psnGPCR

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Orange: nodes, hubs and links specific of amine_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of amine_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	amine_off Int. Strength	amine_on Int. Strength	amine_off Hub1?	amine_on Hub1?	amine_off Hub2?	amine_on Hub2?	ConSurf1	ConSurf2
1	1x46	2x54	amine_off	100	0	No	No	No	No	7	6
2	1x53	7x53	amine_off	100	0	No	No	Yes	Yes	9	9
3	8x49	I1x50	amine_off	100	0	No	No	Yes	No	6	8
4	2x39	3x50	amine_off	100	0	No	No	Yes	No	8	9
5	2x41	4x39	amine_off	100	0	No	No	No	No	4	4
6	2x42	4x46	amine_off	100	0	Yes	Yes	No	No	8	8
7	2x43	7x53	amine_off	100	0	No	No	Yes	Yes	8	9
8	2x53	2x56	amine_off	100	0	No	No	Yes	No	7	8
9	2x57	7x39	amine_off	100	0	Yes	Yes	Yes	No	8	6
10	2x60	7x39	amine_off	100	0	Yes	Yes	Yes	No	7	6
11	2x62	E1x52	amine_off	100	0	No	No	No	No	4	5
12	3x37	4x57	amine_off	100	0	No	No	No	No	7	7
13	3x40	5x50	amine_off	100	0	No	No	No	No	8	9
14	3x43	6x44	amine_off	100	0	No	No	Yes	Yes	8	9
15	3x44	5x54	amine_off	100	0	No	No	No	No	6	8
16	3x48	5x57	amine_off	100	0	No	No	No	No	6	5
17	5x36	5x39	amine_off	100	0	Yes	No	Yes	No	5	7
18	5x51	6x45	amine_off	100	0	No	No	No	No	6	6
19	5x54	6x41	amine_off	100	0	No	No	No	No	8	8
20	5x58	6x38	amine_off	100	0	Yes	Yes	No	No	9	6
21	6x40	7x49	amine_off	100	0	No	No	Yes	Yes	8	9
22	6x44	7x45	amine_off	100	0	Yes	Yes	Yes	No	9	9
23	6x48	6x51	amine_off	100	0	Yes	Yes	Yes	Yes	8	7
24	6x51	7x34	amine_off	100	0	Yes	Yes	Yes	No	7	3
25	6x54	7x34	amine_off	100	0	No	No	Yes	No	5	3
26	6x55	7x34	amine_off	100	0	Yes	No	Yes	No	7	3
27	7x53	8x50	amine_off	100	0	Yes	Yes	Yes	Yes	9	8
28	7x54	8x54	amine_off	100	0	No	No	Yes	Yes	7	6
29	3x50	6x34	amine_off	100	0	Yes	No	No	No	9	7
30	7x49	7x53	amine_off	100	0	Yes	Yes	Yes	Yes	9	9
31	NT	NT	amine_off	100	0	Yes	No	Yes	No	0	0
32	2x59	3x24	amine_off	100	0	No	No	No	No	4	5
33	6x40	7x52	amine_off	65.3333	0	No	No	No	No	8	8
34	3x28	3x29	amine_off	62.381	0	Yes	Yes	No	No	5	5
35	E1x49	E2	amine_off	53.3333	0	No	No	Yes	Yes	4	3
36	2x46	3x39	amine_off	63.3333	0	No	Yes	No	No	9	9
37	3x50	6x30	amine_off	56.6667	0	Yes	No	No	No	9	8
38	2x64	7x39	amine_off	56.6667	0	No	No	Yes	No	5	6
39	5x58	5x62	amine_off	55	0	Yes	Yes	No	Yes	9	5
40	5x48	6x56	amine_off	58	0	No	No	No	No	5	5
41	3x49	3x50	amine_off	60	0	Yes	Yes	Yes	No	9	9
42	3x50	6x37	amine_off	43.6667	0	Yes	No	No	No	9	8
43	4x61	5x39	amine_off	36.6667	0	No	No	Yes	No	6	7
44	3x50	6x33	amine_off	59	0	Yes	No	No	No	9	8
45	5x41	5x45	amine_off	33.3333	0	No	No	No	No	6	4
46	1x54	2x47	amine_off	35.8333	0	No	No	No	No	6	9
47	6x39	7x56	amine_off	51.6667	0	No	No	No	No	6	7
48	5x41	6x59	amine_off	33.3333	0	No	No	No	No	6	5
49	5x36	5x37	amine_off	43.3333	0	Yes	No	No	No	5	4
50	6x59	6x60	amine_off	45	0	No	No	No	No	5	4
51	4x60	E2	amine_off	50	0	No	No	Yes	Yes	7	3
52	5x65	6x31	amine_off	44	0	No	No	No	No	8	5
53	6x26	6x29	amine_off	24.8333	0	No	No	No	No	5	6
54	5x64	5x67	amine_off	56.6667	0	No	No	No	No	6	5
55	7x33	7x37	amine_off	43.3333	0	No	No	No	No	4	5
56	1x52	8x57	amine_off	15.4286	0	No	No	No	No	6	4
57	4x52	4x56	amine_off	31.3333	0	No	No	No	No	5	6
58	1x42	2x57	amine_off	24	0	No	No	Yes	Yes	7	8
59	1x42	7x43	amine_off	25.4286	0	No	No	No	No	7	4
60	8x55	CT	amine_off	21.5476	0	No	No	No	No	3	3
61	4x41	4x45	amine_off	38	0	No	No	No	No	6	6
62	4x68	E2	amine_off	40	0	No	No	Yes	Yes	4	3
63	5x68	6x31	amine_off	33.0476	0	No	No	No	No	7	5
64	8x51	8x55	amine_off	20.1667	0	No	No	No	No	9	3
65	3x23	3x27	amine_off	27.381	0	No	No	No	No	1	4
66	5x64	5x68	amine_off	25.8333	0	No	No	No	No	6	7
67	6x27	6x30	amine_off	18	0	No	No	No	No	5	8
68	7x31	7x35	amine_off	35	0	No	No	No	No	2	4
69	6x43	7x45	amine_off	18.0952	0	No	No	Yes	No	6	9
70	5x51	5x55	amine_off	18.3333	0	No	No	No	No	6	5
71	3x21	3x23	amine_off	23.3333	0	No	No	No	No	7	1
72	2x67	NT	amine_off	20	0	No	No	Yes	No	5	0
73	8x48	8x49	amine_off	20.6667	0	No	No	No	No	5	6
74	1x35	1x39	amine_off	18.0952	0	Yes	No	No	No	3	6
75	2x41	4x43	amine_off	20	0	No	No	No	No	4	4
76	1x31	1x35	amine_off	21.3333	0	No	Yes	Yes	No	3	3
77	7x35	E1	amine_off	20	0	No	No	No	No	4	3
78	6x29	6x30	amine_off	24	0	No	No	No	No	6	8
79	5x60	5x63	amine_off	14	0	No	No	No	No	5	4
80	1x58	2x44	amine_off	11.3333	0	No	No	No	No	1	5
81	6x28	6x32	amine_off	20	0	No	No	No	No	6	8
82	4x44	4x48	amine_off	10.6667	0	No	No	No	No	3	2
83	5x58	I3	amine_off	20	0	Yes	Yes	Yes	Yes	9	0
84	8x59	CT	amine_off	8.66667	0	No	No	No	No	4	3
85	5x76	I3	amine_off	20	0	No	No	Yes	Yes	0	0
86	I2x55	I2x56	amine_off	10	0	No	No	No	No	4	4
