psnGPCR

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Orange: nodes, hubs and links specific of alpha2_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of alpha2_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	alpha2_off Int. Strength	alpha2_on Int. Strength	alpha2_off Hub1?	alpha2_on Hub1?	alpha2_off Hub2?	alpha2_on Hub2?	ConSurf1	ConSurf2
1	2x65	NT	alpha2_off	100	0	No	No	Yes	No	7	6
2	1x34	NT	alpha2_off	100	0	No	No	Yes	No	3	6
3	2x39	3x49	alpha2_off	100	0	No	Yes	Yes	No	9	9
4	2x40	2x43	alpha2_off	100	0	No	No	No	No	9	8
5	2x42	4x46	alpha2_off	100	0	Yes	Yes	No	No	8	8
6	2x45	4x50	alpha2_off	100	0	Yes	No	Yes	No	9	9
7	2x53	2x56	alpha2_off	100	0	No	No	No	No	8	8
8	2x59	3x24	alpha2_off	100	0	No	No	Yes	No	7	6
9	2x63	E1x49	alpha2_off	100	0	No	No	No	No	8	5
10	2x63	E1x51	alpha2_off	100	0	No	No	Yes	No	8	5
11	2x64	7x31	alpha2_off	100	0	No	No	No	No	7	4
12	E1x49	E1x51	alpha2_off	100	0	No	No	Yes	No	5	5
13	E1x49	E2	alpha2_off	100	0	No	No	Yes	No	5	5
14	3x24	E1x51	alpha2_off	100	0	Yes	No	Yes	No	6	5
15	3x25	E1x51	alpha2_off	100	0	No	No	Yes	No	9	5
16	3x28	E1x51	alpha2_off	100	0	Yes	Yes	Yes	No	7	5
17	E1x51	E2x50	alpha2_off	100	0	Yes	No	No	No	5	9
18	3x28	3x29	alpha2_off	100	0	Yes	Yes	No	No	7	7
19	3x28	Lig	alpha2_off	100	0	Yes	Yes	Yes	Yes	7	0
20	3x29	E2x52	alpha2_off	100	0	No	No	No	No	7	7
21	3x34	4x50	alpha2_off	100	0	No	No	Yes	No	7	9
22	3x37	4x57	alpha2_off	100	0	No	No	No	No	8	8
23	3x38	3x42	alpha2_off	100	0	No	No	Yes	Yes	8	8
24	3x41	5x50	alpha2_off	100	0	Yes	No	No	No	7	9
25	3x43	5x54	alpha2_off	100	0	No	No	No	No	8	9
26	3x43	6x41	alpha2_off	100	0	No	No	Yes	No	8	7
27	3x49	3x50	alpha2_off	100	0	Yes	No	Yes	No	9	9
28	3x50	6x33	alpha2_off	100	0	Yes	No	No	Yes	9	8
29	3x50	6x34	alpha2_off	100	0	Yes	No	No	No	9	8
30	3x50	6x37	alpha2_off	100	0	Yes	No	No	No	9	8
31	3x55	3x56	alpha2_off	100	0	No	No	No	No	7	7
32	4x41	I2x56	alpha2_off	100	0	No	No	No	No	8	6
33	E2	E2	alpha2_off	100	0	Yes	No	Yes	No	5	5
34	E2x52	Lig	alpha2_off	100	0	No	No	Yes	Yes	7	0
35	5x36	5x38	alpha2_off	100	0	No	No	No	No	6	5
36	5x48	6x56	alpha2_off	100	0	No	Yes	No	No	7	7
37	5x54	6x41	alpha2_off	100	0	No	No	Yes	No	9	7
38	5x58	6x38	alpha2_off	100	0	Yes	Yes	No	No	9	7
39	5x58	6x41	alpha2_off	100	0	Yes	Yes	Yes	No	9	7
40	6x29	8x49	alpha2_off	100	0	No	No	Yes	No	8	8
41	6x33	6x37	alpha2_off	100	0	No	Yes	No	No	8	8
42	6x40	7x49	alpha2_off	100	0	No	No	No	Yes	8	9
43	6x40	7x52	alpha2_off	100	0	No	No	No	No	8	8
44	6x44	6x48	alpha2_off	100	0	Yes	Yes	Yes	Yes	9	9
45	6x44	7x45	alpha2_off	100	0	Yes	Yes	No	No	9	9
46	6x48	6x51	alpha2_off	100	0	Yes	Yes	Yes	Yes	9	8
47	6x54	E3	alpha2_off	100	0	No	No	Yes	No	7	5
48	7x34	E3	alpha2_off	100	0	No	No	Yes	No	6	5
49	7x30	7x33	alpha2_off	100	0	No	No	No	No	7	7
50	7x35	7x38	alpha2_off	100	0	No	No	No	No	7	7
51	7x49	7x53	alpha2_off	100	0	No	Yes	Yes	Yes	9	9
52	7x53	8x50	alpha2_off	100	0	Yes	Yes	Yes	Yes	9	8
53	E2	NT	alpha2_off	100	0	Yes	No	Yes	No	5	6
54	2x64	NT	alpha2_off	100	0	No	No	Yes	No	7	6
55	2x59	E1x52	alpha2_off	100	0	No	No	No	No	7	7
56	4x58	4x60	alpha2_off	100	0	No	No	No	No	6	8
57	5x39	E2	alpha2_off	100	0	No	Yes	Yes	No	8	5
58	6x58	6x62	alpha2_off	100	0	No	No	No	No	5	0
59	6x61	E3	alpha2_off	100	0	No	No	Yes	No	3	5
60	E3	E3	alpha2_off	100	0	Yes	No	Yes	No	5	5
61	3x39	6x44	alpha2_off	50	0	No	No	Yes	Yes	9	9
62	4x43	4x46	alpha2_off	50	0	No	No	No	No	6	8
63	4x43	4x47	alpha2_off	50	0	No	No	No	No	6	5
64	3x26	E2	alpha2_off	50	0	No	No	Yes	No	7	5
65	3x41	4x53	alpha2_off	50	0	Yes	No	No	No	7	8
66	3x46	6x37	alpha2_off	50	0	No	No	No	No	9	8
67	5x51	6x45	alpha2_off	50	0	No	No	No	No	7	7
68	5x67	5x68	alpha2_off	50	0	No	No	No	No	7	8
69	6x33	8x47	alpha2_off	50	0	No	Yes	No	No	8	9
70	3x35	4x50	alpha2_off	0	0	Yes	No	Yes	No	7	9
71	1x46	7x46	alpha2_off	50	0	No	No	No	No	8	9
72	1x53	7x53	alpha2_off	50	0	No	No	Yes	Yes	9	9
73	5x60	5x64	alpha2_off	50	0	No	No	No	No	7	7
74	3x23	3x24	alpha2_off	50	0	No	No	Yes	No	5	6
