psnGPCR

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Orange: nodes, hubs and links specific of alpha2_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of alpha2_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	alpha2_off Int. Strength	alpha2_on Int. Strength	alpha2_off Hub1?	alpha2_on Hub1?	alpha2_off Hub2?	alpha2_on Hub2?	ConSurf1	ConSurf2
1	E2x52	Lig	alpha2_off	6.7	0	No	No	Yes	Yes	7	0
2	NT	NT	alpha2_off	5.33	0	Yes	No	Yes	No	4	4
3	E2	NT	alpha2_off	19.47	0	Yes	No	Yes	No	5	4
4	E1x49	NT	alpha2_off	8.34	0	No	No	Yes	No	4	4
5	2x64	NT	alpha2_off	11.37	0	No	No	Yes	No	6	4
6	2x65	NT	alpha2_off	8.21	0	No	No	Yes	No	7	4
7	1x42	2x57	alpha2_off	7.07	0	No	No	Yes	No	7	8
8	1x43	2x58	alpha2_off	5.08	0	No	No	No	No	8	9
9	1x53	7x53	alpha2_off	5.05	0	No	No	Yes	Yes	9	9
10	1x60	8x53	alpha2_off	4.89	0	No	No	No	No	7	8
11	2x39	3x49	alpha2_off	5.22	0	No	No	Yes	No	8	9
12	2x40	2x43	alpha2_off	5.49	0	No	No	No	No	9	8
13	2x43	7x53	alpha2_off	7.03	0	No	No	Yes	Yes	8	9
14	2x45	4x50	alpha2_off	6.18	0	No	No	Yes	No	9	9
15	2x46	3x42	alpha2_off	6.43	0	No	No	Yes	Yes	9	8
16	2x57	7x39	alpha2_off	5.82	0	Yes	No	Yes	No	8	8
17	2x57	7x42	alpha2_off	8.38	0	Yes	No	Yes	Yes	8	8
18	2x59	3x24	alpha2_off	20.04	0	No	No	Yes	No	7	5
19	2x61	2x65	alpha2_off	8.3	0	No	No	No	No	8	7
20	E1x49	E2	alpha2_off	20.12	0	No	No	Yes	No	4	5
21	E1x50	E1x52	alpha2_off	17.04	0	Yes	Yes	No	No	9	7
22	3x23	3x24	alpha2_off	7.5	0	No	No	Yes	No	5	5
23	3x23	3x27	alpha2_off	6.13	0	No	No	No	No	5	6
24	3x24	3x27	alpha2_off	7.36	0	Yes	No	No	No	5	6
25	3x28	3x29	alpha2_off	4.69	0	Yes	Yes	No	No	5	7
26	3x33	4x57	alpha2_off	4.85	0	No	No	No	No	8	8
27	3x36	6x48	alpha2_off	9.14	0	No	No	Yes	Yes	8	8
28	3x37	4x57	alpha2_off	6.4	0	No	No	No	No	8	8
29	3x39	6x44	alpha2_off	6.18	0	No	No	Yes	Yes	9	9
30	3x41	4x52	alpha2_off	4.61	0	No	No	No	No	8	6
31	3x41	4x53	alpha2_off	4.85	0	No	No	No	No	8	8
32	3x43	5x54	alpha2_off	7.07	0	No	No	No	Yes	9	9
33	3x43	6x41	alpha2_off	9.9	0	No	No	No	No	9	8
34	3x43	6x44	alpha2_off	7.97	0	No	No	Yes	Yes	9	9
35	3x44	5x53	alpha2_off	4.91	0	No	No	No	No	8	7
36	3x46	6x37	alpha2_off	5.71	0	No	No	No	No	9	8
37	3x50	6x30	alpha2_off	5.82	0	Yes	No	No	No	9	8
38	3x50	6x33	alpha2_off	6.41	0	Yes	No	No	No	9	8
39	3x50	6x34	alpha2_off	12.94	0	Yes	No	No	No	9	8
40	3x50	6x37	alpha2_off	6.07	0	Yes	No	No	No	9	8
41	I2x54	I2x57	alpha2_off	6.03	0	No	No	Yes	Yes	7	8
42	4x41	I2x56	alpha2_off	11.14	0	No	No	No	No	7	5
43	4x38	4x41	alpha2_off	5.17	0	No	No	No	No	8	7
44	4x58	4x60	alpha2_off	18.78	0	No	No	No	No	6	8
45	E2	E2	alpha2_off	4.76	0	Yes	No	Yes	No	5	5
46	5x39	E2x52	alpha2_off	5.86	0	Yes	Yes	No	No	7	7
47	5x36	E2	alpha2_off	10.52	0	No	No	Yes	No	6	5
48	6x58	E2	alpha2_off	6.9	0	No	No	Yes	No	4	5
49	5x37	6x62	alpha2_off	6.47	0	No	No	No	No	5	5
50	5x51	6x45	alpha2_off	5.12	0	No	No	No	No	7	8
51	5x58	5x61	alpha2_off	10.88	0	Yes	Yes	No	No	9	9
52	5x58	5x62	alpha2_off	5.96	0	Yes	Yes	No	Yes	9	6
53	5x58	6x38	alpha2_off	5.34	0	Yes	Yes	No	No	9	8
54	5x67	5x68	alpha2_off	8.5	0	No	No	No	No	5	8
55	6x29	8x49	alpha2_off	8.34	0	No	No	Yes	No	7	8
56	6x33	6x37	alpha2_off	7.31	0	No	No	No	No	8	8
57	6x33	8x47	alpha2_off	6.04	0	No	No	No	No	8	9
58	6x39	7x52	alpha2_off	4.61	0	No	No	No	No	8	9
59	6x40	7x49	alpha2_off	8.87	0	No	No	No	No	9	9
60	6x40	7x52	alpha2_off	4.61	0	No	No	No	No	9	9
61	6x44	7x45	alpha2_off	11.3	0	Yes	Yes	No	No	9	9
62	6x51	6x52	alpha2_off	12.86	0	Yes	Yes	Yes	No	8	8
63	6x51	6x55	alpha2_off	12.38	0	Yes	Yes	Yes	No	8	8
64	6x54	E3	alpha2_off	9.7	0	No	No	Yes	No	6	4
65	6x57	E3	alpha2_off	4.76	0	No	No	Yes	No	6	4
66	6x58	6x62	alpha2_off	11.32	0	No	No	No	No	4	5
67	6x58	E3	alpha2_off	9.02	0	No	No	Yes	No	4	4
68	7x35	7x38	alpha2_off	4.96	0	No	No	Yes	No	5	6
