Orange: nodes, hubs and links specific of adrenergic_on_gp network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of adrenergic_off network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.


Index Hub Owner adrenergic_on_gp Avg Int. Strength adrenergic_off Avg Int. Strength adrenergic_on_gp Num Of Links adrenergic_off Num Of Links ConSurf
1G.HN.30 adrenergic_on_gp00408
2G.HN.34 adrenergic_on_gp00403
3G.S1.06 adrenergic_on_gp00408
4G.S2.06 adrenergic_on_gp00408
5G.S2.08 adrenergic_on_gp20.83330405
6G.S3.02 adrenergic_on_gp00403
7G.S3.03 adrenergic_on_gp62.50407
8G.S3.04 adrenergic_on_gp70.83330506
9G.S3.05 adrenergic_on_gp250406
10G.S3.06 adrenergic_on_gp91.66670506
11G.H2.01 adrenergic_on_gp00409
12G.H2.06 adrenergic_on_gp91.66670609
13G.H2.07 adrenergic_on_gp83.33330509
14G.h2s4.01 adrenergic_on_gp45.83330509
15G.h2s4.02 adrenergic_on_gp00407
16G.S4.02 adrenergic_on_gp250407
17G.s4h3.04 adrenergic_on_gp37.50408
18G.H3.01 adrenergic_on_gp00409
19G.H3.09 adrenergic_on_gp87.50709
20G.H3.13 adrenergic_on_gp41.66670405
21G.H3.17 adrenergic_on_gp66.66670604
22G.H3.18 adrenergic_on_gp250409
23G.S5.04 adrenergic_on_gp63.88890409
24G.S5.05 adrenergic_on_gp77.77780609
25G.HG.03 adrenergic_on_gp00406
26G.HG.04 adrenergic_on_gp29.16670408
27G.hgh4.02 adrenergic_on_gp41.66670408
28G.hgh4.05 adrenergic_on_gp00406
29G.hgh4.08 adrenergic_on_gp00501
30G.H4.08 adrenergic_on_gp00403
31G.H4.10 adrenergic_on_gp41.66670406
32G.H4.12 adrenergic_on_gp41.66670405
33G.H4.14 adrenergic_on_gp00406
34G.H4.15 adrenergic_on_gp56.94440508
35G.h4s6.02 adrenergic_on_gp00407
36G.S6.02 adrenergic_on_gp87.50508
37G.S6.05 adrenergic_on_gp33.33330405
38G.s6h5.01 adrenergic_on_gp27.77780409
39G.H5.03 adrenergic_on_gp00508
40G.H5.05 adrenergic_on_gp00405
41G.H5.08 adrenergic_on_gp83.33330408
42G.H5.17 adrenergic_on_gp36.11110505
43G.H5.25 adrenergic_on_gp250506
44b.lhb1x3 adrenergic_on_gp00402
45b.lhb1x6 adrenergic_on_gp00603
46b.l1x3 adrenergic_on_gp1000509
47b.l1x6 adrenergic_on_gp41.66670509
48b.b2x1 adrenergic_on_gp72.22220508
49b.b2x5 adrenergic_on_gp91.66670607
50b.b3x3 adrenergic_on_gp41.66670508
51b.l3x1 adrenergic_on_gp27.77780409
52b.l3x2 adrenergic_on_gp500409
53b.b4x3 adrenergic_on_gp27.77780407
54b.b4x6 adrenergic_on_gp1000609
55b.l4x2 adrenergic_on_gp62.50504
56b.b5x2 adrenergic_on_gp00407
57b.b5x3 adrenergic_on_gp1000609
58b.b5x5 adrenergic_on_gp00405
59b.b5x7 adrenergic_on_gp66.66670407
60b.l5x1 adrenergic_on_gp87.50508
61b.l5x5 adrenergic_on_gp1000609
62b.b6x5 adrenergic_on_gp1000506
63b.l6x5 adrenergic_on_gp58.33330404
