psnGPCR

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Orange: nodes, hubs and links specific of alpha1a_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of alpha1a_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	alpha1a_off Int. Strength	alpha1a_on Int. Strength	alpha1a_off Hub1?	alpha1a_on Hub1?	alpha1a_off Hub2?	alpha1a_on Hub2?	ConSurf1	ConSurf2
1	2x60	Lig	alpha1a_off	2.79	0	No	No	Yes	Yes	7	0
2	2x63	Lig	alpha1a_off	10.17	0	No	No	Yes	Yes	4	0
3	2x64	Lig	alpha1a_off	3.69	0	No	No	Yes	Yes	5	0
4	3x28	Lig	alpha1a_off	7.39	0	Yes	No	Yes	Yes	5	0
5	5x461	Lig	alpha1a_off	2.79	0	No	No	Yes	Yes	6	0
6	1x30	1x33	alpha1a_off	3.1	0	No	No	No	No	4	6
7	1x39	7x39	alpha1a_off	4.56	0	No	No	No	No	7	6
8	1x49	7x50	alpha1a_off	4.06	0	No	No	No	No	9	9
9	1x53	2x47	alpha1a_off	3.39	0	No	No	No	No	9	9
10	1x53	7x53	alpha1a_off	2.52	0	No	No	No	Yes	9	9
11	1x56	8x50	alpha1a_off	2.64	0	Yes	No	Yes	Yes	8	8
12	1x57	8x50	alpha1a_off	2.62	0	No	No	Yes	Yes	8	8
13	1x60	I1x49	alpha1a_off	4.78	0	No	No	No	No	6	6
14	1x60	8x53	alpha1a_off	5.85	0	No	No	No	No	6	7
15	1x60	8x56	alpha1a_off	5.1	0	No	No	No	No	6	5
16	I1x49	I1x50	alpha1a_off	6.43	0	No	No	No	Yes	6	8
17	2x37	2x39	alpha1a_off	3.2	0	No	No	No	No	7	8
18	2x38	2x42	alpha1a_off	2.52	0	No	No	Yes	Yes	7	8
19	2x39	3x50	alpha1a_off	2.59	0	No	No	No	No	8	9
20	2x42	4x46	alpha1a_off	7.03	0	Yes	Yes	No	No	8	8
21	2x43	7x53	alpha1a_off	2.42	0	No	No	No	Yes	7	9
22	2x46	3x43	alpha1a_off	2.77	0	No	Yes	No	No	9	8
23	2x46	3x46	alpha1a_off	2.85	0	No	Yes	No	No	9	9
24	2x50	3x39	alpha1a_off	15.48	0	Yes	No	No	No	9	9
25	2x50	7x49	alpha1a_off	2.69	0	Yes	No	No	Yes	9	9
26	2x53	7x46	alpha1a_off	3	0	No	No	No	No	8	9
27	2x57	2x60	alpha1a_off	3	0	Yes	No	No	No	8	7
28	2x57	7x39	alpha1a_off	2.28	0	Yes	No	No	No	8	6
29	2x57	7x42	alpha1a_off	11.72	0	Yes	No	Yes	Yes	8	7
30	2x59	3x24	alpha1a_off	9.65	0	No	No	No	No	5	5
31	2x62	2x66	alpha1a_off	2.85	0	No	No	No	Yes	5	5
32	E1x49	E1x51	alpha1a_off	2.67	0	No	No	No	Yes	4	3
33	3x24	E1x50	alpha1a_off	4.01	0	No	No	Yes	Yes	5	8
34	3x28	E1x50	alpha1a_off	6.56	0	Yes	No	Yes	Yes	5	8
35	3x22	E2.A169	alpha1a_off	4.15	0	No	No	No	No	5	3
36	3x22	E2.P170	alpha1a_off	7.21	0	No	No	No	No	5	4
37	3x22	E2.E173	alpha1a_off	2.33	0	No	No	No	No	5	4
38	3x28	E2x50	alpha1a_off	2.61	0	Yes	No	No	No	5	9
39	3x37	3x41	alpha1a_off	2.43	0	Yes	No	Yes	No	7	6
40	3x39	7x45	alpha1a_off	6.03	0	No	No	No	No	9	9
41	3x39	7x49	alpha1a_off	7.23	0	No	No	No	Yes	9	9
42	3x40	6x44	alpha1a_off	7.54	0	No	No	Yes	Yes	8	9
43	3x41	4x52	alpha1a_off	7.97	0	Yes	No	No	No	6	5
44	3x41	4x53	alpha1a_off	3.71	0	Yes	No	Yes	No	6	8
45	3x41	5x49	alpha1a_off	2.28	0	Yes	No	No	No	6	5
46	3x41	5x50	alpha1a_off	5.4	0	Yes	No	No	No	6	9
47	3x46	I3.V234	alpha1a_off	3.07	0	No	No	No	No	9	2
48	3x47	5x54	alpha1a_off	6.19	0	No	No	No	No	9	8
49	3x48	5x53	alpha1a_off	2.94	0	No	No	No	No	6	6
50	3x50	I3.I230	alpha1a_off	2.51	0	No	No	No	No	9	4
51	3x53	I2x53	alpha1a_off	4.35	0	No	No	Yes	Yes	8	7
52	I2x53	I2x54	alpha1a_off	4.17	0	Yes	Yes	No	No	7	6
53	I2x56	I2x57	alpha1a_off	3.07	0	No	No	No	Yes	5	6
54	4x38	4x41	alpha1a_off	5.17	0	No	No	No	No	7	6
55	4x40	4x44	alpha1a_off	4.96	0	No	No	No	No	5	3
56	4x58	4x61	alpha1a_off	2.85	0	No	No	No	No	4	5
57	4x59	4x60	alpha1a_off	4.06	0	No	No	Yes	No	7	7
58	4x60	4x64	alpha1a_off	2.7	0	Yes	No	Yes	No	7	6
59	4x60	5x39	alpha1a_off	5.56	0	Yes	No	Yes	No	7	8
60	4x60	5x42	alpha1a_off	7.22	0	Yes	No	No	No	7	5
61	4x61	5x39	alpha1a_off	3.52	0	No	No	Yes	No	5	8
62	4x64	5x36	alpha1a_off	3.27	0	Yes	No	Yes	Yes	6	6
63	4x64	5x38	alpha1a_off	5.63	0	Yes	No	No	No	6	5
64	4x64	5x39	alpha1a_off	3.86	0	Yes	No	Yes	No	6	8
65	E2.P168	E2.Q167	alpha1a_off	3.16	0	No	No	No	No	4	5
66	E2.N179	E2.Q167	alpha1a_off	2.64	0	No	No	No	No	5	5
67	5x36	E2.Q167	alpha1a_off	10.19	0	Yes	Yes	No	No	6	5
68	E2.I175	E2.P170	alpha1a_off	5.08	0	No	No	No	No	5	4
69	E2.D172	E2.T174	alpha1a_off	5.78	0	No	No	No	No	3	1
70	5x36	E2.N179	alpha1a_off	10.52	0	Yes	Yes	No	No	6	5
71	5x39	E2.N179	alpha1a_off	2.33	0	Yes	No	No	No	8	5
72	5x41	6x60	alpha1a_off	4.87	0	No	No	No	No	6	5
73	5x58	5x61	alpha1a_off	4.79	0	Yes	Yes	No	No	9	9
74	5x58	I3.T231	alpha1a_off	3.75	0	Yes	Yes	No	No	9	5
75	5x58	I3.V234	alpha1a_off	5.05	0	Yes	Yes	No	No	9	2
76	5x58	I3.L235	alpha1a_off	10.55	0	Yes	Yes	No	No	9	5
77	5x61	I3.T231	alpha1a_off	3.01	0	No	No	No	No	9	5
78	5x68	5x71	alpha1a_off	2.98	0	No	No	No	No	7	4
79	5x69	5x70	alpha1a_off	2.43	0	No	No	No	No	5	5
80	5x70	I3.D224	alpha1a_off	4.07	0	No	No	No	No	5	3
81	5x71	I3.D224	alpha1a_off	4.07	0	No	No	No	No	4	3
82	5x71	I3.L227	alpha1a_off	4.15	0	No	No	No	No	4	3
83	5x72	I3.K223	alpha1a_off	12.24	0	No	No	No	No	6	3
84	5x74	I3.K223	alpha1a_off	3.06	0	No	No	No	No	4	3
