psnGPCR

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Orange: nodes, hubs and links specific of bb2_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of bb2_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	bb2_off Int. Strength	bb2_on Int. Strength	bb2_off Hub1?	bb2_on Hub1?	bb2_off Hub2?	bb2_on Hub2?	ConSurf1	ConSurf2
1	E2.Y199	Lig	bb2_off	13.06	0	Yes	Yes	Yes	Yes	5	0
2	5x36	Lig	bb2_off	8.23	0	No	No	Yes	Yes	3	0
3	5x39	Lig	bb2_off	7.16	0	Yes	No	Yes	Yes	6	0
4	1x31	1x34	bb2_off	6.14	0	No	No	No	No	4	5
5	1x36	2x64	bb2_off	9.74	0	No	No	Yes	Yes	6	4
6	1x39	1x43	bb2_off	10.88	0	Yes	Yes	Yes	No	7	7
7	1x42	7x42	bb2_off	6.28	0	No	No	Yes	Yes	7	7
8	1x43	2x54	bb2_off	4.28	0	Yes	No	No	No	7	6
9	1x43	7x42	bb2_off	7.54	0	Yes	No	Yes	Yes	7	7
10	1x49	7x50	bb2_off	4.06	0	No	No	No	No	8	9
11	1x50	2x47	bb2_off	4.69	0	Yes	No	No	No	9	9
12	1x50	2x51	bb2_off	5.49	0	Yes	No	No	No	9	8
13	1x51	2x51	bb2_off	4.28	0	No	No	No	No	4	8
14	1x53	8x50	bb2_off	7.31	0	No	No	Yes	No	9	9
15	1x54	2x44	bb2_off	6.19	0	No	No	No	No	7	5
16	1x57	2x41	bb2_off	4.87	0	No	No	No	No	7	6
17	2x38	2x42	bb2_off	3.93	0	Yes	No	Yes	Yes	7	7
18	2x38	4x42	bb2_off	5.09	0	Yes	No	No	No	7	7
19	2x39	3x49	bb2_off	6.44	0	No	No	No	No	8	8
20	2x39	6x33	bb2_off	6.57	0	No	No	No	No	8	8
21	2x42	3x42	bb2_off	3.89	0	Yes	Yes	Yes	No	7	8
22	2x45	4x50	bb2_off	4.94	0	No	No	Yes	No	9	9
23	2x52	3x31	bb2_off	4.28	0	No	No	No	No	7	5
24	2x551	3x28	bb2_off	4.56	0	No	No	No	Yes	5	5
25	2x58	E1x52	bb2_off	4.33	0	No	No	No	Yes	9	7
26	2x62	E1x52	bb2_off	3.96	0	No	No	No	Yes	4	7
27	E1.D104	E2.E186	bb2_off	10.39	0	No	No	Yes	Yes	4	3
28	E1x49	E2.F193	bb2_off	4.28	0	No	No	No	Yes	4	1
29	E1x50	E2.L181	bb2_off	4.56	0	Yes	Yes	Yes	No	8	4
30	3x22	E2.L181	bb2_off	6.07	0	No	No	Yes	No	4	4
31	3x26	E2.D180	bb2_off	9.68	0	No	No	No	No	7	4
32	3x27	3x31	bb2_off	7.14	0	No	No	No	No	5	5
33	3x30	3x34	bb2_off	3.89	0	Yes	Yes	No	No	6	5
34	3x33	4x57	bb2_off	4.73	0	No	No	No	No	4	7
35	3x33	4x61	bb2_off	9.28	0	No	No	Yes	Yes	4	5
36	3x36	6x48	bb2_off	4.9	0	No	No	Yes	Yes	7	8
37	3x39	6x44	bb2_off	7.44	0	Yes	No	No	No	9	9
38	3x39	7x45	bb2_off	9.79	0	Yes	No	Yes	Yes	9	9
39	3x39	7x46	bb2_off	4.59	0	Yes	No	Yes	No	9	8
40	3x40	6x44	bb2_off	6.55	0	No	No	No	No	8	9
41	3x41	5x461	bb2_off	4.29	0	Yes	No	No	Yes	5	6
42	3x42	4x49	bb2_off	4.56	0	Yes	No	No	No	8	7
43	3x46	6x37	bb2_off	7.45	0	No	No	No	No	9	8
44	3x49	3x50	bb2_off	5.96	0	No	No	Yes	Yes	8	9
45	3x50	3x53	bb2_off	4.15	0	Yes	Yes	No	No	9	8