69	7x38	7x39	alpha2_off	5.01	0	Yes	No	Yes	No	6	8
70	7x49	7x53	alpha2_off	5.81	0	No	No	Yes	Yes	9	9
71	7x53	8x50	alpha2_off	18.57	0	Yes	Yes	Yes	Yes	9	9
72	8x48	8x49	alpha2_off	9.14	0	No	No	Yes	No	5	8
73	8x48	8x52	alpha2_off	5.84	0	No	No	No	No	5	5
74	8x50	8x54	alpha2_off	7.5	0	Yes	Yes	No	No	9	8
75	8x56	CT	alpha2_off	6.77	0	No	No	No	No	6	5
76	8x58	8x59	alpha2_off	7.31	0	No	No	No	No	8	4
77	6x35	7x56	alpha2_off	4.29	0	No	No	No	No	7	8
78	5x41	6x60	alpha2_off	4.28	0	No	No	No	No	7	5
79	1x52	8x58	alpha2_off	4.15	0	No	No	No	No	8	8
80	I1x48	I1x49	alpha2_off	4.15	0	No	No	No	No	8	7
81	7x31	7x32	alpha2_off	4.06	0	No	No	No	No	2	3
82	3x35	4x50	alpha2_off	4.01	0	No	Yes	Yes	No	7	9
83	3x30	4x59	alpha2_off	3.74	0	No	No	No	No	8	9
84	8x51	8x55	alpha2_off	3.71	0	No	No	No	No	9	5
85	4x57	4x59	alpha2_off	3.56	0	No	No	No	No	8	9
86	1x35	NT	alpha2_off	3.52	0	No	No	Yes	No	5	4
87	3x34	4x50	alpha2_off	3.42	0	No	No	Yes	No	8	9
88	6x47	7x40	alpha2_off	3.27	0	No	No	No	No	9	8
89	1x54	2x44	alpha2_off	3.21	0	No	No	No	No	7	8
90	1x46	7x46	alpha2_off	3.2	0	No	No	No	No	8	9
91	6x29	6x32	alpha2_off	3.2	0	No	No	No	No	7	8
92	1x42	7x43	alpha2_off	3.17	0	No	No	No	No	7	6
93	4x56	5x461	alpha2_off	3.1	0	No	No	No	No	8	8
94	1x51	1x55	alpha2_off	3.07	0	No	No	No	No	6	6
95	1x51	2x51	alpha2_off	3.07	0	No	No	No	No	6	8
96	3x47	6x41	alpha2_off	3.07	0	No	No	No	No	9	8
97	5x57	5x61	alpha2_off	3.07	0	No	No	No	No	8	9
98	7x47	7x48	alpha2_off	3	0	No	No	No	No	8	7
99	1x32	2x65	alpha2_off	2.98	0	No	No	No	No	5	7
100	1x57	2x43	alpha2_off	2.98	0	No	No	No	No	9	8
101	4x47	4x51	alpha2_off	2.98	0	No	No	No	No	6	5
102	4x62	E2x52	alpha2_off	2.98	0	No	No	No	No	5	7
103	I2x51	I2x52	alpha2_off	2.85	0	No	No	No	No	7	6
104	3x55	3x56	alpha2_off	2.83	0	No	No	No	No	8	7
105	3x21	E1x50	alpha2_off	2.81	0	No	No	Yes	Yes	8	9
106	2x52	2x551	alpha2_off	2.77	0	No	No	No	No	8	6
107	2x551	3x31	alpha2_off	2.77	0	No	No	No	No	6	6
108	2x62	E1x52	alpha2_off	2.77	0	No	No	No	No	7	7
109	1x31	NT	alpha2_off	2.67	0	No	No	Yes	No	5	4
110	5x64	5x68	alpha2_off	2.62	0	No	No	No	No	7	8
111	1x41	1x45	alpha2_off	2.14	0	No	No	No	No	4	5
112	2x67	NT	alpha2_off	1.95	0	No	No	Yes	No	6	4
113	1x33	1x34	alpha2_off	1.95	0	No	No	No	No	6	4
114	1x34	1x37	alpha2_off	1.95	0	No	No	No	No	4	5
115	7x30	7x32	alpha2_off	1.95	0	No	No	No	No	7	3
116	2x37	2x38	alpha2_off	1.87	0	No	No	No	No	8	7
117	4x56	5x46	alpha2_off	1.76	0	No	No	No	No	8	6
118	5x54	5x55	alpha2_off	1.75	0	No	Yes	No	No	9	6
119	1x28	1x31	alpha2_off	1.71	0	No	No	No	No	6	5
120	3x29	E2x51	alpha2_off	1.71	0	No	No	No	No	7	3
121	1x47	2x54	alpha2_off	1.7	0	No	No	No	No	7	8
122	4x39	4x43	alpha2_off	1.67	0	No	No	No	No	6	5
123	2x62	2x66	alpha2_off	1.61	0	No	No	No	No	7	6
124	5x65	6x31	alpha2_off	1.61	0	No	No	No	No	8	7
125	1x38	1x39	alpha2_off	1.6	0	No	No	No	No	6	7
126	1x44	1x48	alpha2_off	1.6	0	No	No	No	No	5	6
127	1x59	8x53	alpha2_off	1.6	0	No	No	No	No	7	8
128	3x55	5x64	alpha2_off	1.59	0	No	No	No	No	8	7
129	3x34	4x54	alpha2_off	1.58	0	No	No	No	No	8	7
130	6x28	6x32	alpha2_off	1.38	0	No	No	No	No	6	8
131	5x62	5x65	alpha2_off	1.33	0	No	Yes	No	No	6	8
132	5x38	5x42	alpha2_off	1.24	0	No	No	No	No	5	7
133	3x32	Lig	Shared	29.1	9.97	No	No	Yes	Yes	9	0
134	3x33	Lig	Shared	11.34	3.65	No	No	Yes	Yes	8	0
135	3x36	Lig	Shared	6.59	9.07	No	No	Yes	Yes	8	0
136	6x51	Lig	Shared	12.64	11.93	Yes	Yes	Yes	Yes	8	0
137	6x52	Lig	Shared	7.58	3.98	Yes	No	Yes	Yes	8	0
138	6x55	Lig	Shared	8.11	10.52	Yes	No	Yes	Yes	8	0
139	7x38	Lig	Shared	16.85	14.91	Yes	No	Yes	Yes	6	0
140	7x42	Lig	Shared	5.68	5.74	Yes	Yes	Yes	Yes	8	0
141	1x39	2x61	Shared	10.43	2.85	No	No	No	No	7	8
142	1x39	7x39	Shared	4.9	7.05	No	No	Yes	No	7	8
143	1x45	7x47	Shared	5.28	6.61	No	No	No	No	5	8
