psnGPCR

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Orange: nodes, hubs and links specific of alpha1_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of alpha1_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	alpha1_off Int. Strength	alpha1_on Int. Strength	alpha1_off Hub1?	alpha1_on Hub1?	alpha1_off Hub2?	alpha1_on Hub2?	ConSurf1	ConSurf2
1	1x53	7x53	alpha1_off	100	0	No	No	Yes	Yes	9	9
2	1x54	2x47	alpha1_off	100	0	No	No	No	No	7	9
3	1x60	I1x49	alpha1_off	100	0	Yes	Yes	No	No	6	6
4	2x39	3x50	alpha1_off	100	0	No	No	Yes	Yes	8	9
5	2x42	3x46	alpha1_off	100	0	Yes	Yes	No	No	8	9
6	2x42	4x46	alpha1_off	100	0	Yes	Yes	No	No	8	8
7	2x43	7x53	alpha1_off	100	0	No	No	Yes	Yes	7	9
8	2x53	2x56	alpha1_off	100	0	Yes	No	No	Yes	8	8
9	2x59	3x24	alpha1_off	100	0	No	No	No	No	5	5
10	2x63	Lig	alpha1_off	100	0	No	No	Yes	Yes	4	0
11	2x64	Lig	alpha1_off	100	0	No	No	Yes	Yes	5	0
12	3x28	Lig	alpha1_off	100	0	Yes	Yes	Yes	Yes	5	0
13	3x37	4x56	alpha1_off	100	0	No	No	No	No	7	6
14	3x39	6x44	alpha1_off	100	0	Yes	No	Yes	Yes	9	9
15	3x39	7x45	alpha1_off	100	0	Yes	No	No	No	9	9
16	3x39	7x49	alpha1_off	100	0	Yes	No	Yes	Yes	9	9
17	3x41	4x53	alpha1_off	100	0	Yes	No	No	No	6	8
18	3x41	5x50	alpha1_off	100	0	Yes	No	No	No	6	9
19	3x49	3x50	alpha1_off	100	0	Yes	Yes	Yes	Yes	9	9
20	3x50	I3	alpha1_off	100	0	Yes	Yes	Yes	No	9	3
21	3x51	5x61	alpha1_off	100	0	Yes	No	No	No	8	9
22	4x60	5x42	alpha1_off	100	0	No	No	No	No	7	5
23	5x36	E2	alpha1_off	100	0	No	No	Yes	Yes	6	4
24	5x39	Lig	alpha1_off	100	0	Yes	Yes	Yes	Yes	8	0
25	5x58	I3	alpha1_off	100	0	No	Yes	Yes	No	9	3
26	5x71	I3	alpha1_off	100	0	No	No	Yes	No	4	3
27	5x72	I3	alpha1_off	100	0	No	No	Yes	No	6	3
28	5x76	I3	alpha1_off	100	0	No	No	Yes	No	2	3
29	I3	I3	alpha1_off	100	0	Yes	No	Yes	No	3	3
30	6x39	7x52	alpha1_off	100	0	No	No	No	No	7	8
31	6x43	7x52	alpha1_off	100	0	No	No	No	No	7	8
32	6x48	6x51	alpha1_off	100	0	Yes	Yes	Yes	Yes	8	7
33	7x34	Lig	alpha1_off	100	0	Yes	No	Yes	Yes	4	0
34	7x49	7x53	alpha1_off	100	0	Yes	Yes	Yes	Yes	9	9
35	7x54	8x54	alpha1_off	100	0	No	No	Yes	No	7	7
36	Lig	Lig	alpha1_off	100	0	Yes	Yes	Yes	Yes	0	0
37	E3	Lig	alpha1_off	100	0	Yes	Yes	Yes	Yes	3	0
38	E2	Lig	alpha1_off	100	0	Yes	Yes	Yes	Yes	4	0
39	E2x51	Lig	alpha1_off	100	0	No	No	Yes	Yes	5	0
40	7x31	Lig	alpha1_off	100	0	No	No	Yes	Yes	2	0
41	E2x52	Lig	alpha1_off	100	0	No	No	Yes	Yes	6	0
42	E1x49	Lig	alpha1_off	100	0	No	No	Yes	Yes	4	0
43	2x45	3x42	alpha1_off	100	0	No	No	No	No	9	7
44	2x551	3x31	alpha1_off	100	0	No	No	No	No	6	5
45	3x21	E2	alpha1_off	100	0	No	No	Yes	Yes	8	4
46	3x48	5x57	alpha1_off	100	0	No	No	No	No	6	6
47	I2x50	I2x51	alpha1_off	100	0	No	No	No	No	8	7
48	I2x52	I2x56	alpha1_off	100	0	No	No	No	No	5	5
49	4x52	4x56	alpha1_off	100	0	No	No	No	No	5	6
50	6x40	7x49	alpha1_off	100	0	No	No	Yes	Yes	8	9
51	6x44	7x45	alpha1_off	100	0	Yes	Yes	No	No	9	9
52	6x48	7x42	alpha1_off	100	0	Yes	Yes	Yes	Yes	8	7
53	7x34	E3	alpha1_off	100	0	Yes	No	Yes	Yes	4	3
54	NT	NT	alpha1_off	100	0	No	No	No	No	0	0
55	1x42	1x46	alpha1_off	100	0	Yes	No	No	No	7	8
56	4x39	I1x48	alpha1_off	100	0	No	No	No	No	4	7
57	4x39	I1x51	alpha1_off	100	0	No	No	No	No	4	8
58	2x59	3x27	alpha1_off	100	0	No	No	No	No	5	5
59	I2x51	I3	alpha1_off	100	0	No	No	Yes	No	7	3
60	6x30	I2x53	alpha1_off	100	0	No	No	Yes	Yes	0	7
61	4x40	4x43	alpha1_off	100	0	No	No	No	No	5	5
62	7x34	E2x52	alpha1_off	100	0	Yes	No	No	No	4	6
63	5x68	6x27	alpha1_off	100	0	No	No	Yes	No	7	0
64	5x69	6x31	alpha1_off	100	0	No	No	No	No	5	0
65	6x26	6x29	alpha1_off	100	0	No	No	No	No	0	0
66	6x29	6x30	alpha1_off	100	0	No	No	No	No	0	0
67	7x35	7x39	alpha1_off	100	0	No	No	Yes	Yes	5	6
68	7x43	7x47	alpha1_off	100	0	No	No	No	No	5	6
69	6x54	7x34	alpha1_off	50	0	No	No	Yes	No	5	4
70	3x22	3x26	alpha1_off	75	0	No	No	No	No	5	6
71	1x43	1x47	alpha1_off	50	0	No	No	Yes	No	5	6
72	1x57	2x40	alpha1_off	50	0	No	No	No	No	8	8
73	5x58	6x38	alpha1_off	50	0	No	Yes	No	No	9	0
74	5x51	6x45	alpha1_off	50	0	No	No	No	No	6	5
75	5x45	5x49	alpha1_off	50	0	No	No	No	No	4	5
76	6x60	E3	alpha1_off	50	0	No	No	Yes	Yes	5	3
77	3x34	4x54	alpha1_off	50	0	No	No	No	No	6	4
78	8x52	8x56	alpha1_off	50	0	No	No	No	No	5	5
79	1x42	7x47	alpha1_off	50	0	Yes	No	No	No	7	6