75	3x24	3x27	alpha2_off	50	0	Yes	No	No	No	6	6
76	1x42	2x57	alpha2_off	50	0	No	No	No	No	7	8
77	6x28	6x31	alpha2_off	50	0	No	No	Yes	No	5	7
78	3x50	6x30	alpha2_off	50	0	Yes	No	No	No	9	9
79	8x56	CT	alpha2_off	50	0	No	No	No	No	7	0
80	6x39	7x56	alpha2_off	0	0	No	No	No	No	7	8
81	4x38	4x41	alpha2_off	50	0	No	No	No	No	8	8
82	1x42	7x43	alpha2_off	0	0	No	No	No	No	7	7
83	1x54	2x44	alpha2_off	0	0	No	No	No	No	8	7
84	6x39	7x52	alpha2_off	50	0	No	No	No	No	7	8
85	5x57	5x61	alpha2_off	0	0	No	No	No	No	8	9
86	1x60	I1x51	alpha2_off	50	0	No	No	No	No	8	7
87	1x57	I1x51	alpha2_off	50	0	No	No	No	No	8	7
88	7x36	7x39	alpha2_off	50	0	No	No	No	No	6	7
89	5x58	5x62	alpha2_off	50	0	Yes	Yes	No	Yes	9	8
90	4x62	E2	alpha2_off	50	0	No	No	Yes	No	6	5
91	1x56	8x50	alpha2_off	0	0	No	No	Yes	Yes	9	8
92	1x56	8x53	alpha2_off	0	0	No	No	No	No	9	8
93	3x22	E2	alpha2_off	50	0	No	No	Yes	No	4	5
94	8x56	8x60	alpha2_off	50	0	No	No	No	No	7	7
95	1x35	NT	alpha2_off	0	0	No	No	Yes	No	6	6
96	2x62	2x66	alpha2_off	0	0	No	No	No	No	7	7
97	5x65	6x31	alpha2_off	0	0	No	No	Yes	No	8	7
98	3x41	4x52	alpha2_off	50	0	Yes	No	No	No	7	7
99	1x38	7x39	alpha2_off	50	0	No	No	No	No	5	7
100	2x38	I2x57	alpha2_off	50	0	No	No	Yes	Yes	7	7
101	5x41	6x60	alpha2_off	0	0	No	No	No	No	7	5
102	6x29	6x32	alpha2_off	0	0	No	No	No	No	8	9
103	8x59	8x60	alpha2_off	0	0	No	No	No	No	6	7
104	2x551	3x31	alpha2_off	0	0	No	No	No	No	7	7
105	3x41	3x44	alpha2_off	0	0	Yes	No	No	No	7	7
106	3x30	4x59	alpha2_off	0	0	No	No	No	No	8	8
107	8x51	8x55	alpha2_off	0	0	No	No	No	No	9	6
108	4x56	5x46	alpha2_off	0	0	No	No	No	No	8	6
109	1x47	2x54	alpha2_off	0	0	No	No	No	No	7	9
110	3x45	4x49	alpha2_off	0	0	No	No	No	No	8	8
111	2x45	2x48	alpha2_off	0	0	Yes	No	No	No	9	7
112	5x54	5x55	alpha2_off	0	0	No	No	No	No	9	6
113	6x31	6x34	alpha2_off	0	0	Yes	No	No	No	7	8
114	I2x51	I2x52	alpha2_off	0	0	No	No	No	No	7	6
115	2x67	E1x50	alpha2_off	0	0	No	No	Yes	Yes	6	8
116	3x21	E1x50	alpha2_off	0	0	No	No	Yes	Yes	7	8
117	2x62	E1x52	alpha2_off	0	0	No	No	No	No	7	7
118	1x31	NT	alpha2_off	0	0	No	No	Yes	No	0	6
119	1x45	7x51	alpha2_off	0	0	No	No	No	No	5	7
120	4x38	4x40	alpha2_off	0	0	No	No	No	No	8	5
121	1x33	1x34	alpha2_off	0	0	No	No	No	No	5	3
122	1x28	1x31	alpha2_off	0	0	No	No	No	No	0	0
123	1x44	1x48	alpha2_off	0	0	No	No	No	No	6	5
124	5x66	5x69	alpha2_off	0	0	No	No	No	No	8	5
125	5x52	5x53	alpha2_off	0	0	No	No	No	No	5	8
126	I1x48	I1x49	alpha2_off	0	0	No	No	No	No	8	7
127	I2x54	I2x55	alpha2_off	0	0	No	No	No	No	7	6
128	4x58	4x61	alpha2_off	0	0	No	No	No	No	6	7
129	1x39	2x61	Shared	100	100	No	No	No	No	5	8
130	1x43	2x58	Shared	100	16.6667	No	No	No	No	7	9
131	1x46	7x47	Shared	100	100	No	No	No	No	8	8
132	1x50	2x47	Shared	100	100	Yes	Yes	No	No	9	9
133	1x50	2x50	Shared	100	100	Yes	Yes	No	Yes	9	9
134	1x50	7x50	Shared	100	100	Yes	Yes	No	No	9	9
135	1x52	8x54	Shared	100	100	Yes	Yes	No	Yes	8	8
136	1x57	2x44	Shared	100	100	No	No	No	No	8	7
137	1x60	I1x50	Shared	100	100	No	No	No	No	8	9
138	2x38	4x39	Shared	100	100	No	No	No	No	7	6
139	2x39	I2x57	Shared	100	100	No	Yes	Yes	Yes	9	7
140	2x42	3x46	Shared	100	100	Yes	Yes	No	No	8	9
141	2x42	4x42	Shared	100	100	Yes	Yes	No	No	8	8
142	2x42	4x45	Shared	100	100	Yes	Yes	No	No	8	7
143	2x43	7x53	Shared	100	8.33333	No	No	Yes	Yes	8	9
144	2x45	3x42	Shared	100	100	Yes	No	Yes	Yes	9	8
145	2x45	4x46	Shared	100	100	Yes	No	No	No	9	8
146	2x50	7x46	Shared	100	100	No	Yes	No	No	9	9
147	2x52	3x35	Shared	100	100	No	No	Yes	No	8	7
148	2x53	3x35	Shared	100	50	No	No	Yes	No	8	7
149	2x55	2x551	Shared	100	33.3333	No	No	No	No	6	7
150	2x56	3x32	Shared	100	100	No	No	No	No	8	8
151	2x57	7x42	Shared	100	100	No	No	Yes	Yes	8	8
152	2x59	3x28	Shared	100	100	No	No	Yes	Yes	7	7
153	2x60	3x28	Shared	100	100	No	No	Yes	Yes	8	7
154	2x60	7x42	Shared	100	100	No	No	Yes	Yes	8	8
155	2x61	2x65	Shared	100	50	No	No	No	No	8	7
156	2x64	7x35	Shared	100	100	No	No	No	No	7	7
157	E1x50	E1x52	Shared	100	50	Yes	Yes	No	No	8	7
158	3x25	E2x50	Shared	100	100	No	No	No	No	9	9
