psnGPCR

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Orange: nodes, hubs and links specific of adenosine_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of adenosine_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	adenosine_off Int. Strength	adenosine_on Int. Strength	adenosine_off Hub1?	adenosine_on Hub1?	adenosine_off Hub2?	adenosine_on Hub2?	ConSurf1	ConSurf2
1	1x32	2x64	adenosine_off	100	0	No	No	No	No	4	3
2	1x49	7x50	adenosine_off	100	0	No	No	No	No	8	9
3	1x50	2x47	adenosine_off	100	0	Yes	No	No	No	9	9
4	1x51	2x51	adenosine_off	100	0	No	No	No	No	5	7
5	1x52	8x57	adenosine_off	100	0	No	No	No	No	7	7
6	1x53	7x50	adenosine_off	100	0	No	No	No	No	9	9
7	1x53	7x53	adenosine_off	100	0	No	No	Yes	Yes	9	9
8	1x55	8x57	adenosine_off	100	0	Yes	No	No	No	4	7
9	1x55	8x61	adenosine_off	100	0	Yes	No	No	No	4	6
10	1x60	8x49	adenosine_off	100	0	Yes	Yes	No	No	6	6
11	8x50	I1x50	adenosine_off	100	0	Yes	Yes	Yes	Yes	9	8
12	2x37	3x53	adenosine_off	100	0	No	No	Yes	No	7	8
13	2x38	3x49	adenosine_off	100	0	No	No	Yes	Yes	6	9
14	2x39	3x50	adenosine_off	100	0	No	No	Yes	No	8	9
15	2x42	3x46	adenosine_off	100	0	Yes	Yes	No	No	8	9
16	2x43	7x53	adenosine_off	100	0	No	No	Yes	Yes	8	9
17	2x53	3x35	adenosine_off	100	0	No	No	No	Yes	8	7
18	2x54	2x57	adenosine_off	100	0	No	No	Yes	Yes	7	6
19	2x551	2x59	adenosine_off	100	0	No	No	No	No	5	5
20	2x551	3x31	adenosine_off	100	0	No	No	Yes	No	5	4
21	2x63	E2x50	adenosine_off	100	0	No	No	No	No	3	9
22	3x21	3x23	adenosine_off	100	0	No	No	No	No	6	1
23	3x23	3x24	adenosine_off	100	0	No	No	No	No	1	5
24	3x23	E2	adenosine_off	100	0	No	No	Yes	Yes	1	3
25	3x32	Lig	adenosine_off	100	0	No	No	Yes	Yes	6	0
26	3x37	3x40	adenosine_off	100	0	Yes	Yes	No	Yes	6	8
27	3x37	4x53	adenosine_off	100	0	Yes	Yes	No	No	6	8
28	3x39	6x44	adenosine_off	100	0	No	No	Yes	Yes	9	9
29	3x41	4x52	adenosine_off	100	0	No	No	No	No	4	4
30	3x43	6x44	adenosine_off	100	0	No	No	Yes	Yes	8	9
31	3x44	5x54	adenosine_off	100	0	No	No	No	No	7	8
32	3x46	6x37	adenosine_off	100	0	No	No	No	No	9	8
33	3x47	5x57	adenosine_off	100	0	No	No	No	No	9	6
34	3x47	5x58	adenosine_off	100	0	No	No	No	Yes	9	9
35	3x49	3x50	adenosine_off	100	0	Yes	Yes	Yes	No	9	9
36	3x49	I2x57	adenosine_off	100	0	Yes	Yes	No	No	9	7
37	3x50	3x53	adenosine_off	100	0	Yes	No	Yes	No	9	8
38	3x50	6x30	adenosine_off	100	0	Yes	No	Yes	Yes	9	6
39	3x50	6x33	adenosine_off	100	0	Yes	No	No	No	9	7
40	3x51	5x61	adenosine_off	100	0	No	No	No	Yes	7	9
41	3x52	I2x53	adenosine_off	100	0	No	No	Yes	Yes	5	7
42	3x53	6x30	adenosine_off	100	0	Yes	No	Yes	Yes	8	6
43	3x54	5x65	adenosine_off	100	0	Yes	No	No	No	9	8
44	4x58	4x61	adenosine_off	100	0	No	No	No	No	4	5
45	5x40	E2x52	adenosine_off	100	0	Yes	Yes	No	No	5	4
46	5x37	6x58	adenosine_off	100	0	No	No	No	No	3	4
47	5x37	6x59	adenosine_off	100	0	No	No	Yes	Yes	3	4
48	5x39	5x40	adenosine_off	100	0	Yes	Yes	Yes	Yes	6	5
49	5x39	5x43	adenosine_off	100	0	Yes	Yes	No	No	6	5
50	5x41	5x45	adenosine_off	100	0	No	No	No	No	4	4
51	5x41	6x56	adenosine_off	100	0	No	No	No	No	4	5
52	5x54	6x41	adenosine_off	100	0	No	No	No	No	8	8
53	5x58	6x38	adenosine_off	100	0	No	Yes	No	No	9	6
54	5x62	6x35	adenosine_off	100	0	No	No	No	No	6	7
55	5x65	6x31	adenosine_off	100	0	No	No	No	No	8	5
56	5x68	6x27	adenosine_off	100	0	No	No	No	No	7	1
57	5x69	6x27	adenosine_off	100	0	No	Yes	No	No	4	1
58	6x40	7x49	adenosine_off	100	0	No	No	Yes	Yes	8	9
59	6x40	7x52	adenosine_off	100	0	No	No	No	No	8	8
60	6x44	7x45	adenosine_off	100	0	Yes	Yes	Yes	No	9	9
61	6x48	Lig	adenosine_off	100	0	Yes	Yes	Yes	Yes	8	0
62	7x32	7x33	adenosine_off	100	0	No	No	No	No	1	4
63	7x35	Lig	adenosine_off	100	0	Yes	Yes	Yes	Yes	3	0
64	7x45	7x48	adenosine_off	100	0	Yes	No	No	No	9	6
65	7x49	7x53	adenosine_off	100	0	Yes	Yes	Yes	Yes	9	9
66	7x53	8x47	adenosine_off	100	0	Yes	Yes	No	No	9	8
67	7x53	8x50	adenosine_off	100	0	Yes	Yes	Yes	Yes	9	9
68	8x50	8x54	adenosine_off	100	0	Yes	Yes	No	Yes	9	7
69	8x58	8x63	adenosine_off	100	0	No	No	No	No	5	4
70	3x33	5x43	adenosine_off	100	0	No	No	No	No	4	5
71	3x54	6x30	adenosine_off	100	0	Yes	No	Yes	Yes	9	6
72	5x38	E2	adenosine_off	100	0	No	No	Yes	Yes	3	3
73	6x26	6x30	adenosine_off	100	0	No	No	Yes	Yes	3	6
74	6x29	8x50	adenosine_off	100	0	No	No	Yes	Yes	6	9
75	6x52	Lig	adenosine_off	100	0	No	No	Yes	Yes	7	0
76	E3	Lig	adenosine_off	100	0	Yes	Yes	Yes	Yes	3	0
77	7x30	7x32	adenosine_off	100	0	No	No	No	No	4	1
78	8x49	I1x49	adenosine_off	100	0	No	No	No	No	6	6
79	E1x50	E2x50	adenosine_off	100	0	Yes	No	No	No	3	9
80	6x32	7x56	adenosine_off	100	0	No	No	Yes	No	7	7
81	8x55	8x59	adenosine_off	100	0	No	No	No	No	5	4
82	E2	E3	adenosine_off	100	0	Yes	Yes	Yes	Yes	3	3
