psnGPCR

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Orange: nodes, hubs and links specific of a2_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of a2_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	a2_off Int. Strength	a2_on Int. Strength	a2_off Hub1?	a2_on Hub1?	a2_off Hub2?	a2_on Hub2?	ConSurf1	ConSurf2
1	1x49	7x50	a2_off	100	0	No	No	No	No	9	9
2	1x52	8x54	a2_off	100	0	No	No	No	No	6	6
3	1x52	8x57	a2_off	100	0	No	No	No	No	6	6
4	1x53	7x50	a2_off	100	0	No	No	No	No	9	9
5	1x53	7x53	a2_off	100	0	No	No	Yes	Yes	9	9
6	1x55	1x59	a2_off	100	0	No	No	No	No	4	5
7	1x55	8x57	a2_off	100	0	No	No	No	No	4	6
8	1x56	8x53	a2_off	100	0	No	No	No	No	8	7
9	1x60	I1x49	a2_off	100	0	Yes	No	No	No	6	5
10	1x60	8x49	a2_off	100	0	Yes	No	Yes	No	6	6
11	8x49	I1x49	a2_off	100	0	Yes	No	No	No	6	5
12	2x38	I2x57	a2_off	100	0	No	No	Yes	No	6	7
13	2x38	4x42	a2_off	100	0	No	No	No	No	6	7
14	2x39	3x50	a2_off	100	0	No	No	Yes	No	8	9
15	2x40	2x43	a2_off	100	0	Yes	No	No	No	8	8
16	2x42	3x46	a2_off	100	0	Yes	Yes	No	No	7	8
17	2x43	7x53	a2_off	100	0	No	No	Yes	Yes	8	9
18	2x53	3x35	a2_off	100	0	No	No	No	No	6	7
19	2x53	7x46	a2_off	100	0	No	No	No	No	6	9
20	2x551	2x59	a2_off	100	0	No	No	No	No	5	5
21	2x551	3x31	a2_off	100	0	No	No	Yes	No	5	5
22	E1x50	E2x50	a2_off	100	0	Yes	No	No	No	7	9
23	3x33	5x43	a2_off	100	0	No	No	No	Yes	4	5
24	3x34	4x58	a2_off	100	0	No	No	No	No	4	3
25	3x36	6x48	a2_off	100	0	No	No	Yes	Yes	6	8
26	3x37	4x53	a2_off	100	0	Yes	Yes	No	No	5	7
27	3x39	6x44	a2_off	100	0	No	No	Yes	Yes	9	9
28	3x40	5x50	a2_off	100	0	No	No	No	No	7	8
29	3x40	6x44	a2_off	100	0	No	No	Yes	Yes	7	9
30	3x41	4x53	a2_off	100	0	Yes	No	No	No	5	7
31	3x44	5x54	a2_off	100	0	No	No	No	No	7	8
32	3x47	5x58	a2_off	100	0	No	No	No	Yes	9	9
33	3x49	3x50	a2_off	100	0	Yes	No	Yes	No	9	9
34	3x49	I2x57	a2_off	100	0	Yes	No	Yes	No	9	7
35	3x50	3x53	a2_off	100	0	Yes	No	No	No	9	8
36	3x50	I2x53	a2_off	100	0	Yes	No	Yes	Yes	9	7
37	3x51	5x61	a2_off	100	0	No	No	No	No	8	9
38	3x52	I2x53	a2_off	100	0	No	No	Yes	Yes	5	7
39	3x54	6x30	a2_off	100	0	Yes	No	No	Yes	8	7
40	5x36	5x38	a2_off	100	0	No	No	No	No	4	4
41	5x37	6x59	a2_off	100	0	No	No	Yes	No	4	3
42	5x39	5x40	a2_off	100	0	Yes	Yes	Yes	Yes	6	6
43	5x39	5x43	a2_off	100	0	Yes	Yes	No	Yes	6	5
44	5x41	5x45	a2_off	100	0	No	No	Yes	No	5	4
45	5x411	6x59	a2_off	100	0	No	No	Yes	No	5	3
46	5x42	5x461	a2_off	100	0	Yes	Yes	Yes	No	4	5
47	5x45	6x60	a2_off	100	0	Yes	No	Yes	No	4	6
48	5x58	6x38	a2_off	100	0	No	Yes	No	No	9	5
49	5x62	6x35	a2_off	100	0	No	Yes	No	No	5	7
50	5x68	6x27	a2_off	100	0	No	No	No	No	6	4
51	5x69	6x27	a2_off	100	0	No	Yes	No	No	5	4
52	6x32	7x56	a2_off	100	0	No	No	Yes	No	8	7
53	6x40	7x49	a2_off	100	0	No	No	No	Yes	8	9
54	6x40	7x52	a2_off	100	0	No	No	No	No	8	8
55	6x44	7x45	a2_off	100	0	Yes	Yes	No	No	9	9
56	7x34	E3	a2_off	100	0	No	No	Yes	Yes	4	2
57	7x32	7x33	a2_off	100	0	No	No	Yes	No	1	4
58	7x49	7x53	a2_off	100	0	No	Yes	Yes	Yes	9	9
59	7x53	8x50	a2_off	100	0	Yes	Yes	Yes	Yes	9	8
60	8x50	8x54	a2_off	100	0	Yes	Yes	No	No	8	6
61	8x55	8x59	a2_off	100	0	No	No	No	No	5	5
62	3x27	4x58	a2_off	100	0	No	No	No	No	4	3
63	5x37	E2	a2_off	100	0	No	No	Yes	Yes	4	3
64	E2	E3	a2_off	100	0	Yes	Yes	Yes	Yes	3	2
65	5x411	5x45	a2_off	100	0	No	No	Yes	No	5	4
66	7x31	7x35	a2_off	100	0	No	No	No	No	3	3
67	8x48	8x52	a2_off	100	0	No	No	No	No	4	4
68	1x27	1x30	a2_off	100	0	No	No	No	No	0	0
69	2x50	Na1	a2_off	100	0	No	Yes	No	No	9	0
70	3x39	Na1	a2_off	100	0	No	No	No	No	9	0
71	E3	Lig	a2_off	100	0	Yes	Yes	Yes	Yes	2	0
72	1x47	2x54	a2_off	80.7692	0	No	No	No	No	6	7
73	6x47	7x40	a2_off	46.1538	0	No	No	No	No	8	7
74	2x63	E2x50	a2_off	61.5385	0	No	No	No	No	4	9
75	I2x56	I2x57	a2_off	53.8462	0	No	No	Yes	No	4	7
76	2x54	2x57	a2_off	46.1538	0	No	No	Yes	Yes	7	6
77	3x47	5x57	a2_off	53.8462	0	No	No	No	No	9	7
78	2x66	E2x51	a2_off	61.5385	0	No	No	No	No	4	4
79	6x25	6x29	a2_off	57.6923	0	No	No	No	No	4	6
80	5x69	6x24	a2_off	11.5385	0	No	Yes	Yes	No	5	3
81	1x42	7x39	a2_off	26.9231	0	No	No	No	No	7	5
82	3x43	5x54	a2_off	3.84615	0	No	Yes	No	No	8	8
83	3x46	6x37	a2_off	26.9231	0	No	No	No	No	8	8
