psnGPCR

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Orange: nodes, hubs and links specific of alicarboxylic_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of alicarboxylic_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	alicarboxylic_off Int. Strength	alicarboxylic_on Int. Strength	alicarboxylic_off Hub1?	alicarboxylic_on Hub1?	alicarboxylic_off Hub2?	alicarboxylic_on Hub2?	ConSurf1	ConSurf2
1	1x31	Lig	alicarboxylic_off	100	0	No	No	Yes	Yes	2	0
2	E1x50	Lig	alicarboxylic_off	100	0	Yes	Yes	Yes	Yes	8	0
3	E2x50	Lig	alicarboxylic_off	100	0	Yes	No	Yes	Yes	9	0
4	1x23	7x25	alicarboxylic_off	100	0	Yes	No	No	No	3	4
5	1x26	1x30	alicarboxylic_off	100	0	No	No	No	No	5	4
6	1x26	7x32	alicarboxylic_off	100	0	No	No	No	No	5	1
7	1x27	7x31	alicarboxylic_off	100	0	No	Yes	No	No	3	4
8	1x38	1x42	alicarboxylic_off	100	0	No	No	No	No	4	7
9	1x50	2x47	alicarboxylic_off	100	0	Yes	No	No	No	9	8
10	1x53	7x53	alicarboxylic_off	100	0	No	No	Yes	Yes	9	9
11	1x57	1x61	alicarboxylic_off	100	0	Yes	No	No	No	7	6
12	1x57	I1	alicarboxylic_off	100	0	Yes	No	No	No	7	6
13	1x57	7x53	alicarboxylic_off	100	0	Yes	No	Yes	Yes	7	9
14	1x57	8x50	alicarboxylic_off	100	0	Yes	No	Yes	No	7	8
15	1x60	8x57	alicarboxylic_off	100	0	No	No	No	No	5	5
16	1x61	8x50	alicarboxylic_off	100	0	No	No	Yes	No	6	8
17	2x40	I1	alicarboxylic_off	100	0	No	No	No	No	8	6
18	2x37	2x39	alicarboxylic_off	100	0	No	No	No	No	7	7
19	2x38	3x49	alicarboxylic_off	100	0	No	No	No	No	6	8
20	2x39	3x50	alicarboxylic_off	100	0	No	No	No	No	7	9
21	2x42	3x46	alicarboxylic_off	100	0	Yes	Yes	No	No	8	9
22	2x47	7x53	alicarboxylic_off	100	0	No	No	Yes	Yes	8	9
23	2x49	3x35	alicarboxylic_off	100	0	No	No	No	No	8	8
24	2x49	3x38	alicarboxylic_off	100	0	No	No	Yes	No	8	7
25	2x53	2x54	alicarboxylic_off	100	0	Yes	Yes	No	No	7	5
26	2x53	2x57	alicarboxylic_off	100	0	Yes	Yes	No	No	7	7
27	2x59	3x24	alicarboxylic_off	100	0	No	No	No	No	7	6
28	2x64	7x38	alicarboxylic_off	100	0	Yes	Yes	Yes	No	4	5
29	3x28	E1x50	alicarboxylic_off	100	0	No	No	Yes	Yes	5	8
30	3x29	E2x50	alicarboxylic_off	100	0	Yes	No	Yes	No	6	9
31	3x29	E2x52	alicarboxylic_off	100	0	Yes	No	No	No	6	5
32	3x32	7x42	alicarboxylic_off	100	0	No	No	Yes	Yes	7	7
33	3x33	4x57	alicarboxylic_off	100	0	No	No	No	No	5	6
34	3x33	4x61	alicarboxylic_off	100	0	No	No	No	No	5	3
35	3x35	7x46	alicarboxylic_off	100	0	No	No	No	No	8	8
36	3x36	6x48	alicarboxylic_off	100	0	Yes	No	Yes	Yes	7	8
37	3x36	6x51	alicarboxylic_off	100	0	Yes	No	Yes	Yes	7	6
38	3x36	7x42	alicarboxylic_off	100	0	Yes	No	Yes	Yes	7	7
39	3x37	6x55	alicarboxylic_off	100	0	Yes	Yes	Yes	Yes	7	6
40	3x38	3x42	alicarboxylic_off	100	0	Yes	No	Yes	Yes	7	7
41	3x39	7x45	alicarboxylic_off	100	0	No	No	Yes	No	9	9
42	3x43	6x40	alicarboxylic_off	100	0	No	No	No	No	8	8
43	3x43	6x44	alicarboxylic_off	100	0	No	No	Yes	Yes	8	9
44	3x43	7x52	alicarboxylic_off	100	0	No	No	Yes	No	8	7
45	3x44	5x54	alicarboxylic_off	100	0	No	No	No	No	7	8
46	3x46	6x36	alicarboxylic_off	100	0	No	No	No	Yes	9	8
47	3x47	5x54	alicarboxylic_off	100	0	No	No	No	No	9	8
48	3x47	6x37	alicarboxylic_off	100	0	No	No	No	No	9	7
49	3x49	I2x52	alicarboxylic_off	100	0	No	No	Yes	Yes	8	4
50	3x50	7x56	alicarboxylic_off	100	0	No	No	No	No	9	7
51	3x52	I2x57	alicarboxylic_off	100	0	No	No	Yes	No	5	6
52	3x55	5x64	alicarboxylic_off	100	0	No	No	No	No	8	4
53	3x56	I2x57	alicarboxylic_off	100	0	Yes	Yes	Yes	No	6	6
54	I2x54	I2x57	alicarboxylic_off	100	0	No	No	Yes	No	5	6
55	4x41	I2x56	alicarboxylic_off	100	0	Yes	No	No	No	3	2
56	4x41	4x45	alicarboxylic_off	100	0	Yes	No	No	No	3	6
57	4x56	5x43	alicarboxylic_off	100	0	No	No	Yes	No	5	5
58	4x64	4x68	alicarboxylic_off	100	0	No	No	No	No	4	2
59	4x68	E2x51	alicarboxylic_off	100	0	No	No	No	No	2	4
60	E2	E2x52	alicarboxylic_off	100	0	Yes	Yes	No	No	3	5
61	7x34	E2x52	alicarboxylic_off	100	0	Yes	Yes	No	No	5	5
62	5x39	E2	alicarboxylic_off	100	0	No	No	Yes	Yes	6	3
63	6x59	E2	alicarboxylic_off	100	0	No	No	Yes	Yes	5	3
64	5x32	5x35	alicarboxylic_off	100	0	No	No	No	No	2	3
65	5x34	5x35	alicarboxylic_off	100	0	No	No	No	No	1	3
66	5x37	5x41	alicarboxylic_off	100	0	No	No	No	No	3	4
67	5x40	6x56	alicarboxylic_off	100	0	No	No	No	No	5	5
68	5x43	6x55	alicarboxylic_off	100	0	Yes	No	Yes	Yes	5	6
69	5x44	6x56	alicarboxylic_off	100	0	No	No	No	No	5	5
70	5x45	5x49	alicarboxylic_off	100	0	No	No	No	No	4	6
71	5x51	6x41	alicarboxylic_off	100	0	No	Yes	No	No	6	8
72	5x51	6x45	alicarboxylic_off	100	0	No	Yes	No	No	6	6
73	5x58	5x62	alicarboxylic_off	100	0	No	Yes	No	No	8	6
74	5x58	6x34	alicarboxylic_off	100	0	No	Yes	No	No	8	6
75	5x62	5x66	alicarboxylic_off	100	0	No	No	No	No	6	5
76	6x39	6x43	alicarboxylic_off	100	0	No	No	No	No	6	6
77	6x44	7x45	alicarboxylic_off	100	0	Yes	Yes	Yes	No	9	9
78	6x48	6x52	alicarboxylic_off	100	0	Yes	Yes	Yes	Yes	8	8