46	3x50	6x33	bb2_off	13.36	0	Yes	Yes	No	No	9	8
47	3x50	6x37	bb2_off	3.92	0	Yes	Yes	No	No	9	8
48	3x53	6x30	bb2_off	4.53	0	No	No	No	No	8	7
49	3x56	I2x51	bb2_off	6.2	0	No	No	No	No	6	5
50	I2x54	I2x57	bb2_off	4.95	0	No	No	No	No	5	7
51	4x60	4x64	bb2_off	4.33	0	No	No	No	No	7	5
52	4x65	E2x52	bb2_off	5.34	0	No	No	No	No	5	4
53	E2.I194	E2.L181	bb2_off	4.28	0	No	No	Yes	No	4	4
54	E2.E187	E2.H185	bb2_off	4.92	0	No	No	No	No	4	2
55	E2.F193	E2.Q191	bb2_off	15.23	0	No	Yes	No	No	1	2
56	6x58	E2.Y199	bb2_off	4.12	0	No	No	Yes	Yes	4	5
57	E2.H201	E3.S292	bb2_off	9.76	0	No	No	No	No	3	1
58	5x36	E3.Y291	bb2_off	6.95	0	No	No	Yes	Yes	3	1
59	5x40	6x60	bb2_off	3.82	0	No	No	No	No	5	5
60	5x47	5x51	bb2_off	8.21	0	Yes	No	No	No	8	6
61	5x53	5x57	bb2_off	3.63	0	No	No	No	No	7	7
62	5x58	6x38	bb2_off	14.07	0	Yes	Yes	No	No	8	5
63	5x65	6x31	bb2_off	4.23	0	No	No	No	No	8	5
64	6x26	6x30	bb2_off	12.74	0	No	No	No	No	3	7
65	6x39	7x56	bb2_off	5.96	0	No	No	No	No	6	7
66	6x40	7x53	bb2_off	8.53	0	No	No	No	No	7	9
67	6x43	7x45	bb2_off	4.12	0	No	No	Yes	Yes	7	9
68	6x47	7x45	bb2_off	4.72	0	No	No	Yes	Yes	8	9
69	6x48	6x51	bb2_off	4.52	0	Yes	Yes	Yes	No	8	5
70	6x48	7x41	bb2_off	6.48	0	Yes	Yes	No	No	8	8
71	6x51	7x37	bb2_off	4.69	0	Yes	No	No	No	5	6
72	6x61	E3.E293	bb2_off	8.62	0	No	No	No	No	2	5
73	7x30	7x33	bb2_off	4.11	0	No	Yes	No	No	4	4
74	7x53	8x50	bb2_off	13.4	0	No	No	Yes	No	9	9
75	6x40	7x49	bb2_off	3.62	0	No	No	No	Yes	7	9
76	1x32	2x64	bb2_off	3.52	0	No	No	Yes	Yes	4	4
77	1x42	7x47	bb2_off	3.27	0	No	No	No	No	7	7
78	5x68	6x27	bb2_off	3.1	0	No	No	No	No	6	4
79	1x56	1x60	bb2_off	3.07	0	No	No	Yes	No	7	6
80	5x68	6x31	bb2_off	3.06	0	No	No	No	No	6	5
81	2x38	4x39	bb2_off	2.98	0	Yes	No	No	No	7	2
82	2x59	2x60	bb2_off	2.92	0	No	Yes	No	Yes	6	6
83	6x26	6x29	bb2_off	2.89	0	No	No	No	No	3	5
84	4x52	4x55	bb2_off	2.85	0	No	No	No	No	4	4
85	5x41	5x45	bb2_off	2.83	0	No	No	No	No	4	4
86	2x49	4x50	bb2_off	2.81	0	No	No	Yes	No	8	9
87	3x24	E1x50	bb2_off	2.81	0	No	No	Yes	Yes	6	8
88	5x63	5x64	bb2_off	2.8	0	No	No	No	No	3	5
89	2x42	4x46	bb2_off	2.77	0	Yes	Yes	No	No	7	7
90	6x25	6x28	bb2_off	2.7	0	No	No	No	No	4	4
91	1x39	2x57	bb2_off	2.67	0	Yes	Yes	No	No	7	7
92	5x47	6x45	bb2_off	2.67	0	Yes	No	No	No	8	6
93	5x58	6x34	bb2_off	2.67	0	Yes	Yes	No	No	8	6
94	E3.S292	E3.Y291	bb2_off	2.54	0	No	No	Yes	Yes	1	1
95	E2.E186	E2.F184	bb2_off	2.33	0	Yes	Yes	No	Yes	3	2
96	6x42	6x45	bb2_off	1.95	0	No	No	No	No	5	6
97	E2.P200	Lig	bb2_off	1.83	0	No	No	Yes	Yes	5	0