64b.b7x1 adrenergic_on_gp16.66670404
65b.b7x4 adrenergic_on_gp00408
66b.b8x4 adrenergic_on_gp94.44440506
67b.l9x3 adrenergic_on_gp88.88890609
68b.l9x6 adrenergic_on_gp10001008
69b.b10x5 adrenergic_on_gp45.83330509
70b.b11x4 adrenergic_on_gp91.66670409
71b.l11x2 adrenergic_on_gp1000509
72b.b12x5 adrenergic_on_gp00406
73b.b12x6 adrenergic_on_gp1000708
74b.b13x7 adrenergic_on_gp94.44440507
75b.l13x3 adrenergic_on_gp95.83330509
76b.l13x6 adrenergic_on_gp41.66670509
77b.b15x1 adrenergic_on_gp66.66670509
78b.b15x2 adrenergic_on_gp29.16670406
79b.b16x4 adrenergic_on_gp87.50406
80b.b16x5 adrenergic_on_gp18.05560405
81b.b16x6 adrenergic_on_gp1000608
82b.b17x5 adrenergic_on_gp31.94440407
83b.b17x7 adrenergic_on_gp73.61110408
84b.l17x3 adrenergic_on_gp87.50709
85b.l17x6 adrenergic_on_gp27.77780409
86b.b18x3 adrenergic_on_gp79.16670408
87b.b18x5 adrenergic_on_gp41.66670405
88b.l18x1 adrenergic_on_gp1000706
89b.l18x2 adrenergic_on_gp33.33330407
90b.b19x2 adrenergic_on_gp95.83330606
91b.b19x4 adrenergic_on_gp55.55560408
92b.l19x1 adrenergic_on_gp00409
93b.l19x2 adrenergic_on_gp41.66670509
94b.b20x4 adrenergic_on_gp1000508
95b.b20x6 adrenergic_on_gp1000606
96b.b20x7 adrenergic_on_gp00409
97b.l20x2 adrenergic_on_gp11.11110409
98b.b21x1 adrenergic_on_gp48.61110407
99b.b21x3 adrenergic_on_gp00406
100b.b21x5 adrenergic_on_gp00404
101b.b21x7 adrenergic_on_gp91.66670605
102b.l21x2 adrenergic_on_gp00404
103b.l21x5 adrenergic_on_gp00404
104b.b22x5 adrenergic_on_gp45.83330507
105b.l22x5 adrenergic_on_gp37.50509
106b.b23x6 adrenergic_on_gp1000607
107b.l23x1 adrenergic_on_gp19.44440506
108b.l23x2 adrenergic_on_gp250408
109b.b24x4 adrenergic_on_gp58.33330406
110b.b24x6 adrenergic_on_gp41.66670408
111b.l24x3 adrenergic_on_gp00405
112b.l25x3 adrenergic_on_gp1000609
113b.b26x3 adrenergic_on_gp48.61110406
114b.l27x1 adrenergic_on_gp1000809
115b.l27x2 adrenergic_on_gp750409
116b.b28x3 adrenergic_on_gp00407
117b.b28x4 adrenergic_on_gp750406
118b.b28x6 adrenergic_on_gp1000409
119g.h1x11 adrenergic_on_gp00409
120g.l1x4 adrenergic_on_gp00408
121g.h2x9 adrenergic_on_gp00404
122g.h2x11 adrenergic_on_gp58.33330406
123g.ctx3 adrenergic_on_gp87.50509
124g.ctx6 adrenergic_on_gp00506
125g.ctx14 adrenergic_on_gp4.166670509
126g.ctx16 adrenergic_on_gp1000708
127g.ctx17 adrenergic_on_gp00407
1281x31 adrenergic_on_gp00525
1291x50 adrenergic_on_gp45.83330539
1302x40 adrenergic_on_gp19.44440429
1312x46 adrenergic_on_gp65.27780419
1323x24 adrenergic_on_gp025436
1333x34 adrenergic_on_gp00437
1343x35 adrenergic_on_gp41.66670437
