psnGPCR

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Orange: nodes, hubs and links specific of at1_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of at1_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	at1_off Int. Strength	at1_on Int. Strength	at1_off Hub1?	at1_on Hub1?	at1_off Hub2?	at1_on Hub2?	ConSurf1	ConSurf2
1	1x39	Lig	at1_off	9.995	0	Yes	Yes	Yes	Yes	7	0
2	3x29	Lig	at1_off	3.345	0	No	No	Yes	Yes	5	0
3	4x65	Lig	at1_off	24.47	0	No	No	Yes	Yes	5	0
4	7x42	Lig	at1_off	3.76	0	Yes	No	Yes	Yes	7	0
5	NT.N14	NT.S16	at1_off	4.47	0	No	No	No	No	3	4
6	7x27	NT.C18	at1_off	3.61	0	No	No	No	No	3	8
7	NT.K20	NT.R23	at1_off	6.19	0	No	No	No	No	6	4
8	1x32	NT.R23	at1_off	5.34	0	No	No	No	No	4	4
9	1x30	7x32	at1_off	4.37	0	No	No	Yes	No	6	1
10	1x31	7x32	at1_off	3.8	0	Yes	No	Yes	No	3	1
11	1x34	7x36	at1_off	5.83	0	No	No	Yes	No	4	6
12	1x35	2x64	at1_off	8.36	0	Yes	Yes	No	No	6	5
13	1x42	7x43	at1_off	8.165	0	No	No	No	No	7	5
14	1x42	7x47	at1_off	5.725	0	No	No	No	No	7	8
15	1x47	2x54	at1_off	4.28	0	Yes	No	No	No	6	6
16	1x50	2x51	at1_off	3.43	0	No	No	No	No	9	7
17	1x53	7x53	at1_off	11.985	0	No	Yes	No	Yes	9	9
18	1x54	2x44	at1_off	3.725	0	No	No	Yes	No	7	5
19	1x57	I1x50	at1_off	4.28	0	No	No	Yes	No	7	7
20	1x57	2x40	at1_off	3.87	0	No	No	Yes	No	7	8
21	1x58	I1x50	at1_off	4.1	0	No	No	Yes	No	4	7
22	1x58	2x44	at1_off	6.45	0	No	No	Yes	No	4	5
23	2x38	3x49	at1_off	8.03	0	No	No	No	No	7	8
24	2x42	4x46	at1_off	4.89	0	Yes	Yes	No	No	7	7
25	2x43	7x53	at1_off	7.62	0	No	No	No	Yes	8	9
26	2x52	4x50	at1_off	3.265	0	No	No	Yes	Yes	7	9
27	2x53	2x57	at1_off	6.7	0	Yes	No	Yes	Yes	6	8
28	2x53	3x32	at1_off	6.55	0	Yes	No	No	No	6	6
29	2x53	7x42	at1_off	14.44	0	Yes	No	Yes	No	6	7
30	2x53	7x46	at1_off	13.895	0	Yes	No	Yes	No	6	9
31	2x59	E1x50	at1_off	3.42	0	No	No	Yes	Yes	6	9
32	2x60	E1x50	at1_off	10.31	0	Yes	Yes	Yes	Yes	7	9
33	2x60	3x29	at1_off	4.94	0	Yes	Yes	No	No	7	5
34	2x60	E2x50	at1_off	3.265	0	Yes	Yes	No	No	7	9
35	7x35	E1.Y92	at1_off	3.475	0	No	No	Yes	Yes	5	4
36	3x26	E2.N168	at1_off	6.295	0	No	No	No	No	6	3
37	3x34	4x57	at1_off	3.3	0	Yes	Yes	No	No	5	7
38	3x35	7x42	at1_off	6.975	0	No	No	Yes	No	8	7
39	3x35	7x46	at1_off	12.26	0	No	No	Yes	No	8	9
40	3x39	6x44	at1_off	5.285	0	No	No	Yes	No	9	9
41	3x41	4x49	at1_off	5.65	0	No	No	No	No	5	7
42	3x43	6x41	at1_off	5.215	0	No	No	No	No	8	8
43	3x43	6x44	at1_off	6.7	0	No	No	Yes	No	8	9
44	3x44	5x54	at1_off	7.6	0	No	No	Yes	No	7	8
45	3x46	6x37	at1_off	9.99	0	No	No	Yes	No	9	7
46	3x49	3x50	at1_off	6.55	0	No	No	Yes	No	8	9
47	3x50	3x53	at1_off	4.15	0	Yes	No	No	No	9	8
48	3x50	6x30	at1_off	4.22	0	Yes	No	Yes	No	9	6
49	3x50	6x37	at1_off	3.76	0	Yes	No	Yes	No	9	7
50	3x51	5x57	at1_off	4.455	0	Yes	Yes	No	No	8	7
51	3x54	6x30	at1_off	9.205	0	No	No	Yes	No	8	6
52	I2x54	I2x56	at1_off	5.33	0	No	No	No	No	4	4
53	I2x54	I2x57	at1_off	4.8	0	No	No	No	Yes	4	6
54	4x51	4x55	at1_off	4.15	0	No	No	No	No	4	4
55	4x63	4x64	at1_off	9.28	0	No	No	No	No	4	4
56	4x64	E2x52	at1_off	14.71	0	No	No	No	Yes	4	4
57	E2.F170	E2.N168	at1_off	7.855	0	No	No	No	No	3	3
58	E2.T178	E2.V169	at1_off	4.76	0	No	No	No	No	4	5
59	E2.I172	E2.I177	at1_off	5.89	0	No	No	No	No	5	1
60	5x44	5x47	at1_off	4.23	0	No	No	Yes	Yes	4	8
61	5x45	5x48	at1_off	3.57	0	No	No	No	No	5	4
62	5x45	5x49	at1_off	9.42	0	No	No	Yes	No	5	6
63	5x48	5x49	at1_off	6.7	0	No	No	Yes	No	4	6
64	5x54	5x58	at1_off	3.63	0	Yes	No	Yes	Yes	8	9
65	5x54	6x45	at1_off	4.395	0	Yes	No	Yes	Yes	8	5
66	5x61	6x34	at1_off	8.795	0	No	No	No	Yes	8	6
67	5x65	6x30	at1_off	6.865	0	No	No	Yes	No	8	6
68	6x30	6x31	at1_off	4.715	0	Yes	No	No	No	6	4
69	6x32	6x35	at1_off	3.455	0	No	No	No	No	7	5
70	6x35	7x55	at1_off	9.305	0	No	No	No	No	5	6
71	6x36	7x53	at1_off	4.23	0	No	No	No	Yes	8	9
72	6x36	7x55	at1_off	3.77	0	No	No	No	No	8	6
73	6x40	7x49	at1_off	8.5	0	No	No	No	No	8	9
74	6x40	7x52	at1_off	3.77	0	No	No	Yes	No	8	8
75	6x41	6x45	at1_off	3.275	0	No	No	Yes	Yes	8	5
76	6x44	6x45	at1_off	5.895	0	Yes	No	Yes	Yes	9	5
77	6x44	7x45	at1_off	7.855	0	Yes	No	No	No	9	9
78	6x48	7x41	at1_off	9.725	0	Yes	Yes	No	No	8	8
79	6x48	7x42	at1_off	7.235	0	Yes	Yes	Yes	No	8	7
80	6x58	6x62	at1_off	9.14	0	No	No	No	No	4	3
81	6x58	7x34	at1_off	5.545	0	No	No	No	No	4	4
82	6x63	E3.I270	at1_off	4.995	0	Yes	No	No	No	1	2
83	7x23	7x26	at1_off	11.895	0	No	No	No	No	4	1
84	7x25	7x29	at1_off	4.385	0	No	No	No	No	2	1
85	7x43	7x47	at1_off	3.49	0	No	No	No	No	5	8
86	7x45	7x46	at1_off	8.175	0	No	No	Yes	No	9	9
87	7x45	7x49	at1_off	11.58	0	No	No	No	No	9	9
88	7x48	7x52	at1_off	4.26	0	No	No	Yes	No	6	8
89	8x53	8x57	at1_off	4.69	0	No	Yes	No	No	5	4
90	5x47	5x51	at1_off	6.965	0	Yes	Yes	No	No	8	6
91	6x61	7x27	at1_off	3.25	0	No	No	No	No	2	3
92	2x63	E2.V179	at1_off	3.155	0	Yes	Yes	No	No	5	3
93	E3.R272	NT.D17	at1_off	2.98	0	No	No	No	No	1	6
94	6x33	6x37	at1_off	2.94	0	No	No	Yes	No	7	7
95	6x58	7x30	at1_off	2.92	0	No	No	Yes	No	4	4
96	7x30	7x31	at1_off	2.92	0	Yes	No	No	No	4	4
97	4x59	4x63	at1_off	2.855	0	No	No	No	No	4	4
98	5x37	6x63	at1_off	2.855	0	No	No	Yes	No	2	1
