psnGPCR

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Orange: nodes, hubs and links specific of adenosine_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of adenosine_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	adenosine_off Int. Strength	adenosine_on Int. Strength	adenosine_off Hub1?	adenosine_on Hub1?	adenosine_off Hub2?	adenosine_on Hub2?	ConSurf1	ConSurf2
1	1x35	Lig	adenosine_off	100	0	Yes	Yes	Yes	Yes	5	0
2	1x39	7x39	adenosine_off	100	0	Yes	Yes	No	Yes	6	5
3	1x49	7x50	adenosine_off	100	0	No	No	No	No	8	9
4	1x50	2x47	adenosine_off	100	0	Yes	No	No	No	9	9
5	1x53	7x50	adenosine_off	100	0	No	No	No	No	9	9
6	1x53	7x53	adenosine_off	100	0	No	No	Yes	Yes	9	9
7	1x55	8x57	adenosine_off	100	0	Yes	No	No	No	4	7
8	1x55	8x61	adenosine_off	100	0	Yes	No	No	No	4	6
9	1x60	I1x49	adenosine_off	100	0	Yes	No	No	No	6	6
10	1x60	8x49	adenosine_off	100	0	Yes	No	No	No	6	6
11	2x37	3x53	adenosine_off	100	0	No	No	Yes	No	7	8
12	2x38	3x49	adenosine_off	100	0	No	No	Yes	No	6	9
13	2x39	3x50	adenosine_off	100	0	No	No	Yes	No	8	9
14	2x42	3x46	adenosine_off	100	0	Yes	Yes	No	No	8	9
15	2x43	7x53	adenosine_off	100	0	No	No	Yes	Yes	8	9
16	2x45	4x50	adenosine_off	100	0	No	No	No	No	9	9
17	2x46	3x39	adenosine_off	100	0	No	Yes	No	No	9	9
18	2x53	3x35	adenosine_off	100	0	No	No	No	No	8	7
19	2x54	2x57	adenosine_off	100	0	No	No	Yes	Yes	7	6
20	2x551	2x59	adenosine_off	100	0	No	No	No	No	5	5
21	2x56	3x32	adenosine_off	100	0	No	No	No	No	6	6
22	2x63	E2x50	adenosine_off	100	0	No	No	No	No	3	9
23	3x24	E1x52	adenosine_off	100	0	No	No	No	No	5	7
24	3x21	3x23	adenosine_off	100	0	No	No	No	No	6	1
25	3x23	3x24	adenosine_off	100	0	No	No	No	No	1	5
26	3x23	E2	adenosine_off	100	0	No	No	Yes	Yes	1	3
27	3x30	4x60	adenosine_off	100	0	No	No	No	No	6	4
28	3x33	5x40	adenosine_off	100	0	No	No	Yes	Yes	4	5
29	3x36	6x48	adenosine_off	100	0	No	No	Yes	Yes	6	8
30	3x37	3x40	adenosine_off	100	0	Yes	Yes	No	Yes	6	8
31	3x39	6x44	adenosine_off	100	0	No	No	Yes	Yes	9	9
32	3x41	4x52	adenosine_off	100	0	No	No	No	No	4	4
33	3x44	5x54	adenosine_off	100	0	No	No	No	No	7	8
34	3x46	6x37	adenosine_off	100	0	No	No	No	No	9	8
35	3x49	3x50	adenosine_off	100	0	Yes	No	Yes	No	9	9
36	3x49	I2x57	adenosine_off	100	0	Yes	No	No	No	9	7
37	3x50	3x53	adenosine_off	100	0	Yes	No	Yes	No	9	8
38	3x50	6x30	adenosine_off	100	0	Yes	No	Yes	Yes	9	6
39	3x50	6x33	adenosine_off	100	0	Yes	No	No	No	9	7
40	3x51	5x61	adenosine_off	100	0	No	No	No	No	7	9
41	3x53	6x30	adenosine_off	100	0	Yes	No	Yes	Yes	8	6
42	4x58	4x61	adenosine_off	100	0	No	No	No	Yes	4	5
43	5x40	E2x52	adenosine_off	100	0	Yes	Yes	No	Yes	5	4
44	5x37	6x58	adenosine_off	100	0	No	No	No	No	3	4
45	5x41	5x45	adenosine_off	100	0	No	No	No	No	4	4
46	5x41	6x56	adenosine_off	100	0	No	No	No	No	4	5
47	5x54	6x41	adenosine_off	100	0	No	No	No	No	8	8
48	5x58	6x38	adenosine_off	100	0	No	Yes	No	No	9	6
49	5x62	6x35	adenosine_off	100	0	No	No	No	No	6	7
50	5x65	6x31	adenosine_off	100	0	No	No	No	No	8	5
51	5x68	6x27	adenosine_off	100	0	No	No	No	No	7	1
52	5x69	6x27	adenosine_off	100	0	No	No	No	No	4	1
53	6x35	7x56	adenosine_off	100	0	No	No	Yes	No	7	7
54	6x40	7x49	adenosine_off	100	0	No	No	Yes	Yes	8	9
55	6x40	7x52	adenosine_off	100	0	No	No	No	No	8	8
56	6x44	7x45	adenosine_off	100	0	Yes	Yes	Yes	No	9	9
57	6x54	7x34	adenosine_off	100	0	No	No	No	No	4	4
58	6x59	6x60	adenosine_off	100	0	Yes	No	No	No	4	4
59	7x32	7x33	adenosine_off	100	0	No	No	No	No	1	4
60	7x35	Lig	adenosine_off	100	0	Yes	Yes	Yes	Yes	3	0
61	7x41	7x42	adenosine_off	100	0	No	No	Yes	Yes	7	7
62	7x49	7x53	adenosine_off	100	0	Yes	Yes	Yes	Yes	9	9
63	7x53	8x47	adenosine_off	100	0	Yes	Yes	No	No	9	8
64	7x53	8x50	adenosine_off	100	0	Yes	Yes	Yes	Yes	9	9
65	8x50	8x54	adenosine_off	100	0	Yes	Yes	Yes	No	9	7
66	8x58	8x63	adenosine_off	100	0	No	No	No	No	5	4
67	3x54	6x30	adenosine_off	100	0	Yes	No	Yes	Yes	9	6
68	5x38	E2	adenosine_off	100	0	No	No	Yes	Yes	3	3
69	6x26	6x30	adenosine_off	100	0	No	No	Yes	Yes	3	6
70	6x29	8x50	adenosine_off	100	0	No	No	Yes	Yes	6	9
71	6x52	Lig	adenosine_off	100	0	No	No	Yes	Yes	7	0
72	E3	Lig	adenosine_off	100	0	Yes	Yes	Yes	Yes	3	0
73	7x30	7x32	adenosine_off	100	0	No	No	No	No	4	1
74	E1x50	E2x50	adenosine_off	100	0	Yes	No	No	No	3	9
75	3x31	3x35	adenosine_off	100	0	No	No	No	No	4	7
76	E2	E3	adenosine_off	100	0	Yes	Yes	Yes	Yes	3	3
77	6x32	7x56	adenosine_off	100	0	No	No	Yes	No	7	7
78	8x55	8x59	adenosine_off	100	0	No	No	No	No	5	4
