Orange: nodes, hubs and links specific of at1_on_gp network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of at1_off network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.


Index Hub Owner at1_on_gp Avg Int. Strength at1_off Avg Int. Strength at1_on_gp Num Of Links at1_off Num Of Links ConSurf
1NT.I14 at1_on_gp8.01750403
2NT.P19 at1_on_gp3.31250.915424
31x28 at1_on_gp7.30759.16667434
41x46 at1_on_gp1.80253.42418
51x50 at1_on_gp5.6458.085439
61x53 at1_on_gp2.737.265429
71x57 at1_on_gp3.286.76167437
82x46 at1_on_gp4.31253.76429
93x36 at1_on_gp4.57513.67417
103x37 at1_on_gp5.625.51167537
11I2x57 at1_on_gp5.878334.8616
124x65 at1_on_gp9.67519.1525425
13E2.I172 at1_on_gp2.96255.6325425
14E2x52 at1_on_gp8.072511.1617434
15E2.H183 at1_on_gp8.0383.285523
16E2.Y184 at1_on_gp8.19758.18833434
175x43 at1_on_gp11.983.1425
185x62 at1_on_gp5.2685.20833535
195x65 at1_on_gp3.3556.865418
20I3.Y226 at1_on_gp4.67750404
21I3.Q229 at1_on_gp5.43250403
226x33 at1_on_gp3.9352.94417
236x34 at1_on_gp6.6786.4025526
246x43 at1_on_gp7.2756.89667436
256x49 at1_on_gp5.20252.94667435
266x51 at1_on_gp6.467.88333636
277x34 at1_on_gp5.96255.545414
287x37 at1_on_gp4.32755.76427
297x38 at1_on_gp4.83759.215426
307x49 at1_on_gp4.27258.71333439
317x53 at1_on_gp5.251677.945639
328x50 at1_on_gp7.6361.41528
338x53 at1_on_gp7.374.58625
34G.HN.43 at1_on_gp3.34750409
35G.S1.02 at1_on_gp6.1750405
36G.S1.05 at1_on_gp5.9650409
37G.S1.06 at1_on_gp3.1550408
38G.S1.07 at1_on_gp4.3750409
39G.s1h1.04 at1_on_gp6.50509
40G.H1.04 at1_on_gp7.30407
41G.H1.08 at1_on_gp4.250509
42G.h1ha.04 at1_on_gp4.9540507
43H.HA.07 at1_on_gp4.98750405
44H.HA.16 at1_on_gp6.9660504
45H.HA.19 at1_on_gp4.168330606
46H.HA.22 at1_on_gp5.3840506
47H.HA.23 at1_on_gp5.10750405
48H.HA.26 at1_on_gp6.28750407
49H.HA.29 at1_on_gp5.19250406
50H.hahb.04 at1_on_gp4.26250406
51H.hahb.06 at1_on_gp6.573330604
52H.hahb.08 at1_on_gp6.3780503
53H.HB.02 at1_on_gp7.090505
54H.HB.10 at1_on_gp6.170401
55H.hbhc.14 at1_on_gp4.5780504
56H.HC.10 at1_on_gp5.98250407
57H.HC.11 at1_on_gp11.52170608
58H.hchd.01 at1_on_gp6.5250608
59H.HD.03 at1_on_gp4.6120506
60H.HD.07 at1_on_gp10.07750404
61H.hdhe.01 at1_on_gp8.3550406
62H.hdhe.03 at1_on_gp6.72250407
63H.HE.02 at1_on_gp4.0340507
64H.HE.04 at1_on_gp10.1150609
65H.HE.05 at1_on_gp7.0120506
66H.HE.06 at1_on_gp8.6850406
67H.HE.09 at1_on_gp2.4550405
68H.HE.11 at1_on_gp8.7440508
69H.HE.12 at1_on_gp3.87250406
70H.hehf.04 at1_on_gp6.911670608
71H.hehf.06 at1_on_gp5.0750409
72H.HF.03 at1_on_gp8.6480509
73H.HF.05 at1_on_gp4.1350408
74H.HF.06 at1_on_gp9.35250406
75G.S2.06 at1_on_gp6.79750408
76G.S3.02 at1_on_gp6.150404
77G.S3.03 at1_on_gp5.36250407
78G.S3.05 at1_on_gp5.360407
79G.S3.07 at1_on_gp5.930409
80G.S3.08 at1_on_gp4.233330609
81G.H2.02 at1_on_gp4.36250408
82G.H2.04 at1_on_gp5.7460509
83G.H2.06 at1_on_gp5.250609
