psnGPCR

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Orange: nodes, hubs and links specific of a2a_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of a2a_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	a2a_off Int. Strength	a2a_on Int. Strength	a2a_off Hub1?	a2a_on Hub1?	a2a_off Hub2?	a2a_on Hub2?	ConSurf1	ConSurf2
1	1x39	2x57	a2a_off	7.515	0	Yes	Yes	Yes	Yes	6	6
2	1x39	7x39	a2a_off	4.847	0	Yes	Yes	No	No	6	5
3	1x52	8x57	a2a_off	3.995	0	No	No	No	No	6	6
4	1x53	7x53	a2a_off	4.798	0	No	No	Yes	Yes	9	9
5	1x55	1x59	a2a_off	6.833	0	No	No	No	No	4	5
6	1x55	8x57	a2a_off	9.864	0	No	No	No	No	4	6
7	1x55	8x61	a2a_off	3.809	0	No	No	No	No	4	4
8	1x59	8x57	a2a_off	3.422	0	No	No	No	No	5	6
9	1x60	I1x49	a2a_off	9.672	0	Yes	Yes	No	No	6	5
10	1x60	8x49	a2a_off	8.151	0	Yes	Yes	Yes	No	6	6
11	I1x48	I1x51	a2a_off	3.177	0	No	No	No	No	5	7
12	2x38	I2x57	a2a_off	4.489	0	No	No	Yes	No	6	7
13	2x38	4x42	a2a_off	3.394	0	No	No	No	No	6	7
14	2x39	3x49	a2a_off	9.395	0	No	No	Yes	No	8	9
15	2x39	3x50	a2a_off	8.15	0	No	No	Yes	No	8	9
16	2x40	2x43	a2a_off	5.617	0	Yes	Yes	No	No	8	8
17	2x42	3x45	a2a_off	8.459	0	Yes	Yes	No	No	7	7
18	2x42	3x46	a2a_off	3.517	0	Yes	Yes	No	No	7	8
19	2x42	4x46	a2a_off	6.28	0	Yes	Yes	No	No	7	8
20	2x43	7x53	a2a_off	7.57	0	No	No	Yes	Yes	8	9
21	2x45	4x50	a2a_off	6.18	0	No	No	No	No	9	9
22	2x46	3x39	a2a_off	3.51	0	No	Yes	No	No	9	9
23	2x53	3x35	a2a_off	3.874	0	No	No	No	Yes	6	7
24	2x54	2x57	a2a_off	3.173	0	No	No	Yes	Yes	7	6
25	2x56	3x32	a2a_off	3.221	0	No	No	No	No	6	6
26	2x59	3x28	a2a_off	12.81	0	No	No	No	No	5	6
27	2x62	E1x50	a2a_off	4.02	0	No	No	Yes	No	5	7
28	2x63	E2x50	a2a_off	3.599	0	No	Yes	No	No	4	9
29	E1x51	E2.C159	a2a_off	7.28	0	No	No	No	No	2	3
30	E1x51	E2.Q163	a2a_off	4.119	0	No	No	No	No	2	3
31	3x22	E2.V164	a2a_off	4.099	0	No	No	No	No	3	4
32	3x23	E2.C146	a2a_off	3.243	0	No	No	No	No	2	1
33	3x27	3x31	a2a_off	5.465	0	No	No	Yes	No	4	5
34	3x27	4x58	a2a_off	3.287	0	No	No	No	No	4	3
35	3x30	3x33	a2a_off	3.329	0	No	No	Yes	No	5	4
36	3x31	3x35	a2a_off	8.89	0	Yes	No	No	Yes	5	7
37	3x33	5x40	a2a_off	3.958	0	Yes	No	Yes	Yes	4	6
38	3x36	6x48	a2a_off	8.946	0	No	No	Yes	Yes	6	8
39	3x37	3x40	a2a_off	3.84	0	Yes	Yes	No	No	5	7
40	3x39	6x44	a2a_off	4.772	0	No	No	Yes	Yes	9	9
41	3x41	4x53	a2a_off	3.565	0	Yes	No	No	No	5	7
42	3x43	6x41	a2a_off	3.803	0	No	Yes	No	No	8	8
43	3x44	5x54	a2a_off	4.1	0	No	No	No	No	7	8
44	3x46	6x37	a2a_off	4.483	0	No	No	No	No	8	8
45	3x49	3x50	a2a_off	8.577	0	Yes	No	Yes	No	9	9
46	3x49	I2x57	a2a_off	4.38	0	Yes	No	Yes	No	9	7
47	3x50	3x53	a2a_off	4.7	0	Yes	No	No	No	9	8
48	3x50	I2x53	a2a_off	3.398	0	Yes	No	Yes	Yes	9	7
49	3x51	5x61	a2a_off	4.959	0	No	No	No	No	8	9
50	3x52	I2x57	a2a_off	3.532	0	No	No	Yes	No	5	7
51	3x54	6x30	a2a_off	8.335	0	No	No	No	No	8	7
52	4x56	5x461	a2a_off	5.566	0	No	No	Yes	No	4	5
53	4x59	5x39	a2a_off	5.994	0	No	No	Yes	Yes	6	6
54	5x36	E2.W143	a2a_off	6.757	0	Yes	No	Yes	No	4	5
55	5x38	E2.W143	a2a_off	9.831	0	No	No	Yes	No	4	5
56	5x39	E2.W143	a2a_off	10.997	0	Yes	Yes	Yes	No	6	5
57	E2.C146	E2.N144	a2a_off	8.032	0	No	No	No	No	1	4
58	5x36	E2.N145	a2a_off	10.424	0	Yes	No	No	No	4	4
59	E2.E151	E2.P149	a2a_off	3.931	0	No	No	No	No	2	5
60	E2.K150	E2.K153	a2a_off	4.31	0	No	No	No	No	3	4
61	E2.D170	E2.K150	a2a_off	5.946	0	No	No	No	No	4	3
62	E2.D170	E2.K153	a2a_off	4.7	0	No	No	No	No	4	4
63	E2.G160	E2.Q163	a2a_off	4.112	0	No	No	No	No	1	3
64	5x37	E2.E169	a2a_off	5.414	0	No	No	No	No	4	3
65	E2.E169	E3.H264	a2a_off	9.234	0	No	No	Yes	No	3	2
66	5x41	5x45	a2a_off	4.061	0	No	No	Yes	No	5	4
67	5x41	6x60	a2a_off	3.275	0	No	No	Yes	No	5	6
68	5x411	5x45	a2a_off	3.303	0	No	No	Yes	No	5	4
69	5x411	6x60	a2a_off	5.674	0	No	No	Yes	No	5	6
70	5x42	5x461	a2a_off	3.769	0	No	Yes	Yes	No	4	5
71	5x43	6x52	a2a_off	3.573	0	No	Yes	Yes	Yes	5	6
72	5x44	5x45	a2a_off	6.644	0	Yes	No	Yes	No	5	4
73	5x45	6x60	a2a_off	4.29	0	Yes	No	Yes	No	4	6
74	5x54	6x41	a2a_off	3.838	0	No	No	No	No	8	8
75	5x58	6x38	a2a_off	6.006	0	No	Yes	No	No	9	5
76	5x62	6x35	a2a_off	5.085	0	No	Yes	No	No	5	7
77	5x68	6x27	a2a_off	5.19	0	Yes	No	No	No	6	4
78	5x69	6x27	a2a_off	6.781	0	No	No	No	No	5	4
79	6x24	6x28	a2a_off	4.671	0	Yes	No	No	No	3	4
80	6x31	6x35	a2a_off	3.187	0	No	No	No	No	5	7
81	6x32	7x56	a2a_off	9.817	0	No	No	Yes	No	8	7
82	6x35	7x56	a2a_off	4.087	0	No	No	Yes	No	7	7
83	6x40	7x49	a2a_off	6.797	0	No	No	Yes	Yes	8	9
84	6x40	7x52	a2a_off	6.477	0	No	No	No	Yes	8	8
85	6x44	7x45	a2a_off	8.338	0	Yes	Yes	No	Yes	9	9
86	6x47	7x40	a2a_off	3.174	0	No	No	No	No	8	7
87	6x54	7x34	a2a_off	3.355	0	No	No	No	No	5	4
88	6x56	6x60	a2a_off	3.911	0	No	No	Yes	No	6	6
89	6x59	6x60	a2a_off	8.898	0	Yes	No	Yes	No	3	6
90	6x61	E3.C262	a2a_off	7.28	0	No	No	No	No	4	1
91	7x34	E3.H264	a2a_off	3.808	0	No	No	Yes	No	4	2