87	4x64	4x67	amine_off	20	0	No	No	No	No	4	6
88	1x33	NT	amine_off	20	0	No	No	Yes	No	5	0
89	5x66	5x69	amine_off	10	0	No	No	No	No	6	5
90	1x34	1x35	amine_off	13.3333	0	No	No	Yes	No	4	3
91	3x56	I2x51	amine_off	11.6667	0	Yes	No	No	No	6	7
92	I2x54	I2x57	amine_off	10.3333	0	No	No	Yes	No	6	6
93	5x52	5x56	amine_off	0	0	No	No	No	No	3	5
94	5x72	I3	amine_off	10	0	No	No	Yes	Yes	0	0
95	5x67	5x70	amine_off	11.6667	0	No	No	No	No	5	0
96	6x58	6x62	amine_off	10	0	No	No	No	No	4	0
97	4x43	4x47	amine_off	6.66667	0	No	No	No	No	4	2
98	4x52	4x55	amine_off	3.33333	0	No	No	No	No	5	4
99	4x36	4x40	amine_off	10	0	No	No	No	No	0	5
100	5x71	I3	amine_off	11.6667	0	No	No	Yes	Yes	0	0
101	5x69	6x24	amine_off	4	0	No	No	No	No	5	0
102	1x27	NT	amine_off	4	0	No	No	Yes	No	2	0
103	1x29	1x33	amine_off	4.66667	0	No	No	No	No	3	5
104	8x60	CT	amine_off	10	0	No	No	No	No	8	3
105	5x71	5x74	amine_off	10	0	No	No	No	No	0	0
106	I2	I2x55	amine_off	0	0	No	No	No	No	0	4
107	7x29	7x33	amine_off	3.33333	0	No	No	No	No	5	4
108	2x50	Na1	amine_off	5	0	Yes	Yes	No	No	9	0
109	4x34	4x38	amine_off	3.33333	0	No	No	No	No	0	7
110	4x35	4x39	amine_off	3.33333	0	No	No	No	No	0	4
111	6x21	6x22	amine_off	1.66667	0	No	No	No	No	0	0
112	6x20	6x22	amine_off	0.833333	0	No	No	No	No	0	0
113	5x68	6x20	amine_off	0.833333	0	No	No	No	No	7	0
114	5x73	6x24	amine_off	1.66667	0	No	No	No	No	0	0
115	8x59	8x61	amine_off	0	0	No	No	No	No	4	0
116	1x411	1x42	amine_off	0	0	No	No	No	No	0	7
117	1x26	1x29	amine_off	0.833333	0	No	No	No	No	0	3
118	1x25	1x28	amine_off	0.833333	0	No	No	No	No	0	3
119	1x39	2x61	Shared	100	100	No	No	No	No	6	6
120	1x39	7x39	Shared	100	100	No	No	Yes	No	6	6
121	1x43	2x57	Shared	100	100	No	No	Yes	Yes	6	8
122	1x46	2x57	Shared	100	73.1481	No	No	Yes	Yes	7	8
123	1x46	7x47	Shared	100	100	No	No	No	No	7	6
124	1x49	7x50	Shared	100	37.037	No	No	No	No	8	9
125	1x50	2x50	Shared	100	100	No	Yes	Yes	Yes	9	9
126	1x50	7x50	Shared	100	100	No	Yes	No	No	9	9
127	1x52	8x54	Shared	100	100	No	No	Yes	Yes	6	6
128	1x53	2x47	Shared	100	57.2222	No	No	No	No	9	9
129	1x57	2x44	Shared	100	100	No	No	No	No	7	5
130	1x60	I1x50	Shared	100	100	Yes	Yes	Yes	No	6	8
131	1x60	8x53	Shared	100	62.2685	Yes	Yes	No	No	6	7
132	2x40	I1x50	Shared	100	100	No	No	Yes	No	9	8
133	8x50	I1x50	Shared	100	100	Yes	Yes	Yes	No	8	8
134	2x37	2x40	Shared	100	100	No	No	No	No	7	9
135	2x40	8x50	Shared	100	100	No	No	Yes	Yes	9	8
136	2x42	3x45	Shared	100	100	Yes	Yes	No	No	8	7
137	2x42	3x46	Shared	100	100	Yes	Yes	No	Yes	8	9
138	2x45	3x42	Shared	100	100	No	No	No	No	9	8
139	2x45	4x46	Shared	100	100	No	No	No	No	9	8
140	2x45	4x50	Shared	100	100	No	No	No	No	9	9
141	2x50	3x39	Shared	100	100	Yes	Yes	No	No	9	9
142	2x50	7x46	Shared	100	100	Yes	Yes	No	No	9	9
143	2x50	7x49	Shared	100	100	Yes	Yes	Yes	Yes	9	9
144	2x52	3x35	Shared	100	100	No	No	No	No	7	7
145	2x53	7x46	Shared	100	100	No	No	No	No	7	9
146	2x55	2x551	Shared	100	40.3858	No	No	No	No	4	5
147	2x56	3x28	Shared	100	100	Yes	No	Yes	Yes	8	5
148	2x56	3x32	Shared	100	100	Yes	No	No	No	8	8
149	2x56	7x42	Shared	100	100	Yes	No	Yes	Yes	8	7
150	2x57	7x42	Shared	100	100	Yes	Yes	Yes	Yes	8	7
151	2x59	3x28	Shared	100	100	No	No	Yes	Yes	4	5
152	2x60	3x28	Shared	100	100	Yes	Yes	Yes	Yes	7	5
153	2x60	7x42	Shared	100	100	Yes	Yes	Yes	Yes	7	7
154	2x63	E1x50	Shared	100	100	No	No	Yes	Yes	5	7
155	E1x50	E1x52	Shared	100	100	Yes	Yes	No	No	7	5
156	3x25	E1x50	Shared	100	100	No	No	Yes	Yes	9	7
157	3x28	E1x50	Shared	100	100	Yes	Yes	Yes	Yes	5	7
158	E1x50	E2x50	Shared	100	100	Yes	Yes	No	No	7	9
159	3x24	E1x52	Shared	100	100	No	No	No	No	5	5
160	3x22	E2	Shared	100	100	No	No	Yes	Yes	3	3
161	3x25	E2x50	Shared	100	100	No	No	No	No	9	9
162	3x26	E2	Shared	100	59.7222	No	No	Yes	Yes	6	3
163	3x30	4x62	Shared	100	36.2731	No	No	No	No	6	5
164	3x32	7x42	Shared	100	100	No	No	Yes	Yes	8	7
165	3x32	Lig	Shared	100	100	No	No	Yes	Yes	8	0
166	3x33	4x57	Shared	100	100	No	No	No	No	6	7
167	3x33	Lig	Shared	100	100	No	No	Yes	Yes	6	0
168	3x34	4x54	Shared	100	48.0556	No	No	No	No	6	4
169	3x36	6x48	Shared	100	100	No	No	Yes	Yes	7	8
170	3x36	Lig	Shared	100	100	No	No	Yes	Yes	7	0
171	3x37	4x53	Shared	100	100	No	No	No	No	7	8
172	3x37	5x461	Shared	100	100	No	No	No	No	7	6
173	3x38	4x50	Shared	100	100	No	No	No	No	8	9
174	3x40	6x44	Shared	100	100	No	No	Yes	Yes	8	9
175	3x41	5x50	Shared	100	50.3009	No	No	No	No	6	9
176	3x42	4x49	Shared	100	100	No	No	No	No	8	6
177	3x44	5x53	Shared	100	100	No	No	No	No	6	6
178	3x47	5x54	Shared	100	100	No	No	No	No	9	8
179	3x47	5x57	Shared	100	100	No	No	No	No	9	5