84G.H2.07 at1_on_gp6.1580509
85G.H2.08 at1_on_gp5.19250408
86G.H2.09 at1_on_gp5.81750408
87G.H2.10 at1_on_gp4.73250407
88G.h2s4.01 at1_on_gp5.040609
89G.S4.03 at1_on_gp3.63250407
90G.S4.06 at1_on_gp3.98250407
91G.s4h3.03 at1_on_gp7.710507
92G.s4h3.04 at1_on_gp6.506670608
93G.s4h3.05 at1_on_gp7.3240509
94G.s4h3.06 at1_on_gp9.57250409
95G.H3.01 at1_on_gp9.4250409
96G.H3.02 at1_on_gp4.88250408
97G.H3.06 at1_on_gp4.9060507
98G.H3.09 at1_on_gp6.5680509
99G.H3.12 at1_on_gp4.6540507
100G.H3.15 at1_on_gp5.350708
101G.H3.17 at1_on_gp6.210405
102G.H3.18 at1_on_gp6.0380509
103G.S5.02 at1_on_gp3.3350406
104G.S5.03 at1_on_gp4.03250408
105G.S5.05 at1_on_gp5.292860709
106G.S5.06 at1_on_gp5.6850408
107G.HG.08 at1_on_gp2.2360506
108G.HG.15 at1_on_gp5.5460506
109G.hgh4.02 at1_on_gp4.337140708
110G.hgh4.05 at1_on_gp8.39750406
111G.H4.10 at1_on_gp8.180407
112G.H4.11 at1_on_gp2.91750408
113G.H4.14 at1_on_gp7.45750405
114G.H4.15 at1_on_gp6.5640509
115G.h4s6.13 at1_on_gp3.95250407
116G.S6.02 at1_on_gp6.261670608
117G.S6.05 at1_on_gp7.480505
118G.H5.03 at1_on_gp6.8540508
119G.H5.14 at1_on_gp4.230506
120G.H5.20 at1_on_gp3.560408
121G.H5.23 at1_on_gp6.146670604
122G.H5.25 at1_on_gp5.98250408
123b.lhb1x6 at1_on_gp4.6440503
124b.lhb1x11 at1_on_gp4.790404
125b.b1x6 at1_on_gp7.0940509
126b.l1x3 at1_on_gp7.575710709
127b.b2x1 at1_on_gp8.9960508
128b.b2x5 at1_on_gp6.451670607
129b.b3x2 at1_on_gp5.71250405
130b.b3x3 at1_on_gp5.05750408
131b.l3x2 at1_on_gp7.63250409
132b.b4x2 at1_on_gp5.140508
133b.b4x3 at1_on_gp3.711670607
134b.b4x5 at1_on_gp4.9250407
135b.b4x6 at1_on_gp8.754290709
136b.b5x3 at1_on_gp6.017140709
137b.b5x5 at1_on_gp5.0150405
138b.b5x7 at1_on_gp5.62250407
139b.l5x1 at1_on_gp4.06750408
140b.l5x5 at1_on_gp6.09250809
141b.b6x3 at1_on_gp2.97750408
142b.b6x5 at1_on_gp4.656670606
143b.b7x1 at1_on_gp4.2020504
144b.b7x2 at1_on_gp3.75750408
145b.l7x2 at1_on_gp4.130409
146b.b8x1 at1_on_gp3.340408
147b.b8x3 at1_on_gp3.6550406
148b.b8x4 at1_on_gp5.1650606
149b.l8x1 at1_on_gp4.03250405
150b.b9x4 at1_on_gp5.91750409
151b.l9x3 at1_on_gp6.823330609
152b.l9x6 at1_on_gp6.678330608
153b.b10x3 at1_on_gp3.390608
154b.b10x5 at1_on_gp4.3680509
155b.b11x2 at1_on_gp4.3580507
156b.b11x4 at1_on_gp4.90609
157b.l11x1 at1_on_gp3.380409
158b.l11x2 at1_on_gp8.750409
159b.b12x2 at1_on_gp5.17750407
160b.b12x6 at1_on_gp7.673330608
161b.b13x7 at1_on_gp8.2420507
162b.l13x3 at1_on_gp6.660709
163b.l13x6 at1_on_gp5.5140509
164b.b15x1 at1_on_gp6.516670609
165b.b15x2 at1_on_gp7.19750406
166b.l15x1 at1_on_gp3.96750407
167b.l15x2 at1_on_gp6.0550409
168b.b16x4 at1_on_gp9.4340506
169b.b16x5 at1_on_gp5.1150405
170b.b16x6 at1_on_gp7.9950608
171b.b17x4 at1_on_gp8.450405
172b.b17x7 at1_on_gp8.84750408
173b.l17x3 at1_on_gp8.775710709
174b.l17x6 at1_on_gp6.990609
175b.b18x3 at1_on_gp5.09750408
176b.l18x1 at1_on_gp5.742860706