79	6x51	7x37	alicarboxylic_off	100	0	Yes	Yes	No	No	6	7
80	6x54	6x57	alicarboxylic_off	100	0	No	No	No	No	5	5
81	6x57	7x30	alicarboxylic_off	100	0	No	No	No	No	5	5
82	6x58	7x34	alicarboxylic_off	100	0	No	No	Yes	Yes	4	5
83	6x61	7x30	alicarboxylic_off	100	0	No	No	No	No	3	5
84	6x62	7x27	alicarboxylic_off	100	0	No	No	No	No	3	3
85	7x35	7x38	alicarboxylic_off	100	0	No	No	Yes	No	4	5
86	7x53	8x50	alicarboxylic_off	100	0	Yes	Yes	Yes	No	9	8
87	8x49	8x52	alicarboxylic_off	100	0	No	No	No	No	6	5
88	8x50	8x54	alicarboxylic_off	100	0	Yes	No	No	No	8	7
89	8x51	8x55	alicarboxylic_off	100	0	No	No	No	No	8	1
90	3x29	4x65	alicarboxylic_off	50	0	Yes	No	No	No	6	4
91	7x56	8x48	alicarboxylic_off	0	0	No	No	No	No	7	4
92	1x61	8x53	alicarboxylic_off	0	0	No	No	No	No	6	4
93	1x51	1x55	alicarboxylic_off	50	0	No	No	No	No	3	4
94	1x30	7x35	alicarboxylic_off	0	0	No	No	No	No	4	4
95	7x54	8x51	alicarboxylic_off	0	0	No	Yes	No	No	7	8
96	1x58	2x44	alicarboxylic_off	50	0	No	No	Yes	Yes	4	6
97	5x61	6x34	alicarboxylic_off	0	0	Yes	No	No	No	8	6
98	6x36	7x55	alicarboxylic_off	0	0	No	Yes	No	No	8	7
99	6x47	7x43	alicarboxylic_off	0	0	No	No	No	No	9	5
100	5x65	6x31	alicarboxylic_off	0	0	No	No	No	No	8	5
101	5x58	6x38	alicarboxylic_off	0	0	No	Yes	No	No	8	4
102	7x51	7x52	alicarboxylic_off	0	0	No	No	Yes	No	6	7
103	E1x49	E1x51	alicarboxylic_off	0	0	No	No	No	No	4	3
104	5x59	5x60	alicarboxylic_off	0	0	No	No	No	No	3	4
105	6x49	6x50	alicarboxylic_off	0	0	No	No	No	No	6	9
106	1x24	1x28	alicarboxylic_off	0	0	No	No	No	No	5	4
107	5x55	6x41	alicarboxylic_off	0	0	No	No	No	No	5	8
108	3x54	6x33	alicarboxylic_off	0	0	Yes	No	No	No	8	8
109	5x61	6x33	alicarboxylic_off	0	0	Yes	No	No	No	8	8
110	5x33	6x63	alicarboxylic_off	0	0	No	No	No	No	1	2
111	1x36	2x61	alicarboxylic_off	0	0	No	No	No	No	5	7
112	5x67	5x68	alicarboxylic_off	50	0	No	No	No	No	5	5
113	5x61	6x37	alicarboxylic_off	0	0	Yes	No	No	No	8	7
114	1x56	8x50	alicarboxylic_off	0	0	No	No	Yes	No	7	8
115	3x24	3x27	alicarboxylic_off	0	0	No	No	No	No	6	5
116	4x57	4x62	alicarboxylic_off	0	0	No	No	No	No	6	4
117	1x52	8x54	alicarboxylic_off	0	0	No	No	No	No	5	7
118	3x26	E2	alicarboxylic_off	0	0	No	No	Yes	Yes	7	3
119	3x22	3x23	alicarboxylic_off	0	0	No	No	No	No	3	3
120	4x39	4x43	alicarboxylic_off	0	0	No	No	No	No	3	3
121	5x34	5x38	alicarboxylic_off	0	0	No	No	No	No	1	3
122	6x32	6x35	alicarboxylic_off	0	0	No	No	No	No	7	6
123	4x41	4x44	alicarboxylic_off	0	0	Yes	No	No	No	3	3
124	8x51	8x52	alicarboxylic_off	0	0	No	No	No	No	8	5
125	1x23	7x28	alicarboxylic_off	0	0	Yes	No	No	Yes	3	4
126	3x21	E2	alicarboxylic_off	0	0	No	No	Yes	Yes	8	3
127	4x39	4x40	alicarboxylic_off	0	0	No	No	No	No	3	4
128	4x64	4x67	alicarboxylic_off	0	0	No	No	No	No	4	5
129	1x20	E3	alicarboxylic_off	0	0	No	No	No	Yes	5	7
130	2x52	3x31	alicarboxylic_off	0	0	No	No	No	No	6	6
131	5x38	5x42	alicarboxylic_off	0	0	No	No	No	No	3	3
132	1x47	2x55	alicarboxylic_off	0	0	No	No	No	No	6	5
133	6x38	6x42	alicarboxylic_off	0	0	No	No	No	No	4	5
134	1x41	1x45	alicarboxylic_off	0	0	No	No	No	No	5	5
135	3x26	4x66	alicarboxylic_off	0	0	No	No	No	No	7	4
136	4x47	4x51	alicarboxylic_off	0	0	No	No	No	No	4	4
137	3x56	I2x50	alicarboxylic_off	0	0	Yes	Yes	No	No	6	8
138	1x44	1x48	alicarboxylic_off	0	0	No	No	No	No	5	5
139	4x55	4x59	alicarboxylic_off	0	0	No	No	No	No	4	4
140	1x43	1x44	alicarboxylic_off	0	0	No	No	No	No	7	5
141	6x32	8x47	alicarboxylic_off	0	0	No	No	No	No	7	8
142	5x37	6x60	alicarboxylic_off	0	0	No	No	No	No	3	4
143	8x55	8x58	alicarboxylic_off	0	0	No	No	No	No	1	5
144	2x67	Lig	alicarboxylic_off	0	0	No	No	Yes	Yes	4	0
145	1x39	Lig	Shared	100	100	Yes	Yes	Yes	Yes	8	0
146	2x60	Lig	Shared	100	100	No	No	Yes	Yes	6	0
147	2x64	Lig	Shared	100	100	Yes	Yes	Yes	Yes	4	0
148	3x29	Lig	Shared	100	100	Yes	No	Yes	Yes	6	0
149	3x32	Lig	Shared	100	100	No	No	Yes	Yes	7	0
150	7x38	Lig	Shared	100	100	Yes	No	Yes	Yes	5	0
151	7x42	Lig	Shared	100	100	Yes	Yes	Yes	Yes	7	0
152	1x20	7x25	Shared	100	25	No	No	No	No	5	4
153	1x22	1x23	Shared	100	50	No	No	Yes	No	8	3
154	1x23	7x29	Shared	100	100	Yes	No	No	No	3	4
155	1x24	7x28	Shared	100	0	No	No	No	Yes	5	4
156	1x27	7x28	Shared	100	50	No	Yes	No	Yes	3	4
157	1x31	2x64	Shared	100	100	No	No	Yes	Yes	2	4
158	1x32	1x33	Shared	100	100	No	No	No	No	4	5
159	1x34	1x38	Shared	100	100	No	No	No	No	5	4
160	1x34	7x36	Shared	100	100	No	No	No	No	5	5
161	1x34	7x39	Shared	100	100	No	No	No	No	5	5
162	1x35	1x39	Shared	100	100	No	No	Yes	Yes	6	8
163	1x35	2x64	Shared	100	100	No	No	Yes	Yes	6	4
164	1x38	7x39	Shared	100	100	No	No	No	No	4	5
165	1x39	2x57	Shared	100	100	Yes	Yes	No	No	8	7
166	1x39	7x39	Shared	100	100	Yes	Yes	No	No	8	5
167	1x43	1x47	Shared	100	100	No	No	No	No	7	6
168	1x43	2x58	Shared	100	100	No	No	No	No	7	9
169	1x46	2x54	Shared	100	50	No	No	No	No	8	5