79	1x52	8x57	adenosine_off	75	0	No	No	No	No	7	7
80	1x57	I1x50	adenosine_off	55	0	No	No	Yes	Yes	8	8
81	3x43	5x54	adenosine_off	5	0	No	Yes	No	No	8	8
82	3x52	I2x57	adenosine_off	50	0	No	No	No	No	5	7
83	1x42	2x57	adenosine_off	25	0	No	No	Yes	Yes	7	6
84	5x69	6x24	adenosine_off	30	0	No	No	Yes	No	4	2
85	7x45	7x48	adenosine_off	50	0	Yes	No	No	No	9	6
86	5x62	5x66	adenosine_off	60	0	No	No	No	No	6	5
87	3x27	3x31	adenosine_off	50	0	No	No	No	No	4	4
88	5x47	5x51	adenosine_off	25	0	No	No	No	No	5	6
89	1x56	8x53	adenosine_off	75	0	No	No	No	Yes	8	6
90	1x47	2x54	adenosine_off	40	0	No	No	No	No	6	7
91	3x44	3x48	adenosine_off	50	0	No	No	No	No	7	6
92	5x51	6x45	adenosine_off	40	0	No	No	No	No	6	6
93	6x47	7x40	adenosine_off	25	0	No	No	No	No	8	7
94	5x44	6x49	adenosine_off	0	0	Yes	Yes	No	No	5	7
95	5x63	5x67	adenosine_off	50	0	No	No	No	No	4	4
96	3x55	3x56	adenosine_off	30	0	No	No	No	No	7	6
97	2x38	4x42	adenosine_off	50	0	No	No	No	No	6	7
98	1x47	2x55	adenosine_off	20	0	No	No	No	No	6	4
99	2x62	E1x50	adenosine_off	50	0	No	No	Yes	No	4	3
100	2x49	4x50	adenosine_off	0	0	No	No	No	No	8	9
101	7x54	8x54	adenosine_off	0	0	No	No	Yes	No	7	7
102	1x40	2x61	adenosine_off	0	0	No	No	No	No	4	6
103	2x41	4x46	adenosine_off	25	0	No	No	No	No	4	8
104	I2x51	I2x52	adenosine_off	10	0	No	No	Yes	No	6	5
105	6x32	8x48	adenosine_off	50	0	No	No	No	No	7	4
106	3x54	5x68	adenosine_off	10	0	Yes	No	No	No	9	7
107	7x55	7x56	adenosine_off	25	0	No	No	Yes	No	6	7
108	1x58	2x44	adenosine_off	50	0	No	No	No	No	3	5
109	6x21	6x24	adenosine_off	15	0	No	No	Yes	No	0	2
110	6x25	6x29	adenosine_off	25	0	No	No	No	No	3	6
111	2x41	4x43	adenosine_off	15	0	No	No	No	No	4	1
112	5x56	5x59	adenosine_off	20	0	No	No	No	No	4	3
113	1x44	1x48	adenosine_off	0	0	No	No	No	No	5	4
114	4x41	I2x56	adenosine_off	5	0	No	No	No	No	5	4
115	5x60	5x63	adenosine_off	25	0	No	No	No	No	4	4
116	1x31	7x35	adenosine_off	25	0	No	No	Yes	Yes	4	3
117	4x59	4x62	adenosine_off	5	0	No	No	No	No	6	4
118	8x54	8x58	adenosine_off	5	0	Yes	No	No	No	7	5
119	1x55	8x62	adenosine_off	0	0	Yes	No	No	No	4	3
120	2x41	I1x51	adenosine_off	15	0	No	No	No	No	4	7
121	6x22	6x26	adenosine_off	10	0	No	No	No	No	3	3
122	5x52	5x56	adenosine_off	0	0	No	No	No	No	3	4
123	I2x52	I2x55	adenosine_off	0	0	Yes	No	No	No	5	5
124	1x29	1x33	adenosine_off	0	0	No	No	No	No	6	5
125	1x29	1x30	adenosine_off	0	0	No	No	No	No	6	5
126	6x43	6x46	adenosine_off	0	0	No	Yes	No	No	6	6
127	4x47	4x51	adenosine_off	0	0	No	No	No	No	4	4
128	4x51	4x55	adenosine_off	0	0	No	No	No	No	4	4
129	1x41	1x45	adenosine_off	0	0	No	No	No	No	5	4
130	5x72	I3	adenosine_off	5	0	No	No	No	No	0	4
131	5x72	6x24	adenosine_off	5	0	No	No	Yes	No	0	2
132	8x61	8x64	adenosine_off	5	0	No	No	No	No	6	5
133	6x23	6x26	adenosine_off	5	0	No	No	No	No	4	3
134	1x27	1x30	adenosine_off	5	0	No	No	No	No	0	5
135	8x64	8x65	adenosine_off	0	0	No	No	No	No	5	0
136	5x70	5x73	adenosine_off	0	0	No	No	No	No	0	0
137	1x27	1x28	adenosine_off	0	0	No	No	No	No	0	0
138	5x73	6x24	adenosine_off	0	0	No	No	Yes	No	0	2
139	1x32	2x64	Shared	100	100	No	Yes	No	No	4	3
140	1x35	1x39	Shared	100	100	Yes	Yes	Yes	Yes	5	6
141	1x35	2x64	Shared	100	100	Yes	Yes	No	No	5	3
142	1x35	7x35	Shared	100	100	Yes	Yes	Yes	Yes	5	3
143	1x35	7x39	Shared	100	100	Yes	Yes	No	Yes	5	5
144	1x36	2x61	Shared	100	100	No	No	No	No	5	6
145	1x38	7x39	Shared	100	100	No	No	No	Yes	5	5
146	1x39	2x57	Shared	100	100	Yes	Yes	Yes	Yes	6	6
147	1x39	2x61	Shared	100	100	Yes	Yes	No	No	6	6
148	1x39	7x42	Shared	100	100	Yes	Yes	Yes	Yes	6	7
149	1x43	2x57	Shared	100	100	No	No	Yes	Yes	5	6
150	1x45	7x47	Shared	100	50	No	No	No	No	4	6
151	1x50	2x50	Shared	100	100	Yes	No	Yes	Yes	9	9
152	1x50	7x50	Shared	100	100	Yes	No	No	No	9	9
153	1x51	2x51	Shared	100	25	No	No	No	No	5	7
154	1x52	8x54	Shared	100	100	No	No	Yes	No	7	7
155	1x55	1x59	Shared	100	50	Yes	No	No	No	4	5
156	1x57	2x44	Shared	100	100	No	No	No	No	8	5
157	1x60	I1x50	Shared	100	100	Yes	No	Yes	Yes	6	8
158	1x60	8x53	Shared	100	100	Yes	No	No	Yes	6	6
159	2x40	I1x50	Shared	100	100	Yes	Yes	Yes	Yes	8	8
160	8x49	I1x50	Shared	100	100	No	No	Yes	Yes	6	8
161	8x50	I1x50	Shared	100	100	Yes	Yes	Yes	Yes	9	8
162	2x37	2x40	Shared	100	100	No	No	Yes	Yes	7	8
163	2x39	3x49	Shared	100	100	No	No	Yes	No	8	9
164	2x40	2x43	Shared	100	6.25	Yes	Yes	No	No	8	8
165	2x40	8x50	Shared	100	100	Yes	Yes	Yes	Yes	8	9
166	2x42	3x45	Shared	100	25	Yes	Yes	No	No	8	7
167	2x42	4x46	Shared	100	75	Yes	Yes	No	No	8	8
168	2x45	4x46	Shared	100	100	No	No	No	No	9	8