99	2x42	4x42	at1_off	2.77	0	Yes	Yes	No	No	7	7
100	2x46	3x42	at1_off	2.77	0	No	Yes	No	No	9	7
101	3x34	3x38	at1_off	2.77	0	Yes	Yes	No	No	5	7
102	6x54	7x30	at1_off	2.62	0	No	No	Yes	No	5	4
103	5x40	5x43	at1_off	2.615	0	No	No	No	Yes	5	5
104	E1x49	E2.T178	at1_off	2.585	0	No	No	No	No	5	4
105	1x31	7x35	at1_off	2.54	0	Yes	No	No	No	3	5
106	6x46	6x49	at1_off	2.51	0	No	No	No	Yes	6	5
107	E2.F170	NT.L13	at1_off	2.435	0	No	No	No	No	3	4
108	5x46	5x49	at1_off	2.435	0	No	No	Yes	No	4	6
109	1x60	8x49	at1_off	2.39	0	Yes	Yes	No	No	4	6
110	2x38	4x38	at1_off	2.38	0	No	No	No	No	7	7
111	7x25	7x28	at1_off	2.38	0	No	No	No	No	2	4
112	6x47	7x40	at1_off	2.325	0	No	No	No	No	8	8
113	2x39	3x49	at1_off	2.315	0	No	No	No	No	7	8
114	2x41	I1x50	at1_off	2.235	0	Yes	Yes	Yes	No	6	7
115	4x38	I2x55	at1_off	2.21	0	No	No	No	No	7	4
116	E2.E173	NT.S15	at1_off	2.155	0	No	No	No	No	0	4
117	4x48	4x52	at1_off	2.14	0	No	No	No	No	3	4
118	I1x51	I2x55	at1_off	2.115	0	No	No	No	No	7	4
119	1x60	8x50	at1_off	2.065	0	Yes	Yes	No	Yes	4	8
120	5x41	5x44	at1_off	2.06	0	No	No	No	No	4	4
121	4x61	Lig	at1_off	2.02	0	No	No	Yes	Yes	4	0
122	1x43	1x44	at1_off	1.965	0	Yes	No	No	No	6	5
123	E1x49	E2.N176	at1_off	1.81	0	No	No	No	No	5	0
124	2x49	3x38	at1_off	1.79	0	No	No	No	No	8	7
125	3x30	4x61	at1_off	1.79	0	No	No	No	No	5	4
126	5x37	5x38	at1_off	1.765	0	No	No	No	No	2	4
127	1x45	7x47	at1_off	1.71	0	No	No	No	No	5	8
128	2x48	4x50	at1_off	1.71	0	No	No	Yes	Yes	5	9
129	2x56	3x28	at1_off	1.68	0	No	No	No	No	7	6
130	5x35	5x36	at1_off	1.64	0	No	No	No	No	1	3
131	5x42	5x45	at1_off	1.52	0	No	No	No	No	3	5
132	NT.L13	NT.S15	at1_off	1.5	0	No	No	No	No	4	4
133	5x35	E2.S189	at1_off	1.5	0	No	No	No	No	1	0
134	5x39	5x42	at1_off	1.475	0	No	No	No	No	5	3
135	NT.D17	NT.S16	at1_off	1.47	0	No	No	No	No	6	4
136	1x37	1x38	at1_off	1.47	0	No	No	No	No	6	5
137	7x36	7x40	at1_off	1.47	0	Yes	No	No	No	6	8
138	1x31	7x36	at1_off	1.47	0	Yes	No	Yes	No	3	6
139	8x48	8x51	at1_off	1.435	0	No	No	No	No	5	8
140	3x24	3x27	at1_off	1.425	0	No	No	No	No	5	6
141	7x48	7x51	at1_off	1.385	0	No	No	No	No	6	6
142	5x48	5x52	at1_off	1.38	0	No	No	No	No	4	3
143	1x44	1x48	at1_off	1.31	0	No	No	No	No	5	4
144	1x56	1x60	at1_off	1.26	0	No	No	Yes	Yes	7	4
145	NT.P19	NT.S16	at1_off	0.89	0	No	Yes	No	No	4	4
146	6x63	6x64	at1_off	0.855	0	Yes	No	No	No	1	2
147	E2.V179	E2x51	at1_off	0.85	0	No	No	No	No	3	5
148	3x54	5x64	at1_off	0.81	0	No	No	No	No	8	5
149	5x61	5x64	at1_off	0.81	0	No	No	No	No	8	5
150	1x55	1x56	at1_off	0.77	0	No	No	No	No	3	7
151	8x47	8x50	at1_off	0.755	0	No	No	No	Yes	8	8
152	7x54	7x55	at1_off	0.755	0	No	No	No	No	7	6
153	5x59	5x63	at1_off	0.75	0	No	No	No	No	3	3
154	I2x51	I2x52	at1_off	0.72	0	No	No	No	No	6	4
155	1x47	2x55	at1_off	0.715	0	Yes	No	No	No	6	4
156	4x48	4x51	at1_off	0.715	0	No	No	No	No	3	4
157	1x52	1x55	at1_off	0.715	0	No	No	No	No	6	3
158	NT.I12	NT.N14	at1_off	0.71	0	No	No	No	No	4	3
159	E2.N174	NT.I12	at1_off	0.71	0	No	No	No	No	0	4
160	3x52	I2x51	at1_off	0.705	0	No	No	No	No	5	6
161	8x57	8x58	at1_off	0.69	0	No	No	No	No	4	6
162	I2x52	I2x54	at1_off	0.62	0	No	No	No	No	4	4
163	8x49	8x52	at1_off	0.62	0	No	No	No	No	6	5
164	2x60	Lig	Shared	27.54	16.21	Yes	Yes	Yes	Yes	7	0
165	3x32	Lig	Shared	15.23	3.93	No	No	Yes	Yes	6	0
166	3x33	Lig	Shared	13.42	5.28	No	No	Yes	Yes	4	0
167	E2x52	Lig	Shared	5.88	6.19	No	Yes	Yes	Yes	4	0
168	7x38	Lig	Shared	9.15	6.41	No	No	Yes	Yes	6	0
169	7x24	NT.C18	Shared	7.28	7.28	No	No	No	No	7	8
170	7x31	NT.A21	Shared	4.63	4.63	No	No	No	No	4	4
171	E1.Y92	NT.R23	Shared	6.175	7.2	Yes	Yes	No	No	4	4
172	1x28	1x30	Shared	9.255	10.89	No	Yes	No	No	4	6
173	1x28	7x28	Shared	10.715	7.56	No	Yes	No	No	4	4
174	1x28	7x32	Shared	7.53	5.48	No	Yes	Yes	No	4	1
175	1x30	1x31	Shared	5.44	7.25	No	No	Yes	No	6	3
176	1x32	2x67	Shared	15.74	16.32	No	No	No	No	4	3
177	1x32	E1.Y92	Shared	6.705	4.13	No	No	Yes	Yes	4	4
178	1x35	1x36	Shared	3.39	3.39	Yes	Yes	No	No	6	5
179	1x35	1x39	Shared	7.25	6.04	Yes	Yes	Yes	Yes	6	7
180	1x35	7x35	Shared	3.39	5.08	Yes	Yes	No	No	6	5
181	1x36	2x65	Shared	3.74	3.74	No	No	No	No	5	3
182	1x39	2x57	Shared	7.615	8.21	Yes	Yes	Yes	Yes	7	8
183	1x39	2x61	Shared	3.335	2.67	Yes	Yes	No	No	7	7
184	1x39	7x39	Shared	5.375	4.03	Yes	Yes	No	No	7	5
185	1x43	1x47	Shared	8.79	5.02	Yes	No	Yes	No	6	6
186	1x43	2x58	Shared	11.555	14.45	Yes	No	No	No	6	9
187	1x46	2x54	Shared	3.42	1.71	No	Yes	No	No	8	6
188	1x49	7x50	Shared	4.06	2.03	No	No	No	No	7	9
189	1x50	2x50	Shared	9.425	6.73	No	No	Yes	Yes	9	9
190	1x50	7x50	Shared	11.4	11.4	No	No	No	No	9	9
191	1x57	2x44	Shared	12.135	4.28	No	No	Yes	No	7	5
192	1x60	8x53	Shared	4.47	10.92	Yes	Yes	No	Yes	4	5
193	2x40	I1x48	Shared	5.365	7.67	Yes	No	No	No	8	5
194	2x40	I1x50	Shared	3.755	3	Yes	No	Yes	No	8	7
195	2x44	I1x50	Shared	4.845	5.54	Yes	No	Yes	No	5	7
196	2x42	3x45	Shared	12.57	4.19	Yes	Yes	No	No	7	7
197	2x42	3x46	Shared	4.875	3.65	Yes	Yes	No	No	7	9
198	2x42	4x45	Shared	4.54	5.19	Yes	Yes	No	No	7	5
199	2x43	3x46	Shared	4.845	2.77	No	No	No	No	8	9
200	2x45	4x46	Shared	11.02	7.87	No	No	No	No	9	7
