psnGPCR

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Orange: nodes, hubs and links specific of a2_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of a2_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	a2_off Int. Strength	a2_on Int. Strength	a2_off Hub1?	a2_on Hub1?	a2_off Hub2?	a2_on Hub2?	ConSurf1	ConSurf2
1	1x52	8x57	a2_off	100	0	No	No	No	No	6	6
2	1x53	7x50	a2_off	100	0	No	No	No	No	9	9
3	1x53	7x53	a2_off	100	0	No	No	Yes	Yes	9	9
4	1x55	1x59	a2_off	100	0	No	No	No	No	4	5
5	1x55	8x57	a2_off	100	0	No	No	No	No	4	6
6	1x55	8x61	a2_off	100	0	No	No	No	No	4	4
7	1x59	8x57	a2_off	100	0	No	No	No	No	5	6
8	1x60	I1x49	a2_off	100	0	Yes	No	No	No	6	5
9	1x60	8x49	a2_off	100	0	Yes	No	Yes	No	6	6
10	2x38	I2x57	a2_off	100	0	No	No	Yes	No	6	7
11	2x38	4x42	a2_off	100	0	No	No	No	No	6	7
12	2x39	3x50	a2_off	100	0	No	No	Yes	No	8	9
13	2x40	2x43	a2_off	100	0	Yes	Yes	No	No	8	8
14	2x42	3x45	a2_off	100	0	Yes	Yes	No	No	7	7
15	2x42	3x46	a2_off	100	0	Yes	Yes	No	No	7	8
16	2x43	7x53	a2_off	100	0	No	No	Yes	Yes	8	9
17	2x45	4x50	a2_off	100	0	No	No	No	No	9	9
18	2x46	3x39	a2_off	100	0	No	No	No	No	9	9
19	2x53	3x35	a2_off	100	0	No	No	No	No	6	7
20	2x63	E2x50	a2_off	100	0	No	No	No	No	4	9
21	3x31	3x35	a2_off	100	0	Yes	No	No	No	5	7
22	3x33	5x40	a2_off	100	0	No	No	Yes	Yes	4	6
23	3x36	6x48	a2_off	100	0	No	No	Yes	Yes	6	8
24	3x37	3x40	a2_off	100	0	Yes	Yes	No	No	5	7
25	3x39	6x44	a2_off	100	0	No	No	Yes	Yes	9	9
26	3x40	5x50	a2_off	100	0	No	No	No	No	7	8
27	3x41	4x53	a2_off	100	0	Yes	No	No	No	5	7
28	3x43	6x41	a2_off	100	0	No	Yes	No	No	8	8
29	3x44	5x54	a2_off	100	0	No	No	No	No	7	8
30	3x46	6x37	a2_off	100	0	No	No	No	No	8	8
31	3x49	3x50	a2_off	100	0	Yes	No	Yes	No	9	9
32	3x49	I2x57	a2_off	100	0	Yes	No	Yes	No	9	7
33	3x50	3x53	a2_off	100	0	Yes	No	No	No	9	8
34	3x50	I2x53	a2_off	100	0	Yes	No	Yes	Yes	9	7
35	3x51	5x61	a2_off	100	0	No	No	No	No	8	9
36	3x54	6x30	a2_off	100	0	No	No	No	Yes	8	7
37	4x59	5x39	a2_off	100	0	No	No	Yes	Yes	6	6
38	5x38	E2	a2_off	100	0	No	No	Yes	Yes	4	3
39	5x37	E2	a2_off	100	0	No	No	Yes	Yes	4	3
40	E2	E3	a2_off	100	0	Yes	Yes	Yes	Yes	3	2
41	5x41	5x45	a2_off	100	0	No	No	No	No	5	4
42	5x411	6x60	a2_off	100	0	No	No	Yes	No	5	6
43	5x42	5x461	a2_off	100	0	No	Yes	Yes	Yes	4	5
44	5x43	6x52	a2_off	100	0	No	Yes	Yes	No	5	6
45	5x45	6x60	a2_off	100	0	No	No	Yes	No	4	6
46	5x54	6x41	a2_off	100	0	No	No	No	No	8	8
47	5x58	6x38	a2_off	100	0	No	Yes	No	No	9	5
48	5x62	6x35	a2_off	100	0	No	Yes	No	No	5	7
49	5x68	6x27	a2_off	100	0	No	No	No	No	6	4
50	5x69	6x27	a2_off	100	0	No	No	No	No	5	4
51	6x32	7x56	a2_off	100	0	No	No	Yes	No	8	7
52	6x35	7x56	a2_off	100	0	No	No	Yes	No	7	7
53	6x40	7x49	a2_off	100	0	No	No	Yes	Yes	8	9
54	6x40	7x52	a2_off	100	0	No	No	No	No	8	8
55	6x44	7x45	a2_off	100	0	Yes	Yes	No	No	9	9
56	6x56	6x60	a2_off	100	0	No	No	Yes	No	6	6
57	7x34	E3	a2_off	100	0	No	No	Yes	Yes	4	2
58	7x30	7x32	a2_off	100	0	No	No	No	No	3	1
59	7x32	7x33	a2_off	100	0	No	No	Yes	No	1	4
60	7x35	Lig	a2_off	100	0	No	No	Yes	Yes	3	0
61	7x49	7x53	a2_off	100	0	Yes	Yes	Yes	Yes	9	9
62	7x53	8x50	a2_off	100	0	Yes	Yes	Yes	Yes	9	8
63	8x48	8x52	a2_off	100	0	No	No	No	No	4	4
64	8x50	8x54	a2_off	100	0	Yes	Yes	Yes	No	8	6
65	8x55	8x59	a2_off	100	0	No	No	No	No	5	5
66	E3	Lig	a2_off	100	0	Yes	Yes	Yes	Yes	2	0
67	1x47	2x54	a2_off	80	0	No	No	No	No	6	7
68	2x56	3x32	a2_off	70	0	No	No	No	No	6	6
69	6x31	6x35	a2_off	60	0	No	No	No	No	5	7
70	6x47	7x40	a2_off	50	0	No	No	No	No	8	7
71	2x54	2x57	a2_off	40	0	No	No	Yes	Yes	7	6
72	5x69	6x24	a2_off	10	0	No	No	Yes	No	5	3
73	6x21	6x24	a2_off	30	0	No	No	Yes	No	4	3
74	6x54	7x33	a2_off	20	0	No	No	Yes	No	5	4
75	2x66	E2x51	a2_off	70	0	No	No	No	No	4	4
76	I2x56	I2x57	a2_off	40	0	No	No	Yes	No	4	7
77	1x42	2x57	a2_off	0	0	Yes	No	Yes	Yes	7	6
78	6x25	6x29	a2_off	50	0	No	No	No	No	4	6
79	2x41	4x43	a2_off	30	0	No	No	No	No	5	3
80	3x47	5x57	a2_off	50	0	No	No	No	No	9	7
81	6x49	6x53	a2_off	30	0	No	No	No	No	6	5