169	2x46	2x50	Shared	100	100	No	Yes	Yes	Yes	9	9
170	2x46	7x49	Shared	100	100	No	Yes	Yes	Yes	9	9
171	2x50	3x39	Shared	100	100	Yes	Yes	No	No	9	9
172	2x50	7x46	Shared	100	100	Yes	Yes	No	No	9	9
173	2x50	7x49	Shared	100	100	Yes	Yes	Yes	Yes	9	9
174	2x52	3x35	Shared	100	100	No	No	No	No	6	7
175	2x53	2x56	Shared	100	100	No	No	No	No	8	6
176	2x53	7x46	Shared	100	100	No	No	No	No	8	9
177	2x57	2x58	Shared	100	100	Yes	Yes	No	No	6	8
178	2x57	7x42	Shared	100	100	Yes	Yes	Yes	Yes	6	7
179	2x59	3x28	Shared	100	100	No	No	No	No	5	6
180	2x59	3x31	Shared	100	100	No	No	No	No	5	4
181	E1x51	E2	Shared	100	6.25	No	No	Yes	Yes	4	3
182	3x21	E2	Shared	100	100	No	No	Yes	Yes	6	3
183	3x22	E2	Shared	100	100	No	No	Yes	Yes	3	3
184	3x25	E2	Shared	100	100	No	No	Yes	Yes	9	3
185	3x25	E2x50	Shared	100	100	No	No	No	No	9	9
186	3x26	E2	Shared	100	100	No	No	Yes	Yes	5	3
187	3x27	4x61	Shared	100	100	No	No	No	Yes	4	5
188	3x32	Lig	Shared	100	100	No	No	Yes	Yes	6	0
189	3x33	5x39	Shared	100	100	No	No	Yes	Yes	4	6
190	3x34	4x54	Shared	100	100	No	No	No	No	5	3
191	3x34	4x58	Shared	100	0	No	No	No	No	5	4
192	3x37	3x41	Shared	100	100	Yes	Yes	No	No	6	4
193	3x37	4x53	Shared	100	25	Yes	Yes	No	No	6	8
194	3x37	4x56	Shared	100	100	Yes	Yes	No	Yes	6	5
195	3x37	5x461	Shared	100	100	Yes	Yes	Yes	Yes	6	8
196	3x38	4x50	Shared	100	100	No	No	No	No	7	9
197	3x38	4x53	Shared	100	100	No	No	No	No	7	8
198	3x40	5x50	Shared	100	87.5	No	Yes	No	No	8	8
199	3x40	6x44	Shared	100	100	No	Yes	Yes	Yes	8	9
200	3x41	4x49	Shared	100	100	No	No	No	No	4	7
201	3x43	6x44	Shared	100	100	No	Yes	Yes	Yes	8	9
202	3x47	5x57	Shared	100	50	No	No	No	No	9	6
203	3x47	5x58	Shared	100	100	No	No	No	Yes	9	9
204	3x49	I2x53	Shared	100	100	Yes	No	Yes	Yes	9	7
205	3x51	3x55	Shared	100	100	No	No	No	No	7	7
206	3x51	5x60	Shared	100	100	No	No	No	No	7	4
207	3x53	I2x53	Shared	100	100	Yes	No	Yes	Yes	8	7
208	3x54	5x61	Shared	100	50	Yes	No	No	No	9	9
209	3x56	I2x52	Shared	100	100	No	No	Yes	No	6	5
210	I2x53	I2x57	Shared	100	100	Yes	Yes	No	No	7	7
211	4x38	4x41	Shared	100	100	No	No	No	No	8	5
212	4x56	5x461	Shared	100	100	No	Yes	Yes	Yes	5	8
213	4x59	4x60	Shared	100	100	No	No	No	No	6	4
214	4x59	5x39	Shared	100	100	No	No	Yes	Yes	6	6
215	4x60	5x39	Shared	100	100	No	No	Yes	Yes	4	6
216	5x36	E2	Shared	100	100	No	No	Yes	Yes	5	3
217	5x39	E2	Shared	100	100	Yes	Yes	Yes	Yes	6	3
218	5x42	E2	Shared	100	100	No	Yes	Yes	Yes	5	3
219	E2	E2	Shared	100	100	Yes	Yes	Yes	Yes	3	3
220	E2	E2x51	Shared	100	100	Yes	Yes	No	No	3	4
221	E2	E2x52	Shared	100	100	Yes	Yes	No	Yes	3	4
222	E2x52	Lig	Shared	100	100	No	Yes	Yes	Yes	4	0
223	E2	Lig	Shared	100	100	Yes	Yes	Yes	Yes	3	0
224	5x36	5x38	Shared	100	100	No	No	No	No	5	3
225	5x37	6x55	Shared	100	100	No	No	No	No	3	5
226	5x37	6x59	Shared	100	31.25	No	No	Yes	No	3	4
227	5x39	5x40	Shared	100	100	Yes	Yes	Yes	Yes	6	5
228	5x39	5x42	Shared	100	100	Yes	Yes	No	Yes	6	5
229	5x39	5x43	Shared	100	100	Yes	Yes	No	No	6	5
230	5x40	5x43	Shared	100	100	Yes	Yes	No	No	5	5
231	5x40	6x55	Shared	100	100	Yes	Yes	No	No	5	5
232	5x40	Lig	Shared	100	100	Yes	Yes	Yes	Yes	5	0
233	5x41	6x59	Shared	100	100	No	No	Yes	No	4	4
234	5x411	6x59	Shared	100	100	No	No	Yes	No	4	4
235	5x411	6x60	Shared	100	100	No	No	No	No	4	4
236	5x42	5x461	Shared	100	100	No	Yes	Yes	Yes	5	8
237	5x44	5x45	Shared	100	100	Yes	Yes	No	No	5	4
238	5x44	5x47	Shared	100	100	Yes	Yes	No	No	5	5
239	5x44	5x48	Shared	100	100	Yes	Yes	No	No	5	5
240	5x44	6x52	Shared	100	100	Yes	Yes	No	No	5	7
241	5x46	5x461	Shared	100	100	No	No	Yes	Yes	5	8
242	5x47	6x52	Shared	100	100	No	No	No	No	5	7
243	5x49	5x50	Shared	100	100	No	No	No	No	4	8
244	5x58	6x37	Shared	100	100	No	Yes	No	No	9	8
245	5x62	6x34	Shared	100	100	No	No	No	No	6	7
246	6x36	7x56	Shared	100	100	No	No	Yes	No	8	7
247	6x39	7x56	Shared	100	50	No	No	Yes	No	6	7
248	6x44	6x48	Shared	100	100	Yes	Yes	Yes	Yes	9	8
249	6x47	7x45	Shared	100	100	No	No	Yes	No	8	9
250	6x48	7x41	Shared	100	100	Yes	Yes	No	No	8	7
251	6x48	7x45	Shared	100	100	Yes	Yes	Yes	No	8	9
252	6x48	Lig	Shared	100	100	Yes	Yes	Yes	Yes	8	0
253	6x51	Lig	Shared	100	100	No	No	Yes	Yes	6	0
254	6x55	Lig	Shared	100	100	No	No	Yes	Yes	5	0
255	6x61	E3	Shared	100	100	No	No	Yes	Yes	4	3
256	7x30	7x33	Shared	100	100	No	No	No	No	4	4
257	7x31	7x35	Shared	100	100	No	No	Yes	Yes	3	3
258	7x34	Lig	Shared	100	50	No	No	Yes	Yes	4	0
259	7x38	7x42	Shared	100	100	No	No	Yes	Yes	5	7
260	7x38	Lig	Shared	100	100	No	No	Yes	Yes	5	0