80	3x50	6x33	alpha1_off	50	0	Yes	Yes	No	No	9	0
81	1x50	2x47	alpha1_off	50	0	No	Yes	No	No	9	9
82	3x26	4x61	alpha1_off	50	0	No	No	No	No	6	5
83	6x39	7x56	alpha1_off	50	0	No	No	No	No	7	7
84	1x30	1x33	alpha1_off	50	0	No	No	No	No	4	6
85	3x29	Lig	alpha1_off	50	0	No	No	Yes	Yes	6	0
86	2x37	2x38	alpha1_off	50	0	No	No	No	No	7	7
87	3x51	5x64	alpha1_off	50	0	Yes	No	No	No	8	6
88	3x43	5x54	alpha1_off	25	0	No	Yes	Yes	No	8	8
89	5x72	6x27	alpha1_off	50	0	No	No	Yes	No	6	0
90	2x49	3x39	alpha1_off	50	0	No	No	Yes	No	8	9
91	5x70	I3	alpha1_off	50	0	No	No	Yes	No	5	3
92	2x38	4x42	alpha1_off	50	0	No	No	No	No	7	7
93	5x54	6x41	alpha1_off	50	0	Yes	No	No	No	8	8
94	6x40	7x52	alpha1_off	0	0	No	No	No	No	8	8
95	5x74	I3	alpha1_off	50	0	No	No	Yes	No	4	3
96	1x47	2x55	alpha1_off	50	0	Yes	No	No	No	6	5
97	3x50	6x34	alpha1_off	50	0	Yes	Yes	No	No	9	0
98	2x41	4x42	alpha1_off	50	0	No	No	No	No	5	7
99	I2x56	I2x57	alpha1_off	25	0	No	No	Yes	Yes	5	6
100	1x47	1x51	alpha1_off	0	0	Yes	No	No	No	6	4
101	1x42	1x43	alpha1_off	50	0	Yes	No	No	No	7	5
102	1x44	1x45	alpha1_off	50	0	No	No	No	No	4	5
103	3x50	6x37	alpha1_off	50	0	Yes	Yes	No	No	9	0
104	1x33	1x37	alpha1_off	0	0	No	No	No	No	6	5
105	6x36	7x53	alpha1_off	50	0	No	No	Yes	Yes	0	9
106	4x64	5x38	alpha1_off	50	0	No	No	No	No	6	5
107	4x62	E2	alpha1_off	50	0	No	No	Yes	Yes	4	4
108	8x55	8x59	alpha1_off	50	0	No	No	No	No	5	5
109	2x57	2x58	alpha1_off	0	0	No	No	No	No	8	9
110	1x53	8x54	alpha1_off	50	0	No	No	Yes	No	9	7
111	5x65	6x31	alpha1_off	0	0	No	No	No	No	8	0
112	1x48	1x52	alpha1_off	0	0	No	No	Yes	No	4	7
113	6x43	6x46	alpha1_off	0	0	No	No	No	No	7	5
114	3x22	3x23	alpha1_off	0	0	No	No	No	No	5	3
115	7x53	8x50	alpha1_off	25	0	Yes	Yes	No	No	9	8
116	6x29	6x32	alpha1_off	0	0	No	No	No	No	0	0
117	2x41	4x43	alpha1_off	0	0	No	No	No	No	5	5
118	5x67	5x71	alpha1_off	0	0	No	No	No	No	5	4
119	1x52	8x57	alpha1_off	0	0	Yes	No	No	No	7	6
120	5x63	5x67	alpha1_off	25	0	No	No	No	No	4	5
121	5x70	5x75	alpha1_off	25	0	No	No	No	No	5	2
122	5x70	5x73	alpha1_off	25	0	No	No	No	No	5	4
123	1x36	1x39	alpha1_off	0	0	No	No	Yes	Yes	6	7
124	7x47	7x51	alpha1_off	0	0	No	No	No	No	6	6
125	4x47	4x51	alpha1_off	0	0	No	No	No	No	4	4
126	7x36	7x37	alpha1_off	0	0	No	No	No	No	5	5
127	6x32	6x35	alpha1_off	0	0	No	No	No	No	0	0
128	1x38	1x42	alpha1_off	0	0	No	No	Yes	No	5	7
129	6x27	6x28	alpha1_off	0	0	Yes	No	No	No	0	0
130	1x31	NT	alpha1_off	0	0	No	No	No	No	3	0
131	5x62	5x63	alpha1_off	0	0	No	Yes	No	No	5	4
132	7x55	7x56	alpha1_off	0	0	No	No	No	No	5	7
133	7x54	8x51	alpha1_off	0	0	No	No	No	No	7	8
134	4x44	4x48	alpha1_off	0	0	No	No	No	No	3	2
135	8x55	8x58	alpha1_off	0	0	No	No	No	No	5	7
136	1x39	7x39	Shared	100	100	Yes	Yes	Yes	Yes	7	6
137	1x45	7x51	Shared	100	100	No	No	No	No	5	6
138	1x49	7x50	Shared	100	75	No	No	No	No	9	9
139	1x50	2x50	Shared	100	100	No	Yes	Yes	Yes	9	9
140	1x50	7x50	Shared	100	100	No	Yes	No	No	9	9
141	1x51	2x51	Shared	100	100	No	No	No	No	4	7
142	1x52	8x54	Shared	100	50	Yes	No	Yes	No	7	7
143	1x56	8x54	Shared	100	25	No	No	Yes	No	8	7
144	1x57	2x44	Shared	100	100	No	No	No	No	8	6
145	1x60	I1x50	Shared	100	100	Yes	Yes	Yes	Yes	6	8
146	1x60	8x53	Shared	100	25	Yes	Yes	No	No	6	7
147	I1x48	I1x51	Shared	100	50	No	No	No	No	7	8
148	I1x49	I1x50	Shared	100	25	No	No	Yes	Yes	6	8
149	2x40	I1x50	Shared	100	100	No	No	Yes	Yes	8	8
150	2x37	2x40	Shared	100	100	No	No	No	No	7	8
151	2x38	I2x57	Shared	100	100	No	No	Yes	Yes	7	6
152	2x39	3x49	Shared	100	100	No	No	Yes	Yes	8	9
153	2x42	3x45	Shared	100	100	Yes	Yes	No	No	8	7
154	2x42	3x49	Shared	100	100	Yes	Yes	Yes	Yes	8	9
155	2x45	4x46	Shared	100	100	No	No	No	No	9	8
156	2x45	4x50	Shared	100	100	No	No	No	No	9	9
157	2x50	3x39	Shared	100	100	Yes	Yes	Yes	No	9	9
158	2x50	7x49	Shared	100	100	Yes	Yes	Yes	Yes	9	9
159	2x53	3x35	Shared	100	100	Yes	No	No	No	8	6
160	2x53	7x46	Shared	100	100	Yes	No	No	No	8	9
161	2x56	3x32	Shared	100	100	No	Yes	No	No	8	7
162	2x57	7x42	Shared	100	100	No	No	Yes	Yes	8	7
163	2x59	3x28	Shared	100	100	No	No	Yes	Yes	5	5
164	2x60	3x28	Shared	100	100	No	No	Yes	Yes	7	5
165	2x63	E1x50	Shared	100	100	No	No	Yes	Yes	4	8
166	2x64	7x35	Shared	100	100	No	No	No	No	5	5
167	2x64	7x39	Shared	100	100	No	No	Yes	Yes	5	6
168	E1x49	E1x51	Shared	100	25	No	No	No	No	4	3