144	1x46	7x47	Shared	4.8	3.2	No	No	No	No	8	8
145	1x50	2x47	Shared	4.69	4.69	No	Yes	No	No	9	9
146	1x50	2x50	Shared	12.12	12.12	No	Yes	No	Yes	9	9
147	1x50	7x50	Shared	11.4	11.4	No	Yes	No	No	9	9
148	1x57	2x44	Shared	4.81	4.81	No	No	No	No	9	8
149	1x60	I1x50	Shared	9.01	7.51	No	No	No	No	7	9
150	8x49	I1x49	Shared	6.18	10.31	Yes	No	No	No	8	7
151	8x50	I1x50	Shared	12.18	12.18	Yes	Yes	No	No	9	9
152	2x37	2x39	Shared	4.55	4.55	No	No	No	No	8	8
153	2x38	4x39	Shared	7.79	7.79	No	No	No	No	7	6
154	2x39	I2x57	Shared	24.53	11.68	No	No	Yes	Yes	8	8
155	2x42	3x46	Shared	5.02	3.77	Yes	Yes	No	No	8	9
156	2x42	3x49	Shared	4.78	4.78	Yes	Yes	Yes	No	8	9
157	2x42	4x42	Shared	6.55	6.28	Yes	Yes	No	No	8	8
158	2x42	4x45	Shared	5.19	6.28	Yes	Yes	No	No	8	7
159	2x45	3x42	Shared	8.37	6.97	No	No	Yes	Yes	9	8
160	2x45	4x46	Shared	7.74	7.74	No	No	No	No	9	9
161	2x50	7x46	Shared	8.83	8.83	No	Yes	No	No	9	9
162	2x52	3x35	Shared	8.53	10.96	No	No	No	Yes	8	7
163	2x56	3x28	Shared	6.31	8.46	No	Yes	Yes	Yes	9	5
164	2x56	3x32	Shared	5.84	7	No	Yes	No	No	9	9
165	2x59	E1x52	Shared	10.72	3.22	No	No	No	No	7	7
166	2x59	3x28	Shared	6.19	5.16	No	No	Yes	Yes	7	5
167	2x60	3x28	Shared	5.09	5.09	No	No	Yes	Yes	8	5
168	2x60	7x42	Shared	7.63	7.63	No	No	Yes	Yes	8	8
169	2x63	E1x50	Shared	7.91	3.39	No	No	Yes	Yes	6	9
170	2x64	7x35	Shared	13.5	6.37	No	No	No	No	6	5
171	E1x49	E1x51	Shared	5.96	9.93	No	No	No	No	4	5
172	3x24	E1x50	Shared	4.69	2.81	Yes	No	Yes	Yes	5	9
173	3x25	E1x50	Shared	5.22	3.92	No	No	Yes	Yes	9	9
174	3x28	E1x50	Shared	11.58	5.79	Yes	Yes	Yes	Yes	5	9
175	E1x50	E2x50	Shared	16.98	13.06	Yes	Yes	No	No	9	9
176	3x25	E2x50	Shared	7.28	7.28	No	No	No	No	9	9
177	3x29	E2x50	Shared	4.76	3.17	No	No	No	No	7	9
178	3x31	3x35	Shared	12.18	6.09	No	No	No	Yes	6	7
179	3x32	7x42	Shared	5.75	8.05	No	No	Yes	Yes	9	8
180	3x37	5x461	Shared	9.59	7.99	No	No	No	No	8	8
181	3x38	4x50	Shared	11.12	12.36	No	No	Yes	No	8	9
182	3x38	4x53	Shared	6.52	1.71	No	No	No	No	8	8
183	3x41	4x49	Shared	4.81	4.81	No	No	No	No	8	8
184	3x42	4x49	Shared	6.92	6.92	Yes	Yes	No	No	8	8
185	3x42	4x50	Shared	5.29	10.58	Yes	Yes	Yes	No	8	9
186	3x47	5x57	Shared	8.08	4.85	No	No	No	No	9	8
187	3x48	3x52	Shared	9.11	15.94	No	No	No	No	8	5
188	3x49	I2x53	Shared	9.2	4.6	Yes	No	No	Yes	9	9
189	3x49	I2x57	Shared	13.1	13.1	Yes	No	Yes	Yes	9	8
190	3x51	3x52	Shared	4.82	4.82	Yes	Yes	No	No	9	5
191	3x51	3x55	Shared	8.74	10.17	Yes	Yes	No	No	9	8
192	3x51	5x60	Shared	12.35	8.23	Yes	Yes	No	No	9	7
193	3x51	5x61	Shared	4.84	2.42	Yes	Yes	No	No	9	9
194	3x52	I2x53	Shared	12.54	15.43	No	No	No	Yes	5	9
195	3x53	I2x57	Shared	7.91	4.15	No	No	Yes	Yes	8	8
196	I2x53	I2x57	Shared	10.29	13.38	No	Yes	Yes	Yes	9	8
197	4x59	4x60	Shared	5.84	5.84	No	No	No	No	9	8
198	5x39	E2	Shared	11.63	5.64	Yes	Yes	Yes	No	7	5
199	5x36	5x38	Shared	8.72	4.36	No	No	No	No	6	5
200	5x38	5x39	Shared	5.79	6.75	No	No	Yes	Yes	5	7
201	5x39	5x43	Shared	12.72	13.99	Yes	Yes	No	No	7	8
202	5x40	6x55	Shared	14.51	13.3	No	No	Yes	No	7	8
203	5x40	6x59	Shared	5.29	1.62	No	No	No	No	7	7
204	5x44	6x55	Shared	5.38	5.09	No	No	Yes	No	8	8
205	5x47	5x48	Shared	10.72	6.43	Yes	Yes	No	Yes	8	7
206	5x47	5x51	Shared	8.38	11.17	Yes	Yes	No	No	8	7
207	5x47	6x49	Shared	5.36	6.43	Yes	Yes	No	Yes	8	7
208	5x47	6x52	Shared	22.51	24.65	Yes	Yes	Yes	No	8	8
209	5x48	6x56	Shared	6.61	6.61	No	Yes	No	No	7	7
210	5x58	6x41	Shared	8.38	3.63	Yes	Yes	No	No	9	8
211	6x35	6x39	Shared	6.55	7.87	No	No	No	No	7	8
212	6x40	7x53	Shared	5.05	3.79	No	No	Yes	Yes	9	9
213	6x43	7x52	Shared	4.61	3.07	No	No	No	No	7	9
214	6x44	6x48	Shared	10.31	7.02	Yes	Yes	Yes	Yes	9	8
215	6x47	7x45	Shared	9.45	3.15	No	No	No	No	9	9
216	6x48	6x52	Shared	6.01	7.02	Yes	Yes	Yes	No	8	8