261	8x47	8x50	Shared	100	100	No	No	Yes	Yes	8	9
262	3x33	5x43	Shared	100	100	No	No	No	No	4	5
263	4x38	4x40	Shared	100	0	No	No	No	No	8	5
264	6x58	E3	Shared	100	100	No	No	Yes	Yes	4	3
265	8x49	I1x49	Shared	100	100	No	No	No	No	6	6
266	8x48	8x52	Shared	100	0	No	No	No	No	4	4
267	3x29	E2	Shared	65	75	No	No	Yes	Yes	4	3
268	8x60	8x61	Shared	75	50	No	No	No	No	6	6
269	4x38	4x39	Shared	55	100	No	No	No	No	8	3
270	I2x52	I2x56	Shared	60	25	Yes	No	No	No	5	4
271	6x43	7x48	Shared	20	100	No	Yes	No	No	6	6
272	1x46	7x46	Shared	50	100	No	No	No	No	8	9
273	3x54	5x65	Shared	50	0	Yes	No	No	No	9	8
274	6x39	6x43	Shared	50	100	No	No	No	Yes	6	6
275	8x51	8x55	Shared	50	0	No	No	No	No	8	5
276	6x51	7x37	Shared	45	37.5	No	No	No	No	6	5
277	6x42	6x46	Shared	50	100	No	No	No	No	5	6
278	1x50	2x51	Shared	5	50	Yes	No	No	No	9	7
279	6x24	6x28	Shared	50	25	Yes	No	No	No	2	3
280	1x42	7x43	Shared	30	31.25	No	No	No	No	7	5
281	1x54	2x47	Shared	50	50	No	No	No	No	7	9
282	I1x48	I1x51	Shared	45	25	No	No	No	No	6	7
283	2x45	3x42	Shared	50	50	No	No	No	No	9	8
284	2x66	E1x50	Shared	55	50	No	No	Yes	No	3	3
285	6x57	E3	Shared	55	25	No	No	Yes	Yes	4	3
286	6x50	7x40	Shared	50	0	No	No	No	No	9	7
287	8x48	8x51	Shared	50	100	No	No	No	No	4	8
288	I2x53	I2x54	Shared	50	100	Yes	Yes	No	No	7	4
289	1x47	1x48	Shared	50	50	No	No	No	No	6	4
290	2x60	7x42	Shared	25	100	No	No	Yes	Yes	7	7
291	6x53	6x57	Shared	25	0	No	No	No	No	6	4
292	7x30	E3	Shared	25	50	No	No	Yes	Yes	4	3
293	2x42	4x45	Shared	50	100	Yes	Yes	No	No	8	5
294	8x56	8x60	Shared	35	6.25	No	No	No	No	5	6
295	1x46	7x47	Shared	25	56.25	No	No	No	No	8	6
296	3x34	4x57	Shared	5	100	No	No	No	No	5	6
297	3x54	5x64	Shared	25	100	Yes	No	No	No	9	5
298	5x55	5x59	Shared	30	6.25	No	No	No	No	5	3
299	1x54	2x48	Shared	50	0	No	No	No	No	7	6
300	2x65	E1x50	Shared	35	50	No	No	Yes	No	4	3
301	3x56	I2x50	Shared	0	0	No	No	No	No	6	8
302	1x37	1x40	Shared	25	0	No	No	No	No	5	4
303	4x63	E2	Shared	10	50	No	No	Yes	Yes	5	3
304	7x51	7x55	Shared	5	50	No	No	No	No	7	6
305	4x48	4x51	Shared	25	50	No	No	No	No	1	4
306	3x44	5x53	Shared	0	100	No	No	No	No	7	6
307	5x48	5x52	Shared	15	6.25	No	No	No	No	5	3
308	4x48	4x52	Shared	0	6.25	No	No	No	No	1	4
309	7x32	7x36	Shared	0	75	No	No	No	No	1	3
310	1x34	1x38	Shared	0	50	No	No	No	No	4	5
311	1x30	1x31	Shared	0	0	No	No	No	No	5	4
312	4x43	4x44	Shared	0	0	No	No	No	No	1	3
313	5x68	5x71	Shared	0	100	No	No	No	No	7	0
314	1x29	1x32	adenosine_on	0	100	No	No	No	Yes	6	4
315	1x31	7x32	adenosine_on	0	100	No	No	No	No	4	1
316	1x32	7x35	adenosine_on	0	100	No	Yes	Yes	Yes	4	3
317	1x35	7x38	adenosine_on	0	100	Yes	Yes	No	No	5	5
318	1x53	8x50	adenosine_on	0	100	No	No	Yes	Yes	9	9
319	1x54	2x44	adenosine_on	0	100	No	No	No	No	7	5
320	1x57	2x40	adenosine_on	0	100	No	No	Yes	Yes	8	8
321	8x53	I1x50	adenosine_on	0	100	No	Yes	Yes	Yes	6	8
322	2x37	2x39	adenosine_on	0	100	No	No	No	No	7	8
323	2x39	3x53	adenosine_on	0	100	No	No	Yes	No	8	8
324	2x40	8x47	adenosine_on	0	100	Yes	Yes	No	No	8	8
325	2x42	3x49	adenosine_on	0	100	Yes	Yes	Yes	No	8	9
326	2x46	3x42	adenosine_on	0	100	No	Yes	No	No	9	8
327	2x46	3x43	adenosine_on	0	100	No	Yes	No	Yes	9	8
328	2x551	3x35	adenosine_on	0	100	No	No	No	No	5	7
329	2x56	3x35	adenosine_on	0	100	No	No	No	No	6	7
330	2x62	3x28	adenosine_on	0	100	No	No	No	No	4	6
331	2x64	7x35	adenosine_on	0	100	No	No	Yes	Yes	3	3
332	E1x50	E1x52	adenosine_on	0	100	Yes	No	No	No	3	7
333	3x30	4x61	adenosine_on	0	100	No	No	No	Yes	6	5
334	3x33	E2x52	adenosine_on	0	100	No	No	No	Yes	4	4
335	3x36	Lig	adenosine_on	0	100	No	No	Yes	Yes	6	0
336	3x40	6x48	adenosine_on	0	100	No	Yes	Yes	Yes	8	8
337	3x43	7x49	adenosine_on	0	100	No	Yes	Yes	Yes	8	9
338	3x43	7x53	adenosine_on	0	100	No	Yes	Yes	Yes	8	9
339	3x46	3x50	adenosine_on	0	100	No	No	Yes	No	9	9
340	3x46	7x53	adenosine_on	0	100	No	No	Yes	Yes	9	9
341	3x50	5x58	adenosine_on	0	100	Yes	No	No	Yes	9	9
342	3x50	7x53	adenosine_on	0	100	Yes	No	Yes	Yes	9	9
343	3x51	5x57	adenosine_on	0	100	No	No	No	No	7	6
344	3x52	3x56	adenosine_on	0	100	No	No	No	No	5	6
345	4x52	5x461	adenosine_on	0	100	No	No	Yes	Yes	4	8
346	4x56	5x42	adenosine_on	0	100	No	Yes	No	Yes	5	5
347	4x59	E2	adenosine_on	0	100	No	No	Yes	Yes	6	3
348	4x60	E2	adenosine_on	0	100	No	No	Yes	Yes	4	3
349	5x51	6x44	adenosine_on	0	100	No	No	Yes	Yes	6	9
350	5x51	6x49	adenosine_on	0	100	No	No	No	No	6	7
351	5x54	5x58	adenosine_on	0	100	No	No	No	Yes	8	9
352	5x54	6x44	adenosine_on	0	100	No	No	Yes	Yes	8	9
353	5x55	6x41	adenosine_on	0	100	No	No	No	No	5	8