180	3x51	3x55	Shared	100	100	Yes	Yes	No	No	8	6
181	3x51	5x57	Shared	100	100	Yes	Yes	No	No	8	5
182	3x51	5x60	Shared	100	100	Yes	Yes	No	No	8	5
183	4x64	E2	Shared	100	100	No	No	Yes	Yes	4	3
184	4x65	E2	Shared	100	20.8333	No	No	Yes	Yes	7	3
185	E2	E2	Shared	100	100	Yes	Yes	Yes	Yes	3	3
186	5x36	E2	Shared	100	100	Yes	No	Yes	Yes	5	3
187	5x39	E2	Shared	100	100	Yes	No	Yes	Yes	7	3
188	E2	E2x51	Shared	100	100	Yes	Yes	No	No	3	4
189	E2x52	Lig	Shared	100	100	No	No	Yes	Yes	4	0
190	5x36	5x38	Shared	100	65.9491	Yes	No	No	No	5	3
191	5x40	6x55	Shared	100	100	No	No	Yes	No	6	7
192	5x43	Lig	Shared	100	100	No	No	Yes	Yes	6	0
193	5x461	Lig	Shared	100	100	No	No	Yes	Yes	6	0
194	5x47	5x48	Shared	100	100	No	Yes	No	No	8	5
195	5x47	6x52	Shared	100	100	No	Yes	Yes	Yes	8	7
196	6x44	6x48	Shared	100	100	Yes	Yes	Yes	Yes	9	8
197	6x47	7x45	Shared	100	100	No	No	Yes	No	8	9
198	6x48	6x52	Shared	100	100	Yes	Yes	Yes	Yes	8	7
199	6x48	7x41	Shared	100	100	Yes	Yes	No	No	8	7
200	6x48	7x45	Shared	100	100	Yes	Yes	Yes	No	8	9
201	6x48	Lig	Shared	100	100	Yes	Yes	Yes	Yes	8	0
202	6x50	7x37	Shared	100	100	No	No	No	No	9	5
203	6x51	6x52	Shared	100	100	Yes	Yes	Yes	Yes	7	7
204	6x51	6x55	Shared	100	100	Yes	Yes	Yes	No	7	7
205	6x51	7x38	Shared	100	100	Yes	Yes	Yes	Yes	7	6
206	6x51	Lig	Shared	100	100	Yes	Yes	Yes	Yes	7	0
207	6x52	Lig	Shared	100	100	Yes	Yes	Yes	Yes	7	0
208	6x54	7x37	Shared	100	100	No	No	No	No	5	5
209	6x55	Lig	Shared	100	100	Yes	No	Yes	Yes	7	0
210	6x61	E3	Shared	100	100	No	No	No	Yes	3	3
211	7x38	7x42	Shared	100	100	Yes	Yes	Yes	Yes	6	7
212	7x38	Lig	Shared	100	100	Yes	Yes	Yes	Yes	6	0
213	7x39	7x42	Shared	100	100	Yes	No	Yes	Yes	6	7
214	7x42	Lig	Shared	100	100	Yes	Yes	Yes	Yes	7	0
215	8x47	8x49	Shared	100	100	No	No	No	No	9	6
216	8x47	8x50	Shared	100	100	No	No	Yes	Yes	9	8
217	8x50	8x54	Shared	100	43.7963	Yes	Yes	Yes	Yes	8	6
218	1x60	I1x49	Shared	100	100	Yes	Yes	No	No	6	6
219	2x42	3x49	Shared	100	100	Yes	Yes	Yes	Yes	8	9
220	2x46	3x42	Shared	100	100	No	Yes	No	No	9	8
221	3x41	4x52	Shared	100	38.7963	No	No	No	No	6	5
222	3x48	3x52	Shared	100	100	No	No	No	No	6	5
223	5x47	5x51	Shared	100	100	No	Yes	No	No	8	6
224	5x58	6x41	Shared	100	100	Yes	Yes	No	No	9	8
225	5x62	5x66	Shared	100	100	No	Yes	No	No	5	6
226	6x49	6x53	Shared	100	44.1667	No	Yes	No	No	6	6
227	3x30	4x61	Shared	100	54.8611	No	No	No	No	6	6
228	7x45	7x49	Shared	100	100	Yes	No	Yes	Yes	9	9
229	2x38	I2x57	Shared	100	40.0463	No	No	Yes	No	5	6
230	I2x53	I2x57	Shared	100	100	Yes	Yes	Yes	No	7	6
231	E2	E2x52	Shared	100	100	Yes	Yes	No	No	3	4
232	3x45	4x45	Shared	100	100	No	No	No	No	7	6
233	3x49	I2x53	Shared	100	100	Yes	Yes	Yes	Yes	9	7
234	3x49	I2x57	Shared	100	100	Yes	Yes	Yes	No	9	6
235	3x52	I2x53	Shared	100	100	No	No	Yes	Yes	5	7
236	2x64	7x35	Shared	100	100	No	No	No	No	5	4
237	5x39	5x43	Shared	100	100	Yes	No	No	No	7	6
238	2x60	7x38	Shared	100	100	Yes	Yes	Yes	Yes	7	6
239	I1x48	I1x51	Shared	75.8333	100	No	No	No	No	6	7
240	3x34	4x57	Shared	60	54.1667	No	No	No	No	6	7
241	1x43	2x58	Shared	66.3333	53.6883	No	No	No	No	6	8
242	3x51	5x61	Shared	72	36.1111	Yes	Yes	No	No	8	9
243	7x30	7x33	Shared	56.6667	100	No	Yes	No	No	4	4
244	5x49	5x50	Shared	60	64.1204	No	No	No	No	5	9
245	6x58	E3	Shared	50.6667	100	No	No	No	Yes	4	3
246	6x39	7x52	Shared	49.3333	13.75	No	No	No	No	6	8
247	3x56	I2x52	Shared	61.6667	100	Yes	No	No	Yes	6	5
248	6x36	7x56	Shared	58	100	No	No	No	No	8	7
249	7x55	7x56	Shared	36.6667	18.1481	No	No	No	No	5	7
250	1x51	2x51	Shared	59.1429	52.7778	No	No	No	No	3	7
251	2x551	3x31	Shared	51.5	100	No	No	No	No	5	5
252	1x56	8x54	Shared	41.5	35.4861	No	No	Yes	Yes	7	6
253	6x58	7x34	Shared	50.8333	100	No	No	Yes	No	4	3
254	4x41	I2x56	Shared	38.8333	23.9583	No	No	No	No	6	4
255	2x49	4x50	Shared	20	100	No	No	No	No	8	9
256	2x53	3x35	Shared	47.3333	100	No	No	No	No	7	7
257	6x49	6x50	Shared	42.1667	42.3843	No	Yes	No	No	6	9
258	E1x49	E1x51	Shared	48	100	No	No	No	No	4	3
259	8x48	8x51	Shared	54	27.963	No	No	No	No	5	9
260	1x55	8x57	Shared	55.8333	37.2222	No	No	No	No	4	4
261	4x59	4x60	Shared	48.2143	48.3333	No	No	No	No	4	7
262	2x66	E1x51	Shared	53.3333	35.2778	No	No	No	No	4	3
263	3x54	5x64	Shared	50	27.3148	No	No	No	No	9	6
264	5x44	6x52	Shared	56.6667	100	No	No	Yes	Yes	6	7
265	3x27	3x31	Shared	30	23.4877	No	No	No	No	4	5
266	8x48	8x52	Shared	42.3333	11.6667	No	No	No	No	5	4
267	2x41	I1x51	Shared	45.4286	29.0509	No	No	No	No	4	7
268	3x53	I2x53	Shared	60	100	No	No	Yes	Yes	8	7
269	2x42	4x42	Shared	38.8333	54.6759	Yes	Yes	No	No	8	7
270	1x47	2x51	Shared	49.8571	24.0432	No	No	No	No	5	7
