4
345	5x37	6x59	a1_on	0	2.83	No	No	No	Yes	3	4
346	3x55	5x64	a1_on	0	2.82	No	No	No	No	7	5
347	6x56	6x60	a1_on	0	2.79	No	No	No	No	5	4
348	1x56	8x50	a1_on	0	2.77	No	No	Yes	Yes	8	9
349	3x29	E2x52	a1_on	0	2.77	No	No	Yes	Yes	4	4
350	3x23	3x26	a1_on	0	2.57	No	No	No	No	1	5
351	E2.E172	E2x51	a1_on	0	2.54	No	No	No	No	4	4
352	7x52	7x53	a1_on	0	2.52	No	No	Yes	Yes	8	9
353	2x40	2x43	a1_on	0	2.51	No	Yes	No	No	8	8
354	3x21	3x24	a1_on	0	2.5	No	No	No	No	6	5
355	6x42	6x43	a1_on	0	2.44	No	No	No	No	5	6
356	8x54	8x55	a1_on	0	2.44	No	No	No	No	7	5
357	8x51	8x55	a1_on	0	2.43	No	No	No	No	8	5
358	3x51	3x52	a1_on	0	2.34	Yes	No	No	No	7	5
359	3x52	I2x53	a1_on	0	2.34	No	No	Yes	Yes	5	7
360	1x55	1x58	a1_on	0	2.32	No	No	No	No	4	3
361	1x52	1x55	a1_on	0	2.28	No	No	No	No	7	4
362	1x48	1x49	a1_on	0	2.03	No	No	No	No	4	8
363	1x36	1x37	a1_on	0	1.76	No	No	No	No	5	5
364	2x38	I2x57	a1_on	0	1.7	No	No	No	No	6	7
365	7x30	E3.K265	a1_on	0	1.67	No	No	Yes	Yes	4	3
366	6x49	6x50	a1_on	0	1.64	No	No	No	No	7	9
367	E2.A157	E2.M162	a1_on	0	1.61	No	No	No	No	1	4
368	4x55	4x56	a1_on	0	1.6	No	No	No	No	4	5
369	2x55	2x551	a1_on	0	1.58	No	No	No	No	4	5
370	5x51	6x45	a1_on	0	1.58	No	No	No	No	6	6
371	6x54	7x37	a1_on	0	1.58	No	No	No	No	4	5
372	7x51	7x52	a1_on	0	1.54	No	No	No	No	7	8
373	6x47	7x48	a1_on	0	1.53	No	No	No	No	8	6
374	1x40	1x44	a1_on	0	1.49	No	No	No	No	4	5
375	2x65	NT.I5	a1_on	0	1.47	No	No	No	No	4	4
376	1x38	1x41	a1_on	0	1.43	No	No	No	No	5	5
377	1x41	1x42	a1_on	0	1.43	No	No	No	No	5	7
378	5x69	6x33	a1_on	0	1.43	No	No	No	No	4	7
379	1x30	1x31	a1_on	0	1.39	No	No	No	No	5	4
380	E3.H264	E3.S262	a1_on	0	1.39	No	No	No	No	2	3
381	5x69	5x70	a1_on	0	1.37	No	No	No	No	4	5
382	E2.R154	E2.S150	a1_on	0	1.32	No	No	No	No	2	2
383	4x38	4x40	a1_on	0	1.29	No	No	No	No	8	5
384	6x39	7x56	a1_on	0	1.21	No	No	No	No	6	7

Orange: nodes, hubs and links specific of a1_on_allo network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of a1_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	a1_on_allo Avg Int. Strength	a1_on Avg Int. Strength	a1_on_allo Num Of Links	a1_on Num Of Links	ConSurf
1	1x50	a1_on_allo	5.738	7.03	5	3	9
2	1x53	a1_on_allo	3.56	4.93	4	3	9
3	2x56	a1_on_allo	4.96	5.01	4	3	6
4	2x64	a1_on_allo	8.6575	7.29333	4	3	3