1353x42 adrenergic_on_gp500418
1363x50 adrenergic_on_gp37.50439
137I2x51 adrenergic_on_gp30.55560417
1384x59 adrenergic_on_gp00428
1395x44 adrenergic_on_gp00419
1405x48 adrenergic_on_gp250429
1416x37 adrenergic_on_gp00428
1426x49 adrenergic_on_gp250427
1436x55 adrenergic_on_gp29.16670538
1447x34 adrenergic_on_gp00416
1457x37 adrenergic_on_gp250437
1467x39 adrenergic_on_gp00437
1477x49 adrenergic_on_gp83.33330439
1487x55 adrenergic_on_gp00437
1492x42 Shared73.611164.2857668
1502x50 Shared69.44440559
1512x65 Shared00447
152E1x50 Shared91.6667100578
1533x28 Shared66.666725557
1543x49 Shared33.333355.9524469
1553x51 Shared45.83330448
156I2x53 Shared45.833325579
157I2x57 Shared45.833325457
1584x50 Shared41.66670449
159E2 Shared66.66671009117
1605x39 Shared250445
1615x47 Shared95.833325648
1625x50 Shared00446
1635x58 Shared95.83330658
1646x44 Shared69.4444100559
1656x48 Shared10096.4286859
1666x51 Shared95.833396.4286668
1676x52 Shared70.833396.4286558
168E3 Shared5067.2619575
1697x42 Shared95.8333100758
1707x53 Shared81.944445.8333559
1718x50 Shared95.8333100558
172Lig Shared10010012120
1731x60 adrenergic_off00348
1742x57 adrenergic_off00348
175E1x52 adrenergic_off042.8571347
1763x37 adrenergic_off00348
1773x41 adrenergic_off00347
1784x60 adrenergic_off00248
179E2x52 adrenergic_off025347
180I3 adrenergic_off2525380
1818x49 adrenergic_off025248
1828x54 adrenergic_off00348
1836x31 adrenergic_off00147
   
Orange: nodes, hubs and links specific of adrenergic_on_gp network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of adrenergic_off network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Owner adrenergic_on_gp Recurrence adrenergic_off Recurrence adrenergic_on_gp Hub1? adrenergic_off Hub1? adrenergic_on_gp Hub2? adrenergic_off Hub2? ConSurf1 ConSurf2
1b.b3x6 b.l1x3 adrenergic_on_gp53.45870NoNoYesNo99
2b.b3x6 b.l3x2 adrenergic_on_gp53.43010NoNoYesNo99
3b.b4x6 b.l1x3 adrenergic_on_gp52.09690YesNoYesNo99
4b.l1x4 b.l3x2 adrenergic_on_gp53.20520NoNoYesNo69
5G.hns1.01 b.l1x4 adrenergic_on_gp53.06320NoNoNoNo36
6G.S1.03 G.hns1.01 adrenergic_on_gp53.04130NoNoNoNo93
7b.l2x5 b.l4x2 adrenergic_on_gp45.97220NoNoYesNo54
8b.l4x2 g.ctx15 adrenergic_on_gp46.29840YesNoNoNo49
9b.l26x5 g.ctx15 adrenergic_on_gp48.30370NoNoNoNo59
10b.l26x5 g.ctx4 adrenergic_on_gp99.71280NoNoNoNo57
11g.ctx3 g.ctx4 adrenergic_on_gp99.74670YesNoNoNo97
12g.ctx3 g.ctx6 adrenergic_on_gp99.91540YesNoYesNo96
13b.lhb1x6 g.ctx6 adrenergic_on_gp99.06260YesNoYesNo36
14b.lhb1x6 b.lhb1x9 adrenergic_on_gp99.84350YesNoNoNo33
15b.lhb1x11 b.lhb1x9 adrenergic_on_gp99.8750NoNoNoNo43