83	1x42	2x57	adenosine_off	25	0	No	No	Yes	Yes	7	6
84	3x43	5x54	adenosine_off	1.92308	0	No	No	No	No	8	8
85	5x69	6x24	adenosine_off	30.7692	0	No	Yes	Yes	No	4	2
86	1x57	I1x50	adenosine_off	51.9231	0	No	No	Yes	Yes	8	8
87	5x47	5x51	adenosine_off	26.9231	0	No	No	No	No	5	6
88	1x47	2x54	adenosine_off	40.3846	0	No	No	No	No	6	7
89	5x62	5x66	adenosine_off	55.7692	0	No	No	No	Yes	6	5
90	1x56	8x53	adenosine_off	75	0	No	No	No	No	8	6
91	2x38	4x42	adenosine_off	50	0	No	No	No	No	6	7
92	I2x56	I2x57	adenosine_off	51.9231	0	No	No	No	No	4	7
93	3x44	3x48	adenosine_off	50	0	No	No	No	No	7	6
94	2x50	Na1	adenosine_off	50	0	Yes	Yes	No	No	9	0
95	6x47	7x40	adenosine_off	23.0769	0	No	No	No	No	8	7
96	5x44	6x49	adenosine_off	0	0	Yes	Yes	No	No	5	7
97	2x62	E1x50	adenosine_off	50	0	No	No	Yes	No	4	3
98	5x63	5x67	adenosine_off	50	0	No	No	No	No	4	4
99	5x51	6x45	adenosine_off	30.7692	0	No	No	No	No	6	6
100	4x56	4x57	adenosine_off	36.5385	0	No	Yes	No	No	5	6
101	7x54	8x54	adenosine_off	0	0	No	No	No	Yes	7	7
102	2x66	E1x50	adenosine_off	50	0	No	No	Yes	No	3	3
103	1x54	2x48	adenosine_off	50	0	No	No	No	No	7	6
104	1x27	1x30	adenosine_off	50	0	No	No	No	No	0	5
105	2x41	4x46	adenosine_off	25	0	No	No	No	No	4	8
106	3x54	5x68	adenosine_off	9.61539	0	Yes	No	No	No	9	7
107	6x32	8x48	adenosine_off	50	0	No	No	No	No	7	4
108	3x56	I2x50	adenosine_off	0	0	No	No	No	No	6	8
109	5x55	5x59	adenosine_off	19.2308	0	No	No	No	No	5	3
110	1x58	2x44	adenosine_off	50	0	No	No	No	No	3	5
111	6x25	6x29	adenosine_off	28.8462	0	No	No	No	No	3	6
112	8x56	8x60	adenosine_off	26.9231	0	No	No	No	No	5	6
113	7x55	7x56	adenosine_off	26.9231	0	No	No	Yes	No	6	7
114	1x44	1x48	adenosine_off	1.92308	0	No	No	No	No	5	4
115	5x56	5x59	adenosine_off	15.3846	0	No	No	No	No	4	3
116	4x41	I2x56	adenosine_off	1.92308	0	No	No	No	No	5	4
117	5x60	5x63	adenosine_off	25	0	No	No	No	No	4	4
118	1x31	7x35	adenosine_off	25	0	No	No	Yes	Yes	4	3
119	6x21	6x24	adenosine_off	9.61539	0	No	No	Yes	No	0	2
120	1x55	8x62	adenosine_off	0	0	Yes	No	No	No	4	3
121	4x59	4x62	adenosine_off	3.84615	0	No	No	No	No	6	4
122	1x30	1x31	adenosine_off	0	0	No	No	No	No	5	4
123	5x52	5x56	adenosine_off	0	0	No	No	No	No	3	4
124	I2x52	I2x55	adenosine_off	0	0	Yes	No	No	No	5	5
125	1x27	1x28	adenosine_off	0	0	No	No	No	No	0	0
126	1x52	8x58	adenosine_off	0	0	No	No	No	No	7	5
127	6x43	6x46	adenosine_off	0	0	No	No	No	No	6	6
128	4x44	4x47	adenosine_off	0	0	No	No	No	No	3	4
129	4x47	4x51	adenosine_off	0	0	No	No	No	No	4	4
130	4x51	4x55	adenosine_off	0	0	No	No	No	No	4	4
131	2x41	4x43	adenosine_off	5.76923	0	No	No	No	No	4	1
132	5x72	I3	adenosine_off	3.84615	0	No	No	No	No	0	4
133	5x72	6x24	adenosine_off	3.84615	0	No	No	Yes	No	0	2
134	6x21	6x22	adenosine_off	3.84615	0	No	No	No	No	0	3
135	5x70	5x73	adenosine_off	0	0	No	No	No	No	0	0
136	6x23	6x26	adenosine_off	1.92308	0	No	No	No	No	4	3
137	8x59	8x64	adenosine_off	1.92308	0	No	No	No	No	4	5
138	1x35	1x39	Shared	100	100	Yes	Yes	Yes	Yes	5	6
139	1x35	2x64	Shared	100	100	Yes	Yes	No	No	5	3
140	1x35	7x35	Shared	100	100	Yes	Yes	Yes	Yes	5	3
141	1x35	7x39	Shared	100	100	Yes	Yes	No	Yes	5	5
142	1x36	2x61	Shared	100	100	No	No	No	No	5	6
143	1x38	7x39	Shared	100	100	No	No	No	Yes	5	5
144	1x39	2x57	Shared	100	100	Yes	Yes	Yes	Yes	6	6
145	1x39	2x61	Shared	100	100	Yes	Yes	No	No	6	6
146	1x39	7x39	Shared	100	100	Yes	Yes	No	Yes	6	5
147	1x39	7x42	Shared	100	100	Yes	Yes	Yes	Yes	6	7
148	1x43	2x57	Shared	100	100	No	No	Yes	Yes	5	6
149	1x45	7x47	Shared	100	41.6667	No	No	No	No	4	6
150	1x50	2x50	Shared	100	100	Yes	No	Yes	Yes	9	9
151	1x50	7x50	Shared	100	100	Yes	No	No	No	9	9
152	1x52	8x54	Shared	100	100	No	No	No	Yes	7	7
153	1x53	2x47	Shared	100	50	No	No	No	No	9	9
154	1x55	1x59	Shared	100	33.3333	Yes	No	No	No	4	5
155	1x57	2x44	Shared	100	100	No	No	No	No	8	5
156	1x60	I1x49	Shared	100	100	Yes	Yes	No	No	6	6
157	1x60	I1x50	Shared	100	100	Yes	Yes	Yes	Yes	6	8
158	1x60	8x53	Shared	100	100	Yes	Yes	No	No	6	6
159	2x40	I1x50	Shared	100	100	No	Yes	Yes	Yes	8	8
160	8x49	I1x50	Shared	100	100	No	No	Yes	Yes	6	8
161	2x37	2x40	Shared	100	100	No	No	No	Yes	7	8
162	2x39	3x49	Shared	100	100	No	No	Yes	Yes	8	9
163	2x40	8x50	Shared	100	100	No	Yes	Yes	Yes	8	9
164	2x42	3x45	Shared	100	33.3333	Yes	Yes	No	No	8	7
165	2x42	4x46	Shared	100	100	Yes	Yes	No	No	8	8
166	2x45	4x46	Shared	100	100	No	No	No	No	9	8
167	2x45	4x50	Shared	100	100	No	No	No	Yes	9	9
168	2x46	7x49	Shared	100	100	No	Yes	Yes	Yes	9	9
169	2x50	7x46	Shared	100	100	Yes	Yes	No	No	9	9
170	2x50	7x49	Shared	100	100	Yes	Yes	Yes	Yes	9	9
171	2x52	3x35	Shared	100	100	No	No	No	Yes	6	7
172	2x53	2x56	Shared	100	100	No	No	No	No	8	6
173	2x53	7x46	Shared	100	100	No	No	No	No	8	9