92	7x30	7x32	a2a_off	10.945	0	No	No	No	No	3	1
93	7x32	7x33	a2a_off	7.629	0	No	No	Yes	No	1	4
94	7x35	Lig	a2a_off	4.406	0	Yes	Yes	Yes	Yes	3	0
95	7x49	7x53	a2a_off	5.114	0	Yes	Yes	Yes	Yes	9	9
96	7x53	8x50	a2a_off	4.951	0	Yes	Yes	Yes	Yes	9	8
97	8x48	8x51	a2a_off	4.584	0	No	No	No	No	4	8
98	8x48	8x52	a2a_off	7.594	0	No	No	No	No	4	4
99	8x50	8x54	a2a_off	6.002	0	Yes	Yes	Yes	No	8	6
100	8x51	8x55	a2a_off	5.117	0	No	No	No	No	8	5
101	8x55	8x59	a2a_off	10.235	0	No	No	No	No	5	5
102	8x60	8x61	a2a_off	4.322	0	No	No	No	No	4	4
103	2x64	7x35	a2a_off	3.307	0	No	No	Yes	Yes	3	3
104	E3.H264	Lig	a2a_off	4.686	0	Yes	No	Yes	Yes	2	0
105	5x69	6x24	a2a_off	3.035	0	No	No	Yes	No	5	3
106	6x21	6x24	a2a_off	3.024	0	No	No	Yes	No	4	3
107	4x56	4x57	a2a_off	2.999	0	No	No	No	No	4	6
108	6x54	7x33	a2a_off	2.996	0	No	No	Yes	No	5	4
109	3x54	5x61	a2a_off	2.942	0	No	No	No	No	8	9
110	1x42	2x57	a2a_off	2.793	0	Yes	No	Yes	Yes	7	6
111	6x25	6x29	a2a_off	2.754	0	No	No	No	No	4	6
112	2x41	4x43	a2a_off	2.747	0	No	No	No	No	5	3
113	2x49	4x50	a2a_off	2.72	0	No	No	No	No	8	9
114	6x49	6x53	a2a_off	2.711	0	No	No	No	No	6	5
115	5x48	5x52	a2a_off	2.629	0	No	No	No	No	4	3
116	5x57	5x61	a2a_off	2.611	0	No	No	No	No	7	9
117	1x38	1x42	a2a_off	2.611	0	No	No	Yes	No	5	7
118	3x29	E2x52	a2a_off	2.493	0	No	No	Yes	Yes	5	4
119	7x54	8x54	a2a_off	2.493	0	No	No	Yes	No	7	6
120	E2.G147	E2.Q148	a2a_off	2.465	0	No	No	No	No	3	3
121	1x58	1x59	a2a_off	2.393	0	No	No	No	No	3	5
122	1x44	1x48	a2a_off	2.384	0	No	No	No	No	4	5
123	5x51	6x45	a2a_off	2.367	0	No	No	No	No	6	5
124	E2.N154	E2.V164	a2a_off	2.365	0	No	No	No	No	0	4
125	E1x51	E2.Q157	a2a_off	2.29	0	No	No	Yes	No	2	3
126	5x47	5x51	a2a_off	2.235	0	No	No	No	No	7	6
127	6x45	6x49	a2a_off	2.207	0	No	No	No	No	5	6
128	I2x51	I2x52	a2a_off	2.186	0	No	No	No	No	6	5
129	6x61	E3.D261	a2a_off	2.181	0	No	No	No	No	4	1
130	4x48	4x52	a2a_off	2.139	0	No	No	No	No	3	4
131	6x53	6x57	a2a_off	2.134	0	No	No	No	No	5	4
132	1x57	8x50	a2a_off	2.096	0	No	No	Yes	Yes	7	8
133	E2.E151	E2.H155	a2a_off	2.091	0	No	No	No	No	2	3
134	5x65	6x31	a2a_off	2.039	0	No	No	No	No	8	5
135	2x38	4x39	a2a_off	2.024	0	No	No	No	No	6	1
136	2x41	4x39	a2a_off	1.885	0	No	No	No	No	5	1
137	1x46	7x46	a2a_off	1.881	0	No	No	No	No	7	9
138	1x54	2x44	a2a_off	1.881	0	No	No	No	No	7	5
139	6x26	6x30	a2a_off	1.833	0	No	No	No	No	5	7
140	3x54	5x68	a2a_off	1.783	0	No	No	Yes	No	8	6
141	7x47	7x51	a2a_off	1.703	0	No	No	No	No	7	6
142	E2.A165	E2.Q157	a2a_off	1.669	0	No	No	Yes	No	3	3
143	8x54	8x58	a2a_off	1.634	0	Yes	No	No	No	6	6
144	2x41	I1x51	a2a_off	1.466	0	No	No	No	No	5	7
145	6x22	6x26	a2a_off	1.422	0	No	No	No	No	1	5
146	E2.P149	E2.Q148	a2a_off	1.422	0	No	No	No	No	5	3
147	1x30	1x31	a2a_off	1.4	0	Yes	No	No	No	4	5
148	5x62	5x66	a2a_off	1.389	0	No	Yes	No	No	5	5
149	8x56	8x60	a2a_off	1.377	0	No	No	No	No	4	4
150	8x49	8x52	a2a_off	1.273	0	Yes	No	No	No	6	4
151	1x29	1x33	a2a_off	1.24	0	No	No	No	No	5	4
152	1x32	1x36	a2a_off	1.24	0	No	No	No	No	4	6
153	5x67	6x27	a2a_off	1.215	0	No	No	No	No	4	4
154	E2.A165	E2.K153	a2a_off	1.125	0	No	No	No	No	3	4
155	3x55	5x64	a2a_off	1.105	0	No	No	No	No	6	6
156	E2.A154	E2.C159	a2a_off	1.083	0	No	No	No	No	1	3
157	E2.P149	E2.V164	a2a_off	1.062	0	No	No	No	No	5	4
158	6x22	6x25	a2a_off	1.054	0	No	No	No	No	1	4
159	4x59	4x62	a2a_off	1.032	0	No	No	No	No	6	4
160	8x58	8x63	a2a_off	0.998	0	No	No	No	No	6	0
161	1x29	1x30	a2a_off	0.876	0	No	No	Yes	No	5	4
162	6x43	6x46	a2a_off	0.828	0	No	No	No	No	7	5
163	E2.E161	E2.G160	a2a_off	0.818	0	No	No	No	No	3	1
164	8x58	8x62	a2a_off	0.769	0	No	No	No	No	6	6
165	4x43	4x44	a2a_off	0.759	0	No	No	No	No	3	3
166	E2.Q157	E2.S156	a2a_off	0.721	0	Yes	No	No	No	3	4
167	5x72	I3.Q214	a2a_off	0.68	0	No	No	No	No	0	0
168	I3.L216	I3.Q214	a2a_off	0.665	0	No	No	No	No	0	0
169	5x72	6x24	a2a_off	0.62	0	No	No	Yes	No	0	3
170	8x61	8x64	a2a_off	0.564	0	No	No	No	No	4	0
171	6x23	6x26	a2a_off	0.503	0	No	No	No	No	3	5
172	1x27	1x30	a2a_off	0.503	0	No	No	Yes	No	0	4
173	1x30	1x32	a2a_off	0.46	0	Yes	No	No	No	4	4
174	3x50	6x33	a2a_off	0.415	0	Yes	No	No	No	9	8
175	8x64	8x65	a2a_off	0.35	0	No	No	No	No	0	0
176	I2x54	I2x55	a2a_off	0.339	0	No	No	No	No	5	5
177	5x68	I3.M211	a2a_off	0.272	0	Yes	No	No	No	6	0
178	5x70	5x73	a2a_off	0.27	0	No	No	No	No	0	0
179	5x66	I3.K209	a2a_off	0.248	0	No	No	No	No	5	0
180	I3.G218	I3.P217	a2a_off	0.203	0	No	No	No	No	0	0
181	1x27	1x28	a2a_off	0.195	0	No	No	No	No	0	6
182	I3.G218	I3.L216	a2a_off	0.171	0	No	No	No	No	0	0
183	E2.E161	E2.G162	a2a_off	0.164	0	No	No	No	No	3	4
184	E2.G158	E2.Q157	a2a_off	0.164	0	No	No	Yes	No	2	3
185	I3.P215	I3.Q214	a2a_off	0.158	0	No	No	No	No	0	0
186	4x52	4x55	a2a_off	0.158	0	No	No	No	No	4	4
187	5x68	5x71	a2a_off	0.128	0	Yes	No	No	No	6	0