170	1x47	2x54	Shared	100	25	No	No	No	No	6	5
171	1x50	2x50	Shared	100	100	Yes	No	No	Yes	9	9
172	1x50	7x50	Shared	100	100	Yes	No	No	No	9	9
173	1x51	2x51	Shared	100	0	No	No	No	No	3	7
174	1x54	2x44	Shared	100	50	No	No	Yes	Yes	7	6
175	1x57	2x40	Shared	100	50	Yes	No	No	No	7	8
176	1x57	2x44	Shared	100	100	Yes	No	Yes	Yes	7	6
177	2x44	I1	Shared	100	100	Yes	Yes	No	No	6	6
178	2x37	2x40	Shared	100	100	No	No	No	No	7	8
179	2x37	I2x52	Shared	100	100	No	No	Yes	Yes	7	4
180	2x39	3x49	Shared	100	100	No	No	No	No	7	8
181	2x42	3x45	Shared	100	100	Yes	Yes	No	No	8	7
182	2x42	4x42	Shared	100	33.3333	Yes	Yes	No	No	8	7
183	2x42	4x45	Shared	100	100	Yes	Yes	No	No	8	6
184	2x43	7x53	Shared	100	50	No	No	Yes	Yes	8	9
185	2x44	2x48	Shared	100	100	Yes	Yes	No	No	6	6
186	2x45	3x42	Shared	100	100	No	No	Yes	Yes	9	7
187	2x45	4x46	Shared	100	100	No	No	No	No	9	8
188	2x45	4x50	Shared	100	100	No	No	No	Yes	9	9
189	2x46	7x49	Shared	100	100	No	No	No	Yes	9	9
190	2x50	7x46	Shared	100	100	No	Yes	No	No	9	8
191	2x50	7x49	Shared	100	100	No	Yes	No	Yes	9	9
192	2x53	3x35	Shared	100	100	Yes	Yes	No	No	7	8
193	2x53	7x42	Shared	100	100	Yes	Yes	Yes	Yes	7	7
194	2x53	7x46	Shared	100	100	Yes	Yes	No	No	7	8
195	2x56	3x28	Shared	100	100	No	No	No	No	6	5
196	2x59	E1x52	Shared	100	100	No	No	Yes	Yes	7	7
197	2x59	3x28	Shared	100	100	No	No	No	No	7	5
198	2x62	2x66	Shared	100	100	No	No	No	No	4	4
199	2x62	E1x52	Shared	100	100	No	No	Yes	Yes	4	7
200	2x63	E1x50	Shared	100	100	No	No	Yes	Yes	5	8
201	E1x50	E1x52	Shared	100	100	Yes	Yes	Yes	Yes	8	7
202	E1x50	E2x50	Shared	100	100	Yes	Yes	Yes	No	8	9
203	3x24	E1x52	Shared	100	100	No	No	Yes	Yes	6	7
204	3x22	E2	Shared	100	50	No	No	Yes	Yes	3	3
205	3x25	E2x50	Shared	100	100	No	No	Yes	No	9	9
206	3x30	3x34	Shared	100	100	No	Yes	No	No	5	5
207	3x30	4x54	Shared	100	100	No	Yes	No	No	5	4
208	3x33	E2	Shared	100	100	No	No	Yes	Yes	5	3
209	3x36	3x37	Shared	100	100	Yes	No	Yes	Yes	7	7
210	3x37	5x43	Shared	100	100	Yes	Yes	Yes	No	7	5
211	3x37	6x52	Shared	100	100	Yes	Yes	Yes	Yes	7	8
212	3x38	4x50	Shared	100	100	Yes	No	No	Yes	7	9
213	3x38	4x53	Shared	100	100	Yes	No	No	No	7	7
214	3x40	5x50	Shared	100	50	No	No	No	No	8	9
215	3x40	6x44	Shared	100	100	No	No	Yes	Yes	8	9
216	3x40	6x48	Shared	100	100	No	No	Yes	Yes	8	8
217	3x41	4x49	Shared	100	100	No	No	No	No	5	7
218	3x42	4x46	Shared	100	100	Yes	Yes	No	No	7	8
219	3x42	4x49	Shared	100	100	Yes	Yes	No	No	7	7
220	3x42	4x50	Shared	100	100	Yes	Yes	No	Yes	7	9
221	3x45	4x45	Shared	100	100	No	No	No	No	7	6
222	3x48	5x57	Shared	100	100	No	No	No	No	7	8
223	3x51	3x55	Shared	100	100	Yes	Yes	No	No	8	8
224	3x51	5x57	Shared	100	100	Yes	Yes	No	No	8	8
225	3x51	5x60	Shared	100	100	Yes	Yes	No	No	8	4
226	3x51	5x61	Shared	100	33.3333	Yes	Yes	Yes	No	8	8
227	3x53	I2x52	Shared	100	100	No	No	Yes	Yes	7	4
228	3x54	5x61	Shared	100	100	Yes	No	Yes	No	8	8
229	3x54	5x64	Shared	100	100	Yes	No	No	No	8	4
230	3x54	5x65	Shared	100	50	Yes	No	No	No	8	8
231	3x55	3x56	Shared	100	100	No	No	Yes	Yes	8	6
232	3x56	I2x54	Shared	100	100	Yes	Yes	No	No	6	5
233	I2x51	I2x53	Shared	100	100	No	No	No	No	5	6
234	I2x52	I2x57	Shared	100	50	Yes	Yes	Yes	No	4	6
235	4x52	4x56	Shared	100	0	No	No	No	No	5	5
236	4x56	5x46	Shared	100	0	No	No	No	No	5	4
237	4x60	5x39	Shared	100	100	No	No	No	No	8	6
238	4x61	E2	Shared	100	100	No	No	Yes	Yes	3	3
239	4x64	E2	Shared	100	66.6667	No	No	Yes	Yes	4	3
240	4x68	E2	Shared	100	0	No	No	Yes	Yes	2	3
241	E2	E2	Shared	100	100	Yes	Yes	Yes	Yes	3	3
242	E2	E2x51	Shared	100	100	Yes	Yes	No	No	3	4
243	6x55	E2	Shared	100	100	Yes	Yes	Yes	Yes	6	3
244	6x58	E2	Shared	100	100	No	No	Yes	Yes	4	3
245	7x34	E2	Shared	100	100	Yes	Yes	Yes	Yes	5	3
246	5x32	5x33	Shared	100	50	No	No	No	No	2	1
247	5x33	6x62	Shared	100	100	No	No	No	No	1	3
248	5x36	6x59	Shared	100	100	No	No	No	No	4	5
249	5x39	5x43	Shared	100	100	No	No	Yes	No	6	5
250	5x40	6x55	Shared	100	100	No	No	Yes	Yes	5	6
251	5x41	6x56	Shared	100	100	No	No	No	No	4	5
252	5x44	6x52	Shared	100	100	No	No	Yes	Yes	5	8
253	5x47	6x48	Shared	100	100	Yes	Yes	Yes	Yes	8	8
254	5x47	6x52	Shared	100	100	Yes	Yes	Yes	Yes	8	8
255	5x56	5x57	Shared	100	100	No	No	No	No	5	8
256	5x56	5x60	Shared	100	100	No	No	No	No	5	4
257	5x59	5x63	Shared	100	100	No	No	No	No	3	3
258	5x64	5x68	Shared	100	100	No	No	No	No	4	5
259	6x36	7x52	Shared	100	8.33333	No	Yes	Yes	No	8	7
260	6x39	7x52	Shared	100	66.6667	No	No	Yes	No	6	7
261	6x44	6x48	Shared	100	100	Yes	Yes	Yes	Yes	9	8
262	6x48	7x45	Shared	100	100	Yes	Yes	Yes	No	8	9
263	6x51	6x52	Shared	100	100	Yes	Yes	Yes	Yes	6	8
264	6x51	6x55	Shared	100	100	Yes	Yes	Yes	Yes	6	6
265	6x52	6x55	Shared	100	100	Yes	Yes	Yes	Yes	8	6
266	6x54	7x37	Shared	100	100	No	No	No	No	5	7
267	6x55	7x34	Shared	100	100	Yes	Yes	Yes	Yes	6	5
268	6x58	7x31	Shared	100	100	No	No	No	No	4	4