98	1x54	1x58	bb2_off	1.64	0	No	No	No	No	7	3
99	5x32	E2.P200	bb2_off	1.63	0	No	No	No	No	2	5
100	5x55	5x56	bb2_off	1.62	0	No	No	No	No	5	4
101	3x26	4x62	bb2_off	1.61	0	No	No	No	No	7	5
102	E3.T296	E3.V294	bb2_off	1.59	0	No	No	No	No	3	5
103	7x43	7x48	bb2_off	1.59	0	No	No	No	No	5	6
104	2x66	E1x51	bb2_off	1.58	0	No	No	No	No	4	3
105	6x43	7x52	bb2_off	1.58	0	No	No	No	No	7	8
106	1x55	1x59	bb2_off	1.5	0	No	No	No	No	4	5
107	5x32	E2.S202	bb2_off	1.49	0	No	No	No	No	2	3
108	3x52	4x45	bb2_off	1.44	0	No	No	No	No	4	6
109	I2x54	I2x56	bb2_off	1.44	0	No	No	No	No	5	5
110	1x31	1x32	bb2_off	1.43	0	No	No	No	No	4	4
111	6x35	7x56	bb2_off	1.41	0	No	No	No	No	6	7
112	I2x53	I2x54	bb2_off	1.37	0	No	No	No	No	6	5
113	6x32	8x49	bb2_off	1.32	0	No	No	No	No	8	6
114	7x39	7x42	bb2_off	1.22	0	No	No	Yes	Yes	5	7
115	2x64	2x65	bb2_off	1.17	0	Yes	Yes	No	No	4	4
116	3x29	Lig	Shared	10.97	15.255	No	Yes	Yes	Yes	5	0
117	3x32	Lig	Shared	10.38	4.54	No	Yes	Yes	Yes	6	0
118	4x61	Lig	Shared	16.23	4.925	Yes	Yes	Yes	Yes	5	0
119	E2x52	Lig	Shared	15.54	17.945	No	No	Yes	Yes	4	0
120	6x48	Lig	Shared	8.24	4.03	Yes	Yes	Yes	Yes	8	0
121	6x51	Lig	Shared	4.59	8.165	Yes	No	Yes	Yes	5	0
122	6x52	Lig	Shared	6.44	5.09	No	Yes	Yes	Yes	7	0
123	6x55	Lig	Shared	26.11	5.65	Yes	Yes	Yes	Yes	5	0
124	7x38	Lig	Shared	10.15	11.69	No	Yes	Yes	Yes	5	0
125	1x35	2x64	Shared	9.67	3.025	No	No	Yes	Yes	6	4
126	1x39	2x60	Shared	12.64	5.175	Yes	Yes	No	Yes	7	6
127	1x39	7x42	Shared	14.44	4.13	Yes	Yes	Yes	Yes	7	7
128	1x44	1x48	Shared	7.14	5.71	No	No	No	No	5	5
129	1x45	7x51	Shared	5.02	2.51	No	No	No	No	6	5
130	1x50	2x50	Shared	5.39	6.73	Yes	No	Yes	Yes	9	9
131	1x50	7x50	Shared	11.4	4.89	Yes	No	No	No	9	9
132	1x52	8x54	Shared	11.67	14.27	No	No	Yes	Yes	7	7
133	1x53	2x43	Shared	4.28	4.28	No	No	No	No	9	8
134	1x55	8x57	Shared	13.56	7.46	No	No	No	No	4	5
135	1x56	8x57	Shared	4.12	8.235	No	No	No	No	7	5
136	1x57	I1x51	Shared	4.28	14.97	No	No	No	No	7	7
137	1x57	2x44	Shared	5.28	9.25	No	No	No	No	7	5
138	1x60	I1x50	Shared	6.09	8.37	Yes	No	No	No	6	7
139	2x40	I1x50	Shared	4.21	4.21	No	No	No	No	8	7
140	2x37	2x39	Shared	8.15	11.4	No	No	No	No	8	8
141	2x37	2x40	Shared	13.62	8.17	No	No	No	No	8	8
142	2x38	3x49	Shared	8.76	4.38	Yes	No	No	No	7	8
143	2x42	3x45	Shared	6.93	4.16	Yes	Yes	No	No	7	7
144	2x42	3x46	Shared	7.31	2.44	Yes	Yes	No	No	7	9
145	2x42	4x45	Shared	6.2	5.58	Yes	Yes	No	No	7	6
146	2x45	3x42	Shared	4.8	6.4	No	No	Yes	No	9	8
147	2x46	3x42	Shared	7.37	2.95	No	Yes	Yes	No	9	8