271	3x30	4x58	Shared	40	100	No	No	No	No	6	0
272	1x50	2x51	Shared	30	100	No	Yes	No	No	9	7
273	1x54	2x44	Shared	26.6667	40.9259	No	No	No	No	6	5
274	6x57	E3	Shared	47.381	45.3086	No	No	No	Yes	4	3
275	7x43	7x48	Shared	41.6667	27.1296	No	No	No	No	4	6
276	6x50	7x40	Shared	54.1667	18.1713	No	No	No	No	9	7
277	1x47	2x55	Shared	38	28.2562	No	No	No	No	5	4
278	5x45	5x48	Shared	42.0476	100	No	No	No	No	4	5
279	4x63	E2	Shared	46.6667	49.537	No	No	Yes	Yes	5	3
280	5x56	5x60	Shared	42	49.2361	No	No	No	No	5	5
281	1x54	2x48	Shared	35.381	23.9815	No	No	No	No	6	6
282	4x38	4x41	Shared	43.3333	100	No	No	No	No	7	6
283	7x30	7x32	Shared	40	35.3241	No	Yes	No	No	4	1
284	1x45	7x47	Shared	20.5	25.2778	No	No	No	No	4	6
285	3x54	5x61	Shared	28.9286	53.4259	No	No	No	No	9	9
286	3x55	3x56	Shared	30.8333	22.6157	No	No	Yes	No	6	6
287	1x32	2x65	Shared	36.381	7.75463	No	No	No	No	6	5
288	1x36	2x65	Shared	22.5	34.0278	No	No	No	No	6	5
289	4x38	4x40	Shared	20.6667	29.0895	No	No	No	No	7	5
290	2x38	4x39	Shared	39.6667	49.6142	No	No	No	No	5	4
291	4x56	5x46	Shared	26.3333	29.537	No	No	No	No	6	4
292	1x59	8x57	Shared	30.7143	34.2593	No	No	No	No	5	4
293	3x56	I2x50	Shared	8.80952	15.8951	Yes	No	No	No	6	8
294	4x65	4x66	Shared	20	16.6667	No	No	No	No	7	5
295	1x48	1x49	Shared	11.4286	11.3426	No	No	No	No	4	8
296	7x36	7x40	Shared	30	26.7593	No	No	No	No	4	7
297	6x35	6x39	Shared	24.1667	36.1111	No	No	No	No	7	6
298	1x52	8x58	Shared	14.8333	10.8333	No	No	No	No	6	6
299	1x60	8x56	Shared	28.3333	36.0185	Yes	Yes	No	No	6	4
300	5x42	5x46	Shared	20	6.48148	No	No	No	No	4	4
301	1x32	NT	Shared	20	2.91667	No	No	Yes	No	6	0
302	1x40	2x61	Shared	23.3333	8.98148	No	No	No	No	3	6
303	6x28	6x31	Shared	21.3333	4.65278	No	No	No	No	6	5
304	1x35	2x65	Shared	8	11.6744	Yes	No	No	No	3	5
305	5x59	5x63	Shared	23.3333	100	No	No	No	No	1	4
306	7x51	7x55	Shared	15.3333	26.2963	No	No	No	No	6	5
307	1x34	1x38	Shared	20	12.9398	No	No	No	No	4	4
308	1x28	1x31	Shared	20.6667	5.55556	No	No	No	Yes	3	3
309	6x42	6x46	Shared	15.3333	3.81944	No	No	No	No	5	5
310	6x25	6x29	Shared	20.8333	19.4444	No	No	No	No	5	6
311	1x41	1x45	Shared	7.33333	6.71296	No	No	No	No	4	4
312	4x51	4x55	Shared	1.33333	2.82407	No	No	No	No	4	4
313	4x40	4x44	Shared	7.66667	13.6343	No	No	No	No	5	3
314	7x26	7x29	Shared	10	2.77778	No	No	No	No	1	5
315	6x41	6x42	Shared	0	0	No	No	No	No	8	5
316	1x44	1x48	Shared	4.71429	9.02778	No	No	No	No	4	4
317	1x33	1x37	Shared	4.66667	0.385802	No	No	No	No	5	4
318	7x27	E2	Shared	10	0	No	No	Yes	Yes	3	3
319	1x29	1x30	Shared	11.3333	17.3611	No	No	No	No	3	1
320	7x26	7x28	Shared	3.33333	2.77778	No	No	No	No	1	2
321	4x34	4x37	Shared	10	3.33333	No	No	No	No	0	0
322	4x69	E2	Shared	4	4.16667	No	No	Yes	Yes	0	3
323	6x23	I3	Shared	1.66667	0	No	Yes	Yes	Yes	0	0
324	2x39	3x49	amine_on	0	100	No	No	Yes	Yes	8	9
325	2x46	2x50	amine_on	0	100	No	Yes	Yes	Yes	9	9
326	2x46	3x43	amine_on	0	100	No	Yes	No	No	9	8
327	2x46	7x49	amine_on	0	100	No	Yes	Yes	Yes	9	9
328	3x40	6x48	amine_on	0	100	No	No	Yes	Yes	8	8
329	3x43	7x49	amine_on	0	100	No	No	Yes	Yes	8	9
330	3x43	7x53	amine_on	0	100	No	No	Yes	Yes	8	9
331	3x46	3x50	amine_on	0	100	No	Yes	Yes	No	9	9
332	3x46	7x53	amine_on	0	100	No	Yes	Yes	Yes	9	9
333	3x47	5x58	amine_on	0	100	No	No	Yes	Yes	9	9
334	3x50	5x58	amine_on	0	100	Yes	No	Yes	Yes	9	9
335	3x50	7x53	amine_on	0	100	Yes	No	Yes	Yes	9	9
336	4x60	5x39	amine_on	0	100	No	No	Yes	No	7	7
337	5x37	6x60	amine_on	0	100	No	No	No	No	4	4
338	5x44	6x56	amine_on	0	100	No	No	No	No	6	5
339	5x47	6x44	amine_on	0	100	No	Yes	Yes	Yes	8	9
340	5x47	6x48	amine_on	0	100	No	Yes	Yes	Yes	8	8
341	5x47	6x49	amine_on	0	100	No	Yes	No	Yes	8	6
342	5x51	6x44	amine_on	0	100	No	No	Yes	Yes	6	9
343	5x54	6x44	amine_on	0	100	No	No	Yes	Yes	8	9
344	5x58	6x37	amine_on	0	100	Yes	Yes	No	No	9	8
345	5x58	6x40	amine_on	0	100	Yes	Yes	No	No	9	8
346	5x62	6x34	amine_on	0	100	No	Yes	No	No	5	7
347	6x40	7x53	amine_on	0	100	No	No	Yes	Yes	8	9
348	7x52	7x53	amine_on	0	100	No	No	Yes	Yes	8	9
349	7x54	8x50	amine_on	0	100	No	No	Yes	Yes	7	8
350	E2	E3	amine_on	0	100	Yes	Yes	No	Yes	3	3
351	5x55	6x41	amine_on	0	60.2778	No	No	No	No	5	8
352	3x29	E2x52	amine_on	0	64.7685	No	No	No	No	5	4
353	E1x51	E1x52	amine_on	0	61.2269	No	No	No	No	3	5
354	5x66	6x30	amine_on	0	67.1296	No	No	No	No	6	8
355	3x44	5x50	amine_on	0	65.2006	No	No	No	No	6	9
356	2x54	2x57	amine_on	0	54.0895	No	No	Yes	Yes	6	8
357	1x53	7x54	amine_on	0	55.5556	No	No	No	No	9	7
358	3x41	4x49	amine_on	0	59.6296	No	No	No	No	6	6
359	6x43	7x52	amine_on	0	56.5741	No	No	No	No	6	8