85	5x76	I3.R225	alpha1a_off	16.28	0	No	No	No	No	2	1
86	5x76	I3.N226	alpha1a_off	2.63	0	No	No	No	No	2	1
87	I3.D224	I3.R228	alpha1a_off	10.72	0	No	No	No	No	3	1
88	I3.N226	I3.R225	alpha1a_off	4.82	0	No	No	No	No	1	1
89	I3.R225	I3.R229	alpha1a_off	7.46	0	No	No	No	No	1	3
90	6x44	6x45	alpha1a_off	2.62	0	Yes	Yes	No	No	9	5
91	6x44	6x48	alpha1a_off	6.01	0	Yes	Yes	Yes	Yes	9	8
92	6x48	6x51	alpha1a_off	6.01	0	Yes	Yes	Yes	Yes	8	7
93	6x51	7x37	alpha1a_off	2.62	0	Yes	Yes	No	Yes	7	5
94	6x52	6x55	alpha1a_off	2.49	0	Yes	Yes	Yes	Yes	7	7
95	6x55	6x56	alpha1a_off	3.35	0	Yes	Yes	No	No	7	6
96	E3.D300	E3.P299	alpha1a_off	3.22	0	No	No	No	No	1	2
97	E3.K302	E3.P303	alpha1a_off	3.35	0	No	No	No	No	3	4
98	7x33	E3.P303	alpha1a_off	3.53	0	No	No	No	No	5	4
99	7x34	7x38	alpha1a_off	5.36	0	No	No	No	No	4	6
100	7x35	7x38	alpha1a_off	2.48	0	No	No	No	No	5	6
101	7x53	8x50	alpha1a_off	5.16	0	No	Yes	Yes	Yes	9	8
102	2x41	I1x51	alpha1a_off	2.18	0	No	No	No	No	5	8
103	1x40	1x41	alpha1a_off	2.11	0	No	No	No	No	3	5
104	1x53	7x50	alpha1a_off	1.77	0	No	No	No	No	9	9
105	6x54	E3.P303	alpha1a_off	1.77	0	No	No	No	No	5	4
106	3x42	3x45	alpha1a_off	1.76	0	No	Yes	No	No	7	7
107	4x56	5x46	alpha1a_off	1.76	0	No	No	No	No	6	5
108	1x56	8x53	alpha1a_off	1.71	0	Yes	No	No	No	8	7
109	1x59	8x57	alpha1a_off	1.71	0	No	No	No	No	5	6
110	7x40	7x41	alpha1a_off	1.71	0	No	No	No	No	7	7
111	2x54	7x47	alpha1a_off	1.69	0	No	No	No	No	7	6
112	6x49	6x50	alpha1a_off	1.64	0	No	No	No	No	7	9
113	1x56	8x57	alpha1a_off	1.62	0	Yes	No	No	No	8	6
114	3x45	4x45	alpha1a_off	1.62	0	No	No	No	No	7	6
115	4x49	4x53	alpha1a_off	1.62	0	No	No	Yes	No	6	8
116	6x41	I3.V234	alpha1a_off	1.6	0	No	No	No	No	8	2
117	6x41	6x45	alpha1a_off	1.6	0	No	No	No	No	8	5
118	7x30	7x32	alpha1a_off	1.6	0	No	No	No	No	5	1
119	3x30	4x61	alpha1a_off	1.58	0	No	No	No	No	6	5
120	5x36	5x37	alpha1a_off	1.57	0	Yes	Yes	No	No	6	4
121	1x33	1x37	alpha1a_off	1.54	0	No	No	No	No	6	5
122	1x43	1x47	alpha1a_off	1.54	0	No	Yes	No	No	5	6
123	1x47	1x51	alpha1a_off	1.54	0	No	No	No	No	6	4
124	1x54	2x48	alpha1a_off	1.54	0	No	No	No	No	7	6
125	2x49	2x50	alpha1a_off	1.54	0	No	No	Yes	No	8	9
126	3x52	I2x57	alpha1a_off	1.54	0	No	No	No	Yes	5	6
127	6x40	7x52	alpha1a_off	1.54	0	No	No	No	No	8	8
128	1x45	1x46	alpha1a_off	1.51	0	No	No	No	Yes	5	8
129	7x56	I3.L233	alpha1a_off	1.5	0	No	No	No	No	7	6
130	3x43	6x40	alpha1a_off	1.49	0	No	No	No	No	8	8
131	3x54	5x65	alpha1a_off	1.49	0	No	No	No	No	8	8
132	3x54	I3.L227	alpha1a_off	1.49	0	No	No	No	No	8	3
133	7x48	7x51	alpha1a_off	1.47	0	No	No	No	No	6	6
134	5x53	5x57	alpha1a_off	1.46	0	No	No	No	No	6	6
135	2x67	E1x49	alpha1a_off	1.45	0	No	No	No	No	4	4
136	6x61	E3.P299	alpha1a_off	1.44	0	No	No	No	No	4	2
137	1x38	1x42	alpha1a_off	1.43	0	No	No	No	No	5	7
138	1x51	1x55	alpha1a_off	1.43	0	No	No	No	No	4	4
139	7x36	7x40	alpha1a_off	1.43	0	No	No	No	No	5	7
140	5x63	5x66	alpha1a_off	1.41	0	No	No	No	No	4	5
141	3x56	I2x50	alpha1a_off	1.39	0	No	No	No	No	6	8
142	4x43	4x47	alpha1a_off	1.38	0	No	No	No	No	5	4
143	E2.E180	E2x52	alpha1a_off	1.37	0	No	No	No	No	5	6
144	7x31	7x35	alpha1a_off	1.35	0	No	No	No	No	2	5
145	3x55	5x64	alpha1a_off	1.32	0	No	No	No	No	7	6
146	I2x52	I2x55	alpha1a_off	1.29	0	No	No	No	No	5	4
147	1x45	7x51	alpha1a_off	1.26	0	No	No	No	No	5	6
148	E3.D300	E3.F301	alpha1a_off	1.19	0	No	No	No	No	1	3
149	5x48	6x53	alpha1a_off	1.17	0	No	Yes	No	No	6	6
150	8x55	8x59	alpha1a_off	1.17	0	No	No	No	No	5	5
151	3x32	Lig	Shared	8.81	14.3567	No	No	Yes	Yes	7	0
152	3x33	Lig	Shared	4.14	14.8233	No	No	Yes	Yes	6	0
153	3x36	Lig	Shared	5.89	8.60667	No	No	Yes	Yes	6	0
154	5x43	Lig	Shared	4.18	4.64167	No	No	Yes	Yes	7	0
155	6x51	Lig	Shared	9.04	10.4083	Yes	Yes	Yes	Yes	7	0
156	6x52	Lig	Shared	4.52	3.33167	Yes	Yes	Yes	Yes	7	0
157	6x55	Lig	Shared	5.24	5.60667	Yes	Yes	Yes	Yes	7	0
158	7x38	Lig	Shared	15.81	15.99	No	No	Yes	Yes	6	0
159	7x42	Lig	Shared	4.35	9.225	Yes	Yes	Yes	Yes	7	0
160	1x33	1x34	Shared	2.85	1.47333	No	No	No	No	6	4
161	1x42	7x43	Shared	4.15	1.85333	No	No	No	No	7	5
162	1x43	2x57	Shared	4.28	4.37333	No	Yes	Yes	No	5	8
163	1x50	2x50	Shared	6.73	13.4633	No	Yes	Yes	No	9	9
164	1x50	7x50	Shared	4.89	7.33333	No	Yes	No	No	9	9
165	1x51	2x51	Shared	4.28	1.53667	No	No	No	No	4	7
166	1x52	8x54	Shared	4.87	10.76	No	Yes	No	Yes	7	7
167	1x54	2x47	Shared	3.25	2.97833	No	No	No	No	7	9
168	1x56	8x54	Shared	6.61	3.465	Yes	No	No	Yes	8	7
169	1x57	2x44	Shared	4.81	4.81	No	No	No	No	8	6
170	I1x48	I1x51	Shared	2.26	3.50833	No	No	No	No	7	8
171	8x49	I1x50	Shared	2.65	3.39167	No	Yes	No	Yes	7	8
172	2x37	2x40	Shared	6.97	2.605	No	No	No	Yes	7	8
173	2x39	3x49	Shared	4.34	4.35333	No	No	No	Yes	8	9
174	2x42	3x46	Shared	4.84	3.35167	Yes	Yes	No	No	8	9
175	2x42	3x49	Shared	2.3	3.585	Yes	Yes	No	Yes	8	9