148	2x46	3x43	Shared	4.15	6.92	No	Yes	No	No	9	9
149	2x48	4x50	Shared	6.83	3.42	No	No	Yes	No	7	9
150	2x50	3x39	Shared	11.06	5.89	Yes	Yes	Yes	No	9	9
151	2x50	7x46	Shared	10.31	10.31	Yes	Yes	Yes	No	9	8
152	2x50	7x49	Shared	5.39	6.73	Yes	Yes	No	Yes	9	9
153	2x53	3x35	Shared	6.01	3	No	Yes	No	No	7	8
154	2x53	7x46	Shared	4.5	4.5	No	Yes	Yes	No	7	8
155	2x54	7x46	Shared	4.5	7.51	No	No	Yes	No	6	8
156	2x551	3x31	Shared	4.56	4.56	No	No	No	No	5	5
157	2x56	3x32	Shared	4.58	10.68	No	Yes	No	Yes	7	6
158	2x57	2x58	Shared	3.74	1.87	No	No	No	No	7	9
159	2x63	E1x50	Shared	6	5	No	No	Yes	Yes	5	8
160	E1x49	E1x51	Shared	7.29	5.465	No	No	No	No	4	3
161	E1x50	E1x52	Shared	15.03	15.03	Yes	Yes	No	Yes	8	7
162	3x25	E1x50	Shared	3.92	5.22	No	No	Yes	Yes	9	8
163	E1x50	E2x50	Shared	6.53	17.63	Yes	Yes	No	No	8	9
164	3x22	E2.D180	Shared	13.1	13.1	No	No	No	No	4	4
165	3x25	E2.L181	Shared	4.76	3.17	No	No	Yes	No	9	4
166	3x25	E2x50	Shared	7.28	7.28	No	No	No	No	9	9
167	3x28	3x32	Shared	4.12	4.12	No	Yes	No	Yes	5	6
168	3x29	4x61	Shared	6.29	3.145	No	Yes	Yes	Yes	5	5
169	3x29	4x65	Shared	5.34	6.235	No	Yes	No	No	5	5
170	3x30	4x54	Shared	6.22	3.73	Yes	Yes	No	No	6	4
171	3x30	4x57	Shared	4.16	5.545	Yes	Yes	No	No	6	7
172	3x30	4x59	Shared	3.77	4.395	Yes	Yes	No	No	6	4
173	3x34	4x54	Shared	7.53	9.035	No	No	No	No	5	4
174	3x37	3x41	Shared	6.02	3.01	No	Yes	Yes	No	6	5
175	3x37	4x53	Shared	3.71	3.71	No	Yes	No	No	6	8
176	3x38	4x50	Shared	15.94	19.615	No	No	Yes	No	7	9
177	3x40	3x41	Shared	3.93	7.87	No	No	Yes	No	8	5
178	3x40	5x50	Shared	5.3	5.3	No	No	No	No	8	9
179	3x41	4x49	Shared	6.28	3.77	Yes	No	No	No	5	7
180	3x44	5x54	Shared	6.08	3.8	No	No	No	No	7	8
181	3x47	5x54	Shared	10.84	7.74	No	No	No	No	9	8
182	3x47	5x58	Shared	5.09	12.085	No	No	Yes	Yes	9	8
183	3x48	5x57	Shared	5.34	5.34	No	No	No	No	7	7
184	3x51	3x55	Shared	17.66	12.62	Yes	Yes	No	No	8	7
185	3x51	5x57	Shared	8.94	12.41	Yes	Yes	No	No	8	7
186	3x51	5x60	Shared	4.13	4.13	Yes	Yes	No	Yes	8	3
187	3x51	5x61	Shared	3.63	3.63	Yes	Yes	No	Yes	8	8
188	3x55	5x64	Shared	8.87	8.87	No	No	No	No	7	5
189	4x48	4x52	Shared	3.77	7.535	No	No	No	No	3	4
190	4x56	5x461	Shared	3.65	4.26	No	No	No	Yes	6	6
191	4x61	5x39	Shared	3.69	7.39	Yes	Yes	Yes	No	5	6
192	E2.H182	E2x51	Shared	4.39	5.12	No	Yes	No	No	1	1
193	E2.H185	E2.N190	Shared	8.93	1.915	No	No	No	No	2	3
194	E2.E186	E2.S188	Shared	10.06	4.31	Yes	Yes	No	No	3	3
195	E2.E186	E2.T189	Shared	8.47	11.995	Yes	Yes	No	No	3	1