84	7x54	8x54	a2_off	0	0	No	No	No	No	7	6
85	1x44	1x48	a2_off	3.84615	0	No	No	No	No	4	5
86	6x43	7x52	a2_off	0	0	No	No	No	No	7	8
87	1x55	8x61	a2_off	30.7692	0	No	No	No	No	4	0
88	6x35	7x56	a2_off	15.3846	0	No	No	Yes	No	7	7
89	6x54	7x33	a2_off	7.69231	0	No	No	Yes	No	5	4
90	3x43	6x41	a2_off	26.9231	0	No	Yes	No	No	8	8
91	5x51	5x54	a2_off	3.84615	0	No	No	No	No	6	8
92	6x53	6x57	a2_off	0	0	No	No	No	No	5	4
93	5x56	5x59	a2_off	30.7692	0	No	No	No	No	4	4
94	5x44	6x49	a2_off	0	0	Yes	Yes	No	No	5	6
95	2x41	4x39	a2_off	3.84615	0	No	No	No	No	5	1
96	4x63	E2	a2_off	26.9231	0	No	No	Yes	Yes	4	3
97	1x58	1x59	a2_off	11.5385	0	No	No	No	No	3	5
98	5x49	5x53	a2_off	3.84615	0	No	No	No	No	5	6
99	2x38	4x39	a2_off	7.69231	0	No	No	No	No	6	1
100	3x54	5x68	a2_off	19.2308	0	Yes	No	No	No	8	6
101	6x49	6x53	a2_off	11.5385	0	No	No	No	No	6	5
102	5x65	6x31	a2_off	7.69231	0	No	No	No	No	8	5
103	7x47	7x51	a2_off	0	0	No	No	No	No	7	6
104	6x21	6x24	a2_off	19.2308	0	No	No	Yes	No	4	3
105	5x63	5x66	a2_off	15.3846	0	No	No	No	No	4	5
106	1x32	1x36	a2_off	0	0	No	No	No	No	0	6
107	1x30	1x31	a2_off	0	0	No	No	No	No	0	0
108	6x26	6x30	a2_off	3.84615	0	No	No	No	Yes	5	7
109	1x29	1x33	a2_off	0	0	No	No	No	No	0	4
110	5x46	5x461	a2_off	0	0	No	No	Yes	No	3	5
111	7x33	7x36	a2_off	0	0	Yes	No	No	No	4	5
112	8x49	8x52	a2_off	11.5385	0	Yes	No	No	No	6	4
113	1x27	1x28	a2_off	0	0	No	No	No	No	0	0
114	1x52	8x58	a2_off	0	0	No	No	No	No	6	6
115	5x67	6x27	a2_off	7.69231	0	No	No	No	No	4	4
116	4x59	4x62	a2_off	7.69231	0	Yes	No	No	No	6	4
117	6x43	6x46	a2_off	0	0	No	No	No	No	7	5
118	5x62	5x66	a2_off	11.5385	0	No	Yes	No	No	5	5
119	I2x51	I2x52	a2_off	7.69231	0	No	No	No	No	6	5
120	2x41	4x43	a2_off	11.5385	0	No	No	No	No	5	3
121	5x72	I3	a2_off	7.69231	0	No	No	No	No	4	2
122	8x58	8x62	a2_off	7.69231	0	No	No	No	No	6	0
123	5x72	6x24	a2_off	7.69231	0	No	No	Yes	No	4	3
124	3x50	6x33	a2_off	7.69231	0	Yes	No	No	No	9	8
125	6x21	6x22	a2_off	7.69231	0	No	No	No	No	4	1
126	6x26	6x29	a2_off	3.84615	0	No	No	No	No	5	6
127	8x58	8x63	a2_off	0	0	No	No	No	No	6	0
128	5x59	5x60	a2_off	3.84615	0	No	No	No	No	4	5
129	1x59	8x56	a2_off	3.84615	0	No	No	No	No	5	4
130	5x70	5x73	a2_off	0	0	No	No	No	No	5	2
131	6x23	6x26	a2_off	3.84615	0	No	No	No	No	3	5
132	1x37	1x38	a2_off	3.84615	0	No	No	No	No	4	5
133	8x59	8x64	a2_off	3.84615	0	No	No	No	No	5	0
134	I2x54	I2x55	a2_off	3.84615	0	No	No	No	No	5	5
135	3x23	3x24	a2_off	0	0	No	No	No	No	2	6
136	2x48	4x50	a2_off	0	0	No	No	Yes	No	7	9
137	1x35	1x39	Shared	100	100	No	Yes	Yes	Yes	5	6
138	1x35	7x35	Shared	100	100	No	Yes	No	No	5	3
139	1x36	2x61	Shared	100	100	No	No	No	No	6	6
140	1x39	2x57	Shared	100	100	Yes	Yes	Yes	Yes	6	6
141	1x39	2x61	Shared	100	100	Yes	Yes	No	No	6	6
142	1x39	7x39	Shared	100	100	Yes	Yes	No	No	6	5
143	1x39	7x42	Shared	100	100	Yes	Yes	Yes	Yes	6	6
144	1x43	2x57	Shared	100	100	No	No	Yes	Yes	6	6
145	1x45	7x47	Shared	100	25	No	No	No	No	5	7
146	1x50	2x47	Shared	100	100	Yes	Yes	No	No	9	9
147	1x50	2x50	Shared	100	100	Yes	Yes	No	Yes	9	9
148	1x50	7x50	Shared	100	100	Yes	Yes	No	No	9	9
149	1x51	2x51	Shared	100	0	No	No	No	No	4	7
150	1x60	I1x50	Shared	100	100	Yes	No	Yes	Yes	6	8
151	1x60	8x53	Shared	100	100	Yes	No	No	No	6	7
152	2x40	I1x50	Shared	100	100	Yes	No	Yes	Yes	8	8
153	8x49	I1x50	Shared	100	100	Yes	No	Yes	Yes	6	8
154	8x50	I1x50	Shared	100	100	Yes	Yes	Yes	Yes	8	8
155	8x53	I1x50	Shared	100	100	No	No	Yes	Yes	7	8
156	2x37	2x39	Shared	100	50	No	No	No	No	7	8
157	2x37	2x40	Shared	100	100	No	No	Yes	No	7	8
158	2x39	3x49	Shared	100	100	No	No	Yes	No	8	9
159	2x40	8x50	Shared	100	100	Yes	No	Yes	Yes	8	8
160	2x42	3x45	Shared	100	100	Yes	Yes	No	No	7	7
161	2x42	4x45	Shared	100	25	Yes	Yes	No	No	7	5
162	2x42	4x46	Shared	100	100	Yes	Yes	No	No	7	8
163	2x45	3x42	Shared	100	100	No	No	No	No	9	7
164	2x45	4x46	Shared	100	100	No	No	No	No	9	8
165	2x45	4x50	Shared	100	100	No	No	Yes	No	9	9
166	2x46	7x49	Shared	100	100	No	Yes	No	Yes	9	9
167	2x50	7x46	Shared	100	100	No	Yes	No	No	9	9
168	2x52	3x35	Shared	100	25	No	No	No	No	6	7
169	2x53	2x56	Shared	100	100	No	No	No	No	6	6
170	2x57	2x58	Shared	100	100	Yes	Yes	No	No	6	8