354	5x58	6x40	adenosine_on	0	100	No	Yes	No	No	9	8
355	5x58	6x41	adenosine_on	0	100	No	Yes	No	No	9	8
356	5x62	6x30	adenosine_on	0	100	No	No	Yes	Yes	6	6
357	5x63	5x66	adenosine_on	0	100	No	No	No	No	4	5
358	5x66	5x70	adenosine_on	0	100	No	No	No	No	5	0
359	6x25	6x26	adenosine_on	0	100	No	No	No	No	3	3
360	6x27	6x31	adenosine_on	0	100	No	No	No	No	1	5
361	6x29	6x32	adenosine_on	0	100	No	No	No	No	6	7
362	6x40	7x53	adenosine_on	0	100	No	No	Yes	Yes	8	9
363	6x51	7x41	adenosine_on	0	100	No	No	No	No	6	7
364	E3	E3	adenosine_on	0	100	Yes	Yes	Yes	Yes	3	3
365	7x34	E3	adenosine_on	0	100	No	No	Yes	Yes	4	3
366	7x36	7x39	adenosine_on	0	100	No	No	No	Yes	3	5
367	7x42	Lig	adenosine_on	0	100	Yes	Yes	Yes	Yes	7	0
368	7x45	7x49	adenosine_on	0	100	Yes	No	Yes	Yes	9	9
369	7x52	7x53	adenosine_on	0	100	No	No	Yes	Yes	8	9
370	7x54	8x50	adenosine_on	0	100	No	No	Yes	Yes	7	9
371	7x55	8x51	adenosine_on	0	100	No	No	No	No	6	8
372	5x69	6x29	adenosine_on	0	100	No	No	No	No	4	6
373	2x53	2x54	adenosine_on	0	75	No	No	No	No	8	7
374	3x44	5x50	adenosine_on	0	75	No	No	No	No	7	8
375	6x54	E3	adenosine_on	0	56.25	No	No	Yes	Yes	4	3
376	3x26	4x61	adenosine_on	0	50	No	No	No	Yes	5	5
377	2x55	2x551	adenosine_on	0	50	No	No	No	No	4	5
378	3x40	5x47	adenosine_on	0	50	No	Yes	No	No	8	5
379	2x42	4x42	adenosine_on	0	25	Yes	Yes	No	No	8	7
380	1x42	7x39	adenosine_on	0	75	No	No	No	Yes	7	5
381	2x63	3x28	adenosine_on	0	50	No	No	No	No	3	6
382	5x61	6x37	adenosine_on	0	50	No	No	No	No	9	8
383	2x49	3x38	adenosine_on	0	56.25	No	No	No	No	8	7
384	5x65	6x33	adenosine_on	0	50	No	No	No	No	8	7
385	3x23	3x27	adenosine_on	0	50	No	No	No	No	1	4
386	8x52	8x53	adenosine_on	0	50	No	No	No	Yes	4	6
387	2x63	E2x52	adenosine_on	0	6.25	No	No	No	Yes	3	4
388	4x50	4x54	adenosine_on	0	6.25	No	No	No	No	9	3
389	2x41	4x42	adenosine_on	0	56.25	No	No	No	No	4	7
390	3x48	5x57	adenosine_on	0	0	No	No	No	No	6	6
391	3x21	3x24	adenosine_on	0	25	No	No	No	No	6	5
392	6x56	6x60	adenosine_on	0	25	No	No	No	No	5	4
393	1x56	8x50	adenosine_on	0	6.25	No	No	Yes	Yes	8	9
394	7x55	8x54	adenosine_on	0	25	No	No	Yes	No	6	7
395	6x27	6x30	adenosine_on	0	12.5	No	No	Yes	Yes	1	6
396	1x47	2x51	adenosine_on	0	50	No	No	No	No	6	7
397	2x66	E2	adenosine_on	0	50	No	No	Yes	Yes	3	3
398	5x66	6x30	adenosine_on	0	50	No	No	Yes	Yes	5	6
399	I2x55	I2x56	adenosine_on	0	6.25	No	No	No	No	5	4
400	3x52	I2x53	adenosine_on	0	0	No	No	Yes	Yes	5	7
401	2x38	I2x57	adenosine_on	0	6.25	No	No	No	No	6	7
402	7x39	7x40	adenosine_on	0	50	No	Yes	No	No	5	7
403	1x48	1x49	adenosine_on	0	0	No	No	No	No	4	8
404	1x36	1x40	adenosine_on	0	12.5	No	No	No	No	5	4
405	6x31	6x35	adenosine_on	0	0	No	No	No	No	5	7
406	6x49	6x50	adenosine_on	0	0	No	No	No	No	7	9
407	6x45	6x49	adenosine_on	0	0	No	No	No	No	6	7
408	6x43	7x52	adenosine_on	0	0	No	Yes	No	No	6	8
409	5x61	5x65	adenosine_on	0	0	No	No	No	No	9	8
410	5x62	6x37	adenosine_on	0	6.25	No	No	No	No	6	8
411	5x69	6x30	adenosine_on	0	6.25	No	No	Yes	Yes	4	6
412	5x64	5x67	adenosine_on	0	0	No	No	No	No	5	4
413	1x32	NT	adenosine_on	0	0	No	Yes	No	No	4	0
414	1x33	7x35	adenosine_on	0	25	No	No	Yes	Yes	5	3
415	5x73	6x26	adenosine_on	0	25	No	No	No	No	0	3
416	6x42	6x43	adenosine_on	0	0	No	No	No	Yes	5	6
417	1x55	1x58	adenosine_on	0	0	Yes	No	No	No	4	3
418	1x52	1x55	adenosine_on	0	0	No	No	Yes	No	7	4
419	4x40	4x43	adenosine_on	0	25	No	No	No	No	5	1
420	1x57	I1x51	adenosine_on	0	0	No	No	No	No	8	7
421	4x39	4x42	adenosine_on	0	0	No	No	No	No	3	7
422	6x25	6x28	adenosine_on	0	25	No	No	No	No	3	3
423	5x70	6x26	adenosine_on	0	6.25	No	No	No	No	0	3
424	4x55	4x56	adenosine_on	0	0	No	No	No	Yes	4	5
425	1x40	1x44	adenosine_on	0	0	No	No	No	No	4	5
426	1x38	1x41	adenosine_on	0	0	No	No	No	No	5	5
427	1x41	1x42	adenosine_on	0	0	No	No	No	No	5	7
428	8x53	8x57	adenosine_on	0	12.5	No	Yes	No	No	6	7
429	4x44	4x47	adenosine_on	0	0	No	No	No	No	3	4
430	8x52	8x56	adenosine_on	0	6.25	No	No	No	No	4	5
431	5x73	I3	adenosine_on	0	12.5	No	No	No	No	0	4
432	5x56	5x60	adenosine_on	0	6.25	No	No	No	No	4	4
433	5x67	5x71	adenosine_on	0	6.25	No	No	No	No	4	0
434	5x69	5x72	adenosine_on	0	6.25	No	No	No	No	4	0
435	1x27	2x65	adenosine_on	0	6.25	No	No	No	No	0	4
436	4x61	4x62	adenosine_on	0	6.25	No	Yes	No	No	5	4
437	8x55	8x58	adenosine_on	0	0	No	No	No	No	5	5
438	1x28	1x33	adenosine_on	0	0	No	No	No	No	0	5