174	2x56	3x32	Shared	100	100	No	No	No	No	6	6
175	2x57	2x58	Shared	100	100	Yes	Yes	No	No	6	8
176	2x57	7x42	Shared	100	100	Yes	Yes	Yes	Yes	6	7
177	2x59	3x28	Shared	100	100	No	No	No	No	5	6
178	2x59	3x31	Shared	100	66.6667	No	No	Yes	No	5	4
179	E1x51	E2	Shared	100	25	No	No	Yes	Yes	4	3
180	3x24	E1x52	Shared	100	33.3333	No	No	No	No	5	7
181	3x21	E2	Shared	100	100	No	No	Yes	Yes	6	3
182	3x22	E2	Shared	100	100	No	No	Yes	Yes	3	3
183	3x25	E2	Shared	100	100	No	No	Yes	Yes	9	3
184	3x25	E2x50	Shared	100	100	No	No	No	No	9	9
185	3x26	E2	Shared	100	100	No	No	Yes	Yes	5	3
186	3x27	4x61	Shared	100	100	No	No	No	No	4	5
187	3x29	E2	Shared	100	100	No	No	Yes	Yes	4	3
188	3x30	4x60	Shared	100	100	No	No	No	Yes	6	4
189	3x33	5x39	Shared	100	100	No	No	Yes	Yes	4	6
190	3x33	5x40	Shared	100	100	No	No	Yes	Yes	4	5
191	3x34	4x54	Shared	100	100	No	No	No	No	5	3
192	3x34	4x58	Shared	100	33.3333	No	No	No	No	5	4
193	3x36	6x48	Shared	100	100	No	No	Yes	Yes	6	8
194	3x37	3x41	Shared	100	100	Yes	Yes	No	No	6	4
195	3x37	4x56	Shared	100	100	Yes	Yes	No	Yes	6	5
196	3x37	5x461	Shared	100	100	Yes	Yes	Yes	Yes	6	8
197	3x38	4x50	Shared	100	100	No	No	No	Yes	7	9
198	3x38	4x53	Shared	100	100	No	No	No	No	7	8
199	3x40	5x50	Shared	100	50	No	Yes	No	No	8	8
200	3x40	6x44	Shared	100	100	No	Yes	Yes	Yes	8	9
201	3x41	4x49	Shared	100	100	No	No	No	No	4	7
202	3x49	I2x53	Shared	100	100	Yes	Yes	Yes	Yes	9	7
203	3x51	3x55	Shared	100	100	No	No	No	No	7	7
204	3x51	5x60	Shared	100	100	No	No	No	No	7	4
205	3x53	I2x53	Shared	100	100	Yes	No	Yes	Yes	8	7
206	3x54	5x61	Shared	100	100	Yes	No	No	Yes	9	9
207	3x56	I2x52	Shared	100	100	No	No	Yes	No	6	5
208	I2x53	I2x57	Shared	100	100	Yes	Yes	No	No	7	7
209	4x38	4x41	Shared	100	100	No	No	No	No	8	5
210	4x56	5x461	Shared	100	100	No	Yes	Yes	Yes	5	8
211	4x59	4x60	Shared	100	100	No	No	No	Yes	6	4
212	4x59	5x39	Shared	100	100	No	No	Yes	Yes	6	6
213	4x60	5x39	Shared	100	100	No	Yes	Yes	Yes	4	6
214	5x36	E2	Shared	100	100	No	No	Yes	Yes	5	3
215	5x39	E2	Shared	100	100	Yes	Yes	Yes	Yes	6	3
216	5x42	E2	Shared	100	100	No	Yes	Yes	Yes	5	3
217	E2	E2	Shared	100	100	Yes	Yes	Yes	Yes	3	3
218	E2	E2x51	Shared	100	100	Yes	Yes	No	No	3	4
219	E2	E2x52	Shared	100	100	Yes	Yes	No	No	3	4
220	E2x52	Lig	Shared	100	100	No	No	Yes	Yes	4	0
221	E2	Lig	Shared	100	100	Yes	Yes	Yes	Yes	3	0
222	5x36	5x38	Shared	100	100	No	No	No	No	5	3
223	5x37	6x55	Shared	100	100	No	No	No	No	3	5
224	5x39	5x42	Shared	100	100	Yes	Yes	No	Yes	6	5
225	5x40	5x43	Shared	100	100	Yes	Yes	No	No	5	5
226	5x40	6x55	Shared	100	100	Yes	Yes	No	No	5	5
227	5x40	Lig	Shared	100	100	Yes	Yes	Yes	Yes	5	0
228	5x41	6x59	Shared	100	100	No	No	Yes	Yes	4	4
229	5x411	6x59	Shared	100	100	No	No	Yes	Yes	4	4
230	5x411	6x60	Shared	100	100	No	No	No	No	4	4
231	5x42	5x461	Shared	100	100	No	Yes	Yes	Yes	5	8
232	5x44	5x45	Shared	100	100	Yes	Yes	No	No	5	4
233	5x44	5x47	Shared	100	100	Yes	Yes	No	No	5	5
234	5x44	5x48	Shared	100	100	Yes	Yes	No	No	5	5
235	5x44	6x52	Shared	100	100	Yes	Yes	No	No	5	7
236	5x46	5x461	Shared	100	100	No	No	Yes	Yes	5	8
237	5x47	6x52	Shared	100	100	No	No	No	No	5	7
238	5x49	5x50	Shared	100	100	No	No	No	No	4	8
239	5x58	6x37	Shared	100	100	No	Yes	No	No	9	8
240	5x62	6x34	Shared	100	100	No	No	No	No	6	7
241	6x36	7x56	Shared	100	100	No	No	Yes	No	8	7
242	6x39	7x56	Shared	100	33.3333	No	No	Yes	No	6	7
243	6x40	7x53	Shared	100	100	No	No	Yes	Yes	8	9
244	6x44	6x48	Shared	100	100	Yes	Yes	Yes	Yes	9	8
245	6x47	7x45	Shared	100	100	No	No	Yes	No	8	9
246	6x48	7x41	Shared	100	100	Yes	Yes	No	No	8	7
247	6x48	7x45	Shared	100	100	Yes	Yes	Yes	No	8	9
248	6x51	Lig	Shared	100	100	No	Yes	Yes	Yes	6	0
249	6x54	7x34	Shared	100	16.6667	No	No	No	No	4	4
250	6x55	Lig	Shared	100	100	No	No	Yes	Yes	5	0
251	6x59	6x60	Shared	100	100	Yes	Yes	No	No	4	4
252	6x61	E3	Shared	100	100	No	No	Yes	Yes	4	3
253	7x30	7x33	Shared	100	100	No	No	No	No	4	4
254	7x31	7x35	Shared	100	100	No	No	Yes	Yes	3	3
255	7x34	Lig	Shared	100	100	No	No	Yes	Yes	4	0
256	7x38	7x42	Shared	100	100	No	Yes	Yes	Yes	5	7
257	7x38	Lig	Shared	100	100	No	Yes	Yes	Yes	5	0
258	8x47	8x50	Shared	100	100	No	No	Yes	Yes	8	9
259	8x51	8x55	Shared	100	0	No	No	No	No	8	5
260	4x38	4x40	Shared	100	0	No	No	No	No	8	5
261	6x58	E3	Shared	100	100	No	No	Yes	Yes	4	3
262	3x31	3x35	Shared	100	100	Yes	No	No	Yes	4	7
263	4x38	4x39	Shared	53.8462	41.6667	No	No	No	No	8	3
264	6x39	6x43	Shared	50	100	No	No	No	No	6	6
265	1x46	7x46	Shared	51.9231	100	No	No	No	No	8	9
266	6x31	6x35	Shared	75	0	No	No	No	No	5	7
267	6x43	7x48	Shared	19.2308	100	No	No	No	No	6	6
268	6x42	6x46	Shared	50	100	No	No	No	No	5	6
269	I2x52	I2x56	Shared	55.7692	50	Yes	No	No	No	5	4
270	6x51	7x37	Shared	36.5385	16.6667	No	Yes	No	No	6	5