82	1x38	1x42	a2_off	10	0	No	No	Yes	No	5	7
83	3x29	E2x52	a2_off	0	0	No	No	Yes	No	5	4
84	7x54	8x54	a2_off	0	0	No	No	Yes	No	7	6
85	5x56	5x59	a2_off	40	0	No	No	No	No	4	4
86	1x58	1x59	a2_off	20	0	No	No	No	No	3	5
87	1x44	1x48	a2_off	0	0	No	No	No	No	4	5
88	5x51	6x45	a2_off	30	0	No	No	No	No	6	5
89	5x47	5x51	a2_off	0	0	No	No	No	No	7	6
90	I2x51	I2x52	a2_off	20	0	No	No	No	No	6	5
91	6x53	6x57	a2_off	0	0	No	No	No	No	5	4
92	1x57	8x50	a2_off	0	0	No	No	Yes	Yes	7	8
93	5x65	6x31	a2_off	10	0	No	No	No	No	8	5
94	2x38	4x39	a2_off	10	0	No	No	No	No	6	1
95	2x41	4x39	a2_off	10	0	No	No	No	No	5	1
96	5x49	5x53	a2_off	0	0	No	No	No	No	5	6
97	3x54	5x68	a2_off	20	0	No	No	No	No	8	6
98	7x47	7x51	a2_off	0	0	No	No	No	No	7	6
99	8x54	8x58	a2_off	10	0	Yes	No	No	No	6	6
100	6x22	6x26	a2_off	20	0	No	No	No	No	1	5
101	1x30	1x31	a2_off	0	0	Yes	No	No	No	4	5
102	5x62	5x66	a2_off	20	0	No	Yes	No	No	5	5
103	8x49	8x52	a2_off	10	0	Yes	No	No	No	6	4
104	7x33	7x36	a2_off	0	0	Yes	No	No	No	4	5
105	1x29	1x33	a2_off	0	0	No	No	No	No	5	4
106	1x32	1x36	a2_off	0	0	No	No	No	No	4	6
107	5x67	6x27	a2_off	10	0	No	No	No	No	4	4
108	3x55	5x64	a2_off	10	0	No	No	No	No	6	6
109	6x22	6x25	a2_off	20	0	No	No	No	No	1	4
110	4x59	4x62	a2_off	10	0	No	No	No	No	6	4
111	8x58	8x63	a2_off	0	0	No	No	No	No	6	0
112	6x43	6x46	a2_off	0	0	No	No	No	No	7	5
113	8x58	8x62	a2_off	10	0	No	No	No	No	6	6
114	5x72	I3	a2_off	10	0	No	No	No	No	0	0
115	5x72	6x24	a2_off	10	0	No	No	Yes	No	0	3
116	8x61	8x64	a2_off	10	0	No	No	No	No	4	0
117	6x23	6x26	a2_off	10	0	No	No	No	No	3	5
118	1x27	1x30	a2_off	10	0	No	No	Yes	No	0	4
119	1x30	1x32	a2_off	10	0	Yes	No	No	No	4	4
120	3x50	6x33	a2_off	10	0	Yes	No	No	No	9	8
121	8x64	8x65	a2_off	0	0	No	No	No	No	0	0
122	I2x54	I2x55	a2_off	10	0	No	No	No	No	5	5
123	5x70	5x73	a2_off	0	0	No	No	No	No	0	0
124	1x27	1x28	a2_off	0	0	No	No	No	No	0	6
125	3x23	3x24	a2_off	0	0	No	No	No	No	2	6
126	4x52	4x55	a2_off	0	0	No	No	No	No	4	4
127	5x73	6x24	a2_off	0	0	No	No	Yes	No	0	3
128	1x35	1x39	Shared	100	100	No	Yes	Yes	Yes	5	6
129	1x35	2x64	Shared	100	100	No	Yes	No	No	5	3
130	1x35	7x35	Shared	100	100	No	Yes	No	No	5	3
131	1x36	2x61	Shared	100	100	No	No	No	No	6	6
132	1x39	2x57	Shared	100	100	Yes	Yes	Yes	Yes	6	6
133	1x39	2x61	Shared	100	100	Yes	Yes	No	No	6	6
134	1x39	7x39	Shared	100	100	Yes	Yes	No	No	6	5
135	1x39	7x42	Shared	100	100	Yes	Yes	Yes	Yes	6	6
136	1x43	2x57	Shared	100	100	No	No	Yes	Yes	6	6
137	1x45	7x47	Shared	100	100	No	No	No	No	5	7
138	1x49	7x50	Shared	100	50	No	No	No	No	9	9
139	1x50	2x47	Shared	100	100	Yes	Yes	No	No	9	9
140	1x50	2x50	Shared	100	100	Yes	Yes	Yes	Yes	9	9
141	1x50	7x50	Shared	100	100	Yes	Yes	No	No	9	9
142	1x51	2x51	Shared	100	50	No	No	No	No	4	7
143	1x52	8x54	Shared	100	100	No	No	Yes	No	6	6
144	1x56	8x53	Shared	100	50	No	No	No	Yes	8	7
145	1x57	2x44	Shared	100	100	No	No	No	No	7	5
146	1x60	I1x50	Shared	100	100	Yes	No	Yes	Yes	6	8
147	1x60	8x53	Shared	100	100	Yes	No	No	Yes	6	7
148	8x49	I1x49	Shared	100	100	Yes	No	No	No	6	5
149	2x40	I1x50	Shared	100	100	Yes	Yes	Yes	Yes	8	8
150	8x49	I1x50	Shared	100	100	Yes	No	Yes	Yes	6	8
151	8x50	I1x50	Shared	100	100	Yes	Yes	Yes	Yes	8	8
152	8x53	I1x50	Shared	100	100	No	Yes	Yes	Yes	7	8
153	2x37	2x39	Shared	100	100	No	No	No	No	7	8
154	2x37	2x40	Shared	100	100	No	No	Yes	Yes	7	8
155	2x39	3x49	Shared	100	100	No	No	Yes	No	8	9
156	2x40	8x50	Shared	100	100	Yes	Yes	Yes	Yes	8	8
157	2x42	4x45	Shared	100	100	Yes	Yes	No	No	7	5
158	2x42	4x46	Shared	100	50	Yes	Yes	No	No	7	8
159	2x45	3x42	Shared	100	100	No	No	No	No	9	7
160	2x45	4x46	Shared	100	100	No	No	No	No	9	8
161	2x46	7x49	Shared	100	100	No	No	Yes	Yes	9	9
162	2x50	3x39	Shared	100	100	Yes	Yes	No	No	9	9
163	2x50	7x46	Shared	100	100	Yes	Yes	No	No	9	9
164	2x50	7x49	Shared	100	100	Yes	Yes	Yes	Yes	9	9
165	2x52	3x35	Shared	100	100	No	No	No	No	6	7
166	2x53	2x56	Shared	100	100	No	No	No	No	6	6
167	2x53	7x46	Shared	100	100	No	No	No	No	6	9