159	3x31	3x35	Shared	100	100	No	No	Yes	No	7	7
160	3x32	7x42	Shared	100	100	No	No	Yes	Yes	8	8
161	3x32	Lig	Shared	100	100	No	No	Yes	Yes	8	0
162	3x33	4x57	Shared	100	50	No	No	No	No	8	8
163	3x33	Lig	Shared	100	100	No	No	Yes	Yes	8	0
164	3x36	6x48	Shared	100	100	No	No	Yes	Yes	7	9
165	3x37	5x461	Shared	100	100	No	No	No	No	8	8
166	3x38	4x50	Shared	100	100	No	No	Yes	No	8	9
167	3x38	4x53	Shared	100	16.6667	No	No	No	No	8	8
168	3x42	4x49	Shared	100	100	Yes	Yes	No	No	8	8
169	3x42	4x50	Shared	100	100	Yes	Yes	Yes	No	8	9
170	3x43	6x44	Shared	100	100	No	No	Yes	Yes	8	9
171	3x47	5x57	Shared	100	100	No	No	No	No	9	8
172	3x48	3x52	Shared	100	100	No	No	No	Yes	7	6
173	3x49	I2x53	Shared	100	100	Yes	No	No	Yes	9	9
174	3x51	3x52	Shared	100	100	No	Yes	No	Yes	8	6
175	3x51	3x55	Shared	100	100	No	Yes	No	No	8	7
176	3x51	5x60	Shared	100	100	No	Yes	No	No	8	7
177	3x52	I2x53	Shared	100	100	No	Yes	No	Yes	6	9
178	3x56	I2x52	Shared	100	100	No	No	No	No	7	6
179	I2x53	I2x57	Shared	100	100	No	Yes	Yes	Yes	9	7
180	I2x54	I2x57	Shared	100	0	No	No	Yes	Yes	7	7
181	E2	E2x51	Shared	100	50	Yes	No	No	No	5	4
182	5x36	E2	Shared	100	100	No	No	Yes	No	6	5
183	5x39	5x43	Shared	100	100	No	Yes	No	No	8	9
184	5x40	6x55	Shared	100	100	No	No	No	Yes	7	8
185	5x47	5x48	Shared	100	100	Yes	Yes	No	Yes	9	7
186	5x47	5x51	Shared	100	100	Yes	Yes	No	No	9	7
187	5x47	6x49	Shared	100	100	Yes	Yes	No	Yes	9	7
188	5x47	6x52	Shared	100	100	Yes	Yes	Yes	Yes	9	8
189	5x58	5x61	Shared	100	50	Yes	Yes	No	No	9	9
190	5x62	5x66	Shared	100	100	No	Yes	No	No	8	8
191	6x27	6x31	Shared	100	50	No	No	Yes	No	6	7
192	6x35	6x39	Shared	100	100	No	No	No	No	7	7
193	6x43	7x52	Shared	100	100	No	No	No	No	8	8
194	6x47	7x45	Shared	100	100	No	No	No	No	8	9
195	6x48	6x52	Shared	100	100	Yes	Yes	Yes	Yes	9	8
196	6x48	7x41	Shared	100	100	Yes	Yes	No	No	9	8
197	6x49	6x53	Shared	100	100	No	Yes	No	No	7	7
198	6x50	7x37	Shared	100	100	No	No	No	Yes	9	7
199	6x51	6x52	Shared	100	100	Yes	Yes	Yes	Yes	8	8
200	6x51	6x55	Shared	100	100	Yes	Yes	No	Yes	8	8
201	6x51	7x38	Shared	100	100	Yes	Yes	No	No	8	7
202	6x51	Lig	Shared	100	100	Yes	Yes	Yes	Yes	8	0
203	6x52	Lig	Shared	100	100	Yes	Yes	Yes	Yes	8	0
204	6x53	6x57	Shared	100	100	No	No	No	No	7	7
205	6x54	7x37	Shared	100	100	No	No	No	Yes	7	7
206	6x55	Lig	Shared	100	100	No	Yes	Yes	Yes	8	0
207	6x57	E3	Shared	100	50	No	No	Yes	No	7	5
208	6x58	E3	Shared	100	50	No	No	Yes	No	5	5
209	7x31	7x35	Shared	100	0	No	No	No	No	4	7
210	7x33	7x37	Shared	100	100	No	No	No	Yes	7	7
211	7x38	Lig	Shared	100	100	No	No	Yes	Yes	7	0
212	7x42	Lig	Shared	100	100	Yes	Yes	Yes	Yes	8	0
213	7x54	8x54	Shared	100	100	No	No	No	Yes	9	8
214	7x55	7x56	Shared	100	100	No	No	No	No	7	8
215	8x47	8x49	Shared	100	100	No	No	Yes	No	9	8
216	8x47	8x50	Shared	100	100	No	No	Yes	Yes	9	8
217	8x50	8x54	Shared	100	100	Yes	Yes	No	Yes	8	8
218	8x50	I1x50	Shared	100	100	Yes	Yes	No	No	8	9
219	3x28	E1x50	Shared	100	8.33333	Yes	Yes	Yes	Yes	7	8
220	E1x50	E2x50	Shared	100	100	Yes	Yes	No	No	8	9
221	3x49	I2x57	Shared	100	100	Yes	No	Yes	Yes	9	7
222	7x39	7x42	Shared	100	100	No	No	Yes	Yes	7	8
223	8x48	8x49	Shared	100	100	No	No	Yes	No	6	8
224	2x41	4x42	Shared	50	50	No	No	No	No	8	8
225	5x40	6x59	Shared	50	16.6667	No	No	No	No	7	7
226	1x46	2x54	Shared	50	16.6667	No	No	No	No	8	9
227	5x44	6x52	Shared	0	100	No	No	Yes	Yes	7	8
228	3x44	5x53	Shared	50	25	No	No	No	No	7	8
229	1x49	7x50	Shared	0	58.3333	No	No	No	No	9	9
230	2x53	7x46	Shared	50	100	No	No	No	No	8	9
231	8x48	8x51	Shared	50	16.6667	No	No	No	No	6	9
232	3x53	I2x57	Shared	50	100	No	No	Yes	Yes	9	7
233	4x59	4x60	Shared	50	100	No	No	No	No	8	8
234	7x36	7x40	Shared	50	100	No	No	No	No	6	8
235	3x40	5x50	Shared	0	16.6667	No	No	No	No	9	9
236	1x55	8x57	Shared	0	100	No	No	No	No	7	8
237	8x58	8x59	Shared	50	8.33333	No	No	No	No	8	6
238	1x43	2x57	Shared	0	100	No	No	No	No	7	8
239	1x52	8x57	Shared	0	66.6667	Yes	Yes	No	No	8	8
240	1x50	2x51	Shared	0	100	Yes	Yes	No	No	9	8
241	5x37	5x38	Shared	50	8.33333	No	No	No	No	5	5