176	2x45	4x46	Shared	4.12	5.15833	No	Yes	No	No	9	8
177	2x45	4x50	Shared	5.65	3.70833	No	Yes	No	Yes	9	9
178	2x53	2x56	Shared	4.47	3.475	No	No	No	Yes	8	8
179	2x53	3x35	Shared	6.35	6.99	No	No	No	No	8	6
180	2x55	2x551	Shared	3.2	3.43833	No	No	No	No	5	6
181	2x56	3x28	Shared	2.45	3.15667	No	Yes	Yes	No	8	5
182	2x56	3x32	Shared	2.92	7.78833	No	Yes	No	No	8	7
183	2x64	7x35	Shared	9.45	7.2	No	No	No	No	5	5
184	E1x50	E1x52	Shared	7.02	8.85333	Yes	Yes	No	Yes	8	5
185	3x25	E1x50	Shared	2.61	4.135	No	No	Yes	Yes	9	8
186	E1x50	E2x50	Shared	5.22	7.18333	Yes	Yes	No	No	8	9
187	3x25	E2x50	Shared	7.28	6.67333	No	No	No	No	9	9
188	3x32	7x42	Shared	5.75	5.75	No	No	Yes	Yes	7	7
189	3x33	4x57	Shared	4.85	5.385	No	No	No	Yes	6	8
190	3x34	4x57	Shared	6.01	7.50833	No	No	No	Yes	6	8
191	3x37	4x53	Shared	3.2	3.2	Yes	No	Yes	No	7	8
192	3x37	5x461	Shared	6.4	4.79667	Yes	No	No	No	7	6
193	3x38	4x50	Shared	5.19	8.855	No	No	No	Yes	8	9
194	3x38	4x53	Shared	3.42	3.80333	No	No	Yes	No	8	8
195	3x40	5x50	Shared	3.39	2.825	No	No	No	No	8	9
196	3x43	6x44	Shared	6.09	3.24833	No	No	Yes	Yes	8	9
197	3x44	5x53	Shared	4.91	2.72667	No	No	No	No	6	6
198	3x47	5x58	Shared	3.82	5.84	No	No	Yes	Yes	9	9
199	3x49	I2x53	Shared	5.75	7.47333	No	Yes	Yes	Yes	9	7
200	3x51	3x55	Shared	7.63	12.9	No	Yes	No	No	8	7
201	3x51	5x57	Shared	9.58	5.25667	No	Yes	No	No	8	6
202	3x54	5x61	Shared	7.61	1.715	No	No	No	No	8	9
203	3x55	3x56	Shared	2.54	1.88833	No	No	No	No	7	6
204	I2x53	I2x57	Shared	8.83	12.0033	Yes	Yes	No	Yes	7	6
205	4x57	4x58	Shared	4.64	1.98167	No	Yes	No	No	8	4
206	5x37	6x60	Shared	4.33	3.54167	No	No	No	No	4	5
207	5x40	6x55	Shared	3.04	3.995	No	No	Yes	Yes	6	7
208	5x40	6x59	Shared	9.7	2.26333	No	No	No	No	6	5
209	5x44	6x52	Shared	2.77	3.025	No	No	Yes	Yes	7	7
210	5x47	5x48	Shared	5.16	5.36	Yes	Yes	No	Yes	8	6
211	5x47	5x51	Shared	2.44	5.82	Yes	Yes	No	No	8	6
212	5x47	6x44	Shared	3.22	3.75167	Yes	Yes	Yes	Yes	8	9
213	5x47	6x49	Shared	2.44	4.645	Yes	Yes	No	No	8	7
214	5x47	6x52	Shared	13.93	16.7767	Yes	Yes	Yes	Yes	8	7
215	6x39	7x52	Shared	2.94	1.535	No	No	No	No	7	8
216	6x39	7x56	Shared	3.1	1.74667	No	No	No	No	7	7
217	6x43	7x52	Shared	3.27	5.375	No	No	No	No	7	8
218	6x47	7x45	Shared	9.45	7.87333	No	No	No	No	8	9
219	6x48	6x52	Shared	3.01	7.35	Yes	Yes	Yes	Yes	8	7
220	6x48	7x41	Shared	7.04	7.97333	Yes	Yes	No	No	8	7
221	6x48	7x45	Shared	2.26	9.605	Yes	Yes	No	No	8	9
222	6x51	6x52	Shared	3.22	3.395	Yes	Yes	Yes	Yes	7	7
223	6x51	6x55	Shared	3.73	8.425	Yes	Yes	Yes	Yes	7	7
224	6x60	6x61	Shared	3.22	1.84	No	No	No	No	5	4
225	7x39	7x42	Shared	7.72	3.215	No	No	Yes	Yes	6	7
226	7x54	8x54	Shared	7.22	8	No	No	No	Yes	7	7
227	8x47	8x50	Shared	6.61	8.25667	No	No	Yes	Yes	8	8
228	8x48	8x51	Shared	2.71	2.445	No	No	No	No	5	8
229	1x46	7x47	Shared	1.96	5.86333	No	Yes	No	No	8	6
230	3x44	5x50	Shared	1.88	2.19667	No	No	No	No	6	9
231	7x55	7x56	Shared	1.72	8.37333	No	No	No	No	5	7
232	2x46	3x42	Shared	1.71	4.715	No	Yes	No	Yes	9	7
233	2x66	2x67	Shared	1.71	1.16667	No	Yes	No	No	5	4
234	3x31	3x35	Shared	1.71	6.69833	No	No	No	No	5	6
235	1x32	2x65	Shared	1.7	2.11667	No	No	No	No	4	5
236	1x46	1x50	Shared	1.7	3.65667	No	Yes	No	Yes	8	9
237	2x57	2x58	Shared	1.64	3.10667	Yes	No	No	No	8	9
238	6x54	7x37	Shared	1.6	6.485	No	No	No	Yes	5	5
239	1x39	2x61	Shared	1.58	4.20333	No	No	No	No	7	6
240	3x37	4x56	Shared	1.52	1.52	Yes	No	No	No	7	6
241	I2x55	I2x56	Shared	1.52	0.47	No	No	No	No	4	5
242	2x65	2x66	Shared	1.49	1.77333	No	No	No	Yes	5	5
243	2x42	4x42	Shared	1.45	8.37167	Yes	Yes	No	No	8	7
244	3x34	4x54	Shared	1.38	1.58	No	No	No	No	6	4
245	4x38	4x40	Shared	1.29	2.37	No	No	No	No	7	5
246	1x36	2x61	alpha1a_on	0	3.725	No	No	No	No	6	6
247	1x46	2x54	alpha1a_on	0	3.07833	No	Yes	No	No	8	7
248	1x50	2x47	alpha1a_on	0	3.38667	No	Yes	No	No	9	9
249	1x50	2x51	alpha1a_on	0	5.42667	No	Yes	No	No	9	7
250	1x55	8x57	alpha1a_on	0	3.18833	No	No	No	No	4	6
251	1x57	2x40	alpha1a_on	0	3.20167	No	No	No	Yes	8	8
252	1x60	I1x50	alpha1a_on	0	7.75833	No	No	No	Yes	6	8
253	2x40	I1x50	alpha1a_on	0	4.34833	No	Yes	No	Yes	8	8
254	8x50	I1x50	alpha1a_on	0	12.585	Yes	Yes	No	Yes	8	8
255	2x38	I2x57	alpha1a_on	0	2.88	No	No	No	Yes	7	6
256	2x39	I2x57	alpha1a_on	0	11.875	No	No	No	Yes	8	6
257	2x41	4x42	alpha1a_on	0	4.045	No	No	No	No	5	7
258	2x42	4x45	alpha1a_on	0	6.27833	Yes	Yes	No	No	8	6
259	2x45	3x42	alpha1a_on	0	10.4617	No	Yes	No	Yes	9	7
260	2x46	7x49	alpha1a_on	0	5.035	No	Yes	No	Yes	9	9
261	2x50	7x46	alpha1a_on	0	6.62667	Yes	No	No	No	9	9
262	2x52	3x35	alpha1a_on	0	10.7583	No	No	No	No	6	6
263	2x551	3x31	alpha1a_on	0	3.69	No	No	No	No	6	5
264	2x56	7x42	alpha1a_on	0	4.62667	No	Yes	Yes	Yes	8	7
265	2x59	3x28	alpha1a_on	0	7.565	No	No	Yes	No	5	5