16b.b25x7 b.lhb1x11 adrenergic_on_gp99.93760NoNoNoNo74
17b.b25x7 b.b28x6 adrenergic_on_gp1000NoNoYesNo79
18b.b27x3 b.b28x6 adrenergic_on_gp50.03970NoNoYesNo89
19b.b27x3 b.l25x3 adrenergic_on_gp49.98090NoNoYesNo89
20b.l25x3 b.l27x2 adrenergic_on_gp99.44450YesNoYesNo99
21b.l25x4 b.l27x2 adrenergic_on_gp99.47420NoNoYesNo59
228x56 b.l25x4 adrenergic_on_gp97.8490NoNoNoNo75
231x60 8x56 adrenergic_on_gp97.80343.43409NoYesNoNo87
241x60 I1x50 adrenergic_on_gp97.69939.25766NoYesNoNo89
252x40 I1x50 adrenergic_on_gp96.5110YesNoNoNo99
262x37 2x40 adrenergic_on_gp96.98771.96175NoNoYesNo89
272x37 2x39 adrenergic_on_gp96.93420NoNoNoNo89
282x39 3x49 adrenergic_on_gp83.87691.25026NoNoYesYes99
293x53 I2x53 adrenergic_on_gp23.82971.3284NoNoYesYes99
303x53 G.H5.19 adrenergic_on_gp23.63830NoNoNoNo98
31G.H5.15 G.H5.19 adrenergic_on_gp23.44680NoNoNoNo88
32G.H5.15 I2x50 adrenergic_on_gp23.25520NoNoNoNo89
33b.b28x4 b.b28x6 adrenergic_on_gp49.95090YesNoYesNo69
34b.b28x4 b.l25x3 adrenergic_on_gp49.75770YesNoYesNo69
352x39 I2x57 adrenergic_on_gp13.00370.0945918NoNoYesYes97
36I2x53 I2x57 adrenergic_on_gp12.2680.312564YesYesYesYes97
37G.S1.03 G.S3.06 adrenergic_on_gp52.05520NoNoYesNo96
38G.H5.16 I2x50 adrenergic_on_gp14.39760NoNoNoNo79
395x68 G.H5.16 adrenergic_on_gp14.20350NoNoNoNo77
40G.S3.06 G.h2s4.01 adrenergic_on_gp17.21220YesNoYesNo69
41G.S1.05 G.h2s4.01 adrenergic_on_gp17.26450NoNoYesNo99
42G.S1.05 G.S4.02 adrenergic_on_gp17.03410NoNoYesNo97
43G.H4.10 G.H4.14 adrenergic_on_gp11.72090YesNoYesNo66
44G.H3.06 G.H4.14 adrenergic_on_gp15.63350NoNoYesNo76
45G.H3.09 G.S5.02 adrenergic_on_gp15.39390YesNoNoNo96
46G.S4.02 G.S5.02 adrenergic_on_gp16.45750YesNoNoNo76
47G.S3.06 b.l5x5 adrenergic_on_gp35.43850YesNoYesNo69
48b.l2x3 b.l2x5 adrenergic_on_gp44.6220NoNoNoNo85
49b.b3x1 b.l2x3 adrenergic_on_gp44.57110NoNoNoNo58
50b.b3x1 b.b6x5 adrenergic_on_gp44.52060NoNoYesNo56
51b.b2x4 b.b6x5 adrenergic_on_gp41.86570NoNoYesNo66
52b.b10x4 b.b2x4 adrenergic_on_gp41.8090NoNoNoNo66
53b.b10x2 b.b10x4 adrenergic_on_gp40.79670NoNoNoNo66
54b.b10x2 b.b14x3 adrenergic_on_gp37.24010NoNoNoNo65
55b.b11x5 b.b14x3 adrenergic_on_gp36.04270NoNoNoNo65
56b.b10x1 b.b11x5 adrenergic_on_gp35.9190NoNoNoNo96
57b.b10x1 b.l9x6 adrenergic_on_gp35.8670NoNoYesNo98
58G.H2.06 b.l9x6 adrenergic_on_gp24.67980YesNoYesNo98
59b.l1x6 b.l27x1 adrenergic_on_gp14.53880YesNoYesNo99
60b.l1x6 b.l3x1 adrenergic_on_gp21.93190YesNoYesNo99
61b.l3x1 b.l5x5 adrenergic_on_gp36.73330YesNoYesNo99
62b.b2x1 b.l27x1 adrenergic_on_gp30.96620YesNoYesNo89
