psnGPCR

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Orange: nodes, hubs and links specific of a2a_off_allo network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of a2a_off network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	a2a_off_allo Int. Strength	a2a_off Int. Strength	a2a_off_allo Hub1?	a2a_off Hub1?	a2a_off_allo Hub2?	a2a_off Hub2?	ConSurf1	ConSurf2
1	1x38	7x39	a2a_off_allo	100	0	No	No	No	No	5	5
2	1x42	7x39	a2a_off_allo	100	0	No	Yes	No	No	7	5
3	1x53	2x47	a2a_off_allo	100	0	No	No	No	No	9	9
4	2x46	3x42	a2a_off_allo	100	0	No	No	No	No	9	7
5	2x50	Na	a2a_off_allo	100	0	No	Yes	No	No	9	0
6	2x551	2x59	a2a_off_allo	100	0	No	No	No	No	5	5
7	2x63	3x28	a2a_off_allo	100	0	No	No	No	No	4	6
8	3x39	Na	a2a_off_allo	100	0	No	No	No	No	9	0
9	3x40	5x47	a2a_off_allo	100	0	Yes	No	No	No	7	7
10	3x52	I2x53	a2a_off_allo	100	0	Yes	No	Yes	Yes	5	7
11	4x59	5x42	a2a_off_allo	100	0	Yes	No	Yes	No	6	4
12	E2.K153	E2x51	a2a_off_allo	100	0	Yes	No	Yes	No	4	4
13	5x40	5x43	a2a_off_allo	100	0	Yes	Yes	Yes	No	6	5
14	5x40	6x55	a2a_off_allo	100	0	Yes	Yes	No	No	6	5
15	7x53	8x47	a2a_off_allo	100	0	Yes	Yes	No	No	9	8
16	2x55	2x551	a2a_off_allo	38.4615	0	No	No	No	No	5	5
17	3x48	3x52	a2a_off_allo	7.69231	0	No	No	Yes	No	6	5
18	5x51	5x54	a2a_off_allo	7.69231	0	No	No	No	No	6	8
19	6x39	6x43	a2a_off_allo	0	0	No	No	Yes	No	6	7
20	1x40	2x61	a2a_off_allo	0	0	No	No	No	No	5	6
21	5x58	5x62	a2a_off_allo	23.0769	0	Yes	No	No	No	9	5
22	5x44	6x49	a2a_off_allo	0	0	Yes	Yes	No	No	5	6
23	E2.N145	E2.Q148	a2a_off_allo	46.1538	0	No	No	No	No	4	3
24	7x30	E3.A265	a2a_off_allo	0	0	No	No	No	No	3	4
25	3x54	6x27	a2a_off_allo	0	0	Yes	No	Yes	No	8	4
26	1x46	7x47	a2a_off_allo	0	0	No	No	No	No	7	7
27	3x54	5x64	a2a_off_allo	7.69231	0	Yes	No	No	No	8	6
28	1x52	8x58	a2a_off_allo	0	0	No	No	No	No	6	6
29	E2.172	E2x52	a2a_off_allo	7.69231	0	No	No	Yes	Yes	0	4
30	6x41	6x42	a2a_off_allo	0	0	No	No	No	No	8	5
31	E2.169	E3.H264	a2a_off_allo	7.69231	0	No	No	Yes	Yes	0	2
32	E2.170	E2x51	a2a_off_allo	7.69231	0	No	No	Yes	No	0	4
33	8x56	8x61	a2a_off_allo	7.69231	0	No	No	No	No	4	0
34	6x21	6x22	a2a_off_allo	7.69231	0	No	No	No	No	4	1
35	3x25	E2.171	a2a_off_allo	7.69231	0	No	No	No	No	9	0
36	I2x52	I2x55	a2a_off_allo	7.69231	0	No	No	No	No	5	5
37	E2.P149	E2.Q154	a2a_off_allo	7.69231	0	No	No	No	No	5	0
38	1x29	1x32	a2a_off_allo	0	0	No	No	No	No	5	4
39	E2.E161	E2.H155	a2a_off_allo	0	0	No	No	No	No	3	3
40	E2.G152	E2.H155	a2a_off_allo	0	0	No	No	No	No	2	3
41	5x52	5x55	a2a_off_allo	0	0	No	No	No	No	3	4
42	2x48	4x50	a2a_off_allo	0	0	No	No	Yes	No	7	9
43	5x63	5x67	a2a_off_allo	0	0	No	No	No	No	4	4
44	8x63	8x64	a2a_off_allo	0	0	No	No	No	No	0	0
45	1x27	1x30	Shared	100	10	No	No	No	Yes	6	4
46	1x35	1x39	Shared	100	100	No	No	Yes	Yes	5	6
47	1x35	2x64	Shared	100	100	No	No	No	No	5	3
48	1x35	7x35	Shared	100	100	No	No	No	Yes	5	3
49	1x36	2x61	Shared	100	100	No	No	No	No	6	6
50	1x39	2x57	Shared	100	100	Yes	Yes	Yes	Yes	6	6
51	1x39	2x61	Shared	100	100	Yes	Yes	No	No	6	6
52	1x39	7x39	Shared	100	100	Yes	Yes	No	No	6	5
53	1x39	7x42	Shared	100	100	Yes	Yes	Yes	Yes	6	6
54	1x43	2x57	Shared	100	100	No	No	Yes	Yes	6	6
55	1x45	7x47	Shared	100	100	No	No	No	No	5	7
56	1x47	2x54	Shared	100	100	No	No	No	No	6	7
57	1x49	7x50	Shared	100	100	No	No	No	No	9	9
58	1x50	2x47	Shared	100	100	Yes	Yes	No	No	9	9
59	1x50	2x50	Shared	100	100	Yes	Yes	No	Yes	9	9
60	1x50	7x50	Shared	100	100	Yes	Yes	No	No	9	9
61	1x52	8x54	Shared	100	100	No	No	No	Yes	6	6
62	1x52	8x57	Shared	100	100	No	No	No	No	6	6
63	1x53	7x50	Shared	100	100	No	No	No	No	9	9
64	1x53	7x53	Shared	100	100	No	No	Yes	Yes	9	9
65	1x55	1x59	Shared	100	100	No	No	No	No	4	5
66	1x55	8x57	Shared	100	100	No	No	No	No	4	6
67	1x56	8x53	Shared	100	100	No	No	No	No	8	7
68	1x57	2x44	Shared	100	100	No	No	No	No	7	5
69	1x60	I1x49	Shared	100	100	Yes	Yes	No	No	6	5
70	1x60	I1x50	Shared	100	100	Yes	Yes	Yes	Yes	6	8
71	1x60	8x49	Shared	100	100	Yes	Yes	Yes	Yes	6	6