169	E1x50	E1x52	Shared	100	100	Yes	Yes	No	No	8	5
170	3x28	E1x50	Shared	100	100	Yes	Yes	Yes	Yes	5	8
171	E1x50	E2x50	Shared	100	100	Yes	Yes	No	No	8	9
172	3x22	E2	Shared	100	100	No	No	Yes	Yes	5	4
173	3x25	E2x50	Shared	100	100	No	No	No	No	9	9
174	3x32	7x42	Shared	100	100	No	No	Yes	Yes	7	7
175	3x32	Lig	Shared	100	100	No	No	Yes	Yes	7	0
176	3x33	4x57	Shared	100	100	No	No	No	No	6	8
177	3x33	Lig	Shared	100	100	No	No	Yes	Yes	6	0
178	3x34	4x57	Shared	100	100	No	No	No	No	6	8
179	3x36	6x48	Shared	100	100	No	No	Yes	Yes	6	8
180	3x36	Lig	Shared	100	100	No	No	Yes	Yes	6	0
181	3x37	4x53	Shared	100	100	No	No	No	No	7	8
182	3x37	5x461	Shared	100	100	No	No	No	No	7	6
183	3x38	4x50	Shared	100	100	No	No	No	No	8	9
184	3x38	4x53	Shared	100	50	No	No	No	No	8	8
185	3x40	5x50	Shared	100	50	No	No	No	No	8	9
186	3x40	6x44	Shared	100	100	No	No	Yes	Yes	8	9
187	3x41	4x52	Shared	100	100	Yes	No	No	No	6	5
188	3x43	6x44	Shared	100	100	No	Yes	Yes	Yes	8	9
189	3x44	5x53	Shared	100	100	No	No	No	No	6	6
190	3x47	5x54	Shared	100	100	No	No	Yes	No	9	8
191	3x49	I2x53	Shared	100	100	Yes	Yes	Yes	Yes	9	7
192	3x49	I2x57	Shared	100	100	Yes	Yes	Yes	Yes	9	6
193	3x51	3x55	Shared	100	100	Yes	No	No	No	8	7
194	3x51	5x57	Shared	100	100	Yes	No	No	No	8	6
195	3x53	I2x53	Shared	100	100	No	No	Yes	Yes	8	7
196	3x54	5x61	Shared	100	50	No	No	No	No	8	9
197	3x55	3x56	Shared	100	100	No	No	No	No	7	6
198	I2x53	I2x54	Shared	100	100	Yes	Yes	No	No	7	6
199	I2x53	I2x57	Shared	100	100	Yes	Yes	Yes	Yes	7	6
200	4x38	4x41	Shared	100	50	No	No	No	No	7	6
201	4x57	4x58	Shared	100	50	No	No	No	No	8	4
202	4x59	4x60	Shared	100	100	No	No	No	No	7	7
203	4x60	5x39	Shared	100	100	No	No	Yes	Yes	7	8
204	E2	E2	Shared	100	100	Yes	Yes	Yes	Yes	4	4
205	5x39	E2	Shared	100	100	Yes	Yes	Yes	Yes	8	4
206	5x39	5x43	Shared	100	100	Yes	Yes	No	No	8	7
207	5x40	6x59	Shared	100	100	No	No	No	No	6	5
208	5x44	6x52	Shared	100	0	No	No	Yes	Yes	7	7
209	5x47	5x48	Shared	100	100	Yes	Yes	No	No	8	6
210	5x47	6x49	Shared	100	100	Yes	Yes	No	Yes	8	7
211	5x47	6x52	Shared	100	100	Yes	Yes	Yes	Yes	8	7
212	6x44	6x48	Shared	100	100	Yes	Yes	Yes	Yes	9	8
213	6x47	7x45	Shared	100	100	No	No	No	No	8	9
214	6x48	6x52	Shared	100	100	Yes	Yes	Yes	Yes	8	7
215	6x48	7x41	Shared	100	100	Yes	Yes	No	No	8	7
216	6x51	6x52	Shared	100	100	Yes	Yes	Yes	Yes	7	7
217	6x51	6x55	Shared	100	100	Yes	Yes	No	No	7	7
218	6x51	7x38	Shared	100	100	Yes	Yes	No	Yes	7	6
219	6x51	Lig	Shared	100	100	Yes	Yes	Yes	Yes	7	0
220	6x52	Lig	Shared	100	100	Yes	Yes	Yes	Yes	7	0
221	6x55	6x56	Shared	100	100	No	No	No	No	7	6
222	6x61	E3	Shared	100	100	No	No	Yes	Yes	4	3
223	E3	E3	Shared	100	100	Yes	Yes	Yes	Yes	3	3
224	7x38	7x42	Shared	100	100	No	Yes	Yes	Yes	6	7
225	7x38	Lig	Shared	100	100	No	Yes	Yes	Yes	6	0
226	7x39	7x42	Shared	100	100	Yes	Yes	Yes	Yes	6	7
227	8x47	8x50	Shared	100	100	No	No	No	No	8	8
228	1x47	2x54	Shared	100	50	Yes	No	No	No	6	7
229	2x46	7x49	Shared	100	100	No	No	Yes	Yes	9	9
230	2x50	7x46	Shared	100	100	Yes	Yes	No	No	9	9
231	2x52	3x35	Shared	100	50	No	No	No	No	6	6
232	2x53	7x42	Shared	100	100	Yes	No	Yes	Yes	8	7
233	3x51	5x60	Shared	100	100	Yes	No	No	No	8	6
234	5x51	5x55	Shared	100	100	No	No	No	No	6	5
235	7x30	7x33	Shared	100	0	No	No	No	No	5	5
236	7x43	7x48	Shared	100	25	No	No	No	No	5	6
237	1x31	1x34	Shared	100	0	No	No	No	No	3	4
238	2x41	4x39	Shared	100	100	No	No	No	No	5	4
239	5x62	5x66	Shared	100	100	No	Yes	No	No	5	5
240	6x26	6x30	Shared	100	50	No	No	No	No	0	0
241	6x27	6x31	Shared	100	25	Yes	No	No	No	0	0
242	6x57	E3	Shared	100	100	No	No	Yes	Yes	5	3
243	6x58	E3	Shared	100	100	No	No	Yes	Yes	4	3
244	7x33	E3	Shared	75	0	No	No	Yes	Yes	5	3
245	5x47	5x51	Shared	50	100	Yes	Yes	No	No	8	6
246	5x41	6x60	Shared	50	25	No	No	No	No	6	5
247	5x49	5x50	Shared	50	100	No	No	No	No	5	9
248	6x50	7x40	Shared	50	25	No	No	No	No	9	7
249	6x49	6x50	Shared	50	50	No	Yes	No	No	7	9
250	3x41	4x49	Shared	50	100	Yes	No	No	No	6	6
251	I2x52	I2x55	Shared	50	0	No	No	No	No	5	4
252	5x36	5x37	Shared	0	100	No	No	No	No	6	4
253	2x54	2x57	Shared	0	100	No	No	No	No	7	8
254	3x47	5x57	Shared	50	100	No	No	No	No	9	6
255	1x31	1x35	Shared	50	25	No	No	No	No	3	5
256	1x54	2x48	Shared	0	25	No	No	No	No	7	6
257	1x60	8x56	Shared	50	25	Yes	Yes	No	No	6	5