266	2x63	E1x50	alpha1a_on	0	3.01333	No	No	Yes	Yes	4	8
267	E1x51	E1x52	alpha1a_on	0	3.60833	No	Yes	No	Yes	3	5
268	3x24	E1x52	alpha1a_on	0	5.68	No	No	No	Yes	5	5
269	3x24	3x27	alpha1a_on	0	2.935	No	No	No	No	5	5
270	3x28	3x29	alpha1a_on	0	2.93167	Yes	No	No	No	5	6
271	3x34	4x53	alpha1a_on	0	3.50167	No	No	Yes	No	6	8
272	3x36	6x48	alpha1a_on	0	4.35167	No	No	Yes	Yes	6	8
273	3x38	3x42	alpha1a_on	0	3.02	No	No	No	Yes	8	7
274	3x40	6x48	alpha1a_on	0	9.59	No	No	Yes	Yes	8	8
275	3x41	4x49	alpha1a_on	0	4.27667	Yes	No	No	No	6	6
276	3x42	4x49	alpha1a_on	0	7.15	No	Yes	No	No	7	6
277	3x43	7x49	alpha1a_on	0	7.55167	No	No	No	Yes	8	9
278	3x43	7x53	alpha1a_on	0	9.37833	No	No	No	Yes	8	9
279	3x46	3x50	alpha1a_on	0	3.34333	No	No	No	No	9	9
280	3x48	3x52	alpha1a_on	0	5.885	No	No	No	No	6	5
281	3x49	I2x57	alpha1a_on	0	7.94167	No	Yes	No	Yes	9	6
282	3x52	I2x53	alpha1a_on	0	11.095	No	No	Yes	Yes	5	7
283	3x53	I2x57	alpha1a_on	0	4.175	No	No	No	Yes	8	6
284	4x41	I2x56	alpha1a_on	0	4.54	No	No	No	No	6	5
285	4x38	4x39	alpha1a_on	0	3.20833	No	No	No	No	7	4
286	4x58	4x59	alpha1a_on	0	8.185	No	No	No	No	4	7
287	6x55	E2x52	alpha1a_on	0	3.62667	Yes	Yes	No	No	7	6
288	5x36	E2.N206	alpha1a_on	0	7.92833	Yes	Yes	No	No	6	0
289	5x48	6x52	alpha1a_on	0	4.10833	No	Yes	Yes	Yes	6	7
290	5x55	6x41	alpha1a_on	0	2.94167	No	No	No	No	5	8
291	6x30	6x33	alpha1a_on	0	6.22	No	No	No	No	0	0
292	6x35	6x39	alpha1a_on	0	5.46167	No	No	No	No	0	7
293	6x36	7x56	alpha1a_on	0	15.73	No	No	No	No	0	7
294	6x40	7x53	alpha1a_on	0	3.155	No	No	No	Yes	8	9
295	6x48	Lig	alpha1a_on	0	4.00333	Yes	Yes	Yes	Yes	8	0
296	6x49	6x53	alpha1a_on	0	5.895	No	No	No	No	7	6
297	6x50	7x37	alpha1a_on	0	10.595	No	No	No	Yes	9	5
298	6x51	7x38	alpha1a_on	0	5.89333	Yes	Yes	No	No	7	6
299	6x54	7x34	alpha1a_on	0	5.62167	No	No	No	No	5	4
300	6x57	E3.S417	alpha1a_on	0	3.00167	No	No	No	No	5	0
301	6x58	7x30	alpha1a_on	0	3.20667	No	No	No	No	4	5
302	7x33	7x36	alpha1a_on	0	3.45	No	No	No	No	5	5
303	7x33	7x37	alpha1a_on	0	4.06	No	No	No	Yes	5	5
304	7x35	7x39	alpha1a_on	0	3.67333	No	No	No	No	5	6
305	7x38	7x42	alpha1a_on	0	8.76667	No	No	Yes	Yes	6	7
306	7x45	7x49	alpha1a_on	0	3.85833	No	No	No	Yes	9	9
307	7x52	7x53	alpha1a_on	0	3.42667	No	No	No	Yes	8	9
308	7x54	8x50	alpha1a_on	0	10.81	No	No	Yes	Yes	7	8
309	8x47	8x49	alpha1a_on	0	4.04167	No	No	No	Yes	8	7
310	8x48	8x52	alpha1a_on	0	5.64167	No	No	No	No	5	5
311	1x43	2x58	alpha1a_on	0	3.075	No	Yes	No	No	5	9
312	2x60	7x42	alpha1a_on	0	3.60333	No	No	Yes	Yes	7	7
313	3x22	3x26	alpha1a_on	0	4.05	No	No	No	No	5	6
314	3x42	4x50	alpha1a_on	0	6.34833	No	Yes	No	Yes	7	9
315	3x46	7x53	alpha1a_on	0	3.62833	No	No	No	Yes	9	9
316	3x47	5x57	alpha1a_on	0	4.30833	No	No	No	No	9	6
317	3x50	5x58	alpha1a_on	0	4.8	No	No	Yes	Yes	9	9
318	3x50	7x53	alpha1a_on	0	3.94167	No	No	No	Yes	9	9
319	3x51	3x52	alpha1a_on	0	3.215	No	Yes	No	No	8	5
320	3x51	5x60	alpha1a_on	0	4.63	No	Yes	No	No	8	6
321	5x39	E2.N206	alpha1a_on	0	5.62	Yes	No	No	No	8	0
322	5x36	5x39	alpha1a_on	0	3.75667	Yes	Yes	Yes	No	6	8
323	5x39	5x43	alpha1a_on	0	4.66333	Yes	No	No	No	8	7
324	5x44	6x56	alpha1a_on	0	3.38	No	No	No	No	7	6
325	5x45	5x48	alpha1a_on	0	3.35	No	No	No	Yes	4	6
326	5x51	6x44	alpha1a_on	0	5.35333	No	No	Yes	Yes	6	9
327	5x54	6x44	alpha1a_on	0	5.39	No	No	Yes	Yes	8	9
328	5x58	6x37	alpha1a_on	0	4.885	Yes	Yes	No	No	9	0
329	5x58	6x40	alpha1a_on	0	3.57833	Yes	Yes	No	No	9	8
330	5x60	5x63	alpha1a_on	0	3.505	No	No	No	No	6	4
331	5x62	5x66	alpha1a_on	0	4.77667	No	No	No	No	5	5
332	5x62	6x34	alpha1a_on	0	4.78667	No	No	No	No	5	0
333	5x65	6x33	alpha1a_on	0	3.69667	No	No	No	No	8	0
334	5x66	6x30	alpha1a_on	0	5.4	No	No	No	No	5	0
335	6x51	7x34	alpha1a_on	0	4.28833	Yes	Yes	No	No	7	4
336	6x53	6x57	alpha1a_on	0	6.49667	No	No	No	No	6	5
337	7x49	7x53	alpha1a_on	0	3.685	No	Yes	No	Yes	9	9
338	E1x50	E1x51	alpha1a_on	0	3.055	Yes	Yes	No	Yes	8	3
339	E1x49	E1x50	alpha1a_on	0	4.98333	No	No	Yes	Yes	4	8
340	E1x50	E2.R202	alpha1a_on	0	3.165	Yes	Yes	No	No	8	0
341	2x43	8x50	alpha1a_on	0	2.84333	No	No	Yes	Yes	7	8
342	6x45	6x49	alpha1a_on	0	2.83833	No	No	No	No	5	7
343	6x28	6x32	alpha1a_on	0	2.81333	No	No	No	No	0	0
344	3x23	3x24	alpha1a_on	0	2.81	No	No	No	No	3	5
345	1x41	1x45	alpha1a_on	0	2.77	No	No	No	No	5	5
346	6x27	6x31	alpha1a_on	0	2.71167	No	No	No	No	0	0
347	2x39	2x40	alpha1a_on	0	2.64	No	No	No	Yes	8	8
348	1x48	1x52	alpha1a_on	0	2.63833	No	No	No	Yes	4	7
349	1x40	1x43	alpha1a_on	0	2.62167	No	No	No	Yes	3	5
350	7x31	E3.V418	alpha1a_on	0	2.61667	No	No	No	No	2	0
351	1x52	8x57	alpha1a_on	0	2.615	No	Yes	No	No	7	6
352	2x41	4x43	alpha1a_on	0	2.585	No	No	No	No	5	5
353	8x49	I1x49	alpha1a_on	0	2.57333	No	Yes	No	No	7	6
354	5x36	5x38	alpha1a_on	0	2.55667	Yes	Yes	No	No	6	5
