psnGPCR

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Orange: nodes, hubs and links specific of adrenergic_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of adrenergic_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	adrenergic_off Int. Strength	adrenergic_on Int. Strength	adrenergic_off Hub1?	adrenergic_on Hub1?	adrenergic_off Hub2?	adrenergic_on Hub2?	ConSurf1	ConSurf2
1	3x28	Lig	adrenergic_off	100	0	Yes	Yes	Yes	Yes	5	0
2	1x53	7x53	adrenergic_off	100	0	No	No	Yes	Yes	9	9
3	1x57	8x50	adrenergic_off	100	0	No	No	Yes	Yes	8	8
4	2x39	3x50	adrenergic_off	100	0	No	No	No	No	8	9
5	2x43	7x53	adrenergic_off	100	0	No	No	Yes	Yes	7	9
6	2x53	2x56	adrenergic_off	100	0	No	No	No	No	8	8
7	2x57	7x39	adrenergic_off	100	0	Yes	No	No	Yes	8	6
8	2x59	3x24	adrenergic_off	100	0	No	No	No	Yes	5	5
9	3x24	E1x50	adrenergic_off	100	0	No	Yes	Yes	Yes	5	8
10	3x37	4x57	adrenergic_off	100	0	Yes	No	No	No	7	8
11	3x39	6x44	adrenergic_off	100	0	No	No	Yes	Yes	9	9
12	3x41	4x53	adrenergic_off	100	0	Yes	No	No	No	6	8
13	3x41	5x50	adrenergic_off	100	0	Yes	No	Yes	No	6	9
14	3x43	6x41	adrenergic_off	100	0	No	No	No	No	8	8
15	3x43	6x44	adrenergic_off	100	0	No	No	Yes	Yes	8	9
16	3x49	3x50	adrenergic_off	100	0	Yes	Yes	No	No	9	9
17	5x51	6x45	adrenergic_off	100	0	No	No	No	No	6	5
18	5x54	6x41	adrenergic_off	100	0	No	No	No	No	8	8
19	5x58	5x61	adrenergic_off	100	0	Yes	Yes	No	No	9	9
20	5x58	I3	adrenergic_off	100	0	Yes	Yes	Yes	No	9	3
21	5x76	I3	adrenergic_off	100	0	No	No	Yes	No	2	3
22	I3	I3	adrenergic_off	100	0	Yes	No	Yes	No	3	3
23	6x40	7x52	adrenergic_off	100	0	No	No	No	No	8	8
24	6x54	E3	adrenergic_off	100	0	No	No	Yes	Yes	5	3
25	7x49	7x53	adrenergic_off	100	0	No	Yes	Yes	Yes	9	9
26	7x53	8x50	adrenergic_off	100	0	Yes	Yes	Yes	Yes	9	8
27	8x50	8x54	adrenergic_off	100	0	Yes	Yes	Yes	No	8	7
28	E2	NT	adrenergic_off	100	0	Yes	Yes	No	No	4	0
29	2x59	E1x52	adrenergic_off	100	0	No	No	Yes	No	5	5
30	2x62	E1x52	adrenergic_off	100	0	No	No	Yes	No	5	5
31	E1x49	E2	adrenergic_off	100	0	No	No	Yes	Yes	4	4
32	3x34	4x50	adrenergic_off	100	0	No	No	Yes	Yes	6	9
33	3x50	6x34	adrenergic_off	100	0	No	No	No	No	9	0
34	4x58	4x60	adrenergic_off	100	0	No	No	Yes	No	4	7
35	5x39	E2x52	adrenergic_off	100	0	Yes	Yes	Yes	No	8	6
36	6x40	7x49	adrenergic_off	100	0	No	No	No	Yes	8	9
37	6x44	7x45	adrenergic_off	100	0	Yes	Yes	No	No	9	9
38	6x36	7x55	adrenergic_off	100	0	No	No	No	No	0	5
39	6x30	I2x53	adrenergic_off	100	0	No	Yes	Yes	Yes	0	7
40	I2x52	I2x53	adrenergic_off	100	0	No	No	Yes	Yes	5	7
41	6x26	6x35	adrenergic_off	100	0	No	No	No	No	0	0
42	6x35	7x55	adrenergic_off	50	0	No	No	No	No	0	5
43	4x59	4x60	adrenergic_off	57.7381	0	No	No	Yes	No	7	7
44	1x46	7x46	adrenergic_off	50	0	No	No	No	No	8	9
45	5x58	5x62	adrenergic_off	75	0	Yes	Yes	No	No	9	5
46	8x49	I1x50	adrenergic_off	50	0	Yes	No	No	No	7	8
47	3x46	6x37	adrenergic_off	57.1429	0	No	No	No	No	9	0
48	4x41	I2x56	adrenergic_off	54.1667	0	No	No	No	No	6	5
49	5x67	5x68	adrenergic_off	75	0	No	No	No	No	5	7
50	5x72	I3	adrenergic_off	50	0	No	No	Yes	No	6	3
51	5x65	6x31	adrenergic_off	50	0	No	No	Yes	No	8	0
52	1x53	2x47	adrenergic_off	32.7381	0	No	No	No	No	9	9
53	2x66	E1x51	adrenergic_off	50	0	No	No	No	No	5	3
54	2x64	NT	adrenergic_off	50	0	No	No	No	No	5	0
55	6x58	6x62	adrenergic_off	50	0	No	No	No	No	4	0
56	2x41	4x39	adrenergic_off	50	0	No	No	No	No	5	4
57	3x23	3x27	adrenergic_off	36.9048	0	No	No	No	No	3	5
58	6x57	E3	adrenergic_off	53.5714	0	No	No	Yes	Yes	5	3
59	8x48	8x49	adrenergic_off	50	0	No	No	Yes	No	5	7
60	1x47	2x51	adrenergic_off	39.2857	0	No	No	No	No	6	7
61	5x37	E3	adrenergic_off	50	0	No	No	Yes	Yes	4	3
62	5x41	6x60	adrenergic_off	54.1667	0	No	No	No	No	6	5
63	7x30	7x33	adrenergic_off	50	0	No	No	No	No	5	5
64	2x38	I2x55	adrenergic_off	50	0	No	No	No	No	7	4
65	5x71	I3	adrenergic_off	58.3333	0	No	No	Yes	No	4	3
66	6x28	6x31	adrenergic_off	50	0	No	No	Yes	No	0	0
67	3x30	4x62	adrenergic_off	50	0	No	No	No	No	6	4
68	6x47	7x40	adrenergic_off	28.5714	0	No	No	No	No	8	7
69	6x29	8x49	adrenergic_off	50	0	No	No	Yes	No	0	7
70	1x42	2x57	adrenergic_off	50	0	No	No	Yes	No	7	8
71	3x49	I2x55	adrenergic_off	50	0	Yes	Yes	No	No	9	4
72	5x58	6x38	adrenergic_off	32.1429	0	Yes	Yes	No	No	9	0
73	3x55	3x56	adrenergic_off	37.5	0	No	No	No	No	7	6
74	3x21	E1x50	adrenergic_off	0	0	No	No	Yes	Yes	8	8
75	2x61	2x65	adrenergic_off	50	0	No	No	Yes	Yes	6	5
76	6x31	I2x53	adrenergic_off	50	0	Yes	No	Yes	Yes	0	7