5	3x46	a1_on_allo	4.5675	6.15	4	2	9
6	3x50	a1_on_allo	5.02	6.20333	4	3	9
7	3x51	a1_on_allo	6.2025	7.03	4	3	7
8	3x53	a1_on_allo	10.9875	16.095	4	2	8
9	3x56	a1_on_allo	4.525	4.07667	4	3	6
10	4x50	a1_on_allo	6.6675	12.36	4	1	9
11	E2.I175	a1_on_allo	4.176	6.48333	5	3	3
12	5x40	a1_on_allo	5.264	5.37667	5	3	5
13	5x41	a1_on_allo	4.7	4.875	4	2	4
14	5x411	a1_on_allo	5.798	5.23333	5	3	4
15	5x62	a1_on_allo	3.635	3.93667	4	3	6
16	6x40	a1_on_allo	4.578	5.44	5	2	8
17	8x53	a1_on_allo	3.8275	4.39	4	1	6
18	Alloh17	a1_on_allo	8.0225	0	8	0	0
19	1x35	Shared	10.0925	8.598	4	5	5
20	1x39	Shared	10.605	8.98	4	5	6
21	2x42	Shared	4.338	3.574	5	5	8
22	2x46	Shared	6.46	6.615	5	4	9
23	2x50	Shared	7.484	6.92	5	5	9
24	2x57	Shared	5.025	5.7725	4	4	6
25	3x22	Shared	5.81833	4.39	6	6	3
26	3x33	Shared	4.146	4.415	5	4	4
27	3x37	Shared	4.82167	5.6675	6	4	6
28	3x40	Shared	7.58	7.438	4	5	8
29	I2x53	Shared	11.745	9.948	4	5	7
30	4x60	Shared	5.045	6.095	4	4	4
31	E2.W146	Shared	4.5025	5.2125	4	4	6
32	E2.N147	Shared	4.035	4.8025	4	4	6
33	E2x52	Shared	10.1775	8.302	4	5	4
34	E2.V174	Shared	5.23	4.54	4	4	3
35	5x39	Shared	6.80667	6.46167	6	6	6
36	5x42	Shared	6.1175	5.85	4	4	5
37	5x44	Shared	8.89	8.035	4	4	5
38	5x461	Shared	8.718	9.116	5	5	8
39	5x58	Shared	4.69143	5.71833	7	6	9
40	6x48	Shared	7.76429	7.59571	7	7	8
41	E3.K265	Shared	4.025	4.4775	4	4	3
42	7x39	Shared	7.155	5.97	4	5	5
43	7x42	Shared	7.492	6.37333	5	6	7
44	7x53	Shared	6.97	5.022	4	5	9
45	8x50	Shared	6.01833	5.8125	6	4	9
46	Lig	Shared	8.3525	9.27222	12	9	0
47	1x32	a1_on	9.09333	6.52	3	4	4
48	2x40	a1_on	7.94	7.704	3	5	8
49	3x34	a1_on	6.45	5.95	2	4	5
50	6x51	a1_on	8.98	6.435	3	4	6
51	6x59	a1_on	6.495	4.2825	2	4	4
52	7x35	a1_on	6.79667	6.1975	3	4	3
53	7x38	a1_on	5.37	5.825	2	4	5
54	7x49	a1_on	9.97333	9.88	3	4	9

Orange: nodes, hubs and links specific of a1_on_allo network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of a1_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	a1_on_allo Recurrence	a1_on Recurrence	a1_on_allo Hub1?	a1_on Hub1?	a1_on_allo Hub2?	a1_on Hub2?	ConSurf1	ConSurf2
1	1x35	1x39	a1_on_allo	10.2935	7.29517	Yes	Yes	Yes	Yes	5	6
2	1x35	2x64	a1_on_allo	15.0724	9.04602	Yes	Yes	Yes	No	5	3
3	1x46	7x46	a1_on_allo	38.1348	4.06846	No	No	No	No	8	9