242	4x59	5x39	Shared	50	100	No	No	No	Yes	8	8
243	2x46	7x49	Shared	0	100	No	No	No	Yes	9	9
244	1x45	7x47	Shared	50	66.6667	No	No	No	No	5	8
245	8x49	I1x49	Shared	50	100	Yes	No	No	No	8	7
246	1x32	2x65	Shared	0	16.6667	No	No	No	No	4	7
247	1x51	2x51	Shared	0	16.6667	No	No	No	No	6	8
248	3x37	4x56	Shared	0	100	No	No	No	No	8	8
249	8x48	8x52	Shared	50	100	No	No	No	No	6	6
250	5x52	5x56	Shared	0	16.6667	No	No	No	No	5	5
251	1x52	8x58	Shared	0	58.3333	Yes	Yes	No	No	8	8
252	4x38	4x39	Shared	0	16.6667	No	No	No	No	8	6
253	6x36	7x56	Shared	0	100	No	No	No	No	8	8
254	2x49	4x50	Shared	0	16.6667	No	No	Yes	No	8	9
255	5x64	5x68	Shared	0	0	No	No	No	No	7	8
256	5x45	5x48	Shared	50	50	No	No	No	Yes	6	7
257	1x41	1x45	Shared	0	16.6667	No	No	No	No	5	5
258	3x54	5x64	Shared	0	50	No	No	No	No	8	7
259	1x36	2x61	Shared	0	16.6667	No	No	No	No	6	8
260	1x55	1x59	Shared	0	50	No	No	No	No	7	7
261	2x37	2x39	Shared	50	58.3333	No	No	No	Yes	8	9
262	4x47	4x51	Shared	0	0	No	No	No	No	5	5
263	6x43	7x48	Shared	0	8.33333	No	No	No	No	8	7
264	7x31	7x32	Shared	0	50	No	No	No	No	4	5
265	5x49	5x50	Shared	0	8.33333	No	No	No	No	6	9
266	1x48	1x52	Shared	0	33.3333	No	No	Yes	Yes	5	8
267	5x45	5x46	Shared	0	25	No	No	No	No	6	6
268	1x40	1x43	Shared	0	8.33333	No	No	No	No	6	7
269	6x60	6x61	Shared	0	16.6667	No	No	No	No	5	3
270	3x34	4x54	Shared	0	0	No	No	No	No	7	7
271	1x54	1x58	Shared	0	8.33333	No	No	No	No	8	6
272	5x60	5x63	Shared	0	50	No	No	No	No	7	6
273	1x34	1x37	Shared	0	16.6667	No	No	No	No	3	5
274	6x41	6x42	Shared	0	0	Yes	No	No	No	7	7
275	5x55	5x59	Shared	0	0	No	No	No	No	6	4
276	4x48	4x52	Shared	0	8.33333	No	No	No	No	5	7
277	5x38	5x42	Shared	0	8.33333	No	No	No	No	5	7
278	2x40	8x50	alpha2_on	0	100	No	No	Yes	Yes	9	8
279	2x56	7x42	alpha2_on	0	100	No	No	Yes	Yes	8	8
280	3x25	E1x50	alpha2_on	0	100	No	No	Yes	Yes	9	8
281	3x34	4x57	alpha2_on	0	100	No	No	No	No	7	8
282	3x36	Lig	alpha2_on	0	100	No	No	Yes	Yes	7	0
283	3x40	6x48	alpha2_on	0	100	No	No	Yes	Yes	9	9
284	3x41	4x49	alpha2_on	0	100	Yes	No	No	No	7	8
285	3x43	7x49	alpha2_on	0	100	No	No	No	Yes	8	9
286	3x43	7x53	alpha2_on	0	100	No	No	Yes	Yes	8	9
287	3x46	3x50	alpha2_on	0	100	No	No	Yes	No	9	9
288	3x47	5x58	alpha2_on	0	100	No	No	Yes	Yes	9	9
289	3x52	3x56	alpha2_on	0	100	No	Yes	No	No	6	7
290	4x41	I2x53	alpha2_on	0	100	No	No	No	Yes	8	9
291	4x58	4x59	alpha2_on	0	100	No	No	No	No	6	8
292	6x55	E2x52	alpha2_on	0	100	No	Yes	No	No	8	7
293	5x40	E2	alpha2_on	0	100	No	No	Yes	No	7	5
294	5x55	6x41	alpha2_on	0	100	No	No	Yes	No	6	7
295	6x30	6x33	alpha2_on	0	100	No	No	No	Yes	9	8
296	6x48	7x45	alpha2_on	0	100	Yes	Yes	No	No	9	9
297	6x48	Lig	alpha2_on	0	100	Yes	Yes	Yes	Yes	9	0
298	6x49	6x50	alpha2_on	0	100	No	Yes	No	No	7	9
299	6x54	7x34	alpha2_on	0	100	No	No	No	No	7	6
300	7x38	7x42	alpha2_on	0	100	No	No	Yes	Yes	7	8
301	7x45	7x49	alpha2_on	0	100	No	No	No	Yes	9	9
302	7x52	7x53	alpha2_on	0	100	No	No	Yes	Yes	8	9
303	7x54	8x50	alpha2_on	0	100	No	No	Yes	Yes	9	8
304	2x42	3x49	alpha2_on	0	100	Yes	Yes	Yes	No	8	9
305	2x56	3x28	alpha2_on	0	100	No	No	Yes	Yes	8	7
306	3x46	7x53	alpha2_on	0	100	No	No	Yes	Yes	9	9
307	3x47	5x54	alpha2_on	0	100	No	No	No	No	9	9
308	3x50	5x58	alpha2_on	0	100	Yes	No	Yes	Yes	9	9
309	3x50	7x53	alpha2_on	0	100	Yes	No	Yes	Yes	9	9
310	3x51	5x57	alpha2_on	0	100	No	Yes	No	No	8	8
311	4x60	5x39	alpha2_on	0	100	No	No	No	Yes	8	8
312	5x43	Lig	alpha2_on	0	100	No	No	Yes	Yes	9	0
313	5x47	6x44	alpha2_on	0	100	Yes	Yes	Yes	Yes	9	9
314	5x51	6x44	alpha2_on	0	100	No	No	Yes	Yes	7	9
315	5x54	6x44	alpha2_on	0	100	No	No	Yes	Yes	9	9
316	5x58	6x37	alpha2_on	0	100	Yes	Yes	No	No	9	8
317	5x58	6x40	alpha2_on	0	100	Yes	Yes	No	No	9	8
318	5x62	6x33	alpha2_on	0	100	No	Yes	No	Yes	8	8
319	5x62	6x34	alpha2_on	0	100	No	Yes	No	No	8	8
320	5x65	6x33	alpha2_on	0	100	No	No	No	Yes	8	8
321	5x66	6x30	alpha2_on	0	100	No	No	No	No	8	9
322	2x64	7x39	alpha2_on	0	100	No	No	No	No	7	7
323	5x44	5x48	alpha2_on	0	100	No	No	No	Yes	7	7