72	1x60	8x53	Shared	100	100	Yes	Yes	No	No	6	7
73	8x49	I1x49	Shared	100	100	Yes	Yes	No	No	6	5
74	2x40	I1x50	Shared	100	100	Yes	Yes	Yes	Yes	8	8
75	8x49	I1x50	Shared	100	100	Yes	Yes	Yes	Yes	6	8
76	8x50	I1x50	Shared	100	100	Yes	Yes	Yes	Yes	8	8
77	8x53	I1x50	Shared	100	100	No	No	Yes	Yes	7	8
78	2x37	2x39	Shared	100	100	No	No	No	No	7	8
79	2x37	2x40	Shared	100	100	No	No	Yes	Yes	7	8
80	2x38	I2x57	Shared	100	100	No	No	Yes	Yes	6	7
81	2x38	4x42	Shared	100	100	No	No	No	No	6	7
82	2x39	3x49	Shared	100	100	No	No	Yes	Yes	8	9
83	2x39	3x50	Shared	100	100	No	No	Yes	Yes	8	9
84	2x40	2x43	Shared	100	100	Yes	Yes	No	No	8	8
85	2x40	8x50	Shared	100	100	Yes	Yes	Yes	Yes	8	8
86	2x42	3x45	Shared	100	100	Yes	Yes	No	No	7	7
87	2x42	3x46	Shared	100	100	Yes	Yes	No	No	7	8
88	2x42	4x45	Shared	100	100	Yes	Yes	No	No	7	5
89	2x42	4x46	Shared	100	100	Yes	Yes	No	No	7	8
90	2x43	7x53	Shared	100	100	No	No	Yes	Yes	8	9
91	2x45	3x42	Shared	100	100	No	No	No	No	9	7
92	2x45	4x46	Shared	100	100	No	No	No	No	9	8
93	2x45	4x50	Shared	100	100	No	No	Yes	No	9	9
94	2x46	7x49	Shared	100	100	No	No	No	Yes	9	9
95	2x50	7x46	Shared	100	100	No	Yes	No	No	9	9
96	2x52	3x35	Shared	100	100	No	No	No	No	6	7
97	2x53	2x56	Shared	100	100	No	No	No	No	6	6
98	2x53	3x35	Shared	100	100	No	No	No	No	6	7
99	2x53	7x46	Shared	100	100	No	No	No	No	6	9
100	2x551	3x31	Shared	100	100	No	No	Yes	Yes	5	5
101	2x56	3x32	Shared	100	100	No	No	No	No	6	6
102	2x57	2x58	Shared	100	100	Yes	Yes	No	No	6	8
103	2x57	7x42	Shared	100	100	Yes	Yes	Yes	Yes	6	6
104	2x59	3x28	Shared	100	100	No	No	No	No	5	6
105	2x59	3x31	Shared	100	100	No	No	Yes	Yes	5	5
106	2x62	E1x50	Shared	100	100	No	No	Yes	Yes	5	7
107	2x65	E1x50	Shared	100	70	No	No	Yes	Yes	5	7
108	E1x50	E1x52	Shared	100	100	Yes	Yes	No	No	7	6
109	E1x50	E2x50	Shared	100	100	Yes	Yes	No	No	7	9
110	E1x51	E2.C159	Shared	100	100	No	No	No	No	2	3
111	E1x51	E2.Q163	Shared	100	100	No	No	No	No	2	3
112	3x22	E2.C146	Shared	100	100	No	No	No	No	3	1
113	3x22	E2.V164	Shared	100	100	No	No	No	No	3	4
114	3x23	E2.C146	Shared	100	100	No	No	No	No	2	1
115	3x25	E2x50	Shared	100	100	No	No	No	No	9	9
116	3x25	E2.V171	Shared	100	100	No	No	No	No	9	4
117	3x26	E2.N144	Shared	100	100	No	No	No	No	6	4
118	3x27	3x31	Shared	100	100	No	No	Yes	Yes	4	5
119	3x27	4x58	Shared	100	100	No	No	No	No	4	3
120	3x27	4x61	Shared	100	100	No	No	No	No	4	5
121	3x30	4x60	Shared	100	100	No	No	No	No	5	5
122	3x31	3x35	Shared	100	100	Yes	Yes	No	No	5	7
123	3x33	5x39	Shared	100	100	No	Yes	Yes	Yes	4	6
124	3x33	5x40	Shared	100	100	No	Yes	Yes	Yes	4	6
125	3x33	5x43	Shared	100	100	No	Yes	Yes	No	4	5
126	3x34	4x54	Shared	100	100	No	No	No	No	4	3
127	3x34	4x58	Shared	100	100	No	No	No	No	4	3
128	3x36	6x48	Shared	100	100	No	No	Yes	Yes	6	8
129	3x37	3x40	Shared	100	100	Yes	Yes	Yes	No	5	7
130	3x37	3x41	Shared	100	100	Yes	Yes	Yes	Yes	5	5
131	3x37	4x53	Shared	100	100	Yes	Yes	No	No	5	7
132	3x37	4x56	Shared	100	100	Yes	Yes	No	No	5	4
133	3x37	5x461	Shared	100	100	Yes	Yes	Yes	Yes	5	5
134	3x38	4x50	Shared	100	100	No	No	Yes	No	6	9
135	3x38	4x53	Shared	100	100	No	No	No	No	6	7
136	3x39	6x44	Shared	100	100	No	No	Yes	Yes	9	9
137	3x40	5x50	Shared	100	100	Yes	No	No	No	7	8
138	3x40	6x44	Shared	100	100	Yes	No	Yes	Yes	7	9
139	3x41	4x49	Shared	100	100	Yes	Yes	No	No	5	7
140	3x41	4x53	Shared	100	100	Yes	Yes	No	No	5	7
141	3x43	6x44	Shared	100	100	No	No	Yes	Yes	8	9
142	3x44	3x48	Shared	100	100	No	No	No	No	7	6
143	3x44	5x54	Shared	100	100	No	No	No	No	7	8
144	3x47	5x57	Shared	100	60	No	No	No	No	9	7
145	3x47	5x58	Shared	100	100	No	No	Yes	No	9	9
146	3x49	3x50	Shared	100	100	Yes	Yes	Yes	Yes	9	9
147	3x49	I2x53	Shared	100	100	Yes	Yes	Yes	Yes	9	7
148	3x49	I2x57	Shared	100	100	Yes	Yes	Yes	Yes	9	7
149	3x50	3x53	Shared	100	100	Yes	Yes	No	No	9	8
150	3x51	3x55	Shared	100	100	No	No	No	No	8	6
151	3x51	5x60	Shared	100	100	No	No	No	No	8	5
152	3x51	5x61	Shared	100	100	No	No	No	No	8	9
153	3x52	I2x57	Shared	100	100	Yes	No	Yes	Yes	5	7