171	2x57	7x42	Shared	100	100	Yes	Yes	Yes	Yes	6	6
172	2x59	3x28	Shared	100	100	No	No	No	No	5	6
173	2x59	3x31	Shared	100	100	No	No	Yes	No	5	5
174	2x62	E1x50	Shared	100	25	No	No	Yes	No	5	7
175	E1x50	E1x52	Shared	100	50	Yes	No	No	No	7	6
176	E1x51	E2	Shared	100	25	No	No	Yes	Yes	2	3
177	3x22	E2	Shared	100	100	No	No	Yes	Yes	3	3
178	3x25	E2x50	Shared	100	100	No	No	No	No	9	9
179	3x25	E2	Shared	100	100	No	No	Yes	Yes	9	3
180	3x26	E2	Shared	100	100	No	No	Yes	Yes	6	3
181	3x27	3x31	Shared	100	100	No	No	Yes	No	4	5
182	3x27	4x61	Shared	100	100	No	No	No	Yes	4	5
183	3x30	4x60	Shared	100	100	No	No	No	Yes	5	5
184	3x31	3x35	Shared	100	100	Yes	No	No	No	5	7
185	3x33	5x39	Shared	100	100	No	No	Yes	Yes	4	6
186	3x34	4x54	Shared	100	100	No	No	No	No	4	3
187	3x37	3x40	Shared	100	100	Yes	Yes	No	No	5	7
188	3x37	3x41	Shared	100	100	Yes	Yes	Yes	No	5	5
189	3x37	4x56	Shared	100	100	Yes	Yes	No	Yes	5	4
190	3x37	5x461	Shared	100	100	Yes	Yes	Yes	No	5	5
191	3x38	4x50	Shared	100	100	No	No	Yes	No	6	9
192	3x38	4x53	Shared	100	50	No	No	No	No	6	7
193	3x41	4x49	Shared	100	100	Yes	No	No	No	5	7
194	3x43	6x44	Shared	100	100	No	Yes	Yes	Yes	8	9
195	3x44	3x48	Shared	100	0	No	No	No	No	7	6
196	3x49	I2x53	Shared	100	100	Yes	No	Yes	Yes	9	7
197	3x51	3x55	Shared	100	100	No	No	No	No	8	6
198	3x51	5x60	Shared	100	100	No	No	No	No	8	5
199	3x52	I2x57	Shared	100	0	No	No	Yes	No	5	7
200	3x53	I2x53	Shared	100	100	No	No	Yes	Yes	8	7
201	3x56	I2x52	Shared	100	50	No	No	No	No	5	5
202	I2x53	I2x54	Shared	100	25	Yes	Yes	No	No	7	5
203	I2x53	I2x57	Shared	100	100	Yes	Yes	Yes	No	7	7
204	4x38	4x41	Shared	100	100	No	No	No	No	7	5
205	4x56	5x461	Shared	100	100	No	Yes	Yes	No	4	5
206	4x58	4x61	Shared	100	50	No	No	No	Yes	3	5
207	4x59	4x60	Shared	100	100	Yes	No	No	Yes	6	5
208	4x59	5x39	Shared	100	100	Yes	No	Yes	Yes	6	6
209	4x59	5x42	Shared	100	100	Yes	No	Yes	Yes	6	4
210	4x60	5x39	Shared	100	100	No	Yes	Yes	Yes	5	6
211	5x36	E2	Shared	100	100	No	No	Yes	Yes	4	3
212	5x38	E2	Shared	100	50	No	No	Yes	Yes	4	3
213	5x39	E2	Shared	100	100	Yes	Yes	Yes	Yes	6	3
214	E2	E2	Shared	100	100	Yes	Yes	Yes	Yes	3	3
215	E2	E2x51	Shared	100	100	Yes	Yes	No	No	3	4
216	E2	E2x52	Shared	100	100	Yes	Yes	Yes	Yes	3	4
217	5x40	E2x52	Shared	100	100	Yes	Yes	Yes	Yes	6	4
218	E2x52	Lig	Shared	100	100	Yes	Yes	Yes	Yes	4	0
219	5x37	6x55	Shared	100	100	No	No	No	No	4	5
220	5x39	5x42	Shared	100	100	Yes	Yes	Yes	Yes	6	4
221	5x40	Lig	Shared	100	100	Yes	Yes	Yes	Yes	6	0
222	5x41	6x59	Shared	100	100	No	No	Yes	No	5	3
223	5x411	6x60	Shared	100	100	No	No	Yes	No	5	6
224	5x44	5x45	Shared	100	100	Yes	Yes	Yes	No	5	4
225	5x44	5x47	Shared	100	100	Yes	Yes	No	No	5	7
226	5x44	6x52	Shared	100	100	Yes	Yes	Yes	Yes	5	6
227	5x47	6x52	Shared	100	100	No	No	Yes	Yes	7	6
228	5x49	5x50	Shared	100	100	No	No	No	No	5	8
229	5x58	6x37	Shared	100	25	No	Yes	No	No	9	8
230	6x24	6x28	Shared	100	25	Yes	No	No	No	3	4
231	6x36	7x56	Shared	100	100	No	No	Yes	No	8	7
232	6x39	7x56	Shared	100	100	No	No	Yes	No	6	7
233	6x40	7x53	Shared	100	100	No	No	Yes	Yes	8	9
234	6x44	6x48	Shared	100	100	Yes	Yes	Yes	Yes	9	8
235	6x47	7x45	Shared	100	100	No	No	No	No	8	9
236	6x48	7x41	Shared	100	100	Yes	Yes	No	No	8	7
237	6x50	7x40	Shared	100	0	No	No	No	No	9	7
238	6x51	Lig	Shared	100	100	No	No	Yes	Yes	5	0
239	6x54	7x34	Shared	100	50	No	No	No	No	5	4
240	6x55	Lig	Shared	100	100	No	No	Yes	Yes	5	0
241	6x56	6x60	Shared	100	100	No	No	Yes	No	6	6
242	6x58	E3	Shared	100	25	No	No	Yes	Yes	4	2
243	6x59	6x60	Shared	100	100	Yes	No	Yes	No	3	6
244	6x61	E3	Shared	100	100	No	No	Yes	Yes	4	2
245	7x30	7x32	Shared	100	50	No	No	No	No	3	1
246	7x30	7x33	Shared	100	25	No	No	Yes	No	3	4
247	7x34	Lig	Shared	100	100	No	No	Yes	Yes	4	0
248	7x38	7x42	Shared	100	100	No	No	Yes	Yes	4	6
249	7x38	Lig	Shared	100	100	No	No	Yes	Yes	4	0
250	8x47	8x50	Shared	100	100	No	No	Yes	Yes	8	8
251	8x48	8x51	Shared	100	25	No	No	No	No	4	8
252	1x35	2x64	Shared	100	100	No	Yes	No	No	5	3
253	1x57	2x44	Shared	100	100	No	No	No	No	7	5
254	3x23	E2	Shared	100	50	No	No	Yes	Yes	2	3
255	3x33	5x40	Shared	100	100	No	No	Yes	Yes	4	6
256	5x42	E2	Shared	100	100	Yes	Yes	Yes	Yes	4	3