201	2x45	4x50	Shared	4.52	6.78	No	No	Yes	Yes	9	9
202	2x46	2x50	Shared	4.75	4.07	No	Yes	Yes	Yes	9	9
203	2x50	7x46	Shared	12.115	4.63	Yes	Yes	Yes	No	9	9
204	2x50	7x49	Shared	6.06	6.73	Yes	Yes	No	No	9	9
205	2x53	3x35	Shared	13.29	1.56	Yes	No	No	No	6	8
206	2x56	3x31	Shared	7.995	6.4	No	No	No	No	7	5
207	2x59	E1x52	Shared	11.57	4.87	No	No	Yes	Yes	6	6
208	2x60	2x63	Shared	4.82	3.86	Yes	Yes	Yes	Yes	7	5
209	2x60	3x28	Shared	3.89	3.89	Yes	Yes	No	No	7	6
210	2x62	E1x52	Shared	3.275	2.62	No	No	Yes	Yes	4	6
211	2x63	E1.Y92	Shared	6.45	10.92	Yes	Yes	Yes	Yes	5	4
212	2x63	E1x50	Shared	8.2	10.61	Yes	Yes	Yes	Yes	5	9
213	2x64	E1.Y92	Shared	5.62	7.49	No	No	Yes	Yes	5	4
214	2x66	E1x51	Shared	4.19	3.35	No	No	No	No	5	3
215	E1x49	E2.I177	Shared	10.02	5.01	No	No	No	No	5	1
216	E1x50	E1x52	Shared	12.025	17.04	Yes	Yes	Yes	Yes	9	6
217	3x25	E1x50	Shared	4.57	9.14	No	No	Yes	Yes	9	9
218	E1x50	E2x50	Shared	11.1	15.67	Yes	Yes	No	No	9	9
219	E1x51	E1x52	Shared	13	7.22	No	No	Yes	Yes	3	6
220	3x24	E1x52	Shared	4.26	6.09	No	No	Yes	Yes	5	6
221	3x22	3x26	Shared	4.2	8.39	No	No	No	No	3	6
222	3x22	E2.N168	Shared	9.54	6.81	No	No	No	No	3	3
223	3x22	E2.V169	Shared	5.17	5.91	No	No	No	No	3	5
224	3x25	E2x50	Shared	7.28	7.28	No	No	No	No	9	9
225	3x29	4x65	Shared	13.835	15.81	No	No	No	No	5	5
226	3x32	7x42	Shared	5.05	3.79	No	No	Yes	No	6	7
227	3x33	4x57	Shared	3.26	6.52	No	No	No	No	4	7
228	3x34	4x50	Shared	10.02	7.02	Yes	Yes	Yes	Yes	5	9
229	3x34	4x53	Shared	6.24	2.77	Yes	Yes	No	No	5	8
230	3x36	6x48	Shared	13.67	3.42	No	No	Yes	Yes	7	8
231	3x37	3x41	Shared	3.61	6.19	No	Yes	No	No	7	5
232	3x37	4x56	Shared	9.34	8.01	No	Yes	No	No	7	5
233	3x37	5x43	Shared	3.585	4.78	No	Yes	No	Yes	7	5
234	3x40	5x50	Shared	3.53	3.53	No	No	Yes	Yes	8	8
235	3x42	4x49	Shared	4.28	2.85	No	No	No	No	7	7
236	3x47	5x54	Shared	10.065	4.64	No	No	Yes	No	9	8
237	3x47	5x57	Shared	3.26	4.89	No	No	No	No	9	7
238	3x47	5x58	Shared	11.45	5.09	No	No	Yes	Yes	9	9
239	3x51	3x52	Shared	3.52	3.52	Yes	Yes	No	No	8	5
240	3x51	3x55	Shared	11.36	11.36	Yes	Yes	No	No	8	7
241	3x51	3x56	Shared	7.08	8.71	Yes	Yes	No	No	8	6
242	3x51	5x60	Shared	5.275	8.21	Yes	Yes	No	No	8	3
243	3x54	5x61	Shared	11.775	4.42	No	No	No	No	8	8
244	3x55	3x56	Shared	7.61	11.07	No	No	No	No	7	6
245	E2.F171	E2.T178	Shared	4.54	2.59	No	No	No	No	6	4
246	E2.I172	E2.V179	Shared	5.375	3.07	No	No	No	No	5	3
247	E2.Y184	E2x52	Shared	12.895	4.13	No	Yes	No	Yes	4	4
248	6x62	E2.Y184	Shared	9.585	12.4	No	No	No	Yes	3	4
249	5x47	6x45	Shared	4.285	6.43	Yes	Yes	Yes	Yes	8	5
250	5x47	6x52	Shared	13.47	10.54	Yes	Yes	No	No	8	8
251	5x51	6x45	Shared	23.045	9.65	No	No	Yes	Yes	6	5
252	5x58	6x37	Shared	4.235	3.63	Yes	Yes	Yes	No	9	7
253	5x58	6x41	Shared	10.095	5.05	Yes	Yes	No	No	9	8
254	5x62	5x66	Shared	6.38	3.48	No	Yes	No	No	5	5
255	5x62	6x34	Shared	4.01	10.02	No	Yes	No	Yes	5	6
256	5x62	6x38	Shared	5.235	4.65	No	Yes	No	No	5	4
257	6x31	6x32	Shared	8.65	10.65	No	No	No	No	4	7
258	6x39	7x52	Shared	8.32	2.77	No	No	Yes	No	5	8
259	6x43	6x47	Shared	7.265	3.96	No	Yes	No	No	6	8
260	6x43	7x48	Shared	9.135	7.31	No	Yes	No	No	6	6
261	6x43	7x52	Shared	4.29	11.79	No	Yes	Yes	No	6	8
262	6x44	6x48	Shared	8.015	5.01	Yes	No	Yes	Yes	9	8
263	6x49	6x50	Shared	3.39	5.08	No	Yes	No	No	5	9
264	6x51	6x55	Shared	5.475	6.85	No	Yes	No	No	6	6
265	6x51	7x37	Shared	8.895	8.21	No	Yes	No	No	6	7
266	6x51	7x38	Shared	9.28	3.98	No	Yes	No	No	6	6
267	6x54	7x33	Shared	7.625	8.32	No	No	No	No	5	5
268	6x56	6x60	Shared	6.09	6.09	No	No	No	No	5	3
269	6x57	7x30	Shared	5.215	2.98	No	No	Yes	No	5	4
270	6x60	E3.I270	Shared	4.28	5.71	No	No	No	No	3	2
271	6x60	E3.I271	Shared	3.57	4.28	No	No	No	No	3	1
272	6x61	7x30	Shared	4.61	4.61	No	No	Yes	No	2	4
273	7x26	E3.I271	Shared	5.89	4.42	No	No	No	No	1	1
274	7x23	7x25	Shared	4.165	4.76	No	No	No	No	4	2
275	E2.E185	E2.H183	Shared	4.31	4.92	No	No	No	Yes	5	3
276	5x44	6x52	Shared	5.94	3.96	No	No	No	No	4	8
277	3x30	4x62	Shared	3.25	4.87	No	No	No	No	5	5
278	E2.I177	E2.T175	Shared	3.04	9.12	No	No	No	No	1	0
279	3x48	5x53	Shared	2.94	2.94	No	No	No	No	6	7
280	6x49	6x53	Shared	2.94	4.42	No	Yes	No	No	5	6
281	5x49	5x50	Shared	2.885	1.44	Yes	No	Yes	Yes	6	8
282	1x42	2x57	Shared	2.85	2.85	No	No	Yes	Yes	7	8
283	6x38	6x42	Shared	2.825	2.83	No	No	No	No	4	5
284	3x21	E1x50	Shared	2.81	2.81	No	No	Yes	Yes	8	9
285	3x44	5x50	Shared	2.625	3.5	No	No	Yes	Yes	7	8
286	6x50	7x37	Shared	2.625	3.5	No	No	No	No	9	7
287	1x53	2x47	Shared	2.545	1.7	No	Yes	No	No	9	8
288	2x41	4x42	Shared	2.545	5.09	Yes	Yes	No	No	6	7
289	1x43	2x57	Shared	2.435	3.65	Yes	No	Yes	Yes	6	8
290	3x41	4x52	Shared	2.435	3.65	No	No	No	No	5	4
291	2x37	2x40	Shared	2.4	4.8	No	No	Yes	No	8	8
292	1x38	7x39	Shared	2.38	6.35	No	No	No	No	5	5
293	3x44	5x53	Shared	2.28	6.08	No	No	No	No	7	7
294	3x34	4x54	Shared	2.26	3.01	Yes	Yes	No	No	5	3
295	E2.F170	E2.H183	Shared	2.26	3.39	No	No	No	Yes	3	3
296	6x59	6x63	Shared	2.235	1.49	No	No	Yes	No	4	1
297	6x36	7x56	Shared	2.14	4.28	No	No	No	No	8	7
298	5x36	E2.Y184	Shared	2.085	4.17	No	No	No	Yes	3	4