217	6x48	7x41	Shared	11.26	4.22	Yes	Yes	No	No	8	8
218	6x49	6x53	Shared	11.79	1.07	No	Yes	No	No	7	7
219	6x50	7x37	Shared	10.11	10.11	No	No	No	Yes	9	6
220	6x51	7x34	Shared	8.57	7.5	Yes	Yes	No	No	8	5
221	6x51	7x38	Shared	7.5	8.57	Yes	Yes	Yes	No	8	6
222	6x53	6x57	Shared	6.09	3.65	No	No	No	No	7	6
223	6x61	E3	Shared	9.09	3.7	No	No	Yes	No	7	4
224	7x33	7x37	Shared	6.09	3.65	No	No	No	Yes	5	6
225	7x36	7x40	Shared	7.54	6.28	No	No	No	No	6	8
226	7x39	7x42	Shared	13.5	7.72	Yes	No	Yes	Yes	8	8
227	7x54	8x54	Shared	9.08	6.49	No	No	No	No	9	8
228	7x55	7x56	Shared	7.87	3.77	No	No	No	No	7	8
229	8x47	8x49	Shared	6.73	8.08	No	No	Yes	No	9	8
230	8x47	8x50	Shared	8.46	7.25	No	No	Yes	Yes	9	9
231	2x41	4x42	Shared	4.47	5.71	No	No	No	No	7	8
232	1x55	8x57	Shared	4.42	2.85	No	No	No	No	6	8
233	2x55	2x551	Shared	4.42	2.95	No	No	No	No	6	6
234	1x43	2x57	Shared	4.37	5.89	No	No	Yes	No	8	8
235	1x52	8x57	Shared	4.28	2.85	No	No	No	No	8	8
236	1x49	7x50	Shared	4.06	4.06	No	No	No	No	9	9
237	6x54	7x37	Shared	3.96	3.96	No	No	No	Yes	6	6
238	6x36	7x56	Shared	3.93	11.8	No	No	No	No	9	8
239	3x40	6x44	Shared	3.89	3.77	No	No	Yes	Yes	9	9
240	2x42	4x46	Shared	3.77	2.51	Yes	Yes	No	No	8	9
241	3x40	5x50	Shared	3.74	3.39	No	No	No	No	9	9
242	1x52	8x54	Shared	3.65	3.65	No	No	No	No	8	8
243	1x53	7x50	Shared	3.53	1.77	No	No	No	No	9	9
244	7x30	E3	Shared	3.53	1.77	No	No	Yes	No	7	4
245	4x38	4x39	Shared	3.5	1.75	No	No	No	No	8	6
246	8x48	8x51	Shared	3.5	2.34	No	No	No	No	5	9
247	1x56	8x53	Shared	3.42	1.79	No	No	No	No	9	8
248	1x46	2x54	Shared	3.36	3.36	No	No	No	No	8	8
249	6x60	6x61	Shared	3.27	1.64	No	No	No	No	5	7
250	2x53	7x46	Shared	3.23	6.46	No	No	No	No	9	9
251	3x54	5x64	Shared	3.21	4.61	No	No	No	No	8	7
252	1x54	1x58	Shared	2.98	2.85	No	No	No	No	7	5
253	2x42	3x45	Shared	2.77	2.77	Yes	Yes	No	No	8	8
254	5x52	5x56	Shared	2.77	1.38	No	No	No	No	5	5
255	1x45	7x51	Shared	2.62	2.62	No	No	No	No	5	6
256	2x49	4x50	Shared	2.59	2.59	No	No	Yes	No	9	9
257	3x44	5x50	Shared	1.88	3.77	No	No	No	No	8	9
258	5x49	5x50	Shared	1.87	1.87	No	No	No	No	7	9
259	1x48	1x49	Shared	1.84	1.51	No	No	No	No	6	9
260	5x45	5x46	Shared	1.76	3.53	No	No	No	No	5	6
261	1x36	2x61	Shared	1.58	4.73	No	No	No	No	6	8
262	I2x52	I2x56	Shared	1.35	1.35	No	No	No	No	6	5
263	4x38	4x40	Shared	1.29	1.29	No	No	No	No	8	7
264	1x36	2x65	alpha2_on	0	3.15	No	No	No	No	6	7
265	1x42	7x47	alpha2_on	0	4.5	No	No	No	No	7	8
266	1x43	1x47	alpha2_on	0	2.94	No	No	No	No	8	7
267	1x46	1x50	alpha2_on	0	4.39	No	No	No	Yes	8	9
268	1x53	7x54	alpha2_on	0	3.17	No	No	No	No	9	9
269	1x54	2x47	alpha2_on	0	3.25	No	No	No	No	7	9
270	1x55	1x59	alpha2_on	0	2.95	No	No	No	No	6	7
271	1x57	2x40	alpha2_on	0	2.96	No	No	No	No	9	9
272	I1x48	I1x51	alpha2_on	0	7.46	No	No	No	No	8	8
273	2x40	I1x50	alpha2_on	0	5.49	No	No	No	No	9	9
274	2x38	2x39	alpha2_on	0	3.16	No	No	No	No	7	8
275	2x40	8x50	alpha2_on	0	6.04	No	No	Yes	Yes	9	9
276	2x43	8x50	alpha2_on	0	3.65	No	No	Yes	Yes	8	9
277	2x46	2x50	alpha2_on	0	4.07	No	No	No	Yes	9	9
278	2x46	3x39	alpha2_on	0	3	No	No	No	No	9	9
279	2x46	7x49	alpha2_on	0	6.87	No	No	No	No	9	9
280	2x50	3x39	alpha2_on	0	2.94	No	Yes	No	No	9	9
281	2x50	7x49	alpha2_on	0	10.77	No	Yes	No	No	9	9
282	2x51	2x55	alpha2_on	0	3.04	No	No	No	No	8	6
283	2x551	2x56	alpha2_on	0	2.85	No	No	No	Yes	6	9
284	2x551	3x35	alpha2_on	0	4.87	No	No	No	Yes	6	7
285	2x56	7x42	alpha2_on	0	3.63	No	Yes	Yes	Yes	9	8
286	2x57	2x58	alpha2_on	0	3.39	Yes	No	No	No	8	9
287	2x64	7x39	alpha2_on	0	4.36	No	No	Yes	No	6	8
288	2x66	E1x49	alpha2_on	0	4.69	No	No	No	No	6	4
289	E1x51	E1x52	alpha2_on	0	14.44	No	No	No	No	5	7
290	3x21	3x24	alpha2_on	0	23.99	No	No	Yes	No	8	5
291	3x25	3x29	alpha2_on	0	3.17	No	No	No	No	9	7
292	3x29	E2x52	alpha2_on	0	4.15	No	No	No	No	7	7