77	5x71	5x74	adrenergic_off	50	0	No	No	No	No	4	4
78	6x33	6x37	adrenergic_off	50	0	No	No	No	No	0	0
79	4x60	5x42	adrenergic_off	50	0	Yes	No	No	No	7	5
80	1x59	1x60	adrenergic_off	25	0	No	No	Yes	No	5	6
81	7x31	7x35	adrenergic_off	25	0	No	No	No	No	2	5
82	8x56	CT	adrenergic_off	25	0	No	No	No	No	5	7
83	5x69	6x31	adrenergic_off	37.5	0	No	Yes	Yes	No	5	0
84	1x33	1x34	adrenergic_off	25	0	No	No	No	No	6	4
85	I2x54	I2x57	adrenergic_off	25	0	No	No	Yes	Yes	6	6
86	5x45	5x49	adrenergic_off	0	0	No	No	No	No	4	5
87	I1x48	I1x49	adrenergic_off	3.57143	0	No	No	No	No	7	6
88	5x51	5x55	adrenergic_off	25	0	No	No	No	No	6	5
89	4x41	I2x57	adrenergic_off	29.1667	0	No	No	Yes	Yes	6	6
90	6x29	6x32	adrenergic_off	4.16667	0	No	No	No	No	0	0
91	5x66	6x25	adrenergic_off	25	0	No	No	No	No	5	0
92	2x50	Na1	adrenergic_off	25	0	Yes	Yes	No	No	9	0
93	5x68	6x27	adrenergic_off	25	0	No	No	No	No	7	0
94	5x72	6x24	adrenergic_off	25	0	No	No	No	No	6	0
95	6x42	6x45	adrenergic_off	8.33333	0	No	No	No	No	5	5
96	1x45	7x51	adrenergic_off	0	0	No	No	No	No	5	6
97	5x70	I3	adrenergic_off	25	0	No	No	Yes	No	5	3
98	I2x51	I2x52	adrenergic_off	4.16667	0	No	No	No	No	7	5
99	1x30	1x33	adrenergic_off	25	0	No	No	No	No	4	6
100	1x33	1x37	adrenergic_off	0	0	No	No	No	No	6	5
101	1x44	1x48	adrenergic_off	3.57143	0	No	No	No	No	4	4
102	1x38	1x42	adrenergic_off	0	0	No	No	No	No	5	7
103	2x67	E1x49	adrenergic_off	0	0	No	No	No	No	4	4
104	6x23	I3	adrenergic_off	8.33333	0	No	No	Yes	No	0	3
105	6x21	6x22	adrenergic_off	8.33333	0	No	No	No	No	0	0
106	1x37	1x41	adrenergic_off	3.57143	0	No	No	No	No	5	5
107	1x28	1x31	adrenergic_off	0	0	No	No	No	Yes	0	3
108	6x20	6x22	adrenergic_off	4.16667	0	No	No	No	No	0	0
109	5x68	6x20	adrenergic_off	4.16667	0	No	No	No	No	7	0
110	1x40	1x41	adrenergic_off	0	0	No	No	No	No	3	5
111	5x73	6x24	adrenergic_off	8.33333	0	No	No	No	No	4	0
112	1x28	1x29	adrenergic_off	3.57143	0	No	No	No	No	0	0
113	4x43	4x47	adrenergic_off	0	0	No	No	No	No	5	4
114	1x26	1x29	adrenergic_off	4.16667	0	No	No	No	No	0	0
115	1x25	1x28	adrenergic_off	4.16667	0	No	No	No	No	0	0
116	1x27	1x30	adrenergic_off	0	0	No	No	No	No	0	4
117	8x55	8x60	adrenergic_off	4.16667	0	No	No	No	No	5	0
118	3x32	Lig	Shared	100	100	No	No	Yes	Yes	7	0
119	3x33	Lig	Shared	100	100	No	No	Yes	Yes	6	0
120	3x36	Lig	Shared	100	100	No	No	Yes	Yes	6	0
121	5x43	Lig	Shared	100	100	No	No	Yes	Yes	7	0
122	5x461	Lig	Shared	100	100	No	No	Yes	Yes	6	0
123	6x51	Lig	Shared	100	100	Yes	Yes	Yes	Yes	7	0
124	6x52	Lig	Shared	100	100	Yes	Yes	Yes	Yes	7	0
125	6x55	Lig	Shared	100	100	No	Yes	Yes	Yes	7	0
126	7x38	Lig	Shared	100	100	No	No	Yes	Yes	6	0
127	7x42	Lig	Shared	100	100	Yes	Yes	Yes	Yes	7	0
128	1x39	2x61	Shared	100	100	No	No	No	No	7	6
129	1x39	7x39	Shared	100	100	No	No	No	Yes	7	6
130	1x43	2x57	Shared	100	100	No	No	Yes	No	5	8
131	1x49	7x50	Shared	100	51.3889	No	No	No	No	9	9
132	1x50	2x50	Shared	100	100	No	Yes	Yes	Yes	9	9
133	1x50	7x50	Shared	100	100	No	Yes	No	No	9	9
134	1x52	8x54	Shared	100	100	No	No	Yes	No	7	7
135	1x57	2x40	Shared	100	100	No	No	No	Yes	8	8
136	1x57	2x44	Shared	100	100	No	No	No	No	8	6
137	1x60	I1x50	Shared	100	100	Yes	No	No	No	6	8
138	1x60	8x53	Shared	100	26.3889	Yes	No	No	No	6	7
139	8x49	I1x49	Shared	100	100	Yes	No	No	No	7	6
140	2x37	2x40	Shared	100	100	No	No	No	Yes	7	8
141	2x39	3x49	Shared	100	100	No	No	Yes	Yes	8	9
142	2x42	3x45	Shared	100	100	Yes	Yes	No	No	8	7
143	2x42	3x46	Shared	100	100	Yes	Yes	No	No	8	9
144	2x42	3x49	Shared	100	100	Yes	Yes	Yes	Yes	8	9
145	2x42	4x46	Shared	100	100	Yes	Yes	No	No	8	8
146	2x45	4x46	Shared	100	100	No	No	No	No	9	8
147	2x45	4x50	Shared	100	100	No	No	Yes	Yes	9	9
148	2x46	3x43	Shared	100	100	No	Yes	No	No	9	8
149	2x50	3x39	Shared	100	100	Yes	Yes	No	No	9	9
150	2x53	3x35	Shared	100	100	No	No	No	No	8	6
151	2x53	7x46	Shared	100	100	No	No	No	No	8	9
152	2x56	3x28	Shared	100	100	No	No	Yes	Yes	8	5
153	2x56	3x32	Shared	100	100	No	No	No	No	8	7
154	2x57	7x42	Shared	100	62.5	Yes	No	Yes	Yes	8	7
155	2x59	3x28	Shared	100	100	No	No	Yes	Yes	5	5
156	2x63	E1x50	Shared	100	100	No	No	Yes	Yes	4	8
157	2x64	7x35	Shared	100	100	No	No	No	No	5	5
158	E1x49	E1x51	Shared	100	100	No	No	No	No	4	3
159	E1x50	E1x52	Shared	100	100	Yes	Yes	Yes	No	8	5
160	3x25	E1x50	Shared	100	100	No	No	Yes	Yes	9	8
161	3x28	E1x50	Shared	100	100	Yes	Yes	Yes	Yes	5	8
162	E1x50	E2x50	Shared	100	100	Yes	Yes	No	No	8	9
163	3x22	E2	Shared	100	50	No	No	Yes	Yes	5	4