63b.b2x1 b.l3x1 adrenergic_on_gp14.63990YesNoYesNo89
64G.H3.17 b.l27x1 adrenergic_on_gp22.34440YesNoYesNo49
653x46 3x50 adrenergic_on_gp33.69220NoNoYesNo99
662x42 3x46 adrenergic_on_gp61.30893.38063YesYesNoNo89
67G.H2.06 b.l19x1 adrenergic_on_gp24.22550YesNoYesNo99
68b.l17x5 b.l19x1 adrenergic_on_gp24.24940NoNoYesNo69
69b.l17x5 b.l19x2 adrenergic_on_gp24.14710NoNoYesNo69
70b.l17x3 b.l19x2 adrenergic_on_gp23.06630YesNoYesNo99
71b.b16x5 b.l14x6 adrenergic_on_gp17.90220YesNoNoNo53
72b.b16x7 b.l14x6 adrenergic_on_gp17.46290NoNoNoNo93
73b.b16x7 b.l16x3 adrenergic_on_gp16.5840NoNoNoNo93
74b.b17x2 b.l16x3 adrenergic_on_gp14.82550NoNoNoNo33
75b.b17x2 g.h1x13 adrenergic_on_gp14.38570NoNoNoNo31
76g.h1x13 g.h1x9 adrenergic_on_gp13.94590NoNoNoNo16
77g.h1x12 g.h1x9 adrenergic_on_gp12.22660NoNoNoNo66
78b.b20x6 b.l17x3 adrenergic_on_gp16.54850YesNoYesNo69
79b.b19x2 b.b20x6 adrenergic_on_gp10.14580YesNoYesNo66
80G.H3.17 b.l23x1 adrenergic_on_gp28.4240YesNoYesNo46
81b.l21x7 b.l23x1 adrenergic_on_gp48.06630NoNoYesNo56
82b.l21x7 b.l23x2 adrenergic_on_gp46.80470NoNoYesNo58
83b.b23x6 b.l23x2 adrenergic_on_gp41.11160YesNoYesNo78
84b.b23x6 b.b24x6 adrenergic_on_gp36.05220YesNoYesNo78
85b.b21x7 b.b24x6 adrenergic_on_gp34.79790YesNoYesNo58
86b.l25x6 b.l27x1 adrenergic_on_gp21.80450NoNoYesNo89
87b.l23x1 b.l25x6 adrenergic_on_gp21.53410YesNoNoNo68
88b.b3x2 b.b4x6 adrenergic_on_gp51.51650NoNoYesNo59
89b.b2x5 b.b3x2 adrenergic_on_gp51.5510YesNoNoNo75
90b.b2x5 b.l26x1 adrenergic_on_gp51.27720YesNoNoNo77
91b.l26x1 b.l26x3 adrenergic_on_gp51.14690NoNoNoNo77
92b.l26x3 b.l26x5 adrenergic_on_gp51.43720NoNoNoNo75
93b.b6x1 b.l9x6 adrenergic_on_gp16.79640NoNoYesNo98
94b.b2x1 b.b6x1 adrenergic_on_gp16.59350YesNoNoNo89
95b.b21x7 b.b23x2 adrenergic_on_gp15.22190YesNoNoNo56
96b.b22x5 b.b23x2 adrenergic_on_gp14.58830YesNoNoNo76
97b.b20x5 b.b21x7 adrenergic_on_gp13.31950NoNoYesNo75
98b.b20x5 b.b21x4 adrenergic_on_gp12.68530NoNoNoNo75
99b.b20x7 b.b21x4 adrenergic_on_gp12.05170YesNoNoNo95
1005x54 6x44 adrenergic_on_gp32.6370NoNoYesYes89
1015x54 5x58 adrenergic_on_gp31.03380NoNoYesYes88
1023x50 5x58 adrenergic_on_gp31.91040YesNoYesYes98
1036x48 7x45 adrenergic_on_gp22.9820YesYesNoNo99
1047x45 7x49 adrenergic_on_gp23.23590NoNoYesNo99
1053x43 7x49 adrenergic_on_gp24.96160NoNoYesNo89
1063x43 7x53 adrenergic_on_gp27.00390NoNoYesYes89
1073x46 7x53 adrenergic_on_gp27.54570NoNoYesYes99
1081x36 2x61 adrenergic_on_gp11.04550NoNoNoNo68
1091x36 2x65 adrenergic_on_gp10.10821.86716NoNoYesYes67
1103x49 I2x53 Shared12.709212.2723YesYesYesYes99
1112x42 3x49 Shared72.554532.6753YesYesYesYes89