271	1x42	7x43	Shared	25	8.33333	No	No	No	No	7	5
272	1x50	2x51	Shared	3.84615	33.3333	Yes	No	No	No	9	7
273	8x48	8x51	Shared	50	100	No	No	No	No	4	8
274	1x54	2x47	Shared	50	33.3333	No	No	No	No	7	9
275	6x50	7x40	Shared	50	16.6667	No	No	No	No	9	7
276	8x48	8x52	Shared	50	0	No	No	No	No	4	4
277	2x46	3x42	Shared	26.9231	100	No	Yes	No	No	9	8
278	6x53	6x57	Shared	25	0	No	No	No	No	6	4
279	I2x53	I2x54	Shared	50	100	Yes	Yes	No	No	7	4
280	3x27	3x31	Shared	50	100	No	No	Yes	No	4	4
281	I1x48	I1x51	Shared	34.6154	100	No	No	No	No	6	7
282	2x42	4x45	Shared	50	8.33333	Yes	Yes	No	No	8	5
283	1x47	1x48	Shared	50	33.3333	No	No	No	No	6	4
284	6x24	6x28	Shared	50	8.33333	Yes	No	No	No	2	3
285	7x30	E3	Shared	25	100	No	No	Yes	Yes	4	3
286	2x60	7x42	Shared	25	41.6667	No	No	Yes	Yes	7	7
287	1x46	7x47	Shared	25	41.6667	No	No	No	No	8	6
288	2x65	E1x50	Shared	40.3846	33.3333	No	No	Yes	No	4	3
289	3x54	5x64	Shared	25	100	Yes	No	No	No	9	5
290	1x40	2x61	Shared	0	8.33333	No	No	No	No	4	6
291	2x55	2x551	Shared	19.2308	100	No	No	No	No	4	5
292	8x60	8x61	Shared	36.5385	100	No	No	No	No	6	6
293	2x49	4x50	Shared	0	0	No	No	No	Yes	8	9
294	6x57	E3	Shared	50	16.6667	No	No	Yes	Yes	4	3
295	4x63	E2	Shared	13.4615	33.3333	No	No	Yes	Yes	5	3
296	1x37	1x40	Shared	25	0	No	No	No	No	5	4
297	7x51	7x55	Shared	1.92308	33.3333	No	No	No	No	7	6
298	4x48	4x51	Shared	25	33.3333	No	No	No	No	1	4
299	4x48	4x52	Shared	0	8.33333	No	No	No	No	1	4
300	5x48	5x52	Shared	19.2308	100	No	No	No	No	5	3
301	3x44	5x53	Shared	0	33.3333	No	No	No	No	7	6
302	2x41	I1x51	Shared	15.3846	0	No	No	No	No	4	7
303	I2x51	I2x52	Shared	3.84615	33.3333	No	No	Yes	No	6	5
304	7x32	7x36	Shared	0	66.6667	No	No	No	No	1	3
305	1x29	1x33	Shared	0	0	No	No	No	No	6	5
306	1x34	1x38	Shared	0	33.3333	No	No	No	No	4	5
307	1x29	1x30	Shared	0	8.33333	No	No	No	No	6	5
308	1x41	1x45	Shared	0	41.6667	No	No	No	No	5	4
309	5x68	5x71	Shared	0	41.6667	No	No	No	No	7	0
310	5x66	5x70	Shared	0	100	No	Yes	No	No	5	0
311	1x29	1x32	adenosine_on	0	100	No	No	No	No	6	4
312	1x31	7x32	adenosine_on	0	100	No	No	No	No	4	1
313	1x32	7x35	adenosine_on	0	100	No	No	Yes	Yes	4	3
314	1x35	7x38	adenosine_on	0	100	Yes	Yes	No	Yes	5	5
315	1x53	8x50	adenosine_on	0	100	No	No	Yes	Yes	9	9
316	1x56	8x50	adenosine_on	0	100	No	No	Yes	Yes	8	9
317	8x53	I1x50	adenosine_on	0	100	No	No	Yes	Yes	6	8
318	2x39	3x53	adenosine_on	0	100	No	No	Yes	No	8	8
319	2x40	2x43	adenosine_on	0	100	No	Yes	No	No	8	8
320	2x40	8x47	adenosine_on	0	100	No	Yes	No	No	8	8
321	2x41	4x42	adenosine_on	0	100	No	No	No	No	4	7
322	2x42	3x49	adenosine_on	0	100	Yes	Yes	Yes	Yes	8	9
323	2x42	4x42	adenosine_on	0	100	Yes	Yes	No	No	8	7
324	2x46	2x50	adenosine_on	0	100	No	Yes	Yes	Yes	9	9
325	2x46	3x43	adenosine_on	0	100	No	Yes	No	No	9	8
326	2x50	3x39	adenosine_on	0	100	Yes	Yes	No	No	9	9
327	2x551	3x35	adenosine_on	0	100	No	No	No	Yes	5	7
328	2x56	3x35	adenosine_on	0	100	No	No	No	Yes	6	7
329	2x64	7x35	adenosine_on	0	100	No	No	Yes	Yes	3	3
330	E1x50	E1x52	adenosine_on	0	100	Yes	No	No	No	3	7
331	3x26	4x61	adenosine_on	0	100	No	No	No	No	5	5
332	3x30	4x61	adenosine_on	0	100	No	No	No	No	6	5
333	3x33	Lig	adenosine_on	0	100	No	No	Yes	Yes	4	0
334	3x34	4x57	adenosine_on	0	100	No	No	No	No	5	6
335	3x36	Lig	adenosine_on	0	100	No	No	Yes	Yes	6	0
336	3x37	5x43	adenosine_on	0	100	Yes	Yes	No	No	6	5
337	3x40	6x48	adenosine_on	0	100	No	Yes	Yes	Yes	8	8
338	3x43	7x49	adenosine_on	0	100	No	No	Yes	Yes	8	9
339	3x43	7x53	adenosine_on	0	100	No	No	Yes	Yes	8	9
340	3x46	3x50	adenosine_on	0	100	No	No	Yes	No	9	9
341	3x46	7x53	adenosine_on	0	100	No	No	Yes	Yes	9	9
342	3x47	5x54	adenosine_on	0	100	No	No	No	No	9	8
343	3x49	3x53	adenosine_on	0	100	Yes	Yes	Yes	No	9	8
344	3x50	5x58	adenosine_on	0	100	Yes	No	No	Yes	9	9
345	3x50	7x53	adenosine_on	0	100	Yes	No	Yes	Yes	9	9
346	3x51	5x57	adenosine_on	0	100	No	No	No	No	7	6
347	3x52	3x56	adenosine_on	0	100	No	No	No	No	5	6
348	4x52	5x461	adenosine_on	0	100	No	No	Yes	Yes	4	8
349	4x56	5x42	adenosine_on	0	100	No	Yes	No	Yes	5	5
350	4x60	E2	adenosine_on	0	100	No	Yes	Yes	Yes	4	3
351	5x38	6x59	adenosine_on	0	100	No	No	Yes	Yes	3	4
352	5x51	6x44	adenosine_on	0	100	No	No	Yes	Yes	6	9
353	5x54	5x58	adenosine_on	0	100	No	No	No	Yes	8	9
354	5x54	6x44	adenosine_on	0	100	No	No	Yes	Yes	8	9
355	5x55	6x41	adenosine_on	0	100	No	No	No	No	5	8
356	5x58	6x40	adenosine_on	0	100	No	Yes	No	No	9	8
357	5x58	6x41	adenosine_on	0	100	No	Yes	No	No	9	8
358	5x62	6x30	adenosine_on	0	100	No	No	Yes	Yes	6	6
359	5x63	5x66	adenosine_on	0	100	No	No	No	Yes	4	5
360	6x25	6x26	adenosine_on	0	100	No	No	No	No	3	3
361	6x51	7x38	adenosine_on	0	100	No	Yes	No	Yes	6	5