360	I2x52	I2x56	amine_on	0	57.2685	No	Yes	No	No	5	4
361	2x60	2x64	amine_on	0	52.7778	Yes	Yes	No	No	7	5
362	5x40	6x59	amine_on	0	48.6111	No	No	No	No	6	5
363	4x61	E2	amine_on	0	48.8426	No	No	Yes	Yes	6	3
364	6x45	6x49	amine_on	0	40.6944	No	No	No	Yes	6	6
365	5x41	6x56	amine_on	0	28.1481	No	No	No	No	6	5
366	7x30	E3	amine_on	0	51.1343	No	Yes	No	Yes	4	3
367	2x41	4x42	amine_on	0	56.4815	No	No	No	No	4	7
368	1x42	7x39	amine_on	0	39.3519	No	No	Yes	No	7	6
369	3x37	4x56	amine_on	0	49.4676	No	No	No	No	7	6
370	1x50	2x47	amine_on	0	44.2824	No	Yes	No	No	9	9
371	5x37	6x59	amine_on	0	30.463	No	No	No	No	4	5
372	5x65	6x33	amine_on	0	30.7253	No	No	No	No	8	8
373	6x43	7x48	amine_on	0	21.9444	No	No	No	No	6	6
374	5x62	6x37	amine_on	0	35.463	No	Yes	No	No	5	8
375	1x57	8x50	amine_on	0	39.1435	No	No	Yes	Yes	7	8
376	1x59	1x60	amine_on	0	27.6389	No	No	Yes	Yes	5	6
377	7x55	8x54	amine_on	0	25.6019	No	No	Yes	Yes	5	6
378	4x47	4x51	amine_on	0	16.6667	No	No	No	No	2	4
379	2x43	3x46	amine_on	0	27.0525	No	No	No	Yes	8	9
380	2x62	2x66	amine_on	0	29.9769	No	No	No	No	4	4
381	5x69	6x30	amine_on	0	27.3148	No	No	No	No	5	8
382	3x21	3x24	amine_on	0	20.4475	No	No	No	No	7	5
383	I2x53	I2x54	amine_on	0	17.5926	Yes	Yes	No	No	7	6
384	8x52	8x55	amine_on	0	21.6204	No	No	No	No	4	3
385	8x47	8x48	amine_on	0	15.0463	No	No	No	No	9	5
386	4x48	4x52	amine_on	0	9.10494	No	No	No	No	2	5
387	6x31	6x34	amine_on	0	23.6111	No	No	No	No	5	7
388	1x36	2x61	amine_on	0	25	No	No	No	No	6	6
389	5x69	6x26	amine_on	0	33.4105	No	No	No	No	5	5
390	7x30	7x31	amine_on	0	8.47222	No	Yes	No	No	4	2
391	5x62	6x33	amine_on	0	11.5278	No	Yes	No	No	5	8
392	5x70	5x71	amine_on	0	20.8333	No	No	No	No	0	0
393	5x67	5x71	amine_on	0	17.9167	No	No	No	No	5	0
394	5x66	5x70	amine_on	0	19.4444	No	No	No	No	6	0
395	1x30	1x31	amine_on	0	23.287	No	No	No	Yes	1	3
396	1x38	1x42	amine_on	0	15.0926	No	No	No	No	4	7
397	1x54	1x58	amine_on	0	10.4167	No	No	No	No	6	1
398	6x29	6x32	amine_on	0	11.4583	No	No	No	No	6	8
399	4x39	4x43	amine_on	0	7.40741	No	No	No	No	4	4
400	5x68	6x30	amine_on	0	22.7778	No	No	No	No	7	8
401	5x74	I3	amine_on	0	17.5926	No	No	Yes	Yes	0	0
402	5x69	6x29	amine_on	0	12.037	No	No	No	No	5	6
403	I2x51	I2x52	amine_on	0	7.93982	No	No	No	Yes	7	5
404	5x62	5x63	amine_on	0	2.22222	No	Yes	No	No	5	4
405	1x37	1x41	amine_on	0	8.33333	No	No	No	No	4	4
406	5x70	5x74	amine_on	0	16.6667	No	No	No	No	0	0
407	4x64	4x68	amine_on	0	16.6667	No	No	No	No	4	4
408	6x27	6x31	amine_on	0	11.1111	No	No	No	No	5	5
409	3x23	3x26	amine_on	0	5.64815	No	No	No	No	1	6
410	5x73	6x28	amine_on	0	16.6667	No	No	No	No	0	6
411	5x68	5x72	amine_on	0	9.81481	No	No	No	No	7	0
412	1x30	NT	amine_on	0	7.40741	No	No	Yes	No	1	0
413	I2x52	I2x55	amine_on	0	9.44444	No	Yes	No	No	5	4
414	5x51	5x52	amine_on	0	3.33333	No	No	No	No	6	3
415	1x60	CT	amine_on	0	4.16667	Yes	Yes	No	No	6	3
416	4x51	4x52	amine_on	0	5.55556	No	No	No	No	4	5
417	E1	E1x49	amine_on	0	5.09259	No	No	No	No	3	4
418	5x74	5x75	amine_on	0	5.55556	No	No	No	No	0	0
419	8x58	8x59	amine_on	0	5.55556	No	No	No	No	6	4
420	5x72	5x76	amine_on	0	1.11111	No	No	No	No	0	0
421	2x66	2x67	amine_on	0	0	No	No	No	No	4	5
422	6x24	I3	amine_on	0	4.16667	No	No	Yes	Yes	0	0
423	4x67	4x68	amine_on	0	5	No	No	No	No	6	4
424	6x22	6x23	amine_on	0	4.16667	No	No	No	Yes	0	0
425	4x40	I2	amine_on	0	3.33333	No	No	No	No	5	0
426	8x61	8x62	amine_on	0	2.77778	No	No	No	No	0	0
427	6x34	6x38	amine_on	0	1.04167	No	No	No	No	7	6
428	2x38	I2x58	amine_on	0	4.16667	No	No	No	No	5	0
429	5x77	5x78	amine_on	0	1.85185	No	No	No	No	0	0
430	I1x49	I1x52	amine_on	0	2.77778	No	No	No	No	6	0
431	5x73	5x77	amine_on	0	1.85185	No	No	No	No	0	0
432	8x56	8x60	amine_on	0	2.77778	No	No	No	No	4	8
433	4x35	I2x54	amine_on	0	2.77778	No	No	No	No	0	6
434	5x80	I3	amine_on	0	1.85185	No	No	Yes	Yes	0	0
435	5x79	5x80	amine_on	0	1.85185	No	No	No	No	0	0
436	5x77	5x81	amine_on	0	0.37037	No	No	No	No	0	0
437	6x14	6x16	amine_on	0	0.694444	No	No	No	No	0	0
438	2x67	2x68	amine_on	0	0	No	No	No	No	5	0
439	4x36	4x37	amine_on	0	0.925926	No	No	No	No	0	0
440	1x26	1x31	amine_on	0	1.04167	No	No	No	Yes	0	3
441	6x20	6x23	amine_on	0	0.694444	No	No	No	Yes	0	0
442	8x60	8x61	amine_on	0	0.37037	No	No	No	No	8	0
443	4x37	4x41	amine_on	0	0	No	No	No	No	0	6
444	5x80	5x84	amine_on	0	0	No	No	No	No	0	0
445	6x19	6x23	amine_on	0	0.308642	No	No	No	Yes	0	0
446	6x14	6x17	amine_on	0	0.308642	No	No	No	No	0	0
447	1x27	1x31	amine_on	0	0	No	No	No	Yes	2	3
448	5x83	5x86	amine_on	0	0	No	No	No	No	0	0
