Orange: nodes, hubs and links specific of arrestin1 network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of arrestin2 network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.


Index Hub Owner arrestin1 Avg Int. Strength arrestin2 Avg Int. Strength arrestin1 Num Of Links arrestin2 Num Of Links ConSurf
11x30 arrestin17.742.37412
21x38 arrestin19.041.18833424
3I1x50 arrestin16.00753.43556438
42x45 arrestin16.5025.83539
52x57 arrestin15.031677.40167627
63x33 arrestin14.94255.27444435
73x38 arrestin15.128333.43833627
83x42 arrestin14.24.96111437
93x44 arrestin15.33252.9417
103x46 arrestin16.856.25333529
113x50 arrestin17.1656.40333439
12I2x50 arrestin14.99754.17333427
13I2x56 arrestin16.282.28333416
144x49 arrestin13.56754.39416
15E2x52 arrestin13.70256.285424
165x461 arrestin18.906674.48626
175x50 arrestin17.23253.48438
185x55 arrestin14.61.53667424
196x40 arrestin111.33252.035428
206x58 arrestin14.8058.04425
217x31 arrestin14.9857.93111434
227x37 arrestin15.32752.86444437
237x48 arrestin15.29752.24425
24N.s1s2.05 arrestin15.35256.97333435
25N.S2.05 arrestin13.173.69333418
26N.S3.02 arrestin15.839.34537
27N.S4.01 arrestin15.87757.64667427
28N.s4s5.05 arrestin13.9954.66667424
29N.S5.05 arrestin14.757.11333526
30N.s5s6.08 arrestin18.121.77667437
31N.S6.03 arrestin17.763.80667529
32N.S6.06 arrestin18.864.265424
33N.S6.07 arrestin18.0554.26667414
34N.S6.09 arrestin17.45610.7233514
35N.S7.01 arrestin15.61253.67667418
36N.s7s8.05 arrestin16.8453.87333425
37N.S9.08 arrestin15.887.16778438
38N.S10.02 arrestin13.90254.89444437
39C.s11s12.06 arrestin14.62255.075427
40C.s12s13.02 arrestin17.47756.45222438
41C.s12s13.03 arrestin17.09255.305427
42C.s13s14.03 arrestin16.92754.06556437
43C.S14.01 arrestin18.628.46333428
44C.S14.02 arrestin14.013.23434
45C.S14.03 arrestin14.9853.305427
46C.S14.08 arrestin13.03254.40333435
47C.S15.08 arrestin13.923.03167427
48C.S15.13 arrestin19.111.3133416
49C.s15s16.02 arrestin15.6146.29167528
50C.s16s17.05 arrestin13.3553.42414
51C.S17.09 arrestin14.38755.69167425
52C.s17s18.04 arrestin14.075.11167428
53C.s17s18.31 arrestin14.815.65667415
54C.S18.01 arrestin15.4254.64111438
55C.S19.10 arrestin17.35753.60889434
56NT Shared43.39236.9821350
571x39 Shared5.2063.39417547
581x50 Shared6.54253.98449
592x42 Shared6.2154.63667447
60E1x50 Shared6.3126.12952578
613x37 Shared8.5744.3625546
623x41 Shared8.366674.8425646
63E2 Shared16.019412.416531180
645x39 Shared9.225.28933456
655x58 Shared4.346675.53067659
66E3 Shared7.786678.12542680
677x42 Shared5.34.485447
687x53 Shared12.485.86083449
698x49 Shared6.6854.7275447
708x50 Shared5.925.36524678
71CT Shared13.071724.197812120
72N.s1s2.03 Shared4.76256.6375448
73N.S2.04 Shared9.0110.5667448
74N.s2s3.03 Shared7.337.58667449
75N.S5.02 Shared4.874.03417447
76N.S5.03 Shared8.8628.526554
77N.S5.10 Shared4.963333.66417649
78N.S5.12 Shared4.4928.48583549
79N.s5s6.05 Shared5.762.304458
80N.S6.01 Shared3.572.958459
81N.S7.04 Shared6.246.2125449
82N.S7.06 Shared4.7425.12533557
83N.s8s9.01 Shared5.83254.02333448
84N.s8s9.06 Shared8.48754.4925448
85N.S9.05 Shared7.05255.728457
86N.S10.07 Shared8.68755.0425449
87N.S10.08 Shared8.81756.3225449
88C.s10s11.09 Shared5.2855.08167449
89C.S13.02 Shared7.818338.35333656
90C.S15.09 Shared8.6366.44389565
91C.s15s16.03 Shared4.38758.16333457
92C.s16s17.04 Shared3.464.74446
93C.S18.05 Shared7.349.58083549
94C.S19.09 Shared5.09255.50667445
951x57 arrestin25.93.895247
961x60 arrestin22.823.50133355
972x39 arrestin26.216674.50083348
982x40 arrestin26.986674.92467358
992x46 arrestin23.744.97333349
1002x50 arrestin28.166674.83933359
1013x26 arrestin22.645.83917247
1023x29 arrestin24.357.30667145
1033x30 arrestin24.7253.83533256
1043x32 arrestin203.772056
1053x49 arrestin26.896674.00417348
1063x51 arrestin23.296676.73917348
1074x39 arrestin24.026.515241
1084x50 arrestin28.633.81259
1094x61 arrestin24.125.7525145
1105x47 arrestin26.02510.43248
1115x64 arrestin24.413.91667245
1126x32 arrestin22.333.8375147
1136x41 arrestin24.7653.51583248
1146x44 arrestin24.403338.24349
1156x47 arrestin26.463332.80917349
1166x48 arrestin29.383336.93619378
1176x51 arrestin26.475.94667346
1186x52 arrestin28.326.61333178
1197x38 arrestin23.216.40133155
1207x49 arrestin25.8355.42167249
1218x54 arrestin23.013.65067156
1228x57 arrestin27.933.20833165
123N.s3s4.01 arrestin25.544.2575146
124N.S5.04 arrestin25.996674.81167347
125N.S5.11 arrestin210.656.046258
126N.s5s6.02 arrestin22.194.78905278
127N.H1.03 arrestin27.603337.47933359
128N.H1.05 arrestin209.27047
129N.H1.06 arrestin27.1854.755249
130N.H1.10 arrestin28.206675.50667347
131N.s7s8.03 arrestin212.30674.43833346
132N.s7s8.07 arrestin23.7953.99417249
133N.S9.11 arrestin23.4054.81917246
134N.s9s10.08 arrestin26.344.28267356
135N.s9s10.11 arrestin25.263.69667255
136C.s11s12.01 arrestin23.963.614159
137C.S12.07 arrestin27.985.29417247
138C.s13s14.01 arrestin212.169.43249
139C.S14.06 arrestin23.673334.13333344
140C.s14s15.04 arrestin22.0054.23467258
141C.S15.06 arrestin25.084.26344
142C.S15.10 arrestin28.217.6825348
143C.S15.11 arrestin24.098.45444264
144C.S16.03 arrestin211.09673.86778367
145C.S17.07 arrestin23.856677.32619374
146C.s17s18.18 arrestin25.976675.805345
147C.s17s18.19 arrestin28.086675.18347
148C.s17s18.28 arrestin28.834.58583149
149C.s17s18.33 arrestin26.333.81417245
150C.S18.06 arrestin212.87676.262355
151C.S18.08 arrestin27.373.97667347
152C.S18.11 arrestin24.935.24333246
153C.S19.06 arrestin211.875.0575247
154C.S19.07 arrestin22.896674.06346
155C.S19.12 arrestin24.043.86083348
156Lig arrestin209.555780150
   