355	2x59	E1x50	alpha1a_on	0	2.505	No	No	Yes	Yes	5	8
356	2x46	2x50	alpha1a_on	0	2.48833	No	Yes	Yes	No	9	9
357	2x54	2x57	alpha1a_on	0	2.435	No	No	Yes	No	7	8
358	6x28	6x29	alpha1a_on	0	2.41167	No	No	No	No	0	0
359	4x41	I2x53	alpha1a_on	0	2.40333	No	No	Yes	Yes	6	7
360	1x31	1x34	alpha1a_on	0	2.38	No	Yes	No	No	3	4
361	2x49	4x50	alpha1a_on	0	2.375	No	No	No	Yes	8	9
362	8x48	8x49	alpha1a_on	0	2.31	No	No	No	Yes	5	7
363	7x51	7x55	alpha1a_on	0	2.305	No	No	No	No	6	5
364	1x54	1x58	alpha1a_on	0	2.30167	No	No	No	No	7	2
365	1x48	1x49	alpha1a_on	0	2.26167	No	No	No	No	4	9
366	1x42	7x47	alpha1a_on	0	2.25167	No	No	No	No	7	6
367	2x46	3x39	alpha1a_on	0	2.25	No	Yes	No	No	9	9
368	5x58	6x41	alpha1a_on	0	2.21667	Yes	Yes	No	No	9	8
369	3x26	4x61	alpha1a_on	0	2.20833	No	No	No	No	6	5
370	1x53	8x54	alpha1a_on	0	2.18333	No	No	No	Yes	9	7
371	6x58	E3.S417	alpha1a_on	0	2.13333	No	No	No	No	4	0
372	5x37	5x38	alpha1a_on	0	2.12667	No	No	No	No	4	5
373	5x69	6x30	alpha1a_on	0	2.11667	No	No	No	No	5	0
374	7x30	E3.V418	alpha1a_on	0	2.06333	No	No	No	No	5	0
375	5x45	5x46	alpha1a_on	0	2.05833	No	No	No	No	4	5
376	4x52	4x55	alpha1a_on	0	2.04667	No	No	No	No	5	4
377	E1x50	E2.P201	alpha1a_on	0	2.02667	Yes	Yes	No	No	8	0
378	6x43	7x48	alpha1a_on	0	1.98667	No	No	No	No	7	6
379	5x63	5x67	alpha1a_on	0	1.98167	No	No	No	No	4	5
380	3x51	5x61	alpha1a_on	0	1.97667	No	Yes	No	No	8	9
381	5x48	5x49	alpha1a_on	0	1.965	No	Yes	No	No	6	5
382	2x38	4x39	alpha1a_on	0	1.94833	No	No	No	No	7	4
383	E2.D207	E2x51	alpha1a_on	0	1.94833	No	No	No	No	0	5
384	3x47	5x59	alpha1a_on	0	1.90833	No	No	No	No	9	3
385	E1x49	E2.E200	alpha1a_on	0	1.87	No	No	No	No	4	0
386	8x58	8x59	alpha1a_on	0	1.85167	No	No	No	No	7	5
387	2x42	3x45	alpha1a_on	0	1.84833	Yes	Yes	No	No	8	7
388	5x52	5x56	alpha1a_on	0	1.845	No	No	No	No	4	4
389	6x29	6x33	alpha1a_on	0	1.78167	No	No	No	No	0	0
390	6x41	6x42	alpha1a_on	0	1.76	No	No	No	No	8	5
391	5x62	6x37	alpha1a_on	0	1.75667	No	No	No	No	5	0
392	1x45	7x47	alpha1a_on	0	1.75	No	No	No	No	5	6
393	5x41	6x55	alpha1a_on	0	1.68167	No	No	Yes	Yes	6	7
394	1x39	1x40	alpha1a_on	0	1.625	No	No	No	No	7	3
395	2x66	E1x51	alpha1a_on	0	1.59667	No	Yes	No	Yes	5	3
396	I2x51	I2x52	alpha1a_on	0	1.595	No	No	No	No	7	5
397	4x60	5x36	alpha1a_on	0	1.58	Yes	No	Yes	Yes	7	6
398	8x53	I1x50	alpha1a_on	0	1.57667	No	No	No	Yes	7	8
399	5x61	5x64	alpha1a_on	0	1.55833	No	No	No	No	9	6
400	7x31	7x32	alpha1a_on	0	1.51	No	No	No	No	2	1
401	4x52	4x56	alpha1a_on	0	1.47	No	No	No	No	5	6
402	6x46	6x47	alpha1a_on	0	1.425	No	No	No	No	5	8
403	5x48	5x52	alpha1a_on	0	1.39667	No	Yes	No	No	6	4
404	E2x51	E2x52	alpha1a_on	0	1.36667	No	No	No	No	5	6
405	6x26	6x27	alpha1a_on	0	1.36333	No	Yes	No	No	0	0
406	2x45	2x48	alpha1a_on	0	1.35833	No	Yes	No	No	9	6
407	5x69	6x26	alpha1a_on	0	1.29333	No	No	No	Yes	5	0
408	3x21	E1x52	alpha1a_on	0	1.25833	No	No	No	Yes	8	5
409	1x35	7x35	alpha1a_on	0	1.175	No	No	No	No	5	5
410	1x52	8x58	alpha1a_on	0	1.15333	No	Yes	No	No	7	7
411	4x47	4x51	alpha1a_on	0	1.02667	No	No	No	No	4	4
412	3x25	3x26	alpha1a_on	0	1.01333	No	No	No	No	9	6
413	4x48	4x52	alpha1a_on	0	1.01333	No	No	No	No	2	5
414	6x26	I3.W377	alpha1a_on	0	1	No	Yes	No	No	0	0
415	1x31	1x35	alpha1a_on	0	0.993333	No	Yes	No	No	3	5
416	4x62	E2x51	alpha1a_on	0	0.97	No	No	No	No	4	5
417	8x56	8x57	alpha1a_on	0	0.968333	No	No	No	No	5	6
418	1x30	1x31	alpha1a_on	0	0.955	No	No	No	Yes	4	3
419	I2x52	I2x56	alpha1a_on	0	0.9	No	No	No	No	5	5
420	7x37	7x40	alpha1a_on	0	0.893333	No	Yes	No	No	5	7
421	1x29	1x30	alpha1a_on	0	0.886667	No	No	No	No	0	4
422	1x58	I1x51	alpha1a_on	0	0.826667	No	No	No	No	2	8
423	5x38	5x42	alpha1a_on	0	0.823333	No	No	No	No	5	5
424	I2x54	I2x57	alpha1a_on	0	0.805	No	No	No	Yes	6	6
425	1x32	NT.S44	alpha1a_on	0	0.8	No	No	No	No	4	0
426	1x46	1x47	alpha1a_on	0	0.793333	No	Yes	No	No	8	6
427	6x24	6x25	alpha1a_on	0	0.75	No	No	No	No	0	0
428	1x35	1x38	alpha1a_on	0	0.691667	No	No	No	No	5	5
429	1x58	1x59	alpha1a_on	0	0.648333	No	No	No	No	2	5
430	5x64	5x68	alpha1a_on	0	0.625	No	No	No	No	6	7
431	NT.L45	NT.Y43	alpha1a_on	0	0.586667	No	No	No	No	0	0
432	E3.C416	E3.V418	alpha1a_on	0	0.57	No	No	No	No	0	0
433	6x25	6x28	alpha1a_on	0	0.566667	No	No	No	No	0	0
434	I2x50	I2x51	alpha1a_on	0	0.54	No	No	No	No	8	7
435	1x43	1x44	alpha1a_on	0	0.47	No	Yes	No	No	5	4
436	2x62	E1x51	alpha1a_on	0	0.445	No	No	No	Yes	5	3
437	5x70	6x26	alpha1a_on	0	0.431667	No	No	No	Yes	5	0
438	2x66	NT.Y43	alpha1a_on	0	0.398333	No	Yes	No	No	5	0
439	6x24	I3.R376	alpha1a_on	0	0.355	No	No	No	No	0	0
440	1x36	1x37	alpha1a_on	0	0.285	No	No	No	No	6	5
441	3x30	4x57	alpha1a_on	0	0.285	No	No	No	Yes	6	8
442	1x31	NT	alpha1a_on	0	0.27	No	Yes	No	No	3	0
443	4x51	4x55	alpha1a_on	0	0.266667	No	No	No	No	4	4