4	1x46	1x50	a1_on_allo	37.1511	0	No	No	Yes	No	8	9
5	1x50	2x47	a1_on_allo	69.1874	0	Yes	No	No	No	9	9
6	1x54	2x44	a1_on_allo	13.0129	8.99551	No	No	No	No	7	5
7	8x50	I1x50	a1_on_allo	50.5439	0	Yes	Yes	No	No	9	8
8	1x60	I1x50	a1_on_allo	45.633	6.1055	No	No	No	No	6	8
9	1x60	8x53	a1_on_allo	35.5475	2.04265	No	No	Yes	No	6	6
10	1x59	8x53	a1_on_allo	10.1936	0	No	No	Yes	No	5	6
11	1x57	2x44	a1_on_allo	10.4255	6.76206	No	No	No	No	8	5
12	5x40	Lig	a1_on_allo	14.5205	0	Yes	No	Yes	Yes	5	0
13	5x40	5x43	a1_on_allo	13.1848	3.38945	Yes	No	No	No	5	5
14	3x37	5x43	a1_on_allo	13.1768	0	Yes	Yes	No	No	6	5
15	3x38	4x53	a1_on_allo	36.4992	5.17957	No	No	No	No	7	8
16	3x38	4x50	a1_on_allo	35.4395	1.73401	No	No	Yes	No	7	9
17	2x45	4x50	a1_on_allo	28.9131	0	No	No	Yes	No	9	9
18	2x45	4x46	a1_on_allo	27.7973	1.93042	No	No	No	No	9	8
19	2x42	4x46	a1_on_allo	26.6736	3.85522	Yes	Yes	No	No	8	8
20	3x49	I2x53	a1_on_allo	14.9444	2.13244	No	No	Yes	Yes	9	7
21	8x47	8x50	a1_on_allo	10.1696	0	No	No	Yes	Yes	8	9
22	2x46	7x49	a1_on_allo	44.5333	1.66667	Yes	Yes	No	Yes	9	9
23	7x41	Lig	a1_on_allo	41.0342	0	No	No	Yes	Yes	7	0
24	2x46	3x46	a1_on_allo	53.6111	0	Yes	Yes	Yes	No	9	9
25	3x32	Lig	a1_on_allo	34.2158	1.90236	No	No	Yes	Yes	6	0
26	3x33	4x60	a1_on_allo	17.8197	3.00786	Yes	Yes	Yes	Yes	4	4
27	3x30	4x60	a1_on_allo	17.2639	0	No	No	Yes	Yes	6	4
28	2x63	E2x52	a1_on_allo	24.874	1.96409	No	No	Yes	Yes	3	4
29	2x63	3x28	a1_on_allo	21.9747	0	No	No	No	No	3	6
30	2x62	3x28	a1_on_allo	19.0754	1.7789	No	No	No	No	4	6
31	2x62	E1x50	a1_on_allo	16.2481	0	No	No	No	No	4	3
32	3x25	E2.V174	a1_on_allo	11.5252	5.47699	No	No	Yes	Yes	9	3
33	3x22	E2.L149	a1_on_allo	24.2942	3.68687	Yes	Yes	No	No	3	4
34	E2.E153	E2.L149	a1_on_allo	21.8987	1.99214	No	No	No	No	2	4
35	E2.E153	E2.P165	a1_on_allo	19.1874	0	No	No	No	No	2	5
36	E2.P165	E2.W156	a1_on_allo	11.0174	5.83614	No	No	No	No	5	1
37	7x48	Alloh17	a1_on_allo	13.5408	0	No	No	Yes	No	6	0
38	6x43	7x48	a1_on_allo	11.4133	9.9046	No	No	No	No	6	6
39	6x43	7x52	a1_on_allo	10.1176	0	No	No	No	No	6	8
40	6x40	7x52	a1_on_allo	11.1133	0	Yes	No	No	No	8	8
41	3x46	3x50	a1_on_allo	45.901	0.224467	Yes	No	Yes	No	9	9
42	5x57	5x58	a1_on_allo	12.2371	0	No	No	Yes	Yes	6	9