449	6x18	6x22	amine_on	0	0.0771605	No	No	No	No	0	0
450	6x14	6x15	amine_on	0	0.0771605	No	No	No	No	0	0
451	6x16	6x20	amine_on	0	0.0771605	No	No	No	No	0	0
452	6x21	6x24	amine_on	0	0	No	No	No	No	0	0

Orange: nodes, hubs and links specific of amine_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of amine_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	amine_off Avg Int. Strength	amine_on Avg Int. Strength	amine_off Num Of Links	amine_on Num Of Links	ConSurf
1	1x35	amine_off	0	0	4	1	3
2	I1x50	amine_off	22.6667	6.71296	4	3	8
3	2x56	amine_off	16.6667	0	4	3	8
4	3x50	amine_off	28	0	6	3	9
5	3x56	amine_off	0	0	4	3	6
6	I2x57	amine_off	26.6667	16.6667	4	3	6
7	5x36	amine_off	0	0	4	2	5
8	5x39	amine_off	0	17.1296	4	3	7
9	6x55	amine_off	10	11.5278	4	3	7
10	7x34	amine_off	20	0	4	1	3
11	7x39	amine_off	58.6667	21.7593	5	3	6
12	7x45	amine_off	29.3333	0	5	3	9
13	NT	amine_off	16.6667	0	6	2	0
14	1x60	Shared	0	3.7037	4	6	6
15	2x42	Shared	38.1905	31.5278	5	4	8
16	2x50	Shared	40.6667	71.2654	5	5	9
17	2x57	Shared	45.3333	15.2778	5	4	8
18	2x60	Shared	20	31.1806	4	4	7
19	E1x50	Shared	93.3333	85.8333	5	5	7
20	3x28	Shared	33.6667	35.8796	5	4	5
21	3x49	Shared	41.1905	9.02778	4	4	9
22	3x51	Shared	16	22.9167	4	4	8
23	I2x53	Shared	35.6667	27.1296	4	5	7
24	E2	Shared	100	91.5124	16	15	3
25	5x58	Shared	0	72.9861	4	5	9
26	6x44	Shared	90.6667	50	4	5	9
27	6x48	Shared	99.2857	97.2222	7	8	8
28	6x51	Shared	79.2857	74.8611	6	4	7
29	6x52	Shared	45.2857	55.0463	5	5	7
30	7x38	Shared	22.6667	23.9583	4	4	6
31	7x42	Shared	100	95.1389	7	7	7
32	7x49	Shared	0	30.4475	4	4	9
33	7x53	Shared	29.1667	81.2191	4	5	9
34	8x50	Shared	68.6667	54.1667	5	6	8
35	8x54	Shared	6.66667	0	4	4	6
36	Lig	Shared	100	100	12	12	0
37	I3	Shared	5	0	5	4	0
38	1x31	amine_on	0	0	2	4	3
39	1x50	amine_on	16.6667	7.63889	3	4	9
40	2x46	amine_on	0	25.679	2	4	9
41	3x46	amine_on	0	0	1	4	9
42	I2x52	amine_on	0	0	1	4	5
43	5x47	amine_on	20	83.6574	3	6	8
44	5x62	amine_on	0	0	2	5	5
45	6x23	amine_on	0	0	1	4	0
46	6x49	amine_on	0	0	2	4	6
47	E3	amine_on	50.119	46.7361	3	5	3
48	7x30	amine_on	0	0	2	4	4

Orange: nodes, hubs and links specific of amine_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of amine_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	amine_off Recurrence	amine_on Recurrence	amine_off Hub1?	amine_on Hub1?	amine_off Hub2?	amine_on Hub2?	ConSurf1	ConSurf2
1	2x53	2x56	amine_off	36.263	0	No	No	Yes	No	7	8
2	2x53	7x46	amine_off	34.6111	6.51764	No	No	No	No	7	9
3	2x50	7x46	amine_off	34.3699	8.67762	Yes	Yes	No	No	9	9
4	7x49	7x53	amine_off	56.6626	0	Yes	Yes	Yes	Yes	9	9
5	7x53	8x50	amine_off	46.2636	0	Yes	Yes	Yes	Yes	9	8
6	1x53	7x53	amine_off	10.8081	0	No	No	Yes	Yes	9	9
7	8x49	I1x50	amine_off	12.2083	0	No	No	Yes	No	6	8
8	8x47	8x49	amine_off	11.9041	2.17712	No	No	No	No	9	6
9	2x50	3x39	amine_off	100	2.17712	Yes	Yes	No	No	9	9
10	2x46	3x39	amine_off	99.3392	0	No	Yes	No	No	9	9
11	2x45	3x42	amine_off	97.294	7.38506	No	No	No	No	9	8
12	2x45	4x46	amine_off	94.4203	1.48798	No	No	No	No	9	8
13	2x42	4x46	amine_off	93.6756	0	Yes	Yes	No	No	8	8
14	3x49	3x50	amine_off	12.7222	0	Yes	Yes	Yes	No	9	9
15	3x49	I2x57	amine_off	12.1821	6.44564	Yes	Yes	Yes	No	9	6
16	2x38	I2x57	amine_off	12.2555	5.45137	No	No	Yes	No	5	6
17	2x38	4x39	amine_off	10.8186	2.9314	No	No	No	No	5	4
18	2x42	3x45	amine_off	18.3387	2.9314	Yes	Yes	No	No	8	7
19	5x43	Lig	amine_off	13.9389	4.41595	No	No	Yes	Yes	6	0
20	5x39	5x43	amine_off	12.7956	3.63082	Yes	No	No	No	7	6
21	3x40	6x44	amine_off	18.454	0.380567	No	No	Yes	Yes	8	9
22	3x40	5x50	amine_off	16.6553	0	No	No	No	No	8	9
23	3x41	5x50	amine_off	13.0264	5.92108	No	No	No	No	6	9
24	3x49	I2x53	amine_off	60.3125	8.24219	Yes	Yes	Yes	Yes	9	7
25	3x52	I2x53	amine_off	60.7006	2.9314	No	No	Yes	Yes	5	7
26	3x48	3x52	amine_off	59.5574	1.46741	No	No	No	No	6	5
27	3x48	5x57	amine_off	58.3827	0	No	No	No	No	6	5
28	5x47	6x52	amine_off	17.9401	9.47303	No	Yes	Yes	Yes	8	7
29	5x47	5x48	amine_off	10.6823	3.82967	No	Yes	No	No	8	5
30	5x54	6x41	amine_off	21.6005	0	No	No	No	No	8	8
31	5x58	6x41	amine_off	17.0539	7.71763	Yes	Yes	No	No	9	8
32	6x40	7x49	amine_off	12.8743	0	No	No	Yes	Yes	8	9
33	6x51	7x38	amine_off	10.5302	1.67655	Yes	Yes	Yes	Yes	7	6
34	6x51	7x34	amine_off	32.8491	0	Yes	Yes	Yes	No	7	3
35	6x54	7x34	amine_off	28.9423	0	No	No	Yes	No	5	3
36	6x54	7x37	amine_off	26.5929	1.91655	No	No	No	No	5	5
37	6x50	7x37	amine_off	12.266	3.82967	No	No	No	No	9	5
38	6x55	Lig	amine_off	10.2627	6.01707	Yes	No	Yes	Yes	7	0