257	E2	Lig	Shared	100	100	Yes	Yes	Yes	Yes	3	0
258	5x43	6x52	Shared	100	100	No	Yes	Yes	Yes	5	6
259	5x44	5x48	Shared	100	100	Yes	Yes	No	No	5	4
260	6x31	6x35	Shared	100	0	No	No	No	No	5	7
261	6x48	Lig	Shared	100	100	Yes	Yes	Yes	Yes	8	0
262	6x52	Lig	Shared	100	100	Yes	Yes	Yes	Yes	6	0
263	8x51	8x55	Shared	100	0	No	No	No	No	8	5
264	2x65	E1x50	Shared	80.7692	100	No	No	Yes	No	5	7
265	1x38	7x39	Shared	42.3077	100	No	No	No	No	5	5
266	2x55	2x551	Shared	38.4615	100	No	No	No	No	5	5
267	4x56	4x57	Shared	73.0769	50	No	Yes	No	No	4	6
268	3x54	5x61	Shared	30.7692	100	Yes	No	No	No	8	9
269	2x56	3x32	Shared	61.5385	50	No	No	No	No	6	6
270	6x51	7x37	Shared	23.0769	50	No	No	No	No	5	6
271	1x50	2x51	Shared	7.69231	0	Yes	Yes	No	No	9	7
272	3x29	E2x52	Shared	3.84615	100	No	No	Yes	Yes	5	4
273	6x43	7x48	Shared	38.4615	100	No	No	No	No	7	6
274	5x57	5x61	Shared	7.69231	25	No	No	No	No	7	9
275	2x60	7x42	Shared	0	25	No	No	Yes	Yes	5	6
276	3x41	4x52	Shared	30.7692	25	Yes	No	No	No	5	4
277	1x36	1x40	Shared	0	50	No	No	No	No	6	5
278	I1x48	I1x51	Shared	19.2308	100	No	No	No	No	5	7
279	6x39	7x52	Shared	19.2308	25	No	No	No	No	6	8
280	1x42	7x43	Shared	0	25	No	No	No	No	7	5
281	2x49	4x50	Shared	0	0	No	No	Yes	No	8	9
282	4x48	4x52	Shared	0	25	No	No	No	No	3	4
283	1x57	8x50	Shared	0	100	No	No	Yes	Yes	7	8
284	5x55	5x59	Shared	38.4615	25	No	No	No	No	4	4
285	5x62	6x34	Shared	0	100	No	Yes	No	No	5	7
286	5x48	5x52	Shared	38.4615	25	No	No	No	No	4	3
287	3x52	3x56	Shared	0	25	No	No	No	No	5	5
288	8x60	8x61	Shared	23.0769	100	No	No	No	No	4	0
289	2x41	I1x51	Shared	30.7692	0	No	No	No	No	5	7
290	6x45	6x49	Shared	7.69231	0	No	No	No	No	5	6
291	4x38	4x39	Shared	7.69231	25	No	No	No	No	7	1
292	1x54	2x44	Shared	7.69231	50	No	No	No	No	7	5
293	1x46	7x46	Shared	3.84615	100	No	No	No	No	7	9
294	1x48	1x49	Shared	0	0	No	No	No	No	5	9
295	1x46	7x47	Shared	0	25	No	No	No	No	7	7
296	3x56	I2x50	Shared	0	0	No	No	No	No	5	8
297	7x51	7x55	Shared	3.84615	100	No	No	No	Yes	6	6
298	4x38	4x40	Shared	0	0	No	No	No	No	7	5
299	1x34	1x38	Shared	0	100	No	No	No	No	5	5
300	3x54	5x64	Shared	0	0	Yes	No	No	No	8	6
301	1x29	1x30	Shared	0	25	No	No	No	No	0	0
302	6x42	6x45	Shared	0	0	No	No	No	No	5	5
303	4x44	4x47	Shared	0	0	No	No	No	No	3	4
304	4x43	4x44	Shared	0	0	No	No	No	No	3	3
305	1x29	1x32	Shared	0	100	No	No	No	No	0	0
306	5x68	5x71	Shared	0	25	No	No	No	No	6	3
307	5x66	5x70	Shared	0	50	No	No	No	No	5	5
308	1x31	7x31	a2_on	0	100	No	No	No	No	0	3
309	1x31	7x32	a2_on	0	100	No	No	No	No	0	1
310	1x32	7x31	a2_on	0	100	No	No	No	No	0	3
311	1x35	7x38	a2_on	0	100	No	Yes	No	No	5	4
312	1x46	1x50	a2_on	0	100	No	No	Yes	Yes	7	9
313	1x47	2x55	a2_on	0	100	No	No	No	No	6	5
314	1x53	7x54	a2_on	0	100	No	No	No	No	9	7
315	1x53	7x55	a2_on	0	100	No	No	No	Yes	9	6
316	1x56	8x54	a2_on	0	100	No	No	No	No	8	6
317	2x37	2x38	a2_on	0	100	No	No	No	No	7	6
318	2x39	I2x53	a2_on	0	100	No	No	Yes	Yes	8	7
319	2x42	3x49	a2_on	0	100	Yes	Yes	Yes	No	7	9
320	2x42	4x42	a2_on	0	100	Yes	Yes	No	No	7	7
321	2x46	2x50	a2_on	0	100	No	Yes	No	Yes	9	9
322	2x46	3x42	a2_on	0	100	No	Yes	No	No	9	7
323	2x46	3x43	a2_on	0	100	No	Yes	No	Yes	9	8
324	2x50	7x49	a2_on	0	100	No	Yes	No	Yes	9	9
325	2x53	2x54	a2_on	0	100	No	No	No	No	6	7
326	2x63	3x28	a2_on	0	100	No	No	No	No	4	6
327	3x21	E1x52	a2_on	0	100	No	No	No	No	7	6
328	3x21	3x24	a2_on	0	100	No	No	No	No	7	6
329	3x26	3x30	a2_on	0	100	No	No	No	No	6	5
330	3x26	4x61	a2_on	0	100	No	No	No	Yes	6	5
331	3x30	4x61	a2_on	0	100	No	No	No	Yes	5	5
332	3x33	E2x52	a2_on	0	100	No	No	Yes	Yes	4	4
333	3x36	Lig	a2_on	0	100	No	No	Yes	Yes	6	0
334	3x37	5x43	a2_on	0	100	Yes	Yes	No	Yes	5	5
335	3x40	6x48	a2_on	0	100	No	No	Yes	Yes	7	8
336	3x43	7x49	a2_on	0	100	No	Yes	No	Yes	8	9
337	3x43	7x53	a2_on	0	100	No	Yes	Yes	Yes	8	9
338	3x44	5x50	a2_on	0	100	No	No	No	No	7	8
339	3x44	5x53	a2_on	0	100	No	No	No	No	7	6
340	3x46	7x53	a2_on	0	100	No	No	Yes	Yes	8	9
341	3x47	5x54	a2_on	0	100	No	No	No	No	9	8
342	3x50	7x53	a2_on	0	100	Yes	No	Yes	Yes	9	9
343	3x51	5x57	a2_on	0	100	No	No	No	No	8	7
344	I2x52	I2x56	a2_on	0	100	No	No	No	No	5	4
345	4x40	4x43	a2_on	0	100	No	No	No	No	5	3