324	5x44	6x56	alpha2_on	0	100	No	No	No	No	7	7
325	5x461	Lig	alpha2_on	0	100	No	No	Yes	Yes	8	0
326	5x69	6x29	alpha2_on	0	100	No	No	No	No	5	8
327	2x50	7x49	alpha2_on	0	100	No	Yes	No	Yes	9	9
328	5x64	5x67	alpha2_on	0	100	No	No	No	No	7	7
329	5x69	6x26	alpha2_on	0	100	No	No	No	Yes	5	5
330	6x32	7x56	alpha2_on	0	100	No	No	No	No	9	8
331	6x51	7x34	alpha2_on	0	100	Yes	Yes	No	No	8	6
332	5x38	5x39	alpha2_on	0	100	No	No	No	Yes	5	8
333	3x56	I2x53	alpha2_on	0	100	No	No	No	Yes	7	9
334	8x52	8x55	alpha2_on	0	100	No	No	No	No	6	6
335	2x46	3x42	alpha2_on	0	75	No	No	Yes	Yes	9	8
336	1x39	7x39	alpha2_on	0	50	No	No	No	No	5	7
337	2x63	E1x50	alpha2_on	0	16.6667	No	No	Yes	Yes	8	8
338	1x56	8x54	alpha2_on	0	50	No	No	No	Yes	9	8
339	E1x49	E1x50	alpha2_on	0	50	No	No	Yes	Yes	5	8
340	5x69	6x33	alpha2_on	0	50	No	No	No	Yes	5	8
341	6x45	6x49	alpha2_on	0	25	No	No	No	Yes	7	7
342	1x46	1x50	alpha2_on	0	25	No	No	Yes	Yes	8	9
343	2x42	3x45	alpha2_on	0	58.3333	Yes	Yes	No	No	8	8
344	5x62	6x37	alpha2_on	0	8.33333	No	Yes	No	No	8	8
345	2x50	3x39	alpha2_on	0	58.3333	No	Yes	No	No	9	9
346	1x54	2x47	alpha2_on	0	25	No	No	No	No	8	9
347	1x53	7x50	alpha2_on	0	50	No	No	No	No	9	9
348	3x25	3x29	alpha2_on	0	50	No	No	No	No	9	7
349	3x44	5x50	alpha2_on	0	8.33333	No	No	No	No	7	9
350	2x38	2x39	alpha2_on	0	50	No	No	No	Yes	7	9
351	3x21	3x23	alpha2_on	0	50	No	No	No	No	7	5
352	7x36	7x37	alpha2_on	0	50	No	No	No	Yes	6	7
353	1x57	2x40	alpha2_on	0	16.6667	No	No	No	No	8	9
354	3x54	I2x51	alpha2_on	0	50	No	No	No	No	8	7
355	2x66	E1x49	alpha2_on	0	16.6667	No	No	No	No	7	5
356	3x24	E1x52	alpha2_on	0	50	Yes	No	No	No	6	7
357	1x42	7x47	alpha2_on	0	8.33333	No	No	No	No	7	8
358	2x43	8x50	alpha2_on	0	25	No	No	Yes	Yes	8	8
359	2x41	4x43	alpha2_on	0	8.33333	No	No	No	No	8	6
360	5x51	5x55	alpha2_on	0	0	No	No	No	No	7	6
361	2x42	4x40	alpha2_on	0	50	Yes	Yes	No	No	8	5
362	4x40	I2x56	alpha2_on	0	50	No	No	No	No	5	6
363	7x51	7x55	alpha2_on	0	16.6667	No	No	No	No	7	7
364	5x37	6x60	alpha2_on	0	50	No	No	No	No	5	5
365	8x53	I1x50	alpha2_on	0	16.6667	No	No	No	No	8	9
366	2x48	3x45	alpha2_on	0	50	No	No	No	No	7	8
367	3x54	5x61	alpha2_on	0	8.33333	No	No	No	No	8	9
368	E1x50	E1x51	alpha2_on	0	50	Yes	Yes	Yes	No	8	5
369	1x47	2x55	alpha2_on	0	0	No	No	No	No	7	6
370	2x51	2x55	alpha2_on	0	0	No	No	No	No	8	6
371	7x30	E3	alpha2_on	0	50	No	No	Yes	No	7	5
372	3x45	4x52	alpha2_on	0	50	No	No	No	No	8	7
373	6x39	6x43	alpha2_on	0	0	No	No	No	No	7	8
374	6x28	6x32	alpha2_on	0	16.6667	No	No	No	No	5	9
375	2x62	3x31	alpha2_on	0	16.6667	No	No	No	No	7	7
376	3x26	4x61	alpha2_on	0	0	No	No	No	No	7	7
377	1x30	1x32	alpha2_on	0	25	No	No	No	No	0	4
378	5x41	5x45	alpha2_on	0	8.33333	No	No	No	No	7	6
379	3x21	3x28	alpha2_on	0	16.6667	No	No	Yes	Yes	7	7
380	7x40	7x43	alpha2_on	0	0	No	No	No	No	8	7
381	3x22	3x23	alpha2_on	0	8.33333	No	No	No	No	4	5
382	1x31	1x34	alpha2_on	0	16.6667	No	No	No	No	0	3
383	6x36	6x40	alpha2_on	0	0	No	No	No	No	8	8
384	2x39	I1x51	alpha2_on	0	8.33333	No	Yes	No	No	9	7
385	2x66	2x67	alpha2_on	0	8.33333	No	No	No	No	7	6
386	1x35	1x39	alpha2_on	0	0	No	No	No	No	6	5
387	3x26	3x27	alpha2_on	0	16.6667	No	No	No	No	7	6
388	I1x48	I1x51	alpha2_on	0	16.6667	No	No	No	No	8	7
389	4x39	4x44	alpha2_on	0	8.33333	No	No	No	No	6	3
390	3x30	4x61	alpha2_on	0	0	No	No	No	No	8	7
391	3x22	3x26	alpha2_on	0	8.33333	No	No	No	No	4	7
392	4x52	4x55	alpha2_on	0	8.33333	No	No	No	No	7	6
393	1x36	1x37	alpha2_on	0	16.6667	No	No	No	No	6	5
394	1x40	1x44	alpha2_on	0	0	No	No	No	No	6	6
395	4x58	4x62	alpha2_on	0	0	No	No	No	No	6	6
396	6x46	6x47	alpha2_on	0	8.33333	No	No	No	No	5	8
397	5x48	5x52	alpha2_on	0	8.33333	No	Yes	No	No	7	5
398	6x26	6x27	alpha2_on	0	8.33333	No	Yes	No	No	5	6
399	1x38	7x35	alpha2_on	0	8.33333	No	No	No	No	5	7
400	8x55	8x56	alpha2_on	0	0	No	No	No	No	6	7
401	I2x50	I2x51	alpha2_on	0	0	No	No	No	No	9	7
402	6x23	6x26	alpha2_on	0	8.33333	No	No	No	Yes	0	5
403	1x29	1x30	alpha2_on	0	8.33333	No	No	No	No	0	0