177b.l18x2 at1_on_gp6.0150407
178b.b19x2 at1_on_gp7.8960506
179b.b19x4 at1_on_gp5.89750408
180b.l19x2 at1_on_gp6.0280509
181b.b20x2 at1_on_gp3.7020506
182b.b20x4 at1_on_gp9.628570708
183b.b20x6 at1_on_gp6.668330606
184b.l20x2 at1_on_gp7.88250409
185b.b21x1 at1_on_gp10.79750407
186b.b21x6 at1_on_gp4.58250401
187b.b21x7 at1_on_gp5.340605
188b.l21x5 at1_on_gp3.6460504
189b.b22x5 at1_on_gp6.35250407
190b.b23x2 at1_on_gp4.74750406
191b.b23x6 at1_on_gp6.564290707
192b.l23x1 at1_on_gp9.0150406
193b.b24x3 at1_on_gp4.070505
194b.b24x4 at1_on_gp7.870506
195b.b24x5 at1_on_gp3.120405
196b.b24x7 at1_on_gp8.5050409
197b.l24x2 at1_on_gp3.370406
198b.b25x3 at1_on_gp7.750405
199b.l25x3 at1_on_gp9.320409
200b.b26x3 at1_on_gp4.070406
201b.b27x3 at1_on_gp4.2080508
202b.l27x1 at1_on_gp11.42670609
203b.l27x2 at1_on_gp10.640409
204b.b28x3 at1_on_gp4.780407
205b.b28x4 at1_on_gp6.1140506
206b.b28x6 at1_on_gp7.2560509
207g.h1x11 at1_on_gp3.350509
208g.l1x5 at1_on_gp4.08250404
209g.h2x11 at1_on_gp9.10250406
210g.ctx3 at1_on_gp7.690409
211g.ctx6 at1_on_gp4.1040506
212g.ctx15 at1_on_gp6.8950409
213g.ctx16 at1_on_gp5.244290708
2141x31 Shared4.63253.3125443
2151x35 Shared3.764294.772756
2161x39 Shared4.961676.714657
2171x60 Shared6.8162.54625544
2182x41 Shared3.21751.955446
2192x42 Shared4.6655.929657
2202x50 Shared5.618.0875549
2212x57 Shared5.734.9448
2222x60 Shared6.3629.1275567
2232x63 Shared7.55755.65625445
224E1.Y92 Shared7.193335.685654
225E1x50 Shared9.661677.49071679
226E1x52 Shared7.5688.826556
2273x34 Shared4.0544.918555
2283x50 Shared10.02754.67449
2293x51 Shared7.0866.338558
2304x50 Shared5.71754.87875449
2315x47 Shared5.7957.2375448
2325x50 Shared3.13252.7675448
2335x58 Shared4.977.3525649
2346x44 Shared3.96756.75459
2356x45 Shared8.5858.179455
2366x48 Shared4.9069.66125548
2377x32 Shared3.674.38441
238Lig Shared10.522711.48126100
2391x43 at1_off7.706676.18625346
2401x47 at1_off3.143.64346
241I1x50 at1_off3.796673.843357
2422x40 at1_off5.156673.8475348
2432x44 at1_off4.196676.78875345
2442x53 at1_off1.5610.975156
2455x49 at1_off1.445.36146
2465x54 at1_off4.233336.4225348
2476x30 at1_off6.513336.25125346
2486x37 at1_off4.755.23125247
2496x63 at1_off1.492.735141
2507x30 at1_off3.7953.657254
2517x36 at1_off2.942.56146
2527x42 at1_off6.343337.492357
2537x46 at1_off4.6311.6112149
2547x52 at1_off7.285.16248
   
Orange: nodes, hubs and links specific of at1_on_gp network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of at1_off network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Owner at1_on_gp Recurrence at1_off Recurrence at1_on_gp Hub1? at1_off Hub1? at1_on_gp Hub2? at1_off Hub2? ConSurf1 ConSurf2
13x50 5x58 at1_on_gp27.11860YesYesYesYes99
23x47 5x58 at1_on_gp26.25422.61623NoNoYesYes99
35x54 6x44 at1_on_gp24.96180NoYesYesYes89
43x36 6x48 at1_on_gp20.59211.5827YesNoYesYes78