43	3x51	5x60	a1_on_allo	13.8287	2.49719	Yes	No	No	No	7	4
44	5x39	E2.W146	a1_on_allo	10.5255	8.43995	Yes	Yes	Yes	Yes	6	6
45	6x48	6x52	a1_on_allo	13.5687	9.05724	Yes	Yes	No	No	8	7
46	5x44	6x52	a1_on_allo	10.5575	5.98765	Yes	Yes	No	No	5	7
47	5x62	6x33	a1_on_allo	11.3093	0	Yes	No	No	No	6	7
48	6x47	Alloh17	a1_on_allo	20.655	0	No	No	Yes	No	8	0
49	6x47	6x48	a1_on_allo	16.5	7.41302	No	No	Yes	Yes	8	8
50	7x34	Lig	a1_on_allo	29.3889	0	No	No	Yes	Yes	4	0
51	7x34	E3.K265	a1_on_allo	26.9495	1.85746	No	No	Yes	Yes	4	3
52	6x57	E3.K265	a1_on_allo	13.5727	0	No	No	Yes	Yes	4	3
53	8x50	8x54	a1_on_allo	20.3271	0	Yes	Yes	No	No	9	7
54	7x55	8x54	a1_on_allo	15.2563	0	No	No	No	No	6	7
55	7x55	8x51	a1_on_allo	10.1776	2.31201	No	No	No	No	6	8
56	8x52	8x53	a1_on_allo	15.2803	0	No	No	Yes	No	4	6
57	8x52	8x56	a1_on_allo	10.1936	0	No	No	No	No	4	5
58	2x56	3x32	a1_on_allo	34.0958	0	Yes	No	No	No	6	6
59	1x39	7x39	Shared	10.1296	25.0337	Yes	Yes	Yes	Yes	6	5
60	1x39	7x42	Shared	13.7687	37.1324	Yes	Yes	Yes	Yes	6	7
61	2x56	7x42	Shared	46.6448	57.4467	Yes	No	Yes	Yes	6	7
62	2x53	2x56	Shared	77.6334	57.615	No	No	Yes	No	8	6
63	2x53	7x46	Shared	77.0455	58.0976	No	No	No	No	8	9
64	2x50	7x46	Shared	41.526	59.4444	Yes	Yes	No	No	9	9
65	1x50	2x50	Shared	100	94.1526	Yes	No	Yes	Yes	9	9
66	1x50	7x50	Shared	56.7824	68.1987	Yes	No	No	No	9	9
67	1x53	2x47	Shared	49.928	15.6285	Yes	No	No	No	9	9
68	1x53	7x50	Shared	49.5601	66.4198	Yes	No	No	No	9	9
69	1x53	8x50	Shared	89.3306	51.9641	Yes	No	Yes	Yes	9	9
70	1x54	2x47	Shared	18.1636	13.4287	No	No	No	No	7	9
71	7x38	Lig	Shared	11.9411	13.9001	No	Yes	Yes	Yes	5	0
72	3x37	4x53	Shared	37.551	13.5971	Yes	Yes	No	No	6	8
73	2x42	3x49	Shared	19.7473	12.8339	Yes	Yes	No	No	8	9
74	2x46	2x50	Shared	17.9717	20.0281	Yes	Yes	Yes	Yes	9	9
75	3x36	Lig	Shared	41.0421	68.5802	No	No	Yes	Yes	6	0
76	3x36	6x48	Shared	41.3861	68.8664	No	No	Yes	Yes	6	8
77	6x48	7x45	Shared	93.3536	94.5062	Yes	Yes	No	No	8	9
78	7x45	7x49	Shared	98.0285	100	No	No	No	Yes	9	9
79	6x48	7x41	Shared	42.9297	18.2772	Yes	Yes	No	No	8	7
80	3x33	Lig	Shared	31.1685	19.1863	Yes	Yes	Yes	Yes	4	0
81	E2x52	Lig	Shared	81.4285	53.0696	Yes	Yes	Yes	Yes	4	0
82	E2.I175	E2x52	Shared	58.7419	49.1919	Yes	No	Yes	Yes	3	4
83	E2.I175	E2.V174	Shared	60.8614	54.5174	Yes	No	Yes	Yes	3	3