154	3x53	I2x53	Shared	100	100	No	No	Yes	Yes	8	7
155	3x54	5x61	Shared	100	30	Yes	No	No	No	8	9
156	3x54	6x30	Shared	100	100	Yes	No	No	No	8	7
157	I2x53	I2x54	Shared	100	100	Yes	Yes	No	No	7	5
158	I2x53	I2x57	Shared	100	100	Yes	Yes	Yes	Yes	7	7
159	I2x56	I2x57	Shared	100	40	No	No	Yes	Yes	4	7
160	4x38	4x41	Shared	100	100	No	No	No	No	7	5
161	4x56	4x57	Shared	100	70	No	No	No	No	4	6
162	4x56	5x461	Shared	100	100	No	No	Yes	Yes	4	5
163	4x58	4x61	Shared	100	100	No	No	No	No	3	5
164	4x59	4x60	Shared	100	100	Yes	No	No	No	6	5
165	4x59	5x39	Shared	100	100	Yes	No	Yes	Yes	6	6
166	4x60	5x39	Shared	100	100	No	No	Yes	Yes	5	6
167	5x36	E2.W143	Shared	100	100	No	Yes	Yes	Yes	4	5
168	5x38	E2.W143	Shared	100	100	No	No	Yes	Yes	4	5
169	5x39	E2.W143	Shared	100	100	Yes	Yes	Yes	Yes	6	5
170	5x42	E2.W143	Shared	100	100	Yes	No	Yes	Yes	4	5
171	E2.C146	E2.N144	Shared	100	100	No	No	No	No	1	4
172	5x36	E2.N145	Shared	100	100	No	Yes	No	No	4	4
173	E2.E151	E2.P149	Shared	100	100	No	No	No	No	2	5
174	E2.K150	E2.K153	Shared	100	100	No	No	Yes	No	3	4
175	E2.D170	E2.K150	Shared	100	100	No	No	No	No	4	3
176	E2.E151	E2.H155	Shared	100	40	No	No	No	No	2	3
177	E2.D170	E2.K153	Shared	100	100	No	No	Yes	No	4	4
178	E2.A165	E2.Q157	Shared	100	30	No	No	Yes	Yes	3	3
179	E2.G160	E2.Q163	Shared	100	100	No	No	No	No	1	3
180	E2.D170	E2x51	Shared	100	100	No	No	Yes	No	4	4
181	E2.V172	E2x52	Shared	100	100	No	No	Yes	Yes	3	4
182	5x40	E2x52	Shared	100	100	Yes	Yes	Yes	Yes	6	4
183	E2x52	Lig	Shared	100	100	Yes	Yes	Yes	Yes	4	0
184	5x37	E2.E169	Shared	100	100	No	No	No	No	4	3
185	E2.E169	E3.H264	Shared	100	100	No	No	Yes	Yes	3	2
186	E2.E169	Lig	Shared	100	100	No	No	Yes	Yes	3	0
187	5x36	5x38	Shared	100	100	No	Yes	No	No	4	4
188	5x37	6x55	Shared	100	100	No	No	No	No	4	5
189	5x37	6x59	Shared	100	100	No	No	Yes	Yes	4	3
190	5x39	5x40	Shared	100	100	Yes	Yes	Yes	Yes	6	6
191	5x39	5x42	Shared	100	100	Yes	Yes	Yes	No	6	4
192	5x39	5x43	Shared	100	100	Yes	Yes	Yes	No	6	5
193	5x40	Lig	Shared	100	100	Yes	Yes	Yes	Yes	6	0
194	5x41	5x45	Shared	100	100	No	No	Yes	Yes	5	4
195	5x41	6x59	Shared	100	100	No	No	Yes	Yes	5	3
196	5x411	5x45	Shared	100	100	No	No	Yes	Yes	5	4
197	5x411	6x59	Shared	100	100	No	No	Yes	Yes	5	3
198	5x411	6x60	Shared	100	100	No	No	Yes	Yes	5	6
199	5x42	5x461	Shared	100	100	Yes	No	Yes	Yes	4	5
200	5x43	6x52	Shared	100	100	Yes	No	Yes	Yes	5	6
201	5x44	5x45	Shared	100	100	Yes	Yes	Yes	Yes	5	4
202	5x44	5x47	Shared	100	100	Yes	Yes	No	No	5	7
203	5x44	5x48	Shared	100	100	Yes	Yes	No	No	5	4
204	5x44	6x52	Shared	100	100	Yes	Yes	Yes	Yes	5	6
205	5x45	6x60	Shared	100	100	Yes	Yes	Yes	Yes	4	6
206	5x47	6x52	Shared	100	100	No	No	Yes	Yes	7	6
207	5x49	5x50	Shared	100	100	No	No	No	No	5	8
208	5x58	6x37	Shared	100	100	Yes	No	No	No	9	8
209	5x58	6x38	Shared	100	100	Yes	No	No	No	9	5
210	5x62	6x35	Shared	100	100	No	No	No	No	5	7
211	5x68	6x27	Shared	100	100	No	Yes	Yes	No	6	4
212	5x69	6x24	Shared	100	10	No	No	No	Yes	5	3
213	5x69	6x27	Shared	100	100	No	No	Yes	No	5	4
214	6x24	6x28	Shared	100	100	No	Yes	No	No	3	4
215	6x31	6x35	Shared	100	100	No	No	No	No	5	7
216	6x32	7x56	Shared	100	100	No	No	No	Yes	8	7
217	6x36	7x56	Shared	100	100	No	No	No	Yes	8	7
218	6x39	7x56	Shared	100	100	No	No	No	Yes	6	7
219	6x40	7x49	Shared	100	100	No	No	No	Yes	8	9
220	6x40	7x52	Shared	100	100	No	No	No	No	8	8
221	6x40	7x53	Shared	100	100	No	No	Yes	Yes	8	9
222	6x44	6x48	Shared	100	100	Yes	Yes	Yes	Yes	9	8
223	6x44	7x45	Shared	100	100	Yes	Yes	No	No	9	9
224	6x47	7x45	Shared	100	100	No	No	No	No	8	9
225	6x48	7x41	Shared	100	100	Yes	Yes	No	No	8	7
226	6x48	Lig	Shared	100	100	Yes	Yes	Yes	Yes	8	0
227	6x50	7x40	Shared	100	100	No	No	No	No	9	7
228	6x51	Lig	Shared	100	100	No	No	Yes	Yes	5	0
229	6x52	Lig	Shared	100	100	Yes	Yes	Yes	Yes	6	0
230	6x54	7x34	Shared	100	100	No	No	No	No	5	4
231	6x55	Lig	Shared	100	100	No	No	Yes	Yes	5	0
232	6x56	6x60	Shared	100	100	No	No	Yes	Yes	6	6