404	6x24	6x25	alpha2_on	0	0	No	No	No	No	0	0
405	1x32	1x33	alpha2_on	0	0	No	No	No	No	4	5
406	6x25	6x28	alpha2_on	0	0	No	No	No	No	0	5
407	4x51	4x55	alpha2_on	0	8.33333	No	No	No	No	5	6
408	5x70	6x26	alpha2_on	0	8.33333	No	No	No	Yes	0	5
409	6x22	6x24	alpha2_on	0	0	No	No	No	No	0	0
410	I2x55	I2x56	alpha2_on	0	0	No	No	No	No	6	6

Orange: nodes, hubs and links specific of alpha2_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of alpha2_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	alpha2_off Avg Int. Strength	alpha2_on Avg Int. Strength	alpha2_off Num Of Links	alpha2_on Num Of Links	ConSurf
1	NT	alpha2_off	50	0	6	0	6
2	2x45	alpha2_off	0	0	4	2	9
3	E1x51	alpha2_off	50	0	6	1	5
4	3x24	alpha2_off	50	0	4	1	6
5	3x35	alpha2_off	0	16.6667	4	3	7
6	3x41	alpha2_off	0	0	4	1	7
7	3x49	alpha2_off	50	50	4	3	9
8	3x50	alpha2_off	100	0	5	3	9
9	4x50	alpha2_off	50	0	6	3	9
10	E2	alpha2_off	100	25	10	3	5
11	6x31	alpha2_off	0	0	4	1	7
12	6x41	alpha2_off	0	0	4	2	7
13	E3	alpha2_off	50	0	7	3	5
14	8x49	alpha2_off	50	0	4	3	8
15	1x50	Shared	50	50	4	5	9
16	1x52	Shared	0	0	4	4	8
17	2x42	Shared	100	50	4	6	8
18	E1x50	Shared	50	25	5	7	8
19	3x28	Shared	100	0	6	5	7
20	3x42	Shared	100	50	4	4	8
21	I2x57	Shared	50	75	6	5	7
22	5x47	Shared	100	91.6667	4	5	9
23	5x58	Shared	50	91.6667	4	5	9
24	6x44	Shared	50	75	4	4	9
25	6x48	Shared	100	100	5	6	9
26	6x51	Shared	100	91.6667	5	5	8
27	6x52	Shared	100	83.3333	5	5	8
28	7x42	Shared	50	91.6667	5	7	8
29	7x53	Shared	50	91.6667	4	5	9
30	8x50	Shared	100	50	5	6	8
31	Lig	Shared	100	100	9	11	0
32	2x39	alpha2_on	0	50	3	4	9
33	2x50	alpha2_on	0	50	2	4	9
34	3x51	alpha2_on	50	50	3	4	8
35	3x52	alpha2_on	0	50	3	4	6
36	I2x53	alpha2_on	0	50	3	5	9
37	5x39	alpha2_on	50	50	3	4	8
38	5x48	alpha2_on	0	0	3	4	7
39	5x62	alpha2_on	0	0	2	4	8
40	6x26	alpha2_on	0	0	0	4	5
41	6x33	alpha2_on	50	50	3	4	8
42	6x49	alpha2_on	0	0	2	4	7
43	6x55	alpha2_on	50	75	3	4	8
44	7x37	alpha2_on	0	0	3	4	7
45	7x49	alpha2_on	0	66.6667	3	4	9
46	8x54	alpha2_on	0	0	3	4	8

Orange: nodes, hubs and links specific of alpha2_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of alpha2_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	alpha2_off Recurrence	alpha2_on Recurrence	alpha2_off Hub1?	alpha2_on Hub1?	alpha2_off Hub2?	alpha2_on Hub2?	ConSurf1	ConSurf2
1	7x38	Lig	alpha2_off	15.5101	1.06028	No	No	Yes	Yes	7	0
2	7x35	7x38	alpha2_off	20.3756	0	No	No	No	No	7	7
3	2x64	7x35	alpha2_off	16.5897	6.18987	No	No	No	No	7	7
4	2x64	NT	alpha2_off	15.9319	0	No	No	Yes	No	7	6
5	2x53	7x46	alpha2_off	20.3304	6.8869	No	No	No	No	8	9
6	2x53	2x56	alpha2_off	99.9297	0	No	No	No	No	8	8
7	6x33	8x47	alpha2_off	59.1183	0	No	Yes	No	No	8	9
8	6x33	6x37	alpha2_off	51.7925	0	No	Yes	No	No	8	8
9	3x46	6x37	alpha2_off	87.9896	0	No	No	No	No	9	8
10	2x42	4x46	alpha2_off	91.203	0	Yes	Yes	No	No	8	8
11	2x45	4x46	alpha2_off	93.5128	1.50206	Yes	No	No	No	9	8
12	2x45	4x50	alpha2_off	87.4523	0	Yes	No	Yes	No	9	9
13	3x35	4x50	alpha2_off	96.1338	0	Yes	No	Yes	No	7	9
14	2x53	3x35	alpha2_off	97.4392	5.4192	No	No	Yes	No	8	7
15	8x50	I1x50	alpha2_off	10.1275	6.26841	Yes	Yes	No	No	8	9
16	3x49	3x50	alpha2_off	36.182	0	Yes	No	Yes	No	9	9
17	3x50	6x37	alpha2_off	35.6045	0	Yes	No	No	No	9	8
18	7x53	8x50	alpha2_off	21.0032	0	Yes	Yes	Yes	Yes	9	8
19	E1x49	E2	alpha2_off	22.7506	0	No	No	Yes	No	5	5
20	E1x49	E1x51	alpha2_off	23.8301	0	No	No	Yes	No	5	5
21	3x28	E1x51	alpha2_off	29.9207	0	Yes	Yes	Yes	No	7	5
22	6x48	6x51	alpha2_off	24.5833	0	Yes	Yes	Yes	Yes	9	8
23	3x38	4x50	alpha2_off	16.2633	2.99921	No	No	Yes	No	8	9
24	3x38	4x53	alpha2_off	20.3756	1.50206	No	No	No	No	8	8
25	3x41	4x53	alpha2_off	18.573	0	Yes	No	No	No	7	8
26	6x44	6x48	alpha2_off	41.3236	0	Yes	Yes	Yes	Yes	9	9
27	3x43	6x41	alpha2_off	23.0568	0	No	No	Yes	No	8	7
28	5x58	6x41	alpha2_off	18.573	0	Yes	Yes	Yes	No	9	7
29	3x49	I2x53	alpha2_off	19.1856	4.86452	Yes	No	No	Yes	9	9
30	3x52	I2x53	alpha2_off	18.6634	3.29374	No	Yes	No	Yes	6	9