84	3x22	E2.V174	Shared	39.9384	46.7228	Yes	Yes	Yes	Yes	3	3
85	3x33	5x39	Shared	14.1286	15.4265	Yes	Yes	Yes	Yes	4	6
86	3x40	6x48	Shared	33.9479	30.1852	Yes	Yes	Yes	Yes	8	8
87	5x42	5x461	Shared	11.6492	10.5556	Yes	Yes	Yes	Yes	5	8
88	3x37	5x461	Shared	12.7169	13.5129	Yes	Yes	Yes	Yes	6	8
89	5x58	5x61	Shared	28.2772	60.0337	Yes	Yes	No	No	9	9
90	5x61	5x65	Shared	18.0077	56.9416	No	No	No	No	9	8
91	5x65	6x33	Shared	15.3003	38.4736	No	No	No	No	8	7
92	2x50	7x49	Shared	52.9553	59.1246	Yes	Yes	No	Yes	9	9
93	7x42	Lig	Shared	40.1984	43.5129	Yes	Yes	Yes	Yes	7	0
94	3x37	3x40	Shared	30.4007	24.7475	Yes	Yes	Yes	Yes	6	8
95	3x50	5x58	Shared	41.0941	43.0303	Yes	No	Yes	Yes	9	9
96	1x35	7x35	a1_on	3.01128	11.5769	Yes	Yes	No	Yes	5	3
97	1x35	1x36	a1_on	0	10.303	Yes	Yes	No	No	5	5
98	1x35	7x38	a1_on	9.46173	27.7273	Yes	Yes	No	Yes	5	5
99	1x50	2x51	a1_on	8.03407	31.1841	Yes	No	No	No	9	7
100	1x47	2x51	a1_on	5.36271	29.0123	No	No	No	No	6	7
101	1x47	1x48	a1_on	2.68336	26.8294	No	No	No	No	6	4
102	1x48	1x49	a1_on	0	24.6352	No	No	No	No	4	8
103	1x49	1x52	a1_on	2.63537	22.4299	No	No	No	No	8	7
104	1x52	8x54	a1_on	0	13.4961	No	No	No	No	7	7
105	2x40	8x50	a1_on	4.51092	47.5309	No	Yes	Yes	Yes	8	9
106	2x40	I1x50	a1_on	0.115972	10.1235	No	Yes	No	No	8	8
107	2x37	2x40	a1_on	0	35.202	No	No	No	Yes	7	8
108	2x37	2x39	a1_on	0	15.6229	No	No	No	No	7	8
109	2x37	I2x54	a1_on	1.27169	18.165	No	No	No	No	7	4
110	2x39	3x49	a1_on	3.7511	12.7497	No	No	No	No	8	9
111	6x51	7x38	a1_on	0	12.0595	No	Yes	No	Yes	6	5
112	6x51	7x41	a1_on	1.54763	18.1818	No	Yes	No	No	6	7
113	3x43	7x49	a1_on	0	76.532	No	No	No	Yes	8	9
114	3x22	3x26	a1_on	0.0479885	13.3895	Yes	Yes	No	No	3	5
115	3x23	3x26	a1_on	0	11.6442	No	No	No	No	1	5
116	3x22	E2.V152	a1_on	2.54739	22.5533	Yes	Yes	No	No	3	1
117	E2.P165	E2.V152	a1_on	0	20.9147	No	No	No	No	5	1
118	E2.E164	E2.P165	a1_on	5.52267	13.468	No	No	No	No	3	5
119	3x21	E2.E164	a1_on	2.76334	11.5769	No	No	No	No	6	3
120	3x43	7x53	a1_on	5.64265	94.422	No	No	Yes	Yes	8	9
121	3x50	7x53	a1_on	0.259938	44.2031	Yes	No	Yes	Yes	9	9
122	3x47	5x58	a1_on	1.45965	11.257	No	No	Yes	Yes	9	9
123	6x40	7x53	a1_on	8.61793	44.3603	Yes	No	Yes	Yes	8	9
124	5x58	6x40	a1_on	6.16252	42.8171	Yes	Yes	Yes	No	9	8