258	6x51	7x37	Shared	25	100	Yes	Yes	No	No	7	5
259	1x51	1x55	Shared	0	0	No	No	No	No	4	4
260	3x44	5x54	Shared	0	25	No	No	Yes	No	6	8
261	3x52	I2x57	Shared	50	100	No	No	Yes	Yes	5	6
262	2x55	2x551	Shared	50	100	No	No	No	No	5	6
263	4x64	5x39	Shared	50	100	No	No	Yes	Yes	6	8
264	1x52	8x58	Shared	50	25	Yes	No	No	No	7	7
265	2x66	E1x49	Shared	50	100	Yes	Yes	No	No	5	4
266	8x49	I1x50	Shared	50	50	No	No	Yes	Yes	7	8
267	5x40	6x55	Shared	50	100	No	No	No	No	6	7
268	6x25	6x26	Shared	50	0	No	No	No	No	0	0
269	6x49	6x53	Shared	50	100	No	Yes	No	No	7	6
270	2x42	4x45	Shared	0	0	Yes	Yes	No	No	8	6
271	3x30	4x61	Shared	0	25	No	No	No	No	6	5
272	4x40	4x44	Shared	50	25	No	No	No	No	5	3
273	1x59	1x60	Shared	0	100	No	No	Yes	Yes	5	6
274	2x62	2x66	Shared	25	100	No	No	Yes	Yes	5	5
275	1x35	1x39	Shared	25	0	No	No	Yes	Yes	5	7
276	5x56	5x60	Shared	0	100	No	No	No	No	4	6
277	4x38	4x40	Shared	0	0	No	No	No	No	7	5
278	5x45	5x46	Shared	0	25	No	No	No	No	4	5
279	1x39	2x61	Shared	0	50	Yes	Yes	No	No	7	6
280	2x65	2x66	Shared	0	0	No	No	Yes	Yes	5	5
281	1x40	1x41	Shared	0	0	No	No	No	No	3	5
282	8x48	8x51	Shared	25	25	No	No	No	No	5	8
283	2x66	2x67	Shared	0	0	Yes	Yes	No	No	5	4
284	1x32	2x65	Shared	0	0	No	No	No	No	4	5
285	7x30	7x32	Shared	0	100	No	No	No	No	5	1
286	6x41	6x42	Shared	0	0	No	No	No	No	8	5
287	1x40	1x43	Shared	0	25	No	No	No	No	3	5
288	4x62	4x63	Shared	0	50	No	No	No	No	4	5
289	4x43	4x47	Shared	0	0	No	No	No	No	5	4
290	1x43	2x57	alpha1_on	0	100	No	No	No	No	5	8
291	1x46	7x47	alpha1_on	0	100	No	No	No	No	8	6
292	1x53	7x54	alpha1_on	0	100	No	No	No	No	9	7
293	1x57	I1x50	alpha1_on	0	100	No	No	Yes	Yes	8	8
294	2x38	2x42	alpha1_on	0	100	No	No	Yes	Yes	7	8
295	2x40	8x50	alpha1_on	0	100	No	No	No	No	8	8
296	2x46	2x50	alpha1_on	0	100	No	No	Yes	Yes	9	9
297	2x46	3x43	alpha1_on	0	100	No	No	No	Yes	9	8
298	2x56	3x28	alpha1_on	0	100	No	Yes	Yes	Yes	8	5
299	2x59	E1x52	alpha1_on	0	100	No	No	No	No	5	5
300	2x60	7x39	alpha1_on	0	100	No	No	Yes	Yes	7	6
301	2x60	7x42	alpha1_on	0	100	No	No	Yes	Yes	7	7
302	3x21	E1x50	alpha1_on	0	100	No	No	Yes	Yes	8	8
303	3x25	E1x50	alpha1_on	0	100	No	No	Yes	Yes	9	8
304	3x40	6x48	alpha1_on	0	100	No	No	Yes	Yes	8	8
305	3x43	7x49	alpha1_on	0	100	No	Yes	Yes	Yes	8	9
306	3x43	7x53	alpha1_on	0	100	No	Yes	Yes	Yes	8	9
307	3x46	3x50	alpha1_on	0	100	No	No	Yes	Yes	9	9
308	3x46	7x53	alpha1_on	0	100	No	No	Yes	Yes	9	9
309	3x47	5x58	alpha1_on	0	100	No	No	No	Yes	9	9
310	3x50	5x58	alpha1_on	0	100	Yes	Yes	No	Yes	9	9
311	3x50	7x53	alpha1_on	0	100	Yes	Yes	Yes	Yes	9	9
312	3x50	7x56	alpha1_on	0	100	Yes	Yes	No	No	9	7
313	3x56	I2x52	alpha1_on	0	100	No	No	No	No	6	5
314	4x60	E2	alpha1_on	0	100	No	No	Yes	Yes	7	4
315	4x64	5x36	alpha1_on	0	100	No	No	No	No	6	6
316	E2	E2x51	alpha1_on	0	100	Yes	Yes	No	No	4	5
317	E2	E2x52	alpha1_on	0	100	Yes	Yes	No	No	4	6
318	5x43	Lig	alpha1_on	0	100	No	No	Yes	Yes	7	0
319	5x47	6x44	alpha1_on	0	100	Yes	Yes	Yes	Yes	8	9
320	5x47	6x48	alpha1_on	0	100	Yes	Yes	Yes	Yes	8	8
321	5x54	6x44	alpha1_on	0	100	Yes	No	Yes	Yes	8	9
322	5x58	6x40	alpha1_on	0	100	No	Yes	No	No	9	8
323	5x58	6x41	alpha1_on	0	100	No	Yes	No	No	9	8
324	5x62	6x34	alpha1_on	0	100	No	Yes	No	No	5	0
325	5x66	6x30	alpha1_on	0	100	No	No	No	No	5	0
326	5x67	6x29	alpha1_on	0	100	No	No	No	No	5	0
327	6x48	7x45	alpha1_on	0	100	Yes	Yes	No	No	8	9
328	6x48	Lig	alpha1_on	0	100	Yes	Yes	Yes	Yes	8	0
329	6x54	7x37	alpha1_on	0	100	No	No	No	No	5	5
330	6x57	6x61	alpha1_on	0	100	No	No	No	No	5	4
331	7x30	7x31	alpha1_on	0	100	No	No	No	No	5	2
332	7x42	Lig	alpha1_on	0	100	Yes	Yes	Yes	Yes	7	0
333	7x45	7x49	alpha1_on	0	100	No	No	Yes	Yes	9	9
334	7x52	7x53	alpha1_on	0	100	No	No	Yes	Yes	8	9
335	5x58	6x37	alpha1_on	0	100	No	Yes	No	No	9	0
336	6x59	6x60	alpha1_on	0	100	No	No	No	No	5	5
337	2x43	8x50	alpha1_on	0	50	No	No	No	No	7	8
338	1x50	2x51	alpha1_on	0	25	No	Yes	No	No	9	7
339	1x53	2x47	alpha1_on	0	50	No	No	No	No	9	9
340	1x43	2x58	alpha1_on	0	50	No	No	No	No	5	9
341	7x48	7x52	alpha1_on	0	25	No	No	No	No	6	8
342	5x461	6x52	alpha1_on	0	50	No	No	Yes	Yes	6	7
343	6x43	7x48	alpha1_on	0	75	No	No	No	No	7	6
344	2x42	4x42	alpha1_on	0	50	Yes	Yes	No	No	8	7
345	6x60	6x61	alpha1_on	0	25	No	No	No	No	5	4
346	3x54	5x64	alpha1_on	0	50	No	No	No	No	8	6
