psnGPCR

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Orange: nodes, hubs and links specific of alpha2a_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of alpha2a_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	alpha2a_off Int. Strength	alpha2a_on Int. Strength	alpha2a_off Hub1?	alpha2a_on Hub1?	alpha2a_off Hub2?	alpha2a_on Hub2?	ConSurf1	ConSurf2
1	1x34	NT.V32	alpha2a_off	9.52	0	No	No	No	No	3	4
2	1x38	7x39	alpha2a_off	4.56	0	No	No	No	No	5	7
3	1x46	1x50	alpha2a_off	4.39	0	Yes	Yes	Yes	Yes	8	9
4	1x46	7x46	alpha2a_off	4.8	0	Yes	Yes	No	No	8	9
5	1x57	I1x51	alpha2a_off	6.07	0	No	No	Yes	No	8	7
6	1x60	I1x51	alpha2a_off	6.12	0	No	No	Yes	No	8	7
7	2x40	I1x51	alpha2a_off	4.2	0	No	No	Yes	No	9	7
8	8x50	I1x51	alpha2a_off	4.96	0	Yes	Yes	Yes	No	8	7
9	2x38	4x39	alpha2a_off	11.69	0	No	No	No	No	7	6
10	2x39	3x49	alpha2a_off	18.27	0	No	No	No	No	9	9
11	2x40	2x43	alpha2a_off	6.87	0	No	No	No	No	9	8
12	2x40	6x33	alpha2a_off	4.83	0	No	No	Yes	No	9	8
13	2x42	3x46	alpha2a_off	6.28	0	Yes	No	No	No	8	9
14	2x42	4x46	alpha2a_off	6.28	0	Yes	No	No	No	8	8
15	2x43	6x33	alpha2a_off	4.87	0	No	No	Yes	No	8	8
16	2x43	7x53	alpha2a_off	5.86	0	No	No	Yes	Yes	8	9
17	2x45	4x50	alpha2a_off	6.18	0	Yes	Yes	Yes	No	9	9
18	2x53	2x56	alpha2a_off	8.02	0	No	No	No	No	8	8
19	2x59	3x24	alpha2a_off	29.06	0	No	No	No	No	7	6
20	2x60	3x28	alpha2a_off	7.63	0	No	No	Yes	No	8	7
21	2x63	E1x49	alpha2a_off	13.96	0	No	No	Yes	No	8	5
22	2x63	E1x51	alpha2a_off	24.42	0	No	No	Yes	No	8	5
23	2x64	7x31	alpha2a_off	11.63	0	No	No	No	No	7	4
24	E1x49	E1x51	alpha2a_off	6.95	0	Yes	No	Yes	No	5	5
25	E1x49	E2.R202	alpha2a_off	5.14	0	Yes	No	No	No	5	5
26	7x31	E1x49	alpha2a_off	5.14	0	No	No	Yes	No	4	5
27	3x24	E1x51	alpha2a_off	16.4	0	No	No	Yes	No	6	5
28	3x25	E1x51	alpha2a_off	12.1	0	No	No	Yes	No	9	5
29	3x28	E1x51	alpha2a_off	8.94	0	Yes	No	Yes	No	7	5
30	E1x51	E2x50	alpha2a_off	20.16	0	Yes	No	No	Yes	5	9
31	3x22	E2.P198	alpha2a_off	5.02	0	No	No	No	No	4	5
32	3x25	E2.I187	alpha2a_off	4.91	0	No	No	Yes	No	9	6
33	3x26	E2.S186	alpha2a_off	8.62	0	No	No	No	No	7	6
34	3x28	3x29	alpha2a_off	4.69	0	Yes	No	No	No	7	7
35	3x28	Lig	alpha2a_off	6.48	0	Yes	No	Yes	Yes	7	0
36	3x29	E2.I187	alpha2a_off	4.28	0	No	No	Yes	No	7	6
37	3x29	E2x52	alpha2a_off	8.56	0	No	No	No	No	7	7
38	3x34	4x50	alpha2a_off	5.69	0	No	No	Yes	No	7	9
39	3x37	4x57	alpha2a_off	6.4	0	Yes	Yes	No	No	8	8
40	3x38	3x42	alpha2a_off	8.37	0	No	No	Yes	No	8	8
41	3x41	5x50	alpha2a_off	18.92	0	No	No	No	No	7	9
42	3x43	5x54	alpha2a_off	4.24	0	Yes	No	Yes	No	8	9
43	3x43	6x41	alpha2a_off	5.71	0	Yes	No	No	No	8	7
44	3x49	3x50	alpha2a_off	7.15	0	No	No	Yes	No	9	9
45	3x50	6x33	alpha2a_off	6.41	0	Yes	No	Yes	No	9	8
46	3x50	6x34	alpha2a_off	9.06	0	Yes	No	No	No	9	8
47	3x50	6x37	alpha2a_off	6.07	0	Yes	No	No	No	9	8
48	3x51	3x52	alpha2a_off	4.82	0	No	No	No	No	8	6
49	3x53	6x30	alpha2a_off	4.31	0	No	No	No	No	9	9
50	3x56	I2x52	alpha2a_off	7.65	0	No	No	No	No	7	6
51	4x43	4x46	alpha2a_off	8.72	0	No	No	No	No	6	8
52	4x43	4x47	alpha2a_off	8.72	0	No	No	No	No	6	5
53	4x59	5x39	alpha2a_off	6.95	0	No	No	Yes	No	8	8
54	4x62	E2.N206	alpha2a_off	5.66	0	No	No	No	No	6	7
55	E2.R202	E2x51	alpha2a_off	8.14	0	No	No	No	No	5	4
56	E2x52	Lig	alpha2a_off	10.14	0	No	No	Yes	Yes	7	0
57	6x55	E2.D207	alpha2a_off	6.9	0	No	Yes	No	No	8	5
58	5x54	6x41	alpha2a_off	10.2	0	Yes	No	No	No	9	7
59	5x58	5x61	alpha2a_off	9.67	0	No	Yes	No	No	9	9
60	5x58	6x38	alpha2a_off	6.67	0	No	Yes	No	No	9	7
61	5x60	5x64	alpha2a_off	7.52	0	No	No	No	No	7	7
62	6x28	6x31	alpha2a_off	6.99	0	No	No	Yes	No	5	7
63	6x29	8x49	alpha2a_off	5.96	0	No	No	No	No	8	8
64	6x33	6x37	alpha2a_off	9.74	0	Yes	No	No	No	8	8
65	6x40	7x49	alpha2a_off	5.91	0	No	No	No	Yes	8	9
66	6x40	7x52	alpha2a_off	6.14	0	No	No	No	No	8	8
67	6x44	6x48	alpha2a_off	9.02	0	No	Yes	Yes	Yes	9	9
68	6x44	7x45	alpha2a_off	6.04	0	No	Yes	No	No	9	9
69	6x48	6x51	alpha2a_off	7.02	0	Yes	Yes	Yes	Yes	9	8
70	6x49	6x50	alpha2a_off	4.33	0	No	No	No	No	7	9
71	6x57	E3.C416	alpha2a_off	9.52	0	No	No	No	No	7	8
72	7x34	E3.V418	alpha2a_off	6.55	0	No	No	No	No	6	6
73	7x30	7x33	alpha2a_off	9.85	0	No	No	No	No	7	7
74	7x31	7x35	alpha2a_off	30.94	0	No	No	No	No	4	7
75	7x35	7x38	alpha2a_off	4.96	0	No	No	No	No	7	7
76	7x36	7x39	alpha2a_off	6.01	0	No	No	No	No	6	7
77	7x49	7x50	alpha2a_off	4.89	0	No	Yes	No	No	9	9
78	7x53	8x50	alpha2a_off	13.41	0	Yes	Yes	Yes	Yes	9	8
79	8x50	8x54	alpha2a_off	6.43	0	Yes	Yes	Yes	Yes	8	8
80	8x56	8x60	alpha2a_off	4.95	0	No	No	No	No	7	7
81	8x59	8x60	alpha2a_off	4.18	0	No	No	No	No	6	7