233	6x58	E3.H264	Shared	100	100	No	No	Yes	Yes	4	2
234	6x59	6x60	Shared	100	100	Yes	Yes	Yes	Yes	3	6
235	6x61	E3.C262	Shared	100	100	No	No	No	No	4	1
236	7x34	E3.H264	Shared	100	100	No	No	Yes	Yes	4	2
237	7x30	7x32	Shared	100	100	No	No	No	No	3	1
238	7x30	7x33	Shared	100	100	No	No	Yes	Yes	3	4
239	7x31	7x35	Shared	100	100	No	No	No	Yes	3	3
240	7x32	7x33	Shared	100	100	No	No	Yes	Yes	1	4
241	7x34	Lig	Shared	100	100	No	No	Yes	Yes	4	0
242	7x38	7x42	Shared	100	100	No	No	Yes	Yes	4	6
243	7x38	Lig	Shared	100	100	No	No	Yes	Yes	4	0
244	7x49	7x53	Shared	100	100	No	Yes	Yes	Yes	9	9
245	7x53	8x50	Shared	100	100	Yes	Yes	Yes	Yes	9	8
246	8x47	8x50	Shared	100	100	No	No	Yes	Yes	8	8
247	8x48	8x51	Shared	100	100	No	No	No	No	4	8
248	8x48	8x52	Shared	100	100	No	No	No	No	4	4
249	8x50	8x54	Shared	100	100	Yes	Yes	No	Yes	8	6
250	8x51	8x55	Shared	100	100	No	No	No	No	8	5
251	8x55	8x59	Shared	100	100	No	No	No	No	5	5
252	3x56	I2x52	Shared	100	100	No	No	No	No	5	5
253	3x26	4x61	Shared	30.7692	100	No	No	No	No	6	5
254	3x26	E2.V171	Shared	46.1538	100	No	No	No	No	6	4
255	1x51	2x51	Shared	46.1538	100	No	No	No	No	4	7
256	6x47	7x40	Shared	46.1538	100	No	No	No	No	8	7
257	2x66	E2x51	Shared	76.9231	70	No	No	Yes	No	4	4
258	1x47	2x55	Shared	38.4615	100	No	No	No	No	6	5
259	6x25	6x29	Shared	61.5385	50	No	No	No	No	4	6
260	E2.G147	E2.Q148	Shared	61.5385	50	No	No	No	No	3	3
261	I1x48	I1x51	Shared	23.0769	100	No	No	No	No	5	7
262	3x29	E2x52	Shared	7.69231	0	No	No	Yes	Yes	5	4
263	E2.A154	E2.C159	Shared	61.5385	30	No	No	No	No	1	3
264	6x51	7x37	Shared	30.7692	80	No	No	No	No	5	6
265	6x43	7x52	Shared	0	10	Yes	No	No	No	7	8
266	5x57	5x61	Shared	23.0769	40	No	No	No	No	7	9
267	1x50	2x51	Shared	0	10	Yes	Yes	No	No	9	7
268	2x60	7x42	Shared	7.69231	10	No	No	Yes	Yes	5	6
269	1x42	7x43	Shared	15.3846	30	No	Yes	No	No	7	5
270	7x54	8x54	Shared	0	0	No	No	No	Yes	7	6
271	6x43	7x48	Shared	46.1538	60	Yes	No	No	No	7	6
272	3x41	4x52	Shared	23.0769	100	Yes	Yes	No	No	5	4
273	E2.A165	E2.K153	Shared	23.0769	20	No	No	Yes	No	3	4
274	3x52	3x56	Shared	7.69231	10	Yes	No	No	No	5	5
275	2x41	4x39	Shared	0	10	No	No	No	No	5	1
276	5x62	6x34	Shared	0	0	No	No	No	No	5	7
277	5x55	5x59	Shared	38.4615	100	No	No	No	No	4	4
278	1x44	1x48	Shared	7.69231	20	No	No	No	No	4	5
279	4x48	4x52	Shared	0	0	No	No	No	No	3	4
280	1x57	8x50	Shared	0	0	No	No	Yes	Yes	7	8
281	4x63	E2.N144	Shared	46.1538	20	No	No	No	No	4	4
282	2x41	I1x51	Shared	38.4615	30	No	No	No	No	5	7
283	2x49	4x50	Shared	0	10	No	No	Yes	No	8	9
284	6x54	7x33	Shared	7.69231	20	No	No	Yes	Yes	5	4
285	6x53	6x57	Shared	0	0	No	No	No	No	5	4
286	1x58	1x59	Shared	15.3846	20	No	No	No	No	3	5
287	5x49	5x53	Shared	15.3846	10	No	No	No	No	5	6
288	3x43	6x41	Shared	15.3846	100	No	No	No	No	8	8
289	3x46	6x37	Shared	15.3846	100	No	No	No	No	8	8
290	E1x51	E2.Q157	Shared	23.0769	20	No	No	Yes	Yes	2	3
291	5x48	5x52	Shared	30.7692	30	No	No	No	No	4	3
292	4x38	4x39	Shared	7.69231	10	No	No	No	No	7	1
293	1x54	2x44	Shared	7.69231	10	No	No	No	No	7	5
294	5x65	6x31	Shared	7.69231	10	No	No	No	No	8	5
295	E2.P149	E2.Q148	Shared	7.69231	10	No	No	No	No	5	3
296	6x61	E3.P260	Shared	0	0	No	No	No	No	4	1
297	5x56	5x59	Shared	15.3846	40	No	No	No	No	4	4
298	2x38	4x39	Shared	0	10	No	No	No	No	6	1
299	2x65	2x66	Shared	0	20	No	No	No	No	5	4
300	1x46	7x46	Shared	0	0	No	No	No	No	7	9
301	1x48	1x49	Shared	0	0	No	No	No	No	5	9
302	6x45	6x49	Shared	0	40	No	No	No	No	5	6
303	5x63	5x66	Shared	7.69231	30	No	No	No	No	4	5
304	1x29	1x33	Shared	15.3846	10	No	No	No	No	5	4
305	7x51	7x55	Shared	0	30	No	No	No	No	6	6
306	1x30	1x31	Shared	0	0	No	Yes	No	No	4	5
307	6x49	6x53	Shared	0	30	No	No	No	No	6	5
308	7x47	7x51	Shared	0	0	No	No	No	No	7	6
309	3x56	I2x50	Shared	0	0	No	No	No	No	5	8
310	1x55	8x61	Shared	15.3846	100	No	No	No	No	4	0
311	1x27	1x28	Shared	0	0	No	No	No	No	6	6
312	6x26	6x30	Shared	0	10	No	No	No	No	5	7
313	7x33	7x36	Shared	0	0	Yes	Yes	No	No	4	5
314	5x46	5x461	Shared	0	0	No	No	Yes	Yes	3	5