293	3x34	3x35	alpha2_on	0	6.09	No	No	No	Yes	8	7
294	3x34	4x57	alpha2_on	0	10.51	No	No	No	No	8	8
295	3x37	4x56	alpha2_on	0	6.08	No	No	No	No	8	8
296	3x37	Lig	alpha2_on	0	3.61	No	No	Yes	Yes	8	0
297	3x40	6x48	alpha2_on	0	8.22	No	No	Yes	Yes	9	8
298	3x42	4x46	alpha2_on	0	3.98	Yes	Yes	No	No	8	9
299	3x43	7x53	alpha2_on	0	3.52	No	No	Yes	Yes	9	9
300	3x44	5x54	alpha2_on	0	3.24	No	No	No	Yes	8	9
301	3x46	3x50	alpha2_on	0	5.01	No	No	Yes	No	9	9
302	3x47	5x54	alpha2_on	0	4.6	No	No	No	Yes	9	9
303	3x47	5x58	alpha2_on	0	11.45	No	No	Yes	Yes	9	9
304	3x50	7x53	alpha2_on	0	8.23	Yes	No	Yes	Yes	9	9
305	3x51	5x57	alpha2_on	0	6.31	Yes	Yes	No	No	9	8
306	3x56	I2x52	alpha2_on	0	8.14	No	No	No	No	7	6
307	3x56	I2x53	alpha2_on	0	13.38	No	No	No	Yes	7	9
308	4x58	4x59	alpha2_on	0	3.28	No	No	No	No	6	9
309	4x58	4x62	alpha2_on	0	8.56	No	No	No	No	6	5
310	4x59	5x39	alpha2_on	0	9.74	No	No	Yes	Yes	9	7
311	4x60	5x39	alpha2_on	0	6.95	No	No	Yes	Yes	8	7
312	5x38	E2	alpha2_on	0	6.75	No	No	Yes	No	5	5
313	E2	E2x51	alpha2_on	0	5.42	Yes	No	No	No	5	3
314	5x41	6x59	alpha2_on	0	3.15	No	No	No	No	7	7
315	5x44	5x48	alpha2_on	0	5.28	No	No	No	Yes	8	7
316	5x44	6x56	alpha2_on	0	4.89	No	No	No	No	8	7
317	5x45	5x48	alpha2_on	0	3.77	No	No	No	Yes	5	7
318	5x461	Lig	alpha2_on	0	6.13	No	No	Yes	Yes	8	0
319	5x47	6x44	alpha2_on	0	5.36	Yes	Yes	Yes	Yes	8	9
320	5x47	6x48	alpha2_on	0	4.01	Yes	Yes	Yes	Yes	8	8
321	5x51	5x55	alpha2_on	0	3.27	No	No	No	No	7	6
322	5x54	5x58	alpha2_on	0	3.59	No	Yes	Yes	Yes	9	9
323	5x54	6x44	alpha2_on	0	6.22	No	Yes	Yes	Yes	9	9
324	5x55	6x41	alpha2_on	0	2.94	No	No	No	No	6	8
325	5x58	6x40	alpha2_on	0	5.05	Yes	Yes	No	No	9	9
326	5x61	6x37	alpha2_on	0	2.85	No	No	No	No	9	8
327	5x62	5x66	alpha2_on	0	8.36	No	Yes	No	No	6	7
328	5x62	6x33	alpha2_on	0	4.13	No	Yes	No	No	6	8
329	5x62	6x34	alpha2_on	0	7.49	No	Yes	No	No	6	8
330	5x62	6x37	alpha2_on	0	3.52	No	Yes	No	No	6	8
331	5x65	6x33	alpha2_on	0	5.55	No	No	No	No	8	8
332	5x69	6x26	alpha2_on	0	13.2	No	No	No	No	5	5
333	6x30	6x33	alpha2_on	0	3.5	No	No	No	No	8	8
334	6x48	7x45	alpha2_on	0	9.04	Yes	Yes	No	No	8	9
335	6x48	Lig	alpha2_on	0	4.65	Yes	Yes	Yes	Yes	8	0
336	6x49	6x50	alpha2_on	0	4.33	No	Yes	No	No	7	9
337	6x51	7x37	alpha2_on	0	3.22	Yes	Yes	No	Yes	8	6
338	7x34	7x35	alpha2_on	0	4.68	No	No	No	No	5	5
339	7x38	7x42	alpha2_on	0	14.44	Yes	No	Yes	Yes	6	8
340	7x45	7x49	alpha2_on	0	13.62	No	No	No	No	9	9
341	7x52	7x53	alpha2_on	0	4.84	No	No	Yes	Yes	9	9
342	7x54	8x50	alpha2_on	0	3.89	No	No	Yes	Yes	9	9
343	8x53	8x56	alpha2_on	0	4.15	No	No	No	No	8	6
344	8x57	8x58	alpha2_on	0	2.85	No	No	No	No	8	8
345	2x41	4x43	alpha2_on	0	2.82	No	No	No	No	7	5
346	4x40	4x44	alpha2_on	0	2.79	No	No	No	No	7	3
347	2x62	E1x51	alpha2_on	0	2.67	No	No	No	No	7	5
348	1x60	8x56	alpha2_on	0	2.64	No	No	No	No	7	6
349	6x45	6x49	alpha2_on	0	2.62	No	No	No	Yes	8	7
350	4x41	4x45	alpha2_on	0	2.51	No	No	No	No	7	7
351	5x69	6x29	alpha2_on	0	2.41	No	No	No	No	5	7
352	7x36	7x37	alpha2_on	0	2.14	No	No	No	Yes	6	6
353	3x30	4x60	alpha2_on	0	1.87	No	No	No	No	8	8
354	6x47	7x43	alpha2_on	0	1.82	No	No	No	No	9	6
355	6x41	6x42	alpha2_on	0	1.76	No	No	No	No	8	7
356	4x54	4x57	alpha2_on	0	1.71	No	No	No	No	7	8
357	3x53	3x54	alpha2_on	0	1.7	No	No	No	No	8	8
358	1x31	1x32	alpha2_on	0	1.68	No	No	No	No	5	5
359	5x43	5x461	alpha2_on	0	1.63	No	No	No	No	8	8
360	2x54	2x57	alpha2_on	0	1.62	No	No	Yes	No	8	8
361	6x36	6x40	alpha2_on	0	1.6	No	No	No	No	9	9
362	6x39	6x43	alpha2_on	0	1.6	No	No	No	No	8	7
363	6x47	7x48	alpha2_on	0	1.59	No	No	No	No	9	7
364	1x33	2x65	alpha2_on	0	1.58	No	No	No	No	6	7
365	3x30	4x61	alpha2_on	0	1.58	No	No	No	No	8	7
366	5x53	5x57	alpha2_on	0	1.54	No	No	No	No	7	8
367	4x48	4x52	alpha2_on	0	1.52	No	No	No	No	5	6