299	5x461	5x50	Shared	2.03	4.06	No	No	Yes	Yes	5	8
300	5x51	5x55	Shared	1.825	6.09	No	No	No	No	6	5
301	7x32	NT.G22	Shared	1.82	1.82	Yes	No	No	No	1	2
302	4x59	4x60	Shared	1.64	3.28	No	No	No	No	4	6
303	4x38	4x41	Shared	1.585	3.17	No	No	No	No	7	4
304	1x41	1x45	Shared	1.54	1.54	No	No	No	No	5	5
305	4x44	4x48	Shared	1.54	3.07	No	No	No	No	3	3
306	2x41	4x39	Shared	1.52	1.52	Yes	Yes	No	No	6	1
307	2x41	4x43	Shared	1.52	4.55	Yes	Yes	No	No	6	3
308	5x55	5x59	Shared	1.475	2.95	No	No	No	No	5	3
309	1x35	7x36	Shared	1.47	2.94	Yes	Yes	Yes	No	6	6
310	1x55	1x59	Shared	1.255	3.77	No	No	No	No	3	4
311	1x58	1x59	Shared	1.03	7.22	No	No	No	No	4	4
312	NT.C18	NT.P19	Shared	0.94	1.88	No	No	No	Yes	8	4
313	1x47	1x51	Shared	0.775	1.55	Yes	No	No	No	6	3
314	3x56	I2x50	Shared	0.765	1.53	No	No	No	No	6	8
315	4x40	4x44	Shared	0.745	1.49	No	No	No	No	4	3
316	E2.V169	NT.I11	at1_on	0	4.61	No	No	No	No	5	0
317	NT.I14	NT.K12	at1_on	0	5.82	No	No	No	No	0	0
318	E2.F170	NT.K12	at1_on	0	6.2	No	No	No	No	3	0
319	E2.F171	NT.R13	at1_on	0	8.55	No	No	No	No	6	0
320	E2.E173	NT.R13	at1_on	0	4.65	No	No	No	No	0	0
321	E2.F170	NT.I14	at1_on	0	10.05	No	No	No	No	3	0
322	E2.H183	NT.I14	at1_on	0	13.26	No	Yes	No	No	3	0
323	E2.E173	NT.Q15	at1_on	0	7.65	No	No	No	No	0	0
324	E2.N174	NT.Q15	at1_on	0	3.96	No	No	No	No	0	0
325	NT.D16	NT.P19	at1_on	0	6.44	No	No	No	Yes	0	4
326	Lig	NT.D16	at1_on	0	7.24	Yes	Yes	No	No	0	0
327	Lig	NT.D17	at1_on	0	4.21	Yes	Yes	No	No	0	6
328	E2.N174	NT.P19	at1_on	0	3.26	No	No	No	Yes	0	4
329	Lig	NT.R23	at1_on	0	3.76	Yes	Yes	No	No	0	4
330	1x28	1x31	at1_on	0	5.3	No	Yes	Yes	No	4	3
331	1x39	7x38	at1_on	0	6.04	Yes	Yes	No	No	7	6
332	1x52	7x55	at1_on	0	3.65	No	No	No	No	6	6
333	1x52	8x54	at1_on	0	6.09	No	No	No	No	6	7
334	1x53	7x50	at1_on	0	3.53	No	Yes	No	No	9	9
335	1x56	8x50	at1_on	0	3.93	No	No	No	Yes	7	8
336	1x56	8x53	at1_on	0	3.79	No	No	No	Yes	7	5
337	1x60	8x56	at1_on	0	7.89	Yes	Yes	No	No	4	3
338	1x60	8x57	at1_on	0	8.21	Yes	Yes	No	No	4	4
339	1x60	8x60	at1_on	0	3.97	Yes	Yes	No	No	4	0
340	I1x49	I1x51	at1_on	0	5.75	No	No	No	No	5	7
341	2x42	3x49	at1_on	0	9.55	Yes	Yes	No	No	7	8
342	2x45	3x42	at1_on	0	4.12	No	No	No	No	9	7
343	2x46	3x43	at1_on	0	5.54	No	Yes	No	No	9	8
344	2x46	7x49	at1_on	0	4.12	No	Yes	No	No	9	9
345	2x46	7x53	at1_on	0	3.52	No	Yes	No	Yes	9	9
346	2x50	3x39	at1_on	0	5.89	Yes	Yes	No	No	9	9
347	2x52	3x35	at1_on	0	6.3	No	No	No	No	7	8
348	2x56	2x59	at1_on	0	4.42	No	No	No	No	7	6
349	2x56	2x60	at1_on	0	4.85	No	No	Yes	Yes	7	7
350	2x57	7x42	at1_on	0	8.21	Yes	Yes	Yes	No	8	7
351	2x63	Lig	at1_on	0	4.84	Yes	Yes	Yes	Yes	5	0
352	2x67	E1x49	at1_on	0	10.47	No	No	No	No	3	5
353	E1.Y92	Lig	at1_on	0	10.64	Yes	Yes	Yes	Yes	4	0
354	3x33	4x61	at1_on	0	3.42	No	No	No	No	4	4
355	3x34	3x35	at1_on	0	4.83	Yes	Yes	No	No	5	8
356	3x36	7x42	at1_on	0	7.03	No	No	Yes	No	7	7
357	3x36	Lig	at1_on	0	4.87	No	No	Yes	Yes	7	0
358	3x37	5x42	at1_on	0	4.99	No	Yes	No	No	7	3
359	3x37	Lig	at1_on	0	4.13	No	Yes	Yes	Yes	7	0
360	3x38	4x50	at1_on	0	6.48	No	No	Yes	Yes	7	9
361	3x40	6x48	at1_on	0	4.9	No	No	Yes	Yes	8	8
362	3x43	7x53	at1_on	0	5.86	No	No	No	Yes	8	9
363	3x45	4x49	at1_on	0	3.27	No	No	No	No	7	7
364	3x49	I2x57	at1_on	0	10.72	No	No	No	Yes	8	6
365	3x50	5x58	at1_on	0	8.23	Yes	No	Yes	Yes	9	9
366	3x50	7x53	at1_on	0	7.2	Yes	No	No	Yes	9	9
367	3x51	5x61	at1_on	0	3.63	Yes	Yes	No	No	8	8
368	3x52	I2x57	at1_on	0	3.64	No	No	No	Yes	5	6
369	3x53	I2x57	at1_on	0	5.53	No	No	No	Yes	8	6
370	3x55	5x64	at1_on	0	5.09	No	No	No	No	7	5
371	I2x53	I2x57	at1_on	0	6.59	No	No	No	Yes	6	6
372	4x64	5x36	at1_on	0	4.58	No	No	No	No	4	3
373	4x65	E2x52	at1_on	0	17.1	No	No	No	Yes	5	4
374	E2.V169	E2x50	at1_on	0	5.12	No	No	No	No	5	9
375	E2.F171	E2.N176	at1_on	0	3.62	No	No	No	No	6	0
376	E2.E173	E2.N174	at1_on	0	3.94	No	No	No	No	0	0
377	E2.V179	Lig	at1_on	0	4.67	No	No	Yes	Yes	3	0
378	E2x51	Lig	at1_on	0	4.95	No	No	Yes	Yes	5	0
379	5x39	E2x52	at1_on	0	4.87	No	No	No	Yes	5	4
380	E2.H183	Lig	at1_on	0	16	No	Yes	Yes	Yes	3	0
381	E2.Y184	Lig	at1_on	0	12.09	No	Yes	Yes	Yes	4	0
382	E2.E185	E2.S189	at1_on	0	4.31	No	No	No	No	5	0
383	E2.N188	E2.Q187	at1_on	0	13.2	No	No	No	No	0	0
384	5x36	E2.S189	at1_on	0	8.91	No	No	No	No	3	0
385	6x62	E2.S189	at1_on	0	5.78	No	No	No	No	3	0
386	5x37	6x62	at1_on	0	6.86	No	No	No	No	2	3
387	5x43	6x51	at1_on	0	7.86	No	Yes	No	Yes	5	6
388	5x43	6x55	at1_on	0	10.51	No	Yes	No	No	5	6
389	5x43	Lig	at1_on	0	24.77	No	Yes	Yes	Yes	5	0
390	5x44	6x56	at1_on	0	3.62	No	No	No	No	4	5
391	5x47	6x49	at1_on	0	3.77	Yes	Yes	No	Yes	8	5
392	5x54	6x44	at1_on	0	5.02	Yes	No	Yes	No	8	9
393	5x58	6x40	at1_on	0	4.84	Yes	Yes	No	No	9	8
394	5x62	6x37	at1_on	0	5.87	No	Yes	Yes	No	5	7
395	5x65	6x34	at1_on	0	4.87	No	No	No	Yes	8	6
396	5x66	6x34	at1_on	0	8.69	No	No	No	Yes	5	6
397	6x28	I3.Y226	at1_on	0	5.56	No	No	No	Yes	0	0
398	6x30	I3.Y226	at1_on	0	6.98	Yes	No	No	Yes	6	0
399	6x33	I3.Y226	at1_on	0	4.84	No	No	No	Yes	7	0
400	6x29	I3.K232	at1_on	0	3.71	No	No	No	No	0	0
401	6x28	6x30	at1_on	0	6.52	No	No	Yes	No	0	6
402	6x30	6x34	at1_on	0	6.04	Yes	No	No	Yes	6	6