164	3x25	E2x50	Shared	100	100	No	No	No	No	9	9
165	3x30	4x61	Shared	100	100	No	No	No	No	6	5
166	3x31	3x35	Shared	100	100	No	No	No	No	5	6
167	3x32	7x42	Shared	100	100	No	No	Yes	Yes	7	7
168	3x33	4x57	Shared	100	100	No	No	No	No	6	8
169	3x34	4x57	Shared	100	100	No	No	No	No	6	8
170	3x36	6x48	Shared	100	100	No	No	Yes	Yes	6	8
171	3x37	4x53	Shared	100	100	Yes	No	No	No	7	8
172	3x37	5x461	Shared	100	100	Yes	No	No	No	7	6
173	3x38	4x50	Shared	100	100	No	No	Yes	Yes	8	9
174	3x38	4x53	Shared	100	100	No	No	No	No	8	8
175	3x40	5x50	Shared	100	100	No	No	Yes	No	8	9
176	3x40	6x44	Shared	100	100	No	No	Yes	Yes	8	9
177	3x41	4x52	Shared	100	16.6667	Yes	No	No	No	6	5
178	3x44	5x53	Shared	100	100	No	No	No	No	6	6
179	3x48	3x52	Shared	100	100	No	No	No	No	6	5
180	3x49	I2x53	Shared	100	100	Yes	Yes	Yes	Yes	9	7
181	3x49	I2x57	Shared	100	100	Yes	Yes	Yes	Yes	9	6
182	3x51	3x55	Shared	100	100	Yes	Yes	No	No	8	7
183	3x51	5x57	Shared	100	100	Yes	Yes	No	No	8	6
184	3x53	I2x53	Shared	100	100	No	No	Yes	Yes	8	7
185	I2x53	I2x57	Shared	100	100	Yes	Yes	Yes	Yes	7	6
186	4x38	4x41	Shared	100	54.1667	No	No	No	No	7	6
187	E2	E2	Shared	100	100	Yes	Yes	Yes	Yes	4	4
188	5x36	E2	Shared	100	100	No	No	Yes	Yes	6	4
189	E2	E2x52	Shared	100	100	Yes	Yes	Yes	No	4	6
190	5x39	E2	Shared	100	100	Yes	Yes	Yes	Yes	8	4
191	5x39	5x43	Shared	100	100	Yes	Yes	No	No	8	7
192	5x40	6x55	Shared	100	100	No	No	No	Yes	6	7
193	5x40	6x59	Shared	100	8.33333	No	No	No	No	6	5
194	5x44	6x52	Shared	100	100	No	No	Yes	Yes	7	7
195	5x47	5x48	Shared	100	100	Yes	Yes	No	No	8	6
196	5x47	5x51	Shared	100	100	Yes	Yes	No	No	8	6
197	5x47	6x52	Shared	100	100	Yes	Yes	Yes	Yes	8	7
198	6x39	7x52	Shared	100	20.8333	No	No	No	No	7	8
199	6x40	7x53	Shared	100	100	No	No	Yes	Yes	8	9
200	6x43	7x52	Shared	100	100	No	No	No	No	7	8
201	6x44	6x48	Shared	100	100	Yes	Yes	Yes	Yes	9	8
202	6x47	7x45	Shared	100	100	No	No	No	No	8	9
203	6x48	6x51	Shared	100	100	Yes	Yes	Yes	Yes	8	7
204	6x48	6x52	Shared	100	100	Yes	Yes	Yes	Yes	8	7
205	6x48	7x41	Shared	100	100	Yes	Yes	No	No	8	7
206	6x51	6x52	Shared	100	100	Yes	Yes	Yes	Yes	7	7
207	6x51	6x55	Shared	100	100	Yes	Yes	No	Yes	7	7
208	6x51	7x34	Shared	100	100	Yes	Yes	No	No	7	4
209	6x51	7x38	Shared	100	100	Yes	Yes	No	No	7	6
210	6x61	E3	Shared	100	100	No	No	Yes	Yes	4	3
211	E3	E3	Shared	100	100	Yes	Yes	Yes	Yes	3	3
212	7x30	7x32	Shared	100	50	No	No	No	No	5	1
213	7x38	7x42	Shared	100	100	No	No	Yes	Yes	6	7
214	7x39	7x42	Shared	100	100	No	Yes	Yes	Yes	6	7
215	7x54	8x54	Shared	100	100	No	No	Yes	No	7	7
216	8x47	8x50	Shared	100	100	No	No	Yes	Yes	8	8
217	8x48	8x51	Shared	100	8.33333	No	No	No	No	5	8
218	E2x52	Lig	Shared	100	100	Yes	No	Yes	Yes	6	0
219	8x50	I1x50	Shared	100	100	Yes	Yes	No	No	8	8
220	2x39	I2x57	Shared	100	100	No	No	Yes	Yes	8	6
221	2x45	3x42	Shared	100	100	No	No	No	Yes	9	7
222	2x50	7x46	Shared	100	100	Yes	Yes	No	No	9	9
223	2x52	3x35	Shared	100	100	No	No	No	No	6	6
224	E1x51	E1x52	Shared	100	100	No	No	Yes	No	3	5
225	3x24	3x27	Shared	100	25	No	Yes	No	No	5	5
226	3x29	E2x52	Shared	100	43.0556	No	No	Yes	No	6	6
227	3x51	5x60	Shared	100	100	Yes	Yes	No	No	8	6
228	5x48	6x56	Shared	100	100	No	No	No	No	6	6
229	5x58	6x41	Shared	100	100	Yes	Yes	No	No	9	8
230	6x49	6x53	Shared	100	100	No	Yes	No	No	7	6
231	6x50	7x37	Shared	100	100	No	No	No	Yes	9	5
232	6x58	E3	Shared	100	100	No	No	Yes	Yes	4	3
233	7x33	7x37	Shared	100	100	No	No	No	Yes	5	5
234	1x31	1x35	Shared	100	16.6667	No	Yes	No	No	3	5
235	3x26	4x64	Shared	100	50	No	No	No	No	6	6
236	3x30	4x58	Shared	100	100	No	No	No	No	6	4
237	4x63	E2	Shared	100	50	No	No	Yes	Yes	5	4
238	4x64	E2	Shared	100	100	No	No	Yes	Yes	6	4
239	E2	E2x51	Shared	100	100	Yes	Yes	No	No	4	5
240	5x64	5x67	Shared	100	13.8889	No	No	No	No	6	5
241	2x60	3x28	Shared	75	100	No	No	Yes	Yes	7	5
242	1x51	2x51	Shared	69.0476	58.3333	No	No	No	No	4	7
243	3x52	I2x53	Shared	50	100	No	No	Yes	Yes	5	7
244	3x47	5x57	Shared	54.1667	100	No	No	No	No	9	6
245	6x54	7x37	Shared	50	100	No	No	No	Yes	5	5
246	5x47	6x49	Shared	61.9048	100	Yes	Yes	No	Yes	8	7
247	1x60	8x56	Shared	75	100	Yes	No	No	No	6	5
248	2x50	7x49	Shared	75	100	Yes	Yes	No	Yes	9	9
249	3x41	4x49	Shared	75	100	Yes	No	No	No	6	6
250	2x42	4x42	Shared	54.1667	100	Yes	Yes	No	No	8	7
251	2x41	4x43	Shared	50	25	No	No	No	No	5	5
252	1x46	2x54	Shared	50	100	No	No	No	No	8	7
253	5x36	5x38	Shared	50	100	No	No	No	No	6	5
254	1x56	8x54	Shared	54.1667	25	No	No	Yes	No	8	7