315	1x34	1x38	Shared	0	0	No	No	No	No	5	5
316	E2.Q157	E2.S156	Shared	0	0	Yes	Yes	No	No	3	4
317	4x38	4x40	Shared	0	10	No	No	No	No	7	5
318	1x32	1x36	Shared	0	30	No	No	No	No	4	6
319	8x60	8x61	Shared	15.3846	100	No	No	No	No	4	0
320	4x44	4x47	Shared	0	0	No	No	No	No	3	4
321	6x61	E3.D261	Shared	0	10	No	No	No	No	4	1
322	6x43	6x46	Shared	0	0	Yes	No	No	No	7	5
323	1x29	1x30	Shared	0	0	No	No	No	Yes	5	4
324	E2.E161	E2.G162	Shared	23.0769	0	No	No	No	No	3	4
325	5x67	6x27	Shared	7.69231	10	No	No	Yes	No	4	4
326	8x58	8x62	Shared	15.3846	10	No	No	No	No	6	0
327	8x49	8x52	Shared	0	10	Yes	Yes	No	No	6	4
328	6x22	6x25	Shared	7.69231	20	No	No	No	No	1	4
329	4x43	4x44	Shared	0	0	No	No	No	No	3	3
330	6x21	6x24	Shared	0	30	No	No	No	Yes	4	3
331	I2x51	I2x52	Shared	7.69231	20	No	No	No	No	6	5
332	8x58	8x63	Shared	7.69231	0	No	No	No	No	6	0
333	2x41	4x43	Shared	7.69231	30	No	No	No	No	5	3
334	E2.G158	E2.Q157	Shared	7.69231	0	No	No	Yes	Yes	2	3
335	4x59	4x62	Shared	0	20	Yes	No	No	No	6	4
336	6x57	E3.C262	Shared	0	10	No	No	No	No	4	1
337	1x37	1x38	Shared	0	10	No	No	No	No	4	5
338	3x50	6x33	Shared	0	10	Yes	Yes	No	No	9	8
339	1x59	8x57	a2a_off	0	100	No	No	No	No	5	6
340	2x46	3x39	a2a_off	0	100	No	No	No	No	9	9
341	2x50	3x39	a2a_off	0	100	No	Yes	No	No	9	9
342	2x50	7x49	a2a_off	0	100	No	Yes	No	Yes	9	9
343	2x54	2x57	a2a_off	0	100	No	No	Yes	Yes	7	6
344	2x63	E2x50	a2a_off	0	100	No	No	No	No	4	9
345	3x30	3x33	a2a_off	0	100	No	No	No	Yes	5	4
346	3x50	I2x53	a2a_off	0	100	Yes	Yes	Yes	Yes	9	7
347	5x36	E2.V172	a2a_off	0	100	No	Yes	No	No	4	3
348	5x40	E2.V172	a2a_off	0	100	Yes	Yes	No	No	6	3
349	5x41	6x60	a2a_off	0	100	No	No	Yes	Yes	5	6
350	5x54	6x41	a2a_off	0	100	No	No	No	No	8	8
351	6x35	7x56	a2a_off	0	100	No	No	No	Yes	7	7
352	6x48	7x45	a2a_off	0	100	Yes	Yes	No	No	8	9
353	7x35	Lig	a2a_off	0	100	No	Yes	Yes	Yes	3	0
354	7x41	7x42	a2a_off	0	100	No	No	Yes	Yes	7	6
355	2x64	7x35	a2a_off	0	100	No	No	No	Yes	3	3
356	E3.H264	Lig	a2a_off	0	100	Yes	Yes	Yes	Yes	2	0
357	1x42	2x57	a2a_off	0	10	No	Yes	Yes	Yes	7	6
358	1x36	1x40	a2a_off	0	0	No	No	No	No	6	5
359	1x38	1x42	a2a_off	0	50	No	No	No	Yes	5	7
360	6x39	7x52	a2a_off	0	30	No	No	No	No	6	8
361	6x54	E3.A265	a2a_off	0	20	No	No	No	No	5	4
362	5x51	6x45	a2a_off	0	30	No	No	No	No	6	5
363	E2.N154	E2.V164	a2a_off	0	30	No	No	No	No	0	4
364	5x47	5x51	a2a_off	0	10	No	No	No	No	7	6
365	3x54	5x68	a2a_off	0	20	Yes	No	No	Yes	8	6
366	8x54	8x58	a2a_off	0	10	No	Yes	No	No	6	6
367	1x42	7x47	a2a_off	0	0	No	Yes	No	No	7	7
368	6x22	6x26	a2a_off	0	20	No	No	No	No	1	5
369	5x62	5x66	a2a_off	0	20	No	No	No	No	5	5
370	8x56	8x60	a2a_off	0	20	No	No	No	No	4	4
371	3x55	5x64	a2a_off	0	10	No	No	No	No	6	6
372	E2.P149	E2.V164	a2a_off	0	0	No	No	No	No	5	4
373	E2.E161	E2.G160	a2a_off	0	10	No	No	No	No	3	1
374	5x72	I3.Q214	a2a_off	0	10	No	No	No	No	0	0
375	I3.L216	I3.Q214	a2a_off	0	10	No	No	No	No	0	0
376	5x72	6x24	a2a_off	0	10	No	No	No	Yes	0	3
377	8x61	8x64	a2a_off	0	10	No	No	No	No	0	0
378	6x23	6x26	a2a_off	0	10	No	No	No	No	3	5
379	1x30	1x32	a2a_off	0	10	No	Yes	No	No	4	4
380	5x55	6x41	a2a_off	0	10	No	No	No	No	4	8
381	6x42	6x45	a2a_off	0	0	No	No	No	No	5	5
382	8x64	8x65	a2a_off	0	0	No	No	No	No	0	0
383	I2x54	I2x55	a2a_off	0	10	No	No	No	No	5	5
384	5x68	I3.M211	a2a_off	0	0	No	Yes	No	No	6	0
385	5x70	5x73	a2a_off	0	0	No	No	No	No	0	0
386	5x66	I3.K209	a2a_off	0	0	No	No	No	No	5	0
387	I3.G218	I3.P217	a2a_off	0	0	No	No	No	No	0	0
388	I3.G218	I3.L216	a2a_off	0	0	No	No	No	No	0	0
389	3x23	3x24	a2a_off	0	0	No	No	No	No	2	6
390	I3.P215	I3.Q214	a2a_off	0	0	No	No	No	No	0	0
391	4x52	4x55	a2a_off	0	0	No	No	No	No	4	4
392	5x68	5x71	a2a_off	0	0	No	Yes	No	No	6	0
393	5x73	6x24	a2a_off	0	0	No	No	No	Yes	0	3

Orange: nodes, hubs and links specific of a2a_off_allo network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of a2a_off network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	a2a_off_allo Avg Int. Strength	a2a_off Avg Int. Strength	a2a_off_allo Num Of Links	a2a_off Num Of Links	ConSurf
