Orange: nodes, hubs and links specific of amine_on_gp network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of amine_off network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.


Index Hub Owner amine_on_gp Avg Int. Strength amine_off Avg Int. Strength amine_on_gp Num Of Links amine_off Num Of Links ConSurf
1G.hns1.03 amine_on_gp00404
2G.S1.06 amine_on_gp5.833330408
3G.S2.06 amine_on_gp4.166670503
4G.S2.08 amine_on_gp25.92590403
5G.S3.03 amine_on_gp68.54170604
6G.S3.04 amine_on_gp52.83950407
7G.S3.05 amine_on_gp17.59260406
8G.S3.06 amine_on_gp78.77320507
9G.H2.06 amine_on_gp96.68210708
10G.H2.07 amine_on_gp86.57410509
11G.h2s4.01 amine_on_gp78.27930507
12G.s4h3.04 amine_on_gp39.82250608
13G.H3.01 amine_on_gp10.27780609
14G.H3.03 amine_on_gp00408
15G.H3.06 amine_on_gp15.37040409
16G.H3.09 amine_on_gp96.9290709
17G.H3.13 amine_on_gp53.88890508
18G.H3.14 amine_on_gp00405
19G.H3.17 amine_on_gp86.57410704
20G.H3.18 amine_on_gp28.65740405
21G.S5.04 amine_on_gp35.4630408
22G.S5.05 amine_on_gp79.8380609
23G.S5.07 amine_on_gp16.29630508
24G.HG.01 amine_on_gp11.11110409
25G.HG.03 amine_on_gp00409
26G.hgh4.01 amine_on_gp12.9630403
27G.hgh4.02 amine_on_gp48.65740506
28G.hgh4.05 amine_on_gp58.89660606
29G.H4.05 amine_on_gp00404
30G.H4.08 amine_on_gp11.11110405
31G.H4.10 amine_on_gp44.5370403
32G.H4.12 amine_on_gp29.5370407
33G.H4.13 amine_on_gp00405
34G.H4.14 amine_on_gp12.59260403
35G.H4.15 amine_on_gp73.13270405
36G.H4.16 amine_on_gp00408
37G.S6.02 amine_on_gp92.45370605
38G.S6.05 amine_on_gp47.61570509
39G.s6h5.01 amine_on_gp37.26850404
40G.H5.03 amine_on_gp27.9630404
41G.H5.08 amine_on_gp85.69440608
42G.H5.13 amine_on_gp19.02780406
43G.H5.17 amine_on_gp40.50930506
44G.H5.20 amine_on_gp8.333330408
45G.H5.25 amine_on_gp4.166670408
46G.H5.26 amine_on_gp0.8487650407
47b.h2x1 amine_on_gp10.55560405
48b.lhb1x3 amine_on_gp6.666670502
49b.lhb1x6 amine_on_gp00403
50b.l1x3 amine_on_gp1000609
51b.l1x6 amine_on_gp26.38890509
52b.b2x1 amine_on_gp64.10490508
53b.b2x5 amine_on_gp95.92590607
54b.b3x3 amine_on_gp35.58640508
55b.l3x1 amine_on_gp27.77780409
56b.l3x2 amine_on_gp56.13430509
57b.b4x3 amine_on_gp25.1620407
58b.b4x6 amine_on_gp1000609
59b.l4x2 amine_on_gp10.41670404
60b.b5x2 amine_on_gp5.555560507
61b.b5x3 amine_on_gp93.61110609
62b.b5x5 amine_on_gp18.1250405
63b.b5x7 amine_on_gp46.75930407
64b.l5x1 amine_on_gp72.65430508
65b.l5x5 amine_on_gp1000609
66b.b6x5 amine_on_gp77.24540606
67b.l6x5 amine_on_gp48.91980404
68b.b7x1 amine_on_gp58.82720404
69b.l7x4 amine_on_gp50409
70b.b8x3 amine_on_gp29.05090506
71b.b8x4 amine_on_gp96.29630506
72b.l9x3 amine_on_gp90.97220609
73b.l9x6 amine_on_gp1000908
74b.b10x5 amine_on_gp47.52320609
75b.b11x4 amine_on_gp51.20370409