Orange: nodes, hubs and links specific of adenosine_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of adenosine_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	adenosine_off Avg Int. Strength	adenosine_on Avg Int. Strength	adenosine_off Num Of Links	adenosine_on Num Of Links	ConSurf
1	1x50	adenosine_off	0	37.5	4	3	9
2	1x55	adenosine_off	0	0	4	3	4
3	1x60	adenosine_off	50	0	4	2	6
4	E1x50	adenosine_off	0	0	4	3	3
5	3x49	adenosine_off	35	0	5	3	9
6	3x50	adenosine_off	85	0	5	3	9
7	3x53	adenosine_off	50	0	4	2	8
8	3x54	adenosine_off	0	0	5	3	9
9	I2x52	adenosine_off	0	0	4	2	5
10	6x24	adenosine_off	0	0	5	1	2
11	6x59	adenosine_off	65	0	4	3	4
12	7x45	adenosine_off	25	0	4	3	9
13	7x56	adenosine_off	10	0	5	2	7
14	8x54	adenosine_off	0	0	4	2	7
15	1x35	Shared	25	93.75	5	5	5
16	1x39	Shared	50	93.75	5	4	6
17	I1x50	Shared	35	43.75	5	5	8
18	2x40	Shared	20	75	4	6	8
19	2x42	Shared	10	0	4	5	8
20	2x50	Shared	40	100	5	5	9
21	2x57	Shared	90	100	6	4	6
22	3x37	Shared	100	0	5	4	6
23	I2x53	Shared	35	50	4	5	7
24	E2	Shared	100	100	18	18	3
25	5x39	Shared	100	100	7	7	6
26	5x40	Shared	80	43.75	6	4	5
27	5x44	Shared	75	75	5	4	5
28	5x461	Shared	50	50	4	5	8
29	6x30	Shared	0	0	4	4	6
30	6x44	Shared	100	37.5	5	5	9
31	6x48	Shared	70	100	5	5	8
32	E3	Shared	45	68.75	6	8	3
33	7x35	Shared	0	50	4	5	3
34	7x42	Shared	80	93.75	5	5	7
35	7x49	Shared	40	93.75	4	4	9
36	7x53	Shared	70	93.75	5	5	9
37	8x50	Shared	70	43.75	6	6	9
38	Lig	Shared	100	100	13	11	0
39	1x32	adenosine_on	0	0	1	4	4
40	2x46	adenosine_on	0	0	3	4	9
41	3x40	adenosine_on	0	50	3	4	8
42	3x43	adenosine_on	0	31.25	2	4	8
43	4x56	adenosine_on	0	6.25	2	4	5
44	4x61	adenosine_on	0	0	2	4	5
45	E2x52	adenosine_on	0	0	3	4	4
46	5x42	adenosine_on	0	75	3	4	5
47	5x58	adenosine_on	0	100	3	6	9
48	6x43	adenosine_on	0	0	3	4	6
49	7x39	adenosine_on	0	50	3	5	5
50	8x53	adenosine_on	0	0	2	4	6

Orange: nodes, hubs and links specific of adenosine_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of adenosine_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	adenosine_off Recurrence	adenosine_on Recurrence	adenosine_off Hub1?	adenosine_on Hub1?	adenosine_off Hub2?	adenosine_on Hub2?	ConSurf1	ConSurf2
1	1x35	Lig	adenosine_off	12.0563	0	Yes	Yes	Yes	Yes	5	0
2	3x39	6x44	adenosine_off	100	0	No	No	Yes	Yes	9	9
3	2x50	3x39	adenosine_off	53.0467	1.90903	Yes	Yes	No	No	9	9
4	2x46	3x39	adenosine_off	47.2098	0	No	Yes	No	No	9	9
5	7x49	7x53	adenosine_off	99.8594	0	Yes	Yes	Yes	Yes	9	9
6	7x53	8x50	adenosine_off	59.8453	0	Yes	Yes	Yes	Yes	9	9
7	8x50	8x54	adenosine_off	11.5848	0	Yes	Yes	Yes	No	9	7
8	2x43	7x53	adenosine_off	40.4588	0	No	No	Yes	Yes	8	9
9	2x40	2x43	adenosine_off	39.7783	1.8613	Yes	Yes	No	No	8	8
10	2x40	8x50	adenosine_off	41.102	6.34752	Yes	Yes	Yes	Yes	8	9
11	2x37	3x53	adenosine_off	78.7189	0	No	No	Yes	No	7	8
12	3x53	I2x53	adenosine_off	12.1949	3.04343	Yes	No	Yes	Yes	8	7
13	2x45	4x50	adenosine_off	17.6905	0	No	No	No	No	9	9
14	3x40	6x44	adenosine_off	28.9195	6.78072	No	Yes	Yes	Yes	8	9
15	3x37	3x40	adenosine_off	26.605	0	Yes	Yes	No	Yes	6	8
16	3x53	6x30	adenosine_off	55.9113	0	Yes	No	Yes	Yes	8	6
17	3x54	6x30	adenosine_off	50.3682	0	Yes	No	Yes	Yes	9	6
18	3x54	5x61	adenosine_off	27.6227	9.55248	Yes	No	No	No	9	9
19	3x51	5x61	adenosine_off	26.2058	0	No	No	No	No	7	9
20	3x51	3x55	adenosine_off	19.2314	1.97878	No	No	No	No	7	7
21	3x55	3x56	adenosine_off	17.4775	0	No	No	No	No	7	6
22	3x56	I2x52	adenosine_off	13.9571	5.86659	No	No	Yes	No	6	5
23	6x52	Lig	adenosine_off	14.1412	0	No	No	Yes	Yes	7	0
24	5x44	6x52	adenosine_off	10.139	0.0110136	Yes	Yes	No	No	5	7
25	7x45	7x48	adenosine_off	17.6926	0	Yes	No	No	No	9	6
26	6x43	7x48	adenosine_off	16.7515	1.30328	No	Yes	No	No	6	6
27	6x39	6x43	adenosine_off	13.9034	3.7226	No	No	No	Yes	6	6
28	6x39	7x56	adenosine_off	12.9333	2.42667	No	No	Yes	No	6	7
29	3x54	5x68	adenosine_off	17.3409	0	Yes	No	No	No	9	7
30	5x68	6x27	adenosine_off	14.4473	0	No	No	No	No	7	1
31	5x69	6x27	adenosine_off	12.6934	0	No	No	No	No	4	1
32	7x41	7x42	adenosine_off	12.2301	0	No	No	Yes	Yes	7	7
33	6x48	7x41	adenosine_off	13.1195	2.94431	Yes	Yes	No	No	8	7
34	5x69	6x24	adenosine_off	10.927	0	No	No	Yes	No	4	2
35	6x44	7x45	adenosine_off	15.8042	0	Yes	Yes	Yes	No	9	9
36	6x48	Lig	Shared	57.9714	97.3788	Yes	Yes	Yes	Yes	8	0
37	6x44	6x48	Shared	66.0875	55.2663	Yes	Yes	Yes	Yes	9	8
38	2x46	7x49	Shared	47.1229	29.9607	No	Yes	Yes	Yes	9	9
39	2x50	7x49	Shared	54.3435	21.1425	Yes	Yes	Yes	Yes	9	9
40	2x37	2x40	Shared	80.3487	57.2782	No	No	Yes	Yes	7	8
41	E2	Lig	Shared	22.8655	56.5256	Yes	Yes	Yes	Yes	3	0