1	3x40	a2a_off_allo	61.5385	30	4	3	7
2	3x52	a2a_off_allo	0	0	4	2	5
3	3x54	a2a_off_allo	0	0	4	3	8
4	4x50	a2a_off_allo	0	0	4	3	9
5	4x59	a2a_off_allo	0	0	4	3	6
6	E2.K153	a2a_off_allo	23.0769	0	4	3	4
7	E2x51	a2a_off_allo	0	0	4	2	4
8	5x42	a2a_off_allo	0	20	4	3	4
9	5x43	a2a_off_allo	46.1538	20	4	3	5
10	5x58	a2a_off_allo	15.3846	30	4	3	9
11	6x27	a2a_off_allo	0	10	4	3	4
12	6x43	a2a_off_allo	0	0	4	3	7
13	1x39	Shared	84.6154	100	5	5	6
14	1x50	Shared	0	10	4	4	9
15	1x60	Shared	100	100	4	4	6
16	I1x50	Shared	100	90	5	5	8
17	2x40	Shared	76.9231	50	4	4	8
18	2x42	Shared	46.1538	20	4	4	7
19	2x57	Shared	100	80	4	6	6
20	E1x50	Shared	76.9231	70	4	4	7
21	3x31	Shared	76.9231	80	4	4	5
22	3x37	Shared	100	100	5	5	5
23	3x41	Shared	15.3846	20	4	4	5
24	3x49	Shared	76.9231	70	4	4	9
25	3x50	Shared	61.5385	80	4	5	9
26	I2x53	Shared	92.3077	80	5	5	7
27	I2x57	Shared	84.6154	70	5	5	7
28	E2.W143	Shared	100	80	4	4	5
29	E2.Q157	Shared	7.69231	0	4	4	3
30	E2x52	Shared	7.69231	0	5	4	4
31	5x39	Shared	100	100	7	7	6
32	5x40	Shared	84.6154	80	6	5	6
33	5x44	Shared	23.0769	50	5	4	5
34	5x45	Shared	84.6154	80	4	4	4
35	5x461	Shared	0	0	4	4	5
36	6x44	Shared	100	100	5	5	9
37	6x48	Shared	76.9231	90	4	5	8
38	6x52	Shared	84.6154	60	4	4	6
39	6x59	Shared	100	90	4	4	3
40	6x60	Shared	84.6154	90	4	5	6
41	E3.H264	Shared	15.3846	30	4	4	2
42	7x33	Shared	0	10	4	4	4
43	7x42	Shared	38.4615	80	4	5	6
44	7x53	Shared	100	90	6	5	9
45	8x49	Shared	0	20	4	4	6
46	8x50	Shared	100	90	6	6	8
47	Lig	Shared	100	100	9	11	0
48	1x30	a2a_off	0	0	3	4	4
49	1x42	a2a_off	0	0	2	4	7
50	2x50	a2a_off	15.3846	40	3	4	9
51	3x33	a2a_off	46.1538	50	3	4	4
52	5x36	a2a_off	76.9231	90	3	4	4
53	5x68	a2a_off	0	0	1	4	6
54	6x24	a2a_off	0	0	3	5	3
55	7x35	a2a_off	7.69231	30	2	4	3
56	7x49	a2a_off	23.0769	30	3	4	9
57	7x56	a2a_off	7.69231	20	3	4	7
58	8x54	a2a_off	0	0	3	4	6

Orange: nodes, hubs and links specific of a2a_off_allo network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of a2a_off network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	a2a_off_allo Recurrence	a2a_off Recurrence	a2a_off_allo Hub1?	a2a_off Hub1?	a2a_off_allo Hub2?	a2a_off Hub2?	ConSurf1	ConSurf2
1	1x39	2x61	a2a_off_allo	11.7575	9.98402	Yes	Yes	No	No	6	6
2	7x38	7x42	a2a_off_allo	29.6253	3.83379	No	No	Yes	Yes	4	6
3	7x38	Lig	a2a_off_allo	30.6757	4.60593	No	No	Yes	Yes	4	0
4	3x39	Na	a2a_off_allo	75.3123	0	No	No	No	No	9	0
5	2x50	Na	a2a_off_allo	75.6355	0	No	Yes	No	No	9	0
6	1x50	2x50	a2a_off_allo	99.8515	4.98527	Yes	Yes	No	Yes	9	9
7	1x50	7x50	a2a_off_allo	51.1094	3.06741	Yes	Yes	No	No	9	9
8	1x50	2x47	a2a_off_allo	49.7336	0.87998	Yes	Yes	No	No	9	9
9	1x53	2x47	a2a_off_allo	49.6724	0	No	No	No	No	9	9
10	1x53	7x53	a2a_off_allo	100	2.65342	No	No	Yes	Yes	9	9
11	1x52	8x54	a2a_off_allo	11.7444	8.87682	No	No	No	Yes	6	6
12	1x53	7x50	a2a_off_allo	50.8648	2.12004	No	No	No	No	9	9
13	3x40	5x47	a2a_off_allo	25.2948	0	Yes	No	No	No	7	7
14	2x45	3x42	a2a_off_allo	31.1539	0.9493	No	No	No	No	9	7
15	2x46	3x42	a2a_off_allo	31.226	0	No	No	No	No	9	7
16	2x66	E2x51	a2a_off_allo	17.2388	9.5007	No	No	Yes	No	4	4
17	E2.K153	E2x51	a2a_off_allo	12.7773	0	Yes	No	Yes	No	4	4
18	E2.A165	E2.K153	a2a_off_allo	10.5128	7.09953	No	No	Yes	No	3	4
19	5x42	5x461	a2a_off_allo	12.4367	6.05203	Yes	No	Yes	Yes	4	5
20	3x49	I2x53	a2a_off_allo	22.3554	5.36653	Yes	Yes	Yes	Yes	9	7
21	3x52	I2x53	a2a_off_allo	18.7303	0	Yes	No	Yes	Yes	5	7
22	3x48	3x52	a2a_off_allo	15.0834	0	No	No	Yes	No	6	5
23	3x44	3x48	a2a_off_allo	11.3055	0.916566	No	No	No	No	7	6
24	3x52	I2x57	a2a_off_allo	18.9269	9.1541	Yes	No	Yes	Yes	5	7
25	5x36	E2.W143	a2a_off_allo	10.1197	0.454432	No	Yes	Yes	Yes	4	5
26	3x54	6x27	a2a_off_allo	12.2161	0	Yes	No	Yes	No	8	4
27	7x34	Lig	a2a_off_allo	11.2421	6.31968	No	No	Yes	Yes	4	0
28	3x52	3x56	a2a_off_allo	18.9094	7.3306	Yes	No	No	No	5	5