269	7x34	7x38	Shared	100	100	Yes	Yes	Yes	No	5	5
270	7x45	7x49	Shared	100	100	Yes	No	No	Yes	9	9
271	7x54	8x50	Shared	100	100	No	Yes	Yes	No	7	8
272	2x66	E1x49	Shared	0	50	No	No	No	No	4	4
273	3x37	5x461	Shared	0	100	Yes	Yes	No	No	7	5
274	6x61	7x27	Shared	0	100	No	No	No	No	3	3
275	2x41	4x42	Shared	50	100	No	No	No	No	6	7
276	6x54	7x33	Shared	0	58.3333	No	No	No	No	5	5
277	1x50	2x51	Shared	0	100	Yes	No	No	No	9	7
278	3x30	4x62	Shared	50	25	No	Yes	No	No	5	4
279	6x51	7x41	Shared	0	100	Yes	Yes	No	No	6	8
280	1x42	7x43	Shared	50	100	No	No	No	No	7	5
281	5x47	6x49	Shared	0	100	Yes	Yes	No	No	8	6
282	5x47	5x48	Shared	0	100	Yes	Yes	No	No	8	4
283	5x47	5x51	Shared	0	100	Yes	Yes	No	Yes	8	6
284	6x50	7x37	Shared	0	100	No	No	No	No	9	7
285	5x49	5x50	Shared	0	25	No	No	No	No	6	9
286	6x50	7x40	Shared	0	8.33333	No	No	No	No	9	8
287	1x55	1x59	Shared	0	50	No	No	No	No	4	4
288	2x56	3x31	Shared	0	50	No	No	No	No	6	6
289	3x44	5x53	Shared	0	100	No	No	No	No	7	6
290	4x41	I2x55	Shared	0	50	Yes	No	No	No	3	3
291	2x41	4x43	Shared	0	50	No	No	No	No	6	3
292	6x49	6x53	Shared	0	0	No	No	No	No	6	6
293	1x29	1x33	Shared	0	0	No	No	No	No	4	5
294	7x43	7x48	Shared	0	100	No	No	No	No	5	5
295	4x38	4x40	Shared	0	8.33333	No	No	No	No	7	4
296	1x45	7x47	Shared	0	100	No	No	No	No	5	8
297	1x39	2x61	Shared	0	50	Yes	Yes	No	No	8	7
298	1x42	7x47	Shared	0	100	No	No	No	No	7	8
299	1x56	1x60	Shared	0	25	No	No	No	No	7	5
300	1x40	2x61	Shared	0	33.3333	No	No	No	No	5	7
301	1x36	2x65	Shared	0	25	No	No	No	No	5	4
302	6x32	6x33	Shared	0	0	No	No	No	No	7	8
303	4x59	4x60	Shared	0	100	No	No	No	No	4	8
304	6x42	6x46	Shared	0	8.33333	No	No	No	No	5	6
305	7x26	7x30	Shared	0	0	No	No	No	No	1	5
306	4x51	4x55	Shared	0	0	No	No	No	No	4	4
307	I2x50	I2x51	Shared	0	50	No	No	No	No	8	5
308	1x49	7x50	Shared	0	50	No	No	No	No	7	9
309	3x33	Lig	alicarboxylic_on	0	100	No	No	Yes	Yes	5	0
310	E2x52	Lig	alicarboxylic_on	0	100	No	No	Yes	Yes	5	0
311	E2	Lig	alicarboxylic_on	0	100	Yes	Yes	Yes	Yes	3	0
312	1x39	7x42	alicarboxylic_on	0	100	Yes	Yes	Yes	Yes	8	7
313	1x42	7x42	alicarboxylic_on	0	100	No	No	Yes	Yes	7	7
314	1x53	7x54	alicarboxylic_on	0	100	No	No	No	Yes	9	7
315	1x57	7x54	alicarboxylic_on	0	100	Yes	No	No	Yes	7	7
316	2x38	I2x57	alicarboxylic_on	0	100	No	No	Yes	No	6	6
317	2x46	3x43	alicarboxylic_on	0	100	No	No	No	No	9	8
318	2x49	4x50	alicarboxylic_on	0	100	No	No	No	Yes	8	9
319	2x50	3x39	alicarboxylic_on	0	100	No	Yes	No	No	9	9
320	2x52	3x35	alicarboxylic_on	0	100	No	No	No	No	6	8
321	2x53	3x32	alicarboxylic_on	0	100	Yes	Yes	No	No	7	7
322	2x56	3x32	alicarboxylic_on	0	100	No	No	No	No	6	7
323	2x59	E1x50	alicarboxylic_on	0	100	No	No	Yes	Yes	7	8
324	2x60	2x64	alicarboxylic_on	0	100	No	No	Yes	Yes	6	4
325	3x25	E1x50	alicarboxylic_on	0	100	No	No	Yes	Yes	9	8
326	E1x51	E1x52	alicarboxylic_on	0	100	No	No	Yes	Yes	3	7
327	3x30	4x57	alicarboxylic_on	0	100	No	Yes	No	No	5	6
328	3x30	4x61	alicarboxylic_on	0	100	No	Yes	No	No	5	3
329	3x43	7x53	alicarboxylic_on	0	100	No	No	Yes	Yes	8	9
330	3x44	5x50	alicarboxylic_on	0	100	No	No	No	No	7	9
331	3x45	4x49	alicarboxylic_on	0	100	No	No	No	No	7	7
332	3x46	3x50	alicarboxylic_on	0	100	No	No	No	No	9	9
333	3x47	5x58	alicarboxylic_on	0	100	No	No	No	Yes	9	8
334	3x50	5x58	alicarboxylic_on	0	100	No	No	No	Yes	9	8
335	3x50	7x53	alicarboxylic_on	0	100	No	No	Yes	Yes	9	9
336	3x52	3x56	alicarboxylic_on	0	100	No	No	Yes	Yes	5	6
337	4x38	4x41	alicarboxylic_on	0	100	No	No	Yes	No	7	3
338	4x64	5x35	alicarboxylic_on	0	100	No	No	No	No	4	3
339	6x62	E2	alicarboxylic_on	0	100	No	No	Yes	Yes	3	3
340	5x32	5x34	alicarboxylic_on	0	100	No	No	No	No	2	1
341	5x47	6x44	alicarboxylic_on	0	100	Yes	Yes	Yes	Yes	8	9
342	5x51	5x55	alicarboxylic_on	0	100	No	Yes	No	No	6	5
343	5x51	6x44	alicarboxylic_on	0	100	No	Yes	Yes	Yes	6	9
344	5x54	6x44	alicarboxylic_on	0	100	No	No	Yes	Yes	8	9
345	5x58	6x37	alicarboxylic_on	0	100	No	Yes	No	No	8	7
346	5x70	I3	alicarboxylic_on	0	100	No	No	No	Yes	0	4
347	6x31	I3	alicarboxylic_on	0	100	No	No	No	Yes	5	4
348	6x32	6x36	alicarboxylic_on	0	100	No	No	No	Yes	7	8
349	6x36	7x56	alicarboxylic_on	0	100	No	Yes	No	No	8	7
350	6x40	7x53	alicarboxylic_on	0	100	No	No	Yes	Yes	8	9
351	6x43	7x48	alicarboxylic_on	0	100	No	No	No	No	6	5
352	6x47	7x45	alicarboxylic_on	0	100	No	No	Yes	No	9	9
353	6x48	7x41	alicarboxylic_on	0	100	Yes	Yes	No	No	8	8
354	6x51	7x34	alicarboxylic_on	0	100	Yes	Yes	Yes	Yes	6	5
355	7x31	7x35	alicarboxylic_on	0	100	No	No	No	No	4	4
356	7x49	7x53	alicarboxylic_on	0	100	No	Yes	Yes	Yes	9	9
357	7x52	7x53	alicarboxylic_on	0	100	Yes	No	Yes	Yes	7	9
358	8x48	8x51	alicarboxylic_on	0	100	No	No	No	No	4	8
359	2x66	E1x51	alicarboxylic_on	0	100	No	No	No	No	4	3
360	5x40	E2	alicarboxylic_on	0	100	No	No	Yes	Yes	5	3
361	NT	NT	alicarboxylic_on	0	100	No	Yes	No	Yes	0	0