53x36 Lig at1_on_gp19.85640YesNoYesYes70
63x50 G.H5.25 at1_on_gp41.06690YesYesYesNo98
7G.H5.20 G.H5.25 at1_on_gp51.53520YesNoYesNo88
8G.H5.17 G.H5.20 at1_on_gp54.61670NoNoYesNo58
9G.H5.13 G.H5.17 at1_on_gp57.43120NoNoNoNo75
10G.H5.13 G.S6.02 at1_on_gp57.5050NoNoYesNo78
11G.H5.10 G.S6.02 at1_on_gp58.98630NoNoYesNo78
12G.H5.10 G.S5.03 at1_on_gp59.11580NoNoYesNo78
13G.S5.03 G.S5.05 at1_on_gp60.73510YesNoYesNo89
14G.S5.05 G.s6h5.01 at1_on_gp54.76470YesNoNoNo99
15G.S5.07 G.s6h5.01 at1_on_gp94.5160NoNoNoNo99
16G.S5.07 G.s5hg.01 at1_on_gp97.96220NoNoNoNo99
17G.s5hg.01 H.hdhe.05 at1_on_gp49.00960NoNoNoNo98
18G.s1h1.04 H.hdhe.05 at1_on_gp49.04920YesNoNoNo98
19G.s1h1.04 G.s4h3.06 at1_on_gp48.99410YesNoYesNo99
20G.s4h3.05 G.s4h3.06 at1_on_gp98.49780YesNoYesNo99
21G.s4h3.04 G.s4h3.05 at1_on_gp98.47730YesNoYesNo89
22G.HG.15 G.s4h3.04 at1_on_gp98.70660YesNoYesNo68
23G.HG.15 G.hgh4.02 at1_on_gp97.52570YesNoYesNo68
24G.H3.02 G.hgh4.02 at1_on_gp97.42540YesNoYesNo88
25G.H3.02 G.H4.15 at1_on_gp97.31730YesNoYesNo89
26G.H3.09 G.H4.15 at1_on_gp99.11040YesNoYesNo99
27G.H3.09 G.S4.04 at1_on_gp1000YesNoNoNo99
28G.H3.12 G.S4.04 at1_on_gp41.83840YesNoNoNo79
29G.H3.12 G.H3.15 at1_on_gp14.64090YesNoYesNo78
30G.H3.15 G.H3.17 at1_on_gp14.47160YesNoYesNo85
31G.H2.09 G.H3.17 at1_on_gp14.34630YesNoYesNo85
32G.H2.09 b.l27x1 at1_on_gp14.3830YesNoYesNo89
33b.b26x1 b.l27x1 at1_on_gp11.18380NoNoYesNo99
34b.b26x1 b.b26x2 at1_on_gp11.12890NoNoNoNo97
35b.b26x2 b.b2x3 at1_on_gp11.03260NoNoNoNo76
36b.b2x3 b.b2x5 at1_on_gp10.98450NoNoYesNo67
37G.s4h3.02 G.s5hg.01 at1_on_gp49.05430NoNoNoNo99
38G.s4h3.02 G.s4h3.03 at1_on_gp49.17310NoNoYesNo97
39G.s4h3.03 G.s4h3.06 at1_on_gp49.11730YesNoYesNo79
40G.S1.07 G.S4.04 at1_on_gp58.17280YesNoNoNo99
41G.S1.07 G.S3.08 at1_on_gp56.55540YesNoYesNo99
42G.H5.02 G.s6h5.05 at1_on_gp43.91960NoNoNoNo49
43G.H5.01 G.H5.02 at1_on_gp43.63830NoNoNoNo94
44G.H1.11 G.H5.01 at1_on_gp43.49760NoNoNoNo89
45G.H1.07 G.H1.11 at1_on_gp43.35680NoNoNoNo98
46G.H1.07 H.HF.05 at1_on_gp43.2160NoNoYesNo98
47G.H5.03 G.s6h5.05 at1_on_gp40.48050YesNoNoNo89
48H.HF.02 H.HF.05 at1_on_gp41.16870NoNoYesNo68
49H.HE.04 H.HF.02 at1_on_gp16.85850YesNoNoNo96
50H.HF.02 H.HF.06 at1_on_gp24.16870NoNoYesNo66
51H.HE.01 H.HF.06 at1_on_gp23.58180NoNoYesNo96
52H.HE.01 H.hdhe.04 at1_on_gp23.49560NoNoNoNo97
53H.HE.02 H.hdhe.04 at1_on_gp23.35020YesNoNoNo77
54H.HE.02 H.hdhe.03 at1_on_gp12.130YesNoYesNo77
55H.HA.26 H.hahb.04 at1_on_gp10.23050YesNoYesNo76
56G.S3.08 G.s3h2.03 at1_on_gp27.07550YesNoNoNo99
57G.H2.02 G.s3h2.03 at1_on_gp27.02870YesNoNoNo89
58G.H2.02 b.l9x6 at1_on_gp40.59370YesNoYesNo88
59b.l11x1 b.l9x6 at1_on_gp26.04190YesNoYesNo98
60G.H2.07 G.S3.08 at1_on_gp27.26650YesNoYesNo99
61G.H2.02 G.H2.07 at1_on_gp54.20730YesNoYesNo89
62G.H2.04 G.H3.12 at1_on_gp27.14460YesNoYesNo97
63G.H2.04 G.H2.07 at1_on_gp27.40740YesNoYesNo99