255	1x43	2x58	Shared	75	100	No	No	No	No	5	9
256	3x51	5x61	Shared	50	8.33333	Yes	Yes	No	No	8	9
257	1x46	7x47	Shared	36.9048	100	No	No	No	No	8	6
258	3x54	5x61	Shared	61.3095	5.55556	No	No	No	No	8	9
259	2x42	4x45	Shared	50	100	Yes	Yes	No	No	8	6
260	3x54	5x64	Shared	50	30.5556	No	No	No	No	8	6
261	4x60	5x39	Shared	50	100	Yes	No	Yes	Yes	7	8
262	1x32	2x65	Shared	28.5714	13.8889	No	No	Yes	Yes	4	5
263	1x54	2x47	Shared	29.1667	83.3333	No	No	No	No	7	9
264	1x52	8x58	Shared	37.5	29.1667	No	No	No	No	7	7
265	5x41	6x59	Shared	50	37.5	No	No	No	No	6	5
266	5x49	5x50	Shared	50	20.8333	No	No	Yes	No	5	9
267	5x60	5x63	Shared	50	41.6667	No	No	No	No	6	4
268	1x47	2x55	Shared	50	5.55556	No	No	No	No	6	5
269	2x38	4x39	Shared	58.3333	100	No	No	No	No	7	4
270	1x55	8x57	Shared	29.1667	66.6667	No	No	No	No	4	6
271	6x35	6x39	Shared	37.5	100	No	No	No	No	0	7
272	1x52	8x57	Shared	7.14286	38.8889	No	No	No	No	7	6
273	5x56	5x60	Shared	50	29.1667	No	No	No	No	4	6
274	5x37	6x59	Shared	50	50	No	No	No	No	4	5
275	7x55	7x56	Shared	50	50	No	No	No	No	5	7
276	1x42	7x43	Shared	57.1429	20.8333	No	No	No	No	7	5
277	2x55	2x551	Shared	50	55.5556	No	No	No	No	5	6
278	7x36	7x40	Shared	50	100	No	No	No	No	5	7
279	3x44	5x50	Shared	25	72.2222	No	No	Yes	No	6	9
280	1x45	7x47	Shared	29.1667	58.3333	No	No	No	No	5	6
281	6x43	7x48	Shared	8.33333	26.3889	No	No	No	No	7	6
282	4x56	5x46	Shared	25	50	No	No	No	No	6	5
283	2x49	4x50	Shared	0	12.5	No	No	Yes	Yes	8	9
284	8x48	8x52	Shared	25	25	No	No	No	No	5	5
285	I1x48	I1x51	Shared	12.5	100	No	No	No	No	7	8
286	8x58	8x59	Shared	50	8.33333	No	No	No	No	7	5
287	3x37	4x56	Shared	0	100	Yes	No	No	No	7	6
288	8x51	8x55	Shared	4.16667	22.2222	No	No	No	No	8	5
289	1x50	2x51	Shared	0	41.6667	No	Yes	No	No	9	7
290	3x56	I2x50	Shared	10.7143	0	No	No	No	No	6	8
291	1x35	2x65	Shared	0	16.6667	No	No	Yes	Yes	5	5
292	3x34	4x54	Shared	0	0	No	No	No	No	6	4
293	1x48	1x49	Shared	7.14286	20.8333	No	No	No	No	4	9
294	1x36	2x65	Shared	12.5	33.3333	No	No	Yes	Yes	6	5
295	4x38	4x40	Shared	0	8.33333	No	No	No	No	7	5
296	5x62	5x66	Shared	25	100	No	No	No	No	5	5
297	4x40	4x44	Shared	25	5.55556	No	No	No	No	5	3
298	1x54	2x48	Shared	3.57143	16.6667	No	No	No	No	7	6
299	4x48	4x52	Shared	0	8.33333	No	No	No	No	2	5
300	4x47	4x51	Shared	3.57143	0	No	No	No	No	4	4
301	4x55	4x59	Shared	14.881	8.33333	No	No	No	No	4	7
302	1x54	1x58	Shared	0	33.3333	No	No	No	No	7	2
303	5x52	5x56	Shared	0	8.33333	No	No	No	No	4	4
304	5x55	5x59	Shared	0	0	No	No	No	No	5	3
305	1x41	1x45	Shared	0	12.5	No	No	No	No	5	5
306	1x46	1x50	adrenergic_on	0	100	No	No	No	Yes	8	9
307	1x50	2x47	adrenergic_on	0	100	No	Yes	No	No	9	9
308	2x40	I1x50	adrenergic_on	0	100	No	Yes	No	No	8	8
309	2x40	8x50	adrenergic_on	0	100	No	Yes	Yes	Yes	8	8
310	2x41	4x42	adrenergic_on	0	100	No	No	No	No	5	7
311	2x46	3x42	adrenergic_on	0	100	No	Yes	No	Yes	9	7
312	2x46	7x49	adrenergic_on	0	100	No	Yes	No	Yes	9	9
313	2x56	7x42	adrenergic_on	0	100	No	No	Yes	Yes	8	7
314	2x57	2x58	adrenergic_on	0	100	Yes	No	No	No	8	9
315	3x24	E1x52	adrenergic_on	0	100	No	Yes	Yes	No	5	5
316	3x40	6x48	adrenergic_on	0	100	No	No	Yes	Yes	8	8
317	3x42	4x49	adrenergic_on	0	100	No	Yes	No	No	7	6
318	3x43	7x49	adrenergic_on	0	100	No	No	No	Yes	8	9
319	3x43	7x53	adrenergic_on	0	100	No	No	Yes	Yes	8	9
320	3x46	3x50	adrenergic_on	0	100	No	No	No	No	9	9
321	3x47	5x58	adrenergic_on	0	100	No	No	Yes	Yes	9	9
322	5x54	5x58	adrenergic_on	0	100	No	No	Yes	Yes	8	9
323	6x36	7x56	adrenergic_on	0	100	No	No	No	No	0	7
324	6x48	7x45	adrenergic_on	0	100	Yes	Yes	No	No	8	9
325	6x49	6x50	adrenergic_on	0	100	No	Yes	No	No	7	9
326	6x54	7x34	adrenergic_on	0	100	No	No	No	No	5	4
327	7x45	7x49	adrenergic_on	0	100	No	No	No	Yes	9	9
328	7x52	7x53	adrenergic_on	0	100	No	No	Yes	Yes	8	9
329	7x54	8x50	adrenergic_on	0	100	No	No	Yes	Yes	7	8
330	8x47	8x49	adrenergic_on	0	100	No	No	Yes	No	8	7
331	2x46	2x50	adrenergic_on	0	100	No	Yes	Yes	Yes	9	9
332	3x42	4x50	adrenergic_on	0	100	No	Yes	Yes	Yes	7	9
333	3x46	7x53	adrenergic_on	0	100	No	No	Yes	Yes	9	9
334	3x50	5x58	adrenergic_on	0	100	No	No	Yes	Yes	9	9
335	3x50	7x53	adrenergic_on	0	100	No	No	Yes	Yes	9	9
336	3x51	3x52	adrenergic_on	0	100	Yes	Yes	No	No	8	5
337	3x56	I2x52	adrenergic_on	0	100	No	No	No	No	6	5
338	5x44	6x56	adrenergic_on	0	100	No	No	No	No	7	6
339	5x47	6x44	adrenergic_on	0	100	Yes	Yes	Yes	Yes	8	9
340	5x47	6x48	adrenergic_on	0	100	Yes	Yes	Yes	Yes	8	8
341	5x51	6x44	adrenergic_on	0	100	No	No	Yes	Yes	6	9