42	3x37	4x53	Shared	21.8023	19.7915	Yes	Yes	No	No	6	8
43	3x38	4x53	Shared	20.7806	17.3428	No	No	No	No	7	8
44	3x38	4x50	Shared	19.7547	12.4234	No	No	No	No	7	9
45	2x45	4x46	Shared	15.6097	97.2686	No	No	No	No	9	8
46	1x35	7x39	adenosine_on	2.92877	14.6995	Yes	Yes	No	Yes	5	5
47	1x35	7x38	adenosine_on	0	25.838	Yes	Yes	No	No	5	5
48	7x38	Lig	adenosine_on	3.23281	26.6897	No	No	Yes	Yes	5	0
49	6x48	7x45	adenosine_on	5.60933	41.1469	Yes	Yes	Yes	No	8	9
50	7x45	7x49	adenosine_on	0	40.5301	Yes	No	Yes	Yes	9	9
51	2x50	7x46	adenosine_on	8.52983	20.6322	Yes	Yes	No	No	9	9
52	1x50	2x50	adenosine_on	5.38802	13.231	Yes	No	Yes	Yes	9	9
53	3x43	6x44	adenosine_on	5.88028	61.0118	No	Yes	Yes	Yes	8	9
54	2x46	3x43	adenosine_on	0	77.4111	No	Yes	No	Yes	9	8
55	2x46	3x42	adenosine_on	0	100	No	Yes	No	No	9	8
56	2x45	3x42	adenosine_on	1.10242	98.638	No	No	No	No	9	8
57	2x42	4x46	adenosine_on	9.26822	95.8919	Yes	Yes	No	No	8	8
58	2x42	3x49	adenosine_on	0	78.7107	Yes	Yes	Yes	No	8	9
59	2x39	3x49	adenosine_on	0.00827335	60.674	No	No	Yes	No	8	9
60	2x37	2x39	adenosine_on	0	58.8862	No	No	No	No	7	8
61	2x40	I1x50	adenosine_on	1.01142	34.7149	Yes	Yes	Yes	Yes	8	8
62	8x53	I1x50	adenosine_on	0	28.0664	No	Yes	Yes	Yes	6	8
63	8x52	8x53	adenosine_on	0	25.3534	No	No	No	Yes	4	6
64	8x48	8x52	adenosine_on	0.891454	18.9912	No	No	No	No	4	4
65	8x48	8x51	adenosine_on	2.61852	17.1959	No	No	No	No	4	8
66	7x55	8x51	adenosine_on	0	12.5372	No	No	No	No	6	8
67	1x57	2x40	adenosine_on	0	12.8969	No	No	Yes	Yes	8	8
68	3x49	I2x53	adenosine_on	5.115	19.5602	Yes	No	Yes	Yes	9	7
69	2x53	7x46	adenosine_on	7.48531	13.231	No	No	No	No	8	9
70	5x42	E2	adenosine_on	6.45115	34.6305	No	Yes	Yes	Yes	5	3
71	4x56	5x42	adenosine_on	0	15.8413	No	Yes	No	Yes	5	5
72	3x37	4x56	adenosine_on	0.781832	13.4843	Yes	Yes	No	Yes	6	5
73	5x42	5x461	adenosine_on	7.51013	19.3509	No	Yes	Yes	Yes	5	8
74	3x37	5x461	adenosine_on	8.12443	13.6055	Yes	Yes	Yes	Yes	6	8
75	3x43	7x53	adenosine_on	0	41.3965	No	Yes	Yes	Yes	8	9
76	5x54	6x44	adenosine_on	0	38.1512	No	No	Yes	Yes	8	9
77	5x54	5x58	adenosine_on	0	37.3692	No	No	No	Yes	8	9
78	3x47	5x58	adenosine_on	2.20278	13.7193	No	No	No	Yes	9	9
79	3x47	5x57	adenosine_on	1.10242	11.7809	No	No	No	No	9	6
80	3x52	I2x53	adenosine_on	0	11.6708	No	No	Yes	Yes	5	7
81	5x58	6x37	adenosine_on	4.12013	50.2001	No	Yes	No	No	9	8
82	5x61	6x37	adenosine_on	0	15.129	No	No	No	No	9	8
83	2x42	4x42	adenosine_on	0	16.1717	Yes	Yes	No	No	8	7
84	4x39	4x42	adenosine_on	0	12.6657	No	No	No	No	3	7
85	4x38	4x39	adenosine_on	1.79325	10.8778	No	No	No	No	8	3
86	6x40	7x53	adenosine_on	0	17.3685	No	No	Yes	Yes	8	9
87	5x58	6x40	adenosine_on	0	17.0785	No	Yes	No	No	9	8
88	5x62	6x37	adenosine_on	0	34.5167	No	No	No	No	6	8
89	5x62	6x30	adenosine_on	0	31.0731	No	No	Yes	Yes	6	6
90	5x66	6x30	adenosine_on	0	16.748	No	No	Yes	Yes	5	6
91	5x66	5x70	adenosine_on	0	12.9006	No	No	No	No	5	0
92	5x70	6x26	adenosine_on	0	10.9512	No	No	No	No	0	3
93	7x52	7x53	adenosine_on	0	10.0261	No	No	Yes	Yes	8	9
94	7x34	Lig	adenosine_on	1.59676	10.1619	No	No	Yes	Yes	4	0
95	3x50	7x53	adenosine_on	0	17.1959	Yes	No	Yes	Yes	9	9
96	3x50	5x58	adenosine_on	0	16.983	Yes	No	No	Yes	9	9
97	7x42	Lig	adenosine_on	0	12.3646	Yes	Yes	Yes	Yes	7	0
98	2x46	2x50	adenosine_on	0.0579135	15.7091	No	Yes	Yes	Yes	9	9
99	3x43	7x49	adenosine_on	0	11.5019	No	Yes	Yes	Yes	8	9

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
1x32	2x64	Shared	5.28	3.96	0	1	2	2
1x35	1x39	Shared	15.0385	22.6587	1	1	1	2
1x35	2x64	Shared	7.3955	5.87625	1	1	1	2
1x35	7x35	Shared	10.3775	10.0888	1	1	1	1
1x35	7x39	Shared	3.1965	3.28625	1	1	1	2
1x35	Lig	adenosine_off	3.4385	0	1	1	1	0
1x39	2x57	Shared	8.1975	6.23625	1	1	2	2
1x39	7x39	adenosine_off	3.881	0	1	1	2	2
1x39	7x42	Shared	11.449	10.3856	1	1	2	1
2x56	3x32	adenosine_off	4.0155	0	0	0	2	1
2x57	7x42	Shared	6.8935	7.0425	1	1	2	1
E1x51	E2	Shared	9.05	0.404375	0	0	2	1
3x21	3x23	adenosine_off	4.0825	0	1	1	2	2
3x21	E2	Shared	6.03	3.93	1	1	2	1
3x22	E2	Shared	24.75	18.6737	0	0	2	1
3x23	E2	adenosine_off	7.5035	0	1	0	2	1
3x25	E2	Shared	7.1375	4.69625	1	1	2	1
3x26	E2	Shared	12.204	9.13562	0	1	2	1
3x32	Lig	Shared	4.4965	4.41687	0	0	1	0
3x33	5x39	Shared	5.0425	4.68937	1	1	2	2
3x33	5x40	adenosine_off	4.099	0	1	1	2	1
3x36	6x48	adenosine_off	9.3655	0	0	0	1	1
3x40	6x44	Shared	5.839	5.02313	0	1	2	2
4x59	4x60	Shared	3.6745	4.04688	1	1	2	2
4x59	5x39	Shared	6.1195	3.28062	1	1	2	2