347	2x37	2x39	alpha1_on	0	50	No	No	No	No	7	8
348	2x551	2x56	alpha1_on	0	50	No	No	No	Yes	6	8
349	4x56	5x43	alpha1_on	0	25	No	No	No	No	6	7
350	3x42	3x45	alpha1_on	0	50	No	No	No	No	7	7
351	3x45	4x49	alpha1_on	0	75	No	No	No	No	7	6
352	3x37	3x41	alpha1_on	0	25	No	No	Yes	No	7	6
353	5x61	6x37	alpha1_on	0	25	No	No	No	No	9	0
354	6x45	6x49	alpha1_on	0	50	No	No	No	Yes	5	7
355	3x23	3x24	alpha1_on	0	50	No	No	No	No	3	5
356	3x48	5x53	alpha1_on	0	0	No	No	No	No	6	6
357	4x56	5x42	alpha1_on	0	25	No	No	No	No	6	5
358	2x56	3x31	alpha1_on	0	50	No	Yes	No	No	8	5
359	3x26	E2	alpha1_on	0	25	No	No	Yes	Yes	6	4
360	7x34	7x38	alpha1_on	0	25	Yes	No	No	Yes	4	6
361	5x67	5x68	alpha1_on	0	25	No	No	No	No	5	7
362	2x49	4x50	alpha1_on	0	0	No	No	No	No	8	9
363	3x52	I2x56	alpha1_on	0	50	No	No	No	No	5	5
364	I2x51	I2x52	alpha1_on	0	25	No	No	No	No	7	5
365	5x62	6x37	alpha1_on	0	0	No	Yes	No	No	5	0
366	5x64	5x67	alpha1_on	0	50	No	No	No	No	6	5
367	4x62	4x64	alpha1_on	0	25	No	No	No	No	4	6
368	6x32	6x36	alpha1_on	0	25	No	No	No	No	0	0
369	1x53	7x50	alpha1_on	0	0	No	No	No	No	9	9
370	E1x49	E2	alpha1_on	0	25	No	No	Yes	Yes	4	4
371	2x38	4x39	alpha1_on	0	25	No	No	No	No	7	4
372	1x54	2x51	alpha1_on	0	25	No	No	No	No	7	7
373	3x24	E1x52	alpha1_on	0	25	No	No	No	No	5	5
374	4x58	4x61	alpha1_on	0	50	No	No	No	No	4	5
375	I1x48	I1x50	alpha1_on	0	25	No	No	Yes	Yes	7	8
376	6x31	6x35	alpha1_on	0	25	No	No	No	No	0	0
377	5x65	6x33	alpha1_on	0	0	No	No	No	No	8	0
378	7x36	7x40	alpha1_on	0	25	No	No	No	No	5	7
379	4x54	4x58	alpha1_on	0	0	No	No	No	No	4	4
380	3x26	3x27	alpha1_on	0	25	No	No	No	No	6	5
381	5x45	5x48	alpha1_on	0	0	No	No	No	No	4	6
382	4x39	4x43	alpha1_on	0	0	No	No	No	No	4	5
383	4x48	4x52	alpha1_on	0	0	No	No	No	No	2	5
384	1x45	1x46	alpha1_on	0	0	No	No	No	No	5	8
385	8x57	8x58	alpha1_on	0	25	No	No	No	No	6	7
386	3x56	I2x50	alpha1_on	0	0	No	No	No	No	6	8
387	5x62	6x33	alpha1_on	0	0	No	Yes	No	No	5	0
388	1x48	1x49	alpha1_on	0	0	No	No	No	No	4	9
389	1x56	8x53	alpha1_on	0	25	No	No	No	No	8	7
390	5x38	5x41	alpha1_on	0	0	No	No	No	No	5	6
391	1x46	1x50	alpha1_on	0	0	No	No	No	Yes	8	9
392	6x39	6x40	alpha1_on	0	0	No	No	No	No	7	8
393	6x35	6x39	alpha1_on	0	25	No	No	No	No	0	7
394	8x51	8x55	alpha1_on	0	25	No	No	No	No	8	5
395	8x52	8x55	alpha1_on	0	25	No	No	No	No	5	5
396	1x36	2x65	alpha1_on	0	0	No	No	No	No	6	5
397	6x38	6x41	alpha1_on	0	0	No	No	No	No	0	8
398	1x41	1x44	alpha1_on	0	0	No	No	No	No	5	4
399	7x55	8x51	alpha1_on	0	25	No	No	No	No	5	8
400	1x37	1x38	alpha1_on	0	0	No	No	No	No	5	5
401	4x54	4x55	alpha1_on	0	0	No	No	No	No	4	4
402	1x33	1x34	alpha1_on	0	0	No	No	No	No	6	4
403	5x63	5x68	alpha1_on	0	0	No	No	No	No	4	7
404	1x42	7x43	alpha1_on	0	0	Yes	No	No	No	7	5
405	3x28	3x29	alpha1_on	0	0	Yes	Yes	No	No	5	6
406	6x46	6x47	alpha1_on	0	0	No	No	No	No	5	8
407	6x36	6x40	alpha1_on	0	0	No	No	No	No	0	8
408	6x25	6x28	alpha1_on	0	0	No	No	No	No	0	0
409	1x38	1x39	alpha1_on	0	0	No	No	Yes	Yes	5	7
410	5x59	5x60	alpha1_on	0	0	No	No	No	No	3	6
411	8x49	8x52	alpha1_on	0	0	No	No	No	No	7	5

Orange: nodes, hubs and links specific of alpha1_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of alpha1_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	alpha1_off Avg Int. Strength	alpha1_on Avg Int. Strength	alpha1_off Num Of Links	alpha1_on Num Of Links	ConSurf
1	1x42	alpha1_off	0	0	4	1	7
2	1x47	alpha1_off	0	0	4	1	6
3	1x52	alpha1_off	0	0	4	2	7
4	2x53	alpha1_off	50	50	4	3	8
5	3x39	alpha1_off	25	0	5	1	9
6	3x41	alpha1_off	25	0	4	3	6
7	3x51	alpha1_off	50	50	5	3	8
8	5x54	alpha1_off	0	0	4	3	8
9	I3	alpha1_off	50	0	10	0	3
10	7x34	alpha1_off	0	0	4	1	4
11	8x54	alpha1_off	25	0	4	2	7
12	6x27	alpha1_off	50	0	4	1	0
13	1x39	Shared	0	0	4	4	7
14	1x60	Shared	25	0	5	4	6
15	I1x50	Shared	25	75	4	6	8
16	2x42	Shared	75	50	5	5	8
17	2x50	Shared	25	100	4	5	9
18	2x66	Shared	0	0	4	4	5
19	E1x50	Shared	50	75	4	6	8
20	3x28	Shared	75	25	4	5	5
21	3x49	Shared	50	50	5	4	9
22	3x50	Shared	50	50	6	4	9
23	I2x53	Shared	100	75	5	4	7
24	I2x57	Shared	0	50	5	4	6
25	E2	Shared	100	100	8	9	4
26	5x39	Shared	75	25	5	4	8
27	5x47	Shared	75	100	4	6	8
28	6x44	Shared	100	50	5	5	9
29	6x48	Shared	100	100	6	8	8
30	6x51	Shared	100	25	6	5	7
31	6x52	Shared	50	100	5	6	7