342	5x54	6x44	adrenergic_on	0	100	No	No	Yes	Yes	8	9
343	5x58	6x37	adrenergic_on	0	100	Yes	Yes	No	No	9	0
344	5x58	6x40	adrenergic_on	0	100	Yes	Yes	No	No	9	8
345	5x62	6x34	adrenergic_on	0	100	No	No	No	No	5	0
346	5x62	6x37	adrenergic_on	0	100	No	No	No	No	5	0
347	1x53	7x54	adrenergic_on	0	100	No	No	No	No	9	7
348	4x59	5x39	adrenergic_on	0	100	No	No	Yes	Yes	7	8
349	5x44	6x55	adrenergic_on	0	100	No	No	No	Yes	7	7
350	5x69	6x26	adrenergic_on	0	100	No	Yes	No	No	5	0
351	3x21	3x24	adrenergic_on	0	100	No	No	No	Yes	8	5
352	3x56	I2x53	adrenergic_on	0	100	No	No	Yes	Yes	6	7
353	4x58	4x62	adrenergic_on	0	100	No	No	No	No	4	4
354	6x45	6x49	adrenergic_on	0	34.7222	No	No	No	Yes	5	7
355	4x58	4x59	adrenergic_on	0	50	No	No	No	No	4	7
356	2x37	2x39	adrenergic_on	0	66.6667	No	No	No	No	7	8
357	5x65	6x33	adrenergic_on	0	50	No	No	No	No	8	0
358	2x66	E1x49	adrenergic_on	0	66.6667	No	No	No	No	5	4
359	6x53	6x57	adrenergic_on	0	50	No	No	No	No	6	5
360	5x66	6x30	adrenergic_on	0	41.6667	No	No	No	Yes	5	0
361	6x58	7x34	adrenergic_on	0	54.1667	No	No	No	No	4	4
362	5x37	6x60	adrenergic_on	0	75	No	No	No	No	4	5
363	5x55	6x41	adrenergic_on	0	58.3333	No	No	No	No	5	8
364	7x30	E3	adrenergic_on	0	50	No	No	Yes	Yes	5	3
365	6x30	6x33	adrenergic_on	0	50	No	Yes	No	No	0	0
366	2x64	7x39	adrenergic_on	0	41.6667	No	No	No	Yes	5	6
367	1x42	7x39	adrenergic_on	0	50	No	No	No	Yes	7	6
368	2x551	3x31	adrenergic_on	0	47.2222	No	No	No	No	6	5
369	8x47	8x48	adrenergic_on	0	50	No	No	No	No	8	5
370	5x45	5x48	adrenergic_on	0	50	No	No	No	No	4	6
371	5x69	6x29	adrenergic_on	0	33.3333	No	Yes	No	No	5	0
372	2x43	8x50	adrenergic_on	0	58.3333	No	No	Yes	Yes	7	8
373	1x36	2x61	adrenergic_on	0	50	No	No	No	No	6	6
374	2x38	I2x57	adrenergic_on	0	20.8333	No	No	Yes	Yes	7	6
375	7x55	8x51	adrenergic_on	0	25	No	No	No	No	5	8
376	7x36	7x37	adrenergic_on	0	16.6667	No	No	No	Yes	5	5
377	1x55	1x59	adrenergic_on	0	41.6667	No	No	No	No	4	5
378	4x38	4x39	adrenergic_on	0	25	No	No	No	No	7	4
379	I2x52	I2x56	adrenergic_on	0	12.5	No	No	No	No	5	5
380	5x67	5x71	adrenergic_on	0	16.6667	No	No	No	No	5	4
381	5x69	6x30	adrenergic_on	0	16.6667	No	Yes	No	Yes	5	0
382	2x62	E1x51	adrenergic_on	0	5.55556	No	No	No	No	5	3
383	3x23	3x24	adrenergic_on	0	18.0556	No	No	No	Yes	3	5
384	6x41	6x42	adrenergic_on	0	0	No	No	No	No	8	5
385	6x31	6x35	adrenergic_on	0	22.2222	Yes	No	No	No	0	0
386	1x29	1x31	adrenergic_on	0	20.8333	No	No	No	Yes	0	3
387	6x27	6x30	adrenergic_on	0	16.6667	No	No	No	Yes	0	0
388	5x75	I3	adrenergic_on	0	16.6667	No	No	Yes	No	2	3
389	5x73	I3	adrenergic_on	0	16.6667	No	No	Yes	No	4	3
390	7x31	7x32	adrenergic_on	0	20.8333	No	No	No	No	2	1
391	5x74	5x75	adrenergic_on	0	16.6667	No	No	No	No	4	2
392	5x68	5x71	adrenergic_on	0	8.33333	No	No	No	No	7	4
393	7x51	7x55	adrenergic_on	0	8.33333	No	No	No	No	6	5
394	1x31	1x34	adrenergic_on	0	12.5	No	Yes	No	No	3	4
395	I2x55	I2x56	adrenergic_on	0	8.33333	No	No	No	No	4	5
396	I2x50	I2x51	adrenergic_on	0	16.6667	No	No	No	No	8	7
397	6x32	6x36	adrenergic_on	0	4.16667	No	No	No	No	0	0
398	6x28	6x32	adrenergic_on	0	8.33333	No	No	No	No	0	0
399	1x57	I1x51	adrenergic_on	0	16.6667	No	No	No	No	8	8
400	1x40	1x43	adrenergic_on	0	8.33333	No	No	No	No	3	5
401	1x35	1x38	adrenergic_on	0	12.5	No	No	No	No	5	5
402	5x69	5x73	adrenergic_on	0	16.6667	No	Yes	No	No	5	4
403	I2x53	I2x54	adrenergic_on	0	5.55556	Yes	Yes	No	No	7	6
404	1x44	1x47	adrenergic_on	0	0	No	No	No	No	4	6
405	1x30	1x31	adrenergic_on	0	12.5	No	No	No	Yes	4	3
406	5x72	5x76	adrenergic_on	0	0	No	No	No	No	6	2
407	5x72	6x29	adrenergic_on	0	8.33333	No	No	No	No	6	0
408	5x70	5x71	adrenergic_on	0	8.33333	No	No	No	No	5	4
409	6x46	6x47	adrenergic_on	0	4.16667	No	No	No	No	5	8
410	2x66	2x67	adrenergic_on	0	0	No	No	No	No	5	4
411	1x33	2x65	adrenergic_on	0	0	No	No	Yes	Yes	6	5
412	8x59	CT	adrenergic_on	0	0	No	No	No	No	5	7
413	4x51	4x55	adrenergic_on	0	0	No	No	No	No	4	4
414	6x37	6x38	adrenergic_on	0	0	No	No	No	No	0	0
415	5x38	5x42	adrenergic_on	0	4.16667	No	No	No	No	5	5
416	1x31	NT	adrenergic_on	0	4.16667	No	Yes	No	No	3	0
417	6x24	6x25	adrenergic_on	0	0	No	No	No	No	0	0
418	1x34	1x37	adrenergic_on	0	0	No	No	No	No	4	5
419	6x25	6x28	adrenergic_on	0	0	No	No	No	No	0	0

Orange: nodes, hubs and links specific of adrenergic_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of adrenergic_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	adrenergic_off Avg Int. Strength	adrenergic_on Avg Int. Strength	adrenergic_off Num Of Links	adrenergic_on Num Of Links	ConSurf