Orange: nodes, hubs and links specific of arrestin1 network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of arrestin2 network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Owner arrestin1 Recurrence arrestin2 Recurrence arrestin1 Hub1? arrestin2 Hub1? arrestin1 Hub2? arrestin2 Hub2? ConSurf1 ConSurf2
17x42 E2 arrestin111.06230YesYesYesYes70
23x42 4x49 arrestin173.72860YesNoYesNo76
33x41 4x49 arrestin170.24160.515185YesYesYesNo66
43x41 5x461 arrestin151.71940YesYesYesNo66
55x42 5x461 arrestin149.51110NoNoYesNo36
65x42 E2 arrestin149.220NoNoYesYes30
72x42 3x42 arrestin180.40640YesYesYesNo77
82x39 N.s5s6.05 arrestin112.89560NoYesYesYes88
92x39 I2x56 arrestin181.25370NoYesYesNo86
103x49 I2x56 arrestin179.18770NoYesYesNo86
112x42 3x49 arrestin178.2643.15236YesYesNoYes78
122x39 3x53 arrestin193.37490NoYesNoNo88
133x40 6x48 arrestin113.86890NoNoNoYes78
14I2x53 N.S5.12 arrestin193.98450NoNoYesYes59
153x53 I2x53 arrestin193.60890.650887NoNoNoNo85
16I2x50 N.S5.10 arrestin148.13710YesNoYesYes79
17C.s15s16.02 N.S5.12 arrestin147.05870YesNoYesYes89
18C.s17s18.38 I3 arrestin110.67170NoNoNoNo50
19C.s17s18.38 N.s7s8.05 arrestin112.18610NoNoYesNo55
20N.S10.08 N.s7s8.06 arrestin116.69270YesYesNoNo97
21N.S10.08 N.S9.05 arrestin175.03651.96467YesYesYesYes97
22N.S5.08 N.S9.05 arrestin199.89320.49477NoNoYesYes97
23N.S5.08 N.S6.05 arrestin199.94690NoNoNoNo98
24N.S5.10 N.S6.05 arrestin11003.43337YesYesNoNo98
25C.s17s18.19 N.s2s3.03 arrestin110.66312.56512NoYesYesYes79
26C.s17s18.19 N.S10.07 arrestin111.28065.28515NoYesYesYes79
27N.S10.07 N.s7s8.09 arrestin112.21651.15586YesYesNoNo99
28N.S9.05 N.s7s8.09 arrestin112.53640YesYesNoNo79
29N.S5.06 N.S7.06 arrestin133.21950.945107NoNoYesYes67
30N.S5.06 N.s7s8.02 arrestin133.51230NoNoNoNo65
31N.S9.05 N.s7s8.02 arrestin122.80831.35822YesYesNoNo75
32N.H1.02 N.H1.06 arrestin110.09450.076257NoNoNoYes59
33N.S10.08 N.S3.04 arrestin167.57020.489366YesYesNoNo99
34N.s3s4.05 N.s7s8.02 arrestin111.43590.889265NoNoNoNo75
35N.S10.10 N.S3.04 arrestin177.22080.00480359NoNoNoNo99
36C.S15.08 C.S16.07 arrestin120.41530YesNoNoNo78
37C.S15.08 C.S18.07 arrestin121.12490.986538YesNoNoNo77
38C.S18.07 C.S19.09 arrestin122.01241.47831NoNoYesYes75
39C.S18.05 C.s17s18.29 arrestin164.90750YesYesNoNo98
40C.S19.10 C.s17s18.29 arrestin132.78610.482761YesNoNoNo48
41C.S19.10 C.s17s18.31 arrestin143.28470YesNoYesNo45
42C.s17s18.31 N.S10.10 arrestin176.69340YesNoNoNo59
43C.S19.12 C.s17s18.29 arrestin132.63110NoYesNoNo88
44C.S19.12 C.s17s18.31 arrestin133.07030.482761NoYesYesNo85