168	2x551	3x31	Shared	100	62.5	No	No	Yes	No	5	5
169	2x57	2x58	Shared	100	100	Yes	Yes	No	No	6	8
170	2x57	7x42	Shared	100	100	Yes	Yes	Yes	Yes	6	6
171	2x59	3x28	Shared	100	100	No	No	No	No	5	6
172	2x59	3x31	Shared	100	100	No	No	Yes	No	5	5
173	2x62	E1x50	Shared	100	12.5	No	No	Yes	Yes	5	7
174	E1x50	E1x52	Shared	100	100	Yes	Yes	No	No	7	6
175	E1x50	E2x50	Shared	100	100	Yes	Yes	No	No	7	9
176	E1x51	E2	Shared	100	12.5	No	No	Yes	Yes	2	3
177	3x22	E2	Shared	100	100	No	No	Yes	Yes	3	3
178	3x23	E2	Shared	100	25	No	No	Yes	Yes	2	3
179	3x25	E2x50	Shared	100	100	No	No	No	No	9	9
180	3x25	E2	Shared	100	100	No	No	Yes	Yes	9	3
181	3x26	E2	Shared	100	100	No	No	Yes	Yes	6	3
182	3x27	3x31	Shared	100	100	No	No	Yes	No	4	5
183	3x27	4x61	Shared	100	100	No	No	No	Yes	4	5
184	3x30	4x60	Shared	100	100	No	No	No	No	5	5
185	3x33	5x39	Shared	100	100	No	No	Yes	Yes	4	6
186	3x33	5x43	Shared	100	100	No	No	No	Yes	4	5
187	3x34	4x54	Shared	100	100	No	No	No	No	4	3
188	3x34	4x58	Shared	100	0	No	No	No	No	4	3
189	3x37	3x41	Shared	100	100	Yes	Yes	Yes	No	5	5
190	3x37	4x53	Shared	100	50	Yes	Yes	No	No	5	7
191	3x37	4x56	Shared	100	100	Yes	Yes	No	Yes	5	4
192	3x37	5x461	Shared	100	100	Yes	Yes	Yes	Yes	5	5
193	3x38	4x50	Shared	100	100	No	No	No	No	6	9
194	3x38	4x53	Shared	100	100	No	No	No	No	6	7
195	3x40	6x44	Shared	100	100	No	No	Yes	Yes	7	9
196	3x41	4x49	Shared	100	100	Yes	No	No	No	5	7
197	3x43	6x44	Shared	100	100	No	Yes	Yes	Yes	8	9
198	3x44	3x48	Shared	100	0	No	No	No	No	7	6
199	3x47	5x58	Shared	100	100	No	No	No	Yes	9	9
200	3x49	I2x53	Shared	100	100	Yes	No	Yes	Yes	9	7
201	3x51	3x55	Shared	100	100	No	No	No	No	8	6
202	3x51	5x60	Shared	100	100	No	No	No	No	8	5
203	3x52	I2x57	Shared	100	0	No	No	Yes	No	5	7
204	3x53	I2x53	Shared	100	100	No	No	Yes	Yes	8	7
205	3x56	I2x52	Shared	100	100	No	No	No	No	5	5
206	I2x53	I2x54	Shared	100	62.5	Yes	Yes	No	No	7	5
207	I2x53	I2x57	Shared	100	100	Yes	Yes	Yes	No	7	7
208	4x38	4x41	Shared	100	100	No	No	No	No	7	5
209	4x56	5x461	Shared	100	100	No	Yes	Yes	Yes	4	5
210	4x58	4x61	Shared	100	25	No	No	No	Yes	3	5
211	4x59	4x60	Shared	100	100	No	No	No	No	6	5
212	4x60	5x39	Shared	100	100	No	No	Yes	Yes	5	6
213	5x36	E2	Shared	100	100	No	No	Yes	Yes	4	3
214	5x39	E2	Shared	100	100	Yes	Yes	Yes	Yes	6	3
215	5x42	E2	Shared	100	100	No	Yes	Yes	Yes	4	3
216	E2	E2	Shared	100	100	Yes	Yes	Yes	Yes	3	3
217	E2	E2x51	Shared	100	100	Yes	Yes	No	No	3	4
218	E2	E2x52	Shared	100	100	Yes	Yes	Yes	No	3	4
219	5x40	E2x52	Shared	100	100	Yes	Yes	Yes	No	6	4
220	E2x52	Lig	Shared	100	100	Yes	No	Yes	Yes	4	0
221	E2	Lig	Shared	100	100	Yes	Yes	Yes	Yes	3	0
222	5x36	5x38	Shared	100	100	No	No	No	No	4	4
223	5x37	6x55	Shared	100	100	No	No	No	No	4	5
224	5x37	6x59	Shared	100	62.5	No	No	Yes	Yes	4	3
225	5x39	5x40	Shared	100	100	Yes	Yes	Yes	Yes	6	6
226	5x39	5x42	Shared	100	100	Yes	Yes	No	Yes	6	4
227	5x39	5x43	Shared	100	100	Yes	Yes	No	Yes	6	5
228	5x40	Lig	Shared	100	100	Yes	Yes	Yes	Yes	6	0
229	5x41	6x59	Shared	100	100	No	No	Yes	Yes	5	3
230	5x411	6x59	Shared	100	100	No	No	Yes	Yes	5	3
231	5x44	5x45	Shared	100	100	Yes	Yes	No	No	5	4
232	5x44	5x47	Shared	100	100	Yes	Yes	No	No	5	7
233	5x44	5x48	Shared	100	100	Yes	Yes	No	No	5	4
234	5x44	6x52	Shared	100	100	Yes	Yes	Yes	No	5	6
235	5x47	6x52	Shared	100	100	No	No	Yes	No	7	6
236	5x49	5x50	Shared	100	100	No	No	No	No	5	8
237	5x58	6x37	Shared	100	100	No	Yes	No	No	9	8
238	6x24	6x28	Shared	100	50	Yes	No	No	No	3	4
239	6x36	7x56	Shared	100	100	No	No	Yes	No	8	7
240	6x39	7x56	Shared	100	100	No	No	Yes	No	6	7
241	6x40	7x53	Shared	100	100	No	No	Yes	Yes	8	9
242	6x44	6x48	Shared	100	100	Yes	Yes	Yes	Yes	9	8
243	6x47	7x45	Shared	100	100	No	No	No	No	8	9
244	6x48	7x41	Shared	100	100	Yes	Yes	No	No	8	7
245	6x48	7x45	Shared	100	100	Yes	Yes	No	No	8	9
246	6x48	Lig	Shared	100	100	Yes	Yes	Yes	Yes	8	0
247	6x50	7x40	Shared	100	0	No	No	No	No	9	7
248	6x51	Lig	Shared	100	100	No	No	Yes	Yes	5	0
249	6x52	Lig	Shared	100	100	Yes	No	Yes	Yes	6	0