125	I2x53	I2x54	a1_on	2.54339	16.9529	Yes	Yes	No	No	7	4
126	3x52	I2x53	a1_on	0	15.0898	No	No	Yes	Yes	5	7
127	3x54	5x65	a1_on	0	20.1347	No	No	No	No	9	8
128	3x54	5x64	a1_on	2.77533	17.3232	No	No	No	No	9	5
129	3x55	5x64	a1_on	0	11.431	No	No	No	No	7	5
130	5x38	E2.W146	a1_on	4.51892	11.257	No	No	Yes	Yes	3	6
131	6x55	Lig	a1_on	4.94681	15.0112	No	No	Yes	Yes	5	0
132	5x37	6x55	a1_on	2.40742	13.2772	No	No	No	No	3	5
133	5x37	6x59	a1_on	0	10.2637	No	No	No	Yes	3	4
134	5x58	6x41	a1_on	4.32696	11.1785	Yes	Yes	No	No	9	8
135	5x69	6x33	a1_on	0	35.275	No	No	No	No	4	7
136	5x69	5x70	a1_on	0	31.8013	No	No	No	No	4	5
137	5x66	5x70	a1_on	1.43965	28.3109	No	No	No	No	5	5
138	5x62	5x66	a1_on	2.84332	21.2963	Yes	No	No	No	6	5
139	5x62	6x30	a1_on	5.68264	14.2368	Yes	No	No	No	6	6
140	6x27	6x30	a1_on	4.30297	10.7015	No	No	No	No	1	6
141	6x47	7x48	a1_on	0	11.532	No	No	No	No	8	6
142	6x51	7x37	a1_on	1.40766	16.2009	No	Yes	No	No	6	5
143	6x54	7x37	a1_on	0	14.4276	No	No	No	No	4	5
144	8x54	8x55	a1_on	0	11.4703	No	No	No	No	7	5
145	2x46	3x43	a1_on	6.6864	19.3996	Yes	Yes	No	No	9	8

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
1x35	1x39	Shared	17.96	14.59	1	1	2	2
1x35	7x38	Shared	8.46	6.04	1	1	2	1
1x39	2x57	Shared	8.2	9.56	1	1	2	2
1x39	7x42	Shared	12.31	14.77	1	1	2	1
2x56	7x42	Shared	4.15	4.15	0	0	2	1
2x57	7x42	Shared	6.63	3.98	1	1	2	1
2x60	7x42	Shared	4.39	4.39	0	0	2	1
3x32	Lig	Shared	6.87	6.87	0	0	1	0
3x33	4x60	Shared	3.28	3.28	1	1	1	2
3x33	E2x52	Shared	4.87	4.87	1	1	1	1
3x33	5x39	Shared	5.86	4.69	1	1	1	2
3x33	Lig	Shared	3.65	3.65	1	1	1	0
3x36	6x48	Shared	3.64	4.85	0	0	1	2
3x36	Lig	Shared	11.66	6.8	0	0	1	0
4x60	E2.I175	Shared	5.08	3.39	1	1	2	2
4x60	5x39	Shared	12.52	9.74	1	1	2	2
E2.I175	E2x52	Shared	11.3	7.54	0	1	2	1
E2x52	Lig	Shared	20.06	23.28	1	1	1	0
E2.E172	Lig	Shared	7.86	7.86	0	0	1	0
5x37	5x40	Shared	4.33	4.33	0	1	2	1
5x37	6x55	Shared	4.21	5.61	0	1	2	1
5x39	5x40	a1_on	4.79	0	1	1	2	1
5x40	5x43	Shared	7.01	5.61	0	1	1	2
6x48	7x41	Shared	6.06	8.49	2	1	2	1
6x51	7x37	Shared	3.15	3.15	1	1	1	2
6x51	7x38	a1_on	4.28	0	1	1	1	1
6x51	7x41	Shared	7.37	7.37	1	1	1	1
6x51	Lig	Shared	10.94	16.42	1	1	1	0
6x55	Lig	Shared	9.05	9.95	0	1	1	0
7x34	E3.K265	Shared	4.5	6.01	0	0	1	2
7x38	7x42	a1_on	3.98	0	1	0	1	1