31	3x51	3x52	alpha2_off	15.9018	6.774	No	Yes	No	Yes	8	6
32	5x39	E2	alpha2_off	10.9008	0	No	Yes	Yes	No	8	5
33	7x49	7x53	alpha2_off	15.711	0	No	Yes	Yes	Yes	9	9
34	6x40	7x49	alpha2_off	13.0096	0	No	No	No	Yes	8	9
35	6x40	7x52	alpha2_off	11.6037	0	No	No	No	No	8	8
36	6x49	6x53	alpha2_off	18.7487	6.39113	No	Yes	No	No	7	7
37	6x53	6x57	alpha2_off	17.4483	4.87925	No	No	No	No	7	7
38	6x57	E3	alpha2_off	16.1378	3.34773	No	No	Yes	No	7	5
39	3x28	Lig	alpha2_off	44.9839	0	Yes	Yes	Yes	Yes	7	0
40	6x51	Lig	alpha2_off	21.5806	4.93815	Yes	Yes	Yes	Yes	8	0
41	6x48	6x52	alpha2_off	23.3631	5.04614	Yes	Yes	Yes	Yes	9	8
42	2x56	3x32	Shared	100	26.5659	No	No	No	No	8	8
43	3x32	Lig	Shared	91.8156	27.6163	No	No	Yes	Yes	8	0
44	1x52	8x54	Shared	15.1938	13.7934	Yes	Yes	No	Yes	8	8
45	8x50	8x54	Shared	17.9454	17.1412	Yes	Yes	No	Yes	8	8
46	8x47	8x50	Shared	48.6644	16.5276	No	No	Yes	Yes	9	8
47	2x42	3x46	Shared	88.582	50.8296	Yes	Yes	No	No	8	9
48	3x49	I2x57	Shared	13.3963	19.8655	Yes	No	Yes	Yes	9	7
49	3x43	6x44	Shared	32.3459	51.9782	No	No	Yes	Yes	8	9
50	5x47	6x52	Shared	28.5198	77.8372	Yes	Yes	Yes	Yes	9	8
51	6x52	Lig	Shared	46.3195	71.6817	Yes	Yes	Yes	Yes	8	0
52	5x47	6x49	Shared	20.0392	15.4869	Yes	Yes	No	Yes	9	7
53	8x47	8x49	Shared	12.9645	14.4954	No	No	Yes	No	9	8
54	1x39	7x39	alpha2_on	0	18.5843	No	No	No	No	5	7
55	7x39	7x42	alpha2_on	6.22113	27.2531	No	No	Yes	Yes	7	8
56	7x42	Lig	alpha2_on	7.66218	83.9436	Yes	Yes	Yes	Yes	8	0
57	6x48	Lig	alpha2_on	0	59.4051	Yes	Yes	Yes	Yes	9	0
58	6x48	7x45	alpha2_on	0	62.4534	Yes	Yes	No	No	9	9
59	7x45	7x49	alpha2_on	0	62.1588	No	No	No	Yes	9	9
60	2x50	7x49	alpha2_on	0	35.4408	No	Yes	No	Yes	9	9
61	1x50	2x50	alpha2_on	8.40028	25.6185	Yes	Yes	No	Yes	9	9
62	3x43	7x49	alpha2_on	0	62.2963	No	No	No	Yes	8	9
63	3x43	7x53	alpha2_on	0	100	No	No	Yes	Yes	8	9
64	2x43	7x53	alpha2_on	2.82185	48.6943	No	No	Yes	Yes	8	9
65	2x43	8x50	alpha2_on	0	46.8977	No	No	Yes	Yes	8	8
66	5x47	6x44	alpha2_on	0	80.2916	Yes	Yes	Yes	Yes	9	9
67	3x46	7x53	alpha2_on	0	47.9433	No	No	Yes	Yes	9	9
68	2x42	3x49	alpha2_on	0	26.6101	Yes	Yes	Yes	No	8	9
69	2x39	I2x57	alpha2_on	0.235991	15.109	No	Yes	Yes	Yes	9	7
70	2x46	7x49	alpha2_on	1.48122	14.623	No	No	No	Yes	9	9
71	2x46	3x42	alpha2_on	0	13.2044	No	No	Yes	Yes	9	8
72	2x56	7x42	alpha2_on	0	29.4129	No	No	Yes	Yes	8	8
73	2x56	3x28	alpha2_on	0	53.7012	No	No	Yes	Yes	8	7
74	2x60	7x42	alpha2_on	3.17333	29.5405	No	No	Yes	Yes	8	8
75	2x60	3x28	alpha2_on	2.68628	28.3575	No	No	Yes	Yes	8	7
76	3x28	E1x50	alpha2_on	9.31914	46.4657	Yes	Yes	Yes	Yes	7	8
77	5x54	6x44	alpha2_on	0	36.02	No	No	Yes	Yes	9	9
78	3x47	5x54	alpha2_on	0	35.1266	No	No	No	No	9	9
79	3x47	5x58	alpha2_on	0	27.2138	No	No	Yes	Yes	9	9
80	3x47	5x57	alpha2_on	2.39506	12.5761	No	No	No	No	9	8
81	3x51	5x57	alpha2_on	0	11.2655	No	Yes	No	No	8	8
82	5x43	Lig	alpha2_on	0	17.8726	No	No	Yes	Yes	9	0
83	5x39	5x43	alpha2_on	1.61679	16.454	No	Yes	No	No	8	9
84	6x55	Lig	alpha2_on	3.41936	10.1217	No	Yes	Yes	Yes	8	0
85	5x40	6x55	alpha2_on	3.0478	10.6273	No	No	No	Yes	7	8
86	5x58	6x37	alpha2_on	0	20.3269	Yes	Yes	No	No	9	8
87	5x62	6x37	alpha2_on	0	19.2617	No	Yes	No	No	8	8
88	5x62	6x33	alpha2_on	0	14.1223	No	Yes	No	Yes	8	8
89	7x52	7x53	alpha2_on	0	10.2788	No	No	Yes	Yes	8	9
90	5x58	6x40	alpha2_on	0	13.7149	Yes	Yes	No	No	9	8
91	6x36	6x40	alpha2_on	0	12.3306	No	No	No	No	8	8
92	6x36	7x56	alpha2_on	1.4762	11.2213	No	No	No	No	8	8
93	8x48	8x49	alpha2_on	5.87969	10.4015	No	No	Yes	No	6	8
94	5x47	5x48	alpha2_on	5.92991	10.3132	Yes	Yes	No	Yes	9	7
95	5x69	6x33	alpha2_on	0	10.0432	No	No	No	Yes	5	8
96	5x58	5x61	alpha2_on	7.16509	10.5782	Yes	Yes	No	No	9	9
97	E1x49	E1x50	alpha2_on	0	13.8965	No	No	Yes	Yes	5	8
98	1x39	2x61	alpha2_on	1.2854	15.6538	No	No	No	No	5	8
99	2x42	3x45	alpha2_on	0	13.7444	Yes	Yes	No	No	8	8
100	3x21	3x28	alpha2_on	0	28.1956	No	No	Yes	Yes	7	7
101	3x21	3x23	alpha2_on	0	24.6171	No	No	No	No	7	5
102	3x22	3x23	alpha2_on	0	21.0387	No	No	No	No	4	5