250	6x55	Lig	Shared	100	100	No	No	Yes	Yes	5	0
251	6x58	E3	Shared	100	12.5	No	No	Yes	Yes	4	2
252	6x59	6x60	Shared	100	50	Yes	Yes	Yes	No	3	6
253	6x61	E3	Shared	100	100	No	No	Yes	Yes	4	2
254	7x30	7x33	Shared	100	100	No	No	Yes	No	3	4
255	7x31	7x35	Shared	100	100	No	No	No	No	3	3
256	7x34	Lig	Shared	100	100	No	No	Yes	Yes	4	0
257	7x38	7x42	Shared	100	100	No	Yes	Yes	Yes	4	6
258	7x38	Lig	Shared	100	100	No	Yes	Yes	Yes	4	0
259	7x41	7x42	Shared	100	100	No	No	Yes	Yes	7	6
260	8x47	8x50	Shared	100	100	No	No	Yes	Yes	8	8
261	8x48	8x51	Shared	100	12.5	No	No	No	No	4	8
262	8x51	8x55	Shared	100	0	No	No	No	No	8	5
263	8x60	8x61	Shared	100	100	No	No	No	No	4	4
264	6x54	7x34	Shared	30	25	No	No	No	No	5	4
265	3x41	4x52	Shared	40	100	Yes	No	No	No	5	4
266	1x47	2x55	Shared	40	100	No	No	No	No	6	5
267	5x55	5x59	Shared	60	12.5	No	No	No	No	4	4
268	I1x48	I1x51	Shared	40	50	No	No	No	No	5	7
269	6x51	7x37	Shared	40	75	No	No	No	No	5	6
270	6x43	7x48	Shared	40	100	No	No	No	No	7	6
271	1x50	2x51	Shared	10	100	Yes	Yes	No	No	9	7
272	4x56	4x57	Shared	60	50	No	Yes	No	No	4	6
273	3x54	5x61	Shared	20	100	No	No	No	No	8	9
274	2x60	7x42	Shared	0	12.5	No	No	Yes	Yes	5	6
275	2x65	E1x50	Shared	70	100	No	No	Yes	Yes	5	7
276	6x43	7x52	Shared	10	0	No	No	No	No	7	8
277	2x49	4x50	Shared	0	0	No	No	No	No	8	9
278	1x36	1x40	Shared	0	25	No	No	No	No	6	5
279	5x48	5x52	Shared	30	12.5	No	No	No	No	4	3
280	5x57	5x61	Shared	0	12.5	No	No	No	No	7	9
281	1x42	7x43	Shared	10	62.5	Yes	No	No	No	7	5
282	6x39	7x52	Shared	30	12.5	No	No	No	No	6	8
283	5x62	6x34	Shared	0	100	No	Yes	No	No	5	7
284	6x45	6x49	Shared	10	0	No	No	No	No	5	6
285	4x48	4x52	Shared	0	12.5	No	No	No	No	3	4
286	3x52	3x56	Shared	0	100	No	No	No	No	5	5
287	1x46	7x46	Shared	0	100	No	No	No	No	7	9
288	1x48	1x49	Shared	0	0	No	No	No	No	5	9
289	1x54	2x44	Shared	10	25	No	No	No	No	7	5
290	4x63	E2	Shared	20	0	No	No	Yes	Yes	4	3
291	6x26	6x30	Shared	10	25	No	No	No	Yes	5	7
292	4x38	4x39	Shared	10	100	No	No	No	No	7	1
293	3x56	I2x50	Shared	0	0	No	No	No	No	5	8
294	1x34	1x38	Shared	0	100	No	No	No	No	5	5
295	4x38	4x40	Shared	0	0	No	No	No	No	7	5
296	1x42	7x47	Shared	0	50	Yes	No	No	No	7	7
297	5x63	5x66	Shared	30	50	No	No	No	No	4	5
298	2x41	I1x51	Shared	30	0	No	No	No	No	5	7
299	7x51	7x55	Shared	10	100	No	No	No	No	6	6
300	8x56	8x60	Shared	20	12.5	No	No	No	No	4	4
301	1x29	1x30	Shared	0	12.5	No	No	Yes	No	5	4
302	4x43	4x44	Shared	0	0	No	No	No	No	3	3
303	5x46	5x461	Shared	0	0	No	No	Yes	Yes	3	5
304	4x44	4x47	Shared	0	0	No	No	No	No	3	4
305	5x55	6x41	Shared	10	12.5	No	No	No	No	4	8
306	6x42	6x45	Shared	0	0	No	No	No	No	5	5
307	1x37	1x38	Shared	10	0	No	No	No	No	4	5
308	5x68	5x71	Shared	0	12.5	No	No	No	No	6	0
309	1x35	7x38	a2_on	0	100	No	Yes	No	Yes	5	4
310	1x35	7x39	a2_on	0	100	No	Yes	No	No	5	5
311	1x35	7x42	a2_on	0	100	No	Yes	Yes	Yes	5	6
312	1x38	7x39	a2_on	0	100	No	No	No	No	5	5
313	1x39	7x38	a2_on	0	100	Yes	Yes	No	Yes	6	4
314	1x53	7x54	a2_on	0	100	No	No	No	No	9	7
315	1x53	8x50	a2_on	0	100	No	No	Yes	Yes	9	8
316	1x57	2x40	a2_on	0	100	No	No	Yes	Yes	7	8
317	1x60	8x52	a2_on	0	100	Yes	No	No	No	6	4
318	2x42	3x49	a2_on	0	100	Yes	Yes	Yes	No	7	9
319	2x46	2x50	a2_on	0	100	No	No	Yes	Yes	9	9
320	2x46	3x42	a2_on	0	100	No	No	No	No	9	7
321	2x55	2x551	a2_on	0	100	No	No	No	No	5	5
322	2x56	3x35	a2_on	0	100	No	No	No	No	6	7
323	2x63	3x28	a2_on	0	100	No	No	No	No	4	6
324	3x26	3x30	a2_on	0	100	No	No	No	No	6	5
325	3x26	4x61	a2_on	0	100	No	No	No	Yes	6	5
326	3x36	Lig	a2_on	0	100	No	No	Yes	Yes	6	0
327	3x40	6x48	a2_on	0	100	No	No	Yes	Yes	7	8
328	3x43	5x54	a2_on	0	100	No	Yes	No	No	8	8
329	3x43	7x49	a2_on	0	100	No	Yes	Yes	Yes	8	9
330	3x43	7x53	a2_on	0	100	No	Yes	Yes	Yes	8	9
331	3x44	5x53	a2_on	0	100	No	No	No	No	7	6
332	3x46	7x53	a2_on	0	100	No	No	Yes	Yes	8	9
333	3x50	5x58	a2_on	0	100	Yes	No	No	Yes	9	9
334	3x50	7x53	a2_on	0	100	Yes	No	Yes	Yes	9	9
335	3x51	5x57	a2_on	0	100	No	No	No	No	8	7