403	6x33	6x34	at1_on	0	3.77	No	No	No	Yes	7	6
404	6x40	7x53	at1_on	0	8.46	No	No	No	Yes	8	9
405	6x43	7x45	at1_on	0	6.04	No	Yes	No	No	6	9
406	6x45	6x46	at1_on	0	10.72	Yes	Yes	No	No	5	6
407	6x45	6x49	at1_on	0	7.54	Yes	Yes	No	Yes	5	5
408	6x47	7x45	at1_on	0	8.94	No	No	No	No	8	9
409	6x48	6x52	at1_on	0	3.29	Yes	Yes	No	No	8	8
410	6x48	7x45	at1_on	0	7.91	Yes	Yes	No	No	8	9
411	6x50	7x40	at1_on	0	5.08	No	No	No	No	9	8
412	6x51	7x34	at1_on	0	3.94	No	Yes	No	No	6	4
413	6x51	Lig	at1_on	0	7.92	No	Yes	Yes	Yes	6	0
414	6x58	Lig	at1_on	0	14.05	No	No	Yes	Yes	4	0
415	6x61	E3.I271	at1_on	0	5.89	No	No	No	No	2	1
416	6x61	Lig	at1_on	0	5.01	No	No	Yes	Yes	2	0
417	7x24	7x27	at1_on	0	3.61	No	No	No	No	7	3
418	7x26	7x29	at1_on	0	4.42	No	No	No	No	1	1
419	7x28	7x32	at1_on	0	4.34	No	No	Yes	No	4	1
420	7x31	Lig	at1_on	0	22.07	No	No	Yes	Yes	4	0
421	7x34	Lig	at1_on	0	13.98	No	No	Yes	Yes	4	0
422	7x35	Lig	at1_on	0	7.63	No	No	Yes	Yes	5	0
423	7x40	7x43	at1_on	0	5.02	No	No	No	No	8	5
424	7x49	7x53	at1_on	0	3.49	No	No	No	Yes	9	9
425	7x55	8x50	at1_on	0	5.36	No	No	No	Yes	6	8
426	8x49	8x53	at1_on	0	9.55	No	No	No	Yes	6	5
427	8x50	8x53	at1_on	0	4.13	No	Yes	No	Yes	8	5
428	8x52	8x53	at1_on	0	11.32	No	No	No	Yes	5	5
429	8x52	8x56	at1_on	0	8.18	No	No	No	No	5	3
430	8x53	8x56	at1_on	0	4.51	No	Yes	No	No	5	3
431	Lig	Lig	at1_on	0	29.98	Yes	Yes	Yes	Yes	0	0
432	1x59	1x60	at1_on	0	3.09	No	No	Yes	Yes	4	4
433	1x53	1x57	at1_on	0	3.07	No	Yes	No	No	9	7
434	7x54	8x50	at1_on	0	3.01	No	No	No	Yes	7	8
435	5x42	5x46	at1_on	0	2.95	No	No	No	No	3	4
436	1x31	1x35	at1_on	0	2.94	Yes	No	Yes	Yes	3	6
437	4x62	4x63	at1_on	0	2.94	No	No	No	No	5	4
438	6x36	6x40	at1_on	0	2.94	No	No	No	No	8	8
439	1x34	1x35	at1_on	0	2.92	No	No	Yes	Yes	4	6
440	E2.E185	E2.S186	at1_on	0	2.87	No	No	No	No	5	0
441	1x47	2x51	at1_on	0	2.85	Yes	No	No	No	6	7
442	3x54	5x65	at1_on	0	2.85	No	No	No	No	8	8
443	5x61	5x65	at1_on	0	2.85	No	No	No	No	8	8
444	2x44	2x48	at1_on	0	2.77	Yes	No	No	No	5	5
445	3x41	4x53	at1_on	0	2.77	No	No	No	No	5	8
446	6x31	6x35	at1_on	0	2.77	No	No	No	No	4	5
447	7x51	7x56	at1_on	0	2.77	No	No	No	No	6	7
448	1x53	7x55	at1_on	0	2.62	No	Yes	No	No	9	6
449	2x38	2x42	at1_on	0	2.62	No	No	Yes	Yes	7	7
450	2x38	I2x57	at1_on	0	2.62	No	No	No	Yes	7	6
451	2x49	4x50	at1_on	0	2.59	No	No	Yes	Yes	8	9
452	6x54	7x37	at1_on	0	2.59	No	No	No	No	5	7
453	4x64	5x35	at1_on	0	2.57	No	No	No	No	4	1
454	7x25	7x26	at1_on	0	2.51	No	No	No	No	2	1
455	5x47	5x48	at1_on	0	2.44	Yes	Yes	No	No	8	4
456	5x62	5x63	at1_on	0	2.32	No	Yes	No	No	5	3
457	1x46	7x47	at1_on	0	1.96	No	Yes	No	No	8	8
458	1x45	1x46	at1_on	0	1.84	No	No	No	Yes	5	8
459	5x40	6x59	at1_on	0	1.84	No	No	No	No	5	4
460	2x41	4x46	at1_on	0	1.71	Yes	Yes	No	No	6	7
461	3x30	4x57	at1_on	0	1.71	No	No	No	No	5	7
462	5x39	5x40	at1_on	0	1.71	No	No	No	No	5	5
463	1x46	1x50	at1_on	0	1.7	No	Yes	No	No	8	9
464	1x54	2x47	at1_on	0	1.7	No	No	No	No	7	8
465	2x37	2x39	at1_on	0	1.68	No	No	No	No	8	7
466	NT.K20	NT.P19	at1_on	0	1.67	No	No	No	Yes	6	4
467	4x60	5x39	at1_on	0	1.64	No	No	No	No	6	5
468	4x41	4x45	at1_on	0	1.59	No	No	No	No	4	5
469	1x40	1x41	at1_on	0	1.55	No	No	No	No	5	5
470	1x37	1x41	at1_on	0	1.52	No	No	No	No	6	5
471	2x38	4x39	at1_on	0	1.52	No	No	No	No	7	1
472	1x48	1x49	at1_on	0	1.51	No	No	No	No	4	7
473	E2.N188	E2.S186	at1_on	0	1.49	No	No	No	No	0	0
474	4x38	4x40	at1_on	0	1.47	No	No	No	No	7	4
475	4x47	4x48	at1_on	0	1.47	No	No	No	No	4	3
476	5x56	5x60	at1_on	0	1.47	No	No	No	No	4	3
477	5x67	I3.I228	at1_on	0	1.45	No	No	No	No	4	0
478	8x55	8x59	at1_on	0	1.41	No	No	No	No	3	0
479	8x55	8x58	at1_on	0	1.38	No	No	No	No	3	6
480	I3.E227	I3.I228	at1_on	0	1.37	No	No	No	No	0	0
481	I3.I228	I3.Q229	at1_on	0	1.37	No	No	No	No	0	0
482	5x68	I3.Y226	at1_on	0	1.33	No	No	No	Yes	0	0
483	I3.N231	I3.Q229	at1_on	0	1.32	No	No	No	No	0	0
484	I2x51	I2x54	at1_on	0	1.24	No	No	No	No	6	4
485	3x52	I2x56	at1_on	0	1.21	No	No	No	No	5	4
486	I2x55	I2x56	at1_on	0	1.21	No	No	No	No	4	4
487	6x29	6x31	at1_on	0	1.19	No	No	No	No	0	4
488	8x59	8x60	at1_on	0	1.19	No	No	No	No	0	0

Orange: nodes, hubs and links specific of at1_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of at1_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	at1_off Avg Int. Strength	at1_on Avg Int. Strength	at1_off Num Of Links	at1_on Num Of Links	ConSurf
1	1x31	at1_off	3.3125	5.16333	4	3	3
2	1x43	at1_off	6.18625	7.70667	4	3	6
3	1x47	at1_off	3.64	3.14	4	3	6
4	I1x50	at1_off	3.843	4.27	5	2	7
5	2x40	at1_off	3.8475	5.15667	4	3	8
6	2x44	at1_off	6.78875	4.19667	4	3	5
7	2x53	at1_off	10.975	1.56	5	1	6
8	3x50	at1_off	4.67	7.715	4	2	9
9	5x49	at1_off	5.36	1.44	4	1	6
10	5x54	at1_off	6.4225	4.83	4	2	8
11	6x30	at1_off	6.25125	6.51333	4	3	6
12	6x37	at1_off	5.23125	4.75	4	2	7
13	6x44	at1_off	6.75	5.015	5	2	9
14	6x63	at1_off	2.735	1.49	4	1	1
15	7x30	at1_off	3.657	3.795	5	2	4
16	7x32	at1_off	4.38	3.88	4	3	1
17	7x36	at1_off	2.56	2.94	4	1	6
18	7x42	at1_off	7.492	6.34333	5	3	7
19	7x46	at1_off	11.6112	4.63	4	1	9
20	7x52	at1_off	5.16	7.28	4	2	8