82	2x46	3x43	alpha2a_off	4.15	0	No	No	Yes	No	9	8
83	E2.E188	E2.I187	alpha2a_off	4.1	0	No	No	Yes	No	6	6
84	1x49	7x50	alpha2a_off	4.06	0	No	No	No	No	9	9
85	1x53	8x54	alpha2a_off	3.93	0	No	No	Yes	Yes	9	8
86	3x41	3x44	alpha2a_off	3.92	0	No	No	No	No	7	7
87	5x48	6x56	alpha2a_off	3.89	0	Yes	Yes	No	No	7	7
88	7x54	8x51	alpha2a_off	3.88	0	No	No	No	No	9	9
89	3x40	5x50	alpha2a_off	3.74	0	No	No	No	No	9	9
90	2x57	7x42	alpha2a_off	3.63	0	No	No	Yes	Yes	8	8
91	5x51	6x45	alpha2a_off	3.42	0	No	No	No	No	7	7
92	4x60	4x62	alpha2a_off	3.39	0	No	No	No	No	8	6
93	2x45	2x48	alpha2a_off	3.26	0	Yes	Yes	No	No	9	7
94	2x62	2x66	alpha2a_off	3.22	0	No	No	No	No	7	7
95	5x65	6x31	alpha2a_off	3.21	0	No	No	Yes	No	8	7
96	3x47	5x54	alpha2a_off	3.07	0	No	No	Yes	No	9	9
97	5x57	5x61	alpha2a_off	3.07	0	No	Yes	No	No	8	9
98	1x55	1x59	alpha2a_off	3.04	0	No	No	No	No	7	7
99	2x46	3x39	alpha2a_off	3	0	No	No	No	No	9	9
100	6x31	6x34	alpha2a_off	3	0	Yes	No	No	No	7	8
101	2x61	2x65	alpha2a_off	2.98	0	No	No	Yes	No	8	7
102	1x34	1x35	alpha2a_off	2.95	0	No	No	No	No	3	6
103	1x52	8x57	alpha2a_off	2.85	0	No	No	No	No	8	8
104	2x67	E1x50	alpha2a_off	2.81	0	No	No	Yes	Yes	6	8
105	4x60	5x39	alpha2a_off	2.78	0	No	No	Yes	No	8	8
106	1x56	8x50	alpha2a_off	2.77	0	No	No	Yes	Yes	9	8
107	2x49	4x50	alpha2a_off	2.59	0	No	No	Yes	No	8	9
108	3x53	I2x53	alpha2a_off	2.54	0	No	No	No	No	9	9
109	6x36	7x53	alpha2a_off	2.52	0	No	No	Yes	Yes	8	9
110	7x52	7x56	alpha2a_off	2.51	0	No	No	No	No	8	8
111	1x48	8x58	alpha2a_off	2.44	0	No	No	No	No	5	8
112	6x27	6x32	alpha2a_off	2.34	0	No	No	No	No	6	9
113	2x66	E1x50	alpha2a_off	2.33	0	No	No	Yes	Yes	7	8
114	E1x50	E2.E200	alpha2a_off	2.18	0	Yes	Yes	No	No	8	3
115	2x37	2x38	alpha2a_off	1.87	0	No	No	No	No	8	7
116	1x56	8x53	alpha2a_off	1.79	0	No	No	No	No	9	8
117	4x56	5x46	alpha2a_off	1.76	0	No	No	No	No	8	6
118	6x60	E3.C416	alpha2a_off	1.71	0	No	No	No	No	5	8
119	1x47	2x54	alpha2a_off	1.7	0	No	No	No	No	7	9
120	3x45	4x49	alpha2a_off	1.7	0	No	Yes	No	No	8	8
121	6x58	E3.V418	alpha2a_off	1.59	0	No	No	No	No	5	6
122	E2.E200	E2.P201	alpha2a_off	1.57	0	No	No	No	No	3	3
123	3x53	3x54	alpha2a_off	1.55	0	No	No	No	No	9	8
124	4x52	4x53	alpha2a_off	1.55	0	No	No	Yes	Yes	7	8
125	E2.I187	E2.S186	alpha2a_off	1.55	0	Yes	No	No	No	6	6
126	5x55	5x59	alpha2a_off	1.54	0	No	No	No	No	6	4
127	4x48	4x52	alpha2a_off	1.52	0	No	No	No	No	5	7
128	5x66	5x69	alpha2a_off	1.5	0	No	No	No	No	8	5
129	2x65	NT.L30	alpha2a_off	1.49	0	Yes	No	No	No	7	8
130	1x33	1x36	alpha2a_off	1.49	0	No	No	No	No	5	6
131	5x41	5x45	alpha2a_off	1.47	0	No	No	No	No	7	6
132	5x54	5x55	alpha2a_off	1.46	0	Yes	No	No	No	9	6
133	8x55	8x56	alpha2a_off	1.44	0	No	No	No	No	6	7
134	5x52	5x53	alpha2a_off	1.43	0	No	No	No	No	5	8
135	1x35	NT.L30	alpha2a_off	1.38	0	No	No	No	No	6	8
136	I1x48	I1x49	alpha2a_off	1.38	0	No	No	No	No	8	7
137	2x551	3x31	alpha2a_off	1.38	0	No	No	No	No	7	7
138	I2x54	I2x55	alpha2a_off	1.37	0	No	No	No	No	7	6
139	4x38	4x41	alpha2a_off	1.29	0	No	No	No	No	8	8
140	8x52	8x56	alpha2a_off	1.24	0	No	No	No	No	6	7
141	4x58	4x61	alpha2a_off	1.22	0	No	No	No	No	6	7
142	I1x48	I1x50	alpha2a_off	1.21	0	No	No	No	Yes	8	9
143	1x39	2x61	Shared	4.73	3.15167	No	No	No	No	5	8
144	1x43	2x58	Shared	6.71	1.95667	No	No	No	No	7	9
145	1x46	2x54	Shared	5.03	2.23833	Yes	Yes	No	No	8	9
146	1x46	7x47	Shared	4.8	4.26333	Yes	Yes	No	No	8	8
147	1x50	2x47	Shared	4.69	2.605	Yes	Yes	No	No	9	9
148	1x50	2x50	Shared	12.12	9.2	Yes	Yes	No	No	9	9
149	1x50	2x51	Shared	4.25	3.54	Yes	Yes	No	No	9	8
150	1x50	7x50	Shared	9.77	5.16	Yes	Yes	No	No	9	9
151	1x52	8x54	Shared	9.74	8.12	No	No	Yes	Yes	8	8
152	1x57	2x44	Shared	4.81	3.20667	No	No	No	No	8	7
153	1x60	I1x50	Shared	4.5	4.755	No	No	No	Yes	8	9
154	2x38	I2x57	Shared	4.32	1.92	No	No	No	Yes	7	7
155	2x39	I2x57	Shared	12.85	7.78667	No	No	No	Yes	9	7
156	2x41	4x42	Shared	4.28	3.03	No	No	No	No	8	8
157	2x42	4x42	Shared	7.54	5.65167	Yes	No	No	No	8	8
158	2x42	4x45	Shared	5.02	4.395	Yes	No	No	No	8	7
159	2x45	3x42	Shared	9.76	6.975	Yes	Yes	Yes	No	9	8
160	2x45	4x46	Shared	4.64	3.095	Yes	Yes	No	No	9	8
161	2x50	7x46	Shared	8.83	4.41833	No	No	No	No	9	9
162	2x52	3x35	Shared	10.96	7.91667	No	No	No	Yes	8	7
163	2x53	3x35	Shared	6.55	4.80667	No	No	No	Yes	8	7
164	2x53	7x46	Shared	4.85	3.55667	No	No	No	No	8	9
165	2x55	2x551	Shared	4.42	2.45667	No	No	No	No	6	7
166	2x56	3x32	Shared	5.84	5.11167	No	No	No	No	8	8
167	2x57	2x58	Shared	5.08	3.24167	No	No	No	No	8	9
168	2x59	3x28	Shared	7.22	4.81333	No	No	Yes	No	7	7
169	2x60	7x42	Shared	6.36	3.96667	No	No	Yes	Yes	8	8