1	1x60	adrenergic_off	0	0	4	3	6
2	2x57	adrenergic_off	0	0	4	3	8
3	E1x52	adrenergic_off	42.8571	0	4	3	5
4	3x37	adrenergic_off	0	0	4	3	7
5	3x41	adrenergic_off	0	0	4	2	6
6	4x60	adrenergic_off	0	0	4	1	7
7	E2x52	adrenergic_off	25	0	4	3	6
8	5x50	adrenergic_off	0	0	4	3	9
9	I3	adrenergic_off	25	0	8	2	3
10	8x49	adrenergic_off	25	0	4	2	7
11	8x54	adrenergic_off	0	0	4	3	7
12	6x31	adrenergic_off	0	0	4	1	0
13	Lig	Shared	100	100	12	11	0
14	2x42	Shared	64.2857	56.9444	6	6	8
15	2x50	Shared	0	69.4444	5	5	9
16	2x65	Shared	0	0	4	4	5
17	E1x50	Shared	100	91.6667	7	5	8
18	3x28	Shared	25	41.6667	5	4	5
19	3x49	Shared	55.9524	4.16667	6	4	9
20	3x51	Shared	0	41.6667	4	5	8
21	I2x53	Shared	25	25	7	6	7
22	I2x57	Shared	25	45.8333	5	4	6
23	4x50	Shared	0	0	4	4	9
24	E2	Shared	100	50	11	9	4
25	5x39	Shared	0	25	4	4	8
26	5x47	Shared	25	95.8333	4	6	8
27	5x58	Shared	0	95.8333	5	6	9
28	6x44	Shared	100	56.9444	5	5	9
29	6x48	Shared	96.4286	100	5	8	8
30	6x51	Shared	96.4286	95.8333	6	6	7
31	6x52	Shared	96.4286	70.8333	5	5	7
32	E3	Shared	67.2619	50	7	5	3
33	7x42	Shared	100	95.8333	5	6	7
34	7x53	Shared	45.8333	65.2778	5	5	9
35	8x50	Shared	100	75	5	5	8
36	1x31	adrenergic_on	0	0	2	5	3
37	1x50	adrenergic_on	0	45.8333	3	5	9
38	2x40	adrenergic_on	0	8.33333	2	4	8
39	2x46	adrenergic_on	0	22.2222	1	4	9
40	3x24	adrenergic_on	25	0	3	4	5
41	3x42	adrenergic_on	0	50	1	4	7
42	5x69	adrenergic_on	0	0	1	4	5
43	6x30	adrenergic_on	0	0	1	4	0
44	6x49	adrenergic_on	0	0	2	4	7
45	6x55	adrenergic_on	0	29.1667	3	4	7
46	7x37	adrenergic_on	0	0	3	4	5
47	7x39	adrenergic_on	0	0	3	4	6
48	7x49	adrenergic_on	0	50	3	4	9

Orange: nodes, hubs and links specific of adrenergic_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of adrenergic_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	adrenergic_off Recurrence	adrenergic_on Recurrence	adrenergic_off Hub1?	adrenergic_on Hub1?	adrenergic_off Hub2?	adrenergic_on Hub2?	ConSurf1	ConSurf2
1	3x28	Lig	adrenergic_off	44.3307	0	Yes	Yes	Yes	Yes	5	0
2	3x33	Lig	adrenergic_off	34.4067	7.23334	No	No	Yes	Yes	6	0
3	2x57	7x42	adrenergic_off	10.8534	8.75203	Yes	No	Yes	Yes	8	7
4	2x53	2x56	adrenergic_off	52.2805	0	No	No	No	No	8	8
5	7x49	7x53	adrenergic_off	63.4547	0	No	Yes	Yes	Yes	9	9
6	7x53	8x50	adrenergic_off	53.831	0	Yes	Yes	Yes	Yes	9	8
7	8x50	8x54	adrenergic_off	14.9949	0	Yes	Yes	Yes	No	8	7
8	8x50	I1x50	adrenergic_off	30.3804	0.207093	Yes	Yes	No	No	8	8
9	8x49	I1x50	adrenergic_off	19.7203	0	Yes	No	No	No	7	8
10	3x34	4x50	adrenergic_off	26.1567	0	No	No	Yes	Yes	6	9
11	3x34	4x57	adrenergic_off	30.7053	3.74447	No	No	No	No	6	8
12	3x33	4x57	adrenergic_off	32.2106	5.61205	No	No	No	No	6	8
13	3x43	6x44	adrenergic_off	63.4423	0	No	No	Yes	Yes	8	9
14	3x39	6x44	adrenergic_off	69.1425	0	No	No	Yes	Yes	9	9
15	2x50	3x39	adrenergic_off	67.8511	1.42913	Yes	Yes	No	No	9	9
16	2x59	3x28	adrenergic_off	12.7658	4.05418	No	No	Yes	Yes	5	5
17	4x60	5x39	adrenergic_off	41.6492	1.87317	Yes	No	Yes	Yes	7	8
18	4x58	4x60	adrenergic_off	20.8883	0	No	No	Yes	No	4	7
19	3x30	4x58	adrenergic_off	15.6776	3.74447	No	No	No	No	6	4
20	5x39	E2x52	adrenergic_off	22.48	0	Yes	Yes	Yes	No	8	6
21	3x40	6x44	adrenergic_off	31.1577	1.35077	No	No	Yes	Yes	8	9
22	3x40	5x50	adrenergic_off	29.6484	4.16239	No	No	Yes	No	8	9
23	3x41	4x53	adrenergic_off	24.3348	0	Yes	No	No	No	6	8
24	3x41	5x50	adrenergic_off	23.8083	0	Yes	No	Yes	No	6	9
25	3x43	6x41	adrenergic_off	59.9054	0	No	No	No	No	8	8
26	5x58	6x41	adrenergic_off	56.2698	5.35644	Yes	Yes	No	No	9	8
27	5x58	5x61	adrenergic_off	35.3856	0	Yes	Yes	No	No	9	9
28	3x51	5x61	adrenergic_off	20.2303	9.31547	Yes	Yes	No	No	8	9
29	6x55	Lig	adrenergic_off	12.6095	1.52428	No	Yes	Yes	Yes	7	0
30	5x40	6x55	adrenergic_off	20.3085	3.58029	No	No	No	Yes	6	7
31	5x40	6x59	adrenergic_off	19.0829	2.87132	No	No	No	No	6	5
32	6x40	7x49	adrenergic_off	15.9778	0	No	No	No	Yes	8	9
33	6x40	7x52	adrenergic_off	15.476	0	No	No	No	No	8	8
34	5x37	6x59	adrenergic_off	15.3568	1.44219	No	No	No	No	4	5
35	5x37	E3	adrenergic_off	14.0901	0	No	No	Yes	Yes	4	3
36	2x61	2x65	adrenergic_off	14.2546	0	No	No	Yes	Yes	6	5
37	3x54	5x61	adrenergic_off	13.8927	7.95724	No	No	No	No	8	9
38	3x54	5x64	adrenergic_off	12.334	6.59527	No	No	No	No	8	6
39	5x64	5x67	adrenergic_off	10.327	5.23331	No	No	No	No	6	5