32	E3	Shared	75	50	9	6	3
33	7x39	Shared	0	50	4	4	6
34	7x42	Shared	100	100	6	7	7
35	7x49	Shared	50	100	5	4	9
36	7x53	Shared	50	75	5	4	9
37	Lig	Shared	100	100	20	9	0
38	1x50	alpha1_on	0	0	3	4	9
39	2x56	alpha1_on	0	50	2	4	8
40	3x43	alpha1_on	0	50	2	4	8
41	5x58	alpha1_on	0	100	2	5	9
42	5x62	alpha1_on	0	0	2	4	5
43	6x49	alpha1_on	0	0	3	4	7
44	7x38	alpha1_on	25	50	3	4	6

Orange: nodes, hubs and links specific of alpha1_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of alpha1_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	alpha1_off Recurrence	alpha1_on Recurrence	alpha1_off Hub1?	alpha1_on Hub1?	alpha1_off Hub2?	alpha1_on Hub2?	ConSurf1	ConSurf2
1	2x54	2x57	alpha1_off	21.3673	3.81176	No	No	No	No	7	8
2	1x47	2x54	alpha1_off	20.3587	1.90924	Yes	No	No	No	6	7
3	1x43	1x47	alpha1_off	13.1217	0	No	No	Yes	No	5	6
4	7x49	7x53	alpha1_off	18.1492	0	Yes	Yes	Yes	Yes	9	9
5	1x53	7x53	alpha1_off	12.8444	0	No	No	Yes	Yes	9	9
6	1x53	8x54	alpha1_off	11.5615	0	No	No	Yes	No	9	7
7	6x48	7x42	alpha1_off	18.6156	0	Yes	Yes	Yes	Yes	8	7
8	3x39	6x44	alpha1_off	33.616	0	Yes	No	Yes	Yes	9	9
9	3x39	7x49	alpha1_off	24.6233	0	Yes	No	Yes	Yes	9	9
10	3x40	6x44	alpha1_off	76.1647	2.15126	No	No	Yes	Yes	8	9
11	3x40	5x50	alpha1_off	75.4933	4.52437	No	No	No	No	8	9
12	3x41	5x50	alpha1_off	72.7448	0	Yes	No	No	No	6	9
13	3x41	4x53	alpha1_off	69.6369	0	Yes	No	No	No	6	8
14	3x38	4x50	alpha1_off	66.9451	8.73277	No	No	No	No	8	9
15	2x45	4x50	alpha1_off	66.1918	4.38992	No	No	No	No	9	9
16	2x45	4x46	alpha1_off	64.6662	2.19832	No	No	No	No	9	8
17	2x42	4x46	alpha1_off	63.894	0	Yes	Yes	No	No	8	8
18	3x49	I2x57	alpha1_off	32.2102	6.71597	Yes	Yes	Yes	Yes	9	6
19	2x38	I2x57	alpha1_off	27.6965	6.06387	No	No	Yes	Yes	7	6
20	2x37	2x38	alpha1_off	12.92	0	No	No	No	No	7	7
21	3x49	3x50	alpha1_off	24.2041	0	Yes	Yes	Yes	Yes	9	9
22	3x28	Lig	alpha1_off	15.8892	0	Yes	Yes	Yes	Yes	5	0
23	E1x49	Lig	alpha1_off	12.2738	0	No	No	Yes	Yes	4	0
24	3x36	Lig	alpha1_off	25.1245	1.1563	No	No	Yes	Yes	6	0
25	3x36	6x48	alpha1_off	25.5532	1.04874	No	No	Yes	Yes	6	8
26	3x43	5x54	alpha1_off	18.8583	0	No	Yes	Yes	No	8	8
27	2x38	4x42	alpha1_off	14.7702	0	No	No	No	No	7	7
28	2x41	4x42	alpha1_off	13.6166	0	No	No	No	No	5	7
29	5x39	Lig	alpha1_off	12.0374	0	Yes	Yes	Yes	Yes	8	0
30	E2	Lig	alpha1_off	17.5156	0	Yes	Yes	Yes	Yes	4	0
31	6x48	6x51	alpha1_off	29.5215	0	Yes	Yes	Yes	Yes	8	7
32	3x50	I3	alpha1_off	20.6676	0	Yes	Yes	Yes	No	9	3
33	E3	Lig	alpha1_off	15.9365	0	Yes	Yes	Yes	Yes	3	0
34	2x57	7x42	Shared	23.3657	14.9445	No	No	Yes	Yes	8	7
35	1x50	2x50	Shared	10.5875	44.3092	No	Yes	Yes	Yes	9	9
36	6x44	6x48	Shared	100	68.5782	Yes	Yes	Yes	Yes	9	8
37	3x38	4x53	Shared	67.6921	10.884	No	No	No	No	8	8
38	2x42	3x49	Shared	60.4614	60.7462	Yes	Yes	Yes	Yes	8	9
39	2x37	2x40	Shared	11.7632	46.3664	No	No	No	No	7	8
40	3x43	6x44	Shared	19.9836	28.3832	No	Yes	Yes	Yes	8	9
41	3x47	5x54	Shared	13.1375	77.6403	No	No	Yes	No	9	8
42	3x47	5x57	Shared	11.9744	27.6504	No	No	No	No	9	6
43	6x51	Lig	Shared	26.5965	23.3412	Yes	Yes	Yes	Yes	7	0
44	6x52	Lig	Shared	27.4002	43.3479	Yes	Yes	Yes	Yes	7	0
45	6x48	6x52	Shared	31.2362	43.0588	Yes	Yes	Yes	Yes	8	7
46	1x39	7x39	alpha1_on	6.17159	12.6723	Yes	Yes	Yes	Yes	7	6
47	7x39	7x42	alpha1_on	6.30713	16.4639	Yes	Yes	Yes	Yes	6	7
48	2x53	7x42	alpha1_on	9.913	20.4908	Yes	No	Yes	Yes	8	7
49	2x53	7x46	alpha1_on	8.7972	17.4454	Yes	No	No	No	8	9
50	2x50	7x46	alpha1_on	8.46939	17.2706	Yes	Yes	No	No	9	9
51	1x46	1x50	alpha1_on	0	11.395	No	No	No	Yes	8	9
52	1x50	7x50	alpha1_on	3.55229	17.0151	No	Yes	No	No	9	9
53	1x50	2x51	alpha1_on	0	14.2118	No	Yes	No	No	9	7
54	7x42	Lig	alpha1_on	0	55.0118	Yes	Yes	Yes	Yes	7	0
55	5x461	6x52	alpha1_on	0	100	No	No	Yes	Yes	6	7
56	3x37	5x461	alpha1_on	1.22297	98.5748	No	No	No	No	7	6
57	3x37	3x41	alpha1_on	0	88.2218	No	No	Yes	No	7	6
58	3x41	4x49	alpha1_on	1.22297	83.5832	Yes	No	No	No	6	6
59	3x45	4x49	alpha1_on	0	82.0101	No	No	No	No	7	6
60	2x42	3x45	alpha1_on	1.1158	78.6824	Yes	Yes	No	No	8	7
61	2x39	3x49	alpha1_on	0.851037	50.0908	No	No	Yes	Yes	8	9
62	2x37	2x39	alpha1_on	0	48.2487	No	No	No	No	7	8
63	2x40	I1x50	alpha1_on	8.25506	39.3345	No	No	Yes	Yes	8	8