170	2x64	7x35	Shared	13.5	7.425	No	No	No	No	7	7
171	3x25	E2x50	Shared	7.28	4.24667	No	No	No	Yes	9	9
172	3x28	E2x50	Shared	5.38	2.875	Yes	No	No	Yes	7	9
173	3x31	3x35	Shared	7.31	4.06	No	No	No	Yes	7	7
174	3x32	7x42	Shared	4.6	4.21667	No	No	Yes	Yes	8	8
175	3x32	Lig	Shared	26.78	9.28667	No	No	Yes	Yes	8	0
176	3x33	4x57	Shared	6.46	4.03833	No	No	No	No	8	8
177	3x33	Lig	Shared	8.23	9.71833	No	No	Yes	Yes	8	0
178	3x34	4x57	Shared	4.5	4.755	No	No	No	No	7	8
179	3x36	6x48	Shared	10.45	3.04667	No	No	Yes	Yes	7	9
180	3x37	4x53	Shared	4.8	2.62667	Yes	Yes	Yes	Yes	8	8
181	3x37	5x461	Shared	9.59	3.19667	Yes	Yes	No	No	8	8
182	3x38	4x50	Shared	17.3	6.59	No	No	Yes	No	8	9
183	3x38	4x53	Shared	4.89	2.71667	No	No	Yes	Yes	8	8
184	3x42	4x49	Shared	8.3	4.15167	Yes	No	No	No	8	8
185	3x42	4x50	Shared	9.52	3.35	Yes	No	Yes	No	8	9
186	3x43	6x44	Shared	4.87	3.07	Yes	No	No	Yes	8	9
187	3x47	5x57	Shared	8.08	3.23167	No	No	No	Yes	9	8
188	3x49	I2x53	Shared	12.64	5.74833	No	No	No	No	9	9
189	3x51	3x55	Shared	8.74	10.9783	No	No	No	No	8	7
190	3x51	5x60	Shared	8.23	3.08667	No	No	No	No	8	7
191	3x52	I2x53	Shared	11.58	7.87833	No	No	No	No	6	9
192	3x55	3x56	Shared	7.09	1.41667	No	No	No	No	7	7
193	I2x54	I2x57	Shared	9.64	0.403333	No	No	No	Yes	7	7
194	4x41	I2x56	Shared	17.33	2.89	No	No	No	Yes	8	6
195	4x58	4x59	Shared	5.78	5.77833	No	No	No	No	6	8
196	6x55	E2x52	Shared	4.84	3.62667	No	Yes	No	No	8	7
197	5x36	5x39	Shared	4.51	3.75667	No	No	Yes	No	6	8
198	5x37	5x38	Shared	6.96	2.32	No	No	No	No	5	5
199	5x39	5x43	Shared	6.36	4.66333	Yes	No	No	No	8	9
200	5x40	6x55	Shared	15.14	3.995	No	No	No	Yes	7	8
201	5x44	6x52	Shared	4.19	3.025	No	No	Yes	Yes	7	8
202	5x45	5x48	Shared	5.02	3.35	No	No	Yes	Yes	6	7
203	5x47	5x48	Shared	7.5	5.36	Yes	Yes	Yes	Yes	9	7
204	5x47	5x51	Shared	11.17	5.82	Yes	Yes	No	No	9	7
205	5x47	6x49	Shared	4.29	4.645	Yes	Yes	No	No	9	7
206	5x47	6x52	Shared	23.58	16.7767	Yes	Yes	Yes	Yes	9	8
207	5x48	6x52	Shared	4.29	4.10833	Yes	Yes	Yes	Yes	7	8
208	5x58	6x37	Shared	4.69	4.885	No	Yes	No	No	9	8
209	5x62	5x66	Shared	19.11	4.77667	No	No	No	No	8	8
210	6x27	6x31	Shared	20.34	2.93833	No	No	Yes	No	6	7
211	6x35	6x39	Shared	5.24	5.46167	No	No	No	No	7	7
212	6x43	7x52	Shared	4.61	5.375	No	No	No	No	8	8
213	6x47	7x45	Shared	9.45	7.87333	No	No	No	No	8	9
214	6x48	6x52	Shared	6.01	7.35	Yes	Yes	Yes	Yes	9	8
215	6x48	7x41	Shared	12.67	7.97333	Yes	Yes	No	No	9	8
216	6x49	6x53	Shared	8.57	5.895	No	No	No	No	7	7
217	6x50	7x37	Shared	11.56	10.595	No	No	Yes	Yes	9	7
218	6x51	6x52	Shared	13.93	3.395	Yes	Yes	Yes	Yes	8	8
219	6x51	7x38	Shared	8.57	5.89333	Yes	Yes	No	No	8	7
220	6x51	Lig	Shared	17.3	10.505	Yes	Yes	Yes	Yes	8	0
221	6x52	Lig	Shared	5.77	3.33	Yes	Yes	Yes	Yes	8	0
222	6x54	7x34	Shared	5.19	5.62167	No	No	No	No	7	6
223	6x54	7x37	Shared	9.08	6.485	No	No	Yes	Yes	7	7
224	7x38	Lig	Shared	8.65	16.11	No	No	Yes	Yes	7	0
225	7x42	Lig	Shared	8.33	9.28333	Yes	Yes	Yes	Yes	8	0
226	7x49	7x53	Shared	5.81	3.685	No	Yes	Yes	Yes	9	9
227	7x54	8x54	Shared	5.19	8	No	No	Yes	Yes	9	8
228	7x55	7x56	Shared	8.79	8.37333	No	No	No	No	7	8
229	8x47	8x50	Shared	7.25	8.25667	No	No	Yes	Yes	9	8
230	8x48	8x51	Shared	4.51	2.445	No	No	No	No	6	9
231	8x47	8x49	Shared	4.04	4.04167	No	No	No	No	9	8
232	3x41	4x53	Shared	3.71	3.07333	No	No	Yes	Yes	7	8
233	1x48	1x52	Shared	3.65	2.23167	No	No	No	No	5	8
234	6x53	6x57	Shared	3.65	6.49667	No	No	No	No	7	7
235	7x33	7x37	Shared	3.65	4.06	No	No	Yes	Yes	7	7
236	1x40	1x43	Shared	3.49	1.74833	No	No	No	No	6	7
237	5x40	6x59	Shared	3.39	2.26333	No	No	No	No	7	7
238	3x44	5x53	Shared	3.27	1.90833	No	No	No	No	7	8
239	1x54	2x47	Shared	3.25	1.895	No	No	No	No	8	9
240	1x32	2x65	Shared	3.17	1.58667	No	No	Yes	No	4	7
241	1x42	7x43	Shared	3.17	1.32333	No	No	No	No	7	7
242	1x51	2x51	Shared	3.07	1.28	No	No	No	No	6	8
243	3x37	4x56	Shared	3.04	2.515	Yes	Yes	No	No	8	8
244	5x37	6x60	Shared	3.04	3.54167	No	No	No	No	5	5
245	1x42	7x47	Shared	3	1.50167	No	No	No	No	7	8
246	1x36	2x61	Shared	2.98	1.98667	No	No	No	No	6	8
247	1x55	8x57	Shared	2.94	3.16667	No	No	No	No	7	8
248	1x41	1x45	Shared	2.77	1.84667	No	No	No	No	5	5
249	1x56	8x54	Shared	2.77	3.17	No	No	Yes	Yes	9	8
250	5x52	5x56	Shared	2.77	1.845	No	No	No	No	5	5
251	6x39	7x56	Shared	2.62	1.74667	No	No	No	No	7	8
252	5x64	5x68	Shared	2.51	0.625	No	No	No	No	7	8
253	5x43	Lig	Shared	2.37	4.67667	No	No	Yes	Yes	9	0
254	5x60	5x63	Shared	2.34	3.505	No	No	No	No	7	6
255	3x48	3x52	Shared	2.28	3.22833	No	No	No	No	7	6
256	7x37	7x40	Shared	2.14	0.893333	Yes	Yes	No	No	7	8
257	3x24	E1x52	Shared	2	4.51	No	No	No	No	6	7