368	3x27	3x31	alpha2_on	0	1.49	No	No	No	No	6	6
369	1x40	2x61	alpha2_on	0	1.47	No	No	No	No	5	8
370	1x44	1x47	alpha2_on	0	1.43	No	No	No	No	5	7
371	5x55	5x59	alpha2_on	0	1.43	No	No	No	No	6	4
372	8x59	CT	alpha2_on	0	1.39	No	No	No	No	4	5
373	6x27	6x30	alpha2_on	0	1.33	No	No	No	No	5	8
374	8x47	8x48	alpha2_on	0	1.32	No	No	No	No	9	5
375	5x69	6x30	alpha2_on	0	1.31	No	No	No	No	5	8
376	5x64	5x67	alpha2_on	0	1.25	No	No	No	No	7	5
377	7x31	7x35	alpha2_on	0	1.24	No	No	No	No	2	5
378	1x41	1x44	alpha2_on	0	1.22	No	No	No	No	4	5
379	5x62	5x63	alpha2_on	0	1.17	No	Yes	No	No	6	5
380	5x70	6x26	alpha2_on	0	1.17	No	No	No	No	0	5
381	3x22	E1x50	alpha2_on	0	1	No	No	Yes	Yes	4	9

Orange: nodes, hubs and links specific of alpha2_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of alpha2_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	alpha2_off Avg Int. Strength	alpha2_on Avg Int. Strength	alpha2_off Num Of Links	alpha2_on Num Of Links	ConSurf
1	NT	alpha2_off	7.35444	0	9	0	4
2	2x57	alpha2_off	6.41	3.63333	4	3	8
3	3x24	alpha2_off	9.8975	13.4	4	2	5
4	3x49	alpha2_off	8.075	7.49333	4	3	9
5	3x50	alpha2_off	7.81	6.62	4	2	9
6	4x50	alpha2_off	5.435	8.51	6	3	9
7	E2	alpha2_off	11.1657	5.93667	7	3	5
8	6x52	alpha2_off	12.24	11.8833	4	3	8
9	6x55	alpha2_off	10.095	9.63667	4	3	8
10	E3	alpha2_off	7.22	2.735	5	2	4
11	7x38	alpha2_off	8.58	12.64	4	3	6
12	7x39	alpha2_off	7.3075	6.37667	4	3	8
13	8x49	alpha2_off	7.5975	9.195	4	2	8
14	Lig	Shared	11.6211	7.65091	9	11	0
15	2x42	Shared	4.68	4.39833	6	6	8
16	E1x50	Shared	9.46143	4.995	7	6	9
17	3x28	Shared	6.772	6.125	5	4	5
18	3x42	Shared	6.7525	7.1125	4	4	8
19	3x51	Shared	7.6875	6.39	4	5	9
20	I2x57	Shared	12.372	10.5775	5	4	8
21	5x39	Shared	9	8.614	4	5	7
22	5x47	Shared	11.7425	9.675	4	6	8
23	5x58	Shared	7.64	5.93	4	4	9
24	6x44	Shared	7.93	5.5925	5	4	9
25	6x48	Shared	9.18	6.31143	4	7	8
26	6x51	Shared	10.79	7.805	5	4	8
27	7x42	Shared	8.188	7.86833	5	6	8
28	7x53	Shared	8.302	5.095	5	4	9
29	8x50	Shared	11.6775	6.602	4	5	9
30	1x50	alpha2_on	9.40333	8.15	3	4	9
31	2x50	alpha2_on	10.475	7.746	2	5	9
32	2x56	alpha2_on	6.075	5.485	2	4	9
33	3x35	alpha2_on	8.24	7.0025	3	4	7
34	I2x53	alpha2_on	10.6767	11.6975	3	4	9
35	5x48	alpha2_on	8.665	5.5225	2	4	7
36	5x54	alpha2_on	4.41	4.4125	2	4	9
37	5x62	alpha2_on	3.645	4.934	2	5	6
38	6x49	alpha2_on	8.575	3.6125	2	4	7
39	7x37	alpha2_on	6.72	4.616	3	5	6

Orange: nodes, hubs and links specific of alpha2_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of alpha2_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	alpha2_off Recurrence	alpha2_on Recurrence	alpha2_off Hub1?	alpha2_on Hub1?	alpha2_off Hub2?	alpha2_on Hub2?	ConSurf1	ConSurf2
1	3x33	Lig	alpha2_off	11.6506	1.49095	No	No	Yes	Yes	8	0
2	3x36	Lig	alpha2_off	42.4287	1.66185	No	No	Yes	Yes	8	0
3	E2x52	Lig	alpha2_off	21.0108	0	No	No	Yes	Yes	7	0
4	6x52	Lig	alpha2_off	44.3169	9.26985	Yes	No	Yes	Yes	8	0
5	7x38	Lig	alpha2_off	14.5933	0.995934	Yes	No	Yes	Yes	6	0
6	5x39	E2x52	alpha2_off	19.3188	0	Yes	Yes	No	No	7	7
7	5x39	E2	alpha2_off	14.9023	3.14102	Yes	Yes	Yes	No	7	5
8	7x35	7x38	alpha2_off	12.2097	0	No	No	Yes	No	5	6
9	2x64	7x35	alpha2_off	10.8414	0.777889	No	No	No	No	6	5
10	1x39	7x39	alpha2_off	12.8105	8.88679	No	No	Yes	No	7	8
11	1x53	7x53	alpha2_off	17.3177	0	No	No	Yes	Yes	9	9
12	7x53	8x50	alpha2_off	31.3372	0	Yes	Yes	Yes	Yes	9	9
13	8x47	8x50	alpha2_off	43.5126	7.74353	No	No	Yes	Yes	9	9
14	6x33	8x47	alpha2_off	51.6001	0	No	No	No	No	8	9
15	6x33	6x37	alpha2_off	51.7521	0	No	No	No	No	8	8
16	3x46	6x37	alpha2_off	54.7267	0	No	No	No	No	9	8
17	2x42	3x49	alpha2_off	70.9262	5.1211	Yes	Yes	Yes	No	8	9
18	3x49	I2x53	alpha2_off	76.5517	4.33143	Yes	No	No	Yes	9	9