64G.H2.02 b.l13x6 at1_on_gp40.46270YesNoYesNo89
65b.l11x1 b.l13x6 at1_on_gp25.18140YesNoYesNo99
66G.H2.06 b.l9x6 at1_on_gp17.29080YesNoYesNo98
67G.H2.06 b.l17x6 at1_on_gp16.65430YesNoYesNo99
68b.l13x6 b.l15x1 at1_on_gp15.98280YesNoYesNo97
69b.l15x1 b.l17x6 at1_on_gp15.77720YesNoYesNo79
70b.b11x6 b.l11x1 at1_on_gp49.73780NoNoYesNo99
71b.b11x6 b.l9x3 at1_on_gp47.32660NoNoYesNo99
72b.b11x4 b.l9x3 at1_on_gp31.99630YesNoYesNo99
73b.b10x3 b.b11x4 at1_on_gp24.4920YesNoYesNo89
74b.b10x3 b.b6x2 at1_on_gp24.80380YesNoNoNo88
75b.b10x2 b.b6x2 at1_on_gp24.53560NoNoNoNo68
76b.b10x2 b.b14x3 at1_on_gp19.86720NoNoNoNo65
77b.b14x3 b.b15x1 at1_on_gp19.20660NoNoYesNo59
78b.b15x1 b.b16x6 at1_on_gp12.5910YesNoYesNo98
79b.l17x5 b.l17x6 at1_on_gp31.82530NoNoYesNo69
80b.l17x5 b.l19x2 at1_on_gp31.52490NoNoYesNo69
81b.l17x3 b.l19x2 at1_on_gp18.23680YesNoYesNo99
82b.b19x4 b.l17x3 at1_on_gp11.44120YesNoYesNo89
83b.b17x7 b.b20x6 at1_on_gp14.84330YesNoYesNo86
84b.b17x7 b.b21x1 at1_on_gp12.37560YesNoYesNo87
85b.b20x4 b.b20x6 at1_on_gp13.91640YesNoYesNo86
86b.b10x5 b.b11x2 at1_on_gp12.08590YesNoYesNo97
87b.b12x6 b.l9x3 at1_on_gp12.67840YesNoYesNo89
883x50 7x53 at1_on_gp14.10910YesYesYesNo99
89G.H5.03 G.s6h5.01 at1_on_gp39.64890YesNoNoNo89
901x50 2x50 Shared12.196510.9925YesNoYesYes99
913x47 5x54 Shared25.970410.8259NoNoNoYes98
926x44 6x48 Shared22.510983.8367YesYesYesYes98
931x39 Lig at1_off2.6006666.4486YesYesYesYes70
943x33 Lig at1_off0.56491830.6204NoNoYesYes40
957x42 Lig at1_off091.7749NoYesYesYes70
96E2x52 Lig at1_off1.5153838.6944YesNoYesYes40
97E2.Y184 E2x52 at1_off0.0035722232.3944YesNoYesNo44
986x62 E2.Y184 at1_off0.4565727.4951NoNoYesNo34
996x58 6x62 at1_off026.3783NoNoNoNo43
1006x58 7x30 at1_off023.8855NoNoNoYes44
1016x61 7x30 at1_off0.3048215.574NoNoNoYes24
1026x61 7x27 at1_off014.1672NoNoNoNo23
1037x27 NT.C18 at1_off012.7541NoNoNoNo38
1041x35 1x39 at1_off1.8311468.4571YesYesYesYes67
1051x35 7x35 at1_off1.8067632.4006YesYesNoNo65
1061x28 1x30 at1_off8.43832e-0528.3682YesNoNoNo46
1071x30 1x31 at1_off0.30355530.2656NoNoYesYes63
1081x31 7x35 at1_off035.0754YesYesNoNo35
1091x28 7x32 at1_off8.43832e-0528.8341YesNoYesYes41
1101x31 7x32 at1_off0.91060832.6289YesYesYesYes31
1111x31 7x36 at1_off031.6632YesYesNoYes36
1121x35 7x36 at1_off0.30363935.9856YesYesNoYes66
1131x28 7x28 at1_off0.30355553.349YesNoNoNo44
1141x39 2x57 at1_off0.26288216.3453YesYesYesYes78
1151x43 2x57 at1_off0.85407115.1297NoYesYesYes68
1162x53 2x57 at1_off021.5747NoYesYesYes68
1172x53 7x46 at1_off031.6416NoYesNoYes69
1182x50 7x46 at1_off0.2977640.419YesYesNoYes99
1196x48 7x42 at1_off083.485YesYesNoYes87
1203x43 6x44 at1_off032.6042NoNoYesYes89
1213x43 6x41 at1_off032.1538NoNoNoNo88
1225x58 6x41 at1_off0.15290264.1132YesYesNoNo98
1235x58 6x37 at1_off0.231013100YesYesNoYes97
1243x46 6x37 at1_off044.1706NoNoNoYes97