1121x39 7x39 Shared12.919817.3802NoNoYesNo57
1137x39 7x42 Shared17.604718.8937YesNoYesYes78
1146x48 6x51 Shared20.648940.3743YesYesYesYes98
1156x44 6x48 Shared24.2213100YesYesYesYes99
1167x42 Lig Shared19.30521.7931YesYesYesYes80
1176x51 Lig Shared12.875128.9615YesYesYesYes80
1183x36 Lig Shared12.84228.5421NoNoYesYes70
1193x36 6x48 Shared13.024828.2953NoNoYesYes79
1206x52 Lig Shared19.456537.0471YesYesYesYes80
1216x48 6x52 Shared13.212434.2505YesYesYesYes98
1222x45 4x46 Shared10.768240.8925NoNoNoNo98
1232x42 4x46 Shared10.858739.8602YesYesNoNo88
1241x39 2x61 Shared11.982716.06NoNoNoNo58
1253x28 Lig Shared13.485844.3307YesYesYesYes70
1263x28 E1x50 Shared10.514418.2809YesYesYesYes78
1273x32 Lig adrenergic_off1.4974421.0652NoNoYesYes80
1282x56 3x28 adrenergic_off0.76197927.9704NoNoYesYes87
1292x56 3x32 adrenergic_off0.74898126.1115NoNoNoNo88
1303x33 Lig adrenergic_off0.10928134.4067NoNoYesYes80
1312x57 7x42 adrenergic_off3.751610.8534NoYesYesYes88
1321x50 2x50 adrenergic_off4.4555419.2844YesNoYesYes99
1332x50 7x46 adrenergic_off0.63729540.9747YesYesNoNo99
1342x53 7x46 adrenergic_off0.34347449.3358NoNoNoNo89
1352x53 2x56 adrenergic_off052.2805NoNoNoNo88
1362x50 7x49 adrenergic_off2.0258181.0487YesYesYesNo99
1377x49 7x53 adrenergic_off063.4547YesNoYesYes99
1387x53 8x50 adrenergic_off053.831YesYesYesYes98
1398x50 8x54 adrenergic_off014.9949YesYesNoYes88
1408x50 I1x50 adrenergic_off1.1361630.3804YesYesNoNo89
1418x49 I1x50 adrenergic_off019.7203NoYesNoNo89
1422x45 4x50 adrenergic_off7.9515742.9323NoNoYesYes99
1433x34 4x50 adrenergic_off026.1567YesNoYesYes79
1443x34 4x57 adrenergic_off0.25781730.7053YesNoNoNo78
1453x33 4x57 adrenergic_off0.17365432.2106NoNoNoNo88
1463x43 6x44 adrenergic_off063.4423NoNoYesYes89
1473x39 6x44 adrenergic_off069.1425NoNoYesYes99
1482x50 3x39 adrenergic_off0.29746167.8511YesYesNoNo99
1492x59 3x28 adrenergic_off0.75141812.7658NoNoYesYes77
1505x43 Lig adrenergic_off8.2420425.1532NoNoYesYes70
1515x39 5x43 adrenergic_off7.4933223.1298YesYesNoNo57
1524x60 5x39 adrenergic_off0.74966341.6492NoYesYesYes85
1534x58 4x60 adrenergic_off020.8883NoNoNoYes68
1543x30 4x58 adrenergic_off1.4998115.6776NoNoNoNo86
155E2x52 Lig adrenergic_off8.1326658.8114NoYesYesYes70
1565x39 E2x52 adrenergic_off022.48YesYesNoYes57
1575x461 Lig adrenergic_off6.2241914.4479NoNoYesYes00
1583x37 5x461 adrenergic_off6.3048112.6589NoYesNoNo80
1593x38 4x53 adrenergic_off7.6923220.0041NoNoNoNo88
1603x40 6x44 adrenergic_off0.12991631.1577NoNoYesYes99
1613x40 5x50 adrenergic_off0.11665829.6484NoNoYesYes96