362	6x51	7x41	adenosine_on	0	100	No	Yes	No	No	6	7
363	6x54	E3	adenosine_on	0	100	No	No	Yes	Yes	4	3
364	E3	E3	adenosine_on	0	100	Yes	Yes	Yes	Yes	3	3
365	7x42	Lig	adenosine_on	0	100	Yes	Yes	Yes	Yes	7	0
366	7x45	7x49	adenosine_on	0	100	Yes	No	Yes	Yes	9	9
367	7x52	7x53	adenosine_on	0	100	No	No	Yes	Yes	8	9
368	7x54	8x50	adenosine_on	0	100	No	No	Yes	Yes	7	9
369	7x55	8x51	adenosine_on	0	100	No	No	No	No	6	8
370	2x41	4x39	adenosine_on	0	100	No	No	No	No	4	3
371	5x59	5x63	adenosine_on	0	100	No	No	No	No	3	4
372	5x66	6x30	adenosine_on	0	100	No	Yes	Yes	Yes	5	6
373	5x69	6x29	adenosine_on	0	100	No	Yes	No	No	4	6
374	3x22	3x23	adenosine_on	0	100	No	No	No	No	3	1
375	1x54	2x44	adenosine_on	0	66.6667	No	No	No	No	7	5
376	2x37	2x39	adenosine_on	0	50	No	No	No	No	7	8
377	2x62	3x28	adenosine_on	0	41.6667	No	No	No	No	4	6
378	2x45	3x42	adenosine_on	0	50	No	No	No	No	9	8
379	3x44	5x50	adenosine_on	0	83.3333	No	No	No	No	7	8
380	3x21	3x24	adenosine_on	0	33.3333	No	No	No	No	6	5
381	2x53	2x54	adenosine_on	0	83.3333	No	No	No	No	8	7
382	7x36	7x39	adenosine_on	0	33.3333	No	No	No	Yes	3	5
383	7x55	8x54	adenosine_on	0	50	No	No	No	Yes	6	7
384	5x73	6x26	adenosine_on	0	33.3333	No	No	No	No	0	3
385	2x38	I2x53	adenosine_on	0	33.3333	No	No	Yes	Yes	6	7
386	6x45	6x49	adenosine_on	0	33.3333	No	No	No	No	6	7
387	6x56	6x60	adenosine_on	0	33.3333	No	No	No	No	5	4
388	8x54	8x58	adenosine_on	0	33.3333	No	Yes	No	No	7	5
389	3x40	5x47	adenosine_on	0	33.3333	No	Yes	No	No	8	5
390	1x47	2x55	adenosine_on	0	33.3333	No	No	No	No	6	4
391	1x42	7x47	adenosine_on	0	33.3333	No	No	No	No	7	6
392	4x50	4x54	adenosine_on	0	8.33333	No	Yes	No	No	9	3
393	5x51	6x49	adenosine_on	0	33.3333	No	No	No	No	6	7
394	5x65	6x33	adenosine_on	0	33.3333	No	No	No	No	8	7
395	5x57	5x61	adenosine_on	0	8.33333	No	No	No	Yes	6	9
396	5x66	5x67	adenosine_on	0	33.3333	No	Yes	No	No	5	4
397	4x40	4x43	adenosine_on	0	50	No	No	No	No	5	1
398	3x55	3x56	adenosine_on	0	33.3333	No	No	No	No	7	6
399	5x61	6x37	adenosine_on	0	33.3333	No	Yes	No	No	9	8
400	2x63	3x28	adenosine_on	0	33.3333	No	No	No	No	3	6
401	2x66	E2	adenosine_on	0	33.3333	No	No	Yes	Yes	3	3
402	5x69	6x30	adenosine_on	0	8.33333	No	Yes	Yes	Yes	4	6
403	6x27	6x31	adenosine_on	0	33.3333	No	No	No	No	1	5
404	1x48	1x49	adenosine_on	0	0	No	No	No	No	4	8
405	6x49	6x50	adenosine_on	0	0	No	No	No	No	7	9
406	I2x55	I2x56	adenosine_on	0	8.33333	No	No	No	No	5	4
407	6x27	6x30	adenosine_on	0	16.6667	No	No	Yes	Yes	1	6
408	6x43	7x52	adenosine_on	0	16.6667	No	No	No	No	6	8
409	3x48	5x57	adenosine_on	0	0	No	No	No	No	6	6
410	5x61	5x65	adenosine_on	0	0	No	Yes	No	No	9	8
411	1x56	8x54	adenosine_on	0	33.3333	No	No	No	Yes	8	7
412	6x29	6x32	adenosine_on	0	33.3333	No	No	No	No	6	7
413	5x62	6x37	adenosine_on	0	8.33333	No	No	No	No	6	8
414	I2x50	I2x51	adenosine_on	0	33.3333	No	No	No	No	8	6
415	6x25	6x28	adenosine_on	0	33.3333	No	No	No	No	3	3
416	6x46	7x40	adenosine_on	0	0	No	No	No	No	6	7
417	6x38	6x42	adenosine_on	0	33.3333	No	No	No	No	6	5
418	2x48	4x50	adenosine_on	0	16.6667	No	No	No	Yes	6	9
419	8x53	8x57	adenosine_on	0	16.6667	No	No	No	No	6	7
420	8x57	8x61	adenosine_on	0	16.6667	No	No	No	No	7	6
421	5x69	5x73	adenosine_on	0	33.3333	No	Yes	No	No	4	0
422	1x58	I1x51	adenosine_on	0	16.6667	No	No	No	No	3	7
423	2x65	NT	adenosine_on	0	8.33333	No	No	No	No	4	0
424	1x47	1x51	adenosine_on	0	0	No	No	No	No	6	5
425	1x59	1x60	adenosine_on	0	16.6667	No	No	Yes	Yes	5	6
426	8x52	8x56	adenosine_on	0	8.33333	No	No	No	No	4	5
427	1x40	1x44	adenosine_on	0	0	No	No	No	No	4	5
428	5x64	5x68	adenosine_on	0	0	No	No	No	No	5	7
429	8x58	8x59	adenosine_on	0	0	No	No	No	No	5	4
430	5x56	5x60	adenosine_on	0	8.33333	No	No	No	No	4	4
431	4x58	4x62	adenosine_on	0	16.6667	No	No	No	No	4	4
432	4x40	4x44	adenosine_on	0	0	No	No	No	No	5	3
433	4x46	4x47	adenosine_on	0	0	No	No	No	No	8	4
434	4x55	4x56	adenosine_on	0	0	No	No	No	Yes	4	5
435	5x69	5x72	adenosine_on	0	8.33333	No	Yes	No	No	4	0
436	6x29	I3	adenosine_on	0	8.33333	No	No	No	No	6	4

Orange: nodes, hubs and links specific of adenosine_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of adenosine_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	adenosine_off Avg Int. Strength	adenosine_on Avg Int. Strength	adenosine_off Num Of Links	adenosine_on Num Of Links	ConSurf
1	1x50	adenosine_off	0	33.3333	4	3	9
2	1x55	adenosine_off	0	0	4	1	4
3	E1x50	adenosine_off	0	0	4	2	3
4	3x31	adenosine_off	36.5385	0	4	3	4
5	3x50	adenosine_off	78.8462	0	5	3	9
6	3x53	adenosine_off	50	0	4	3	8
7	3x54	adenosine_off	0	0	5	2	9
8	I2x52	adenosine_off	0	0	4	3	5
9	6x24	adenosine_off	0	0	4	1	2
10	7x45	adenosine_off	25	0	4	3	9
11	7x56	adenosine_off	0	0	4	2	7