76b.l11x2 amine_on_gp85.20060409
77b.b12x6 amine_on_gp1000708
78b.l12x1 amine_on_gp00406
79b.b13x7 amine_on_gp96.48150507
80b.l13x3 amine_on_gp99.30560609
81b.l13x6 amine_on_gp56.45830509
82b.l13x7 amine_on_gp44.98460409
83b.b14x3 amine_on_gp46.74380405
84b.b15x1 amine_on_gp79.83020509
85b.l15x1 amine_on_gp51.55090407
86b.l15x2 amine_on_gp65.97220509
87b.b16x4 amine_on_gp93.22530406
88b.b16x6 amine_on_gp1000608
89b.b17x5 amine_on_gp58.93520407
90b.b17x7 amine_on_gp83.47220408
91b.l17x3 amine_on_gp97.91670609
92b.l17x6 amine_on_gp64.97680409
93b.b18x3 amine_on_gp81.65120408
94b.b18x5 amine_on_gp23.61110405
95b.l18x1 amine_on_gp95.09260706
96b.l18x2 amine_on_gp40.6250407
97b.b19x2 amine_on_gp94.69140606
98b.b19x4 amine_on_gp73.20220408
99b.l19x1 amine_on_gp6.944440409
100b.l19x2 amine_on_gp74.12810509
101b.b20x4 amine_on_gp1000508
102b.b20x6 amine_on_gp95.38580506
103b.b20x7 amine_on_gp24.02780409
104b.l20x2 amine_on_gp21.38890409
105b.b21x1 amine_on_gp64.56020407
106b.b21x5 amine_on_gp00404
107b.b21x7 amine_on_gp93.25620605
108b.l21x2 amine_on_gp00404
109b.b22x5 amine_on_gp52.83950507
110b.l22x5 amine_on_gp76.56640609
111b.b23x1 amine_on_gp11.57410405
112b.b23x6 amine_on_gp1000607
113b.l23x1 amine_on_gp29.90740506
114b.l23x2 amine_on_gp8.333330408
115b.b24x4 amine_on_gp57.85490406
116b.b24x6 amine_on_gp46.29630408
117b.l24x3 amine_on_gp6.666670405
118b.l25x3 amine_on_gp95.77160509
119b.l25x6 amine_on_gp52.29170408
120b.l27x1 amine_on_gp1000809
121b.l27x2 amine_on_gp76.15740409
122b.b28x3 amine_on_gp16.66670407
123b.b28x4 amine_on_gp88.45680406
124b.b28x6 amine_on_gp1000509
125g.h1x8 amine_on_gp00407
126g.l1x4 amine_on_gp5.185180408
127g.h2x11 amine_on_gp56.15740406
128g.ctx3 amine_on_gp90.4090609
129g.ctx6 amine_on_gp19.90740506
130g.ctx14 amine_on_gp15.97220409
131g.ctx15 amine_on_gp44.16670409
132g.ctx16 amine_on_gp1000808
1331x31 amine_on_gp00424
1341x46 amine_on_gp12.50438
1351x50 amine_on_gp34.305616.6667439
1362x46 amine_on_gp57.43830429
1373x24 amine_on_gp06.66667426
1383x37 amine_on_gp22.638913.3333538
1393x41 amine_on_gp00427
1403x42 amine_on_gp34.259316.6667438
1413x43 amine_on_gp10.55560418
1423x46 amine_on_gp2.777780419
143I2x51 amine_on_gp22.50416
1444x50 amine_on_gp16.38890439
1455x47 amine_on_gp93.28720638
1465x50 amine_on_gp22.0370439
1475x62 amine_on_gp00426
1486x23 amine_on_gp00414
1496x49 amine_on_gp4.166670427
150E3 amine_on_gp50.401250.119634
1517x30 amine_on_gp00427
152G.hgh4.13 amine_on_gp00400
153Lig Shared10010013120
1541x60 Shared7.407410547
155I1x50 Shared14.074122.6667448
1562x42 Shared55.208338.1905658
1572x50 Shared73.580340.6667559
1582x56 Shared19.444416.6667448
1592x57 Shared38.495445.3333558
1602x60 Shared34.444420547