39	6x58	7x34	amine_off	10.8343	1.2857	No	No	Yes	No	4	3
40	3x41	4x52	amine_off	11.1962	7.38506	No	No	No	No	6	5
41	1x35	1x39	amine_off	25.4916	0	Yes	No	No	No	3	6
42	1x35	2x65	amine_off	16.0627	1.15884	Yes	No	No	No	3	5
43	1x32	2x65	amine_off	12.7851	7.15878	No	No	No	No	6	5
44	1x32	NT	amine_off	11.4217	6.02393	No	No	Yes	No	6	0
45	3x45	4x45	amine_off	16.8913	1.46741	No	No	No	No	7	6
46	3x51	5x61	amine_off	18.3177	6.36336	Yes	Yes	No	No	8	9
47	7x33	7x37	amine_off	12.2817	0	No	No	No	No	4	5
48	6x40	7x52	amine_off	11.3011	0	No	No	No	No	8	8
49	4x41	4x45	amine_off	15.36	0	No	No	No	No	6	6
50	8x48	8x49	amine_off	21.0341	0	No	No	No	No	5	6
51	8x48	8x51	amine_off	14.9405	2.17712	No	No	No	No	5	9
52	3x54	5x61	amine_off	16.7917	4.24452	No	No	No	No	9	9
53	3x54	5x64	amine_off	15.2341	2.12226	No	No	No	No	9	6
54	5x64	5x68	amine_off	11.0231	0	No	No	No	No	6	7
55	8x51	8x55	amine_off	11.8779	0	No	No	No	No	9	3
56	6x44	7x45	amine_off	10.7557	0	Yes	Yes	Yes	No	9	9
57	6x48	6x51	amine_off	21.569	0	Yes	Yes	Yes	Yes	8	7
58	6x48	6x52	amine_off	11.2748	3.26739	Yes	Yes	Yes	Yes	8	7
59	1x39	7x39	Shared	30.2323	13.4878	No	No	Yes	No	6	6
60	7x39	7x42	Shared	32.503	17.7667	Yes	No	Yes	Yes	6	7
61	2x56	7x42	Shared	28.8269	16.2992	Yes	No	Yes	Yes	8	7
62	1x50	2x50	Shared	22.0934	95.7623	No	Yes	Yes	Yes	9	9
63	7x42	Lig	Shared	37.8677	56.3891	Yes	Yes	Yes	Yes	7	0
64	6x48	Lig	Shared	52.2681	100	Yes	Yes	Yes	Yes	8	0
65	6x48	7x45	Shared	74.6762	69.8015	Yes	Yes	Yes	No	8	9
66	7x45	7x49	Shared	85.1696	69.4929	Yes	No	Yes	Yes	9	9
67	8x50	8x54	Shared	11.9251	17.5952	Yes	Yes	Yes	Yes	8	6
68	8x50	I1x50	Shared	19.0152	22.6352	Yes	Yes	Yes	No	8	8
69	8x47	8x50	Shared	13.383	12.977	No	No	Yes	Yes	9	8
70	2x46	3x42	Shared	98.668	24.418	No	Yes	No	No	9	8
71	2x42	3x49	Shared	81.0058	17.4889	Yes	Yes	Yes	Yes	8	9
72	1x50	2x51	Shared	14.437	15.1164	No	Yes	No	No	9	7
73	1x47	2x51	Shared	11.3011	10.8307	No	No	No	No	5	7
74	2x60	3x28	Shared	12.6173	31.0179	Yes	Yes	Yes	Yes	7	5
75	3x28	E1x50	Shared	16.6291	53.7045	Yes	Yes	Yes	Yes	5	7
76	E2x52	Lig	Shared	30.6309	31.0488	No	No	Yes	Yes	4	0
77	E2	E2x52	Shared	29.4929	29.4065	Yes	Yes	No	No	3	4
78	6x44	6x48	Shared	11.2591	44.0909	Yes	Yes	Yes	Yes	9	8
79	3x47	5x57	Shared	27.4529	43.0109	No	No	No	No	9	5
80	3x47	5x54	Shared	26.0056	47.5606	No	No	No	No	9	8
81	3x51	5x57	Shared	34.3542	41.0258	Yes	Yes	No	No	8	5
82	2x57	7x42	Shared	19.7913	11.3793	Yes	Yes	Yes	Yes	8	7
83	2x56	3x28	Shared	16.1676	29.6705	Yes	No	Yes	Yes	8	5
84	2x50	7x49	Shared	83.502	70.8163	Yes	Yes	Yes	Yes	9	9
85	3x32	Lig	amine_on	6.75442	15.7267	No	No	Yes	Yes	8	0
86	1x39	2x61	amine_on	3.85442	12.6924	No	No	No	No	6	6
87	7x54	8x50	amine_on	0	67.4769	No	No	Yes	Yes	7	8
88	1x53	7x54	amine_on	0	69.4106	No	No	No	No	9	7
89	1x53	2x47	amine_on	9.71734	71.3375	No	No	No	No	9	9
90	1x50	2x47	amine_on	0	73.2574	No	Yes	No	No	9	9
91	1x57	8x50	amine_on	0	10.8136	No	No	Yes	Yes	7	8
92	1x60	I1x50	amine_on	5.91012	20.6261	Yes	Yes	Yes	No	6	8
93	2x42	3x46	amine_on	1.56799	27.0305	Yes	Yes	No	Yes	8	9
94	3x46	7x53	amine_on	0	23.2523	No	Yes	Yes	Yes	9	9
95	3x43	7x53	amine_on	0	94.8709	No	No	Yes	Yes	8	9
96	3x43	7x49	amine_on	0	52.1651	No	No	Yes	Yes	8	9
97	2x46	7x49	amine_on	0	11.2902	No	Yes	Yes	Yes	9	9
98	2x56	3x32	amine_on	6.73344	15.0444	Yes	No	No	No	8	8
99	2x60	7x42	amine_on	5.23887	18.1164	Yes	Yes	Yes	Yes	7	7
100	E1x50	E1x52	amine_on	5.564	38.6396	Yes	Yes	No	No	7	5
101	E1x51	E1x52	amine_on	0	26.5231	No	No	No	No	3	5
102	3x42	4x49	amine_on	1.64141	16.025	No	No	No	No	8	6
103	3x41	4x49	amine_on	0	14.6021	No	No	No	No	6	6
104	5x54	6x44	amine_on	0	48.068	No	No	Yes	Yes	8	9
105	3x47	5x58	amine_on	0	56.1834	No	No	Yes	Yes	9	9
106	3x50	5x58	amine_on	0	40.2613	Yes	No	Yes	Yes	9	9
107	3x51	3x55	amine_on	8.12313	28.9711	Yes	Yes	No	No	8	6
108	3x55	3x56	amine_on	6.51843	26.938	No	No	Yes	No	6	6
109	3x56	I2x52	amine_on	1.64141	22.8512	Yes	No	No	Yes	6	5
110	5x47	6x48	amine_on	0	11.6502	No	Yes	Yes	Yes	8	8
111	5x47	6x49	amine_on	0	15.1644	No	Yes	No	Yes	8	6
112	5x58	6x37	amine_on	0	70.59	Yes	Yes	No	No	9	8
113	5x58	6x40	amine_on	0	34.1928	Yes	Yes	No	No	9	8
114	6x40	7x53	amine_on	0	34.4225	No	No	Yes	Yes	8	9
115	5x62	6x37	amine_on	0	68.8552	No	Yes	No	No	5	8
116	5x62	5x66	amine_on	5.564	46.4395	No	Yes	No	No	5	6
117	5x62	6x34	amine_on	0	14.6844	No	Yes	No	No	5	7
118	E2	E3	amine_on	0	11.0124	Yes	Yes	No	Yes	3	3
119	I2x52	I2x56	amine_on	0	16.6695	No	Yes	No	No	5	4
120	4x41	I2x56	amine_on	4.04846	14.5815	No	No	No	No	6	4
121	2x66	E1x51	amine_on	1.88788	15.3358	No	No	No	No	4	3