45C.s17s18.10 C.s17s18.13 arrestin111.6910NoNoNoNo77
46C.s17s18.07 C.s17s18.10 arrestin112.26546.32994NoNoNoNo97
47C.S16.07 C.s17s18.07 arrestin112.84298.23696NoNoNoNo89
48C.S14.06 C.S17.04 arrestin124.8425.85018NoYesNoNo45
49C.S14.04 C.S17.04 arrestin125.96076.32994NoNoNoNo55
50C.S14.04 C.S17.06 arrestin128.1987.76201NoNoNoNo55
51C.S14.02 C.S17.06 arrestin129.32188.23696YesNoNoNo45
52C.S13.02 C.S14.02 arrestin115.24320YesYesYesNo64
53C.S14.01 C.S14.02 arrestin115.17480YesNoYesNo84
54C.S14.01 C.S19.09 arrestin117.95710YesNoYesYes85
55C.S14.06 C.S14.08 arrestin121.48512.9428NoYesYesNo45
56C.s11s12.06 C.s14s15.03 arrestin110.25460YesNoNoNo75
57C.s11s12.06 C.s11s12.07 arrestin113.64770.986538YesNoNoNo76
58C.s11s12.07 C.s14s15.01 arrestin115.88570NoNoNoNo65
59C.S14.08 C.s14s15.01 arrestin117.00532.45824YesNoNoNo55
60C.S15.09 C.S16.06 arrestin110.01360YesYesNoNo53
61C.S16.05 C.S16.06 arrestin110.5974.88706NoNoNoNo53
62C.S16.05 C.s17s18.13 arrestin111.17960NoNoNoNo57
632x40 N.s5s6.05 arrestin110.61740NoYesYesYes88
64I2x50 N.S5.12 Shared47.507578.4337YesNoYesYes79
65C.s15s16.02 N.S5.10 Shared53.017771.095YesNoYesYes89
66N.S5.02 N.S6.12 Shared10.582222.3974YesYesNoNo75
67N.S5.04 N.S6.12 Shared11.250922.8297NoYesNoNo75
68N.S5.04 N.S7.06 Shared11.543323.4463NoYesYesYes77
69N.S3.02 N.S4.01 Shared11.786648.3404YesNoYesNo77
70N.S4.01 N.S7.06 Shared18.903847.9921YesNoYesYes77
71C.S18.05 C.S19.09 Shared58.327852.7158YesYesYesYes95
72C.S13.02 C.S19.09 Shared20.237655.7229YesYesYesYes65
73E2 Lig arrestin2017.1458YesYesNoYes00
746x52 Lig arrestin2035.7952NoYesNoYes80
756x48 6x52 arrestin2048.7613NoYesNoYes88
766x48 7x45 arrestin2069.027NoYesNoNo89
777x45 7x49 arrestin20.75206270.3324NoNoNoYes99
782x46 7x49 arrestin2068.9292NoYesNoYes99
792x46 3x43 arrestin21.239883.221NoYesNoNo99
803x43 7x53 arrestin21.5223483.3934NoNoYesYes99
817x53 8x50 arrestin2012.6839YesYesYesYes98
823x46 7x53 arrestin23.3630383.1436YesNoYesYes99
833x46 3x50 arrestin20.88758183.2691YesNoYesNo99
842x39 3x50 arrestin2019.8665NoYesYesNo89
852x39 2x40 arrestin2017.2059NoYesNoYes88
863x50 N.s5s6.06 arrestin20100YesNoNoNo99
87N.S6.01 N.s5s6.06 arrestin2097.6462YesYesNoNo99
88N.S5.12 N.S6.01 arrestin2099.5539YesYesYesYes99
89C.s15s16.03 N.S5.12 arrestin20.39217274.9625YesYesYesYes79
906x44 6x48 arrestin26.2367211.2182NoYesNoYes98
91C.S16.03 I2x50 arrestin2078.2025NoYesYesNo77
92C.S15.14 C.S16.03 arrestin22.178275.967NoNoNoYes87
937x34 7x38 arrestin2017.2737NoNoNoYes45
946x54 7x34 arrestin2022.1061NoNoNoNo54