362	E3	NT	alicarboxylic_on	0	100	No	Yes	No	Yes	7	0
363	E2	NT	alicarboxylic_on	0	100	Yes	Yes	No	Yes	3	0
364	7x28	NT	alicarboxylic_on	0	100	No	Yes	No	Yes	4	0
365	2x67	NT	alicarboxylic_on	0	100	No	No	No	Yes	4	0
366	7x35	E1	alicarboxylic_on	0	100	No	No	No	No	4	0
367	3x22	3x26	alicarboxylic_on	0	100	No	No	No	No	3	7
368	3x36	Lig	alicarboxylic_on	0	100	Yes	No	Yes	Yes	7	0
369	3x49	3x53	alicarboxylic_on	0	100	No	No	No	No	8	7
370	5x44	E2	alicarboxylic_on	0	100	No	No	Yes	Yes	5	3
371	5x41	6x55	alicarboxylic_on	0	100	No	No	Yes	Yes	4	6
372	5x41	6x59	alicarboxylic_on	0	100	No	No	No	No	4	5
373	E3	E3	alicarboxylic_on	0	100	No	Yes	No	Yes	7	7
374	7x27	E3	alicarboxylic_on	0	100	No	No	No	Yes	3	7
375	7x28	E3	alicarboxylic_on	0	100	No	Yes	No	Yes	4	7
376	2x43	7x54	alicarboxylic_on	0	50	No	No	No	Yes	8	7
377	3x26	4x65	alicarboxylic_on	0	50	No	No	No	No	7	4
378	6x54	7x34	alicarboxylic_on	0	50	No	No	Yes	Yes	5	5
379	3x22	4x67	alicarboxylic_on	0	50	No	No	No	No	3	5
380	5x69	I3	alicarboxylic_on	0	75	No	No	No	Yes	0	4
381	I2x54	I2x56	alicarboxylic_on	0	50	No	No	No	No	5	2
382	1x55	1x60	alicarboxylic_on	0	50	No	No	No	No	4	5
383	5x68	5x71	alicarboxylic_on	0	50	No	No	No	No	5	0
384	5x62	6x34	alicarboxylic_on	0	50	No	No	No	No	6	6
385	3x52	I2x52	alicarboxylic_on	0	50	No	No	Yes	Yes	5	4
386	1x46	7x47	alicarboxylic_on	0	66.6667	No	No	No	No	8	8
387	6x60	6x64	alicarboxylic_on	0	50	No	No	No	No	4	0
388	1x55	8x57	alicarboxylic_on	0	50	No	No	No	No	4	5
389	8x49	8x53	alicarboxylic_on	0	50	No	No	No	No	6	4
390	6x58	7x30	alicarboxylic_on	0	50	No	No	No	No	4	5
391	1x27	7x32	alicarboxylic_on	0	50	No	Yes	No	No	3	1
392	5x65	6x30	alicarboxylic_on	0	41.6667	No	No	No	No	8	0
393	1x30	7x32	alicarboxylic_on	0	50	No	No	No	No	4	1
394	5x66	6x34	alicarboxylic_on	0	50	No	No	No	No	5	6
395	5x63	5x67	alicarboxylic_on	0	50	No	No	No	No	3	5
396	7x54	8x54	alicarboxylic_on	0	50	No	Yes	No	No	7	7
397	1x23	1x27	alicarboxylic_on	0	50	Yes	No	No	Yes	3	3
398	6x57	6x61	alicarboxylic_on	0	50	No	No	No	No	5	3
399	1x36	1x37	alicarboxylic_on	0	50	No	No	No	No	5	5
400	2x51	2x55	alicarboxylic_on	0	50	No	No	No	No	7	5
401	2x42	3x49	alicarboxylic_on	0	50	Yes	Yes	No	No	8	8
402	5x37	6x59	alicarboxylic_on	0	50	No	No	No	No	3	5
403	4x63	4x64	alicarboxylic_on	0	33.3333	No	No	No	No	5	4
404	5x58	6x41	alicarboxylic_on	0	50	No	Yes	No	No	8	8
405	3x23	3x24	alicarboxylic_on	0	50	No	No	No	No	3	6
406	3x37	4x56	alicarboxylic_on	0	50	Yes	Yes	No	No	7	5
407	2x41	4x39	alicarboxylic_on	0	16.6667	No	No	No	No	6	3
408	6x30	I3	alicarboxylic_on	0	50	No	No	No	Yes	0	4
409	6x29	I3	alicarboxylic_on	0	50	No	No	No	Yes	0	4
410	1x52	7x55	alicarboxylic_on	0	50	No	No	No	No	5	7
411	1x54	2x47	alicarboxylic_on	0	25	No	No	No	No	7	8
412	5x38	NT	alicarboxylic_on	0	50	No	No	No	Yes	3	0
413	3x53	I2x55	alicarboxylic_on	0	50	No	No	No	No	7	3
414	6x45	6x49	alicarboxylic_on	0	8.33333	No	No	No	No	6	6
415	5x62	6x37	alicarboxylic_on	0	50	No	No	No	No	6	7
416	6x32	8x48	alicarboxylic_on	0	16.6667	No	No	No	No	7	4
417	1x58	1x59	alicarboxylic_on	0	50	No	No	No	No	4	4
418	1x30	1x33	alicarboxylic_on	0	50	No	No	No	No	4	5
419	5x34	6x63	alicarboxylic_on	0	25	No	No	No	No	1	2
420	7x54	7x55	alicarboxylic_on	0	0	No	Yes	No	No	7	7
421	6x39	6x42	alicarboxylic_on	0	25	No	No	No	No	6	5
422	1x38	1x41	alicarboxylic_on	0	25	No	No	No	No	4	5
423	6x65	E3	alicarboxylic_on	0	50	No	No	No	Yes	0	7
424	1x48	1x49	alicarboxylic_on	0	0	No	No	No	No	5	7
425	1x44	1x45	alicarboxylic_on	0	50	No	No	No	No	5	5
426	5x51	5x52	alicarboxylic_on	0	0	No	Yes	No	No	6	3
427	3x56	I2x53	alicarboxylic_on	0	0	Yes	Yes	No	No	6	6
428	1x36	2x64	alicarboxylic_on	0	0	No	No	Yes	Yes	5	4
429	6x63	6x64	alicarboxylic_on	0	0	No	No	No	No	2	0
430	1x56	7x54	alicarboxylic_on	0	0	No	No	No	Yes	7	7
431	3x21	E1x50	alicarboxylic_on	0	0	No	No	Yes	Yes	8	8
432	5x45	5x48	alicarboxylic_on	0	25	No	No	No	No	4	4
433	8x47	8x48	alicarboxylic_on	0	16.6667	No	No	No	No	8	4
434	5x60	5x63	alicarboxylic_on	0	16.6667	No	No	No	No	4	3
435	6x34	6x38	alicarboxylic_on	0	0	No	No	No	No	6	4
436	3x23	3x27	alicarboxylic_on	0	0	No	No	No	No	3	5
437	4x51	4x54	alicarboxylic_on	0	0	No	No	No	No	4	4
438	4x66	4x67	alicarboxylic_on	0	0	No	No	No	No	4	5
439	6x35	6x36	alicarboxylic_on	0	16.6667	No	No	No	Yes	6	8
440	7x51	7x55	alicarboxylic_on	0	0	No	No	No	No	6	7
441	8x49	8x50	alicarboxylic_on	0	0	No	No	Yes	No	6	8
442	4x55	4x58	alicarboxylic_on	0	8.33333	No	No	No	No	4	0
443	5x72	I3	alicarboxylic_on	0	0	No	No	No	Yes	0	4
444	1x20	1x24	alicarboxylic_on	0	0	No	No	No	No	5	5
445	5x39	5x42	alicarboxylic_on	0	0	No	No	No	No	6	3
446	1x26	1x27	alicarboxylic_on	0	0	No	No	No	Yes	5	3
447	4x48	4x52	alicarboxylic_on	0	0	No	No	No	No	3	5
448	4x43	4x47	alicarboxylic_on	0	0	No	No	No	No	3	4
449	4x44	4x45	alicarboxylic_on	0	0	No	No	No	No	3	6