12	1x35	Shared	25	91.6667	4	5	5
13	1x39	Shared	48.0769	75	5	5	6
14	1x60	Shared	50	0	4	4	6
15	I1x50	Shared	48.0769	25	5	4	8
16	2x42	Shared	23.0769	16.6667	4	5	8
17	2x50	Shared	25	100	4	5	9
18	2x57	Shared	94.2308	66.6667	6	4	6
19	3x37	Shared	100	58.3333	5	4	6
20	3x49	Shared	40.3846	0	5	4	9
21	I2x53	Shared	44.2308	100	5	5	7
22	E2	Shared	100	100	18	17	3
23	5x39	Shared	100	83.3333	7	5	6
24	5x40	Shared	80.7692	58.3333	6	4	5
25	5x44	Shared	71.1538	100	5	4	5
26	5x461	Shared	50	66.6667	4	5	8
27	6x30	Shared	0	0	4	4	6
28	6x44	Shared	100	16.6667	5	4	9
29	6x48	Shared	63.4615	100	5	5	8
30	6x59	Shared	73.0769	16.6667	4	4	4
31	E3	Shared	38.4615	58.3333	6	7	3
32	7x35	Shared	0	33.3333	4	4	3
33	7x42	Shared	50	75	4	5	7
34	7x49	Shared	25	75	4	4	9
35	7x53	Shared	75	91.6667	6	5	9
36	8x50	Shared	75	58.3333	6	5	9
37	Lig	Shared	100	100	12	10	0
38	2x40	adenosine_on	32.6923	66.6667	3	5	8
39	2x46	adenosine_on	0	41.6667	2	4	9
40	3x35	adenosine_on	0	33.3333	3	4	7
41	3x40	adenosine_on	0	33.3333	3	4	8
42	4x50	adenosine_on	0	0	3	5	9
43	4x56	adenosine_on	0	0	3	4	5
44	4x60	adenosine_on	0	66.6667	3	4	4
45	5x42	adenosine_on	5.76923	50	3	4	5
46	5x58	adenosine_on	0	50	3	5	9
47	5x61	adenosine_on	0	0	2	4	9
48	5x66	adenosine_on	0	0	2	4	5
49	5x69	adenosine_on	0	0	2	4	4
50	6x51	adenosine_on	0	0	2	4	6
51	7x38	adenosine_on	0	66.6667	2	4	5
52	7x39	adenosine_on	0	33.3333	3	4	5
53	8x54	adenosine_on	0	0	3	4	7

Orange: nodes, hubs and links specific of adenosine_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of adenosine_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	adenosine_off Recurrence	adenosine_on Recurrence	adenosine_off Hub1?	adenosine_on Hub1?	adenosine_off Hub2?	adenosine_on Hub2?	ConSurf1	ConSurf2
1	1x39	2x61	adenosine_off	10.2888	7.53466	Yes	Yes	No	No	6	6
2	7x35	Lig	adenosine_off	22.0819	0	Yes	Yes	Yes	Yes	3	0
3	3x32	Lig	adenosine_off	100	0	No	No	Yes	Yes	6	0
4	2x56	3x32	adenosine_off	99.7802	2.34768	No	No	No	No	6	6
5	1x50	2x50	adenosine_off	10.7672	7.20323	Yes	No	Yes	Yes	9	9
6	7x49	7x53	adenosine_off	78.2112	0	Yes	Yes	Yes	Yes	9	9
7	7x53	8x50	adenosine_off	79.8319	0	Yes	Yes	Yes	Yes	9	9
8	8x50	8x54	adenosine_off	14.2069	0	Yes	Yes	No	Yes	9	7
9	1x52	8x54	adenosine_off	11.7931	1.87262	No	No	No	Yes	7	7
10	8x50	I1x50	adenosine_off	10.7328	0	Yes	Yes	Yes	Yes	9	8
11	2x37	3x53	adenosine_off	59.0905	0	No	No	Yes	No	7	8
12	3x53	I2x53	adenosine_off	21.7716	0.762305	Yes	No	Yes	Yes	8	7
13	5x42	5x461	adenosine_off	32.3836	8.03734	No	Yes	Yes	Yes	5	8
14	3x37	5x461	adenosine_off	28.8405	1.0385	Yes	Yes	Yes	Yes	6	8
15	3x37	4x53	adenosine_off	37.2931	0	Yes	Yes	No	No	6	8
16	3x38	4x53	adenosine_off	35.3664	1.87262	No	No	No	No	7	8
17	3x38	4x50	adenosine_off	33.431	3.73971	No	No	No	Yes	7	9
18	6x48	Lig	adenosine_off	53.7586	0	Yes	Yes	Yes	Yes	8	0
19	3x40	6x44	adenosine_off	29.25	4.4302	No	Yes	Yes	Yes	8	9
20	3x37	3x40	adenosine_off	26.8319	0	Yes	Yes	No	Yes	6	8
21	2x42	3x46	adenosine_off	11.5647	0	Yes	Yes	No	No	8	9
22	2x53	3x35	adenosine_off	15.8534	0	No	No	No	Yes	8	7
23	3x37	3x41	adenosine_off	16.4095	3.61818	Yes	Yes	No	No	6	4
24	3x41	4x52	adenosine_off	12.3578	0	No	No	No	No	4	4
25	I2x53	I2x57	adenosine_off	14.4569	2.06043	Yes	Yes	No	No	7	7
26	3x53	6x30	adenosine_off	33.2759	0	Yes	No	Yes	Yes	8	6
27	3x54	6x30	adenosine_off	31.9095	0	Yes	No	Yes	Yes	9	6
28	3x54	5x65	adenosine_off	10.4914	0	Yes	No	No	No	9	8
29	I2x56	I2x57	adenosine_off	14.694	0	No	No	No	No	4	7
30	6x52	Lig	adenosine_off	17.7802	0	No	No	Yes	Yes	7	0
31	5x44	6x52	adenosine_off	12.8534	0.0165718	Yes	Yes	No	No	5	7
32	3x54	5x68	adenosine_off	12.4612	0	Yes	No	No	No	9	7
33	5x68	6x27	adenosine_off	10.2198	0	No	No	No	No	7	1
34	7x45	7x48	adenosine_off	18.0345	0	Yes	No	No	No	9	6
35	6x43	7x48	adenosine_off	16.9052	2.19301	No	No	No	No	6	6
36	6x39	6x43	adenosine_off	13.4655	6.36911	No	No	No	No	6	6
37	6x39	7x56	adenosine_off	12.2759	4.18715	No	No	Yes	No	6	7
38	7x38	7x42	adenosine_off	19.6767	0.320389	No	Yes	Yes	Yes	5	7
39	4x48	4x52	adenosine_off	10.319	3.04369	No	No	No	No	1	4
40	2x57	7x42	adenosine_off	11.1681	4.15401	Yes	Yes	Yes	Yes	6	7
41	1x35	7x35	Shared	14	14.3125	Yes	Yes	Yes	Yes	5	3
42	2x53	2x56	Shared	99.4267	26.9292	No	No	No	No	8	6
43	2x53	7x46	Shared	93.9224	30.4425	No	No	No	No	8	9
44	2x50	7x46	Shared	91.4655	45.3682	Yes	Yes	No	No	9	9
45	2x50	7x49	Shared	82.0991	27.7799	Yes	Yes	Yes	Yes	9	9
46	2x40	8x50	Shared	58.5819	32.6852	No	Yes	Yes	Yes	8	9
47	2x37	2x40	Shared	60.0991	52.7537	No	No	No	Yes	7	8
48	E2	Lig	Shared	47.0388	49.362	Yes	Yes	Yes	Yes	3	0
49	5x42	E2	Shared	30.8448	12.5835	No	Yes	Yes	Yes	5	3
50	2x45	4x50	Shared	29.5345	18.2787	No	No	No	Yes	9	9