1252x43 3x46 at1_off0.15520924.1261NoNoNoNo89
1262x43 7x53 at1_off021.1952NoNoYesNo89
1276x44 6x45 at1_off091.1085YesYesYesYes95
1286x41 6x45 at1_off033.5051NoNoYesYes85
1295x54 6x45 at1_off054.6386NoYesYesYes85
1305x54 5x58 at1_off035.7727NoYesYesYes89
1313x33 4x57 at1_off0.55541129.6085NoNoNoNo47
1323x34 4x57 at1_off1.1081828.8063YesYesNoNo57
1333x34 4x50 at1_off2.2529825.3818YesYesYesYes59
1342x45 4x50 at1_off2.6803823.4875NoNoYesYes99
1352x45 4x46 at1_off2.9575822.9692NoNoNoNo97
1362x42 4x46 at1_off3.5251422.9784YesYesNoNo77
1372x42 4x42 at1_off032.6381YesYesNoNo77
1382x41 4x42 at1_off0.30363931.3023YesYesNoNo67
1392x41 I1x50 at1_off027.2576YesYesNoYes67
1401x58 I1x50 at1_off017.5238NoNoNoYes47
1411x58 1x59 at1_off0.30046116.2157NoNoNoNo44
1421x55 1x59 at1_off0.30046114.8027NoNoNoNo34
1431x55 1x56 at1_off011.9582NoNoNoNo37
1441x56 1x60 at1_off010.5266NoNoYesYes74
1453x50 6x37 at1_off056.9741YesYesNoYes97
1463x49 3x50 at1_off018.1656NoNoYesYes89
1472x38 3x49 at1_off013.0226NoNoNoNo78
1482x42 3x46 at1_off0.3103927.7265YesYesNoNo79
1492x46 2x50 at1_off6.5267137.5158YesNoYesYes99
1502x50 7x49 at1_off6.5267117.3881YesYesYesNo99
1517x45 7x46 at1_off026.7917NoNoNoYes99
1527x45 7x49 at1_off024.0582NoNoYesNo99
1532x60 Lig at1_off1.2124741.8505YesYesYesYes70
1542x60 E1x50 at1_off011.2208YesYesYesYes79
1552x60 2x63 at1_off0.002334625.6163YesYesYesYes75
1562x63 E2.V179 at1_off024.376YesYesNoNo53
157E2.I172 E2.V179 at1_off0.45507922.0313YesNoNoNo53
158E2.I172 E2.I177 at1_off020.7417YesNoNoNo51
159E1x49 E2.I177 at1_off0.0020814518.3846NoNoNoNo51
160E1x49 E2.T178 at1_off016.0059NoNoNoNo54
161E2.T178 E2.V169 at1_off013.3588NoNoNoNo45
1623x22 E2.V169 at1_off0.46028212.026NoNoNoNo35
1632x46 3x42 at1_off034.8379YesNoNoNo97
1643x42 4x49 at1_off0.15954132.1538NoNoNoNo77
1653x41 4x49 at1_off029.4635NoNoNoNo57
1663x37 3x41 at1_off0.035609710.4588YesNoNoNo75
1673x44 5x54 at1_off0.8991614.4757NoNoNoYes78
1683x44 5x50 at1_off0.45640111.227NoNoYesYes78
1693x47 5x57 at1_off0.15281812.3932NoNoNoNo97
1703x50 6x30 at1_off034.5078YesYesNoYes96
1713x51 5x57 at1_off011.335YesYesNoNo87
1723x54 6x30 at1_off021.4081NoNoNoYes86
1733x54 5x61 at1_off1.4323515.9967NoNoNoNo88
1743x41 4x52 at1_off0.15293116.4533NoNoNoNo54
1754x48 4x52 at1_off013.726NoNoNoNo34
1765x61 6x34 at1_off013.3064NoNoYesNo86
1775x62 6x34 at1_off1.1792810.5883YesNoYesNo56
1786x36 7x53 at1_off012.3562NoNoYesNo89
1796x40 7x49 at1_off011.7669NoNoYesNo89
1807x38 Lig at1_off0.14927411.48YesNoYesYes60
1816x51 7x38 at1_off0.020139510.1472YesNoYesNo66
1827x25 7x28 at1_off049.909NoNoNoNo24
1837x23 7x25 at1_off0.15231242.1713NoNoNoNo42
1847x23 7x26 at1_off038.2933NoNoNoNo41
1857x26 E3.I271 at1_off0.60899434.409NoNoNoNo11
1866x60 E3.I271 at1_off0.020814530.5186NoNoNoNo31
1876x60 E3.I270 at1_off0.15174922.7193NoNoNoNo32