161E1x50 Shared89.444493.3333659
1623x28 Shared51.064833.6667456
1633x49 Shared15.277841.1905449
1643x50 Shared34.83828469
165I2x53 Shared58.101935.6667548
166E2 Shared94.290110015164
1675x39 Shared18.61110448
1685x58 Shared84.3750649
1696x44 Shared68.425990.6667649
1706x48 Shared10099.2857878
1716x51 Shared85.185279.2857468
1726x52 Shared65.046345.2857557
1737x38 Shared29.166722.6667447
1747x39 Shared57.33858.6667558
1757x42 Shared95.1389100778
1767x49 Shared44.67590449
1777x53 Shared94.737629.1667549
1788x50 Shared85.972268.6667658
1798x54 Shared06.66667448
180I3 Shared05450
1811x35 amine_off00145
1823x51 amine_off29.652816349
1833x56 amine_off00247
184I2x57 amine_off16.666726.6667348
1855x36 amine_off00346
1866x55 amine_off13.194410348
1877x34 amine_off020244
1887x45 amine_off7.2916729.3333359
189NT amine_off016.6667260
   
Orange: nodes, hubs and links specific of amine_on_gp network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of amine_off network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Owner amine_on_gp Recurrence amine_off Recurrence amine_on_gp Hub1? amine_off Hub1? amine_on_gp Hub2? amine_off Hub2? ConSurf1 ConSurf2
1b.l2x5 b.l4x2 amine_on_gp15.25670NoNoYesNo54
2b.l4x2 g.ctx15 amine_on_gp15.43030YesNoYesNo49
3b.l26x5 g.ctx15 amine_on_gp19.46450NoNoYesNo59
4b.l26x5 g.ctx4 amine_on_gp23.91460NoNoNoNo57
5g.ctx3 g.ctx4 amine_on_gp24.03680YesNoNoNo97
6g.ctx3 g.ctx5 amine_on_gp25.35150YesNoNoNo99
7b.lhb1x11 g.ctx5 amine_on_gp25.59460NoNoNoNo49
8b.b25x7 b.lhb1x11 amine_on_gp25.71380NoNoNoNo74
9b.b25x7 b.b28x6 amine_on_gp26.07210NoNoYesNo79
10b.b27x3 b.b28x6 amine_on_gp26.69260NoNoYesNo89
11b.b26x3 b.b27x3 amine_on_gp32.35190NoNoNoNo68
12b.b22x2 b.b26x3 amine_on_gp34.52930NoNoNoNo86
13b.b22x1 b.b22x2 amine_on_gp34.64860NoNoNoNo88
14b.b22x1 b.l25x6 amine_on_gp34.70130NoNoYesNo88
15b.l25x6 b.l27x1 amine_on_gp46.86620YesNoYesNo89
16b.l1x6 b.l27x1 amine_on_gp29.82260YesNoYesNo99
17b.l1x6 b.l3x1 amine_on_gp36.150YesNoYesNo99
18b.l3x1 b.l5x5 amine_on_gp72.35080YesNoYesNo99
19b.b2x1 b.l27x1 amine_on_gp29.82260YesNoYesNo89
20b.b2x1 b.l3x1 amine_on_gp36.08950YesNoYesNo89
21G.h2s4.01 b.l5x5 amine_on_gp69.04810YesNoYesNo79
22G.H2.07 G.h2s4.01 amine_on_gp76.24320YesNoYesNo97
23G.H2.04 G.H2.07 amine_on_gp96.13040NoNoYesNo99
24G.H2.04 G.H3.08 amine_on_gp96.21160NoNoNoNo95
25G.H3.08 G.S4.04 amine_on_gp96.25620NoNoNoNo57
26G.H3.09 G.S4.04 amine_on_gp95.51890YesNoNoNo97
27G.H3.09 G.S5.04 amine_on_gp94.68310YesNoYesNo98
28G.S5.04 G.S5.06 amine_on_gp96.27270YesNoNoNo89
29G.S5.06 G.S6.05 amine_on_gp98.1040NoNoYesNo99
30G.HG.01 G.S6.05 amine_on_gp98.83880YesNoYesNo99
31G.HG.01 G.s6h5.02 amine_on_gp99.36750YesNoNoNo99