450	1x21	1x22	alicarboxylic_on	0	0	No	No	No	No	4	8
451	6x25	6x64	alicarboxylic_on	0	8.33333	No	No	No	No	0	0

Orange: nodes, hubs and links specific of alicarboxylic_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of alicarboxylic_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	alicarboxylic_off Avg Int. Strength	alicarboxylic_on Avg Int. Strength	alicarboxylic_off Num Of Links	alicarboxylic_on Num Of Links	ConSurf
1	1x23	alicarboxylic_off	0	0	4	3	3
2	1x50	alicarboxylic_off	0	0	4	3	9
3	1x57	alicarboxylic_off	100	25	6	3	7
4	3x29	alicarboxylic_off	50	0	4	1	6
5	3x36	alicarboxylic_off	100	0	4	2	7
6	3x38	alicarboxylic_off	50	0	4	2	7
7	3x54	alicarboxylic_off	0	0	4	3	8
8	I2x57	alicarboxylic_off	100	50	4	2	6
9	4x41	alicarboxylic_off	0	0	4	2	3
10	E2x50	alicarboxylic_off	50	0	4	2	9
11	5x43	alicarboxylic_off	100	0	4	2	5
12	5x61	alicarboxylic_off	0	0	5	2	8
13	7x38	alicarboxylic_off	100	25	4	2	5
14	7x45	alicarboxylic_off	100	0	4	3	9
15	7x52	alicarboxylic_off	0	0	4	3	7
16	8x50	alicarboxylic_off	100	0	6	2	8
17	Lig	Shared	100	100	11	11	0
18	1x39	Shared	100	50	5	6	8
19	2x42	Shared	100	0	4	4	8
20	2x44	Shared	100	8.33333	5	4	6
21	2x53	Shared	100	25	5	4	7
22	2x64	Shared	100	50	4	5	4
23	E1x50	Shared	100	100	5	6	8
24	E1x52	Shared	100	50	4	5	7
25	3x37	Shared	100	50	5	5	7
26	3x42	Shared	100	50	5	4	7
27	3x51	Shared	100	41.6667	4	4	8
28	3x56	Shared	0	0	4	4	6
29	I2x52	Shared	100	0	4	4	4
30	E2	Shared	100	100	16	16	3
31	5x47	Shared	0	66.6667	5	6	8
32	6x44	Shared	100	75	4	5	9
33	6x48	Shared	100	100	6	5	8
34	6x51	Shared	100	50	5	4	6
35	6x52	Shared	100	50	6	5	8
36	6x55	Shared	100	100	7	6	6
37	7x34	Shared	100	75	5	5	5
38	7x42	Shared	50	41.6667	4	4	7
39	7x53	Shared	100	66.6667	5	6	9
40	NT	alicarboxylic_on	0	50	0	7	0
41	1x27	alicarboxylic_on	0	0	2	4	3
42	2x50	alicarboxylic_on	0	50	3	4	9
43	3x30	alicarboxylic_on	0	0	3	5	5
44	4x50	alicarboxylic_on	0	25	3	4	9
45	5x51	alicarboxylic_on	0	0	3	4	6
46	5x58	alicarboxylic_on	0	50	3	4	8
47	I3	alicarboxylic_on	0	41.6667	0	6	4
48	6x36	alicarboxylic_on	0	0	3	4	8
49	E3	alicarboxylic_on	0	50	1	6	7
50	7x28	alicarboxylic_on	0	0	3	4	4
51	7x49	alicarboxylic_on	50	66.6667	3	4	9
52	7x54	alicarboxylic_on	0	100	2	7	7

Orange: nodes, hubs and links specific of alicarboxylic_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of alicarboxylic_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	alicarboxylic_off Recurrence	alicarboxylic_on Recurrence	alicarboxylic_off Hub1?	alicarboxylic_on Hub1?	alicarboxylic_off Hub2?	alicarboxylic_on Hub2?	ConSurf1	ConSurf2
1	E1x50	Lig	alicarboxylic_off	17.7282	0	Yes	Yes	Yes	Yes	8	0
2	1x23	7x28	alicarboxylic_off	12.8629	0	Yes	No	No	Yes	3	4
3	1x27	7x31	alicarboxylic_off	20.8565	0	No	Yes	No	No	3	4
4	6x58	7x31	alicarboxylic_off	22.7624	5.20167	No	No	No	No	4	4
5	6x58	7x34	alicarboxylic_off	15.6092	0	No	No	Yes	Yes	4	5
6	7x34	7x38	alicarboxylic_off	17.5191	2.50838	Yes	Yes	Yes	No	5	5
7	7x38	Lig	alicarboxylic_off	18.2147	2.74768	Yes	No	Yes	Yes	5	0
8	1x39	Lig	alicarboxylic_off	12.0466	4.51421	Yes	Yes	Yes	Yes	8	0
9	1x39	7x39	alicarboxylic_off	13.1765	3.92464	Yes	Yes	No	No	8	5
10	2x53	2x54	alicarboxylic_off	10.8524	0	Yes	Yes	No	No	7	5
11	1x50	2x50	alicarboxylic_off	100	6.30248	Yes	No	No	Yes	9	9
12	1x50	2x47	alicarboxylic_off	94.0893	0	Yes	No	No	No	9	8
13	2x47	7x53	alicarboxylic_off	93.1202	0	No	No	Yes	Yes	8	9
14	1x57	7x53	alicarboxylic_off	74.2019	0	Yes	No	Yes	Yes	7	9
15	7x53	8x50	alicarboxylic_off	16.2686	0	Yes	Yes	Yes	No	9	8
16	3x36	7x42	alicarboxylic_off	36.1319	0	Yes	No	Yes	Yes	7	7
17	3x36	6x48	alicarboxylic_off	26.3731	0	Yes	No	Yes	Yes	7	8
18	6x44	6x48	alicarboxylic_off	19.4129	1.41409	Yes	Yes	Yes	Yes	9	8
19	3x43	6x44	alicarboxylic_off	28.0177	0	No	No	Yes	Yes	8	9
20	3x43	7x52	alicarboxylic_off	25.5368	0	No	No	Yes	No	8	7
21	6x36	7x52	alicarboxylic_off	20.5871	8.5585	No	Yes	Yes	No	8	7
22	3x46	6x36	alicarboxylic_off	18.1825	0	No	No	No	Yes	9	8
23	2x42	3x46	alicarboxylic_off	16.8838	0	Yes	Yes	No	No	8	9
24	2x53	3x35	alicarboxylic_off	10.9208	1.99495	Yes	Yes	No	No	7	8
25	2x49	3x35	alicarboxylic_off	14.6723	0	No	No	No	No	8	8
26	2x49	3x38	alicarboxylic_off	13.2409	0	No	No	Yes	No	8	7
27	E1x50	E1x52	alicarboxylic_off	10.5629	0.106601	Yes	Yes	Yes	Yes	8	7
28	3x36	3x37	alicarboxylic_off	15.4564	6.36993	Yes	No	Yes	Yes	7	7
29	3x36	6x51	alicarboxylic_off	23.8641	0	Yes	No	Yes	Yes	7	6
30	6x55	7x34	alicarboxylic_off	12.7986	0.430753	Yes	Yes	Yes	Yes	6	5
31	6x48	6x52	alicarboxylic_off	47.6196	0	Yes	Yes	Yes	Yes	8	8
32	6x51	6x52	alicarboxylic_off	10.6353	0.408998	Yes	Yes	Yes	Yes	6	8
33	I2x52	I2x57	alicarboxylic_off	57.4548	2.56059	Yes	Yes	Yes	No	4	6
34	3x56	I2x57	alicarboxylic_off	53.6751	0	Yes	Yes	Yes	No	6	6