188	5x73	6x24	a2a_off	0.116	0	No	No	Yes	No	0	3
189	1x35	1x39	Shared	14.927	38.16	No	Yes	Yes	Yes	5	6
190	1x35	2x64	Shared	4.326	3.82	No	Yes	No	No	5	3
191	1x35	7x35	Shared	14.795	13.9	No	Yes	Yes	Yes	5	3
192	1x36	2x61	Shared	5.74	5.89	No	No	No	No	6	6
193	1x39	2x61	Shared	4.648	9.56	Yes	Yes	No	No	6	6
194	1x39	7x42	Shared	12.433	6.15	Yes	Yes	Yes	Yes	6	6
195	1x43	2x57	Shared	5.035	4.87	No	No	Yes	Yes	6	6
196	1x45	7x47	Shared	4.619	5.96	No	No	No	No	5	7
197	1x47	2x54	Shared	3.353	3.53	No	No	No	No	6	7
198	1x47	2x55	Shared	3.224	3.07	No	No	No	No	6	5
199	1x49	7x50	Shared	4.06	4.06	No	No	No	Yes	9	9
200	1x50	2x47	Shared	4.69	4.69	Yes	Yes	No	No	9	9
201	1x50	2x50	Shared	10.366	14.81	Yes	Yes	Yes	Yes	9	9
202	1x50	7x50	Shared	9.933	8.15	Yes	Yes	No	Yes	9	9
203	1x51	2x51	Shared	3.378	4.61	No	No	No	No	4	7
204	1x52	8x54	Shared	10.229	14.61	No	No	Yes	No	6	6
205	1x53	7x50	Shared	3.53	1.77	No	No	No	Yes	9	9
206	1x56	8x53	Shared	3.527	5.03	No	No	No	Yes	8	7
207	1x57	2x44	Shared	4.489	4.81	No	No	No	No	7	5
208	1x60	I1x50	Shared	9.336	9.61	Yes	Yes	Yes	Yes	6	8
209	1x60	8x53	Shared	7.748	4.39	Yes	Yes	No	Yes	6	7
210	8x49	I1x49	Shared	11.042	15.77	Yes	No	No	No	6	5
211	2x40	I1x50	Shared	3.709	5.49	Yes	Yes	Yes	Yes	8	8
212	8x49	I1x50	Shared	4.906	9.28	Yes	No	Yes	Yes	6	8
213	8x50	I1x50	Shared	10.229	10.96	Yes	Yes	Yes	Yes	8	8
214	8x53	I1x50	Shared	3.98	4.42	No	Yes	Yes	Yes	7	8
215	2x37	2x39	Shared	4.093	10.24	No	No	No	No	7	8
216	2x37	2x40	Shared	12.668	13.62	No	No	Yes	Yes	7	8
217	2x40	8x50	Shared	6.042	4.83	Yes	Yes	Yes	Yes	8	8
218	2x42	4x45	Shared	3.516	7.54	Yes	Yes	No	No	7	5
219	2x45	3x42	Shared	3.912	3.26	No	No	No	No	9	7
220	2x45	4x46	Shared	5.57	10.84	No	No	No	No	9	8
221	2x46	7x49	Shared	4.533	13.73	No	Yes	Yes	Yes	9	9
222	2x50	3x39	Shared	5.065	4.42	Yes	Yes	No	No	9	9
223	2x50	7x46	Shared	9.422	7.36	Yes	Yes	No	No	9	9
224	2x50	7x49	Shared	4.039	10.77	Yes	Yes	Yes	Yes	9	9
225	2x52	3x35	Shared	4.775	4.73	No	No	No	Yes	6	7
226	2x53	2x56	Shared	5.09	5.09	No	No	No	No	6	6
227	2x53	7x46	Shared	8.081	9.7	No	No	No	No	6	9
228	2x551	3x31	Shared	3.653	3.65	No	No	Yes	No	5	5
229	2x57	2x58	Shared	3.39	5.08	Yes	Yes	No	No	6	8
230	2x57	7x42	Shared	9.147	7.95	Yes	Yes	Yes	Yes	6	6
231	2x59	3x31	Shared	6.002	4.29	No	No	Yes	No	5	5
232	E1x50	E1x52	Shared	4.577	4.16	Yes	No	No	No	7	6
233	E1x50	E2x50	Shared	7.962	6.98	Yes	No	No	No	7	9
234	3x22	E2.C146	Shared	7.28	5.46	No	No	No	No	3	1
235	3x25	E2x50	Shared	7.28	7.28	No	No	No	No	9	9
236	3x25	E2.V171	Shared	4.1	3.42	No	No	No	No	9	4
237	3x26	4x61	Shared	3.25	2.83	No	Yes	No	No	6	5
238	3x26	E2.N144	Shared	7.005	1.37	No	Yes	No	No	6	4
239	3x26	E2.V171	Shared	3.278	5.96	No	Yes	No	No	6	4
240	3x27	4x61	Shared	4.478	3.73	No	No	No	No	4	5
241	3x30	4x60	Shared	5.65	5.65	No	No	No	No	5	5
242	3x33	5x39	Shared	3.635	3.52	Yes	No	Yes	Yes	4	6
243	3x33	5x43	Shared	6.73	10.98	Yes	No	No	Yes	4	5
244	3x34	4x54	Shared	10.49	7.87	No	No	No	No	4	3
245	3x34	4x58	Shared	4.172	2.98	No	No	No	No	4	3
246	3x37	3x41	Shared	8.434	8.2	Yes	Yes	Yes	No	5	5
247	3x37	4x53	Shared	5.49	4.33	Yes	Yes	No	No	5	7
248	3x37	4x56	Shared	10.569	10.98	Yes	Yes	No	No	5	4
249	3x37	5x461	Shared	5.951	10.68	Yes	Yes	Yes	No	5	5
250	3x38	4x50	Shared	18.53	4.94	No	Yes	No	No	6	9
251	3x38	4x53	Shared	4.564	4.89	No	Yes	No	No	6	7
252	3x40	5x50	Shared	3.39	3.39	No	No	No	No	7	8
253	3x40	6x44	Shared	6.028	5.02	No	No	Yes	Yes	7	9
254	3x41	4x49	Shared	9.638	2.79	Yes	No	No	No	5	7
255	3x41	4x52	Shared	3.29	6.09	Yes	No	No	No	5	4
256	3x43	6x44	Shared	4.992	7.31	No	Yes	Yes	Yes	8	9
257	3x44	3x48	Shared	4.139	2.85	No	No	No	No	7	6
258	3x47	5x58	Shared	6.138	6.67	No	No	No	Yes	9	9
259	3x49	I2x53	Shared	10.341	5.75	Yes	No	Yes	Yes	9	7
260	3x51	3x55	Shared	8.721	10.29	No	No	No	No	8	6
261	3x51	5x60	Shared	9.158	11.32	No	No	No	No	8	5
262	3x53	I2x53	Shared	3.602	8.01	No	No	Yes	Yes	8	7
263	3x56	I2x52	Shared	6.765	5.01	No	No	No	No	5	5
264	I2x53	I2x54	Shared	3.837	3.49	Yes	Yes	No	No	7	5
265	I2x53	I2x57	Shared	14.385	10.09	Yes	Yes	Yes	No	7	7
266	4x38	4x41	Shared	8.794	5.17	No	No	No	No	7	5
267	4x58	4x61	Shared	5.938	2.83	No	No	No	No	3	5
268	4x59	4x60	Shared	3.849	5.25	No	No	No	No	6	5
269	4x60	5x39	Shared	15.856	12.52	No	No	Yes	Yes	5	6
270	5x42	E2.W143	Shared	5.214	5.01	No	Yes	Yes	No	4	5
271	E2.D170	E2x51	Shared	9.634	8.14	No	No	No	No	4	4
272	E2.V172	E2x52	Shared	11.799	9.18	No	No	Yes	Yes	3	4
273	5x40	E2x52	Shared	5.597	4.98	Yes	Yes	Yes	Yes	6	4
274	E2x52	Lig	Shared	31.103	54.67	Yes	Yes	Yes	Yes	4	0
275	E2.E169	Lig	Shared	6.549	9.15	No	No	Yes	Yes	3	0
276	5x36	E2.V172	Shared	3.53	3.53	Yes	No	No	No	4	3
277	5x40	E2.V172	Shared	3.192	3.04	Yes	Yes	No	No	6	3
278	5x36	5x38	Shared	4.401	4.89	Yes	No	No	No	4	4