Orange: nodes, hubs and links specific of alpha1a_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of alpha1a_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	alpha1a_off Avg Int. Strength	alpha1a_on Avg Int. Strength	alpha1a_off Num Of Links	alpha1a_on Num Of Links	ConSurf
1	1x56	alpha1a_off	3.145	3.465	4	1	8
2	2x50	alpha1a_off	6.61	7.52611	4	3	9
3	2x57	alpha1a_off	4.584	3.305	5	3	8
4	3x28	alpha1a_off	4.7525	4.55111	4	3	5
5	3x37	alpha1a_off	3.3875	3.17222	4	3	7
6	3x41	alpha1a_off	4.358	4.27667	5	1	6
7	4x53	alpha1a_off	2.9875	3.50167	4	3	8
8	4x60	alpha1a_off	4.885	1.58	4	1	7
9	4x64	alpha1a_off	3.865	0	4	0	6
10	5x39	alpha1a_off	3.8175	4.68	4	3	8
11	Lig	Shared	6.34357	9.09933	14	10	0
12	2x42	Shared	3.628	4.687	5	5	8
13	E1x50	Shared	5.084	4.32445	5	9	8
14	I2x53	Shared	5.775	8.24375	4	4	7
15	5x36	Shared	6.3875	3.95542	4	4	6
16	5x47	Shared	5.438	7.27067	5	5	8
17	5x58	Shared	5.592	4.264	5	5	9
18	6x44	Shared	5.096	4.43583	5	4	9
19	6x48	Shared	4.866	7.14556	5	6	8
20	6x51	Shared	4.924	6.482	5	5	7
21	6x52	Shared	4.99	6.33111	6	6	7
22	6x55	Shared	3.57	4.667	5	5	7
23	7x42	Shared	7.385	5.86444	4	6	7
24	8x50	Shared	4.2575	8.62375	4	4	8
25	1x31	alpha1a_on	0	1.14958	0	4	3
26	1x43	alpha1a_on	2.91	2.635	2	4	5
27	1x46	alpha1a_on	1.72333	3.34792	3	4	8
28	1x50	alpha1a_on	4.44	6.65333	3	5	9
29	1x52	alpha1a_on	4.87	4.29167	1	4	7
30	I1x50	alpha1a_on	4.54	5.932	2	5	8
31	2x40	alpha1a_on	6.97	3.19875	1	4	8
32	2x45	alpha1a_on	4.885	5.17167	2	4	9
33	2x46	alpha1a_on	2.44333	3.62208	3	4	9
34	2x56	alpha1a_on	3.28	4.76167	3	4	8
35	2x66	alpha1a_on	2.01667	1.23375	3	4	5
36	E1x51	alpha1a_on	2.67	2.17625	1	4	3
37	E1x52	alpha1a_on	7.02	4.85	1	4	5
38	3x42	alpha1a_on	1.735	6.339	2	5	7
39	3x49	alpha1a_on	4.13	5.83833	3	4	9
40	3x51	alpha1a_on	8.605	5.59567	2	5	8
41	I2x57	alpha1a_on	4.48	6.61333	3	6	6
42	4x50	alpha1a_on	5.42	5.32167	2	4	9
43	4x57	alpha1a_on	5.16667	3.79	3	4	8
44	5x48	alpha1a_on	3.165	3.236	2	5	6
45	6x26	alpha1a_on	0	1.02208	0	4	0
46	7x37	alpha1a_on	2.11	5.50833	2	4	5
47	7x49	alpha1a_on	4.96	5.0325	2	4	9
48	7x53	alpha1a_on	3.36667	4.53583	3	6	9
49	8x49	alpha1a_on	2.65	3.07917	1	4	7
50	8x54	alpha1a_on	6.23333	6.10208	3	4	7

Orange: nodes, hubs and links specific of alpha1a_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of alpha1a_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	alpha1a_off Recurrence	alpha1a_on Recurrence	alpha1a_off Hub1?	alpha1a_on Hub1?	alpha1a_off Hub2?	alpha1a_on Hub2?	ConSurf1	ConSurf2
1	2x60	Lig	alpha1a_off	20.8116	0	No	No	Yes	Yes	7	0
2	7x38	Lig	alpha1a_off	10.6295	0.876532	No	No	Yes	Yes	6	0
3	2x57	2x60	alpha1a_off	18.5264	0	Yes	No	No	No	8	7
4	2x57	7x42	alpha1a_off	18.8435	0	Yes	No	Yes	Yes	8	7
5	1x43	2x57	alpha1a_off	26.8705	9.62995	No	Yes	Yes	No	5	8
6	1x50	7x50	alpha1a_off	56.7176	1.40007	No	Yes	No	No	9	9
7	2x50	3x39	alpha1a_off	75.4066	0	Yes	No	No	No	9	9
8	3x39	7x45	alpha1a_off	79.7088	0	No	No	No	No	9	9
9	6x48	6x51	alpha1a_off	70.0878	0	Yes	Yes	Yes	Yes	8	7
10	6x51	Lig	alpha1a_off	66.1191	9.24126	Yes	Yes	Yes	Yes	7	0
11	6x48	6x52	alpha1a_off	68.9086	9.8243	Yes	Yes	Yes	Yes	8	7
12	1x47	1x51	alpha1a_off	16.1679	0	No	No	No	No	6	4
13	1x43	1x47	alpha1a_off	21.5273	0	No	Yes	No	No	5	6
14	1x56	8x50	alpha1a_off	29.6601	0	Yes	No	Yes	Yes	8	8
15	7x53	8x50	alpha1a_off	39.0127	0	No	Yes	Yes	Yes	9	8
16	1x53	7x53	alpha1a_off	43.3312	0	No	No	No	Yes	9	9
17	1x53	7x50	alpha1a_off	52.326	0	No	No	No	No	9	9
18	1x60	8x53	alpha1a_off	12.6383	0	No	No	No	No	6	7
19	1x56	8x53	alpha1a_off	15.1187	0	Yes	No	No	No	8	7
20	2x46	3x46	alpha1a_off	50.9515	0	No	Yes	No	No	9	9
21	2x46	3x43	alpha1a_off	60.8979	0	No	Yes	No	No	9	8
22	6x44	6x48	alpha1a_off	97.5114	0	Yes	Yes	Yes	Yes	9	8
23	5x461	Lig	alpha1a_off	22.8855	0	No	No	Yes	Yes	6	0
24	3x37	5x461	alpha1a_off	21.1288	1.36041	Yes	No	No	No	7	6
25	3x28	Lig	alpha1a_off	33.0514	0	Yes	No	Yes	Yes	5	0
26	3x28	E1x50	alpha1a_off	13.2238	0	Yes	No	Yes	Yes	5	8
27	3x37	3x41	alpha1a_off	10.2879	0	Yes	No	Yes	No	7	6
28	3x40	6x44	alpha1a_off	17.339	0	No	No	Yes	Yes	8	9
29	3x41	5x50	alpha1a_off	12.7846	0	Yes	No	No	No	6	9
30	3x44	5x50	alpha1a_off	15.7856	2.74858	No	No	No	No	6	9
31	3x44	5x53	alpha1a_off	14.0777	1.37627	No	No	No	No	6	6
32	6x44	6x45	alpha1a_off	48.0644	0	Yes	Yes	No	No	9	5
33	6x41	6x45	alpha1a_off	45.5351	0	No	No	No	No	8	5
34	6x41	I3.V234	alpha1a_off	43.0709	0	No	No	No	No	8	2
35	5x58	I3.V234	alpha1a_off	44.3234	0	Yes	Yes	No	No	9	2
36	5x53	5x57	alpha1a_off	10.6132	0	No	No	No	No	6	6
37	5x58	5x61	alpha1a_off	29.8715	0	Yes	Yes	No	No	9	9
38	I2x53	I2x57	alpha1a_off	15.444	3.05398	Yes	Yes	No	Yes	7	6
39	4x57	4x58	alpha1a_off	73.8939	2.71685	No	Yes	No	No	8	4