346	4x56	5x42	a2_on	0	100	No	Yes	Yes	Yes	4	4
347	5x40	6x55	a2_on	0	100	Yes	Yes	No	No	6	5
348	5x41	6x56	a2_on	0	100	No	No	No	No	5	6
349	5x51	6x44	a2_on	0	100	No	No	Yes	Yes	6	9
350	5x54	5x58	a2_on	0	100	No	No	No	Yes	8	9
351	5x54	6x44	a2_on	0	100	No	No	Yes	Yes	8	9
352	5x58	6x40	a2_on	0	100	No	Yes	No	No	9	8
353	5x58	6x41	a2_on	0	100	No	Yes	No	No	9	8
354	5x61	6x37	a2_on	0	100	No	No	No	No	9	8
355	5x66	6x30	a2_on	0	100	No	No	No	Yes	5	7
356	5x69	6x29	a2_on	0	100	No	Yes	No	No	5	6
357	6x25	6x28	a2_on	0	100	No	No	No	No	4	4
358	6x48	7x45	a2_on	0	100	Yes	Yes	No	No	8	9
359	6x51	7x41	a2_on	0	100	No	No	No	No	5	7
360	E3	E3	a2_on	0	100	Yes	Yes	Yes	Yes	2	2
361	7x30	E3	a2_on	0	100	No	No	Yes	Yes	3	2
362	7x32	7x36	a2_on	0	100	No	No	No	No	1	5
363	7x42	Lig	a2_on	0	100	Yes	Yes	Yes	Yes	6	0
364	7x45	7x49	a2_on	0	100	No	No	No	Yes	9	9
365	7x52	7x53	a2_on	0	100	No	No	Yes	Yes	8	9
366	7x54	8x50	a2_on	0	100	No	No	Yes	Yes	7	8
367	7x55	8x54	a2_on	0	100	No	Yes	No	No	6	6
368	8x47	8x49	a2_on	0	100	No	No	Yes	No	8	6
369	8x49	8x50	a2_on	0	100	Yes	No	Yes	Yes	6	8
370	1x35	7x39	a2_on	0	100	No	Yes	No	No	5	5
371	2x64	Lig	a2_on	0	100	No	No	Yes	Yes	3	0
372	4x60	E2	a2_on	0	100	No	Yes	Yes	Yes	5	3
373	5x40	5x43	a2_on	0	100	Yes	Yes	No	Yes	6	5
374	5x43	Lig	a2_on	0	100	No	Yes	Yes	Yes	5	0
375	5x69	5x73	a2_on	0	100	No	Yes	No	No	5	2
376	5x73	6x26	a2_on	0	100	No	No	No	No	2	5
377	2x43	8x50	a2_on	0	25	No	No	Yes	Yes	8	8
378	5x69	6x30	a2_on	0	25	No	Yes	No	Yes	5	7
379	2x50	3x39	a2_on	0	50	No	Yes	No	No	9	9
380	5x53	5x57	a2_on	0	50	No	No	No	No	6	7
381	5x44	6x56	a2_on	0	50	Yes	Yes	No	No	5	6
382	2x56	3x35	a2_on	0	25	No	No	No	No	6	7
383	8x53	8x57	a2_on	0	50	No	No	No	No	7	6
384	6x27	6x30	a2_on	0	50	No	No	No	Yes	4	7
385	5x62	6x30	a2_on	0	25	No	Yes	No	Yes	5	7
386	I1x49	I1x50	a2_on	0	25	No	No	Yes	Yes	5	8
387	6x57	6x61	a2_on	0	25	No	No	No	No	4	4
388	5x62	6x37	a2_on	0	25	No	Yes	No	No	5	8
389	8x52	8x56	a2_on	0	25	No	No	No	No	4	4
390	1x52	7x55	a2_on	0	0	No	No	No	Yes	6	6
391	3x34	4x57	a2_on	0	25	No	No	No	No	4	6
392	3x48	3x52	a2_on	0	25	No	No	No	No	6	5
393	5x55	6x41	a2_on	0	25	No	No	No	No	4	8
394	7x36	7x40	a2_on	0	25	No	No	No	No	5	7
395	E1x52	E2x50	a2_on	0	0	No	No	No	No	6	9
396	5x67	5x70	a2_on	0	25	No	No	No	No	4	5
397	2x41	4x42	a2_on	0	25	No	No	No	No	5	7
398	4x39	4x42	a2_on	0	0	No	No	No	No	1	7
399	6x54	E3	a2_on	0	25	No	No	Yes	Yes	5	2
400	5x56	5x60	a2_on	0	25	No	No	No	No	4	5
401	I2x55	I2x56	a2_on	0	25	No	No	No	No	5	4
402	6x43	6x47	a2_on	0	0	No	No	No	No	7	8
403	6x49	6x50	a2_on	0	0	No	No	No	No	6	9
404	5x67	5x71	a2_on	0	25	No	No	No	No	4	3
405	5x46	5x49	a2_on	0	25	No	No	No	No	3	5
406	5x62	5x63	a2_on	0	25	No	Yes	No	No	5	4
407	2x51	2x55	a2_on	0	0	No	No	No	No	7	5
408	1x41	1x45	a2_on	0	25	No	No	No	No	5	5
409	5x69	5x72	a2_on	0	25	No	Yes	No	No	5	4
410	1x49	7x55	a2_on	0	0	No	No	No	Yes	9	6
411	2x65	NT	a2_on	0	25	No	No	No	No	5	0
412	1x57	1x58	a2_on	0	25	No	No	No	No	7	3
413	6x30	6x31	a2_on	0	25	No	Yes	No	No	7	5
414	2x66	E2	a2_on	0	0	No	No	Yes	Yes	4	3
415	1x47	1x51	a2_on	0	0	No	No	No	No	6	4
416	6x25	6x26	a2_on	0	25	No	No	No	No	4	5
417	4x54	4x55	a2_on	0	0	No	No	No	No	3	4
418	1x42	2x57	a2_on	0	25	No	No	Yes	Yes	7	6
419	6x32	6x36	a2_on	0	25	No	No	No	No	8	8
420	6x46	7x40	a2_on	0	0	No	No	No	No	5	7
421	8x56	8x60	a2_on	0	25	No	No	No	No	4	4
422	4x61	4x62	a2_on	0	25	No	Yes	No	No	5	4
423	6x29	I3	a2_on	0	25	No	No	No	No	6	2
424	8x57	8x61	a2_on	0	0	No	No	No	No	6	0
425	1x59	8x57	a2_on	0	0	No	No	No	No	5	6
426	8x55	8x58	a2_on	0	0	No	No	No	No	5	6
427	8x47	8x48	a2_on	0	0	No	No	No	No	8	4
428	4x62	4x63	a2_on	0	0	No	No	No	No	4	4
429	1x33	NT	a2_on	0	0	No	No	No	No	4	0
430	5x62	6x33	a2_on	0	0	No	Yes	No	No	5	8

Orange: nodes, hubs and links specific of a2_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of a2_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	a2_off Avg Int. Strength	a2_on Avg Int. Strength	a2_off Num Of Links	a2_on Num Of Links	ConSurf
1	1x60	a2_off	100	0	4	2	6
2	2x40	a2_off	65.3846	50	4	3	8
3	E1x50	a2_off	69.2308	0	4	3	7
4	3x31	a2_off	73.0769	0	4	3	5
5	3x41	a2_off	11.5385	0	4	3	5