279	5x37	6x55	Shared	7.149	4.21	No	No	No	No	4	5
280	5x37	6x59	Shared	6.592	3.73	No	No	Yes	No	4	3
281	5x39	5x40	Shared	3.83	3.59	Yes	Yes	Yes	Yes	6	6
282	5x39	5x42	Shared	9.596	4.13	Yes	Yes	No	Yes	6	4
283	5x39	5x43	Shared	6.86	10.47	Yes	Yes	No	Yes	6	5
284	5x40	Lig	Shared	5.101	3.91	Yes	Yes	Yes	Yes	6	0
285	5x41	6x59	Shared	7.735	7.87	No	No	Yes	No	5	3
286	5x411	6x59	Shared	7.631	9.28	No	No	Yes	No	5	3
287	5x44	5x47	Shared	3.406	5.24	Yes	No	No	No	5	7
288	5x44	5x48	Shared	7.796	6.09	Yes	No	No	No	5	4
289	5x44	6x52	Shared	24.89	13.58	Yes	No	Yes	Yes	5	6
290	5x47	6x52	Shared	6.505	6.92	No	No	Yes	Yes	7	6
291	5x49	5x50	Shared	4.061	3.53	No	No	No	No	5	8
292	5x55	5x59	Shared	3.182	1.38	No	No	No	No	4	4
293	5x58	6x37	Shared	5.286	7.03	No	Yes	No	No	9	8
294	6x36	7x56	Shared	12.916	7.91	No	No	Yes	No	8	7
295	6x39	7x56	Shared	4.759	2.51	No	No	Yes	No	6	7
296	6x40	7x53	Shared	3.63	4.84	No	No	Yes	Yes	8	9
297	6x44	6x48	Shared	13.33	7.02	Yes	Yes	Yes	Yes	9	8
298	6x47	7x45	Shared	8.505	4.72	No	No	No	Yes	8	9
299	6x48	7x41	Shared	11.936	4.94	Yes	Yes	No	Yes	8	7
300	6x48	7x45	Shared	3.729	13.56	Yes	Yes	No	Yes	8	9
301	6x48	Lig	Shared	5.333	8.65	Yes	Yes	Yes	Yes	8	0
302	6x50	7x40	Shared	3.778	1.64	No	No	No	No	9	7
303	6x51	Lig	Shared	15.555	11.47	No	No	Yes	Yes	5	0
304	6x52	Lig	Shared	5.87	4.44	Yes	Yes	Yes	Yes	6	0
305	6x55	Lig	Shared	10.507	5.69	No	No	Yes	Yes	5	0
306	6x58	E3.H264	Shared	9.994	2.74	No	No	Yes	No	4	2
307	7x30	7x33	Shared	5.422	11.49	No	No	Yes	No	3	4
308	7x31	7x35	Shared	6.799	9.38	No	No	Yes	Yes	3	3
309	7x34	Lig	Shared	4.67	3.91	No	No	Yes	Yes	4	0
310	7x38	7x42	Shared	3.847	3.98	No	Yes	Yes	Yes	4	6
311	7x38	Lig	Shared	13.11	8.87	No	Yes	Yes	Yes	4	0
312	7x41	7x42	Shared	3.623	4.18	No	Yes	Yes	Yes	7	6
313	8x47	8x50	Shared	7.537	11.3	No	No	Yes	Yes	8	8
314	6x51	7x37	Shared	3.151	3.15	No	No	No	No	5	6
315	6x43	7x48	Shared	3.129	5.96	No	No	No	No	7	6
316	1x50	2x51	Shared	3.114	4.25	Yes	Yes	No	No	9	7
317	2x60	7x42	Shared	2.93	2.93	No	No	Yes	Yes	5	6
318	2x66	E2x51	Shared	2.907	1.71	No	No	No	No	4	4
319	2x65	E1x50	Shared	2.853	3.89	No	No	Yes	No	5	7
320	6x43	7x52	Shared	2.851	2.85	No	No	No	Yes	7	8
321	I2x56	I2x57	Shared	2.831	2.98	No	No	Yes	No	4	7
322	3x47	5x57	Shared	2.713	1.7	No	No	No	No	9	7
323	1x36	1x40	Shared	2.708	1.43	No	No	No	No	6	5
324	1x42	7x43	Shared	2.584	3.04	Yes	No	No	No	7	5
325	6x39	7x52	Shared	2.502	1.47	No	No	No	Yes	6	8
326	6x54	E3.A265	Shared	2.433	1.62	No	No	No	No	5	4
327	5x56	5x59	Shared	2.394	1.71	No	No	No	No	4	4
328	5x62	6x34	Shared	2.217	5.55	No	Yes	No	No	5	7
329	2x65	2x66	Shared	2.002	3.64	No	No	No	No	5	4
330	3x52	3x56	Shared	1.911	5.89	No	No	No	No	5	5
331	1x48	1x49	Shared	1.881	1.71	No	No	No	No	5	9
332	6x61	E3.P260	Shared	1.88	1.88	No	No	No	No	4	1
333	4x63	E2.N144	Shared	1.868	1.7	No	No	No	No	4	4
334	4x38	4x39	Shared	1.82	3.64	No	No	No	No	7	1
335	5x49	5x53	Shared	1.788	2.98	No	No	No	No	5	6
336	3x56	I2x50	Shared	1.69	1.69	No	No	No	No	5	8
337	1x34	1x38	Shared	1.6	1.6	No	No	No	No	5	5
338	4x38	4x40	Shared	1.57	1.57	No	No	No	No	7	5
339	1x42	7x47	Shared	1.54	4.61	Yes	No	No	No	7	7
340	5x63	5x66	Shared	1.473	3.64	No	No	No	No	4	5
341	7x51	7x55	Shared	1.443	7.22	No	No	No	No	6	6
342	7x33	7x36	Shared	1.244	1.38	Yes	No	No	No	4	5
343	6x57	E3.C262	Shared	0.978	5.59	No	No	No	No	4	1
344	5x46	5x461	Shared	0.724	1.81	No	No	Yes	No	3	5
345	4x44	4x47	Shared	0.585	1.95	No	No	No	No	3	4
346	5x55	6x41	Shared	0.447	2.98	No	No	No	No	4	8
347	6x42	6x45	Shared	0.39	1.95	No	No	No	No	5	5
348	1x37	1x38	Shared	0.317	1.59	No	No	No	No	4	5
349	3x23	3x24	Shared	0.159	1.59	No	No	No	No	2	6
350	1x33	7x35	a2a_on	0	5.34	No	No	Yes	Yes	4	3
351	1x35	7x38	a2a_on	0	14.51	No	Yes	No	Yes	5	4
352	1x35	7x39	a2a_on	0	7.57	No	Yes	No	No	5	5
353	1x35	7x42	a2a_on	0	8.71	No	Yes	Yes	Yes	5	6
354	1x38	7x39	a2a_on	0	9.62	No	No	No	No	5	5
355	1x39	7x38	a2a_on	0	4.1	Yes	Yes	No	Yes	6	4
356	1x42	7x39	a2a_on	0	3.07	Yes	No	No	No	7	5
357	1x53	7x54	a2a_on	0	5.09	No	No	No	No	9	7
358	1x53	8x50	a2a_on	0	3.93	No	No	Yes	Yes	9	8
359	1x57	2x40	a2a_on	0	10.35	No	No	Yes	Yes	7	8
360	1x59	8x53	a2a_on	0	4.42	No	No	No	Yes	5	7
361	1x60	8x52	a2a_on	0	9.24	Yes	Yes	No	No	6	4
362	2x42	3x49	a2a_on	0	20.3	Yes	Yes	Yes	No	7	9
363	2x46	2x50	a2a_on	0	5.43	No	Yes	Yes	Yes	9	9
364	2x46	3x42	a2a_on	0	4.5	No	Yes	No	No	9	7
365	2x46	3x46	a2a_on	0	4.28	No	Yes	No	No	9	8
366	2x46	7x53	a2a_on	0	3.52	No	Yes	Yes	Yes	9	9
367	2x50	7x50	a2a_on	0	4.83	Yes	Yes	No	Yes	9	9
368	2x53	2x57	a2a_on	0	3.07	No	No	Yes	Yes	6	6
369	2x55	2x551	a2a_on	0	2.98	No	No	No	No	5	5
370	2x551	3x35	a2a_on	0	4.15	No	No	No	Yes	5	7
371	2x56	3x35	a2a_on	0	4.73	No	No	No	Yes	6	7
372	2x60	3x32	a2a_on	0	3.39	No	No	No	No	5	6