1623x41 4x53 adrenergic_off024.3348NoYesNoNo78
1633x41 5x50 adrenergic_off0.42653223.8083NoYesYesYes76
1643x43 6x41 adrenergic_off059.9054NoNoNoNo87
1655x58 6x41 adrenergic_off0.46594856.2698YesYesNoNo87
1665x58 5x61 adrenergic_off035.3856YesYesNoNo87
1673x51 5x61 adrenergic_off020.2303YesYesNoNo87
168E2 E2x52 adrenergic_off6.6352932.4902YesYesNoYes77
1696x55 Lig adrenergic_off0.066127712.6095YesNoYesYes80
1705x40 6x55 adrenergic_off0.957620.3085NoNoYesNo88
1715x40 6x59 adrenergic_off0.76620319.0829NoNoNoNo87
1725x47 6x52 adrenergic_off6.8008814.0613YesYesYesYes88
1736x40 7x49 adrenergic_off015.9778NoNoYesNo89
1746x40 7x52 adrenergic_off015.476NoNoNoNo88
1755x37 6x59 adrenergic_off0.38321515.3568NoNoNoNo67
1765x37 E3 adrenergic_off014.0901NoNoYesYes65
1772x61 2x65 adrenergic_off014.2546NoNoYesYes87
1783x54 5x61 adrenergic_off0.11041913.8927NoNoNoNo87
1793x54 5x64 adrenergic_off0.22080512.334NoNoNoNo86
1805x64 5x67 adrenergic_off0.11041910.327NoNoNoNo68
1814x59 4x60 adrenergic_off0.00022746610.4586YesNoNoYes88
1821x46 7x46 adrenergic_off020.6169NoNoNoNo89
1831x46 7x47 adrenergic_off0.89225217.1951NoNoNoNo88
1841x45 7x47 adrenergic_off0.59488915.4719NoNoNoNo58
1851x41 1x45 adrenergic_off0.29746111.9967NoNoNoNo55
1865x58 I3 adrenergic_off013.9914YesYesNoYes80
1873x38 4x50 adrenergic_off7.7859418.9924NoNoYesYes89

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Midway



Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Node1Node2OwnerNet1LinkStrengthNet2LinkStrengthComm1Comm2Node1ShellNode2Shell
3x28LigShared4.043993.026390010
3x32LigShared18.859314.44641110
3x33LigShared9.608999.270280010
3x36LigShared5.771138.028060010
5x43LigShared5.566194.458190010
5x461LigShared3.565954.179720010
6x51LigShared9.990659.452081110
6x52LigShared8.927264.657641110
6x55LigShared7.473095.853891110
7x38LigShared14.907215.13941110
7x42LigShared5.014586.247081110
2x563x28Shared3.692864.266670121
2x563x32Shared5.56197.307080121
2x577x39adrenergic_off3.7909501122
2x577x42Shared6.866732.499171121
2x593x28Shared5.233457.338750021
3x28E1x50Shared10.0476.786110012
3x327x42Shared7.895838.238611111
3x334x57Shared5.155543.499580012
3x366x48Shared6.852266.372920012
3x374x57adrenergic_off3.6186300022
3x375x461Shared8.136497.769440021
E2E2Shared63.256435.76081122
E2E2x52Shared7.732983.201111121
5x39E2Shared9.514826.373891122
5x395x43Shared10.52249.467781121
5x406x55Shared4.573214.410420021
5x446x52Shared3.5553.837080121
5x476x52Shared25.108620.15030121
6x486x51Shared4.867623.271111121
6x486x52Shared4.796436.599721121
6x516x52Shared7.873575.403751111