4x60	5x39	Shared	14.5355	12.7806	1	1	2	2
5x36	E2	Shared	15.452	4.93625	1	1	2	1
5x39	E2	Shared	13.432	8.57875	1	1	2	1
5x42	E2	Shared	5.8645	4.635	1	1	2	1
E2	E2	Shared	68.6055	38.87	1	1	1	1
E2	E2x51	Shared	10.2145	7.8375	1	1	1	2
E2	E2x52	Shared	12.4085	12.47	1	1	1	1
5x40	E2x52	adenosine_off	4.0435	0	1	1	1	1
E2x52	Lig	Shared	36.3915	31.6469	1	1	1	0
E2	Lig	Shared	7.0195	7.45687	1	1	1	0
5x36	5x38	Shared	5.0755	5.2625	1	1	2	2
5x37	6x55	Shared	6.3795	4.55937	0	0	2	1
5x37	6x58	adenosine_off	3.4625	0	0	0	2	2
5x39	5x40	Shared	4.6075	3.96563	1	1	2	1
5x39	5x42	Shared	8.408	5.48313	1	1	2	2
5x39	5x43	Shared	5.755	3.19875	1	1	2	2
5x40	5x43	Shared	4.9065	6.04625	1	1	1	2
5x40	6x55	Shared	3.927	3.32875	1	1	1	1
5x40	Lig	Shared	4.343	3.92313	1	1	1	0
5x44	5x47	Shared	4.9805	4.42125	1	1	2	2
5x44	6x52	Shared	24.325	15.77	1	1	2	1
5x47	6x52	Shared	6.7125	10.2031	1	1	2	1
6x44	6x48	Shared	14.935	10.2712	1	1	2	1
6x44	7x45	adenosine_off	7.4915	0	1	1	2	2
6x48	7x41	Shared	11.8555	5.5775	1	1	1	2
6x48	7x45	Shared	3.842	9.11063	1	1	1	2
6x48	Lig	Shared	5.079	3.41375	1	1	1	0
6x51	Lig	Shared	16.7825	9.46812	0	0	1	0
6x54	7x34	adenosine_off	3.52	0	0	0	2	1
6x55	Lig	Shared	12.881	7.74	1	1	1	0
6x61	E3	Shared	11.5405	6.50375	0	0	2	1
7x31	7x35	Shared	5.307	4.89	0	0	2	1
7x34	Lig	Shared	4.2025	2.05813	0	1	1	0
7x35	Lig	adenosine_off	6.673	0	1	1	1	0
7x38	7x42	Shared	4.576	4.14563	0	1	1	1
7x38	Lig	Shared	10.975	8.20687	0	1	1	0
7x41	7x42	adenosine_off	3.5465	0	0	0	2	1
3x33	5x43	Shared	4.0525	3.51562	1	1	2	2
5x38	E2	adenosine_off	5.4605	0	1	0	2	1
6x52	Lig	adenosine_off	3.59	0	1	1	1	0
6x58	E3	Shared	7.2495	5.08063	0	0	2	1
E3	Lig	adenosine_off	3.303	0	1	1	1	0
E2	E3	adenosine_off	4.617	0	1	1	1	1
3x29	E2	Shared	3.155	2.82875	0	0	2	1
6x51	7x37	Shared	2.758	2.99875	0	0	1	2
6x57	E3	Shared	2.3065	2.2375	0	1	2	1
2x60	7x42	Shared	2.1975	3.38438	0	0	2	1
7x30	E3	Shared	2.1525	2.76688	1	1	2	1
4x63	E2	Shared	1.359	2.12	0	0	2	1
1x31	7x35	adenosine_off	1.105	0	0	0	2	1
1x32	7x35	adenosine_on	0	3.7175	0	1	2	1
1x35	7x38	adenosine_on	0	9.59562	1	1	1	1
2x64	7x35	adenosine_on	0	3.8075	0	1	2	1
3x33	E2x52	adenosine_on	0	3.27313	1	1	2	1
3x36	Lig	adenosine_on	0	10.9675	0	0	1	0
3x40	6x48	adenosine_on	0	16.8831	0	1	2	1
4x59	E2	adenosine_on	0	3.4875	1	1	2	1
4x60	E2	adenosine_on	0	3.34562	1	1	2	1
6x51	7x41	adenosine_on	0	5.34437	0	0	1	2
E3	E3	adenosine_on	0	3.14188	1	1	1	1
7x34	E3	adenosine_on	0	3.145	0	1	1	1
7x42	Lig	adenosine_on	0	6.5975	1	1	1	0
6x54	E3	adenosine_on	0	2.995	0	0	2	1
3x40	5x47	adenosine_on	0	2.8825	0	1	2	2
2x63	E2x52	adenosine_on	0	2.35375	0	0	2	1
2x66	E2	adenosine_on	0	2.07125	0	1	2	1
1x33	7x35	adenosine_on	0	1.335	0	0	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	adenosine_off	a1_off a2_off
	adenosine_on	a1_on a2_on

Network Difference
Value	adenosine_off	adenosine_on
I_min	3.1825	3.12812
Number of Linked Nodes	275	266
Number of Specific Nodes	10 (3.64%)	1 (0.38%)
Number of Shared Nodes	265 (96.36%)	265 (99.62%)
Number of Links	313	300
Number of Specific Links	138 (44.09%)	125 (41.67%)
Number of Shared Links	175 (55.91%)	175 (58.33%)
Number of Hubs	38	36
Number of Specific Hubs	14 (36.84%)	12 (33.33%)
Number of Shared Hubs	24 (63.16%)	24 (66.67%)
Average % Shared Neighbours (Jaccard)	43.54
Average % Shared Neighbours (Otsuka)	53.14
Average % Shared Neighbours (Overlap Coefficient)	62.49
Average % Shared Cliques (k3-6)	56.55
Graphlets Similarity	0.693638

Paths Difference
Value	adenosine_off	adenosine_on
Number Of Nodes in MetaPath	44	59
Specific Nodes in MetaPath	22 (50.00%)	37 (62.71%)
Shared Nodes in MetaPath	265 (96.36%)	265 (96.36%)
Number Of Links MetaPath	45	64
Specific Links in MetaPath	35 (77.78%)	54 (84.38%)
Shared Links in MetaPath	175 (55.91%)	175 (55.91%)
Number of Shortest Paths	75984	58679
Length Of Smallest Path	3	3
Average Path Length	14.6795	13.8767
Length of Longest Path	33	33
Minimum Path Strength	0.262333	0.445312
Average Path Strength	5.61616	5.4213
Maximum Path Strength	21.4355	20.5575
Minimum Path Correlation	0.7045	0.703125
Average Path Correlation	0.914885	0.922394
Maximum Path Correlation	0.99	0.989375
Minimum % Of Corr. Nodes	3.7037	3.44828
Average % Of Corr. Nodes	39.9387	44.5787
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	50.1663	44.8289
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

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