32G.HG.02 G.s6h5.02 amine_on_gp99.40850NoNoNoNo59
33G.HG.02 G.HG.03 amine_on_gp99.44940NoNoYesNo59
34G.HG.03 G.s5hg.01 amine_on_gp99.57210YesNoNoNo99
35G.S5.07 G.s5hg.01 amine_on_gp1000YesNoNoNo89
36G.H1.04 G.S5.07 amine_on_gp50.02140NoNoYesNo98
37G.H1.04 G.S5.05 amine_on_gp50.11730NoNoYesNo99
38G.H5.07 G.S5.05 amine_on_gp20.96660NoNoYesNo39
39G.H5.07 G.S4.03 amine_on_gp20.94480NoNoNoNo38
40G.S1.04 G.S4.03 amine_on_gp20.46610NoNoNoNo78
41G.S1.04 G.S3.03 amine_on_gp20.25040NoNoYesNo74
42G.S5.07 G.s6h5.01 amine_on_gp50.1380YesNoYesNo84
43G.S5.05 G.s6h5.01 amine_on_gp50.14470YesNoYesNo94
44G.H3.17 b.l23x1 amine_on_gp29.90950YesNoYesNo46
45G.H5.08 G.S3.03 amine_on_gp20.02150YesNoYesNo84
46G.H2.06 b.l9x6 amine_on_gp18.5640YesNoYesNo88
47G.H2.06 b.l19x1 amine_on_gp18.2540YesNoYesNo89
48G.H5.10 G.S6.02 amine_on_gp79.40780NoNoYesNo45
49G.H5.10 G.S5.03 amine_on_gp39.72830NoNoNoNo46
50G.S5.03 G.S5.05 amine_on_gp39.76630NoNoYesNo69
51G.H5.10 G.S6.04 amine_on_gp39.7260NoNoNoNo45
52G.S5.05 G.S6.04 amine_on_gp39.7640YesNoNoNo95
53G.H5.13 G.S6.02 amine_on_gp39.49050YesNoYesNo65
54G.H5.17 G.S6.02 amine_on_gp39.37140YesNoYesNo65
55G.H5.08 G.H5.12 amine_on_gp19.83390YesNoNoNo88
565x68 G.H5.13 amine_on_gp39.27910NoNoYesNo76
575x68 G.H5.16 amine_on_gp78.43890NoNoNoNo77
58G.H5.16 I2x50 amine_on_gp78.32630NoNoNoNo78
595x68 G.H5.17 amine_on_gp39.27280NoNoYesNo76
60G.H5.12 I2x50 amine_on_gp19.83190NoNoNoNo88
61G.H5.15 I2x50 amine_on_gp98.00440NoNoNoNo78
62G.H5.15 G.H5.19 amine_on_gp97.58620NoNoNoNo74
63G.H5.19 I2x53 amine_on_gp97.29460NoNoYesYes48
645x58 6x37 amine_on_gp10.07490YesYesNoNo98
652x42 3x46 amine_on_gp49.07581.56799YesYesYesNo89
66b.l17x5 b.l19x1 amine_on_gp18.21690NoNoYesNo69
67b.l17x5 b.l19x2 amine_on_gp18.15090NoNoYesNo69
68b.b20x4 b.b20x6 amine_on_gp10.24440YesNoYesNo86
69b.b17x7 b.b20x6 amine_on_gp12.29890YesNoYesNo86
70b.l17x3 b.l19x2 amine_on_gp12.490YesNoYesNo99
71b.h2x1 b.h2x5 amine_on_gp10.40560YesNoNoNo55
72b.b21x5 b.h2x1 amine_on_gp11.92580YesNoYesNo45
73b.l2x3 b.l2x5 amine_on_gp12.6930NoNoNoNo85
74b.b3x1 b.l2x3 amine_on_gp12.56890NoNoNoNo58
75b.b3x1 b.b6x5 amine_on_gp12.44490NoNoYesNo56
76b.b21x5 b.b21x7 amine_on_gp15.68350YesNoYesNo45
77b.b21x7 b.b23x2 amine_on_gp10.19620YesNoNoNo56
78b.b21x7 b.b24x6 amine_on_gp32.43230YesNoYesNo58
79b.b23x6 b.b24x6 amine_on_gp33.23860YesNoYesNo78
80b.l21x7 b.l23x1 amine_on_gp41.15970NoNoYesNo56
81b.b23x6 b.l23x2 amine_on_gp38.27740YesNoYesNo78
823x43 6x44 amine_on_gp26.80741.88788YesNoYesYes89
833x43 7x53 amine_on_gp41.48280YesNoYesYes89
843x46 7x53 amine_on_gp42.60990YesNoYesYes99
855x54 6x44 amine_on_gp26.87480NoNoYesYes99
862x46 2x50 amine_on_gp13.96230YesNoYesYes99
87E1x51 E1x52 amine_on_gp11.22920NoNoNoNo57