373	2x63	3x28	a2a_on	0	4.42	No	Yes	No	No	4	6
374	2x63	3x29	a2a_on	0	3.25	No	Yes	No	No	4	5
375	3x26	3x30	a2a_on	0	3.17	No	Yes	No	No	6	5
376	3x35	3x38	a2a_on	0	3	No	Yes	No	Yes	7	6
377	3x36	Lig	a2a_on	0	12.21	No	No	Yes	Yes	6	0
378	3x40	6x48	a2a_on	0	17.62	No	No	Yes	Yes	7	8
379	3x43	5x54	a2a_on	0	5.65	No	Yes	No	No	8	8
380	3x43	7x45	a2a_on	0	4.12	No	Yes	No	Yes	8	9
381	3x43	7x49	a2a_on	0	5.49	No	Yes	Yes	Yes	8	9
382	3x43	7x53	a2a_on	0	3.52	No	Yes	Yes	Yes	8	9
383	3x44	5x53	a2a_on	0	6.92	No	No	No	No	7	6
384	3x46	7x53	a2a_on	0	6.04	No	No	Yes	Yes	8	9
385	3x50	5x58	a2a_on	0	3.09	Yes	No	No	Yes	9	9
386	3x50	7x53	a2a_on	0	8.23	Yes	No	Yes	Yes	9	9
387	3x51	5x57	a2a_on	0	6.31	No	No	No	No	8	7
388	3x52	I2x56	a2a_on	0	4.28	No	No	No	No	5	4
389	3x55	5x60	a2a_on	0	4.26	No	No	No	No	6	5
390	4x52	4x56	a2a_on	0	7.14	No	No	No	No	4	4
391	4x56	5x42	a2a_on	0	5.02	No	No	No	Yes	4	4
392	4x59	5x42	a2a_on	0	5.19	No	No	No	Yes	6	4
393	E2.E169	E2x52	a2a_on	0	5.83	No	No	Yes	Yes	3	4
394	5x37	6x58	a2a_on	0	3.01	No	No	No	No	4	4
395	5x40	5x43	a2a_on	0	7.01	Yes	Yes	No	Yes	6	5
396	5x40	6x52	a2a_on	0	3.94	Yes	Yes	Yes	Yes	6	6
397	5x40	6x55	a2a_on	0	4.21	Yes	Yes	No	No	6	5
398	5x41	6x56	a2a_on	0	3.42	No	No	No	No	5	6
399	5x43	5x461	a2a_on	0	7.87	No	Yes	Yes	No	5	5
400	5x45	5x49	a2a_on	0	6.55	Yes	No	No	No	4	5
401	5x51	6x44	a2a_on	0	4.87	No	No	Yes	Yes	6	9
402	5x51	6x49	a2a_on	0	4.15	No	No	No	No	6	6
403	5x54	5x58	a2a_on	0	5.99	No	No	No	Yes	8	9
404	5x54	6x44	a2a_on	0	8.71	No	No	Yes	Yes	8	9
405	5x58	6x40	a2a_on	0	6.04	No	Yes	No	No	9	8
406	5x58	6x41	a2a_on	0	5.05	No	Yes	No	No	9	8
407	5x58	7x53	a2a_on	0	4.96	No	Yes	Yes	Yes	9	9
408	5x61	6x37	a2a_on	0	4.28	No	No	No	No	9	8
409	5x62	6x30	a2a_on	0	5.83	No	Yes	No	No	5	7
410	5x69	6x29	a2a_on	0	7.05	No	No	No	No	5	6
411	5x70	6x26	a2a_on	0	3	No	No	No	No	0	5
412	6x27	6x31	a2a_on	0	2.98	No	No	No	No	4	5
413	6x29	6x32	a2a_on	0	5.24	No	No	No	No	6	8
414	6x51	7x41	a2a_on	0	3	No	No	No	Yes	5	7
415	7x34	E3.A265	a2a_on	0	3.22	No	No	No	No	4	4
416	7x40	7x43	a2a_on	0	2.95	No	No	No	No	7	5
417	7x41	Lig	a2a_on	0	4.15	No	Yes	Yes	Yes	7	0
418	7x42	Lig	a2a_on	0	7.99	Yes	Yes	Yes	Yes	6	0
419	7x45	7x49	a2a_on	0	13.62	No	Yes	Yes	Yes	9	9
420	7x52	7x53	a2a_on	0	8.46	No	Yes	Yes	Yes	8	9
421	8x52	8x53	a2a_on	0	9.92	No	No	No	Yes	4	7
422	6x35	6x39	a2a_on	0	2.91	No	No	No	No	7	6
423	6x28	6x31	a2a_on	0	2.87	No	No	No	No	4	5
424	6x60	6x61	a2a_on	0	2.79	Yes	No	No	No	6	4
425	2x42	4x42	a2a_on	0	2.77	Yes	Yes	No	No	7	7
426	5x62	6x33	a2a_on	0	2.77	No	Yes	No	No	5	8
427	6x46	7x40	a2a_on	0	2.77	No	No	No	No	5	7
428	6x28	6x29	a2a_on	0	2.71	No	No	No	No	4	6
429	2x38	2x42	a2a_on	0	2.62	No	No	Yes	Yes	6	7
430	6x57	6x58	a2a_on	0	2.59	No	No	No	No	4	4
431	2x63	E2x52	a2a_on	0	2.51	No	Yes	Yes	Yes	4	4
432	5x66	6x30	a2a_on	0	2.33	No	No	No	No	5	7
433	7x55	8x51	a2a_on	0	2.06	No	No	No	No	6	8
434	1x46	2x54	a2a_on	0	1.95	No	No	No	No	7	7
435	4x39	4x42	a2a_on	0	1.95	No	No	No	No	1	7
436	7x32	7x35	a2a_on	0	1.93	No	No	Yes	Yes	1	3
437	7x30	E3.A265	a2a_on	0	1.87	No	No	No	No	3	4
438	3x34	4x57	a2a_on	0	1.84	No	No	No	No	4	6
439	6x41	6x42	a2a_on	0	1.84	No	No	No	No	8	5
440	1x54	2x47	a2a_on	0	1.81	No	No	No	No	7	9
441	3x45	4x49	a2a_on	0	1.81	No	No	No	No	7	7
442	5x65	6x33	a2a_on	0	1.79	No	No	No	No	8	8
443	E3.C262	E3.S263	a2a_on	0	1.72	No	No	No	No	1	1
444	2x49	3x38	a2a_on	0	1.71	No	No	No	Yes	8	6
445	2x49	3x39	a2a_on	0	1.71	No	No	No	No	8	9
446	2x43	7x54	a2a_on	0	1.7	No	No	No	No	8	7
447	6x49	6x50	a2a_on	0	1.64	No	No	No	No	6	9
448	3x45	4x45	a2a_on	0	1.62	No	No	No	No	7	5
449	3x53	3x54	a2a_on	0	1.62	No	No	No	No	8	8
450	3x54	5x64	a2a_on	0	1.62	No	No	No	No	8	6
451	6x54	7x37	a2a_on	0	1.62	No	No	No	No	5	6
452	3x26	E2.C146	a2a_on	0	1.59	No	Yes	No	No	6	1
453	2x62	2x63	a2a_on	0	1.52	No	No	No	Yes	5	4
454	2x62	3x28	a2a_on	0	1.52	No	No	No	No	5	6
455	3x24	3x27	a2a_on	0	1.51	No	No	No	No	6	4
456	1x60	I1x48	a2a_on	0	1.49	Yes	Yes	No	No	6	5
457	5x69	6x26	a2a_on	0	1.47	No	No	No	No	5	5
458	1x57	I1x51	a2a_on	0	1.43	No	No	No	No	7	7
459	5x68	5x72	a2a_on	0	1.36	Yes	No	No	No	6	0
460	6x27	6x30	a2a_on	0	1.33	No	No	No	No	4	7
461	7x51	7x52	a2a_on	0	1.26	No	No	No	Yes	6	8
462	5x62	6x37	a2a_on	0	1.22	No	Yes	No	No	5	8
463	2x41	4x46	a2a_on	0	1.21	No	No	No	No	5	8

Orange: nodes, hubs and links specific of a2a_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of a2a_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	a2a_off Avg Int. Strength	a2a_on Avg Int. Strength	a2a_off Num Of Links	a2a_on Num Of Links	ConSurf
1	1x30	a2a_off	0.80975	0	4	0	4
2	1x42	a2a_off	2.382	3.57333	4	3	7
3	E1x50	a2a_off	4.853	5.01	4	3	7
4	3x31	a2a_off	6.0025	3.97	4	2	5
5	3x33	a2a_off	4.413	7.25	4	2	4
6	3x41	a2a_off	6.23175	5.69333	4	3	5