1886x63 E3.I270 at1_off018.8104NoYesNoNo12
1892x38 4x38 at1_off010.5976NoNoNoNo77
1902x63 E1.Y92 at1_off0.014598312.0168YesYesYesYes54
1912x53 7x42 at1_off016.3484NoYesNoYes67
1926x44 7x45 at1_off043.5042YesYesNoNo99

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Midway



Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Node1Node2OwnerNet1LinkStrengthNet2LinkStrengthComm1Comm2Node1ShellNode2Shell
1x39LigShared9.9952.780210
2x60LigShared27.5416.211210
3x29Ligat1_off3.34501010
3x32LigShared15.233.931210
3x33LigShared13.425.280210
4x65Ligat1_off24.4701010
E2x52LigShared5.886.190210
7x38LigShared9.156.410210
7x42Ligat1_off3.7601210
NT.K20NT.R23at1_off6.1900021
7x31NT.A21Shared4.634.630212
1x32NT.R23at1_off5.3401021
E1.Y92NT.R23Shared6.1757.21211
1x32E1.Y92Shared6.7054.131021
1x351x39Shared7.256.040021
1x352x64Shared8.363.040022
1x357x35Shared3.395.080021
1x392x57Shared7.6158.210212
1x392x61Shared3.3352.670212
1x397x39Shared5.3754.030212
2x532x57at1_off6.701022
2x533x32at1_off6.5501021
2x533x35Shared13.291.561022
2x537x42at1_off14.4401021
2x602x63Shared4.823.861211
2x60E1x50at1_off10.3101212
2x603x28Shared3.893.891212
2x603x29at1_off4.9401211
2x60E2x50at1_off3.26501212
2x63E1.Y92Shared6.4510.921211
2x63E1x50Shared8.210.611212
2x64E1.Y92Shared5.627.490021
7x35E1.Y92Shared3.4752.780211
3x25E1x50Shared4.579.141222
E1x50E2x50Shared11.115.671222
3x25E2x50Shared7.287.281222
3x294x65Shared13.83515.811011
3x327x42Shared5.053.791211
3x334x57Shared3.266.520212
3x357x42at1_off6.97501021
3x366x48Shared13.673.420212
3x373x41Shared3.616.190212
3x374x56Shared9.348.010212
3x375x43Shared3.5854.780211
4x64E2x52at1_off14.7100021
E2.I172E2.V179Shared5.3753.070021
E2.Y184E2x52Shared12.8954.130211
6x62E2.Y184Shared9.58512.40021
6x487x42at1_off7.23500221
6x516x55Shared5.4756.850212
6x517x37Shared8.8958.210212
6x517x38Shared9.283.980211
6x586x62at1_off9.1400012
6x587x34at1_off5.54500011
6x617x30Shared4.614.610212
E2.E185E2.H183Shared4.314.920021
6x617x27at1_off3.2500212
2x63E2.V179at1_off3.15501211
E3.R272NT.D17at1_off2.9800021
6x587x30at1_off2.9200012
7x307x31at1_off2.9200021
5x405x43at1_off2.61500021
1x317x35at1_off2.54041521
E2.F170E2.H183Shared2.263.390221
5x36E2.Y184Shared2.0854.170021
4x61Ligat1_off2.0200010
3x304x61at1_off1.7900021
2x563x28at1_off1.6800022
5x395x42at1_off1.47500022
NT.D17NT.S16at1_off1.4700012
NT.P19NT.S16at1_off0.8900022
E2.V179E2x51at1_off0.8500211
NT.I14NT.K12at1_on_gp05.820222
E2.F170NT.K12at1_on_gp06.20222
E2.H183NT.K12at1_on_gp02.620212
E2.F170NT.I14at1_on_gp010.050222
E2.I172NT.I14at1_on_gp02.940022
E2.H183NT.I14at1_on_gp013.260212
NT.D16NT.P19at1_on_gp06.440212
E2.I172NT.D16at1_on_gp02.80021
LigNT.D16at1_on_gp07.241201
LigNT.D17at1_on_gp04.211201
LigNT.R23at1_on_gp03.761201
1x311x35at1_on_gp02.9441522
1x397x38at1_on_gp06.040211
2x562x60at1_on_gp04.850021