7x38	Lig	Shared	6.58	4.7	1	0	1	0
7x42	Lig	Shared	6.78	10.17	1	1	1	0
3x29	E2x52	a1_on	2.77	0	0	0	2	1
E2.E172	E2x51	a1_on	2.54	0	0	0	1	2
2x63	E2x52	Shared	2.51	5.02	0	0	2	1
2x56	3x32	a1_on_allo	0	4.81	0	0	2	1
3x29	E2.I175	a1_on_allo	0	3.25	0	0	2	2
3x33	5x40	a1_on_allo	0	4.24	1	1	1	1
5x39	E2.I175	a1_on_allo	0	3.63	1	1	2	2
5x40	6x55	a1_on_allo	0	8.41	0	1	1	1
5x40	Lig	a1_on_allo	0	3.73	0	1	1	0
7x41	Lig	a1_on_allo	0	4.86	0	1	1	0
7x34	Lig	a1_on_allo	0	1.94	0	0	1	0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	a1_on_allo	7LD3-A₁-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
	a1_on	7LD4-A₁-Adenosine-Gi2/&β;1/&γ;2

Network Difference
Value	a1_on_allo	a1_on
I_min	3.07	3.07
Number of Linked Nodes	265	269
Number of Specific Nodes	6 (2.26%)	10 (3.72%)
Number of Shared Nodes	259 (97.74%)	259 (96.28%)
Number of Links	309	297
Number of Specific Links	87 (28.16%)	75 (25.25%)
Number of Shared Links	222 (71.84%)	222 (74.75%)
Number of Hubs	46	36
Number of Specific Hubs	18 (39.13%)	8 (22.22%)
Number of Shared Hubs	28 (60.87%)	28 (77.78%)
Average % Shared Neighbours (Jaccard)	58.87
Average % Shared Neighbours (Otsuka)	68.61
Average % Shared Neighbours (Overlap Coefficient)	79.09
Average % Shared Cliques (k3-6)	82.56
Graphlets Similarity	0.600879

Paths Difference
Value	a1_on_allo	a1_on
Number Of Nodes in MetaPath	90	86
Specific Nodes in MetaPath	41 (45.56%)	37 (43.02%)
Shared Nodes in MetaPath	259 (97.74%)	259 (97.74%)
Number Of Links MetaPath	95	87
Specific Links in MetaPath	58 (61.05%)	50 (57.47%)
Shared Links in MetaPath	222 (71.84%)	222 (71.84%)
Number of Shortest Paths	73228	49425
Length Of Smallest Path	3	3
Average Path Length	13.3392	13.6028
Length of Longest Path	30	33
Minimum Path Strength	1.24	1.4
Average Path Strength	6.47704	6.15623
Maximum Path Strength	19.85	17.04
Minimum Path Correlation	0.7	0.7
Average Path Correlation	0.923502	0.92871
Maximum Path Correlation	0.99	0.99
Minimum % Of Corr. Nodes	5	3.84615
Average % Of Corr. Nodes	50.0008	52.2151
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	49.1415	39.7394
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download a1_on_ortoallo.zip<

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