956x54 7x30 arrestin2016.7802NoNoNoNo53
967x30 7x33 arrestin2015.3643NoNoNoNo35
977x32 7x33 arrestin2010.5337NoNoNoNo15
98C.s15s16.02 C.s15s16.03 arrestin25.6697171.3634YesNoYesYes87
99N.S5.10 N.S9.03 arrestin20.35605568.6253YesYesNoNo99
100N.S9.03 N.s7s8.07 arrestin2068.3449NoNoNoYes99
101N.s7s8.06 N.s7s8.07 arrestin2066.0584NoNoNoYes79
102N.S9.05 N.s7s8.06 arrestin2063.7857YesYesNoNo77
103N.S10.06 N.S9.05 arrestin2061.7448NoNoYesYes87
104N.S10.06 N.S3.02 arrestin20.37299561.4296NoNoYesNo87
105N.S7.04 N.S7.06 arrestin24.6939223.2506YesYesYesYes97
106N.S4.05 N.S7.04 arrestin2022.6591NoNoYesYes49
107N.S2.03 N.S4.05 arrestin2022.3031NoNoNoNo54
108N.S10.02 N.S2.03 arrestin23.7433721.971YesNoNoNo75
109N.S1.04 N.S10.02 arrestin20.88438419.7416NoNoYesNo97
110CT N.S1.04 arrestin21.085117.3344YesYesNoNo09
111N.S3.02 N.s2s3.02 arrestin23.6593114.1754YesNoNoNo78
112N.s2s3.02 N.s3s4.06 arrestin23.2962313.7623NoNoNoNo86
113N.S3.03 N.s3s4.06 arrestin21.8374912.9781NoNoNoNo86
114N.S3.03 N.s3s4.01 arrestin20.3685210.473NoNoNoYes86
115N.S5.02 N.S9.11 arrestin2020.1529YesYesNoYes76
116N.S9.11 N.s9s10.14 arrestin20.049860515.8585NoYesNoNo68
117N.s9s10.11 N.s9s10.14 arrestin21.1982512.8364NoYesNoNo58
118N.s9s10.08 N.s9s10.11 arrestin2010.3896NoYesNoYes65
119C.S15.14 C.S18.01 arrestin2075.9616NoNoYesNo88
120C.S18.01 N.S8.01 arrestin20.36084973.7189YesNoNoNo89
121C.s17s18.27 N.S8.01 arrestin2073.4638NoNoNoNo99
122C.S18.03 C.s17s18.27 arrestin20.59097573.2074NoNoNoNo99
123C.S18.03 C.S18.05 arrestin21.1797171.8203NoNoYesYes99
124C.S18.05 C.S19.11 arrestin24.007719.191YesYesNoNo99
125C.S19.11 C.s13s14.01 arrestin23.4208823.0765NoNoNoYes99
126C.s17s18.16 C.s17s18.18 arrestin2017.2023NoNoNoYes95
127C.s17s18.18 C.s17s18.24 arrestin22.3738110.3559NoYesNoNo58
128C.s13s14.01 C.s17s18.28 arrestin2012.7199NoYesNoYes99
129C.S12.07 C.S13.02 arrestin2038.4876NoYesYesYes76
130C.S12.07 C.S14.03 arrestin27.8146729.6634NoYesYesNo77
131C.S14.03 C.S14.05 arrestin2029.2485YesNoNoNo76
132C.S14.05 C.S17.07 arrestin2027.0779NoNoNoYes64
133C.S15.04 C.S17.07 arrestin2019.995NoNoNoYes64
134C.S15.04 C.S18.11 arrestin25.4485419.5608NoNoNoYes66
135C.S15.01 C.S18.11 arrestin2017.3692NoNoNoYes76
136C.S15.01 C.S18.13 arrestin20.31674217.0978NoNoNoNo75
137C.S18.13 C.s11s12.01 arrestin2016.6493NoNoNoYes59
138C.s11s12.01 C.s11s12.04 arrestin2013.2195NoYesNoNo99
139C.S13.02 C.S14.01 arrestin20.018857510.5937YesYesYesNo68
140C.S14.01 C.s17s18.02 arrestin22.3290610.1248YesNoNoNo89
1416x51 7x38 arrestin2011.4974NoYesNoYes65