88E1x50 E1x52 amine_on_gp12.87055.564YesYesNoNo97
89G.H2.07 b.l9x6 amine_on_gp19.57060YesNoYesNo98
90G.H3.17 b.l27x1 amine_on_gp12.31540YesNoYesNo49
91b.l21x7 b.l23x2 amine_on_gp40.31570NoNoYesNo58
92b.l23x1 b.l25x6 amine_on_gp12.07370YesNoYesNo68
933x47 5x57 Shared32.809827.4529NoNoNoNo97
943x48 5x57 Shared35.402258.3827NoNoNoNo67
953x48 3x52 Shared35.548159.5574NoNoNoNo65
963x52 I2x53 Shared35.694960.7006NoNoYesYes58
972x42 3x49 Shared60.182781.0058YesYesYesYes89
983x49 I2x53 Shared60.451360.3125YesYesYesYes98
996x48 Lig Shared44.771152.2681YesYesYesYes80
1006x44 6x48 Shared46.509811.2591YesYesYesYes98
1013x47 5x54 Shared26.933326.0056NoNoNoNo99
1022x45 4x46 Shared10.382794.4203NoNoNoNo98
1032x42 4x46 Shared10.530693.6756YesYesNoNo88
1047x42 Lig Shared18.254937.8677YesYesYesYes80
1052x50 7x46 Shared10.202534.3699YesYesNoNo99
1062x56 3x28 Shared18.619316.1676YesYesYesYes86
1072x60 3x28 Shared10.66712.6173YesYesYesYes76
1083x28 E1x50 Shared22.719816.6291YesYesYesYes69
1091x39 7x39 amine_off4.0214130.2323NoNoYesYes78
1107x39 7x42 amine_off5.2098232.503YesYesYesYes88
1112x56 7x42 amine_off5.6348128.8269YesYesYesYes88
1122x53 2x56 amine_off8.4181836.263NoNoYesYes88
1132x53 7x46 amine_off9.7546834.6111NoNoNoNo89
1141x50 2x50 amine_off9.867722.0934YesNoYesYes99
1156x48 7x45 amine_off0.0097045274.6762YesYesNoYes89
1167x45 7x49 amine_off0.30347785.1696NoYesYesYes99
1177x49 7x53 amine_off056.6626YesYesYesYes99
1187x53 8x50 amine_off046.2636YesYesYesYes98
1198x50 8x54 amine_off0.85717411.9251YesYesYesYes88
1201x53 7x53 amine_off010.8081NoNoYesYes99
1218x50 I1x50 amine_off2.1212419.0152YesYesYesYes88
1228x49 I1x50 amine_off0.25308112.2083NoNoYesYes78
1238x47 8x50 amine_off0.12673813.383NoNoYesYes98
1248x47 8x49 amine_off0.12660111.9041NoNoNoNo97
1252x50 3x39 amine_off0.450139100YesYesNoNo99
1262x46 3x39 amine_off099.3392YesNoNoNo99
1272x46 3x42 amine_off7.1231998.668YesNoYesNo98
1282x45 3x42 amine_off9.7881997.294NoNoYesNo98
1293x49 3x50 amine_off012.7222YesYesYesYes99
1303x49 I2x57 amine_off0.02220712.1821YesYesNoYes98
1312x38 I2x57 amine_off0.88738112.2555NoNoNoYes78
1322x38 4x39 amine_off0.5955710.8186NoNoNoNo75
1332x42 3x45 amine_off0.15215318.3387YesYesNoNo88
1341x50 2x51 amine_off3.1532714.437YesNoNoNo98
1351x47 2x51 amine_off2.2524111.3011NoNoNoNo78
136E2x52 Lig amine_off8.8397830.6309NoNoYesYes60
137E2 E2x52 amine_off8.2413429.4929YesYesNoNo46
1385x43 Lig amine_off1.7967513.9389NoNoYesYes80
1395x39 5x43 amine_off1.4975312.7956YesYesNoNo88
1403x40 6x44 amine_off1.4837418.454NoNoYesYes89
1413x40 5x50 amine_off1.2051316.6553NoNoYesNo89
1423x41 5x50 amine_off0.60687413.0264YesNoYesNo79
1433x51 5x57 amine_off2.5359834.3542NoYesNoNo97
1445x47 6x52 amine_off0.9147917.9401YesNoYesYes87