122	1x36	2x61	amine_on	0	10.5085	No	No	No	No	6	6
123	5x66	6x30	amine_on	0	14.7393	No	No	No	No	6	8
124	6x31	6x34	amine_on	0	10.9919	No	No	No	No	5	7
125	5x66	5x70	amine_on	0	30.3528	No	No	No	No	6	0
126	2x60	7x38	amine_on	9.38696	18.1609	Yes	Yes	Yes	Yes	7	6
127	7x38	Lig	amine_on	5.00813	17.4889	Yes	Yes	Yes	Yes	6	0
128	3x50	7x53	amine_on	0	33.9493	Yes	No	Yes	Yes	9	9
129	5x70	5x74	amine_on	0	25.4706	No	No	No	No	0	0
130	5x74	I3	amine_on	0	22.474	No	No	Yes	Yes	0	0
131	6x23	I3	amine_on	1.15895	13.4844	No	Yes	Yes	Yes	0	0
132	2x46	2x50	amine_on	0	35.8247	No	Yes	Yes	Yes	9	9
133	2x46	3x43	amine_on	0	43.2921	No	Yes	No	No	9	8

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
2x56	3x32	Shared	8.13011	7.97594	1	1	2	1
2x56	7x42	Shared	4.93137	3.88703	1	1	2	1
2x57	7x39	amine_off	4.41859	0	1	0	2	2
2x57	7x42	Shared	6.09801	6.46597	1	0	2	1
2x60	7x39	amine_off	4.75098	0	1	1	2	2
2x60	7x42	Shared	4.31903	4.85844	1	1	2	1
3x32	7x42	Shared	8.1011	9.00539	1	1	1	1
3x32	Lig	Shared	13.6262	12.3911	1	1	1	0
3x33	4x57	Shared	7.04991	7.03242	0	0	1	2
3x33	Lig	Shared	11.5319	11.1621	0	0	1	0
3x36	6x48	Shared	4.94759	4.5365	1	1	1	1
3x36	Lig	Shared	8.02636	7.8178	1	1	1	0
3x37	4x57	amine_off	4.12839	0	0	0	2	2
3x37	5x461	Shared	5.97156	5.41446	0	0	2	1
3x40	6x44	Shared	6.20277	3.59117	0	1	2	2
E2	E2	Shared	42.0055	48.4232	1	1	2	2
5x39	E2	Shared	6.2431	6.39511	1	1	2	2
E2x52	Lig	Shared	3.93874	3.53891	1	1	1	0
5x40	6x55	Shared	5.06311	3.52373	0	0	2	1
5x43	Lig	Shared	3.97104	3.81639	0	0	1	0
5x461	Lig	Shared	4.10686	3.43582	0	0	1	0
5x47	6x52	Shared	26.3546	18.6109	0	1	2	1
6x44	6x48	Shared	10.2071	4.97529	1	1	2	1
6x44	7x45	amine_off	6.99236	0	1	1	2	2
6x48	6x51	amine_off	5.09179	0	1	1	1	1
6x48	6x52	Shared	3.57309	5.04786	1	1	1	1
6x48	7x41	Shared	11.7787	8.00332	1	1	1	2
6x48	7x45	Shared	3.75229	9.74538	1	1	1	2
6x48	Lig	Shared	10.3287	3.93769	1	1	1	0
6x51	6x52	Shared	5.58631	5.34818	1	1	1	1
6x51	6x55	Shared	6.66296	6.07262	1	1	1	1
6x51	7x34	amine_off	5.15641	0	1	1	1	2
6x51	7x38	Shared	6.27234	5.62684	1	1	1	1
6x51	Lig	Shared	12.2207	12.5075	1	1	1	0
6x52	Lig	Shared	11.5362	5.56849	1	1	1	0
6x55	7x34	amine_off	4.07629	0	1	1	1	2
6x55	Lig	Shared	4.46175	3.59644	1	1	1	0
7x38	7x42	Shared	5.3912	6.78735	1	1	1	1
7x38	Lig	Shared	9.11717	8.08708	1	1	1	0
7x39	7x42	Shared	7.25976	7.71662	1	0	2	1
7x42	Lig	Shared	4.81398	5.78002	1	1	1	0
E2	E2x52	Shared	8.37453	5.76779	1	1	2	1
5x39	5x43	Shared	4.18421	5.67246	1	1	2	1
2x60	7x38	Shared	4.17907	3.55067	1	1	2	1
5x44	6x52	Shared	2.8712	3.61335	0	0	2	1
3x40	6x48	amine_on	0	8.03967	0	1	2	1
5x47	6x44	amine_on	0	4.84897	0	1	2	2
5x47	6x48	amine_on	0	3.74614	0	1	2	1
3x29	E2x52	amine_on	0	3.31722	0	0	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	amine_off	5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
	amine_on	5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on

Network Difference
Value	amine_off	amine_on
I_min	3.51218	3.33778
Number of Linked Nodes	298	313
Number of Specific Nodes	4 (1.34%)	19 (6.07%)
Number of Shared Nodes	294 (98.66%)	294 (93.93%)
Number of Links	323	334
Number of Specific Links	118 (36.53%)	129 (38.62%)
Number of Shared Links	205 (63.47%)	205 (61.38%)
Number of Hubs	37	35
Number of Specific Hubs	13 (35.14%)	11 (31.43%)
Number of Shared Hubs	24 (64.86%)	24 (68.57%)
Average % Shared Neighbours (Jaccard)	49.47
Average % Shared Neighbours (Otsuka)	57.04
Average % Shared Neighbours (Overlap Coefficient)	65.07
Average % Shared Cliques (k3-6)	61.54
Graphlets Similarity	0.59276

Paths Difference
Value	amine_off	amine_on
Number Of Nodes in MetaPath	82	69
Specific Nodes in MetaPath	42 (51.22%)	29 (42.03%)
Shared Nodes in MetaPath	294 (98.66%)	294 (98.66%)
Number Of Links MetaPath	84	75
Specific Links in MetaPath	58 (69.05%)	49 (65.33%)
Shared Links in MetaPath	205 (63.47%)	205 (63.47%)
Number of Shortest Paths	49697	77001
Length Of Smallest Path	3	3
Average Path Length	13.6424	13.6728
Length of Longest Path	33	28
Minimum Path Strength	0.456802	0.195727
Average Path Strength	4.9939	4.78096
Maximum Path Strength	18.9454	12.4493
Minimum Path Correlation	0.700662	0.70031
Average Path Correlation	0.900564	0.906288
Maximum Path Correlation	0.988817	0.988222
Minimum % Of Corr. Nodes	3.33333	4.16667
Average % Of Corr. Nodes	41.0779	39.4193
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	43.7246	44.4496
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

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