35	3x55	5x64	alicarboxylic_off	13.3092	0	No	No	No	No	8	4
36	3x37	5x43	alicarboxylic_off	14.9618	4.33799	Yes	Yes	Yes	No	7	5
37	4x60	5x39	alicarboxylic_off	15.8665	1.57725	No	No	No	No	8	6
38	6x51	7x37	alicarboxylic_off	32.887	0	Yes	Yes	No	No	6	7
39	6x54	7x37	alicarboxylic_off	30.2493	2.66066	No	No	No	No	5	7
40	6x54	6x57	alicarboxylic_off	26.2686	0	No	No	No	No	5	5
41	6x57	7x30	alicarboxylic_off	24.2622	0	No	No	No	No	5	5
42	6x61	7x30	alicarboxylic_off	20.6152	0	No	No	No	No	3	5
43	6x61	7x27	alicarboxylic_off	18.5887	3.97903	No	No	No	No	3	3
44	6x62	7x27	alicarboxylic_off	16.5581	0	No	No	No	No	3	3
45	5x61	6x34	alicarboxylic_off	10.4664	0	Yes	No	No	No	8	6
46	4x59	4x60	alicarboxylic_off	13.2167	0.931123	No	No	No	No	4	8
47	5x39	5x43	alicarboxylic_off	12.8589	3.42209	No	No	Yes	No	6	5
48	6x44	7x45	alicarboxylic_off	10.965	0	Yes	Yes	Yes	No	9	9
49	1x27	7x28	Shared	19.1998	19.0249	No	Yes	No	Yes	3	4
50	7x42	Lig	Shared	34.4712	23.3433	Yes	Yes	Yes	Yes	7	0
51	2x53	7x42	Shared	45.2312	24.355	Yes	Yes	Yes	Yes	7	7
52	2x53	7x46	Shared	37.2095	45.8469	Yes	Yes	No	No	7	8
53	2x50	7x46	Shared	41.9984	45.5989	No	Yes	No	No	9	8
54	1x57	2x40	Shared	68.7455	64.6956	Yes	No	No	No	7	8
55	2x37	2x40	Shared	68.8138	63.6906	No	No	No	No	7	8
56	2x37	I2x52	Shared	61.1178	62.642	No	No	Yes	Yes	7	4
57	2x50	7x49	Shared	62.694	43.9934	No	Yes	No	Yes	9	9
58	6x48	7x45	Shared	53.1403	63.3272	Yes	Yes	Yes	No	8	9
59	7x45	7x49	Shared	63.1122	62.6354	Yes	No	No	Yes	9	9
60	6x52	6x55	Shared	32.7463	21.492	Yes	Yes	Yes	Yes	8	6
61	3x55	3x56	Shared	48.8983	25.8017	No	No	Yes	Yes	8	6
62	3x51	3x55	Shared	34.5195	24.6138	Yes	Yes	No	No	8	8
63	3x51	5x61	Shared	23.8721	13.7275	Yes	Yes	Yes	No	8	8
64	5x33	6x62	Shared	14.5195	12.0741	No	No	No	No	1	3
65	5x32	5x33	Shared	10.4101	10.5448	No	No	No	No	2	1
66	6x55	E2	Shared	26.8758	34.4994	Yes	Yes	Yes	Yes	6	3
67	3x32	Lig	alicarboxylic_on	0.369924	26.9199	No	No	Yes	Yes	7	0
68	E2	Lig	alicarboxylic_on	0	44.0434	Yes	Yes	Yes	Yes	3	0
69	E2	NT	alicarboxylic_on	0	38.3892	Yes	Yes	No	Yes	3	0
70	7x28	NT	alicarboxylic_on	0	24.9793	No	Yes	No	Yes	4	0
71	7x49	7x53	alicarboxylic_on	0	100	No	Yes	Yes	Yes	9	9
72	2x43	7x53	alicarboxylic_on	1.51588	81.9149	No	No	Yes	Yes	8	9
73	2x43	7x54	alicarboxylic_on	0	81.4602	No	No	No	Yes	8	7
74	1x57	7x54	alicarboxylic_on	0	70.2606	Yes	No	No	Yes	7	7
75	3x53	I2x52	alicarboxylic_on	1.53197	29.1955	No	No	Yes	Yes	7	4
76	3x49	3x53	alicarboxylic_on	0	23.7654	No	No	No	No	8	7
77	2x42	3x49	alicarboxylic_on	0	21.3723	Yes	Yes	No	No	8	8
78	2x42	3x45	alicarboxylic_on	1.36711	12.0807	Yes	Yes	No	No	8	7
79	3x45	4x49	alicarboxylic_on	0	10.8776	No	No	No	No	7	7
80	2x56	3x32	alicarboxylic_on	0	14.9611	No	No	No	No	6	7
81	2x56	3x28	alicarboxylic_on	4.09731	13.4599	No	No	No	No	6	5
82	2x59	3x28	alicarboxylic_on	1.43546	12.7029	No	No	No	No	7	5
83	4x61	E2	alicarboxylic_on	1.31082	16.906	No	No	Yes	Yes	3	3
84	3x30	4x61	alicarboxylic_on	0	15.394	No	Yes	No	No	5	3
85	5x44	E2	alicarboxylic_on	0	19.1663	No	No	Yes	Yes	5	3
86	5x44	6x52	alicarboxylic_on	5.57298	19.2903	No	No	Yes	Yes	5	8
87	6x51	6x55	alicarboxylic_on	8.89023	15.803	Yes	Yes	Yes	Yes	6	6
88	6x51	7x41	alicarboxylic_on	2.07881	32.3783	Yes	Yes	No	No	6	8
89	6x48	7x41	alicarboxylic_on	0	31.9932	Yes	Yes	No	No	8	8
90	7x34	E2	alicarboxylic_on	5.9228	15.84	Yes	Yes	Yes	Yes	5	3
91	6x51	7x34	alicarboxylic_on	0	17.2649	Yes	Yes	Yes	Yes	6	5
92	5x47	6x52	alicarboxylic_on	3.50221	44.2044	Yes	Yes	Yes	Yes	8	8
93	5x47	6x48	alicarboxylic_on	7.04865	35.7416	Yes	Yes	Yes	Yes	8	8
94	3x50	7x53	alicarboxylic_on	0	11.0691	No	No	Yes	Yes	9	9
95	3x52	I2x52	alicarboxylic_on	0	33.9947	No	No	Yes	Yes	5	4
96	3x52	3x56	alicarboxylic_on	0	32.8373	No	No	Yes	Yes	5	6
97	3x54	5x61	alicarboxylic_on	0.390028	12.4918	Yes	No	Yes	No	8	8
98	7x52	7x53	alicarboxylic_on	0	13.0074	Yes	No	Yes	Yes	7	9
99	6x58	E2	alicarboxylic_on	9.17571	10.3794	No	No	Yes	Yes	4	3
100	6x62	E2	alicarboxylic_on	0	13.6101	No	No	Yes	Yes	3	3
101	2x53	3x32	alicarboxylic_on	0	23.7436	Yes	Yes	No	No	7	7

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
1x31	Lig	alicarboxylic_off	5.2	0	1	0	1	0
1x39	Lig	Shared	6.675	5.0875	0	1	1	0
2x60	Lig	Shared	10.625	5.92417	0	1	1	0
2x64	Lig	Shared	17.435	7.47917	1	1	1	0
E1x50	Lig	alicarboxylic_off	10.165	0	1	2	1	0
3x29	Lig	Shared	27.39	6.92417	1	0	1	0
3x32	Lig	Shared	11.995	7.19583	1	0	1	0
E2x50	Lig	alicarboxylic_off	4.72	0	1	2	1	0
7x38	Lig	Shared	13.855	15.3767	1	0	1	0
7x42	Lig	Shared	4.535	6.75417	1	1	1	0
1x31	2x64	Shared	11.785	6.12583	1	0	1	1
1x35	1x39	Shared	4.69	7.02417	0	0	2	1
1x35	2x64	Shared	10.55	8.49917	0	0	2	1
1x39	2x57	Shared	7.03	3.90583	0	1	1	2
1x39	7x39	Shared	11.13	5.77	0	1	1	2
2x53	2x57	alicarboxylic_off	9.74	0	1	0	2	2
2x53	7x42	Shared	15	8.82	1	0	2	1
2x56	3x28	Shared	5.85	5.0075	0	0	2	2