1455x47 5x48 amine_off1.1999810.6823YesNoNoNo87
1465x54 6x41 amine_off021.6005NoNoNoNo98
1475x58 6x41 amine_off1.2031917.0539YesYesNoNo98
1486x40 7x49 amine_off012.8743NoNoYesYes89
1496x51 7x38 amine_off0.0045748810.5302YesYesYesYes87
1506x51 7x34 amine_off032.8491YesYesNoYes84
1516x54 7x34 amine_off028.9423NoNoNoYes64
1526x54 7x37 amine_off0.30161226.5929NoNoNoNo66
1536x50 7x37 amine_off0.60321612.266NoNoNoNo96
1546x55 Lig amine_off1.4984810.2627NoYesYesYes80
1556x58 7x34 amine_off010.8343NoNoNoYes44
1563x41 4x52 amine_off0.75733911.1962YesNoNoNo75
1571x35 1x39 amine_off025.4916NoYesNoNo57
1581x35 2x65 amine_off0.29930516.0627NoYesNoNo56
1591x32 2x65 amine_off2.2265512.7851NoNoNoNo46
1601x32 NT amine_off1.927311.4217NoNoNoYes40
1613x45 4x45 amine_off016.8913NoNoNoNo86
1623x51 5x61 amine_off018.3177NoYesNoNo99
1637x33 7x37 amine_off012.2817NoNoNoNo66
1646x40 7x52 amine_off011.3011NoNoNoNo88
1654x41 4x45 amine_off015.36NoNoNoNo76
1668x48 8x49 amine_off021.0341NoNoNoNo67
1678x48 8x51 amine_off0.30081614.9405NoNoNoNo69
1683x54 5x61 amine_off0.30081616.7917NoNoNoNo99
1693x54 5x64 amine_off0.30081615.2341NoNoNoNo96
1705x64 5x68 amine_off011.0231NoNoNoNo67
1718x51 8x55 amine_off011.8779NoNoNoNo96
1722x57 7x42 amine_off0.91887519.7913YesYesYesYes88
1732x50 7x49 amine_off7.0007583.502YesYesYesYes99
1746x44 7x45 amine_off010.7557YesYesNoYes99
1756x48 6x51 amine_off021.569YesYesYesYes88
1766x48 6x52 amine_off0.8944411.2748YesYesYesYes87

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Midway



Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Node1Node2OwnerNet1LinkStrengthNet2LinkStrengthComm1Comm2Node1ShellNode2Shell
2x563x32Shared8.130117.975941121
2x567x42Shared4.931373.887031121
2x577x39Shared4.418593.227951122
2x577x42Shared6.098016.465971121
2x607x39Shared4.750983.197141122
2x607x42Shared4.319034.858441121
3x327x42Shared8.10119.005391111
3x32LigShared13.626212.39111110
3x334x57Shared7.049917.032420012
3x33LigShared11.531911.16210010
3x366x48Shared4.947594.53651111
3x36LigShared8.026367.81781110
3x374x53Shared5.199124.567070112
3x374x57amine_off4.1283900112
3x375x461Shared5.971565.414460111
3x406x44Shared6.202773.591170122
E2E2Shared42.005548.42321122
5x39E2Shared6.24316.395111122
E2x52LigShared3.938743.538911110
5x406x55Shared5.063113.523730021
5x43LigShared3.971043.816390010
5x461LigShared4.106863.435820110
5x476x52Shared26.354618.61090121
6x446x48Shared10.20714.975291121
6x447x45amine_off6.9923601122
6x486x51amine_off5.0917901111
6x486x52Shared3.573095.047861111
6x487x41Shared11.77878.003321112
6x487x45Shared3.752299.745381112
6x48LigShared10.32873.937691110
6x516x52Shared5.586315.348181111
6x516x55Shared6.662966.072621111