29	3x56	I2x52	a2a_off_allo	11.3579	3.67204	No	No	No	No	5	5
30	3x37	5x461	a2a_off_allo	13.0045	6.96474	Yes	Yes	Yes	Yes	5	5
31	5x44	5x47	a2a_off_allo	16.8392	0.231067	Yes	Yes	No	No	5	7
32	1x39	7x42	Shared	24.0632	10.0476	Yes	Yes	Yes	Yes	6	6
33	6x48	Lig	Shared	52.1445	47.3379	Yes	Yes	Yes	Yes	8	0
34	6x44	6x48	Shared	54.0597	68.6288	Yes	Yes	Yes	Yes	9	8
35	3x39	6x44	Shared	74.9913	100	No	No	Yes	Yes	9	9
36	2x50	7x46	Shared	58.2678	30.6818	No	Yes	No	No	9	9
37	2x53	7x46	Shared	52.531	29.696	No	No	No	No	6	9
38	2x53	3x35	Shared	49.5829	28.1882	No	No	No	No	6	7
39	3x31	3x35	Shared	47.5956	27.1638	Yes	Yes	No	No	5	7
40	7x53	8x50	Shared	63.9872	53.2109	Yes	Yes	Yes	Yes	9	8
41	8x50	8x54	Shared	13.7491	13.2324	Yes	Yes	No	Yes	8	6
42	8x50	I1x50	Shared	11.1875	10.7658	Yes	Yes	Yes	Yes	8	8
43	2x43	7x53	Shared	38.8518	27.8994	No	No	Yes	Yes	8	9
44	2x40	2x43	Shared	38.1005	27.1407	Yes	Yes	No	No	8	8
45	2x37	2x40	Shared	77.0375	54.2796	No	No	Yes	Yes	7	8
46	2x40	8x50	Shared	39.5397	28.0997	Yes	Yes	Yes	Yes	8	8
47	2x37	2x39	Shared	75.273	52.5542	No	No	No	No	7	8
48	2x39	3x49	Shared	68.4464	40.8777	No	No	Yes	Yes	8	9
49	3x49	I2x57	Shared	44.7283	34.0554	Yes	Yes	Yes	Yes	9	7
50	2x38	I2x57	Shared	22.7638	21.8031	No	No	Yes	Yes	6	7
51	3x40	6x44	Shared	30.7084	45.1351	Yes	No	Yes	Yes	7	9
52	3x37	3x40	Shared	20.8508	42.5471	Yes	Yes	Yes	No	5	7
53	3x37	4x53	Shared	24.9345	36.9264	Yes	Yes	No	No	5	7
54	3x38	4x53	Shared	26.2819	36.5779	No	No	No	No	6	7
55	3x38	4x50	Shared	26.1356	35.7923	No	No	Yes	No	6	9
56	2x45	4x50	Shared	25.7294	34.2095	No	No	Yes	No	9	9
57	2x45	4x46	Shared	33.401	32.6112	No	No	No	No	9	8
58	2x42	4x46	Shared	32.5057	31.8064	Yes	Yes	No	No	7	8
59	2x42	3x46	Shared	29.7847	29.3397	Yes	Yes	No	No	7	8
60	7x49	7x53	Shared	29.8917	77.625	No	Yes	Yes	Yes	9	9
61	3x27	3x31	Shared	39.461	25.221	No	No	Yes	Yes	4	5
62	3x27	4x61	Shared	35.0847	22.839	No	No	No	No	4	5
63	3x26	4x61	Shared	34.2418	22.5155	No	No	No	No	6	5
64	3x26	E2.V171	Shared	26.747	14.7787	No	No	No	No	6	4
65	3x25	E2.V171	Shared	25.7621	14.2742	No	No	No	No	9	4
66	3x25	E2x50	Shared	23.6788	13.6657	No	No	No	No	9	9
67	E1x50	E2x50	Shared	22.6939	12.5412	Yes	Yes	No	No	7	9
68	2x65	E1x50	Shared	19.4794	10.7716	No	No	Yes	Yes	5	7
69	2x65	2x66	Shared	18.3613	10.1381	No	No	No	No	5	4
70	3x46	6x37	Shared	28.8697	28.5194	No	No	No	No	8	8
71	5x58	6x37	Shared	28.0813	27.6683	Yes	No	No	No	9	8
72	3x47	5x58	Shared	21.6785	26.1356	No	No	Yes	No	9	9
73	3x47	5x57	Shared	20.7263	25.2999	No	No	No	No	9	7
74	5x57	5x61	Shared	19.7698	24.4604	No	No	No	No	7	9
75	2x38	4x39	Shared	19.0186	18.2139	No	No	No	No	6	1
76	3x54	5x61	Shared	15.8914	20.1798	Yes	No	No	No	8	9
77	2x41	4x39	Shared	11.4627	10.9738	No	No	No	No	5	1
78	2x46	7x49	Shared	31.3002	39.6723	No	No	No	Yes	9	9
79	2x50	3x39	a2a_off	0	60.6897	No	Yes	No	No	9	9
80	2x46	3x39	a2a_off	0	39.784	No	No	No	No	9	9
81	2x50	7x49	a2a_off	0	52.1326	No	Yes	No	Yes	9	9
82	5x40	Lig	a2a_off	9.25708	10.0687	Yes	Yes	Yes	Yes	6	0
83	6x52	Lig	a2a_off	9.76371	17.5168	Yes	Yes	Yes	Yes	6	0
84	5x47	6x52	a2a_off	7.79394	10.8005	No	No	Yes	Yes	7	6
85	6x40	7x49	a2a_off	1.98725	13.3249	No	No	No	Yes	8	9
86	6x40	7x52	a2a_off	9.27455	15.6143	No	No	No	No	8	8
87	6x39	7x52	a2a_off	0	11.6785	No	No	No	No	6	8
88	6x39	7x56	a2a_off	3.40889	10.683	No	No	No	Yes	6	7
89	3x54	5x68	a2a_off	0	14.2568	Yes	No	No	Yes	8	6
90	5x68	6x27	a2a_off	1.04167	11.8865	No	Yes	Yes	No	6	4
91	5x69	6x27	a2a_off	7.21305	10.2035	No	No	Yes	No	5	4
92	7x41	7x42	a2a_off	0	20.4976	No	No	Yes	Yes	7	6
93	5x47	5x51	a2a_off	0	10.0495	No	No	No	No	7	6
94	6x48	7x41	a2a_off	1.08534	21.2909	Yes	Yes	No	No	8	7
95	2x57	7x42	a2a_off	3.47004	12.8338	Yes	Yes	Yes	Yes	6	6

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
1x35	2x64	Shared	4.326	4.40538	1	0	2	2
1x35	7x35	Shared	14.795	19.7792	1	0	2	1
3x33	5x39	Shared	3.635	3.79	1	1	2	2
3x33	5x40	Shared	3.958	3.91461	1	1	2	1
3x33	5x43	Shared	6.73	7.18462	1	1	2	2