258	5x49	5x50	Shared	1.87	1.87	No	No	No	No	6	9
259	5x45	5x46	Shared	1.76	2.05833	No	No	No	No	6	6
260	6x41	6x42	Shared	1.76	1.76	No	No	No	No	7	7
261	4x38	4x39	Shared	1.75	2.27667	No	No	No	No	8	6
262	3x34	4x54	Shared	1.58	1.05333	No	No	No	No	7	7
263	4x47	4x51	Shared	1.54	0.77	No	No	No	No	5	5
264	2x65	2x66	Shared	1.52	1.01333	Yes	No	No	No	7	7
265	1x45	7x47	Shared	1.5	2.25	No	No	No	No	5	8
266	6x43	7x48	Shared	1.49	1.98667	No	No	No	No	8	7
267	4x38	4x40	Shared	1.29	1.72333	No	No	No	Yes	8	5
268	E1x50	E1x52	Shared	1	4.20833	Yes	Yes	No	No	8	7
269	1x53	7x50	alpha2a_on	0	3.35333	No	No	No	No	9	9
270	2x40	I1x50	alpha2a_on	0	3.205	No	No	No	Yes	9	9
271	8x50	I1x50	alpha2a_on	0	9.74333	Yes	Yes	No	Yes	8	9
272	2x46	7x49	alpha2a_on	0	2.975	No	No	No	Yes	9	9
273	2x56	7x42	alpha2a_on	0	3.155	No	No	Yes	Yes	8	8
274	E1x50	E2x50	alpha2a_on	0	5.00667	Yes	Yes	No	Yes	8	9
275	3x25	3x29	alpha2a_on	0	3.53333	No	No	No	No	9	7
276	3x36	Lig	alpha2a_on	0	11.5383	No	No	Yes	Yes	7	0
277	3x40	6x48	alpha2a_on	0	7.43667	No	No	Yes	Yes	9	9
278	3x43	7x49	alpha2a_on	0	4.805	Yes	No	No	Yes	8	9
279	3x43	7x53	alpha2a_on	0	6.44833	Yes	No	Yes	Yes	8	9
280	3x47	5x58	alpha2a_on	0	4.14333	No	No	No	Yes	9	9
281	3x49	I2x57	alpha2a_on	0	4.96333	No	No	No	Yes	9	7
282	3x53	I2x57	alpha2a_on	0	3.29667	No	No	No	Yes	9	7
283	I2x53	I2x57	alpha2a_on	0	8.06	No	No	No	Yes	9	7
284	5x36	E2.N206	alpha2a_on	0	7.92833	No	No	No	No	6	7
285	5x55	6x41	alpha2a_on	0	2.94167	No	No	No	No	6	7
286	6x30	6x33	alpha2a_on	0	6.22	No	No	Yes	No	9	8
287	6x36	7x56	alpha2a_on	0	15.73	No	No	No	No	8	8
288	6x40	7x53	alpha2a_on	0	3.155	No	No	Yes	Yes	8	9
289	6x48	7x45	alpha2a_on	0	9.605	Yes	Yes	No	No	9	9
290	6x48	Lig	alpha2a_on	0	4.01667	Yes	Yes	Yes	Yes	9	0
291	6x51	6x55	alpha2a_on	0	8.425	Yes	Yes	No	Yes	8	8
292	6x55	Lig	alpha2a_on	0	5.59167	No	Yes	Yes	Yes	8	0
293	6x57	E3.S417	alpha2a_on	0	3.00167	No	No	No	No	7	1
294	6x58	7x30	alpha2a_on	0	3.20667	No	No	No	No	5	7
295	7x33	7x36	alpha2a_on	0	3.24667	No	No	No	No	7	6
296	7x35	7x39	alpha2a_on	0	3.67333	No	No	No	No	7	7
297	7x38	7x42	alpha2a_on	0	8.76667	No	No	Yes	Yes	7	8
298	7x39	7x42	alpha2a_on	0	3.215	No	No	Yes	Yes	7	8
299	7x45	7x49	alpha2a_on	0	3.85833	No	No	No	Yes	9	9
300	7x52	7x53	alpha2a_on	0	3.42667	No	No	Yes	Yes	8	9
301	7x54	8x50	alpha2a_on	0	10.81	No	No	Yes	Yes	9	8
302	8x48	8x52	alpha2a_on	0	5.64167	No	No	No	No	6	6
303	3x46	7x53	alpha2a_on	0	5.34833	No	No	Yes	Yes	9	9
304	3x50	5x58	alpha2a_on	0	5.29667	Yes	No	No	Yes	9	9
305	3x50	7x53	alpha2a_on	0	2.91333	Yes	No	Yes	Yes	9	9
306	3x51	5x57	alpha2a_on	0	3.23	No	No	No	Yes	8	8
307	5x39	E2.N206	alpha2a_on	0	5.62	Yes	No	No	No	8	7
308	5x47	6x44	alpha2a_on	0	3.75167	Yes	Yes	No	Yes	9	9
309	5x51	6x44	alpha2a_on	0	5.35333	No	No	No	Yes	7	9
310	5x54	6x44	alpha2a_on	0	5.39	Yes	No	No	Yes	9	9
311	5x58	6x40	alpha2a_on	0	3.57833	No	Yes	No	No	9	8
312	5x62	6x34	alpha2a_on	0	4.78667	No	No	No	No	8	8
313	5x65	6x33	alpha2a_on	0	3.69667	No	No	Yes	No	8	8
314	5x66	6x30	alpha2a_on	0	5.4	No	No	No	No	8	9
315	E1x49	E1x50	alpha2a_on	0	5.74333	Yes	No	Yes	Yes	5	8
316	E1x50	E2.R202	alpha2a_on	0	3.165	Yes	Yes	No	No	8	5
317	5x44	6x56	alpha2a_on	0	3.38	No	No	No	No	7	7
318	7x31	7x32	alpha2a_on	0	3.01833	No	No	No	No	4	5
319	E1x50	E1x51	alpha2a_on	0	3.34667	Yes	Yes	Yes	No	8	5
320	6x51	7x34	alpha2a_on	0	4.28833	Yes	Yes	No	No	8	6
321	1x53	2x53	alpha2a_on	0	4.26333	No	No	No	No	9	8
322	2x38	I1x50	alpha2a_on	0	3.00333	No	No	No	Yes	7	9
323	2x38	8x50	alpha2a_on	0	2.84167	No	No	Yes	Yes	7	8
324	2x42	4x40	alpha2a_on	0	4.08833	Yes	No	No	Yes	8	5
325	2x48	3x45	alpha2a_on	0	3.48667	No	No	No	Yes	7	8
326	2x55	3x38	alpha2a_on	0	2.84167	No	No	No	No	6	8
327	3x21	3x23	alpha2a_on	0	4.845	No	No	No	No	7	5
328	3x35	Lig	alpha2a_on	0	5.17333	No	Yes	Yes	Yes	7	0
329	3x45	4x52	alpha2a_on	0	2.99833	No	Yes	No	No	8	7
330	3x45	4x53	alpha2a_on	0	2.99833	No	Yes	Yes	Yes	8	8
331	3x52	4x40	alpha2a_on	0	2.97833	No	No	No	Yes	6	5
332	3x54	I2x51	alpha2a_on	0	4.57833	No	No	No	No	8	7
333	3x55	I2x56	alpha2a_on	0	3.21667	No	No	No	Yes	7	6
334	4x40	I2x56	alpha2a_on	0	3.94333	No	Yes	No	Yes	5	6
335	6x45	6x49	alpha2a_on	0	2.83833	No	No	No	No	7	7
336	2x63	E1x50	alpha2a_on	0	2.825	No	No	Yes	Yes	8	8
337	6x28	6x32	alpha2a_on	0	2.81333	No	No	No	No	5	9
338	3x37	4x60	alpha2a_on	0	2.75333	Yes	Yes	No	No	8	8
339	2x62	3x31	alpha2a_on	0	2.75167	No	No	No	No	7	7
340	2x45	4x45	alpha2a_on	0	2.72	Yes	Yes	No	No	9	7
341	2x59	3x35	alpha2a_on	0	2.67667	No	No	No	Yes	7	7
342	1x46	2x60	alpha2a_on	0	2.67167	Yes	Yes	No	No	8	8