40	4x58	4x61	alpha1a_off	71.4623	0	No	No	No	No	4	5
41	4x61	5x39	alpha1a_off	66.8835	0	No	No	Yes	No	5	8
42	4x64	5x39	alpha1a_off	26.8461	0	Yes	No	Yes	No	6	8
43	4x64	5x36	alpha1a_off	21.8852	0	Yes	No	Yes	Yes	6	6
44	5x39	E2.N179	alpha1a_off	29.6031	0	Yes	No	No	No	8	5
45	5x36	E2.N179	alpha1a_off	21.5436	0	Yes	Yes	No	No	6	5
46	5x36	5x37	alpha1a_off	38.0774	0	Yes	Yes	No	No	6	4
47	5x37	6x60	alpha1a_off	32.6854	2.70892	No	No	No	No	4	5
48	3x54	5x61	alpha1a_off	26.9112	2.31627	No	No	No	No	8	9
49	3x54	I3.L227	alpha1a_off	21.2752	0	No	No	No	No	8	3
50	5x71	I3.L227	alpha1a_off	18.6727	0	No	No	No	No	4	3
51	5x71	I3.D224	alpha1a_off	12.5163	0	No	No	No	No	4	3
52	3x43	6x40	alpha1a_off	21.1858	0	No	No	No	No	8	8
53	6x40	7x52	alpha1a_off	18.1278	0	No	No	No	No	8	8
54	6x39	7x52	alpha1a_off	12.4268	8.23781	No	No	No	No	7	8
55	6x60	6x61	alpha1a_off	21.8526	1.35644	No	No	No	No	5	4
56	6x61	E3.P299	alpha1a_off	16.4118	0	No	No	No	No	4	2
57	E3.D300	E3.P299	alpha1a_off	10.9548	0	No	No	No	No	1	2
58	3x40	5x50	alpha1a_off	14.5738	4.11296	No	No	No	No	8	9
59	1x50	2x50	Shared	71.5761	35.1208	No	Yes	Yes	No	9	9
60	6x48	7x45	Shared	83.6776	94.2133	Yes	Yes	No	No	8	9
61	6x52	Lig	Shared	100	11.9105	Yes	Yes	Yes	Yes	7	0
62	2x39	3x49	Shared	15.0049	32.7172	No	No	No	Yes	8	9
63	2x42	3x49	Shared	41.4037	47.5786	Yes	Yes	No	Yes	8	9
64	2x42	3x46	Shared	50.0813	52.4848	Yes	Yes	No	No	8	9
65	3x43	6x44	Shared	79.8796	21.4493	No	No	Yes	Yes	8	9
66	5x47	6x44	Shared	40.7043	20.422	Yes	Yes	Yes	Yes	8	9
67	5x47	6x52	Shared	42.2658	15.2858	Yes	Yes	Yes	Yes	8	7
68	2x53	2x56	Shared	21.2996	13.5605	No	No	No	Yes	8	8
69	2x56	3x28	Shared	12.9392	58.3588	No	Yes	Yes	No	8	5
70	2x56	3x32	Shared	13.4353	34.9542	No	Yes	No	No	8	7
71	3x32	Lig	Shared	15.2814	35.7197	No	No	Yes	Yes	7	0
72	2x53	3x35	Shared	10.6783	11.3196	No	No	No	No	8	6
73	3x33	Lig	Shared	83.2954	13.3542	No	No	Yes	Yes	6	0
74	3x33	4x57	Shared	81.0914	12.204	No	No	No	Yes	6	8
75	3x49	I2x53	Shared	24.0973	11.7162	No	Yes	Yes	Yes	9	7
76	1x46	1x50	Shared	15.1187	22.7859	No	Yes	No	Yes	8	9
77	7x42	Lig	Shared	28.5296	47.2693	Yes	Yes	Yes	Yes	7	0
78	2x54	2x57	alpha1a_on	0	12.3468	No	No	Yes	No	7	8
79	1x46	2x54	alpha1a_on	0	13.6795	No	Yes	No	No	8	7
80	2x46	2x50	alpha1a_on	0	37.4926	No	Yes	Yes	No	9	9
81	2x46	7x49	alpha1a_on	0	53.3574	No	Yes	No	Yes	9	9
82	7x49	7x53	alpha1a_on	0	100	No	Yes	No	Yes	9	9
83	3x46	7x53	alpha1a_on	0	48.1339	No	No	No	Yes	9	9
84	2x39	2x40	alpha1a_on	0	34.8511	No	No	No	Yes	8	8
85	2x40	I1x50	alpha1a_on	0	30.1551	No	Yes	No	Yes	8	8
86	8x50	I1x50	alpha1a_on	0	19.2758	Yes	Yes	No	Yes	8	8
87	7x54	8x50	alpha1a_on	0	15.7181	No	No	Yes	Yes	7	8
88	7x54	8x54	alpha1a_on	2.55368	14.4053	No	No	No	Yes	7	7
89	1x52	8x54	alpha1a_on	2.55368	10.6691	No	Yes	No	Yes	7	7
90	2x46	3x42	alpha1a_on	9.36077	19.4225	No	Yes	No	Yes	9	7
91	7x45	7x49	alpha1a_on	0	94.6298	No	No	No	Yes	9	9
92	6x48	Lig	alpha1a_on	0	83.2348	Yes	Yes	Yes	Yes	8	0
93	2x56	7x42	alpha1a_on	0	37.4926	No	Yes	Yes	Yes	8	7
94	2x59	3x28	alpha1a_on	0	54.4759	No	No	Yes	No	5	5
95	2x59	E1x50	alpha1a_on	0	52.3857	No	No	Yes	Yes	5	8
96	7x39	7x42	alpha1a_on	7.74235	12.5213	No	No	Yes	Yes	6	7
97	7x35	7x39	alpha1a_on	0	11.3315	No	No	No	No	5	6
98	E1x50	E1x52	alpha1a_on	2.82206	11.1411	Yes	Yes	No	Yes	8	5
99	E1x50	E1x51	alpha1a_on	0	18.895	Yes	Yes	No	Yes	8	3
100	3x38	4x53	alpha1a_on	7.44144	10.2526	No	No	Yes	No	8	8
101	3x37	4x53	alpha1a_on	8.10019	10.6889	Yes	No	Yes	No	7	8
102	3x50	7x53	alpha1a_on	0	32.9989	No	No	No	Yes	9	9
103	6x40	7x53	alpha1a_on	0	33.1972	No	No	No	Yes	8	9
104	5x58	6x40	alpha1a_on	0	32.3801	Yes	Yes	No	No	9	8
105	3x47	5x58	alpha1a_on	6.2866	26.3079	No	No	Yes	Yes	9	9
106	3x50	5x58	alpha1a_on	0	37.1356	No	No	Yes	Yes	9	9
107	3x47	5x57	alpha1a_on	0	22.8017	No	No	No	No	9	6
108	3x51	5x57	alpha1a_on	8.85654	21.128	No	Yes	No	No	8	6
109	5x43	Lig	alpha1a_on	2.62687	13.0131	No	No	Yes	Yes	7	0
110	5x39	5x43	alpha1a_on	0	11.9542	Yes	No	No	No	8	7
111	5x58	6x37	alpha1a_on	0	39.198	Yes	Yes	No	No	9	0
112	5x62	6x37	alpha1a_on	0	37.2863	No	No	No	No	5	0
113	5x62	5x66	alpha1a_on	0	33.4193	No	No	No	No	5	5
114	5x66	6x30	alpha1a_on	0	31.2894	No	No	No	No	5	0
115	6x30	6x33	alpha1a_on	0	16.9317	No	No	No	No	0	0
116	7x52	7x53	alpha1a_on	0	12.3468	No	No	No	Yes	8	9
117	5x47	6x49	alpha1a_on	4.15582	14.8297	Yes	Yes	No	No	8	7
118	6x49	6x53	alpha1a_on	0	12.204	No	No	No	No	7	6
119	6x51	6x52	alpha1a_on	0.382238	11.7479	Yes	Yes	Yes	Yes	7	7
120	6x51	7x34	alpha1a_on	0	19.2321	Yes	Yes	No	No	7	4
121	6x54	7x34	alpha1a_on	0	16.8366	No	No	No	No	5	4
122	6x54	7x37	alpha1a_on	6.56311	14.0523	No	No	No	Yes	5	5
123	6x53	6x57	alpha1a_on	0	10.8793	No	No	No	No	6	5
124	6x29	6x33	alpha1a_on	0	12.5689	No	No	No	No	0	0