336	4x52	4x56	a2_on	0	100	No	No	No	Yes	4	4
337	4x56	5x42	a2_on	0	100	No	Yes	No	Yes	4	4
338	4x59	5x42	a2_on	0	100	No	No	No	Yes	6	4
339	5x40	5x43	a2_on	0	100	Yes	Yes	No	Yes	6	5
340	5x40	6x55	a2_on	0	100	Yes	Yes	No	No	6	5
341	5x41	6x56	a2_on	0	100	No	No	No	No	5	6
342	5x43	5x461	a2_on	0	100	No	Yes	Yes	Yes	5	5
343	5x43	Lig	a2_on	0	100	No	Yes	Yes	Yes	5	0
344	5x45	5x49	a2_on	0	100	No	No	No	No	4	5
345	5x51	6x44	a2_on	0	100	No	No	Yes	Yes	6	9
346	5x54	5x58	a2_on	0	100	No	No	No	Yes	8	9
347	5x54	6x44	a2_on	0	100	No	No	Yes	Yes	8	9
348	5x58	6x40	a2_on	0	100	No	Yes	No	No	9	8
349	5x58	6x41	a2_on	0	100	No	Yes	No	No	9	8
350	5x58	7x53	a2_on	0	100	No	Yes	Yes	Yes	9	9
351	5x61	6x37	a2_on	0	100	No	No	No	No	9	8
352	5x62	6x30	a2_on	0	100	No	Yes	No	Yes	5	7
353	5x66	6x30	a2_on	0	100	No	No	No	Yes	5	7
354	5x69	6x29	a2_on	0	100	No	No	No	No	5	6
355	6x51	7x41	a2_on	0	100	No	No	No	No	5	7
356	E3	E3	a2_on	0	100	Yes	Yes	Yes	Yes	2	2
357	7x30	E3	a2_on	0	100	No	No	Yes	Yes	3	2
358	7x42	Lig	a2_on	0	100	Yes	Yes	Yes	Yes	6	0
359	7x45	7x49	a2_on	0	100	No	No	Yes	Yes	9	9
360	7x52	7x53	a2_on	0	100	No	No	Yes	Yes	8	9
361	8x52	8x53	a2_on	0	100	No	No	No	Yes	4	7
362	1x29	1x32	a2_on	0	100	No	No	No	No	5	4
363	6x57	E3	a2_on	0	50	No	No	Yes	Yes	4	2
364	2x42	4x42	a2_on	0	50	Yes	Yes	No	No	7	7
365	3x44	5x50	a2_on	0	50	No	No	No	No	7	8
366	1x33	7x35	a2_on	0	50	No	No	No	No	4	3
367	3x52	I2x56	a2_on	0	62.5	No	No	No	No	5	4
368	6x29	6x32	a2_on	0	50	No	No	No	No	6	8
369	5x51	6x49	a2_on	0	50	No	No	No	No	6	6
370	2x53	2x54	a2_on	0	50	No	No	No	No	6	7
371	5x73	6x26	a2_on	0	50	No	No	No	No	0	5
372	1x31	7x32	a2_on	0	50	No	No	No	No	5	1
373	1x31	7x31	a2_on	0	50	No	No	No	No	5	3
374	3x29	E2	a2_on	0	50	No	No	Yes	Yes	5	3
375	4x40	4x43	a2_on	0	50	No	No	No	No	5	3
376	2x65	2x66	a2_on	0	50	No	No	No	No	5	4
377	1x59	8x53	a2_on	0	50	No	No	No	Yes	5	7
378	7x55	8x54	a2_on	0	50	No	No	Yes	No	6	6
379	2x37	2x38	a2_on	0	50	No	No	No	No	7	6
380	3x21	3x24	a2_on	0	50	No	No	No	No	7	6
381	1x46	7x47	a2_on	0	12.5	No	No	No	No	7	7
382	6x27	6x30	a2_on	0	25	No	No	No	Yes	4	7
383	3x32	Lig	a2_on	0	0	No	No	Yes	Yes	6	0
384	3x54	5x64	a2_on	0	0	No	No	No	No	8	6
385	4x39	4x42	a2_on	0	0	No	No	No	No	1	7
386	6x25	6x28	a2_on	0	50	No	No	No	No	4	4
387	1x56	8x54	a2_on	0	50	No	No	Yes	No	8	6
388	6x46	7x40	a2_on	0	0	No	No	No	No	5	7
389	1x32	7x31	a2_on	0	50	No	No	No	No	4	3
390	5x70	6x26	a2_on	0	12.5	No	No	No	No	0	5
391	6x27	6x31	a2_on	0	0	No	No	No	No	4	5
392	6x60	6x61	a2_on	0	0	Yes	No	No	No	6	4
393	5x62	6x37	a2_on	0	12.5	No	Yes	No	No	5	8
394	7x32	7x36	a2_on	0	50	No	No	No	No	1	5
395	3x45	4x49	a2_on	0	0	No	No	No	No	7	7
396	6x49	6x50	a2_on	0	0	No	No	No	No	6	9
397	3x21	E1x52	a2_on	0	50	No	No	No	No	7	6
398	5x62	6x33	a2_on	0	0	No	Yes	No	No	5	8
399	2x43	8x50	a2_on	0	12.5	No	No	Yes	Yes	8	8
400	5x69	6x30	a2_on	0	12.5	No	No	No	Yes	5	7
401	6x35	6x39	a2_on	0	0	No	No	No	No	7	6
402	6x28	6x31	a2_on	0	0	No	No	No	No	4	5
403	8x53	8x57	a2_on	0	25	No	Yes	No	No	7	6
404	8x52	8x56	a2_on	0	12.5	No	No	No	No	4	4
405	2x41	4x46	a2_on	0	0	No	No	No	No	5	8
406	7x55	8x51	a2_on	0	0	No	No	No	No	6	8
407	5x67	5x70	a2_on	0	12.5	No	No	No	No	4	0
408	5x73	I3	a2_on	0	25	No	No	No	No	0	0
409	5x56	5x60	a2_on	0	12.5	No	No	No	No	4	5
410	I2x55	I2x56	a2_on	0	12.5	No	No	No	No	5	4
411	5x65	6x33	a2_on	0	0	No	No	No	No	8	8
412	5x67	5x71	a2_on	0	12.5	No	No	No	No	4	0
413	1x41	1x45	a2_on	0	12.5	No	No	No	No	5	5
414	5x69	5x72	a2_on	0	12.5	No	No	No	No	5	0
415	1x57	1x58	a2_on	0	12.5	No	No	No	No	7	3
416	4x54	4x55	a2_on	0	0	No	No	No	No	3	4
417	1x27	2x65	a2_on	0	12.5	No	No	No	No	0	5
418	4x61	4x62	a2_on	0	12.5	No	Yes	No	No	5	4
419	8x55	8x58	a2_on	0	0	No	No	No	No	5	6
420	1x28	1x33	a2_on	0	0	No	No	No	No	6	4

Orange: nodes, hubs and links specific of a2_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of a2_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	a2_off Avg Int. Strength	a2_on Avg Int. Strength	a2_off Num Of Links	a2_on Num Of Links	ConSurf