2x577x42at1_on_gp08.210021
2x604x65at1_on_gp031211
2x63Ligat1_on_gp04.841210
E1.Y92Ligat1_on_gp010.641210
3x254x65at1_on_gp02.791221
3x323x36at1_on_gp02.981211
3x334x61at1_on_gp03.420211
3x367x42at1_on_gp07.030211
3x36Ligat1_on_gp04.870210
3x375x42at1_on_gp04.990212
3x37Ligat1_on_gp04.130210
4x645x36at1_on_gp04.580022
4x65E2x52at1_on_gp017.11011
E2.V179Ligat1_on_gp04.670210
E2x51Ligat1_on_gp04.950010
5x39E2x52at1_on_gp04.870021
E2.H183Ligat1_on_gp0160210
E2.Y184Ligat1_on_gp012.090210
5x436x51at1_on_gp07.860211
5x436x55at1_on_gp010.510212
5x43Ligat1_on_gp024.770210
6x517x34at1_on_gp03.940211
6x51Ligat1_on_gp07.920210
6x58Ligat1_on_gp014.050010
6x61E3.I271at1_on_gp05.890212
6x61Ligat1_on_gp05.010210
7x31Ligat1_on_gp022.070210
7x347x37at1_on_gp03.010212
7x347x38at1_on_gp02.920211
7x34Ligat1_on_gp013.980210
7x35Ligat1_on_gp07.630210
3x304x57at1_on_gp01.710022
5x395x40at1_on_gp01.710022
NT.K20NT.P19at1_on_gp01.670022

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
Id Description
at1_on_gp 7F6G-AT1-SAR1-AngII-Gq/β1/γ2
at1_off 4YAY-AT1-ZD-7155
4ZUD-AT1-Olmesartan
Network Difference
Value at1_on_gp at1_off
Imin 2.61 3.255
Number of Linked Nodes 996 281
Number of Specific Nodes 734 (73.69%) 19  (6.76%)
Number of Shared Nodes 262 (26.31%) 262  (93.24%)
Number of Links 1305 315
Number of Specific Links 1145 (87.74%) 155  (49.21%)
Number of Shared Links 160 (12.26%) 160  (50.79%)
Number of Hubs 238 41
Number of Specific Hubs 213 (89.50%) 16  (39.02%)
Number of Shared Hubs 25 (10.50%) 25  (60.98%)
Average % Shared Neighbours (Jaccard) 10.19
Average % Shared Neighbours (Otsuka) 12.99
Average % Shared Neighbours (Overlap Coefficient) 16.00
Average % Shared Cliques (k3-6) 50.32
Graphlets Similarity 0.62716
Paths Difference
Value at1_on_gp at1_off
Number Of Nodes in MetaPath 92 96
Specific Nodes in MetaPath 82 (89.13%) 86  (89.58%)
Shared Nodes in MetaPath 262 (26.31%) 262  (26.31%)
Number Of Links MetaPath 92 103
Specific Links in MetaPath 89 (96.74%) 100  (97.09%)
Shared Links in MetaPath 160 (12.26%) 160  (12.26%)
Number of Shortest Paths 4441852 82438
Length Of Smallest Path 3 3
Average Path Length 37.9784 15.111
Length of Longest Path 63 35
Minimum Path Strength 1.21 0.71
Average Path Strength 5.92363 6.3654
Maximum Path Strength 23.5 21.385
Minimum Path Correlation 0.7 0.7
Average Path Correlation 0.993793 0.911833
Maximum Path Correlation 1 0.985
Minimum % Of Corr. Nodes 2.5 3.0303
Average % Of Corr. Nodes 36.1294 36.3259
Maximum % Of Corr. Nodes 100 100
Minimum Path Hubs % 0 0
Average Path Hubs % 61.8793 47.8199
Maximum Path Hubs % 100 100

Details about the values in these tables can be found in the corresponding documentation page .

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download at1_off_on_gp.zip<



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