6	3x49	a2_off	80.7692	25	4	3	9
7	3x50	a2_off	57.6923	25	5	1	9
8	3x54	a2_off	0	0	4	2	8
9	I2x57	a2_off	65.3846	0	5	2	7
10	4x50	a2_off	0	0	4	3	9
11	4x59	a2_off	3.84615	0	4	3	6
12	5x45	a2_off	76.9231	25	4	1	4
13	5x461	a2_off	0	0	4	2	5
14	6x24	a2_off	0	0	4	1	3
15	6x59	a2_off	96.1538	25	4	2	3
16	6x60	a2_off	80.7692	50	4	3	6
17	7x33	a2_off	3.84615	0	4	1	4
18	7x56	a2_off	15.3846	0	4	2	7
19	8x49	a2_off	15.3846	25	4	3	6
20	1x39	Shared	96.1538	75	5	5	6
21	1x50	Shared	3.84615	50	4	5	9
22	I1x50	Shared	96.1538	75	5	6	8
23	2x42	Shared	46.1538	50	4	5	7
24	2x57	Shared	88.4615	100	5	5	6
25	3x37	Shared	100	75	5	5	5
26	I2x53	Shared	88.4615	100	6	5	7
27	E2	Shared	100	100	17	16	3
28	E2x52	Shared	7.69231	50	4	5	4
29	5x39	Shared	100	100	7	5	6
30	5x40	Shared	61.5385	75	4	5	6
31	5x42	Shared	11.5385	0	4	4	4
32	5x44	Shared	42.3077	100	5	5	5
33	6x44	Shared	100	50	5	4	9
34	6x48	Shared	76.9231	100	4	5	8
35	6x52	Shared	69.2308	50	4	4	6
36	E3	Shared	76.9231	75	5	6	2
37	7x42	Shared	34.6154	75	4	5	6
38	7x53	Shared	100	75	5	5	9
39	8x50	Shared	100	75	6	7	8
40	Lig	Shared	100	100	10	13	0
41	1x35	a2_on	50	75	3	5	5
42	2x46	a2_on	3.84615	75	1	4	9
43	2x50	a2_on	23.0769	100	3	5	9
44	3x43	a2_on	0	25	3	4	8
45	4x56	a2_on	11.5385	25	3	4	4
46	4x60	a2_on	23.0769	50	3	4	5
47	4x61	a2_on	0	50	2	5	5
48	5x43	a2_on	26.9231	25	3	4	5
49	5x58	a2_on	7.69231	100	3	4	9
50	5x62	a2_on	0	0	3	5	5
51	5x69	a2_on	0	25	2	4	5
52	6x30	a2_on	0	0	2	5	7
53	7x49	a2_on	23.0769	75	3	4	9
54	7x55	a2_on	0	25	1	5	6

Orange: nodes, hubs and links specific of a2_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of a2_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	a2_off Recurrence	a2_on Recurrence	a2_off Hub1?	a2_on Hub1?	a2_off Hub2?	a2_on Hub2?	ConSurf1	ConSurf2
1	1x39	2x61	a2_off	12.7023	4.20723	Yes	Yes	No	No	6	6
2	1x36	2x61	a2_off	11.4453	2.81178	No	No	No	No	6	6
3	1x39	7x42	a2_off	25.5533	9.44642	Yes	Yes	Yes	Yes	6	6
4	7x38	7x42	a2_off	33.8222	0.0543138	No	No	Yes	Yes	4	6
5	7x38	Lig	a2_off	34.8528	7.72927	No	No	Yes	Yes	4	0
6	3x39	6x44	a2_off	100	0	No	No	Yes	Yes	9	9
7	3x39	Na1	a2_off	99.9696	0	No	No	No	No	9	0
8	2x50	Na1	a2_off	99.973	0	No	Yes	No	No	9	0
9	2x50	7x46	a2_off	23.0291	8.26405	No	Yes	No	No	9	9
10	1x50	7x50	a2_off	96.827	1.70044	Yes	Yes	No	No	9	9
11	1x53	7x50	a2_off	95.9213	0	No	No	No	No	9	9
12	1x53	7x53	a2_off	95.6273	0	No	No	Yes	Yes	9	9
13	7x53	8x50	a2_off	55.9355	0	Yes	Yes	Yes	Yes	9	8
14	8x50	8x54	a2_off	12.3712	0	Yes	Yes	No	No	8	6
15	1x52	8x54	a2_off	10.4586	0	No	No	No	No	6	6
16	8x50	I1x50	a2_off	10.7931	0.831418	Yes	Yes	Yes	Yes	8	8
17	2x43	7x53	a2_off	33.1937	0	No	No	Yes	Yes	8	9
18	2x40	2x43	a2_off	32.6293	0	Yes	No	No	No	8	8
19	3x49	I2x57	a2_off	32.0583	0	Yes	No	Yes	No	9	7
20	2x38	I2x57	a2_off	20.7853	0	No	No	Yes	No	6	7
21	2x39	3x50	a2_off	17.7745	0	No	No	Yes	No	8	9
22	5x42	E2	a2_off	17.7373	5.03865	Yes	Yes	Yes	Yes	4	3
23	5x42	5x461	a2_off	20.9644	0	Yes	Yes	Yes	No	4	5
24	3x37	5x461	a2_off	21.032	1.22833	Yes	Yes	Yes	No	5	5
25	3x37	4x53	a2_off	49.3765	0	Yes	Yes	No	No	5	7
26	3x38	4x53	a2_off	48.873	1.83831	No	No	No	No	6	7
27	3x38	4x50	a2_off	47.7951	3.67245	No	No	Yes	No	6	9
28	2x45	4x50	a2_off	44.5207	7.31565	No	No	Yes	No	9	9
29	3x40	6x44	a2_off	44.8282	0	No	No	Yes	Yes	7	9
30	3x37	3x40	a2_off	42.2465	9.99791	Yes	Yes	No	No	5	7
31	2x42	3x46	a2_off	37.7657	0	Yes	Yes	No	No	7	8
32	2x53	7x46	a2_off	16.8249	0	No	No	No	No	6	9
33	2x53	3x35	a2_off	13.5809	0	No	No	No	No	6	7
34	3x31	3x35	a2_off	11.3844	8.51891	Yes	No	No	No	5	7
35	3x46	6x37	a2_off	36.6201	0	No	No	No	No	8	8
36	3x47	5x58	a2_off	33.2612	0	No	No	No	Yes	9	9
37	3x49	I2x53	a2_off	13.4626	7.817	Yes	No	Yes	Yes	9	7
38	3x50	I2x53	a2_off	13.3444	0	Yes	No	Yes	Yes	9	7
39	3x47	5x57	a2_off	32.0887	0	No	No	No	No	9	7
40	3x52	I2x53	a2_off	16.9094	0	No	No	Yes	Yes	5	7
41	3x54	5x61	a2_off	22.4411	2.73658	Yes	No	No	No	8	9
42	3x52	3x56	a2_off	20.4609	5.69877	No	No	No	No	5	5
43	3x56	I2x52	a2_off	10.2423	3.44266	No	No	No	No	5	5
44	2x38	4x39	a2_off	17.3994	0	No	No	No	No	6	1
45	5x37	6x59	a2_off	10.1037	0	No	No	Yes	No	4	3