40	4x59	4x60	adrenergic_off	10.4586	0	No	No	Yes	No	7	7
41	1x46	7x46	adrenergic_off	20.6169	0	No	No	No	No	8	9
42	1x46	7x47	adrenergic_off	17.1951	4.27993	No	No	No	No	8	6
43	1x45	7x47	adrenergic_off	15.4719	2.8564	No	No	No	No	5	6
44	1x41	1x45	adrenergic_off	11.9967	1.42913	No	No	No	No	5	5
45	5x58	I3	adrenergic_off	13.9914	0	Yes	Yes	Yes	No	9	3
46	3x32	Lig	Shared	21.0652	32.5827	No	No	Yes	Yes	7	0
47	2x56	3x28	Shared	27.9704	66.9994	No	No	Yes	Yes	8	5
48	2x56	3x32	Shared	26.1115	31.1013	No	No	No	No	8	7
49	3x36	Lig	Shared	28.5421	37.0846	No	No	Yes	Yes	6	0
50	6x51	Lig	Shared	28.9615	38.8552	Yes	Yes	Yes	Yes	7	0
51	7x42	Lig	Shared	21.7931	71.0573	Yes	Yes	Yes	Yes	7	0
52	1x39	2x61	Shared	16.06	28.3252	No	No	No	No	7	6
53	1x39	7x39	Shared	17.3802	30.1629	No	No	No	Yes	7	6
54	7x39	7x42	Shared	18.8937	40.9429	No	Yes	Yes	Yes	6	7
55	1x50	2x50	Shared	19.2844	21.0713	No	Yes	Yes	Yes	9	9
56	2x50	7x46	Shared	40.9747	12.7428	Yes	Yes	No	No	9	9
57	2x53	7x46	Shared	49.3358	11.3416	No	No	No	No	8	9
58	2x50	7x49	Shared	81.0487	24.8344	Yes	Yes	No	Yes	9	9
59	2x42	3x49	Shared	32.6753	100	Yes	Yes	Yes	Yes	8	9
60	2x42	4x46	Shared	39.8602	15.4611	Yes	Yes	No	No	8	8
61	2x45	4x46	Shared	40.8925	15.5544	No	No	No	No	9	8
62	2x45	4x50	Shared	42.9323	11.4293	No	No	Yes	Yes	9	9
63	6x44	6x48	Shared	100	68.8259	Yes	Yes	Yes	Yes	9	8
64	3x36	6x48	Shared	28.2953	37.3533	No	No	Yes	Yes	6	8
65	6x48	6x51	Shared	40.3743	61.5105	Yes	Yes	Yes	Yes	8	7
66	6x48	6x52	Shared	34.2505	37.6947	Yes	Yes	Yes	Yes	8	7
67	6x52	Lig	Shared	37.0471	57.3388	Yes	Yes	Yes	Yes	7	0
68	3x28	E1x50	Shared	18.2809	55.7249	Yes	Yes	Yes	Yes	5	8
69	5x43	Lig	Shared	25.1532	19.6813	No	No	Yes	Yes	7	0
70	5x39	5x43	Shared	23.1298	18.0656	Yes	Yes	No	No	8	7
71	E2x52	Lig	Shared	58.8114	17.894	Yes	No	Yes	Yes	6	0
72	5x461	Lig	Shared	14.4479	14.6533	No	No	Yes	Yes	6	0
73	3x37	5x461	Shared	12.6589	14.0264	Yes	No	No	No	7	6
74	3x38	4x53	Shared	20.0041	12.8137	No	No	No	No	8	8
75	3x49	I2x53	Shared	12.2723	19.0955	Yes	Yes	Yes	Yes	9	7
76	E2	E2x52	Shared	32.4902	14.9257	Yes	Yes	Yes	No	4	6
77	5x47	6x52	Shared	14.0613	20.8903	Yes	Yes	Yes	Yes	8	7
78	3x38	4x50	Shared	18.9924	12.9256	No	No	Yes	Yes	8	9
79	7x38	7x42	adrenergic_on	3.87415	18.4481	No	No	Yes	Yes	6	7
80	6x51	7x38	adrenergic_on	4.30598	18.8828	Yes	Yes	No	No	7	6
81	6x48	7x45	adrenergic_on	0	66.324	Yes	Yes	No	No	8	9
82	7x45	7x49	adrenergic_on	0	64.6728	No	No	No	Yes	9	9
83	5x54	6x44	adrenergic_on	0	91.4886	No	No	Yes	Yes	8	9
84	5x54	5x58	adrenergic_on	0	90.8412	No	No	Yes	Yes	8	9
85	3x50	5x58	adrenergic_on	0	57.8033	No	No	Yes	Yes	9	9
86	3x46	3x50	adrenergic_on	0	52.167	No	No	No	No	9	9
87	2x42	3x46	adrenergic_on	3.38063	95.2854	Yes	Yes	No	No	8	9
88	2x39	3x49	adrenergic_on	1.25026	70.2905	No	No	Yes	Yes	8	9
89	2x37	2x39	adrenergic_on	0	70.7495	No	No	No	No	7	8
90	2x37	2x40	adrenergic_on	1.96175	68.852	No	No	No	Yes	7	8
91	2x40	8x50	adrenergic_on	0	51.7845	No	Yes	Yes	Yes	8	8
92	7x54	8x50	adrenergic_on	0	20.9463	No	No	Yes	Yes	7	8
93	7x54	8x54	adrenergic_on	1.96175	16.9406	No	No	Yes	No	7	7
94	5x47	6x44	adrenergic_on	0	22.118	Yes	Yes	Yes	Yes	8	9
95	3x43	7x49	adrenergic_on	0	49.7528	No	No	No	Yes	8	9
96	3x43	7x53	adrenergic_on	0	57.9451	No	No	Yes	Yes	8	9
97	3x46	7x53	adrenergic_on	0	44.5848	No	No	Yes	Yes	9	9
98	3x37	4x53	adrenergic_on	7.32058	12.9237	Yes	No	No	No	7	8
99	2x56	7x42	adrenergic_on	0	39.4858	No	No	Yes	Yes	8	7
100	E1x50	E1x52	adrenergic_on	6.69134	40.3907	Yes	Yes	Yes	No	8	5
101	E1x51	E1x52	adrenergic_on	8.05264	20.241	No	No	Yes	No	3	5
102	3x24	E1x52	adrenergic_on	0	16.1999	No	Yes	Yes	No	5	5
103	3x47	5x58	adrenergic_on	0	26.4725	No	No	Yes	Yes	9	9
104	3x47	5x57	adrenergic_on	2.05634	25.4091	No	No	No	No	9	6
105	3x51	5x57	adrenergic_on	4.10857	24.4389	Yes	Yes	No	No	8	6
106	3x51	3x52	adrenergic_on	0	12.6458	Yes	Yes	No	No	8	5
107	3x52	I2x53	adrenergic_on	2.65268	11.6196	No	No	Yes	Yes	5	7
108	8x47	8x50	adrenergic_on	1.96175	28.1274	No	No	Yes	Yes	8	8
109	3x49	I2x57	adrenergic_on	8.77648	12.5711	Yes	Yes	Yes	Yes	9	6
110	2x38	I2x57	adrenergic_on	0	11.8435	No	No	Yes	Yes	7	6
111	3x56	I2x53	adrenergic_on	0	17.45	No	No	Yes	Yes	6	7
112	5x58	6x37	adrenergic_on	0	21.5396	Yes	Yes	No	No	9	0
113	5x62	6x37	adrenergic_on	0	18.95	No	No	No	No	5	0
114	5x62	5x66	adrenergic_on	3.61505	16.5731	No	No	No	No	5	5
115	5x66	6x30	adrenergic_on	0	15.2689	No	No	No	Yes	5	0
116	5x69	6x30	adrenergic_on	0	10.4424	No	Yes	No	Yes	5	0