1	1x30	a2_off	0	0	4	1	4
2	1x42	a2_off	0	0	4	2	7
3	1x60	a2_off	100	0	4	3	6
4	3x31	a2_off	80	0	4	3	5
5	3x41	a2_off	10	0	4	3	5
6	3x49	a2_off	70	0	4	3	9
7	3x50	a2_off	70	0	5	2	9
8	I2x57	a2_off	60	0	5	2	7
9	E2x52	a2_off	0	25	4	3	4
10	6x24	a2_off	0	0	5	1	3
11	6x52	a2_off	60	75	4	3	6
12	6x60	a2_off	70	0	4	2	6
13	7x33	a2_off	10	0	4	1	4
14	7x56	a2_off	20	0	4	2	7
15	8x49	a2_off	20	0	4	2	6
16	8x54	a2_off	0	0	4	3	6
17	1x39	Shared	100	87.5	5	6	6
18	1x50	Shared	0	75	4	4	9
19	I1x50	Shared	70	87.5	5	5	8
20	2x40	Shared	40	50	4	4	8
21	2x42	Shared	20	25	4	4	7
22	2x50	Shared	30	100	4	5	9
23	2x57	Shared	80	100	6	4	6
24	E1x50	Shared	70	0	4	4	7
25	3x37	Shared	100	87.5	5	4	5
26	I2x53	Shared	70	100	5	4	7
27	E2	Shared	100	100	17	15	3
28	5x39	Shared	100	100	7	6	6
29	5x40	Shared	60	87.5	4	5	6
30	5x44	Shared	50	50	4	4	5
31	5x461	Shared	0	0	4	4	5
32	6x44	Shared	100	75	5	5	9
33	6x48	Shared	90	100	5	5	8
34	6x59	Shared	80	0	4	4	3
35	E3	Shared	90	37.5	5	6	2
36	7x42	Shared	60	87.5	5	7	6
37	7x49	Shared	30	87.5	4	4	9
38	7x53	Shared	90	87.5	5	6	9
39	8x50	Shared	90	87.5	6	5	8
40	Lig	Shared	100	100	11	13	0
41	1x35	a2_on	60	87.5	3	6	5
42	3x43	a2_on	0	62.5	2	4	8
43	4x56	a2_on	10	12.5	3	5	4
44	4x61	a2_on	0	0	2	4	5
45	5x42	a2_on	10	50	3	4	4
46	5x43	a2_on	20	62.5	3	5	5
47	5x58	a2_on	20	100	3	7	9
48	5x62	a2_on	0	0	3	4	5
49	6x30	a2_on	0	0	2	5	7
50	7x38	a2_on	0	50	2	4	4
51	8x53	a2_on	0	50	3	6	7

Orange: nodes, hubs and links specific of a2_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of a2_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	a2_off Recurrence	a2_on Recurrence	a2_off Hub1?	a2_on Hub1?	a2_off Hub2?	a2_on Hub2?	ConSurf1	ConSurf2
1	1x39	2x61	a2_off	10.8249	9.34814	Yes	Yes	No	No	6	6
2	3x39	6x44	a2_off	100	0	No	No	Yes	Yes	9	9
3	2x50	3x39	a2_off	55.0089	1.70515	Yes	Yes	No	No	9	9
4	2x46	3x39	a2_off	45.2755	0	No	No	No	No	9	9
5	7x49	7x53	a2_off	81.2697	0	Yes	Yes	Yes	Yes	9	9
6	7x53	8x50	a2_off	55.9329	0	Yes	Yes	Yes	Yes	9	8
7	8x50	8x54	a2_off	14.0907	0	Yes	Yes	Yes	No	8	6
8	8x50	I1x50	a2_off	11.3498	0.478558	Yes	Yes	Yes	Yes	8	8
9	2x43	7x53	a2_off	29.2862	0	No	No	Yes	Yes	8	9
10	2x40	2x43	a2_off	28.499	0	Yes	Yes	No	No	8	8
11	2x40	8x50	a2_off	29.5993	7.21089	Yes	Yes	Yes	Yes	8	8
12	3x49	I2x57	a2_off	35.8994	0	Yes	No	Yes	No	9	7
13	2x38	I2x57	a2_off	23.0104	0	No	No	Yes	No	6	7
14	2x39	3x50	a2_off	10.4567	0	No	No	Yes	No	8	9
15	5x42	5x461	a2_off	10.331	0	No	Yes	Yes	Yes	4	5
16	3x37	5x461	a2_off	10.6353	9.73377	Yes	Yes	Yes	Yes	5	5
17	3x37	4x53	a2_off	36.5322	5.84956	Yes	Yes	No	No	5	7
18	3x38	4x53	a2_off	36.1066	4.39994	No	No	No	No	6	7
19	3x38	4x50	a2_off	35.2356	2.94104	No	No	No	No	6	9
20	2x45	4x50	a2_off	33.4803	0	No	No	No	No	9	9
21	3x40	6x44	a2_off	39.3901	0.678344	No	No	Yes	Yes	7	9
22	3x37	3x40	a2_off	36.8233	0	Yes	Yes	No	No	5	7
23	2x42	3x46	a2_off	28.0866	0	Yes	Yes	No	No	7	8
24	3x46	6x37	a2_off	27.1759	0	No	No	No	No	8	8
25	3x47	5x58	a2_off	24.5364	1.95605	No	No	No	Yes	9	9
26	3x47	5x57	a2_off	23.608	0	No	No	No	No	9	7
27	5x57	5x61	a2_off	22.6753	9.7059	No	No	No	No	7	9
28	3x54	5x61	a2_off	17.9276	3.47071	No	No	No	No	8	9
29	2x38	4x39	a2_off	19.2264	0	No	No	No	No	6	1
30	6x40	7x49	a2_off	13.2506	0	No	No	Yes	Yes	8	9
31	6x40	7x52	a2_off	15.76	0	No	No	No	No	8	8
32	6x39	7x52	a2_off	11.5614	5.35706	No	No	No	No	6	8
33	6x39	7x56	a2_off	10.4986	2.75055	No	No	Yes	No	6	7
34	3x54	5x68	a2_off	11.3321	0	No	No	No	No	8	6
35	2x41	4x39	a2_off	11.5879	0	No	No	No	No	5	1
36	2x57	7x42	a2_off	13.4623	5.7938	Yes	Yes	Yes	Yes	6	6
37	1x39	7x42	Shared	10.5559	14.9747	Yes	Yes	Yes	Yes	6	6
38	6x48	Lig	Shared	49.4807	100	Yes	Yes	Yes	Yes	8	0
39	6x44	6x48	Shared	70.6102	48.1624	Yes	Yes	Yes	Yes	9	8
40	2x46	7x49	Shared	45.1432	80.5882	No	No	Yes	Yes	9	9
41	2x50	7x49	Shared	50.1114	27.6077	Yes	Yes	Yes	Yes	9	9
42	2x37	2x40	Shared	57.1589	48.5155	No	No	Yes	Yes	7	8