6x516x55Shared4.718155.797921111
6x517x34Shared6.65445.514861112
6x517x38Shared8.1343511.26861111
7x387x42Shared6.9606511.61611111
7x397x42Shared12.21685.252641021
E2x52LigShared6.192029.392781110
3x29E2x52Shared4.5352.463190021
5x39E2x52adrenergic_off3.700601121
2x603x28Shared3.525363.680420021
2x567x42adrenergic_on_gp04.204170121
2x607x42adrenergic_on_gp02.808330021
5x476x48adrenergic_on_gp03.25750122
6x557x34adrenergic_on_gp02.991112
5x446x55adrenergic_on_gp03.565690121

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
Id Description
adrenergic_on_gp alpha_on_gp
beta_on_gp
adrenergic_off alpha_off
beta_off
Network Difference
Value adrenergic_on_gp adrenergic_off
Imin 2.70222 3.55321
Number of Linked Nodes 917 280
Number of Specific Nodes 648 (70.67%) 11  (3.93%)
Number of Shared Nodes 269 (29.33%) 269  (96.07%)
Number of Links 1083 305
Number of Specific Links 895 (82.64%) 117  (38.36%)
Number of Shared Links 188 (17.36%) 188  (61.64%)
Number of Hubs 172 35
Number of Specific Hubs 148 (86.05%) 11  (31.43%)
Number of Shared Hubs 24 (13.95%) 24  (68.57%)
Average % Shared Neighbours (Jaccard) 14.61
Average % Shared Neighbours (Otsuka) 17.13
Average % Shared Neighbours (Overlap Coefficient) 19.62
Average % Shared Cliques (k3-6) 52.10
Graphlets Similarity 0.678044
Paths Difference
Value adrenergic_on_gp adrenergic_off
Number Of Nodes in MetaPath 121 73
Specific Nodes in MetaPath 98 (80.99%) 50  (68.49%)
Shared Nodes in MetaPath 269 (29.33%) 269  (29.33%)
Number Of Links MetaPath 126 78
Specific Links in MetaPath 109 (86.51%) 61  (78.21%)
Shared Links in MetaPath 188 (17.36%) 188  (17.36%)
Number of Shortest Paths 3941051 64370
Length Of Smallest Path 3 3
Average Path Length 45.9059 12.5901
Length of Longest Path 78 29
Minimum Path Strength 0.372917 0.53125
Average Path Strength 5.69032 5.4931
Maximum Path Strength 20.9476 17.6317
Minimum Path Correlation 0.700694 0.70131
Average Path Correlation 0.97916 0.909938
Maximum Path Correlation 1 0.988452
Minimum % Of Corr. Nodes 1.42857 4.34783
Average % Of Corr. Nodes 28.4891 43.1109
Maximum % Of Corr. Nodes 100 100
Minimum Path Hubs % 0 0
Average Path Hubs % 46.7322 43.6071
Maximum Path Hubs % 100 100

Details about the values in these tables can be found in the corresponding documentation page .

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download adrenergic_off_on_gp.zip<



You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.



You can also  read or  download a guide explaining the meaning of all files and numerical data.