51	2x45	4x46	Shared	27.5733	85.6156	No	No	No	No	9	8
52	2x42	4x46	Shared	17.6379	83.0636	Yes	Yes	No	No	8	8
53	6x44	6x48	Shared	32.9483	42.9155	Yes	Yes	Yes	Yes	9	8
54	3x31	3x35	Shared	13.2759	15.3842	Yes	No	No	Yes	4	7
55	6x48	7x45	Shared	18.7845	69.1874	Yes	Yes	Yes	No	8	9
56	7x38	Lig	Shared	20.6207	19.7978	No	Yes	Yes	Yes	5	0
57	1x35	7x39	adenosine_on	3.81897	13.9093	Yes	Yes	No	Yes	5	5
58	7x36	7x39	adenosine_on	0	11.197	No	No	No	Yes	3	5
59	1x35	7x38	adenosine_on	0	31.6798	Yes	Yes	No	Yes	5	5
60	1x39	7x42	adenosine_on	6.34914	16.489	Yes	Yes	Yes	Yes	6	7
61	6x51	7x38	adenosine_on	0	14.1413	No	Yes	No	Yes	6	5
62	6x51	7x41	adenosine_on	0	16.1189	No	Yes	No	No	6	7
63	6x48	7x41	adenosine_on	1.26293	16.4448	Yes	Yes	No	No	8	7
64	7x45	7x49	adenosine_on	0	68.4251	Yes	No	Yes	Yes	9	9
65	1x46	7x46	adenosine_on	5.46121	14.3457	No	No	No	No	8	9
66	3x36	Lig	adenosine_on	0	82.92	No	No	Yes	Yes	6	0
67	3x36	6x48	adenosine_on	1.26293	83.3729	No	No	Yes	Yes	6	8
68	2x46	7x49	adenosine_on	2.77155	50.6159	No	Yes	Yes	Yes	9	9
69	2x46	3x42	adenosine_on	1.38793	100	No	Yes	No	No	9	8
70	2x45	3x42	adenosine_on	0	98.8621	No	No	No	No	9	8
71	2x42	3x49	adenosine_on	0	63.8292	Yes	Yes	Yes	Yes	8	9
72	2x39	3x49	adenosine_on	0.0603448	54.9412	No	No	Yes	Yes	8	9
73	2x37	2x39	adenosine_on	0	54.3004	No	No	No	No	7	8
74	1x56	8x50	adenosine_on	0	21.1954	No	No	Yes	Yes	8	9
75	1x56	8x54	adenosine_on	0	19.6763	No	No	No	Yes	8	7
76	2x40	I1x50	adenosine_on	2.24569	17.3452	No	Yes	Yes	Yes	8	8
77	2x42	4x42	adenosine_on	0	19.9746	Yes	Yes	No	No	8	7
78	2x41	4x42	adenosine_on	0	18.2732	No	No	No	No	4	7
79	3x43	7x49	adenosine_on	0	22.8581	No	No	Yes	Yes	8	9
80	3x26	E2	adenosine_on	0.99569	13.0476	No	No	Yes	Yes	5	3
81	3x26	4x61	adenosine_on	0	12.0588	No	No	No	No	5	5
82	3x27	4x61	adenosine_on	5.46121	11.882	No	No	No	No	4	5
83	3x27	3x31	adenosine_on	6.80603	11.6113	No	No	Yes	No	4	4
84	2x56	3x35	adenosine_on	0	24.6644	No	No	No	Yes	6	7
85	2x551	3x35	adenosine_on	0	13.9148	No	No	No	Yes	5	7
86	2x55	2x551	adenosine_on	1.375	11.6224	No	No	No	No	4	5
87	2x59	3x31	adenosine_on	2.60345	10.1364	No	No	Yes	No	5	4
88	3x40	6x48	adenosine_on	0	13.4232	No	Yes	Yes	Yes	8	8
89	3x43	7x53	adenosine_on	0	76.8215	No	No	Yes	Yes	8	9
90	5x54	6x44	adenosine_on	0	39.3471	No	No	Yes	Yes	8	9
91	5x54	5x58	adenosine_on	0	39.0046	No	No	No	Yes	8	9
92	3x50	5x58	adenosine_on	0	36.3255	Yes	No	No	Yes	9	9
93	5x58	6x37	adenosine_on	7.85776	94.2551	No	Yes	No	No	9	8
94	5x61	6x37	adenosine_on	0	48.2351	No	Yes	No	No	9	8
95	5x57	5x61	adenosine_on	0	32.1659	No	No	No	Yes	6	9
96	3x51	5x57	adenosine_on	0	27.338	No	No	No	No	7	6
97	3x51	3x55	adenosine_on	1.42672	20.0133	No	No	No	No	7	7
98	3x55	3x56	adenosine_on	0	17.5496	No	No	No	No	7	6
99	3x56	I2x52	adenosine_on	3.00431	12.5891	No	No	Yes	No	6	5
100	2x41	4x39	adenosine_on	0	11.0976	No	No	No	No	4	3
101	5x36	E2	adenosine_on	1.27586	10.5121	No	No	Yes	Yes	5	3
102	5x51	6x44	adenosine_on	0	12.81	No	No	Yes	Yes	6	9
103	5x58	6x40	adenosine_on	0	35.7178	No	Yes	No	No	9	8
104	5x62	6x37	adenosine_on	0	48.5776	No	No	No	No	6	8
105	5x62	6x30	adenosine_on	0	44.164	No	No	Yes	Yes	6	6
106	5x66	6x30	adenosine_on	0	12.578	No	Yes	Yes	Yes	5	6
107	5x69	6x30	adenosine_on	0	22.9354	No	Yes	Yes	Yes	4	6
108	5x69	5x73	adenosine_on	0	11.3683	No	Yes	No	No	4	0
109	7x52	7x53	adenosine_on	0	12.7437	No	No	Yes	Yes	8	9
110	6x43	7x52	adenosine_on	0	10.5949	No	No	No	No	6	8
111	5x51	6x49	adenosine_on	0	11.2468	No	No	No	No	6	7
112	7x34	Lig	adenosine_on	2.20259	13.0586	No	No	Yes	Yes	4	0
113	6x54	7x34	adenosine_on	1.09052	11.882	No	No	No	No	4	4
114	6x54	E3	adenosine_on	0	10.4182	No	No	Yes	Yes	4	3
115	7x55	8x54	adenosine_on	0	13.042	No	No	No	Yes	6	7
116	1x46	7x47	adenosine_on	4.10776	11.9814	No	No	No	No	8	6
117	7x42	Lig	adenosine_on	0	22.5432	Yes	Yes	Yes	Yes	7	0
118	2x46	2x50	adenosine_on	0	28.0506	No	Yes	Yes	Yes	9	9
119	2x46	3x43	adenosine_on	0	54.9301	No	Yes	No	No	9	8
120	3x50	7x53	adenosine_on	0	35.3588	Yes	No	Yes	Yes	9	9
121	6x40	7x53	adenosine_on	0.633621	35.5024	No	No	Yes	Yes	8	9

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
1x32	2x64	adenosine_off	5.31135	0	0	0	2	2
1x35	1x39	Shared	15.3442	15.62	4	1	2	2
1x35	2x64	Shared	7.36154	5.295	4	1	2	2
1x35	7x35	Shared	12.2402	16.76	4	1	2	1
1x39	2x57	Shared	8.06615	6.25333	4	1	2	2
1x39	7x42	Shared	11.6477	12.6175	4	1	2	1
2x56	3x32	Shared	4.00231	4.11333	0	0	2	1
2x57	7x42	Shared	7.49538	4.53	4	1	2	1
E1x51	E2	Shared	9.04731	1.28917	0	0	2	1
3x21	3x23	adenosine_off	4.0825	0	1	1	2	2
3x21	E2	Shared	6.03	4.20833	1	1	2	1
3x22	E2	Shared	24.5831	23.6783	0	1	2	1
3x23	E2	adenosine_off	8.77	0	1	0	2	1