64	1x60	I1x50	alpha1_on	5.00851	17.2235	Yes	Yes	Yes	Yes	6	8
65	2x38	2x42	alpha1_on	0	15.1866	No	No	Yes	Yes	7	8
66	3x37	4x53	alpha1_on	2.67604	13.0218	No	No	No	No	7	8
67	2x46	2x50	alpha1_on	0	10.1311	No	No	Yes	Yes	9	9
68	6x48	Lig	alpha1_on	0	59.6773	Yes	Yes	Yes	Yes	8	0
69	2x50	7x49	alpha1_on	3.76663	28.6723	Yes	Yes	Yes	Yes	9	9
70	6x48	7x45	alpha1_on	0	25.5664	Yes	Yes	No	No	8	9
71	7x45	7x49	alpha1_on	0	21.7143	No	No	Yes	Yes	9	9
72	2x60	3x28	alpha1_on	1.9038	24.5916	No	No	Yes	Yes	7	5
73	2x56	3x28	alpha1_on	0	19.1059	No	Yes	Yes	Yes	8	5
74	2x56	3x32	alpha1_on	2.90929	25.2639	No	Yes	No	No	8	7
75	2x59	3x28	alpha1_on	5.6988	12.8	No	No	Yes	Yes	5	5
76	3x28	E1x50	alpha1_on	7.08882	24.9345	Yes	Yes	Yes	Yes	5	8
77	5x43	Lig	alpha1_on	0	43.6975	No	No	Yes	Yes	7	0
78	5x39	5x43	alpha1_on	1.91326	38.595	Yes	Yes	No	No	8	7
79	5x39	E2	alpha1_on	0.223791	24.2084	Yes	Yes	Yes	Yes	8	4
80	E1x49	E2	alpha1_on	0	14.5479	No	No	Yes	Yes	4	4
81	2x66	E1x49	alpha1_on	9.01469	11.0992	Yes	Yes	No	No	5	4
82	3x33	Lig	alpha1_on	9.4213	15.6975	No	No	Yes	Yes	6	0
83	3x33	4x57	alpha1_on	7.62466	13.7815	No	No	No	No	6	8
84	5x54	6x44	alpha1_on	0	85.2437	Yes	No	Yes	Yes	8	9
85	3x43	7x53	alpha1_on	0	28.605	No	Yes	Yes	Yes	8	9
86	3x47	5x58	alpha1_on	0	53.5193	No	No	No	Yes	9	9
87	3x51	5x57	alpha1_on	9.62933	25.2034	Yes	No	No	No	8	6
88	3x51	3x55	alpha1_on	2.44279	15.2807	Yes	No	No	No	8	7
89	3x55	3x56	alpha1_on	1.22297	12.7664	No	No	No	No	7	6
90	6x51	6x55	alpha1_on	3.84227	46.6958	Yes	Yes	No	No	7	7
91	5x40	6x55	alpha1_on	1.93217	40.5513	No	No	No	No	6	7
92	5x40	6x59	alpha1_on	0.967661	37.4588	No	No	No	No	6	5
93	5x47	6x52	alpha1_on	7.54271	41.6672	Yes	Yes	Yes	Yes	8	7
94	5x47	6x49	alpha1_on	3.4136	15.7916	Yes	Yes	No	Yes	8	7
95	5x58	6x40	alpha1_on	0	17.116	No	Yes	No	No	9	8
96	5x58	6x37	alpha1_on	0	39.0387	No	Yes	No	No	9	0
97	5x62	6x37	alpha1_on	0	20.6185	No	Yes	No	No	5	0
98	5x62	5x66	alpha1_on	1.22297	10.8908	No	Yes	No	No	5	5
99	5x61	6x37	alpha1_on	0	17.1496	No	No	No	No	9	0
100	3x54	5x61	alpha1_on	1.22297	14.595	No	No	No	No	8	9
101	3x54	5x64	alpha1_on	0	12.5378	No	No	No	No	8	6
102	6x59	6x60	alpha1_on	0	34.3529	No	No	No	No	5	5
103	6x60	6x61	alpha1_on	0	24.9479	No	No	No	No	5	4
104	6x61	E3	alpha1_on	1.40263	18.5748	No	No	Yes	Yes	4	3
105	7x33	E3	alpha1_on	5.73662	12.9277	No	No	Yes	Yes	5	3
106	7x52	7x53	alpha1_on	0	12.8672	No	No	Yes	Yes	8	9
107	1x60	8x53	alpha1_on	0.869949	11.2672	Yes	Yes	No	No	6	7
108	7x48	7x52	alpha1_on	0	10.3193	No	No	No	No	6	8
109	3x24	E1x52	alpha1_on	0	12.8874	No	No	No	No	5	5
110	3x50	7x53	alpha1_on	0	14.7227	Yes	Yes	Yes	Yes	9	9
111	8x49	I1x50	alpha1_on	0.869949	10.4202	No	No	Yes	Yes	7	8
112	2x60	7x42	alpha1_on	0	24.7462	No	No	Yes	Yes	7	7
113	2x46	3x43	alpha1_on	0	11.6504	No	No	No	Yes	9	8
114	3x43	7x49	alpha1_on	0	10.9378	No	Yes	Yes	Yes	8	9
115	3x50	5x58	alpha1_on	0	11.4756	Yes	Yes	No	Yes	9	9
116	6x51	6x52	alpha1_on	0.274223	26.3866	Yes	Yes	Yes	Yes	7	7
117	5x47	6x44	alpha1_on	0	35.5765	Yes	Yes	Yes	Yes	8	9
118	3x32	Lig	alpha1_on	8.94219	25.3176	No	No	Yes	Yes	7	0

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
2x53	2x56	alpha1_off	6.705	0	0	0	2	2
2x56	3x32	Shared	5.475	9.1275	0	0	2	1
2x57	7x42	Shared	6.4475	9.9625	0	0	2	1
2x59	3x28	Shared	13.0275	5.5125	0	0	2	1
2x60	3x28	Shared	4.945	4.635	0	1	2	1
2x63	E1x50	Shared	4.0075	3.5075	1	0	1	2
2x63	Lig	alpha1_off	7.235	0	1	0	1	0
2x64	7x35	Shared	9.7875	7.425	1	0	1	2
2x64	7x39	Shared	6.54	4.905	1	0	1	2
2x64	Lig	alpha1_off	4.5125	0	1	0	1	0
E1x49	E1x51	Shared	3.23	2	1	2	1	2
3x28	E1x50	Shared	3.28	5.625	1	0	1	2
3x22	E2	Shared	9.77	7.965	1	0	2	1
3x28	Lig	alpha1_off	14.6125	0	1	0	1	0
3x32	7x42	Shared	9.195	10.63	1	1	1	1
3x32	Lig	Shared	10.9625	12.5075	1	1	1	0
3x33	4x57	Shared	3.635	4.0375	1	0	1	2
3x33	Lig	Shared	5.82	11.96	1	0	1	0
3x36	6x48	Shared	4.8975	5.875	1	1	1	1
3x36	Lig	Shared	3.3275	8.1225	1	1	1	0
3x40	6x44	Shared	7.2225	3.77	0	1	2	2
4x60	5x39	Shared	4.865	13.5625	0	2	2	1
E2	E2	Shared	43.86	46.16	1	2	1	1
5x36	E2	alpha1_off	12.2525	0	1	0	2	1
5x39	E2	Shared	9.3875	11.3375	1	2	1	1
5x39	5x43	Shared	11.445	7.3125	1	2	1	1
5x39	Lig	alpha1_off	3.2775	0	1	2	1	0
5x44	6x52	Shared	3.365	2.77	0	0	2	1
5x47	6x52	Shared	21.1625	19.29	0	1	2	1