19	5x58	5x61	alpha2_off	91.7727	0	Yes	Yes	No	No	9	9
20	5x58	6x41	alpha2_off	93.4991	4.13696	Yes	Yes	No	No	9	8
21	3x43	6x41	alpha2_off	95.2966	0	No	No	No	No	9	8
22	3x43	6x44	alpha2_off	96.3854	0	No	No	Yes	Yes	9	9
23	3x36	6x48	alpha2_off	42.4925	0	No	No	Yes	Yes	8	8
24	6x48	6x52	alpha2_off	58.1427	0.76021	Yes	Yes	Yes	No	8	8
25	2x37	2x39	alpha2_off	17.4575	1.59114	No	No	No	No	8	8
26	2x39	3x49	alpha2_off	10.6207	0	No	No	Yes	No	8	9
27	2x37	2x38	alpha2_off	15.7336	0	No	No	No	No	8	7
28	2x38	4x39	alpha2_off	14.0048	6.31151	No	No	No	No	7	6
29	2x45	4x46	alpha2_off	18.4016	1.54989	No	No	No	No	9	9
30	2x45	4x50	alpha2_off	12.6217	0	No	No	Yes	No	9	9
31	3x33	4x57	alpha2_off	10.6158	0	No	No	No	No	8	8
32	4x38	4x39	alpha2_off	10.5324	4.74984	No	No	No	No	8	6
33	3x32	Lig	Shared	21.4939	33.9148	No	No	Yes	Yes	9	0
34	1x50	2x50	Shared	10.8683	55.5955	No	Yes	No	Yes	9	9
35	1x50	7x50	Shared	12.7811	36.7376	No	Yes	No	No	9	9
36	1x53	7x50	Shared	16.5477	32.8658	No	No	No	No	9	9
37	2x42	3x46	Shared	55.4256	21.8398	Yes	Yes	No	No	8	9
38	3x52	I2x53	Shared	87.5917	24.8748	No	No	No	Yes	5	9
39	3x51	3x52	Shared	88.5088	27.1613	Yes	Yes	No	No	9	5
40	3x51	5x61	Shared	91.9812	20.7201	Yes	Yes	No	No	9	9
41	6x44	6x48	Shared	100	73.9407	Yes	Yes	Yes	Yes	9	8
42	I2x53	I2x57	Shared	10.5716	16.041	No	Yes	Yes	Yes	9	8
43	2x42	4x46	Shared	19.3212	13.9431	Yes	Yes	No	No	8	9
44	2x56	3x28	Shared	19.7798	43.9448	No	Yes	Yes	Yes	9	5
45	2x56	3x32	Shared	20.67	33.0308	No	Yes	No	No	9	9
46	2x59	3x28	Shared	13.1367	22.8711	No	No	Yes	Yes	7	5
47	3x28	E1x50	Shared	20.6577	40.9394	Yes	Yes	Yes	Yes	5	9
48	2x60	7x42	Shared	21.8961	23.5547	No	No	Yes	Yes	8	8
49	7x42	Lig	Shared	31.4206	64.0167	Yes	Yes	Yes	Yes	8	0
50	2x60	3x28	Shared	21.0501	22.5057	No	No	Yes	Yes	8	5
51	7x39	7x42	alpha2_on	6.79271	12.0455	Yes	No	Yes	Yes	8	8
52	6x48	Lig	alpha2_on	0	100	Yes	Yes	Yes	Yes	8	0
53	6x48	7x45	alpha2_on	0	67.1224	Yes	Yes	No	No	8	9
54	7x45	7x49	alpha2_on	0	63.1858	No	No	No	No	9	9
55	2x50	7x49	alpha2_on	0	59.5674	No	Yes	No	No	9	9
56	1x46	1x50	alpha2_on	0	18.0977	No	No	No	Yes	8	9
57	1x46	2x54	alpha2_on	2.0182	10.7608	No	No	No	No	8	8
58	1x53	7x54	alpha2_on	0	31.5517	No	No	No	No	9	9
59	7x54	8x50	alpha2_on	0	22.1934	No	No	Yes	Yes	9	9
60	5x54	6x44	alpha2_on	0	80.9476	No	Yes	Yes	Yes	9	9
61	3x47	5x54	alpha2_on	0	44.9231	No	No	No	Yes	9	9
62	3x47	5x57	alpha2_on	1.02504	46.8384	No	No	No	No	9	8
63	3x51	5x57	alpha2_on	0	44.8936	Yes	Yes	No	No	9	8
64	2x39	I2x57	alpha2_on	8.38667	10.7549	No	No	Yes	Yes	8	8
65	5x54	5x58	alpha2_on	0	35.4234	No	Yes	Yes	Yes	9	9
66	5x58	6x40	alpha2_on	0	34.7398	Yes	Yes	No	No	9	9
67	6x40	7x53	alpha2_on	7.9232	30.3848	No	No	Yes	Yes	9	9
68	3x50	7x53	alpha2_on	0	23.7138	Yes	No	Yes	Yes	9	9
69	3x46	3x50	alpha2_on	0	22.8063	No	No	Yes	No	9	9
70	3x42	4x46	alpha2_on	0	10.8846	Yes	Yes	No	No	8	9
71	2x56	7x42	alpha2_on	0	36.1483	No	Yes	Yes	Yes	9	8
72	2x551	2x56	alpha2_on	0	25.3344	No	No	No	Yes	6	9
73	2x551	3x35	alpha2_on	0	17.8561	No	No	No	Yes	6	7
74	2x59	E1x52	alpha2_on	5.55923	19.0877	No	No	No	No	7	7
75	E1x51	E1x52	alpha2_on	0	15.2926	No	No	No	No	5	7
76	3x25	E1x50	alpha2_on	1.92501	11.0967	No	No	Yes	Yes	9	9
77	E1x50	E2x50	alpha2_on	1.96425	11.0967	Yes	Yes	No	No	9	9
78	5x461	Lig	alpha2_on	0	20.2723	No	No	Yes	Yes	8	0
79	5x43	5x461	alpha2_on	0	18.8992	No	No	No	No	8	8
80	5x39	5x43	alpha2_on	1.05692	17.3611	Yes	Yes	No	No	7	8
81	5x47	6x48	alpha2_on	0	13.9843	Yes	Yes	Yes	Yes	8	8
82	5x47	6x49	alpha2_on	6.2287	11.9041	Yes	Yes	No	Yes	8	7
83	5x61	6x37	alpha2_on	0	19.2645	No	No	No	No	9	8
84	5x62	6x37	alpha2_on	0	17.9386	No	Yes	No	No	6	8
85	5x62	6x33	alpha2_on	0	12.1339	No	Yes	No	No	6	8
86	6x51	7x37	alpha2_on	0	10.0654	Yes	Yes	No	Yes	8	6