7	3x49	a2a_off	8.17325	13.025	4	2	9
8	3x50	a2a_off	5.048	5.66	5	2	9
9	I2x57	a2a_off	5.9234	6.535	5	2	7
10	E2.W143	a2a_off	8.19975	5.01	4	1	5
11	E2.Q157	a2a_off	1.211	0	4	0	3
12	5x36	a2a_off	6.278	4.21	4	2	4
13	5x44	a2a_off	10.684	8.30333	4	3	5
14	5x45	a2a_off	4.5745	6.55	4	1	4
15	5x461	a2a_off	4.0025	6.78667	4	3	5
16	5x68	a2a_off	1.84325	1.36	4	1	6
17	6x24	a2a_off	2.2932	0	5	0	3
18	6x59	a2a_off	7.714	6.96	4	3	3
19	6x60	a2a_off	5.2096	2.79	5	1	6
20	E3.H264	a2a_off	6.9305	2.74	4	1	2
21	7x33	a2a_off	4.32275	6.435	4	2	4
22	7x56	a2a_off	7.89475	5.21	4	2	7
23	8x49	a2a_off	6.343	12.525	4	2	6
24	8x54	a2a_off	5.0895	14.61	4	1	6
25	1x39	Shared	8.874	14.4925	5	4	6
26	1x50	Shared	7.02575	7.975	4	4	9
27	1x60	Shared	8.72675	6.1825	4	4	6
28	I1x50	Shared	6.432	7.952	5	5	8
29	2x40	Shared	7.009	8.5725	4	4	8
30	2x42	Shared	5.443	8.3075	4	4	7
31	2x50	Shared	7.223	7.93667	4	6	9
32	2x57	Shared	5.1755	5.2425	6	4	6
33	3x37	Shared	6.8568	8.5475	5	4	5
34	I2x53	Shared	7.1126	6.835	5	4	7
35	E2x52	Shared	12.748	15.434	4	5	4
36	5x39	Shared	8.10972	6.846	7	5	6
37	5x40	Shared	4.3356	4.38286	5	7	6
38	6x44	Shared	7.492	6.586	5	5	9
39	6x48	Shared	8.6548	10.358	5	5	8
40	6x52	Shared	10.2095	7.22	4	4	6
41	7x35	Shared	7.32675	7.6375	4	4	3
42	7x42	Shared	6.396	5.98429	5	7	6
43	7x49	Shared	5.12075	10.9025	4	4	9
44	7x53	Shared	5.2126	5.65286	5	7	9
45	8x50	Shared	6.14283	7.755	6	4	8
46	Lig	Shared	9.71727	11.2592	11	12	0
47	1x35	a2a_on	11.3493	14.445	3	6	5
48	2x46	a2a_on	4.0215	6.292	2	5	9
49	2x63	a2a_on	3.599	2.925	1	4	4
50	3x26	a2a_on	4.511	2.984	3	5	6
51	3x35	a2a_on	5.84633	4.1525	3	4	7
52	3x38	a2a_on	11.547	3.635	2	4	6
53	3x43	a2a_on	4.3975	5.218	2	5	8
54	5x42	a2a_on	6.193	4.8375	3	4	4
55	5x43	a2a_on	5.721	9.0825	3	4	5
56	5x58	a2a_on	5.81	5.54714	3	7	9
57	5x62	a2a_on	2.897	3.8425	3	4	5
58	7x38	a2a_on	8.4785	7.865	2	4	4
59	7x41	a2a_on	7.7795	4.0675	2	4	7
60	7x45	a2a_on	6.85733	9.005	3	4	9
61	7x50	a2a_on	5.841	4.7025	3	4	9
62	7x52	a2a_on	3.94333	3.51	3	4	8
63	8x53	a2a_on	5.085	5.636	3	5	7

Orange: nodes, hubs and links specific of a2a_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of a2a_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	a2a_off Recurrence	a2a_on Recurrence	a2a_off Hub1?	a2a_on Hub1?	a2a_off Hub2?	a2a_on Hub2?	ConSurf1	ConSurf2
1	3x39	6x44	a2a_off	100	0	No	No	Yes	Yes	9	9
2	2x46	3x39	a2a_off	39.784	0	No	Yes	No	No	9	9
3	2x46	7x49	a2a_off	39.6723	7.73437	No	Yes	Yes	Yes	9	9
4	7x49	7x53	a2a_off	77.625	0	Yes	Yes	Yes	Yes	9	9
5	7x53	8x50	a2a_off	53.2109	0	Yes	Yes	Yes	Yes	9	8
6	8x50	8x54	a2a_off	13.2324	0	Yes	Yes	Yes	No	8	6
7	2x43	7x53	a2a_off	27.8994	0	No	No	Yes	Yes	8	9
8	2x40	2x43	a2a_off	27.1407	0	Yes	Yes	No	No	8	8
9	2x37	2x40	a2a_off	54.2796	4.08594	No	No	Yes	Yes	7	8
10	2x37	2x39	a2a_off	52.5542	2.04688	No	No	No	No	7	8
11	2x39	3x49	a2a_off	40.8777	0	No	No	Yes	No	8	9
12	3x49	I2x57	a2a_off	34.0554	0	Yes	No	Yes	No	9	7
13	2x38	I2x57	a2a_off	21.8031	0	No	No	Yes	No	6	7
14	2x38	4x39	a2a_off	18.2139	0	No	No	No	No	6	1
15	2x41	4x39	a2a_off	10.9738	0	No	No	No	No	5	1
16	3x40	6x44	a2a_off	45.1351	5.46094	No	No	Yes	Yes	7	9
17	3x37	3x40	a2a_off	42.5471	0	Yes	Yes	No	No	5	7
18	3x38	4x50	a2a_off	35.7923	2.40625	No	Yes	No	No	6	9
19	2x45	4x50	a2a_off	34.2095	0	No	No	No	No	9	9
20	2x45	4x46	a2a_off	32.6112	5.19531	No	No	No	No	9	8
21	2x42	4x46	a2a_off	31.8064	0	Yes	Yes	No	No	7	8
22	2x42	3x46	a2a_off	29.3397	0	Yes	Yes	No	No	7	8
23	2x53	3x35	a2a_off	28.1882	0	No	No	No	Yes	6	7
24	3x31	3x35	a2a_off	27.1638	0	Yes	No	No	Yes	5	7
25	3x27	3x31	a2a_off	25.221	0	No	No	Yes	No	4	5
26	3x27	4x61	a2a_off	22.839	9.34375	No	No	No	No	4	5
27	2x65	2x66	a2a_off	10.1381	9.34375	No	No	No	No	5	4
28	6x52	Lig	a2a_off	17.5168	6.28125	Yes	Yes	Yes	Yes	6	0
29	3x46	6x37	a2a_off	28.5194	0	No	No	No	No	8	8
30	5x57	5x61	a2a_off	24.4604	0	No	No	No	No	7	9
31	3x54	5x61	a2a_off	20.1798	0	No	No	No	No	8	9
32	5x47	6x52	a2a_off	10.8005	2.25781	No	No	Yes	Yes	7	6
33	6x40	7x49	a2a_off	13.3249	0	No	No	Yes	Yes	8	9
34	6x40	7x52	a2a_off	15.6143	0	No	No	No	Yes	8	8
35	6x39	7x56	a2a_off	10.683	6.71875	No	No	Yes	No	6	7
36	3x54	5x68	a2a_off	14.2568	0	No	No	Yes	No	8	6
37	5x68	6x27	a2a_off	11.8865	0	Yes	No	No	No	6	4
38	5x69	6x27	a2a_off	10.2035	0	No	No	No	No	5	4
39	5x47	5x51	a2a_off	10.0495	0	No	No	No	No	7	6
40	1x39	7x42	Shared	10.0476	10.2422	Yes	Yes	Yes	Yes	6	6
41	6x48	Lig	Shared	47.3379	100	Yes	Yes	Yes	Yes	8	0
42	6x44	6x48	Shared	68.6288	63.3438	Yes	Yes	Yes	Yes	9	8
43	2x50	3x39	Shared	60.6897	28.8437	Yes	Yes	No	No	9	9
44	2x50	7x49	Shared	52.1326	27.6484	Yes	Yes	Yes	Yes	9	9
45	8x50	I1x50	Shared	10.7658	19.3672	Yes	Yes	Yes	Yes	8	8
46	2x40	8x50	Shared	28.0997	11.3672	Yes	Yes	Yes	Yes	8	8