343	E2.F181	E2x50	alpha2a_on	0	2.64833	No	No	No	Yes	0	9
344	1x55	8x54	alpha2a_on	0	2.64	No	No	Yes	Yes	7	8
345	7x31	E3.V418	alpha2a_on	0	2.61667	No	No	No	No	4	6
346	5x36	5x38	alpha2a_on	0	2.55667	No	No	No	No	6	5
347	3x54	5x57	alpha2a_on	0	2.52333	No	No	No	Yes	8	8
348	1x30	1x32	alpha2a_on	0	2.46667	No	No	No	No	0	4
349	3x21	3x28	alpha2a_on	0	2.395	No	No	Yes	No	7	7
350	3x39	Lig	alpha2a_on	0	2.325	No	No	Yes	Yes	9	0
351	8x48	8x49	alpha2a_on	0	2.31	No	No	No	No	6	8
352	7x51	7x55	alpha2a_on	0	2.305	No	No	No	No	7	7
353	5x58	6x41	alpha2a_on	0	2.21667	No	Yes	No	No	9	7
354	2x49	3x45	alpha2a_on	0	2.14333	No	No	No	Yes	8	8
355	6x58	E3.S417	alpha2a_on	0	2.13333	No	No	No	No	5	1
356	5x69	6x30	alpha2a_on	0	2.11667	No	No	No	No	5	9
357	I2x51	I2x52	alpha2a_on	0	2.06667	No	No	No	No	7	6
358	7x30	E3.V418	alpha2a_on	0	2.06333	No	No	No	No	7	6
359	2x43	8x50	alpha2a_on	0	2.03	No	No	Yes	Yes	8	8
360	3x21	E2.P201	alpha2a_on	0	2.02667	No	No	No	No	7	3
361	5x63	5x67	alpha2a_on	0	1.98167	No	No	No	No	6	7
362	5x48	5x49	alpha2a_on	0	1.965	Yes	Yes	No	No	7	6
363	1x58	2x44	alpha2a_on	0	1.965	No	No	No	No	6	7
364	E2.D207	E2x51	alpha2a_on	0	1.94833	No	No	No	No	5	4
365	3x47	5x59	alpha2a_on	0	1.90833	No	No	No	No	9	4
366	8x53	I1x50	alpha2a_on	0	1.90667	No	No	No	Yes	8	9
367	2x54	2x57	alpha2a_on	0	1.895	No	No	No	No	9	8
368	3x22	3x23	alpha2a_on	0	1.89	No	No	No	No	4	5
369	2x45	4x48	alpha2a_on	0	1.88333	Yes	Yes	No	No	9	5
370	E1x52	E2.E200	alpha2a_on	0	1.87	No	No	No	No	7	3
371	1x31	1x34	alpha2a_on	0	1.86667	No	No	No	No	0	3
372	2x39	I1x51	alpha2a_on	0	1.85667	No	No	Yes	No	9	7
373	8x58	8x59	alpha2a_on	0	1.85167	No	No	No	No	8	6
374	6x60	6x61	alpha2a_on	0	1.84	No	No	No	No	5	3
375	3x54	5x61	alpha2a_on	0	1.83	No	No	No	No	8	9
376	2x37	2x40	alpha2a_on	0	1.82333	No	No	No	No	8	9
377	8x49	I1x49	alpha2a_on	0	1.80167	No	No	No	No	8	7
378	1x48	1x49	alpha2a_on	0	1.75833	No	No	No	No	5	9
379	5x62	6x37	alpha2a_on	0	1.75667	No	No	No	No	8	8
380	2x66	2x67	alpha2a_on	0	1.75	No	No	No	No	7	6
381	5x53	5x57	alpha2a_on	0	1.745	No	No	No	Yes	8	8
382	1x39	2x64	alpha2a_on	0	1.73833	No	No	No	No	5	7
383	3x26	3x27	alpha2a_on	0	1.72833	No	No	No	No	7	6
384	1x57	2x40	alpha2a_on	0	1.725	No	No	No	No	8	9
385	5x41	6x55	alpha2a_on	0	1.68167	No	No	No	Yes	7	8
386	I1x48	I1x51	alpha2a_on	0	1.65167	No	No	Yes	No	8	7
387	4x39	4x44	alpha2a_on	0	1.65	No	No	No	No	6	3
388	2x41	4x43	alpha2a_on	0	1.645	No	No	No	No	8	6
389	E2x51	E2x52	alpha2a_on	0	1.59333	No	No	No	No	4	7
390	3x22	3x26	alpha2a_on	0	1.575	No	No	No	No	4	7
391	3x27	3x30	alpha2a_on	0	1.565	No	No	No	No	6	8
392	5x61	5x64	alpha2a_on	0	1.55833	No	No	No	No	9	7
393	4x52	4x55	alpha2a_on	0	1.535	No	No	No	No	7	6
394	6x39	7x52	alpha2a_on	0	1.535	No	No	No	No	7	8
395	1x36	1x37	alpha2a_on	0	1.47333	No	No	No	No	6	5
396	6x46	6x47	alpha2a_on	0	1.425	No	No	No	No	5	8
397	5x48	5x52	alpha2a_on	0	1.39667	Yes	Yes	No	No	7	5
398	2x66	E1x51	alpha2a_on	0	1.39667	No	No	Yes	No	7	5
399	1x59	8x54	alpha2a_on	0	1.38667	No	No	Yes	Yes	7	8
400	6x26	6x27	alpha2a_on	0	1.36333	No	Yes	No	No	5	6
401	1x34	1x37	alpha2a_on	0	1.32167	No	No	No	No	3	5
402	1x31	1x35	alpha2a_on	0	1.29667	No	No	No	No	0	6
403	5x69	6x26	alpha2a_on	0	1.29333	No	No	No	Yes	5	5
404	6x29	6x33	alpha2a_on	0	1.24833	No	No	Yes	No	8	8
405	6x29	6x32	alpha2a_on	0	1.24333	No	No	No	No	8	9
406	1x38	7x35	alpha2a_on	0	1.175	No	No	No	No	5	7
407	4x59	4x60	alpha2a_on	0	1.16667	No	No	No	No	8	8
408	1x52	8x58	alpha2a_on	0	1.15333	No	No	No	No	8	8
409	1x44	1x48	alpha2a_on	0	1.12667	No	No	No	No	6	5
410	I2x50	I2x51	alpha2a_on	0	1.03	No	No	No	No	9	7
411	6x23	6x26	alpha2a_on	0	1	No	No	No	Yes	0	5
412	1x46	1x47	alpha2a_on	0	0.998333	Yes	Yes	No	No	8	7
413	4x62	E2x51	alpha2a_on	0	0.97	No	No	No	No	6	4
414	8x56	8x57	alpha2a_on	0	0.968333	No	No	No	No	7	8
415	1x29	1x30	alpha2a_on	0	0.886667	No	No	No	No	0	0
416	5x38	5x42	alpha2a_on	0	0.823333	No	No	No	No	5	7
417	6x24	6x25	alpha2a_on	0	0.75	No	No	No	No	0	0
418	1x32	1x33	alpha2a_on	0	0.735	No	No	No	No	4	5
419	E3.C416	E3.V418	alpha2a_on	0	0.57	No	No	No	No	8	6
420	6x25	6x28	alpha2a_on	0	0.566667	No	No	No	No	0	5
421	4x60	4x61	alpha2a_on	0	0.546667	No	No	No	No	8	7
422	4x51	4x55	alpha2a_on	0	0.506667	No	No	No	No	5	6
423	5x70	6x26	alpha2a_on	0	0.431667	No	No	No	Yes	0	5
424	6x22	6x24	alpha2a_on	0	0.355	No	No	No	No	0	0
425	I2x55	I2x56	alpha2a_on	0	0.235	No	No	No	Yes	6	6

Orange: nodes, hubs and links specific of alpha2a_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of alpha2a_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	alpha2a_off Avg Int. Strength	alpha2a_on Avg Int. Strength	alpha2a_off Num Of Links	alpha2a_on Num Of Links	ConSurf