3x25	E2	Shared	7.32115	4.27	1	1	2	1
3x26	E2	Shared	12.4958	9.25917	0	1	2	1
3x29	E2	Shared	3.42308	4.84833	0	0	2	1
3x32	Lig	adenosine_off	4.50096	0	0	0	1	0
3x33	5x39	Shared	5.07462	4.1025	1	1	1	2
3x33	5x40	Shared	3.88731	4.12333	1	1	1	1
3x36	6x48	Shared	7.55173	3.84083	0	0	1	1
3x40	6x44	Shared	5.69846	3.7675	0	4	2	2
4x60	5x39	Shared	14.8723	12.1708	1	1	2	2
5x36	E2	Shared	14.4719	7.61	1	1	2	1
5x39	E2	Shared	13.9108	10.19	1	1	2	1
5x42	E2	Shared	6.40058	5.345	1	1	2	1
E2	E2	Shared	74.7625	51.2233	1	1	1	1
E2	E2x51	Shared	10.586	7.3275	1	1	1	2
E2	E2x52	Shared	12.6042	10.8833	1	1	1	1
5x40	E2x52	adenosine_off	4.61712	0	1	1	1	1
E2x52	Lig	Shared	38.2187	32.1217	1	1	1	0
E2	Lig	Shared	7.21654	5.77167	1	1	1	0
5x36	5x38	Shared	5.25731	6.165	1	1	2	2
5x37	6x55	Shared	6.47212	5.37583	0	0	2	1
5x37	6x58	adenosine_off	3.47365	0	0	0	2	2
5x39	5x40	adenosine_off	4.55673	0	1	1	2	1
5x39	5x42	Shared	8.45039	7.6525	1	1	2	2
5x39	5x43	adenosine_off	6.17115	0	1	1	2	2
5x40	5x43	Shared	5.01462	4.155	1	1	1	2
5x40	6x55	Shared	4.09942	3.505	1	1	1	1
5x40	Lig	Shared	4.23885	5.57083	1	1	1	0
5x44	5x47	Shared	4.99058	4.72333	1	4	2	2
5x44	6x52	Shared	24.3246	15.8433	1	4	2	1
5x47	6x52	Shared	6.70712	7.66417	1	4	2	1
6x44	6x48	Shared	15.6906	12.525	1	4	2	1
6x44	7x45	adenosine_off	7.41289	0	1	4	2	2
6x48	7x41	Shared	10.7744	4.8	1	4	1	2
6x48	7x45	Shared	3.45519	7.25083	1	4	1	2
6x48	Lig	adenosine_off	4.57904	0	1	4	1	0
6x51	Lig	Shared	16.6227	6.7975	0	1	1	0
6x54	7x34	Shared	3.52558	2.21667	0	6	2	1
6x55	Lig	Shared	12.8058	6.8775	1	1	1	0
6x61	E3	Shared	10.96	4.99167	0	0	2	1
7x31	7x35	Shared	6.52846	6.95667	0	0	2	1
7x34	Lig	Shared	4.35096	5.3825	0	0	1	0
7x35	Lig	adenosine_off	5.90577	0	0	1	1	0
7x38	7x42	Shared	4.66769	4.8625	0	1	1	1
7x38	Lig	Shared	9.50423	11.2183	0	1	1	0
3x33	5x43	adenosine_off	4.3325	0	1	1	1	2
5x38	E2	adenosine_off	5.30404	0	1	0	2	1
6x52	Lig	adenosine_off	3.42154	0	1	4	1	0
6x58	E3	Shared	7.41231	5.40417	0	0	2	1
E3	Lig	adenosine_off	3.63135	0	1	6	1	0
E2	E3	adenosine_off	4.23808	0	1	1	1	1
6x51	7x37	Shared	2.72789	2.46833	0	1	1	2
7x30	E3	Shared	2.1525	3.68583	1	6	2	1
2x60	7x42	Shared	2.14096	2.55917	0	0	2	1
6x57	E3	Shared	1.925	1.69833	0	6	2	1
4x63	E2	Shared	1.535	1.93167	0	0	2	1
1x31	7x35	adenosine_off	1.06038	0	0	0	2	1
1x32	7x35	adenosine_on	0	4.44833	0	0	2	1
1x35	7x38	adenosine_on	0	6.95083	4	1	2	1
2x64	7x35	adenosine_on	0	3.38667	0	1	2	1
3x33	Lig	adenosine_on	0	3.65667	1	1	1	0
3x36	Lig	adenosine_on	0	10.7333	0	0	1	0
3x40	6x48	adenosine_on	0	14.0942	0	4	2	1
4x60	E2	adenosine_on	0	3.88583	1	1	2	1
6x51	7x38	adenosine_on	0	3.45833	0	1	1	1
6x51	7x41	adenosine_on	0	5.17083	0	1	1	2
6x54	E3	adenosine_on	0	3.32333	0	6	2	1
E3	E3	adenosine_on	0	3.6975	1	6	1	1
7x42	Lig	adenosine_on	0	6.34583	4	1	1	0
3x22	3x23	adenosine_on	0	3.4375	0	1	2	2
3x40	5x47	adenosine_on	0	2.52833	0	4	2	2
2x66	E2	adenosine_on	0	1.90833	0	0	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	adenosine_off	a1_off a2_off
	adenosine_on	a1_on a2_on a3_on

Network Difference
Value	adenosine_off	adenosine_on
I_min	3.17865	3.21167
Number of Linked Nodes	275	267
Number of Specific Nodes	9 (3.27%)	1 (0.37%)
Number of Shared Nodes	266 (96.73%)	266 (99.63%)
Number of Links	310	299
Number of Specific Links	137 (44.19%)	126 (42.14%)
Number of Shared Links	173 (55.81%)	173 (57.86%)
Number of Hubs	37	42
Number of Specific Hubs	11 (29.73%)	16 (38.10%)
Number of Shared Hubs	26 (70.27%)	26 (61.90%)
Average % Shared Neighbours (Jaccard)	43.59
Average % Shared Neighbours (Otsuka)	53.35
Average % Shared Neighbours (Overlap Coefficient)	62.94
Average % Shared Cliques (k3-6)	55.36
Graphlets Similarity	0.586886

Paths Difference
Value	adenosine_off	adenosine_on
Number Of Nodes in MetaPath	57	76
Specific Nodes in MetaPath	26 (45.61%)	45 (59.21%)
Shared Nodes in MetaPath	266 (96.73%)	266 (96.73%)
Number Of Links MetaPath	56	81
Specific Links in MetaPath	40 (71.43%)	65 (80.25%)
Shared Links in MetaPath	173 (55.81%)	173 (55.81%)
Number of Shortest Paths	46028	47721
Length Of Smallest Path	3	3
Average Path Length	13.9177	13.5216
Length of Longest Path	36	30
Minimum Path Strength	0.395	0.62
Average Path Strength	5.84784	5.41077
Maximum Path Strength	21.9883	21.67
Minimum Path Correlation	0.700192	0.701667
Average Path Correlation	0.917185	0.920407
Maximum Path Correlation	0.99	0.99
Minimum % Of Corr. Nodes	3.125	4.16667
Average % Of Corr. Nodes	45.3629	44.2879
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	42.1282	42.7844
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

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