47	3x37	4x53	Shared	36.9264	32.375	Yes	Yes	No	No	5	7
48	3x38	4x53	Shared	36.5779	31.8125	No	Yes	No	No	6	7
49	2x50	7x46	Shared	30.6818	16.9141	Yes	Yes	No	No	9	9
50	2x53	7x46	Shared	29.696	16.9844	No	No	No	No	6	9
51	3x26	4x61	Shared	22.5155	24.6172	No	Yes	No	No	6	5
52	3x26	E2.V171	Shared	14.7787	27.625	No	Yes	No	No	6	4
53	3x25	E2.V171	Shared	14.2742	24.6172	No	No	No	No	9	4
54	3x25	E2x50	Shared	13.6657	21.5938	No	No	No	No	9	9
55	E1x50	E2x50	Shared	12.5412	18.5547	Yes	No	No	No	7	9
56	2x65	E1x50	Shared	10.7716	12.4297	No	No	Yes	No	5	7
57	5x40	Lig	Shared	10.0687	74.0625	Yes	Yes	Yes	Yes	6	0
58	5x58	6x37	Shared	27.6683	39.6797	No	Yes	No	No	9	8
59	3x47	5x58	Shared	26.1356	12.5313	No	No	No	Yes	9	9
60	3x47	5x57	Shared	25.2999	10.0547	No	No	No	No	9	7
61	6x39	7x52	Shared	11.6785	12.7031	No	No	No	Yes	6	8
62	7x41	7x42	Shared	20.4976	15.9219	No	Yes	Yes	Yes	7	6
63	6x48	7x41	Shared	21.2909	18.3203	Yes	Yes	No	Yes	8	7
64	2x57	7x42	Shared	12.8338	21.7266	Yes	Yes	Yes	Yes	6	6
65	1x35	7x35	a2a_on	2.51285	16.5234	No	Yes	Yes	Yes	5	3
66	1x35	7x38	a2a_on	0	20.8984	No	Yes	No	Yes	5	4
67	1x35	7x39	a2a_on	0	34.375	No	Yes	No	No	5	5
68	1x35	7x42	a2a_on	0	36.1016	No	Yes	Yes	Yes	5	6
69	1x39	2x61	a2a_on	9.98402	12.3906	Yes	Yes	No	No	6	6
70	1x38	7x39	a2a_on	0	12.3672	No	No	No	No	5	5
71	1x42	7x39	a2a_on	0	18.4688	Yes	No	No	No	7	5
72	2x53	2x57	a2a_on	0	19.4297	No	No	Yes	Yes	6	6
73	2x53	2x56	a2a_on	1.38448	16.7344	No	No	No	No	6	6
74	2x56	3x35	a2a_on	0	15.4453	No	No	No	Yes	6	7
75	2x551	3x35	a2a_on	0	21.375	No	No	No	Yes	5	7
76	2x55	2x551	a2a_on	0	12.3047	No	No	No	No	5	5
77	2x50	7x50	a2a_on	0	43.5547	Yes	Yes	No	Yes	9	9
78	1x53	7x50	a2a_on	2.12004	39.3594	No	No	No	Yes	9	9
79	1x53	8x50	a2a_on	0	34.0781	No	No	Yes	Yes	9	8
80	7x38	Lig	a2a_on	4.60593	27.8281	No	Yes	Yes	Yes	4	0
81	5x40	5x43	a2a_on	0	32.0703	Yes	Yes	No	Yes	6	5
82	5x43	5x461	a2a_on	0	37.6719	No	Yes	Yes	No	5	5
83	3x37	5x461	a2a_on	6.96474	35.8125	Yes	Yes	Yes	No	5	5
84	3x37	3x41	a2a_on	4.28244	57.0312	Yes	Yes	Yes	No	5	5
85	3x41	4x49	a2a_on	0.9493	63.3828	Yes	No	No	No	5	7
86	3x45	4x49	a2a_on	0	60.6406	No	No	No	No	7	7
87	3x45	4x45	a2a_on	0	57.8828	No	No	No	No	7	5
88	2x42	4x45	a2a_on	0.920417	55.0859	Yes	Yes	No	No	7	5
89	7x42	Lig	a2a_on	0	39.0547	Yes	Yes	Yes	Yes	6	0
90	2x42	3x49	a2a_on	0	35.2188	Yes	Yes	Yes	No	7	9
91	6x48	7x45	a2a_on	0.799107	46.7031	Yes	Yes	No	Yes	8	9
92	7x45	7x49	a2a_on	0	29.3047	No	Yes	Yes	Yes	9	9
93	2x46	3x42	a2a_on	0	10.3359	No	Yes	No	No	9	7
94	2x46	2x50	a2a_on	0	32.3125	No	Yes	Yes	Yes	9	9
95	3x43	6x44	a2a_on	7.23817	23.625	No	Yes	Yes	Yes	8	9
96	3x43	7x53	a2a_on	0	32.5391	No	Yes	Yes	Yes	8	9
97	3x43	7x45	a2a_on	0	16.75	No	Yes	No	Yes	8	9
98	E2x52	Lig	a2a_on	4.46152	11.6016	Yes	Yes	Yes	Yes	4	0
99	5x39	5x40	a2a_on	5.27988	48.9766	Yes	Yes	Yes	Yes	6	6
100	4x60	5x39	a2a_on	1.03017	59.5078	No	No	Yes	Yes	5	6
101	3x30	4x60	a2a_on	0.130938	67.75	No	No	No	No	5	5
102	3x26	3x30	a2a_on	0	64.9531	No	Yes	No	No	6	5
103	4x58	4x61	a2a_on	0.223365	12.4297	No	No	No	No	3	5
104	3x35	3x38	a2a_on	0	16.7812	No	Yes	No	Yes	7	6
105	5x39	5x42	a2a_on	3.8954	19.5156	Yes	Yes	No	Yes	6	4
106	4x56	5x42	a2a_on	0	28.4844	No	No	No	Yes	4	4
107	3x40	6x48	a2a_on	0	12.7891	No	No	Yes	Yes	7	8
108	3x40	5x50	a2a_on	2.73044	15.6953	No	No	No	No	7	8
109	4x52	4x56	a2a_on	0	11.7109	No	No	No	No	4	4
110	5x54	6x44	a2a_on	0	44.6484	No	No	Yes	Yes	8	9
111	5x49	5x50	a2a_on	1.8235	13.1172	No	No	No	No	5	8
112	5x54	5x58	a2a_on	0	44.4844	No	No	No	Yes	8	9
113	3x49	I2x53	a2a_on	5.36653	32.3281	Yes	No	Yes	Yes	9	7
114	I2x53	I2x57	a2a_on	0.213737	18.1797	Yes	Yes	Yes	No	7	7
115	I2x56	I2x57	a2a_on	1.83698	15.1875	No	No	Yes	No	4	7
116	3x52	I2x56	a2a_on	0	12.1797	No	No	No	No	5	4
117	2x42	4x42	a2a_on	0	15.1875	Yes	Yes	No	No	7	7
118	4x39	4x42	a2a_on	0	12.1797	No	No	No	No	1	7
119	4x59	4x60	a2a_on	0.00577667	13.9453	No	No	No	No	6	5
120	4x59	5x42	a2a_on	0	14.2344	No	No	No	Yes	6	4
121	6x55	Lig	a2a_on	5.90183	16.3125	No	No	Yes	Yes	5	0
122	5x37	6x55	a2a_on	5.15472	20.9297	No	No	No	No	4	5
123	5x37	6x58	a2a_on	0	10.3281	No	No	No	No	4	4
124	5x51	6x44	a2a_on	0	12.0156	No	No	Yes	Yes	6	9
125	5x58	6x41	a2a_on	0	14.9219	No	Yes	No	No	9	8
126	5x62	6x37	a2a_on	0	35.3516	No	Yes	No	No	5	8
127	5x62	6x30	a2a_on	0	26.5078	No	Yes	No	No	5	7
128	6x27	6x30	a2a_on	0	19.6016	No	No	No	No	4	7
129	6x27	6x31	a2a_on	0	17.1719	No	No	No	No	4	5
130	6x28	6x31	a2a_on	0	14.7266	No	No	No	No	4	5
131	6x28	6x29	a2a_on	0	12.2656	No	No	No	No	4	6
132	7x52	7x53	a2a_on	0	32.3359	No	Yes	Yes	Yes	8	9
133	7x34	Lig	a2a_on	6.31968	12.1484	No	No	Yes	Yes	4	0
134	7x34	E3.A265	a2a_on	0	10.3828	No	No	No	No	4	4
135	7x51	7x52	a2a_on	0	10.0938	No	No	No	Yes	6	8
136	2x49	3x38	a2a_on	0	28.2266	No	No	No	Yes	8	6