2x59	E1x52	Shared	16.76	7.20083	1	2	2	2
2x59	3x28	Shared	9.115	9.89167	1	2	2	2
2x63	E1x50	Shared	4.94	8.49333	0	0	2	1
2x64	7x38	alicarboxylic_off	5.14	0	1	1	1	1
E1x50	E1x52	Shared	12.54	8.29583	1	2	1	2
3x28	E1x50	alicarboxylic_off	4.52	0	0	0	2	1
E1x50	E2x50	Shared	9.14	10.6667	1	2	1	1
3x22	E2	Shared	6.8	3.48833	1	1	2	1
3x25	E2x50	Shared	7.28	4.55	0	2	2	1
3x29	E2x50	alicarboxylic_off	7.66	0	1	0	1	1
3x29	E2x52	alicarboxylic_off	5.96	0	1	0	1	1
3x32	7x42	alicarboxylic_off	7.31	0	1	0	1	1
3x33	4x57	alicarboxylic_off	6.92	0	1	1	1	2
3x33	4x61	alicarboxylic_off	11.165	0	1	1	1	2
3x33	E2	Shared	8.71	5.09	1	1	1	1
3x36	3x37	Shared	5.86	3.81	0	0	1	2
3x36	6x48	alicarboxylic_off	8.53	0	0	0	1	2
3x36	6x51	alicarboxylic_off	4.69	0	0	0	1	2
3x36	7x42	alicarboxylic_off	9.135	0	0	0	1	1
3x37	6x55	alicarboxylic_off	5.655	0	1	0	2	2
4x61	E2	Shared	7.18	5.0225	1	1	2	1
4x64	4x68	alicarboxylic_off	5.19	0	1	1	2	2
4x64	E2	Shared	6.39	3.46083	1	1	2	1
4x68	E2	Shared	5.82	1.19	1	0	2	1
4x68	E2x51	alicarboxylic_off	4.76	0	1	0	2	2
E2	E2	Shared	20.305	13.7142	1	1	1	1
E2	E2x51	Shared	9.7	9.20667	1	1	1	2
E2	E2x52	alicarboxylic_off	11.51	0	1	1	1	1
7x34	E2x52	alicarboxylic_off	8.05	0	1	1	2	1
5x39	E2	alicarboxylic_off	9.435	0	1	0	2	1
6x55	E2	Shared	11.155	5.88833	1	1	2	1
6x59	E2	alicarboxylic_off	5.67	0	1	0	2	1
6x58	E2	Shared	12.58	6.3475	1	1	2	1
7x34	E2	Shared	5.27	6.86833	1	1	2	1
5x40	6x55	Shared	11.86	4.2825	0	1	2	2
6x51	6x55	Shared	9.26	5.4025	1	1	2	2
6x55	7x34	Shared	5.14	10.7867	1	1	2	2
6x58	7x34	alicarboxylic_off	8.23	0	1	1	2	2
7x34	7x38	Shared	13.89	11.6967	1	1	2	1
7x35	7x38	alicarboxylic_off	5.635	0	0	0	2	1
3x29	4x65	alicarboxylic_off	4.385	0	1	0	1	2
1x36	2x61	alicarboxylic_off	3.1	0	0	0	2	2
3x26	E2	alicarboxylic_off	2.94	0	1	0	2	1
1x39	2x61	Shared	2.42	3.34583	0	1	1	2
3x21	E2	alicarboxylic_off	2.11	0	0	0	2	1
2x67	Lig	alicarboxylic_off	0.42	0	0	0	1	0
3x33	Lig	alicarboxylic_on	0	4.355	1	1	1	0
E2x52	Lig	alicarboxylic_on	0	7.3325	1	0	1	0
E2	Lig	alicarboxylic_on	0	4.11917	1	1	1	0
1x39	7x42	alicarboxylic_on	0	5.65167	0	1	1	1
1x42	7x42	alicarboxylic_on	0	4.56583	0	0	2	1
2x53	3x32	alicarboxylic_on	0	5.22583	1	0	2	1
2x56	3x32	alicarboxylic_on	0	5.565	0	0	2	1
2x59	E1x50	alicarboxylic_on	0	4.1175	1	2	2	1
2x60	2x64	alicarboxylic_on	0	4.00417	0	1	1	1
3x25	E1x50	alicarboxylic_on	0	7.62083	0	2	2	1
6x62	E2	alicarboxylic_on	0	5.01583	0	1	2	1
6x51	7x34	alicarboxylic_on	0	5.1275	1	1	2	2
5x40	E2	alicarboxylic_on	0	4.855	0	1	2	1
NT	NT	alicarboxylic_on	0	24.2667	0	1	2	2
E2	NT	alicarboxylic_on	0	27.2083	1	1	1	2
2x67	NT	alicarboxylic_on	0	8.215	0	0	1	2
3x22	3x26	alicarboxylic_on	0	4.8625	1	1	2	2
3x36	Lig	alicarboxylic_on	0	5.60417	0	0	1	0
5x44	E2	alicarboxylic_on	0	4.28667	0	1	2	1
3x26	4x65	alicarboxylic_on	0	3.68	1	0	2	2
1x36	2x64	alicarboxylic_on	0	1.56167	0	0	2	1
3x21	E1x50	alicarboxylic_on	0	1.40667	0	0	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	alicarboxylic_off	succinate_off
	alicarboxylic_on	succinate_on hca_on

Network Difference
Value	alicarboxylic_off	alicarboxylic_on
I_min	4.46	3.7825
Number of Linked Nodes	265	278
Number of Specific Nodes	5 (1.89%)	18 (6.47%)
Number of Shared Nodes	260 (98.11%)	260 (93.53%)
Number of Links	308	307
Number of Specific Links	144 (46.75%)	143 (46.58%)
Number of Shared Links	164 (53.25%)	164 (53.42%)
Number of Hubs	39	36
Number of Specific Hubs	16 (41.03%)	13 (36.11%)
Number of Shared Hubs	23 (58.97%)	23 (63.89%)
Average % Shared Neighbours (Jaccard)	37.69
Average % Shared Neighbours (Otsuka)	46.80
Average % Shared Neighbours (Overlap Coefficient)	54.77
Average % Shared Cliques (k3-6)	79.38
Graphlets Similarity	0.622018

Paths Difference
Value	alicarboxylic_off	alicarboxylic_on
Number Of Nodes in MetaPath	63	49
Specific Nodes in MetaPath	33 (52.38%)	19 (38.78%)
Shared Nodes in MetaPath	260 (98.11%)	260 (98.11%)
Number Of Links MetaPath	66	53
Specific Links in MetaPath	48 (72.73%)	35 (66.04%)
Shared Links in MetaPath	164 (53.25%)	164 (53.25%)
Number of Shortest Paths	52483	77275
Length Of Smallest Path	3	3
Average Path Length	14.1198	14.8736
Length of Longest Path	36	31
Minimum Path Strength	1.27	0.7325
Average Path Strength	8.21559	5.89252
Maximum Path Strength	22.4125	15.2578
Minimum Path Correlation	0.7	0.700833
Average Path Correlation	0.91028	0.900458
Maximum Path Correlation	0.99	0.9875
Minimum % Of Corr. Nodes	3.84615	3.44828
Average % Of Corr. Nodes	42.3904	34.4329
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	46.9527	47.9372
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

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Download alicarboxylic_off_on.zip<

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