43	2x37	2x39	Shared	55.3463	51.294	No	No	No	No	7	8
44	2x39	3x49	Shared	43.0638	52.6599	No	No	Yes	No	8	9
45	E2	Lig	Shared	24.7414	44.9194	Yes	Yes	Yes	Yes	3	0
46	2x45	4x46	Shared	31.7074	83.5571	No	No	No	No	9	8
47	2x42	4x46	Shared	30.8144	78.9295	Yes	Yes	No	No	7	8
48	2x50	7x46	Shared	10.6375	19.8996	Yes	Yes	No	No	9	9
49	6x52	Lig	Shared	14.9441	14.8028	Yes	No	Yes	Yes	6	0
50	5x58	6x37	Shared	26.2409	54.2815	No	Yes	No	No	9	8
51	7x41	7x42	Shared	20.6223	20.2109	No	No	Yes	Yes	7	6
52	6x48	7x41	Shared	21.4492	21.9068	Yes	Yes	No	No	8	7
53	1x38	7x39	a2_on	0	18.4222	No	No	No	No	5	5
54	1x35	7x39	a2_on	0	12.3171	No	Yes	No	No	5	5
55	1x39	7x39	a2_on	1.13784	12.2241	Yes	Yes	No	No	6	5
56	1x35	7x35	a2_on	3.92291	27.6774	No	Yes	No	No	5	3
57	1x35	7x38	a2_on	0	16.8517	No	Yes	No	Yes	5	4
58	1x35	7x42	a2_on	0	27.7052	No	Yes	Yes	Yes	5	6
59	7x38	Lig	a2_on	5.77301	26.9015	No	Yes	Yes	Yes	4	0
60	6x48	7x45	a2_on	0.976868	73.303	Yes	Yes	No	No	8	9
61	7x45	7x49	a2_on	0	72.7826	No	No	Yes	Yes	9	9
62	1x46	7x46	a2_on	0.710049	10.1148	No	No	No	No	7	9
63	7x42	Lig	a2_on	0	31.7614	Yes	Yes	Yes	Yes	6	0
64	3x26	E2	a2_on	0.820305	20.8103	No	No	Yes	Yes	6	3
65	3x26	4x61	a2_on	0	18.766	No	No	No	Yes	6	5
66	3x27	4x61	a2_on	2.82035	10.821	No	No	No	Yes	4	5
67	1x50	2x50	a2_on	4.96593	11.7688	Yes	Yes	Yes	Yes	9	9
68	2x46	3x42	a2_on	0	85.8152	No	No	No	No	9	7
69	2x45	3x42	a2_on	1.03641	84.6908	No	No	No	No	9	7
70	2x42	3x49	a2_on	0	66.631	Yes	Yes	Yes	No	7	9
71	2x40	I1x50	a2_on	0.871023	34.182	Yes	Yes	Yes	Yes	8	8
72	8x53	I1x50	a2_on	2.0662	23.4215	No	Yes	Yes	Yes	7	8
73	1x56	8x53	a2_on	1.05184	14.1569	No	No	No	Yes	8	7
74	1x56	8x54	a2_on	0	12.5401	No	No	Yes	No	8	6
75	3x25	E2	a2_on	6.38162	13.1441	No	No	Yes	Yes	9	3
76	3x25	E2x50	a2_on	5.58557	12.1266	No	No	No	No	9	9
77	E1x50	E2x50	a2_on	3.7906	10.7838	Yes	Yes	No	No	7	9
78	5x43	Lig	a2_on	0	19.3467	No	Yes	Yes	Yes	5	0
79	5x43	5x461	a2_on	0	17.1909	No	Yes	Yes	Yes	5	5
80	3x43	6x44	a2_on	7.60105	13.4647	No	Yes	Yes	Yes	8	9
81	5x54	6x44	a2_on	0	33.6291	No	No	Yes	Yes	8	9
82	3x43	7x53	a2_on	0	28.0072	No	Yes	Yes	Yes	8	9
83	5x44	6x52	a2_on	6.69916	12.2892	Yes	Yes	Yes	No	5	6
84	5x54	5x58	a2_on	0	47.7257	No	No	No	Yes	8	9
85	3x49	I2x53	a2_on	5.65613	16.2756	Yes	No	Yes	Yes	9	7
86	5x61	6x37	a2_on	0	14.984	No	No	No	No	9	8
87	I2x53	I2x57	a2_on	0.244768	11.7688	Yes	Yes	Yes	No	7	7
88	3x52	I2x57	a2_on	9.66725	10.1148	No	No	Yes	No	5	7
89	2x42	4x42	a2_on	0	13.4136	Yes	Yes	No	No	7	7
90	4x39	4x42	a2_on	0	11.7688	No	No	No	No	1	7
91	4x38	4x39	a2_on	5.8127	10.1148	No	No	No	No	7	1
92	6x55	Lig	a2_on	5.37388	16.559	No	No	Yes	Yes	5	0
93	5x37	6x55	a2_on	4.6506	17.2002	No	No	No	No	4	5
94	5x37	6x59	a2_on	8.76535	15.7924	No	No	Yes	Yes	4	3
95	5x51	6x44	a2_on	0	10.598	No	No	Yes	Yes	6	9
96	5x62	6x37	a2_on	0	39.1906	No	Yes	No	No	5	8
97	5x62	6x30	a2_on	0	32.8625	No	Yes	No	Yes	5	7
98	6x59	6x60	a2_on	3.56127	10.0637	Yes	Yes	Yes	No	3	6
99	7x31	7x35	a2_on	1.06728	19.1284	No	No	No	No	3	3
100	6x26	6x30	a2_on	5.14675	12.2706	No	No	No	Yes	5	7
101	3x43	7x49	a2_on	0	37.9408	No	Yes	Yes	Yes	8	9
102	3x43	5x54	a2_on	0	15.2302	No	Yes	No	No	8	8
103	5x58	7x53	a2_on	0	16.0247	No	Yes	Yes	Yes	9	9

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
1x35	1x39	Shared	14.927	27.3575	0	1	2	2
1x35	7x35	Shared	14.795	14.2175	0	1	2	1
1x39	2x57	Shared	7.515	4.2725	4	1	2	2
1x39	7x42	Shared	12.433	8.46125	4	1	2	1
2x57	7x42	Shared	9.147	7.455	4	1	2	1
E1x51	E2	Shared	13.87	0.80875	0	0	2	1
3x22	E2	Shared	15.175	14.6575	0	0	2	1
3x23	E2	Shared	5.157	1.48875	1	0	2	1
3x25	E2	Shared	4.1	4.2725	1	1	2	1
3x26	E2	Shared	13.873	9.97125	0	1	2	1
3x33	5x39	Shared	3.635	3.51875	1	1	2	2
3x33	5x40	a2_off	3.958	0	1	1	2	1
3x33	5x43	Shared	6.73	5.66125	1	1	2	1
3x36	6x48	a2_off	8.946	0	0	0	1	1
3x40	6x44	Shared	6.028	3.76625	0	1	2	2
5x36	E2	Shared	20.874	6.8925	1	1	2	1
5x38	E2	a2_off	9.831	0	1	0	2	1
5x39	E2	Shared	12.509	7.0175	1	1	2	1