46	6x40	7x52	a2_off	18.3624	0	No	No	No	No	8	8
47	6x39	7x52	a2_off	14.0777	4.8005	No	No	No	No	6	8
48	6x39	7x56	a2_off	12.9862	3.58053	No	No	Yes	No	6	7
49	3x54	5x68	a2_off	13.9019	0	Yes	No	No	No	8	6
50	5x68	6x27	a2_off	11.5906	0	No	No	No	No	6	4
51	2x41	4x39	a2_off	10.5194	0	No	No	No	No	5	1
52	6x48	Lig	Shared	72.8821	100	Yes	Yes	Yes	Yes	8	0
53	6x44	6x48	Shared	74.2608	66.7057	Yes	Yes	Yes	Yes	9	8
54	1x50	2x50	Shared	97.6244	21.433	Yes	Yes	No	Yes	9	9
55	2x40	8x50	Shared	34.7853	33.0645	Yes	No	Yes	Yes	8	8
56	2x37	2x40	Shared	67.6714	51.8696	No	No	Yes	No	7	8
57	2x37	2x39	Shared	66.1339	54.7692	No	No	No	No	7	8
58	2x39	3x49	Shared	46.8016	48.6275	No	No	Yes	No	8	9
59	E2	Lig	Shared	32.6429	50.023	Yes	Yes	Yes	Yes	3	0
60	2x45	4x46	Shared	42.3039	75.9348	No	No	No	No	9	8
61	2x42	4x46	Shared	41.1854	74.7149	Yes	Yes	No	No	7	8
62	6x52	Lig	Shared	16.7776	15.7802	Yes	Yes	Yes	Yes	6	0
63	5x58	6x37	Shared	35.4408	44.1278	No	Yes	No	No	9	8
64	5x57	5x61	Shared	30.9093	21.4623	No	No	No	No	7	9
65	5x44	6x52	Shared	15.5544	13.9085	Yes	Yes	Yes	Yes	5	6
66	6x40	7x53	Shared	19.2546	12.9685	No	No	Yes	Yes	8	9
67	7x30	7x32	a2_on	0	18.0823	No	No	No	No	3	1
68	7x30	E3	a2_on	0	20.7395	No	No	Yes	Yes	3	2
69	6x54	E3	a2_on	0	25.9411	No	No	Yes	Yes	5	2
70	6x54	7x34	a2_on	7.92079	27.0315	No	No	No	No	5	4
71	7x34	Lig	a2_on	7.55922	28.1136	No	No	Yes	Yes	4	0
72	7x42	Lig	a2_on	0	18.4583	Yes	Yes	Yes	Yes	6	0
73	6x48	7x45	a2_on	0	47.7585	Yes	Yes	No	No	8	9
74	7x45	7x49	a2_on	0	46.5218	No	No	No	Yes	9	9
75	2x50	7x49	a2_on	0	19.0474	No	Yes	No	Yes	9	9
76	1x50	2x51	a2_on	2.32825	10.0982	Yes	Yes	No	No	9	7
77	3x43	6x44	a2_on	6.91042	50.9756	No	Yes	Yes	Yes	8	9
78	2x46	3x43	a2_on	0	51.7777	No	Yes	No	Yes	9	8
79	2x46	3x42	a2_on	0	83.4677	No	Yes	No	No	9	7
80	2x45	3x42	a2_on	1.34491	82.2227	No	No	No	No	9	7
81	2x42	3x49	a2_on	0	57.2467	Yes	Yes	Yes	No	7	9
82	7x54	8x50	a2_on	0	14.9614	No	No	Yes	Yes	7	8
83	1x53	7x54	a2_on	0	13.3027	No	No	No	No	9	7
84	2x46	7x49	a2_on	1.16582	34.9781	No	Yes	No	Yes	9	9
85	1x53	7x55	a2_on	0	11.6357	No	No	No	Yes	9	6
86	2x40	I1x50	a2_on	1.87206	17.3303	Yes	No	Yes	Yes	8	8
87	8x53	I1x50	a2_on	2.02413	11.7443	No	No	Yes	Yes	7	8
88	2x42	4x42	a2_on	0	19.4109	Yes	Yes	No	No	7	7
89	3x26	E2	a2_on	1.00024	22.724	No	No	Yes	Yes	6	3
90	3x26	4x61	a2_on	0	20.259	No	No	No	Yes	6	5
91	3x27	4x61	a2_on	1.15568	15.2246	No	No	No	Yes	4	5
92	3x27	3x31	a2_on	5.77501	13.8667	No	No	Yes	No	4	5
93	3x25	E2	a2_on	7.41392	13.7205	No	No	Yes	Yes	9	3
94	3x25	E2x50	a2_on	6.44409	12.5423	No	No	No	No	9	9
95	E1x52	E2x50	a2_on	0	11.1636	No	No	No	No	6	9
96	3x40	6x48	a2_on	0	11.2346	No	No	Yes	Yes	7	8
97	3x43	7x53	a2_on	0	19.2313	No	Yes	Yes	Yes	8	9
98	5x54	6x44	a2_on	0	38.6547	No	No	Yes	Yes	8	9
99	5x54	5x58	a2_on	0	37.0671	No	No	No	Yes	8	9
100	5x61	6x37	a2_on	0	23.8312	No	No	No	No	9	8
101	5x53	5x57	a2_on	0	17.159	No	No	No	No	6	7
102	3x44	5x53	a2_on	0	16.3359	No	No	No	No	7	6
103	3x44	3x48	a2_on	1.16582	13.0102	No	No	No	No	7	6
104	3x48	3x52	a2_on	0	12.5924	No	No	No	No	6	5
105	I2x53	I2x57	a2_on	0.273713	11.5145	Yes	Yes	Yes	No	7	7
106	4x39	4x42	a2_on	0	12.4838	No	No	No	No	1	7
107	4x38	4x39	a2_on	5.28841	10.7249	No	No	No	No	7	1
108	5x58	6x40	a2_on	0	12.6969	No	Yes	No	No	9	8
109	5x62	6x37	a2_on	0	30.3948	No	Yes	No	No	5	8
110	5x62	6x30	a2_on	0	25.2768	No	Yes	No	Yes	5	7
111	5x69	6x30	a2_on	0	12.8222	No	Yes	No	Yes	5	7
112	8x53	8x57	a2_on	0	10.3447	No	No	No	No	7	6
113	1x46	7x47	a2_on	4.53148	10.0104	No	No	No	No	7	7
114	2x46	2x50	a2_on	0	13.6996	No	Yes	No	Yes	9	9
115	3x52	I2x57	a2_on	8.64732	10.2361	No	No	Yes	No	5	7

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
1x35	1x39	Shared	15.5385	16.555	0	1	2	2
1x39	2x57	Shared	7.25231	7.175	5	1	2	2
1x39	7x42	Shared	12.8304	10.7725	5	1	2	1
2x57	7x42	Shared	10.3508	6.96	5	1	2	1
E1x51	E2	Shared	13.8646	1.6175	0	0	2	1
3x22	E2	Shared	14.8412	23.855	0	0	2	1
3x25	E2	Shared	4.46731	5.125	1	1	2	1
3x26	E2	Shared	14.4565	11.0225	0	1	2	1
3x33	5x39	Shared	3.69923	3.5175	1	1	2	2
3x33	5x43	a2_off	7.29	0	1	1	2	1
3x36	6x48	a2_off	5.31846	0	0	0	1	1