87	6x51	Lig	alpha2_on	0.40462	12.7468	Yes	Yes	Yes	Yes	8	0

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
3x32	Lig	Shared	29.1	9.97	1	1	1	0
3x33	Lig	Shared	11.34	3.65	0	0	1	0
3x36	Lig	Shared	6.59	9.07	0	0	1	0
E2x52	Lig	alpha2_off	6.7	0	0	0	1	0
6x51	Lig	Shared	12.64	11.93	1	1	1	0
6x52	Lig	Shared	7.58	3.98	1	1	1	0
6x55	Lig	Shared	8.11	10.52	1	0	1	0
7x38	Lig	Shared	16.85	14.91	1	1	1	0
7x42	Lig	Shared	5.68	5.74	1	1	1	0
2x56	3x32	Shared	5.84	7	0	1	2	1
2x57	7x39	alpha2_off	5.82	0	1	0	2	2
2x57	7x42	alpha2_off	8.38	0	1	0	2	1
2x60	7x42	Shared	7.63	7.63	0	0	2	1
3x32	7x42	Shared	5.75	8.05	1	1	1	1
3x33	4x57	alpha2_off	4.85	0	0	0	1	2
3x36	6x48	alpha2_off	9.14	0	0	0	1	1
3x37	4x57	alpha2_off	6.4	0	0	1	1	2
3x37	5x461	Shared	9.59	7.99	0	1	1	1
5x39	E2x52	alpha2_off	5.86	0	2	2	2	1
5x39	5x43	Shared	12.72	13.99	2	2	2	2
5x40	6x55	Shared	14.51	13.3	0	0	2	1
5x44	6x55	Shared	5.38	5.09	0	1	2	1
5x47	6x52	Shared	22.51	24.65	0	1	2	1
6x44	6x48	Shared	10.31	7.02	0	1	2	1
6x44	7x45	alpha2_off	11.3	0	0	1	2	2
6x48	6x52	Shared	6.01	7.02	0	1	1	1
6x48	7x41	Shared	11.26	4.22	0	1	1	2
6x51	6x52	alpha2_off	12.86	0	1	1	1	1
6x51	6x55	alpha2_off	12.38	0	1	1	1	1
6x51	7x34	Shared	8.57	7.5	1	1	1	2
6x51	7x38	Shared	7.5	8.57	1	1	1	1
7x35	7x38	alpha2_off	4.96	0	0	0	2	1
7x38	7x39	alpha2_off	5.01	0	1	1	1	2
7x39	7x42	Shared	13.5	7.72	1	0	2	1
3x40	6x44	Shared	3.89	3.77	0	1	2	2
4x56	5x461	alpha2_off	3.1	0	0	0	2	1
4x62	E2x52	alpha2_off	2.98	0	0	0	2	1
2x56	7x42	alpha2_on	0	3.63	0	1	2	1
3x29	E2x52	alpha2_on	0	4.15	0	4	2	1
3x37	4x56	alpha2_on	0	6.08	0	1	1	2
3x37	Lig	alpha2_on	0	3.61	0	1	1	0
3x40	6x48	alpha2_on	0	8.22	0	1	2	1
5x461	Lig	alpha2_on	0	6.13	0	1	1	0
5x47	6x44	alpha2_on	0	5.36	0	1	2	2
5x47	6x48	alpha2_on	0	4.01	0	1	2	1
6x48	7x45	alpha2_on	0	9.04	0	1	1	2
6x48	Lig	alpha2_on	0	4.65	0	1	1	0
6x51	7x37	alpha2_on	0	3.22	1	1	1	2
7x34	7x35	alpha2_on	0	4.68	0	0	2	2
7x38	7x42	alpha2_on	0	14.44	1	1	1	1
5x43	5x461	alpha2_on	0	1.63	0	0	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	alpha2_off	alpha2c_off
	alpha2_on	alpha2b_on

Network Difference
Value	alpha2_off	alpha2_on
I_min	4.54	2.85
Number of Linked Nodes	240	229
Number of Specific Nodes	25 (10.42%)	14 (6.11%)
Number of Shared Nodes	215 (89.58%)	215 (93.89%)
Number of Links	263	249
Number of Specific Links	132 (50.19%)	118 (47.39%)
Number of Shared Links	131 (49.81%)	131 (52.61%)
Number of Hubs	29	26
Number of Specific Hubs	13 (44.83%)	10 (38.46%)
Number of Shared Hubs	16 (55.17%)	16 (61.54%)
Average % Shared Neighbours (Jaccard)	34.65
Average % Shared Neighbours (Otsuka)	43.51
Average % Shared Neighbours (Overlap Coefficient)	51.91
Average % Shared Cliques (k3-6)	78.45
Graphlets Similarity	0.543373

Paths Difference
Value	alpha2_off	alpha2_on
Number Of Nodes in MetaPath	50	54
Specific Nodes in MetaPath	20 (40.00%)	24 (44.44%)
Shared Nodes in MetaPath	215 (89.58%)	215 (89.58%)
Number Of Links MetaPath	50	55
Specific Links in MetaPath	32 (64.00%)	37 (67.27%)
Shared Links in MetaPath	131 (49.81%)	131 (49.81%)
Number of Shortest Paths	58334	34797
Length Of Smallest Path	3	3
Average Path Length	17.8976	12.2268
Length of Longest Path	35	28
Minimum Path Strength	1.47	1.32
Average Path Strength	7.94591	6.41978
Maximum Path Strength	22.975	17.91
Minimum Path Correlation	0.7	0.7
Average Path Correlation	0.917489	0.919508
Maximum Path Correlation	0.99	0.99
Minimum % Of Corr. Nodes	3.84615	4.34783
Average % Of Corr. Nodes	34.3849	48.5734
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	41.7748	46.0369
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

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