103	3x22	3x26	alpha2_on	0	17.4602	No	No	No	No	4	7
104	3x50	7x53	alpha2_on	0	14.7065	Yes	No	Yes	Yes	9	9
105	3x50	5x58	alpha2_on	0	18.1131	Yes	No	Yes	Yes	9	9

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
2x56	3x32	Shared	5.84	8.85083	0	1	2	1
2x57	7x42	Shared	6.005	4.23	0	0	2	1
2x59	3x28	Shared	6.705	6.53167	0	0	2	1
2x60	3x28	Shared	6.36	4.0275	0	0	2	1
2x60	7x42	Shared	6.995	4.52833	0	0	2	1
3x28	E1x51	alpha2_off	4.47	0	0	0	1	2
3x28	3x29	alpha2_off	4.69	0	0	0	1	2
3x28	Lig	alpha2_off	5.265	0	0	0	1	0
3x29	E2x52	alpha2_off	6.355	0	0	0	2	1
3x32	7x42	Shared	5.175	5.55833	1	1	1	1
3x32	Lig	Shared	27.94	9.56833	1	1	1	0
3x33	4x57	Shared	5.655	2.01917	0	0	1	2
3x33	Lig	Shared	9.785	9.66917	0	0	1	0
3x36	6x48	Shared	9.795	4.13333	0	1	1	1
3x37	4x57	alpha2_off	6.4	0	0	0	2	2
3x37	5x461	Shared	9.59	5.59333	0	0	2	1
E2x52	Lig	alpha2_off	8.42	0	0	0	1	0
5x39	5x43	Shared	9.54	8.05667	1	6	2	1
5x40	6x55	Shared	14.825	9.8525	0	0	2	1
5x47	6x52	Shared	23.045	16.9633	0	1	2	1
6x44	6x48	alpha2_off	9.665	0	0	1	2	1
6x44	7x45	alpha2_off	8.67	0	0	1	2	2
6x48	6x51	alpha2_off	5.015	0	1	1	1	1
6x48	6x52	Shared	6.01	7.685	1	1	1	1
6x48	7x41	Shared	11.965	8.20667	1	1	1	2
6x51	6x52	Shared	13.395	4.9125	1	1	1	1
6x51	6x55	Shared	6.705	8.3375	1	1	1	1
6x51	7x38	Shared	8.035	4.01667	1	1	1	1
6x51	Lig	Shared	14.97	14.0975	1	1	1	0
6x52	Lig	Shared	6.675	4.615	1	1	1	0
6x55	Lig	Shared	4.52	6.10583	1	1	1	0
7x35	7x38	alpha2_off	4.96	0	1	0	2	1
7x38	Lig	Shared	12.75	16.9	1	1	1	0
7x42	Lig	Shared	7.005	8.89667	1	1	1	0
3x28	E1x50	Shared	5.79	2.49	0	0	1	2
7x39	7x42	Shared	6.75	4.5025	0	0	2	1
5x44	6x52	Shared	4.19	3.4925	0	0	2	1
3x21	E1x50	alpha2_off	1.405	0	0	0	2	2
2x56	7x42	alpha2_on	0	3.3925	0	1	2	1
3x36	Lig	alpha2_on	0	8.96917	0	1	1	0
3x40	6x48	alpha2_on	0	10.1783	0	0	2	1
6x55	E2x52	alpha2_on	0	3.57333	1	1	1	1
6x48	7x45	alpha2_on	0	9.8875	1	1	1	2
6x48	Lig	alpha2_on	0	4.76333	1	1	1	0
7x38	7x42	alpha2_on	0	9.02333	1	1	1	1
2x56	3x28	alpha2_on	0	5.3875	0	1	2	1
5x43	Lig	alpha2_on	0	3.54833	0	0	1	0
5x47	6x44	alpha2_on	0	5.62583	0	1	2	2
5x461	Lig	alpha2_on	0	4.13	0	0	1	0
6x51	7x34	alpha2_on	0	5.35917	1	1	1	2
E1x50	E1x51	alpha2_on	0	1.67333	0	5	2	2
3x21	3x28	alpha2_on	0	1.1975	0	0	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	alpha2_off	alpha2a_off alpha2c_off
	alpha2_on	alpha2a_on alpha2b_on

Network Difference
Value	alpha2_off	alpha2_on
I_min	4.41	3.35833
Number of Linked Nodes	255	261
Number of Specific Nodes	6 (2.35%)	12 (4.60%)
Number of Shared Nodes	249 (97.65%)	249 (95.40%)
Number of Links	277	282
Number of Specific Links	128 (46.21%)	133 (47.16%)
Number of Shared Links	149 (53.79%)	149 (52.84%)
Number of Hubs	31	32
Number of Specific Hubs	14 (45.16%)	15 (46.88%)
Number of Shared Hubs	17 (54.84%)	17 (53.13%)
Average % Shared Neighbours (Jaccard)	40.25
Average % Shared Neighbours (Otsuka)	49.83
Average % Shared Neighbours (Overlap Coefficient)	59.39
Average % Shared Cliques (k3-6)	80.21
Graphlets Similarity	0.582974

Paths Difference
Value	alpha2_off	alpha2_on
Number Of Nodes in MetaPath	53	61
Specific Nodes in MetaPath	23 (43.40%)	31 (50.82%)
Shared Nodes in MetaPath	249 (97.65%)	249 (97.65%)
Number Of Links MetaPath	53	64
Specific Links in MetaPath	41 (77.36%)	52 (81.25%)
Shared Links in MetaPath	149 (53.79%)	149 (53.79%)
Number of Shortest Paths	40331	50362
Length Of Smallest Path	3	3
Average Path Length	14.2274	11.8437
Length of Longest Path	31	24
Minimum Path Strength	0.975	0.278611
Average Path Strength	7.05508	5.23707
Maximum Path Strength	19.22	12.9346
Minimum Path Correlation	0.7	0.7
Average Path Correlation	0.920515	0.89585
Maximum Path Correlation	0.99	0.99
Minimum % Of Corr. Nodes	3.7037	5
Average % Of Corr. Nodes	44.5572	36.8818
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	40.9264	45.9215
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

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