1	I1x51	alpha2a_off	5.3375	1.75417	4	2	7
2	2x42	alpha2a_off	6.28	4.71167	4	3	8
3	2x65	alpha2a_off	2.29	1.3	4	2	7
4	E1x49	alpha2a_off	7.7975	5.74333	4	1	5
5	E1x51	alpha2a_off	14.8283	2.37167	6	2	5
6	3x28	alpha2a_off	6.72333	3.36111	6	3	7
7	3x42	alpha2a_off	8.9875	4.82556	4	3	8
8	3x43	alpha2a_off	4.7425	4.77444	4	3	8
9	3x50	alpha2a_off	7.1725	4.105	4	2	9
10	4x50	alpha2a_off	8.256	4.97	5	2	9
11	E2.I187	alpha2a_off	3.71	0	4	0	6
12	5x39	alpha2a_off	5.15	4.68	4	3	8
13	5x54	alpha2a_off	4.7425	5.39	4	1	9
14	6x31	alpha2a_off	8.385	2.93833	4	1	7
15	6x33	alpha2a_off	6.4625	3.72167	4	3	8
16	1x46	Shared	4.755	2.54292	4	4	8
17	1x50	Shared	7.044	5.12625	5	4	9
18	2x45	Shared	5.96	3.66833	4	4	9
19	E1x50	Shared	2.08	4.04917	4	6	8
20	3x37	Shared	5.9575	2.77292	4	4	8
21	4x53	Shared	3.7375	2.85375	4	4	8
22	5x47	Shared	11.635	7.27067	4	5	9
23	5x48	Shared	5.175	3.236	4	5	7
24	6x48	Shared	9.034	6.57139	5	6	9
25	6x51	Shared	11.705	6.50133	4	5	8
26	6x52	Shared	9.62833	6.33083	6	6	8
27	7x37	Shared	6.6075	5.50833	4	4	7
28	7x42	Shared	5.73	5.43389	4	6	8
29	7x53	Shared	6.9	4.16278	4	6	9
30	8x50	Shared	6.964	6.73633	5	5	8
31	8x54	Shared	5.612	4.66333	5	5	8
32	Lig	Shared	10.45	7.62958	9	12	0
33	I1x50	alpha2a_on	2.855	4.52267	2	5	9
34	3x35	alpha2a_on	8.27333	4.92667	3	5	7
35	3x45	alpha2a_on	1.7	2.90667	1	4	8
36	I2x56	alpha2a_on	17.33	2.57125	1	4	6
37	I2x57	alpha2a_on	8.93667	4.405	3	6	7
38	4x40	alpha2a_on	1.29	3.18333	1	4	5
39	E2x50	alpha2a_on	10.94	3.69417	3	4	9
40	5x57	alpha2a_on	5.575	2.6825	2	4	8
41	5x58	alpha2a_on	7.01	4.024	3	5	9
42	6x26	alpha2a_on	0	1.02208	0	4	5
43	6x44	alpha2a_on	6.64333	4.39125	3	4	9
44	6x55	alpha2a_on	8.96	4.664	3	5	8
45	7x49	alpha2a_on	5.53667	3.83083	3	4	9

Orange: nodes, hubs and links specific of alpha2a_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of alpha2a_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	alpha2a_off Recurrence	alpha2a_on Recurrence	alpha2a_off Hub1?	alpha2a_on Hub1?	alpha2a_off Hub2?	alpha2a_on Hub2?	ConSurf1	ConSurf2
1	1x35	NT.L30	alpha2a_off	11.1614	0	No	No	No	No	6	8
2	2x65	NT.L30	alpha2a_off	14.5917	0	Yes	No	No	No	7	8
3	2x61	2x65	alpha2a_off	14.5976	0	No	No	Yes	No	8	7
4	2x65	2x66	alpha2a_off	36.2379	5.3024	Yes	No	No	No	7	7
5	2x66	E1x50	alpha2a_off	43.7338	0	No	No	Yes	Yes	7	8
6	E1x50	E1x52	alpha2a_off	58.5844	3.23332	Yes	Yes	No	No	8	7
7	3x24	E1x52	alpha2a_off	62.2676	1.14949	No	No	No	No	6	7
8	2x59	3x24	alpha2a_off	32.337	0	No	No	No	No	7	6
9	2x57	7x42	alpha2a_off	11.0791	0	No	No	Yes	Yes	8	8
10	3x24	E1x51	alpha2a_off	33.6609	0	No	No	Yes	No	6	5
11	3x28	E1x51	alpha2a_off	43.0454	0	Yes	No	Yes	No	7	5
12	3x28	Lig	alpha2a_off	88.2855	0	Yes	No	Yes	Yes	7	0
13	3x32	Lig	alpha2a_off	93.8456	1.79203	No	No	Yes	Yes	8	0
14	2x56	3x32	alpha2a_off	100	0.898962	No	No	No	No	8	8
15	2x53	2x56	alpha2a_off	99.9706	0	No	No	No	No	8	8
16	2x53	7x46	alpha2a_off	99.7588	7.80476	No	No	No	No	8	9
17	1x46	7x46	alpha2a_off	53.6656	0	Yes	Yes	No	No	8	9
18	1x46	1x50	alpha2a_off	49.0056	0	Yes	Yes	Yes	Yes	8	9
19	2x50	7x46	alpha2a_off	46.1285	6.70538	No	No	No	No	9	9
20	1x50	2x50	alpha2a_off	45.546	5.60599	Yes	Yes	No	No	9	9
21	1x50	7x50	alpha2a_off	85.9614	5.60599	Yes	Yes	No	No	9	9
22	7x49	7x50	alpha2a_off	82.7724	0	No	Yes	No	No	9	9
23	7x53	8x50	alpha2a_off	53.0242	0	Yes	Yes	Yes	Yes	9	8
24	8x50	8x54	alpha2a_off	30.0247	0	Yes	Yes	Yes	Yes	8	8
25	1x52	8x54	alpha2a_off	16.6039	7.84897	No	No	Yes	Yes	8	8
26	8x50	I1x51	alpha2a_off	19.4399	0	Yes	Yes	Yes	No	8	7
27	1x60	I1x51	alpha2a_off	10.2554	0	No	No	Yes	No	8	7
28	2x43	7x53	alpha2a_off	23.6585	0	No	No	Yes	Yes	8	9
29	6x51	Lig	alpha2a_off	40.2859	7.91971	Yes	Yes	Yes	Yes	8	0
30	6x48	6x51	alpha2a_off	41.6863	0	Yes	Yes	Yes	Yes	9	8
31	6x44	6x48	alpha2a_off	84.9729	0	No	Yes	Yes	Yes	9	9
32	3x43	5x54	alpha2a_off	72.4523	0	Yes	No	Yes	No	8	9
33	3x47	5x54	alpha2a_off	69.6105	0	No	No	Yes	No	9	9
34	5x57	5x61	alpha2a_off	67.3394	0	No	Yes	No	No	8	9
35	5x58	5x61	alpha2a_off	66.4686	0	No	Yes	No	No	9	9
36	3x50	6x37	alpha2a_off	53.4655	0	Yes	No	No	No	9	8
37	3x49	3x50	alpha2a_off	58.9021	0	No	No	Yes	No	9	9
38	2x39	3x49	alpha2a_off	25.8178	0	No	No	No	No	9	9
39	2x39	I2x57	alpha2a_off	23.8233	3.84933	No	No	No	Yes	9	7
40	6x52	Lig	alpha2a_off	72.2288	7.65739	Yes	Yes	Yes	Yes	8	0
41	6x48	6x52	alpha2a_off	49.2998	8.66836	Yes	Yes	Yes	Yes	9	8
42	2x38	4x39	alpha2a_off	12.0558	0	No	No	No	No	7	6