21	Lig	Shared	11.481	10.8324	10	25	0
22	1x35	Shared	4.772	3.885	5	6	6
23	1x39	Shared	6.714	5.398	5	5	7
24	1x60	Shared	2.54625	6.816	4	5	4
25	2x41	Shared	1.955	3.2175	4	4	6
26	2x42	Shared	5.929	5.04	5	5	7
27	2x50	Shared	8.0875	5.61	4	5	9
28	2x57	Shared	4.9	5.73	4	4	8
29	2x60	Shared	9.1275	7.2025	6	4	7
30	2x63	Shared	5.65625	7.5575	4	4	5
31	E1.Y92	Shared	5.685	8.076	5	5	4
32	E1x50	Shared	7.49071	11.054	7	5	9
33	E1x52	Shared	8.826	7.568	5	5	6
34	3x34	Shared	4.918	4.4075	5	4	5
35	3x51	Shared	6.338	7.086	5	5	8
36	4x50	Shared	4.87875	5.7175	4	4	9
37	5x47	Shared	7.2375	5.795	4	4	8
38	5x50	Shared	2.7675	3.1325	4	4	8
39	5x58	Shared	7.3525	5.368	4	5	9
40	6x45	Shared	8.179	8.585	5	4	5
41	6x48	Shared	9.66125	4.906	4	5	8
42	NT.P19	at1_on	0.915	3.3125	2	4	4
43	1x28	at1_on	9.16667	7.3075	3	4	4
44	1x46	at1_on	3.42	1.8025	1	4	8
45	1x53	at1_on	7.265	2.73	2	4	9
46	2x46	at1_on	3.76	4.3125	2	4	9
47	3x37	at1_on	5.51167	5.62	3	5	7
48	I2x57	at1_on	4.8	5.82	1	5	6
49	E2x52	at1_on	11.1617	8.0725	3	4	4
50	E2.H183	at1_on	3.285	9.3925	2	4	3
51	E2.Y184	at1_on	8.18833	8.1975	3	4	4
52	5x43	at1_on	3.1	11.98	2	4	5
53	5x62	at1_on	5.20833	5.268	3	5	5
54	I3.Y226	at1_on	0	4.6775	0	4	0
55	6x34	at1_on	6.4025	6.678	2	5	6
56	6x43	at1_on	6.89667	7.275	3	4	6
57	6x49	at1_on	2.94667	5.2025	3	4	5
58	6x51	at1_on	7.88333	6.46	3	6	6
59	7x53	at1_on	7.945	5.706	3	5	9
60	8x50	at1_on	1.41	4.1075	2	4	8
61	8x53	at1_on	4.58	7.37	2	6	5

Orange: nodes, hubs and links specific of at1_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of at1_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	at1_off Recurrence	at1_on Recurrence	at1_off Hub1?	at1_on Hub1?	at1_off Hub2?	at1_on Hub2?	ConSurf1	ConSurf2
1	1x39	Lig	at1_off	66.4486	0	Yes	Yes	Yes	Yes	7	0
2	3x33	Lig	at1_off	30.6204	6.32137	No	No	Yes	Yes	4	0
3	7x42	Lig	at1_off	91.7749	0	Yes	No	Yes	Yes	7	0
4	E2x52	Lig	at1_off	38.6944	8.94285	No	Yes	Yes	Yes	4	0
5	E2.Y184	E2x52	at1_off	32.3944	0.173624	No	Yes	No	Yes	4	4
6	6x62	E2.Y184	at1_off	27.4951	3.12767	No	No	No	Yes	3	4
7	6x58	6x62	at1_off	26.3783	0	No	No	No	No	4	3
8	6x58	7x30	at1_off	23.8855	0	No	No	Yes	No	4	4
9	6x61	7x30	at1_off	15.574	2.12506	No	No	Yes	No	2	4
10	6x61	7x27	at1_off	14.1672	0	No	No	No	No	2	3
11	7x27	NT.C18	at1_off	12.7541	0	No	No	No	No	3	8
12	1x35	1x39	at1_off	68.4571	0.777639	Yes	Yes	Yes	Yes	6	7
13	1x28	1x30	at1_off	28.3682	0.00733622	No	Yes	No	No	4	6
14	1x30	1x31	at1_off	30.2656	1.05397	No	No	Yes	No	6	3
15	1x31	7x35	at1_off	35.0754	0	Yes	No	No	No	3	5
16	1x28	7x32	at1_off	28.8341	2.12017	No	Yes	Yes	No	4	1
17	1x31	7x32	at1_off	32.6289	0	Yes	No	Yes	No	3	1
18	1x31	7x36	at1_off	31.6632	0	Yes	No	Yes	No	3	6
19	1x35	7x36	at1_off	35.9856	1.06375	Yes	Yes	Yes	No	6	6
20	1x28	7x28	at1_off	53.349	1.05886	No	Yes	No	No	4	4
21	1x39	2x57	at1_off	16.3453	5.14758	Yes	Yes	Yes	Yes	7	8
22	1x43	2x57	at1_off	15.1297	8.32416	Yes	No	Yes	Yes	6	8
23	2x53	2x57	at1_off	21.5747	0	Yes	No	Yes	Yes	6	8
24	2x53	7x46	at1_off	31.6416	0	Yes	No	Yes	No	6	9
25	2x50	7x46	at1_off	40.419	2.55545	Yes	Yes	Yes	No	9	9
26	6x48	7x42	at1_off	83.485	0	Yes	Yes	Yes	No	8	7
27	3x43	6x44	at1_off	32.6042	0	No	No	Yes	No	8	9
28	3x43	6x41	at1_off	32.1538	0	No	No	No	No	8	8
29	5x58	6x41	at1_off	64.1132	1.02952	Yes	Yes	No	No	9	8
30	3x46	6x37	at1_off	44.1706	0	No	No	Yes	No	9	7
31	2x43	3x46	at1_off	24.1261	1.6482	No	No	No	No	8	9
32	2x43	7x53	at1_off	21.1952	0	No	No	No	Yes	8	9
33	6x44	6x45	at1_off	91.1085	0	Yes	No	Yes	Yes	9	5
34	6x41	6x45	at1_off	33.5051	0	No	No	Yes	Yes	8	5
35	5x54	6x45	at1_off	54.6386	0	Yes	No	Yes	Yes	8	5
36	5x54	5x58	at1_off	35.7727	0	Yes	No	Yes	Yes	8	9
37	3x33	4x57	at1_off	29.6085	4.233	No	No	No	No	4	7
38	3x34	4x57	at1_off	28.8063	0	Yes	Yes	No	No	5	7
39	2x45	4x46	at1_off	22.9692	5.92522	No	No	No	No	9	7
40	2x42	4x46	at1_off	22.9784	0	Yes	Yes	No	No	7	7
41	2x42	4x42	at1_off	32.6381	0	Yes	Yes	No	No	7	7
42	2x41	4x42	at1_off	31.3023	1.09799	Yes	Yes	No	No	6	7
43	2x41	I1x50	at1_off	27.2576	0	Yes	Yes	Yes	No	6	7
44	1x58	I1x50	at1_off	17.5238	0	No	No	Yes	No	4	7
45	1x58	1x59	at1_off	16.2157	2.55789	No	No	No	No	4	4
46	1x55	1x59	at1_off	14.8027	2.55789	No	No	No	No	3	4
47	1x55	1x56	at1_off	11.9582	0	No	No	No	No	3	7
48	1x56	1x60	at1_off	10.5266	0	No	No	Yes	Yes	7	4
49	3x50	6x37	at1_off	56.9741	0	Yes	No	Yes	No	9	7
50	3x49	3x50	at1_off	18.1656	0	No	No	Yes	No	8	9
51	2x38	3x49	at1_off	13.0226	0	No	No	No	No	7	8
52	2x42	3x46	at1_off	27.7265	3.29396	Yes	Yes	No	No	7	9
53	7x45	7x46	at1_off	26.7917	0	No	No	Yes	No	9	9
54	7x45	7x49	at1_off	24.0582	0	No	No	No	No	9	9
55	2x60	Lig	at1_off	41.8505	4.99597	Yes	Yes	Yes	Yes	7	0
56	2x60	E1x50	at1_off	11.2208	0	Yes	Yes	Yes	Yes	7	9
57	2x60	2x63	at1_off	25.6163	0.20786	Yes	Yes	Yes	Yes	7	5
58	2x63	E2.V179	at1_off	24.376	0	Yes	Yes	No	No	5	3
59	E2.I172	E2.V179	at1_off	22.0313	1.06375	No	No	No	No	5	3
60	E2.I172	E2.I177	at1_off	20.7417	0	No	No	No	No	5	1
61	E1x49	E2.I177	at1_off	18.3846	2.1544	No	No	No	No	5	1
62	E1x49	E2.T178	at1_off	16.0059	0	No	No	No	No	5	4