6x44	6x48	Shared	10.0225	5.765	1	1	2	1
6x48	6x51	alpha1_off	6.2625	0	1	1	1	1
6x48	6x52	Shared	4.51	5.26	1	1	1	1
6x48	7x41	Shared	10.91	8.7925	1	1	1	2
6x51	6x52	Shared	6.7025	5.6275	1	1	1	1
6x51	6x55	Shared	3.7075	4.6625	1	1	1	2
6x51	7x38	Shared	6.745	6.9675	1	1	1	1
6x51	Lig	Shared	8.5775	19.86	1	1	1	0
6x52	Lig	Shared	5.04	7.2875	1	1	1	0
6x61	E3	Shared	3.4	11.725	0	3	2	1
E3	E3	Shared	6.075	12.97	1	3	1	1
7x34	Lig	alpha1_off	6.495	0	1	0	1	0
7x38	7x42	Shared	7.4575	7.22	1	1	1	1
7x38	Lig	Shared	16.0075	14.125	1	1	1	0
7x39	7x42	Shared	3.375	9.4075	1	1	2	1
E3	Lig	alpha1_off	3.81	0	1	3	1	0
E2	Lig	alpha1_off	12.465	0	1	2	1	0
E2x51	Lig	alpha1_off	7.2975	0	0	0	1	0
7x31	Lig	alpha1_off	5.5125	0	0	0	1	0
E2x52	Lig	alpha1_off	9.5	0	1	0	1	0
E1x49	Lig	alpha1_off	3.7225	0	1	2	1	0
2x53	7x42	Shared	3.81	4.3925	0	0	2	1
3x21	E2	alpha1_off	3.4775	0	0	0	2	1
6x44	7x45	alpha1_off	7.55	0	1	1	2	2
6x48	7x42	alpha1_off	4.0975	0	1	1	1	1
7x34	E3	alpha1_off	5.7775	0	1	0	1	1
7x30	7x33	Shared	6.5125	1.62	0	0	2	2
7x34	E2x52	alpha1_off	5.245	0	1	0	1	1
6x57	E3	Shared	4.935	4.6175	0	3	2	1
6x58	E3	Shared	3.63	3.875	0	0	2	1
7x35	7x39	alpha1_off	4.06	0	1	0	2	2
7x33	E3	Shared	3.09	2.21	1	3	2	1
6x54	7x34	alpha1_off	3.0225	0	0	0	2	1
3x22	3x26	alpha1_off	2.99	0	1	0	2	2
6x60	E3	alpha1_off	2.82	0	1	0	2	1
3x29	Lig	alpha1_off	2.7025	0	0	0	1	0
6x51	7x37	Shared	2.53	4.5875	1	1	1	2
4x64	5x39	Shared	2.17	4.1	0	0	2	1
2x66	E1x49	Shared	2.0525	11.43	0	0	2	1
4x62	E2	alpha1_off	1.7575	0	1	0	2	1
2x56	3x28	alpha1_on	0	5.515	0	0	2	1
2x60	7x39	alpha1_on	0	4.015	0	1	2	2
2x60	7x42	alpha1_on	0	7.3125	0	1	2	1
3x21	E1x50	alpha1_on	0	3.5175	0	0	2	2
3x40	6x48	alpha1_on	0	12.0375	0	1	2	1
4x60	E2	alpha1_on	0	11.165	0	2	2	1
4x64	5x36	alpha1_on	0	7.63	0	0	2	2
E2	E2x51	alpha1_on	0	10.67	1	2	1	1
E2	E2x52	alpha1_on	0	7.54	1	2	1	1
5x43	Lig	alpha1_on	0	6.365	0	0	1	0
5x47	6x44	alpha1_on	0	5.0925	0	1	2	2
5x47	6x48	alpha1_on	0	4.01	0	1	2	1
6x48	7x45	alpha1_on	0	9.8875	1	1	1	2
6x48	Lig	alpha1_on	0	5.8375	1	1	1	0
6x54	7x37	alpha1_on	0	6.4125	0	0	2	2
6x57	6x61	alpha1_on	0	4.0825	0	3	2	2
7x30	7x31	alpha1_on	0	5.03	0	0	2	1
7x42	Lig	alpha1_on	0	8.2175	0	1	1	0
5x461	6x52	alpha1_on	0	3.3	0	0	2	1
6x60	6x61	alpha1_on	0	3.215	1	0	2	2
4x56	5x43	alpha1_on	0	3.0975	0	0	2	1
3x26	E2	alpha1_on	0	2.7125	0	2	2	1
7x34	7x38	alpha1_on	0	2.68	1	0	1	1
4x62	4x64	alpha1_on	0	2.255	1	0	2	2
E1x49	E2	alpha1_on	0	2.1875	1	2	1	1
3x28	3x29	alpha1_on	0	0.65	1	0	1	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	alpha1_off	alpha1a_off alpha1b_off
	alpha1_on	alpha1a_on

Network Difference
Value	alpha1_off	alpha1_on
I_min	3.125	3.4925
Number of Linked Nodes	264	253
Number of Specific Nodes	13 (4.92%)	2 (0.79%)
Number of Shared Nodes	251 (95.08%)	251 (99.21%)
Number of Links	289	276
Number of Specific Links	135 (46.71%)	122 (44.20%)
Number of Shared Links	154 (53.29%)	154 (55.80%)
Number of Hubs	37	32
Number of Specific Hubs	12 (32.43%)	7 (21.88%)
Number of Shared Hubs	25 (67.57%)	25 (78.13%)
Average % Shared Neighbours (Jaccard)	42.22
Average % Shared Neighbours (Otsuka)	50.94
Average % Shared Neighbours (Overlap Coefficient)	59.96
Average % Shared Cliques (k3-6)	77.68
Graphlets Similarity	0.513052

Paths Difference
Value	alpha1_off	alpha1_on
Number Of Nodes in MetaPath	45	79
Specific Nodes in MetaPath	16 (35.56%)	50 (63.29%)
Shared Nodes in MetaPath	251 (95.08%)	251 (95.08%)
Number Of Links MetaPath	45	85
Specific Links in MetaPath	33 (73.33%)	73 (85.88%)
Shared Links in MetaPath	154 (53.29%)	154 (53.29%)
Number of Shortest Paths	52756	44097
Length Of Smallest Path	3	3
Average Path Length	13.5266	12.3334
Length of Longest Path	30	31
Minimum Path Strength	0.545	0.585
Average Path Strength	5.52914	5.99339
Maximum Path Strength	14.7063	16.1838
Minimum Path Correlation	0.7025	0.7025
Average Path Correlation	0.91584	0.907
Maximum Path Correlation	0.9875	0.985
Minimum % Of Corr. Nodes	3.84615	3.7037
Average % Of Corr. Nodes	45.4338	45.2043
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	47.6132	41.2728
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

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