125	6x28	6x29	alpha1a_on	0	10.3756	No	No	No	No	0	0
126	5x69	6x30	alpha1a_on	0	12.91	No	No	No	No	5	0
127	5x69	6x26	alpha1a_on	0	10.7246	No	No	No	Yes	5	0
128	2x66	E1x51	alpha1a_on	0	14.6155	No	Yes	No	Yes	5	3
129	3x43	7x53	alpha1a_on	0	17.7726	No	No	No	Yes	8	9

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
2x60	Lig	alpha1a_off	2.79	0	0	0	1	0
2x63	Lig	alpha1a_off	10.17	0	0	0	1	0
2x64	Lig	alpha1a_off	3.69	0	0	0	1	0
3x28	Lig	alpha1a_off	7.39	0	1	0	1	0
3x32	Lig	Shared	8.81	14.3567	1	1	1	0
3x33	Lig	Shared	4.14	14.8233	0	0	1	0
3x36	Lig	Shared	5.89	8.60667	0	1	1	0
5x43	Lig	Shared	4.18	4.64167	0	0	1	0
5x461	Lig	alpha1a_off	2.79	0	0	0	1	0
6x51	Lig	Shared	9.04	10.4083	1	1	1	0
6x52	Lig	Shared	4.52	3.33167	1	1	1	0
6x55	Lig	Shared	5.24	5.60667	1	1	1	0
7x38	Lig	Shared	15.81	15.99	0	1	1	0
7x42	Lig	Shared	4.35	9.225	1	1	1	0
2x56	3x28	Shared	2.45	3.15667	0	1	2	1
2x56	3x32	Shared	2.92	7.78833	0	1	2	1
2x57	2x60	alpha1a_off	3	0	1	5	2	1
2x57	7x39	alpha1a_off	2.28	0	1	5	2	2
2x57	7x42	alpha1a_off	11.72	0	1	5	2	1
2x64	7x35	Shared	9.45	7.2	0	0	1	2
3x28	E1x50	alpha1a_off	6.56	0	1	0	1	2
E1x50	E2x50	Shared	5.22	7.18333	1	2	2	2
3x28	E2x50	alpha1a_off	2.61	0	1	0	1	2
3x32	7x42	Shared	5.75	5.75	1	1	1	1
3x33	4x57	Shared	4.85	5.385	0	0	1	2
3x37	5x461	Shared	6.4	4.79667	4	0	2	1
3x40	6x44	alpha1a_off	7.54	0	0	0	2	2
5x40	6x55	Shared	3.04	3.995	0	0	2	1
5x44	6x52	Shared	2.77	3.025	0	0	2	1
5x47	5x48	Shared	5.16	5.36	0	1	2	2
5x47	6x44	Shared	3.22	3.75167	0	1	2	2
5x47	6x52	Shared	13.93	16.7767	0	1	2	1
6x44	6x48	alpha1a_off	6.01	0	0	1	2	1
6x48	6x51	alpha1a_off	6.01	0	1	1	1	1
6x48	6x52	Shared	3.01	7.35	1	1	1	1
6x48	7x41	Shared	7.04	7.97333	1	1	1	2
6x48	7x45	Shared	2.26	9.605	1	1	1	2
6x51	6x52	Shared	3.22	3.395	1	1	1	1
6x51	6x55	Shared	3.73	8.425	1	1	1	1
6x51	7x37	alpha1a_off	2.62	0	1	1	1	2
6x52	6x55	alpha1a_off	2.49	0	1	1	1	1
6x55	6x56	alpha1a_off	3.35	0	1	1	1	2
7x34	7x38	alpha1a_off	5.36	0	0	0	2	1
7x35	7x38	alpha1a_off	2.48	0	0	0	2	1
7x39	7x42	Shared	7.72	3.215	1	0	2	1
2x56	7x42	alpha1a_on	0	4.62667	0	1	2	1
2x59	3x28	alpha1a_on	0	7.565	0	0	2	1
2x63	E1x50	alpha1a_on	0	3.01333	0	0	1	2
3x28	3x29	alpha1a_on	0	2.93167	1	0	1	2
3x36	6x48	alpha1a_on	0	4.35167	0	1	1	1
3x40	6x48	alpha1a_on	0	9.59	0	0	2	1
6x55	E2x52	alpha1a_on	0	3.62667	1	1	1	2
5x48	6x52	alpha1a_on	0	4.10833	0	1	2	1
6x48	Lig	alpha1a_on	0	4.00333	1	1	1	0
6x51	7x38	alpha1a_on	0	5.89333	1	1	1	1
7x35	7x39	alpha1a_on	0	3.67333	0	0	2	2
7x38	7x42	alpha1a_on	0	8.76667	0	1	1	1
2x60	7x42	alpha1a_on	0	3.60333	0	0	1	1
5x39	5x43	alpha1a_on	0	4.66333	2	6	2	1
5x44	6x56	alpha1a_on	0	3.38	0	0	2	2
6x51	7x34	alpha1a_on	0	4.28833	1	1	1	2
2x59	E1x50	alpha1a_on	0	2.505	0	0	2	2
5x41	6x55	alpha1a_on	0	1.68167	0	0	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	alpha1a_off	7YMJ-Alpha1A-Tamsulosin
	alpha1a_on	7EJ0-α_2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α_2a-Brimonidine-Go/β1/γ2 7EJA-α_2a-Dexmedetomidine-Go/β1/γ2 7EJK-α_2a-Oxymetazoline-Go/β1/γ2 7W6P-α_2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α_2a-PubChem 164946676-Go/β1/γ2

Network Difference
Value	alpha1a_off	alpha1a_on
I_min	2.26	2.85667
Number of Linked Nodes	241	269
Number of Specific Nodes	34 (14.11%)	62 (23.05%)
Number of Shared Nodes	207 (85.89%)	207 (76.95%)
Number of Links	245	293
Number of Specific Links	150 (61.22%)	198 (67.58%)
Number of Shared Links	95 (38.78%)	95 (32.42%)
Number of Hubs	24	40
Number of Specific Hubs	10 (41.67%)	26 (65.00%)
Number of Shared Hubs	14 (58.33%)	14 (35.00%)
Average % Shared Neighbours (Jaccard)	19.16
Average % Shared Neighbours (Otsuka)	25.52
Average % Shared Neighbours (Overlap Coefficient)	31.83
Average % Shared Cliques (k3-6)	53.23
Graphlets Similarity	0.560745

Paths Difference
Value	alpha1a_off	alpha1a_on
Number Of Nodes in MetaPath	72	70
Specific Nodes in MetaPath	37 (51.39%)	35 (50.00%)
Shared Nodes in MetaPath	207 (85.89%)	207 (85.89%)
Number Of Links MetaPath	77	71
Specific Links in MetaPath	58 (75.32%)	52 (73.24%)
Shared Links in MetaPath	95 (38.78%)	95 (38.78%)
Number of Shortest Paths	34387	55216
Length Of Smallest Path	3	3
Average Path Length	12.7507	13.2317
Length of Longest Path	30	27
Minimum Path Strength	1.365	0.557222
Average Path Strength	4.66953	4.93504
Maximum Path Strength	12.99	15.4067
Minimum Path Correlation	0.7	0.703333
Average Path Correlation	0.916221	0.916718
Maximum Path Correlation	0.99	0.99
Minimum % Of Corr. Nodes	5	4
Average % Of Corr. Nodes	48.5203	42.0614
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	38.439	47.0318
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

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