63	E2.T178	E2.V169	at1_off	13.3588	0	No	No	No	No	4	5
64	3x22	E2.V169	at1_off	12.026	3.20348	No	No	No	No	3	5
65	2x46	3x42	at1_off	34.8379	0	No	Yes	No	No	9	7
66	3x42	4x49	at1_off	32.1538	7.68102	No	No	No	No	7	7
67	3x41	4x49	at1_off	29.4635	0	No	No	No	No	5	7
68	3x44	5x54	at1_off	14.4757	0	No	No	Yes	No	7	8
69	3x44	5x50	at1_off	11.227	3.07877	No	No	Yes	Yes	7	8
70	3x47	5x57	at1_off	12.3932	1.05886	No	No	No	No	9	7
71	3x50	6x30	at1_off	34.5078	0	Yes	No	Yes	No	9	6
72	3x51	5x57	at1_off	11.335	0	Yes	Yes	No	No	8	7
73	3x54	6x30	at1_off	21.4081	0	No	No	Yes	No	8	6
74	3x54	5x61	at1_off	15.9967	0.141834	No	No	No	No	8	8
75	3x41	4x52	at1_off	16.4533	1.09799	No	No	No	No	5	4
76	4x48	4x52	at1_off	13.726	0	No	No	No	No	3	4
77	5x61	6x34	at1_off	13.3064	0	No	No	No	Yes	8	6
78	6x36	7x53	at1_off	12.3562	0	No	No	No	Yes	8	9
79	6x40	7x49	at1_off	11.7669	0	No	No	No	No	8	9
80	7x38	Lig	at1_off	11.48	6.87893	No	No	Yes	Yes	6	0
81	6x51	7x38	at1_off	10.1472	0.838774	No	Yes	No	No	6	6
82	7x25	7x28	at1_off	49.909	0	No	No	No	No	2	4
83	7x23	7x25	at1_off	42.1713	1.05642	No	No	No	No	4	2
84	7x23	7x26	at1_off	38.2933	0	No	No	No	No	4	1
85	7x26	E3.I271	at1_off	34.409	4.20365	No	No	No	No	1	1
86	6x60	E3.I271	at1_off	30.5186	1.42323	No	No	No	No	3	1
87	6x60	E3.I270	at1_off	22.7193	1.0662	No	No	No	No	3	2
88	6x63	E3.I270	at1_off	18.8104	0	Yes	No	No	No	1	2
89	2x38	4x38	at1_off	10.5976	0	No	No	No	No	7	7
90	2x63	E1.Y92	at1_off	12.0168	0.39371	Yes	Yes	Yes	Yes	5	4
91	2x53	7x42	at1_off	16.3484	0	Yes	No	Yes	No	6	7
92	6x44	7x45	at1_off	43.5042	0	Yes	No	No	No	9	9
93	1x35	7x35	Shared	32.4006	10.7304	Yes	Yes	No	No	6	5
94	1x50	2x50	Shared	10.9925	100	No	No	Yes	Yes	9	9
95	6x44	6x48	Shared	83.8367	94.3927	Yes	No	Yes	Yes	9	8
96	5x58	6x37	Shared	100	39.9139	Yes	Yes	Yes	No	9	7
97	3x34	4x50	Shared	25.3818	16.8342	Yes	Yes	Yes	Yes	5	9
98	2x45	4x50	Shared	23.4875	14.2885	No	No	Yes	Yes	9	9
99	2x46	2x50	Shared	37.5158	53.5911	No	Yes	Yes	Yes	9	9
100	2x50	7x49	Shared	17.3881	53.4639	Yes	Yes	No	No	9	9
101	3x37	3x41	Shared	10.4588	23.7229	No	Yes	No	No	7	5
102	3x47	5x54	Shared	10.8259	94.6715	No	No	Yes	No	9	8
103	5x62	6x34	Shared	10.5883	35.2897	No	Yes	No	Yes	5	6
104	2x63	E1x50	at1_on	3.08518	14.4744	Yes	Yes	Yes	Yes	5	9
105	2x63	Lig	at1_on	0	14.939	Yes	Yes	Yes	Yes	5	0
106	E2.H183	Lig	at1_on	0	10.2071	No	Yes	Yes	Yes	3	0
107	NT.D16	NT.P19	at1_on	0	12.4691	No	No	No	Yes	0	4
108	Lig	NT.D16	at1_on	0	13.4766	Yes	Yes	No	No	0	0
109	7x35	Lig	at1_on	0	11.5521	No	No	Yes	Yes	5	0
110	2x57	7x42	at1_on	0	11.2244	Yes	Yes	Yes	No	8	7
111	3x36	7x42	at1_on	0	10.4199	No	No	Yes	No	7	7
112	3x36	Lig	at1_on	0	80.9845	No	No	Yes	Yes	7	0
113	2x46	7x53	at1_on	0	54.5986	No	Yes	No	Yes	9	9
114	3x50	7x53	at1_on	0	55.2784	Yes	No	No	Yes	9	9
115	3x50	5x58	at1_on	0	55.6257	Yes	No	Yes	Yes	9	9
116	3x47	5x58	at1_on	2.61623	95.0089	No	No	Yes	Yes	9	9
117	5x54	6x44	at1_on	0	94.5174	Yes	No	Yes	No	8	9
118	3x36	6x48	at1_on	1.5827	86.3326	No	No	Yes	Yes	7	8
119	7x49	7x53	at1_on	0	54.5815	No	No	No	Yes	9	9
120	6x40	7x53	at1_on	0	55.99	No	No	No	Yes	8	9
121	5x58	6x40	at1_on	0	57.4646	Yes	Yes	No	No	9	8
122	1x50	7x50	at1_on	5.50705	80.965	No	No	No	No	9	9
123	1x53	7x55	at1_on	0	46.8882	No	Yes	No	No	9	6
124	1x53	7x50	at1_on	0	73.7461	No	Yes	No	No	9	9
125	1x60	8x53	at1_on	3.88733	22.1529	Yes	Yes	No	Yes	4	5
126	8x50	8x53	at1_on	0	32.1767	No	Yes	No	Yes	8	5
127	7x55	8x50	at1_on	0	39.6718	No	No	No	Yes	6	8
128	1x53	1x57	at1_on	0	20.3238	No	Yes	No	No	9	7
129	1x57	2x44	at1_on	0.0555333	17.8001	No	No	Yes	No	7	5
130	2x40	I1x50	at1_on	4.40255	10.1998	Yes	No	Yes	No	8	7
131	2x44	I1x50	at1_on	2.85996	12.7381	Yes	No	Yes	No	5	7
132	3x34	4x53	at1_on	1.27418	21.0892	Yes	Yes	No	No	5	8
133	3x41	4x53	at1_on	0	21.9671	No	No	No	No	5	8
134	3x37	Lig	at1_on	0	25.6156	No	Yes	Yes	Yes	7	0
135	2x42	4x45	at1_on	1.47472	11.3345	Yes	Yes	No	No	7	5
136	2x38	I2x57	at1_on	0	13.1734	No	No	No	Yes	7	6
137	3x51	5x61	at1_on	0	27.2125	Yes	Yes	No	No	8	8
138	5x61	5x65	at1_on	0	27.8458	No	No	No	No	8	8
139	5x65	6x34	at1_on	0	29.4647	No	No	No	Yes	8	6
140	5x62	6x37	at1_on	0	39.2268	No	Yes	Yes	No	5	7
141	3x52	I2x57	at1_on	0	21.2066	No	No	No	Yes	5	6
142	6x48	6x52	at1_on	0	13.2688	Yes	Yes	No	No	8	8
143	1x46	1x50	at1_on	0	17.8001	No	Yes	No	No	8	9
144	1x45	1x46	at1_on	0	10.1998	No	No	No	Yes	5	8
145	3x51	3x52	at1_on	5.95132	21.7935	Yes	Yes	No	No	8	5

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
1x39	Lig	at1_off	9.995	0	0	0	1	0
2x60	Lig	Shared	27.54	16.21	1	1	1	0
3x29	Lig	at1_off	3.345	0	1	0	1	0
3x32	Lig	Shared	15.23	3.93	1	1	1	0
3x33	Lig	Shared	13.42	5.28	0	1	1	0
4x65	Lig	at1_off	24.47	0	1	0	1	0
E2x52	Lig	Shared	5.88	6.19	0	1	1	0
7x38	Lig	Shared	9.15	6.41	0	1	1	0
7x42	Lig	at1_off	3.76	0	1	0	1	0
NT.K20	NT.R23	at1_off	6.19	0	0	0	2	1
7x31	NT.A21	Shared	4.63	4.63	0	1	1	2
1x32	NT.R23	at1_off	5.34	0	1	0	2	1
E1.Y92	NT.R23	Shared	6.175	7.2	1	1	1	1
1x32	E1.Y92	Shared	6.705	4.13	1	0	2	1
1x35	1x39	Shared	7.25	6.04	0	0	2	1
1x35	2x64	at1_off	8.36	0	0	0	2	2