6x517x34amine_off5.1564101112
6x517x38Shared6.272345.626841111
6x51LigShared12.220712.50751110
6x52LigShared11.53625.568491110
6x557x34amine_off4.0762901112
6x55LigShared4.461753.596441110
7x387x42Shared5.39126.787351111
7x38LigShared9.117178.087081110
7x397x42Shared7.259767.716621121
7x42LigShared4.813985.780021110
E2E2x52Shared8.374535.767791121
5x395x43Shared4.184215.672461121
2x607x38Shared4.179073.550671121
5x446x52Shared2.87123.613350021
3x37Ligamine_on_gp02.860320110
3x29E2x52amine_on_gp03.317220021
3x373x41amine_on_gp02.86390112
3x406x48amine_on_gp08.039670121
5x476x44amine_on_gp04.848970122
5x476x48amine_on_gp03.746140121
3x374x56amine_on_gp02.400460112

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
Id Description
amine_on_gp 5ht_on_gp
adrenergic_on_gp
dopamine_on_gp
histamine_on_gp
muscarinic_on_gp
trace-amine_on_gp
amine_off 5ht_off
adrenergic_off
dopamine_off
histamine_off
muscarinic_off
Network Difference
Value amine_on_gp amine_off
Imin 2.77146 3.51218
Number of Linked Nodes 977 298
Number of Specific Nodes 683 (69.91%) 4  (1.34%)
Number of Shared Nodes 294 (30.09%) 294  (98.66%)
Number of Links 1168 323
Number of Specific Links 955 (81.76%) 110  (34.06%)
Number of Shared Links 213 (18.24%) 213  (65.94%)
Number of Hubs 180 37
Number of Specific Hubs 152 (84.44%) 9  (24.32%)
Number of Shared Hubs 28 (15.56%) 28  (75.68%)
Average % Shared Neighbours (Jaccard) 16.21
Average % Shared Neighbours (Otsuka) 18.62
Average % Shared Neighbours (Overlap Coefficient) 21.23
Average % Shared Cliques (k3-6) 52.93
Graphlets Similarity 0.629515
Paths Difference
Value amine_on_gp amine_off
Number Of Nodes in MetaPath 106 82
Specific Nodes in MetaPath 82 (77.36%) 58  (70.73%)
Shared Nodes in MetaPath 294 (30.09%) 294  (30.09%)
Number Of Links MetaPath 108 84
Specific Links in MetaPath 92 (85.19%) 68  (80.95%)
Shared Links in MetaPath 213 (18.24%) 213  (18.24%)
Number of Shortest Paths 13717549 49697
Length Of Smallest Path 3 3
Average Path Length 52.9654 13.6424
Length of Longest Path 79 33
Minimum Path Strength 0.195727 0.456802
Average Path Strength 4.67621 4.9939
Maximum Path Strength 21.2858 18.9454
Minimum Path Correlation 0.700619 0.700929
Average Path Correlation 0.994965 0.900574
Maximum Path Correlation 1 0.988817
Minimum % Of Corr. Nodes 1.35135 3.33333
Average % Of Corr. Nodes 21.772 41.0779
Maximum % Of Corr. Nodes 100 100
Minimum Path Hubs % 0 0
Average Path Hubs % 57.2752 43.7246
Maximum Path Hubs % 100 100

Details about the values in these tables can be found in the corresponding documentation page .

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download amine_off_on_gp.zip<



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