137	2x49	3x39	a2a_on	0	28.2188	No	No	No	No	8	9
138	2x46	7x53	a2a_on	0	29.7812	No	Yes	Yes	Yes	9	9
139	5x58	7x53	a2a_on	0	23.4531	No	Yes	Yes	Yes	9	9
140	3x37	4x56	a2a_on	1.6271	17.4141	Yes	Yes	No	No	5	4
141	3x41	4x52	a2a_on	2.8402	10.1953	Yes	No	No	No	5	4

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
1x35	1x39	Shared	14.927	38.16	1	1	2	2
1x35	2x64	Shared	4.326	3.82	1	1	2	2
1x35	7x35	Shared	14.795	13.9	1	1	2	1
1x39	2x57	a2a_off	7.515	0	1	1	2	2
1x39	7x42	Shared	12.433	6.15	1	1	2	1
2x57	7x42	Shared	9.147	7.95	1	0	2	1
3x33	5x39	Shared	3.635	3.52	1	1	2	2
3x33	5x40	a2a_off	3.958	0	1	1	2	1
3x33	5x43	Shared	6.73	10.98	1	1	2	2
3x36	6x48	a2a_off	8.946	0	0	0	1	1
3x40	6x44	Shared	6.028	5.02	0	1	2	2
E2.V172	E2x52	Shared	11.799	9.18	1	1	2	1
5x40	E2x52	Shared	5.597	4.98	1	1	1	1
E2x52	Lig	Shared	31.103	54.67	1	1	1	0
5x37	E2.E169	a2a_off	5.414	0	0	0	2	1
E2.E169	E3.H264	a2a_off	9.234	0	1	1	1	1
E2.E169	Lig	Shared	6.549	9.15	1	1	1	0
5x40	E2.V172	Shared	3.192	3.04	1	1	1	2
5x37	6x55	Shared	7.149	4.21	0	0	2	1
5x39	5x40	Shared	3.83	3.59	1	1	2	1
5x39	5x43	Shared	6.86	10.47	1	1	2	2
5x40	Lig	Shared	5.101	3.91	1	1	1	0
5x43	6x52	a2a_off	3.573	0	1	1	2	1
5x44	5x47	Shared	3.406	5.24	1	1	2	2
5x44	6x52	Shared	24.89	13.58	1	1	2	1
5x47	6x52	Shared	6.505	6.92	1	1	2	1
6x44	6x48	Shared	13.33	7.02	1	1	2	1
6x44	7x45	a2a_off	8.338	0	1	1	2	2
6x48	7x41	Shared	11.936	4.94	1	1	1	1
6x48	7x45	Shared	3.729	13.56	1	1	1	2
6x48	Lig	Shared	5.333	8.65	1	1	1	0
6x51	Lig	Shared	15.555	11.47	0	1	1	0
6x52	Lig	Shared	5.87	4.44	1	1	1	0
6x54	7x34	a2a_off	3.355	0	0	0	2	1
6x55	Lig	Shared	10.507	5.69	0	1	1	0
6x58	E3.H264	Shared	9.994	2.74	0	0	2	1
7x34	E3.H264	a2a_off	3.808	0	1	0	1	1
7x31	7x35	Shared	6.799	9.38	0	0	2	1
7x34	Lig	Shared	4.67	3.91	1	0	1	0
7x35	Lig	a2a_off	4.406	0	1	0	1	0
7x38	7x42	Shared	3.847	3.98	0	1	1	1
7x38	Lig	Shared	13.11	8.87	0	1	1	0
7x41	7x42	Shared	3.623	4.18	0	1	1	1
2x64	7x35	a2a_off	3.307	0	1	0	2	1
E3.H264	Lig	a2a_off	4.686	0	1	0	1	0
6x51	7x37	Shared	3.151	3.15	0	1	1	2
2x60	7x42	Shared	2.93	2.93	0	0	2	1
3x29	E2x52	a2a_off	2.493	0	0	0	2	1
6x54	E3.A265	Shared	2.433	1.62	0	0	2	2
1x33	7x35	a2a_on	0	5.34	0	0	2	1
1x35	7x38	a2a_on	0	14.51	1	1	2	1
1x35	7x42	a2a_on	0	8.71	1	1	2	1
1x39	7x38	a2a_on	0	4.1	1	1	2	1
2x63	3x29	a2a_on	0	3.25	0	1	2	2
3x36	Lig	a2a_on	0	12.21	0	0	1	0
3x40	6x48	a2a_on	0	17.62	0	1	2	1
E2.E169	E2x52	a2a_on	0	5.83	1	1	1	1
5x37	6x58	a2a_on	0	3.01	0	0	2	2
5x40	5x43	a2a_on	0	7.01	1	1	1	2
5x40	6x52	a2a_on	0	3.94	1	1	1	1
5x40	6x55	a2a_on	0	4.21	1	1	1	1
6x51	7x41	a2a_on	0	3	0	1	1	1
7x34	E3.A265	a2a_on	0	3.22	1	0	1	2
7x41	Lig	a2a_on	0	4.15	0	1	1	0
7x42	Lig	a2a_on	0	7.99	1	1	1	0
2x63	E2x52	a2a_on	0	2.51	0	1	2	1
7x32	7x35	a2a_on	0	1.93	7	0	2	1
6x54	7x37	a2a_on	0	1.62	0	0	2	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	a2a_off	8C9W-A_2A-Etrumadenant 3UZA-A_2A-GTPL9236 8GNG-A_2A-Istradefylline 5UIG-A_2A-J3.651.884G 8CU6-A_2A-LJ-4517 7PX4-A_2A-PSB-2113 7PYR-A_2A-PSB-2115 8DU3-A_2A-PubChem 105526064 8JWY-A_2A-PubChem 168451710 5K2D-A_2A-ZM241385
	a2a_on	6GDG-A_2A-NECA-Gs/&β;1/&γ;1

Network Difference
Value	a2a_off	a2a_on
I_min	3.152	2.95
Number of Linked Nodes	307	241
Number of Specific Nodes	67 (21.82%)	1 (0.41%)
Number of Shared Nodes	240 (78.18%)	240 (99.59%)
Number of Links	349	275
Number of Specific Links	188 (53.87%)	114 (41.45%)
Number of Shared Links	161 (46.13%)	161 (58.55%)
Number of Hubs	46	39
Number of Specific Hubs	24 (52.17%)	17 (43.59%)
Number of Shared Hubs	22 (47.83%)	22 (56.41%)
Average % Shared Neighbours (Jaccard)	36.20
Average % Shared Neighbours (Otsuka)	44.32
Average % Shared Neighbours (Overlap Coefficient)	52.37
Average % Shared Cliques (k3-6)	52.73
Graphlets Similarity	0.62202

Paths Difference
Value	a2a_off	a2a_on
Number Of Nodes in MetaPath	63	92
Specific Nodes in MetaPath	21 (33.33%)	50 (54.35%)
Shared Nodes in MetaPath	240 (78.18%)	240 (78.18%)
Number Of Links MetaPath	64	102
Specific Links in MetaPath	39 (60.94%)	77 (75.49%)
Shared Links in MetaPath	161 (46.13%)	161 (46.13%)
Number of Shortest Paths	81881	41107
Length Of Smallest Path	3	3
Average Path Length	16.999	11.6931
Length of Longest Path	50	31
Minimum Path Strength	0.386	1.365
Average Path Strength	5.8926	6.19394
Maximum Path Strength	20.621	31.925
Minimum Path Correlation	0.703	0.7
Average Path Correlation	0.917515	0.919409
Maximum Path Correlation	0.99	0.99
Minimum % Of Corr. Nodes	2.27273	4
Average % Of Corr. Nodes	39.2425	50.3753
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	42.3514	48.4083
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

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