1x35	7x35	Shared	3.39	5.08	0	0	2	1
1x39	2x57	Shared	7.615	8.21	0	0	1	2
1x39	2x61	Shared	3.335	2.67	0	0	1	2
1x39	7x39	Shared	5.375	4.03	0	0	1	2
2x53	2x57	at1_off	6.7	0	1	0	2	2
2x53	3x32	at1_off	6.55	0	1	0	2	1
2x53	3x35	Shared	13.29	1.56	1	0	2	2
2x53	7x42	at1_off	14.44	0	1	0	2	1
2x60	2x63	Shared	4.82	3.86	1	1	1	1
2x60	E1x50	at1_off	10.31	0	1	1	1	2
2x60	3x28	Shared	3.89	3.89	1	1	1	2
2x60	3x29	at1_off	4.94	0	1	1	1	1
2x60	E2x50	at1_off	3.265	0	1	1	1	2
2x63	E1.Y92	Shared	6.45	10.92	1	1	1	1
2x63	E1x50	Shared	8.2	10.61	1	1	1	2
2x64	E1.Y92	Shared	5.62	7.49	0	0	2	1
7x35	E1.Y92	at1_off	3.475	0	0	1	1	1
E1x50	E2x50	Shared	11.1	15.67	1	1	2	2
3x29	4x65	Shared	13.835	15.81	1	0	1	1
3x32	7x42	Shared	5.05	3.79	1	1	1	1
3x33	4x57	Shared	3.26	6.52	0	1	1	2
3x35	7x42	at1_off	6.975	0	1	0	2	1
3x36	6x48	Shared	13.67	3.42	0	1	1	2
3x37	3x41	Shared	3.61	6.19	0	1	1	2
3x37	4x56	Shared	9.34	8.01	0	1	1	2
3x37	5x43	Shared	3.585	4.78	0	1	1	1
4x64	E2x52	at1_off	14.71	0	0	0	2	1
E2.I172	E2.V179	Shared	5.375	3.07	0	0	2	1
E2.Y184	E2x52	Shared	12.895	4.13	0	1	1	1
6x62	E2.Y184	Shared	9.585	12.4	0	0	2	1
6x48	7x42	at1_off	7.235	0	0	0	2	1
6x51	6x55	Shared	5.475	6.85	0	1	1	2
6x51	7x37	Shared	8.895	8.21	0	1	1	2
6x51	7x38	Shared	9.28	3.98	0	1	1	1
6x58	6x62	at1_off	9.14	0	0	0	1	2
6x58	7x34	at1_off	5.545	0	0	0	1	1
6x61	7x30	Shared	4.61	4.61	0	1	1	2
E2.E185	E2.H183	Shared	4.31	4.92	0	0	2	1
6x61	7x27	at1_off	3.25	0	0	1	1	2
2x63	E2.V179	at1_off	3.155	0	1	1	1	1
E3.R272	NT.D17	at1_off	2.98	0	0	0	2	1
6x58	7x30	at1_off	2.92	0	0	0	1	2
7x30	7x31	at1_off	2.92	0	0	0	2	1
5x40	5x43	at1_off	2.615	0	0	0	2	1
1x31	7x35	at1_off	2.54	0	4	4	2	1
E2.F170	E2.H183	Shared	2.26	3.39	0	1	2	1
5x36	E2.Y184	Shared	2.085	4.17	0	0	2	1
4x61	Lig	at1_off	2.02	0	0	0	1	0
3x30	4x61	at1_off	1.79	0	0	0	2	1
2x56	3x28	at1_off	1.68	0	0	0	2	2
5x39	5x42	at1_off	1.475	0	0	0	2	2
NT.D17	NT.S16	at1_off	1.47	0	0	0	1	2
NT.P19	NT.S16	at1_off	0.89	0	0	0	2	2
E2.V179	E2x51	at1_off	0.85	0	0	1	1	1
E2.F170	NT.I14	at1_on	0	10.05	0	1	2	2
E2.H183	NT.I14	at1_on	0	13.26	0	1	1	2
NT.D16	NT.P19	at1_on	0	6.44	0	1	1	2
Lig	NT.D16	at1_on	0	7.24	1	1	0	1
Lig	NT.D17	at1_on	0	4.21	1	1	0	1
Lig	NT.R23	at1_on	0	3.76	1	1	0	1
1x39	7x38	at1_on	0	6.04	0	0	1	1
2x56	2x60	at1_on	0	4.85	0	0	2	1
2x57	7x42	at1_on	0	8.21	0	0	2	1
2x63	Lig	at1_on	0	4.84	1	1	1	0
E1.Y92	Lig	at1_on	0	10.64	1	1	1	0
3x33	4x61	at1_on	0	3.42	0	1	1	1
3x36	7x42	at1_on	0	7.03	0	1	1	1
3x36	Lig	at1_on	0	4.87	0	1	1	0
3x37	5x42	at1_on	0	4.99	0	1	1	2
3x37	Lig	at1_on	0	4.13	0	1	1	0
4x64	5x36	at1_on	0	4.58	0	0	2	2
4x65	E2x52	at1_on	0	17.1	1	0	1	1
E2.V179	Lig	at1_on	0	4.67	0	1	1	0
E2x51	Lig	at1_on	0	4.95	0	0	1	0
5x39	E2x52	at1_on	0	4.87	0	0	2	1
E2.H183	Lig	at1_on	0	16	0	1	1	0
E2.Y184	Lig	at1_on	0	12.09	0	1	1	0
5x43	6x51	at1_on	0	7.86	0	1	1	1
5x43	6x55	at1_on	0	10.51	0	1	1	2
5x43	Lig	at1_on	0	24.77	0	1	1	0
6x51	7x34	at1_on	0	3.94	0	1	1	1
6x51	Lig	at1_on	0	7.92	0	1	1	0
6x58	Lig	at1_on	0	14.05	0	0	1	0
6x61	E3.I271	at1_on	0	5.89	0	1	1	2
6x61	Lig	at1_on	0	5.01	0	1	1	0
7x31	Lig	at1_on	0	22.07	0	1	1	0
7x34	Lig	at1_on	0	13.98	0	1	1	0
7x35	Lig	at1_on	0	7.63	0	1	1	0
1x31	1x35	at1_on	0	2.94	4	4	2	2
3x30	4x57	at1_on	0	1.71	0	0	2	2
5x39	5x40	at1_on	0	1.71	0	0	2	2
NT.K20	NT.P19	at1_on	0	1.67	0	0	2	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	at1_off	4YAY-AT₁-ZD-7155 4ZUD-AT₁-Olmesartan
	at1_on	7F6G-AT₁-SAR1-AngII-Gq/β1/γ2

Network Difference
Value	at1_off	at1_on
I_min	3.255	3.26
Number of Linked Nodes	281	289
Number of Specific Nodes	21 (7.47%)	29 (10.03%)
Number of Shared Nodes	260 (92.53%)	260 (89.97%)
Number of Links	315	325
Number of Specific Links	163 (51.75%)	173 (53.23%)
Number of Shared Links	152 (48.25%)	152 (46.77%)
Number of Hubs	41	41
Number of Specific Hubs	20 (48.78%)	20 (48.78%)
Number of Shared Hubs	21 (51.22%)	21 (51.22%)
Average % Shared Neighbours (Jaccard)	33.55
Average % Shared Neighbours (Otsuka)	42.57
Average % Shared Neighbours (Overlap Coefficient)	52.06
Average % Shared Cliques (k3-6)	76.00
Graphlets Similarity	0.598439

Paths Difference
Value	at1_off	at1_on
Number Of Nodes in MetaPath	96	53
Specific Nodes in MetaPath	63 (65.63%)	20 (37.74%)
Shared Nodes in MetaPath	260 (92.53%)	260 (92.53%)
Number Of Links MetaPath	103	53
Specific Links in MetaPath	92 (89.32%)	42 (79.25%)
Shared Links in MetaPath	152 (48.25%)	152 (48.25%)
Number of Shortest Paths	82438	77451
Length Of Smallest Path	3	3
Average Path Length	15.111	15.2114
Length of Longest Path	35	33
Minimum Path Strength	0.71	1.21
Average Path Strength	6.3654	5.55632
Maximum Path Strength	21.385	23.42
Minimum Path Correlation	0.7	0.7
Average Path Correlation	0.911833	0.934926
Maximum Path Correlation	0.985	1
Minimum % Of Corr. Nodes	3.0303	4.34783
Average % Of Corr. Nodes	36.3259	50.1002
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	47.8199	41.8676
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

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