43	2x43	6x33	alpha2a_off	20.4342	0	No	No	Yes	No	8	8
44	6x33	6x37	alpha2a_off	10.0082	0	Yes	No	No	No	8	8
45	3x33	Lig	alpha2a_off	66.8922	4.39755	No	No	Yes	Yes	8	0
46	3x33	4x57	alpha2a_off	65.3566	3.43669	No	No	No	No	8	8
47	3x34	4x57	alpha2a_off	36.6616	2.29604	No	No	No	No	7	8
48	3x34	4x50	alpha2a_off	32.9783	0	No	No	Yes	No	7	9
49	2x45	4x50	alpha2a_off	22.5759	0	Yes	Yes	Yes	No	9	9
50	2x45	4x46	alpha2a_off	19.6517	1.36171	Yes	Yes	No	No	9	8
51	2x42	4x46	alpha2a_off	10.9438	0	Yes	No	No	No	8	8
52	3x28	3x29	alpha2a_off	10.173	0	Yes	No	No	No	7	7
53	E2x52	Lig	alpha2a_off	18.1807	0	No	No	Yes	Yes	7	0
54	3x37	4x57	alpha2a_off	28.3243	0	Yes	Yes	No	No	8	8
55	3x37	4x53	alpha2a_off	25.7531	8.72436	Yes	Yes	Yes	Yes	8	8
56	3x41	4x53	alpha2a_off	18.069	1.36171	No	No	Yes	Yes	7	8
57	3x49	I2x53	alpha2a_off	32.7371	1.2556	No	No	No	No	9	9
58	3x50	6x34	alpha2a_off	14.068	0	Yes	No	No	No	9	8
59	3x51	3x52	alpha2a_off	19.1516	0	No	No	No	No	8	6
60	5x43	Lig	alpha2a_off	18.3867	9.92101	No	No	Yes	Yes	9	0
61	5x39	5x43	alpha2a_off	16.6098	9.05152	Yes	No	No	No	8	9
62	6x31	6x34	alpha2a_off	11.9793	0	Yes	No	No	No	7	8
63	6x40	7x49	alpha2a_off	20.0459	0	No	No	No	Yes	8	9
64	6x40	7x52	alpha2a_off	17.5747	0	No	No	No	No	8	8
65	7x52	7x56	alpha2a_off	10.1141	0	No	No	No	No	8	8
66	6x49	6x50	alpha2a_off	16.9922	0	No	No	No	No	7	9
67	6x50	7x37	alpha2a_off	15.1506	2.71457	No	No	Yes	Yes	9	7
68	3x50	6x33	alpha2a_off	19.4458	0	Yes	No	Yes	No	9	8
69	3x29	E2.I187	alpha2a_off	14.0857	0	No	No	Yes	No	7	6
70	2x59	3x28	Shared	33.9492	27.5495	No	No	Yes	No	7	7
71	7x49	7x53	Shared	68.5926	89.2007	No	Yes	Yes	Yes	9	9
72	3x43	6x44	Shared	80.3483	24.6552	Yes	No	No	Yes	8	9
73	3x47	5x57	Shared	68.422	98.373	No	No	No	Yes	9	8
74	5x58	6x37	Shared	64.4858	23.5322	No	Yes	No	No	9	8
75	2x38	I2x57	Shared	16.7981	36.5598	No	No	No	Yes	7	7
76	2x53	3x35	Shared	10.4377	16.591	No	No	No	Yes	8	7
77	3x52	I2x53	Shared	23.8233	45.7528	No	No	No	No	6	9
78	5x47	6x52	Shared	32.5253	13.8853	Yes	Yes	Yes	Yes	9	8
79	5x47	6x49	Shared	29.554	12.6415	Yes	Yes	No	No	9	7
80	6x49	6x53	Shared	11.4321	10.3955	No	No	No	No	7	7
81	7x35	7x39	alpha2a_on	0	10.6284	No	No	No	No	7	7
82	7x39	7x42	alpha2a_on	0	11.7514	No	No	Yes	Yes	7	8
83	2x60	7x42	alpha2a_on	3.38315	14.5868	No	No	Yes	Yes	8	8
84	1x46	2x60	alpha2a_on	0	13.6819	Yes	Yes	No	No	8	8
85	7x42	Lig	alpha2a_on	8.0313	26.6476	Yes	Yes	Yes	Yes	8	0
86	3x35	Lig	alpha2a_on	0	45.7469	No	Yes	Yes	Yes	7	0
87	6x48	Lig	alpha2a_on	0	77.4847	Yes	Yes	Yes	Yes	9	0
88	6x48	7x45	alpha2a_on	0	87.8507	Yes	Yes	No	No	9	9
89	7x45	7x49	alpha2a_on	0	88.8499	No	No	No	Yes	9	9
90	6x40	7x53	alpha2a_on	0	58.1555	No	No	Yes	Yes	8	9
91	5x58	6x40	alpha2a_on	0	58.0288	No	Yes	No	No	9	8
92	3x47	5x58	alpha2a_on	0	100	No	No	No	Yes	9	9
93	3x51	5x57	alpha2a_on	0	89.9434	No	No	No	Yes	8	8
94	3x51	3x55	alpha2a_on	7.26642	86.4537	No	No	No	No	8	7
95	3x55	I2x56	alpha2a_on	0	84.6381	No	No	No	Yes	7	6
96	4x40	I2x56	alpha2a_on	0	82.0591	No	Yes	No	Yes	5	6
97	3x52	4x40	alpha2a_on	0	48.0105	No	No	No	Yes	6	5
98	I2x53	I2x57	alpha2a_on	0	43.3477	No	No	No	Yes	9	7
99	2x38	8x50	alpha2a_on	0	25.5512	No	No	Yes	Yes	7	8
100	7x54	8x50	alpha2a_on	0	16.5704	No	No	Yes	Yes	9	8
101	7x54	8x54	alpha2a_on	8.39609	15.2676	No	No	Yes	Yes	9	8
102	3x50	7x53	alpha2a_on	0	58.1732	Yes	No	Yes	Yes	9	9
103	3x50	5x58	alpha2a_on	0	58.0877	Yes	No	No	Yes	9	9
104	2x38	I1x50	alpha2a_on	0	10.0212	No	No	No	Yes	7	9
105	2x42	4x40	alpha2a_on	0	37.3497	Yes	No	No	Yes	8	5
106	2x42	4x45	alpha2a_on	2.24759	32.7606	Yes	No	No	No	8	7
107	2x45	4x45	alpha2a_on	0	31.5315	Yes	Yes	No	No	9	7
108	2x45	3x42	alpha2a_on	1.35326	27.8443	Yes	Yes	Yes	No	9	8
109	2x59	3x35	alpha2a_on	0	28.3718	No	No	No	Yes	7	7
110	3x28	E2x50	alpha2a_on	3.41845	19.7418	Yes	No	No	Yes	7	9
111	E1x50	E2x50	alpha2a_on	0	15.8866	Yes	Yes	No	Yes	8	9
112	3x42	4x50	alpha2a_on	5.78371	25.3566	Yes	No	Yes	No	8	9
113	3x38	4x50	alpha2a_on	3.40668	24.104	No	No	Yes	No	8	9
114	3x38	4x53	alpha2a_on	4.97764	20.4315	No	No	Yes	Yes	8	8
115	5x47	6x44	alpha2a_on	0	23.2433	Yes	Yes	No	Yes	9	9
116	5x62	6x37	alpha2a_on	0	22.4181	No	No	No	No	8	8
117	5x62	5x66	alpha2a_on	0.00588374	20.1309	No	No	No	No	8	8
118	5x66	6x30	alpha2a_on	0	18.8428	No	No	No	No	8	9
119	6x30	6x33	alpha2a_on	0	10.2305	No	No	Yes	No	9	8
120	7x52	7x53	alpha2a_on	0	10.4899	No	No	Yes	Yes	8	9
121	6x51	7x34	alpha2a_on	0	18.3919	Yes	Yes	No	No	8	6
122	6x54	7x34	alpha2a_on	5.76018	16.2079	No	No	No	No	7	6
123	6x54	7x37	alpha2a_on	7.66063	13.5228	No	No	Yes	Yes	7	7