117	4x59	5x39	adrenergic_on	0	14.5544	No	No	Yes	Yes	7	8
118	E1x49	E1x51	adrenergic_on	4.58976	12.1551	No	No	No	No	4	3
119	8x47	8x48	adrenergic_on	0	22.1665	No	No	No	No	8	5
120	8x48	8x51	adrenergic_on	5.3794	18.1738	No	No	No	No	5	8
121	7x55	8x51	adrenergic_on	0	14.1663	No	No	No	No	5	8
122	1x52	8x54	adrenergic_on	9.2371	12.9219	No	No	Yes	No	7	7
123	1x36	2x61	adrenergic_on	0	26.0732	No	No	No	No	6	6
124	1x36	2x65	adrenergic_on	1.86716	23.8139	No	No	Yes	Yes	6	5
125	1x31	1x35	adrenergic_on	7.40284	12.4909	No	Yes	No	No	3	5
126	1x35	2x65	adrenergic_on	9.23298	17.0264	No	No	Yes	Yes	5	5
127	7x55	7x56	adrenergic_on	1.46823	10.1364	No	No	No	No	5	7
128	2x46	2x50	adrenergic_on	0	11.1551	No	Yes	Yes	Yes	9	9

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
3x28	Lig	adrenergic_off	4.04399	0	0	0	1	0
3x32	Lig	Shared	18.8593	14.4464	1	1	1	0
3x33	Lig	Shared	9.60899	9.27028	0	0	1	0
3x36	Lig	Shared	5.77113	8.02806	0	0	1	0
5x43	Lig	Shared	5.56619	4.45819	0	0	1	0
5x461	Lig	Shared	3.56595	4.17972	0	0	1	0
6x51	Lig	Shared	9.99065	9.45208	1	1	1	0
6x52	Lig	Shared	8.92726	4.65764	1	1	1	0
6x55	Lig	Shared	7.47309	5.85389	1	1	1	0
7x38	Lig	Shared	14.9072	15.1394	1	1	1	0
7x42	Lig	Shared	5.01458	6.24708	1	1	1	0
2x56	3x28	Shared	3.69286	4.26667	0	1	2	1
2x56	3x32	Shared	5.5619	7.30708	0	1	2	1
2x57	7x39	adrenergic_off	3.79095	0	1	1	2	2
2x57	7x42	Shared	6.86673	2.49917	1	1	2	1
2x59	3x28	Shared	5.23345	7.33875	0	0	2	1
3x28	E1x50	Shared	10.047	6.78611	0	0	1	2
3x32	7x42	Shared	7.89583	8.23861	1	1	1	1
3x33	4x57	Shared	5.15554	3.49958	0	0	1	2
3x36	6x48	Shared	6.85226	6.37292	0	0	1	2
3x37	4x57	adrenergic_off	3.61863	0	0	0	2	2
3x37	5x461	Shared	8.13649	7.76944	0	0	2	1
E2	E2	Shared	63.2564	35.7608	1	1	2	2
E2	E2x52	Shared	7.73298	3.20111	1	1	2	1
5x39	E2	Shared	9.51482	6.37389	1	1	2	2
5x39	5x43	Shared	10.5224	9.46778	1	1	2	1
5x40	6x55	Shared	4.57321	4.41042	0	0	2	1
5x44	6x52	Shared	3.555	3.83708	0	0	2	1
5x47	6x52	Shared	25.1086	20.1503	0	1	2	1
6x48	6x51	Shared	4.86762	3.27111	1	1	2	1
6x48	6x52	Shared	4.79643	6.59972	1	1	2	1
6x51	6x52	Shared	7.87357	5.40375	1	1	1	1
6x51	6x55	Shared	4.71815	5.79792	1	1	1	1
6x51	7x34	Shared	6.6544	5.51486	1	1	1	2
6x51	7x38	Shared	8.13435	11.2686	1	1	1	1
7x38	7x42	Shared	6.96065	11.6161	1	1	1	1
7x39	7x42	Shared	12.2168	5.25264	1	0	2	1
E2x52	Lig	Shared	6.19202	9.39278	1	1	1	0
3x29	E2x52	Shared	4.535	2.46319	0	0	2	1
5x39	E2x52	adrenergic_off	3.7006	0	1	1	2	1
2x60	3x28	Shared	3.52536	3.68042	0	0	2	1
2x56	7x42	adrenergic_on	0	4.20417	0	1	2	1
5x47	6x48	adrenergic_on	0	3.2575	0	1	2	2
5x44	6x55	adrenergic_on	0	3.56569	0	0	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	adrenergic_off	alpha_off beta_off
	adrenergic_on	alpha_on beta_on

Network Difference
Value	adrenergic_off	adrenergic_on
I_min	3.55321	3.08653
Number of Linked Nodes	280	271
Number of Specific Nodes	11 (3.93%)	2 (0.74%)
Number of Shared Nodes	269 (96.07%)	269 (99.26%)
Number of Links	305	302
Number of Specific Links	117 (38.36%)	114 (37.75%)
Number of Shared Links	188 (61.64%)	188 (62.25%)
Number of Hubs	35	36
Number of Specific Hubs	12 (34.29%)	13 (36.11%)
Number of Shared Hubs	23 (65.71%)	23 (63.89%)
Average % Shared Neighbours (Jaccard)	49.19
Average % Shared Neighbours (Otsuka)	57.48
Average % Shared Neighbours (Overlap Coefficient)	65.66
Average % Shared Cliques (k3-6)	84.38
Graphlets Similarity	0.629408

Paths Difference
Value	adrenergic_off	adrenergic_on
Number Of Nodes in MetaPath	73	76
Specific Nodes in MetaPath	31 (42.47%)	34 (44.74%)
Shared Nodes in MetaPath	269 (96.07%)	269 (96.07%)
Number Of Links MetaPath	78	83
Specific Links in MetaPath	45 (57.69%)	50 (60.24%)
Shared Links in MetaPath	188 (61.64%)	188 (61.64%)
Number of Shortest Paths	64370	121654
Length Of Smallest Path	3	3
Average Path Length	12.5901	15.7339
Length of Longest Path	29	34
Minimum Path Strength	0.53125	0.372917
Average Path Strength	5.4931	5.1304
Maximum Path Strength	17.6317	13.8231
Minimum Path Correlation	0.70131	0.7025
Average Path Correlation	0.909938	0.913308
Maximum Path Correlation	0.988452	0.989167
Minimum % Of Corr. Nodes	4.34783	3.33333
Average % Of Corr. Nodes	43.1109	35.5036
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	43.6071	46.7701
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

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