3x37	3x40	Shared	4.325	4.12	1	1	2	2
3x40	6x44	a2_off	5.74692	0	0	0	2	2
4x60	5x39	Shared	16.5296	13.5625	1	1	2	2
5x36	E2	Shared	18.9138	10.255	1	0	2	1
5x38	E2	Shared	9.51808	2.165	1	0	2	1
5x39	E2	Shared	13.4665	10.555	1	1	2	1
E2	E2	Shared	77.385	14.46	1	1	1	1
E2	E2x51	Shared	13.7869	13.7675	1	1	1	2
E2	E2x52	Shared	13.9485	11.395	1	1	1	1
5x40	E2x52	Shared	6.74423	4.0425	1	1	1	1
E2x52	Lig	Shared	34.7573	31.85	1	1	1	0
5x36	5x38	a2_off	4.76461	0	1	0	2	2
5x37	6x55	Shared	7.33423	5.6075	1	0	2	1
5x39	5x40	a2_off	3.72846	0	1	1	2	1
5x39	5x42	Shared	9.68077	9.5425	1	1	2	2
5x39	5x43	a2_off	7.69231	0	1	1	2	1
5x40	Lig	Shared	4.89269	8.0775	1	1	1	0
5x44	5x47	Shared	3.42615	4.585	1	1	2	2
5x44	6x52	Shared	24.8892	17.82	1	1	2	1
5x47	6x52	Shared	6.49423	8.9925	1	1	2	1
6x44	6x48	Shared	14.8412	12.025	0	0	2	1
6x44	7x45	a2_off	8.18077	0	0	0	2	2
6x48	7x41	Shared	9.77385	5.25	0	0	1	2
6x51	Lig	Shared	15.2354	4.5325	0	0	1	0
6x54	7x34	Shared	3.36615	3.04	0	4	2	1
6x55	Lig	Shared	10.3565	7.1825	0	1	1	0
6x58	E3	Shared	10.3196	2.5625	0	0	2	1
6x61	E3	Shared	10.18	5.815	0	4	2	1
7x34	E3	a2_off	4.99385	0	1	0	1	1
7x34	Lig	Shared	4.96692	4.3325	1	0	1	0
7x38	7x42	Shared	4.03039	4.6425	0	1	1	1
7x38	Lig	Shared	10.1685	10.82	0	1	1	0
1x35	2x64	Shared	4.25808	5.725	0	1	2	1
3x23	E2	Shared	7.69	2.9775	1	0	2	1
3x33	5x40	Shared	3.53462	3.18	1	1	2	1
5x42	E2	Shared	6.28615	3.51	1	1	2	1
5x37	E2	a2_off	4.26692	0	1	0	2	1
E2	E3	a2_off	8.47615	0	1	1	1	1
E2	Lig	Shared	6.94308	3.82	1	1	1	0
5x43	6x52	Shared	3.48539	3.51	1	1	1	1
6x48	Lig	Shared	4.33308	3.51	0	0	1	0
6x52	Lig	Shared	5.53308	5.0825	1	1	1	0
E3	Lig	a2_off	5.34269	0	1	4	1	0
6x51	7x37	Shared	3.09077	2.545	0	0	1	2
2x66	E2x51	a2_off	3.02538	0	0	0	2	2
3x29	E2x52	Shared	2.87692	3.1175	0	0	2	1
2x60	7x42	Shared	2.81692	1.8275	0	0	2	1
4x63	E2	a2_off	2.22	0	0	0	2	1
1x35	7x38	a2_on	0	6.9525	0	1	2	1
3x33	E2x52	a2_on	0	3.3525	1	1	2	1
3x36	Lig	a2_on	0	8.355	0	0	1	0
3x37	5x43	a2_on	0	4.29	1	1	2	1
3x40	6x48	a2_on	0	12.3325	0	0	2	1
5x40	6x55	a2_on	0	3.505	1	1	1	1
6x48	7x45	a2_on	0	9.3225	0	0	1	2
6x51	7x41	a2_on	0	3.6375	0	0	1	2
E3	E3	a2_on	0	8.0675	1	4	1	1
7x30	E3	a2_on	0	5.8575	6	4	2	1
7x42	Lig	a2_on	0	4.8575	5	1	1	0
2x64	Lig	a2_on	0	3.9475	0	0	1	0
4x60	E2	a2_on	0	3.2225	1	1	2	1
5x40	5x43	a2_on	0	3.155	1	1	1	1
5x43	Lig	a2_on	0	5.3	1	1	1	0
6x54	E3	a2_on	0	1.9	0	4	2	1
2x66	E2	a2_on	0	1.305	0	0	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	a2_off	a2a_off
	a2_on	a2b_on

Network Difference
Value	a2_off	a2_on
I_min	3.35231	3.11
Number of Linked Nodes	271	257
Number of Specific Nodes	18 (6.64%)	4 (1.56%)
Number of Shared Nodes	253 (93.36%)	253 (98.44%)
Number of Links	307	294
Number of Specific Links	136 (44.30%)	123 (41.84%)
Number of Shared Links	171 (55.70%)	171 (58.16%)
Number of Hubs	40	35
Number of Specific Hubs	19 (47.50%)	14 (40.00%)
Number of Shared Hubs	21 (52.50%)	21 (60.00%)
Average % Shared Neighbours (Jaccard)	42.72
Average % Shared Neighbours (Otsuka)	52.26
Average % Shared Neighbours (Overlap Coefficient)	62.13
Average % Shared Cliques (k3-6)	80.95
Graphlets Similarity	0.601108

Paths Difference
Value	a2_off	a2_on
Number Of Nodes in MetaPath	65	63
Specific Nodes in MetaPath	34 (52.31%)	32 (50.79%)
Shared Nodes in MetaPath	253 (93.36%)	253 (93.36%)
Number Of Links MetaPath	66	64
Specific Links in MetaPath	51 (77.27%)	49 (76.56%)
Shared Links in MetaPath	171 (55.70%)	171 (55.70%)
Number of Shortest Paths	55987	49425
Length Of Smallest Path	3	3
Average Path Length	16.7498	13.3707
Length of Longest Path	41	31
Minimum Path Strength	0.269808	0.615
Average Path Strength	6.26313	5.25778
Maximum Path Strength	21.7265	18.2508
Minimum Path Correlation	0.701154	0.7
Average Path Correlation	0.922956	0.924727
Maximum Path Correlation	0.99	0.99
Minimum % Of Corr. Nodes	2.85714	4
Average % Of Corr. Nodes	40.6574	44.922
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	40.1791	42.1495
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download a2_off_on.zip<

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