3x36	6x48	Shared	8.946	4.48538	0	0	2	1
E2.V172	E2x52	Shared	11.799	12.8069	1	0	2	1
5x40	E2x52	Shared	5.597	7.07846	1	1	1	1
E2x52	Lig	Shared	31.103	36.6846	1	1	1	0
5x37	E2.E169	Shared	5.414	3.85	0	0	2	1
E2.E169	E3.H264	Shared	9.234	7.48154	1	0	1	1
E2.E169	Lig	Shared	6.549	6.27	1	0	1	0
5x40	E2.V172	a2a_off	3.192	0	1	1	1	2
5x37	6x55	Shared	7.149	7.55154	0	0	2	1
5x39	5x40	Shared	3.83	3.59	1	1	2	1
5x39	5x43	Shared	6.86	7.69231	1	1	2	2
5x40	Lig	Shared	5.101	4.83692	1	1	1	0
5x43	6x52	Shared	3.573	3.92692	1	1	2	1
5x44	5x47	Shared	3.406	3.32538	1	1	2	2
5x44	6x52	Shared	24.89	25.4115	1	1	2	1
5x47	6x52	Shared	6.505	6.49385	1	1	2	1
6x44	6x48	Shared	13.33	14.7262	1	0	2	1
6x44	7x45	Shared	8.338	8.55308	1	0	2	2
6x48	7x41	Shared	11.936	9.13692	1	0	1	2
6x48	7x45	a2a_off	3.729	0	1	0	1	2
6x48	Lig	Shared	5.333	4.58308	1	0	1	0
6x51	Lig	Shared	15.555	15.5615	0	0	1	0
6x52	Lig	Shared	5.87	4.95154	1	1	1	0
6x54	7x34	Shared	3.355	3.47846	0	0	2	1
6x55	Lig	Shared	10.507	11.19	0	1	1	0
6x58	E3.H264	Shared	9.994	10.3192	0	0	2	1
7x34	E3.H264	Shared	3.808	3.33231	1	0	1	1
7x31	7x35	Shared	6.799	11.9915	0	0	2	1
7x34	Lig	Shared	4.67	4.98538	1	0	1	0
7x35	Lig	a2a_off	4.406	0	1	0	1	0
7x38	7x42	Shared	3.847	3.98	0	0	1	2
7x38	Lig	Shared	13.11	10.2654	0	0	1	0
7x41	7x42	a2a_off	3.623	0	0	0	2	2
2x64	7x35	a2a_off	3.307	0	1	0	2	1
E3.H264	Lig	a2a_off	4.686	0	1	0	1	0
6x51	7x37	Shared	3.151	2.90923	0	0	1	2
3x29	E2x52	Shared	2.493	2.98385	0	0	2	1
5x40	5x43	a2a_off_allo	0	3.55846	1	1	1	2
5x40	6x55	a2a_off_allo	0	3.34231	1	1	1	1
E2.172	E2x52	a2a_off_allo	0	1.10923	0	0	2	1
E2.169	E3.H264	a2a_off_allo	0	0.757692	0	0	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	a2a_off_allo	6ZDR-A_2A-HMS1413f12-Na 6GT3-A_2A-Imaradenant-Na 8CU7-A_2A-LJ-4517-Na 5OLV-A_2A-LUAA41063-Na 5N2R-A_2A-PubChem 92460631; psb36-Na 5MZJ-A_2A-Theophylline-Na 5OLO-A_2A-Tozadenant-Na 5OLH-A_2A-Vipadenant-Na 5NM4-A_2A-ZM241385-Na 8GNE-A_2A-KW-6356-Na 8JWZ-A_2A-AB928-Na 5MZP-A_2A-Caffeine-Na 8CIC-A_2A-Etrumadenant-Na
	a2a_off	8C9W-A_2A-Etrumadenant 3UZA-A_2A-GTPL9236 8GNG-A_2A-Istradefylline 5UIG-A_2A-J3.651.884G 8CU6-A_2A-LJ-4517 7PX4-A_2A-PSB-2113 7PYR-A_2A-PSB-2115 8DU3-A_2A-PubChem 105526064 8JWY-A_2A-PubChem 168451710 5K2D-A_2A-ZM241385

Network Difference
Value	a2a_off_allo	a2a_off
I_min	3.27846	3.152
Number of Linked Nodes	299	307
Number of Specific Nodes	8 (2.68%)	16 (5.21%)
Number of Shared Nodes	291 (97.32%)	291 (94.79%)
Number of Links	338	349
Number of Specific Links	44 (13.02%)	55 (15.76%)
Number of Shared Links	294 (86.98%)	294 (84.24%)
Number of Hubs	47	46
Number of Specific Hubs	12 (25.53%)	11 (23.91%)
Number of Shared Hubs	35 (74.47%)	35 (76.09%)
Average % Shared Neighbours (Jaccard)	75.41
Average % Shared Neighbours (Otsuka)	80.79
Average % Shared Neighbours (Overlap Coefficient)	86.78
Average % Shared Cliques (k3-6)	63.75
Graphlets Similarity	0.654137

Paths Difference
Value	a2a_off_allo	a2a_off
Number Of Nodes in MetaPath	76	63
Specific Nodes in MetaPath	24 (31.58%)	11 (17.46%)
Shared Nodes in MetaPath	291 (97.32%)	291 (97.32%)
Number Of Links MetaPath	78	64
Specific Links in MetaPath	31 (39.74%)	17 (26.56%)
Shared Links in MetaPath	294 (86.98%)	294 (86.98%)
Number of Shortest Paths	87516	81881
Length Of Smallest Path	3	3
Average Path Length	18.0579	16.999
Length of Longest Path	45	50
Minimum Path Strength	0.155769	0.386
Average Path Strength	6.04627	5.8926
Maximum Path Strength	22.3492	20.621
Minimum Path Correlation	0.7	0.703
Average Path Correlation	0.923754	0.917515
Maximum Path Correlation	0.99	0.99
Minimum % Of Corr. Nodes	2.94118	2.27273
Average % Of Corr. Nodes	39.2419	39.2425
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	37.9194	42.3514
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download a2a_off_ortoallo.zip<

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