5x42	E2	Shared	5.214	4.26	1	1	2	1
E2	E2	Shared	65.071	8.41	1	1	1	1
E2	E2x51	Shared	13.044	11.785	1	1	1	2
E2	E2x52	Shared	13.557	13.64	1	1	1	1
5x40	E2x52	Shared	5.597	4.51125	1	1	1	1
E2x52	Lig	Shared	31.103	43.2337	1	1	1	0
5x37	E2	a2_off	5.414	0	1	0	2	1
E2	E3	a2_off	9.234	0	1	1	1	1
E2	Lig	Shared	6.549	7.05375	1	1	1	0
5x36	5x38	Shared	4.401	3.335	1	1	2	2
5x37	6x55	Shared	7.149	4.90875	1	0	2	1
5x39	5x40	Shared	3.83	3.14125	1	1	2	1
5x39	5x42	Shared	9.596	6.83625	1	1	2	2
5x39	5x43	Shared	6.86	6.3975	1	1	2	1
5x40	Lig	Shared	5.101	5.98625	1	1	1	0
5x42	5x461	a2_off	3.769	0	1	1	2	2
5x43	6x52	a2_off	3.573	0	1	1	1	1
5x44	5x47	Shared	3.406	4.9125	1	1	2	2
5x44	6x52	Shared	24.89	15.7	1	1	2	1
5x47	6x52	Shared	6.505	7.95625	1	1	2	1
6x44	6x48	Shared	13.33	9.5225	1	1	2	1
6x44	7x45	a2_off	8.338	0	1	1	2	2
6x48	7x41	Shared	11.936	5.095	1	1	1	2
6x48	7x45	Shared	3.729	11.4412	1	1	1	2
6x48	Lig	Shared	5.333	6.0775	1	1	1	0
6x51	Lig	Shared	15.555	7.99625	0	0	1	0
6x52	Lig	Shared	5.87	4.7575	1	1	1	0
6x55	Lig	Shared	10.507	6.43	0	1	1	0
6x58	E3	Shared	9.994	2.65125	0	0	2	1
6x61	E3	Shared	11.341	3.8475	0	3	2	1
7x34	E3	a2_off	5.579	0	1	0	1	1
7x31	7x35	Shared	6.799	4.69	0	0	2	1
7x34	Lig	Shared	4.67	4.11625	1	0	1	0
7x35	Lig	a2_off	4.406	0	0	0	1	0
7x38	7x42	Shared	3.847	4.31125	0	1	1	1
7x38	Lig	Shared	13.11	9.83375	0	1	1	0
7x41	7x42	Shared	3.623	3.4825	0	0	2	1
E3	Lig	a2_off	4.686	0	1	3	1	0
6x54	7x34	Shared	3.355	2.25	0	0	2	1
2x56	3x32	a2_off	3.221	0	0	0	2	1
6x51	7x37	Shared	3.151	2.8475	0	0	1	2
2x60	7x42	Shared	2.93	2.37875	0	0	2	1
3x29	E2x52	a2_off	2.493	0	0	0	2	1
4x63	E2	Shared	1.868	0.85	0	0	2	1
1x35	7x38	a2_on	0	10.7313	0	1	2	1
1x35	7x42	a2_on	0	4.355	0	1	2	1
1x39	7x38	a2_on	0	3.2475	4	1	2	1
3x36	Lig	a2_on	0	10.275	0	0	1	0
3x40	6x48	a2_on	0	14.9763	0	1	2	1
5x40	5x43	a2_on	0	5.0825	1	1	1	1
5x40	6x55	a2_on	0	3.8575	1	1	1	1
5x43	5x461	a2_on	0	4.525	1	1	1	2
5x43	Lig	a2_on	0	3.12125	1	1	1	0
6x51	7x41	a2_on	0	3.31875	0	0	1	2
E3	E3	a2_on	0	4.89375	1	3	1	1
7x30	E3	a2_on	0	3.86375	6	3	2	1
7x42	Lig	a2_on	0	6.415	4	1	1	0
6x57	E3	a2_on	0	3.025	0	0	2	1
1x33	7x35	a2_on	0	2.67	0	0	2	1
3x29	E2	a2_on	0	2.3375	0	0	2	1
3x32	Lig	a2_on	0	1.96375	0	0	1	0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	a2_off	a2a_off
	a2_on	a2a_on a2b_on

Network Difference
Value	a2_off	a2_on
I_min	3.36	3.04625
Number of Linked Nodes	271	260
Number of Specific Nodes	13 (4.80%)	2 (0.77%)
Number of Shared Nodes	258 (95.20%)	258 (99.23%)
Number of Links	308	293
Number of Specific Links	127 (41.23%)	112 (38.23%)
Number of Shared Links	181 (58.77%)	181 (61.77%)
Number of Hubs	40	35
Number of Specific Hubs	16 (40.00%)	11 (31.43%)
Number of Shared Hubs	24 (60.00%)	24 (68.57%)
Average % Shared Neighbours (Jaccard)	46.99
Average % Shared Neighbours (Otsuka)	56.27
Average % Shared Neighbours (Overlap Coefficient)	65.89
Average % Shared Cliques (k3-6)	55.49
Graphlets Similarity	0.643706

Paths Difference
Value	a2_off	a2_on
Number Of Nodes in MetaPath	51	62
Specific Nodes in MetaPath	23 (45.10%)	34 (54.84%)
Shared Nodes in MetaPath	258 (95.20%)	258 (95.20%)
Number Of Links MetaPath	52	67
Specific Links in MetaPath	36 (69.23%)	51 (76.12%)
Shared Links in MetaPath	181 (58.77%)	181 (58.77%)
Number of Shortest Paths	70307	49725
Length Of Smallest Path	3	3
Average Path Length	15.3937	12.8416
Length of Longest Path	38	29
Minimum Path Strength	0.386	0.51625
Average Path Strength	6.03495	5.9361
Maximum Path Strength	20.621	21.4292
Minimum Path Correlation	0.703	0.7
Average Path Correlation	0.915377	0.918084
Maximum Path Correlation	0.99	0.98875
Minimum % Of Corr. Nodes	3.125	3.7037
Average % Of Corr. Nodes	41.5338	43.6435
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	45.3561	44.233
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download a2_off_on.zip<

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