124	3x43	7x53	alpha2a_on	0	24.7672	Yes	No	Yes	Yes	8	9
125	6x51	6x52	alpha2a_on	0.764886	12.951	Yes	Yes	Yes	Yes	8	8

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
2x52	3x35	Shared	10.96	7.91667	0	0	2	1
2x53	2x56	alpha2a_off	8.02	0	0	0	2	2
2x53	3x35	Shared	6.55	4.80667	0	0	2	1
2x56	3x32	Shared	5.84	5.11167	0	1	2	1
2x59	3x28	Shared	7.22	4.81333	0	0	2	1
2x60	3x28	alpha2a_off	7.63	0	0	0	2	1
2x60	7x42	Shared	6.36	3.96667	0	0	2	1
3x28	E1x51	alpha2a_off	8.94	0	1	0	1	2
E1x51	E2x50	alpha2a_off	20.16	0	1	0	2	2
3x28	3x29	alpha2a_off	4.69	0	1	0	1	2
3x28	E2x50	Shared	5.38	2.875	1	0	1	2
3x28	Lig	alpha2a_off	6.48	0	1	0	1	0
3x29	E2x52	alpha2a_off	8.56	0	0	0	2	1
3x31	3x35	Shared	7.31	4.06	0	0	2	1
3x32	7x42	Shared	4.6	4.21667	1	1	1	1
3x32	Lig	Shared	26.78	9.28667	1	1	1	0
3x33	4x57	Shared	6.46	4.03833	0	0	1	2
3x33	Lig	Shared	8.23	9.71833	0	0	1	0
3x36	6x48	Shared	10.45	3.04667	0	1	1	1
6x55	E2x52	Shared	4.84	3.62667	0	1	1	1
E2x52	Lig	alpha2a_off	10.14	0	0	0	1	0
6x55	E2.D207	alpha2a_off	6.9	0	0	1	1	2
5x39	5x43	Shared	6.36	4.66333	0	3	2	1
5x40	6x55	Shared	15.14	3.995	0	0	2	1
5x44	6x52	Shared	4.19	3.025	0	0	2	1
5x47	5x48	Shared	7.5	5.36	1	1	2	2
5x47	6x52	Shared	23.58	16.7767	1	1	2	1
5x48	6x52	Shared	4.29	4.10833	1	1	2	1
6x44	6x48	alpha2a_off	9.02	0	0	1	2	1
6x44	7x45	alpha2a_off	6.04	0	0	1	2	2
6x48	6x51	alpha2a_off	7.02	0	1	1	1	1
6x48	6x52	Shared	6.01	7.35	1	1	1	1
6x48	7x41	Shared	12.67	7.97333	1	1	1	2
6x51	6x52	Shared	13.93	3.395	1	1	1	1
6x51	7x38	Shared	8.57	5.89333	1	1	1	1
6x51	Lig	Shared	17.3	10.505	1	1	1	0
6x52	Lig	Shared	5.77	3.33	1	1	1	0
7x35	7x38	alpha2a_off	4.96	0	1	0	2	1
7x38	Lig	Shared	8.65	16.11	1	1	1	0
7x42	Lig	Shared	8.33	9.28333	1	1	1	0
2x57	7x42	alpha2a_off	3.63	0	0	0	2	1
2x46	3x39	alpha2a_off	3	0	0	0	2	1
5x43	Lig	Shared	2.37	4.67667	0	0	1	0
2x56	7x42	alpha2a_on	0	3.155	0	1	2	1
3x36	Lig	alpha2a_on	0	11.5383	0	1	1	0
3x40	6x48	alpha2a_on	0	7.43667	0	0	2	1
6x48	7x45	alpha2a_on	0	9.605	1	1	1	2
6x48	Lig	alpha2a_on	0	4.01667	1	1	1	0
6x51	6x55	alpha2a_on	0	8.425	1	1	1	1
6x55	Lig	alpha2a_on	0	5.59167	0	1	1	0
7x35	7x39	alpha2a_on	0	3.67333	1	0	2	2
7x38	7x42	alpha2a_on	0	8.76667	1	1	1	1
7x39	7x42	alpha2a_on	0	3.215	0	0	2	1
5x47	6x44	alpha2a_on	0	3.75167	1	1	2	2
6x51	7x34	alpha2a_on	0	4.28833	1	1	1	2
3x35	Lig	alpha2a_on	0	5.17333	0	0	1	0
2x59	3x35	alpha2a_on	0	2.67667	0	0	2	1
3x21	3x28	alpha2a_on	0	2.395	0	0	2	1
3x39	Lig	alpha2a_on	0	2.325	0	0	1	0
E2.D207	E2x51	alpha2a_on	0	1.94833	0	0	2	2
5x41	6x55	alpha2a_on	0	1.68167	0	0	2	1
E2x51	E2x52	alpha2a_on	0	1.59333	0	0	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	alpha2a_off	6KUX-α_2a-RS-79948
	alpha2a_on	7EJ0-α_2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α_2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α_2a-W58-Go/&β;1/&γ;2 7W6P-α_2a-W96-Go/&β;1/&γ;2 7EJ8-α_2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α_2a-Dexmedetomidine-Go/&β;1/&γ;2

Network Difference
Value	alpha2a_off	alpha2a_on
I_min	4.18	2.84
Number of Linked Nodes	248	267
Number of Specific Nodes	9 (3.63%)	28 (10.49%)
Number of Shared Nodes	239 (96.37%)	239 (89.51%)
Number of Links	268	283
Number of Specific Links	142 (52.99%)	157 (55.48%)
Number of Shared Links	126 (47.01%)	126 (44.52%)
Number of Hubs	32	30
Number of Specific Hubs	15 (46.88%)	13 (43.33%)
Number of Shared Hubs	17 (53.13%)	17 (56.67%)
Average % Shared Neighbours (Jaccard)	32.05
Average % Shared Neighbours (Otsuka)	40.16
Average % Shared Neighbours (Overlap Coefficient)	47.01
Average % Shared Cliques (k3-6)	79.00
Graphlets Similarity	0.523576

Paths Difference
Value	alpha2a_off	alpha2a_on
Number Of Nodes in MetaPath	77	56
Specific Nodes in MetaPath	39 (50.65%)	18 (32.14%)
Shared Nodes in MetaPath	239 (96.37%)	239 (96.37%)
Number Of Links MetaPath	80	56
Specific Links in MetaPath	69 (86.25%)	45 (80.36%)
Shared Links in MetaPath	126 (47.01%)	126 (47.01%)
Number of Shortest Paths	48788	58036
Length Of Smallest Path	3	3
Average Path Length	14.4488	17.0198
Length of Longest Path	31	36
Minimum Path Strength	1.29	0.557222
Average Path Strength	7.2384	4.48414
Maximum Path Strength	22.73	13.8242
Minimum Path Correlation	0.7	0.7
Average Path Correlation	0.921891	0.91097
Maximum Path Correlation	0.99	0.99
Minimum % Of Corr. Nodes	4.16667	3.125
Average % Of Corr. Nodes	45.4479	33.858
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	37.4652	41.9016
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

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