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Midway



Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


Difference Members
Id Description
arrestin1 5W0P-Rhodopsin-Arrestin1
arrestin2 6TKO-β1-Arformoterol-Arrestin2
6PWC-NTS1-Neurotensin-Arrestin2
7R0C-V2-Acyclovir triphosphate-Arrestin2
Network Difference
Value arrestin1 arrestin2
Imin 2.98 2.99667
Number of Linked Nodes 579 644
Number of Specific Nodes 6 (1.04%) 71  (11.02%)
Number of Shared Nodes 573 (98.96%) 573  (88.98%)
Number of Links 686 745
Number of Specific Links 369 (53.79%) 428  (57.45%)
Number of Shared Links 317 (46.21%) 317  (42.55%)
Number of Hubs 94 101
Number of Specific Hubs 55 (58.51%) 62  (61.39%)
Number of Shared Hubs 39 (41.49%) 39  (38.61%)
Average % Shared Neighbours (Jaccard) 29.81
Average % Shared Neighbours (Otsuka) 39.00
Average % Shared Neighbours (Overlap Coefficient) 48.24
Average % Shared Cliques (k3-6) 51.40
Graphlets Similarity 0.740184
Paths Difference
Value arrestin1 arrestin2
Number Of Nodes in MetaPath 73 81
Specific Nodes in MetaPath 53 (72.60%) 61  (75.31%)
Shared Nodes in MetaPath 573 (98.96%) 573  (98.96%)
Number Of Links MetaPath 72 78
Specific Links in MetaPath 63 (87.50%) 69  (88.46%)
Shared Links in MetaPath 317 (46.21%) 317  (46.21%)
Number of Shortest Paths 470510 325251
Length Of Smallest Path 3 3
Average Path Length 25.3875 23.5801
Length of Longest Path 53 52
Minimum Path Strength 1.135 0.718333
Average Path Strength 6.32645 5.38059
Maximum Path Strength 38.255 28.74
Minimum Path Correlation 0.7 0.7
Average Path Correlation 0.963099 0.959071
Maximum Path Correlation 1 1
Minimum % Of Corr. Nodes 3.44828 2.08333
Average % Of Corr. Nodes 43.9003 43.5715
Maximum % Of Corr. Nodes 100 100
Minimum Path Hubs % 0 0
Average Path Hubs % 46.5439 42.7978
Maximum Path Hubs % 100 100

Details about the values in these tables can be found in the corresponding documentation page .

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download arrestin1_arrestin2.zip<



You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.



You can also  read or  download a guide explaining the meaning of all files and numerical data.