196	E2.Q191	E2.T189	Shared	5.67	3.545	No	No	No	No	2	1
197	E2.Y199	E2x52	Shared	5.56	13.91	Yes	Yes	No	No	5	4
198	E2.Y199	E3.Y291	Shared	11.91	15.885	Yes	Yes	Yes	Yes	5	1
199	5x33	E3.Y291	Shared	16.83	0.56	No	No	Yes	Yes	1	1
200	5x34	5x38	Shared	5.71	4.28	No	No	No	No	1	4
201	5x37	6x60	Shared	16.72	13.14	No	No	No	No	3	5
202	5x39	5x43	Shared	4.18	6.97	Yes	No	No	No	6	6
203	5x39	6x55	Shared	6.53	4.9	Yes	No	Yes	Yes	6	5
204	5x40	6x56	Shared	9.01	3	No	No	No	No	5	5
205	5x40	6x59	Shared	6.52	6.52	No	No	No	No	5	4
206	5x43	6x55	Shared	7.63	3.18	No	No	Yes	Yes	6	5
207	5x44	5x47	Shared	8.25	8.25	No	Yes	Yes	No	6	8
208	5x44	5x48	Shared	6.55	3.275	No	Yes	No	No	6	5
209	5x44	6x52	Shared	6.79	9.615	No	Yes	No	Yes	6	7
210	5x45	5x48	Shared	4.47	3.725	No	No	No	No	4	5
211	5x46	5x461	Shared	5.24	4.59	No	No	No	Yes	5	6
212	5x47	6x49	Shared	9.38	5.86	Yes	No	No	No	8	6
213	5x47	6x52	Shared	7.62	5.44	Yes	No	No	Yes	8	7
214	5x54	6x41	Shared	6.14	3.84	No	No	No	No	8	7
215	5x58	5x61	Shared	12.09	3.63	Yes	Yes	No	Yes	8	8
216	5x58	6x37	Shared	5.05	8.2	Yes	Yes	No	No	8	8
217	5x59	5x60	Shared	9.28	5.16	No	No	No	Yes	3	3
218	6x36	6x40	Shared	3.89	2.59	No	No	No	No	8	7
219	6x36	7x56	Shared	10.32	10.32	No	No	No	No	8	7
220	6x44	6x48	Shared	14.03	13.03	No	No	Yes	Yes	9	8
221	6x46	7x40	Shared	6.09	6.7	No	No	No	No	6	8
222	6x47	7x40	Shared	4.76	3.965	No	No	No	No	8	8
223	6x51	7x41	Shared	4.69	5.47	Yes	No	No	No	5	8
224	6x54	7x33	Shared	4.56	3.04	No	No	No	No	5	4
225	6x55	6x59	Shared	5.09	6.995	Yes	Yes	No	No	5	4
226	6x57	6x61	Shared	28.31	6.53	No	No	No	No	4	2
227	7x27	E3.D295	Shared	7.36	5.89	No	No	No	No	3	1
228	7x30	E3.D295	Shared	8.82	3.15	No	Yes	No	No	4	1
229	7x30	7x34	Shared	6.97	6.97	No	Yes	No	No	4	4
230	7x31	7x35	Shared	10.05	7.54	No	Yes	No	No	4	4
231	7x45	7x49	Shared	8.17	10.9	Yes	Yes	No	Yes	9	9
232	7x54	8x51	Shared	11.32	11.835	Yes	Yes	No	No	7	8
233	7x54	8x54	Shared	9.28	8.765	Yes	Yes	Yes	Yes	7	7
234	7x54	8x55	Shared	5.81	5.81	Yes	Yes	No	No	7	4
235	8x47	8x49	Shared	4.89	4.89	No	No	No	No	8	6
236	8x48	8x51	Shared	4.95	1.855	No	No	No	No	4	8
237	8x50	8x54	Shared	8.57	4.29	Yes	No	Yes	Yes	9	7
238	8x54	8x58	Shared	6.09	4.87	Yes	Yes	No	No	7	7
239	1x48	1x49	Shared	3.53	3.53	No	No	No	No	5	8
240	4x59	4x60	Shared	3.39	3.39	No	No	No	No	4	7
241	5x49	5x50	Shared	3.39	3.39	No	No	No	No	5	9
242	6x49	6x50	Shared	3.28	2.46	No	No	No	No	6	9
243	1x54	2x47	Shared	3.25	2.435	No	No	No	No	7	9
244	1x60	I1x49	Shared	3.23	3.23	Yes	No	No	No	6	6
245	1x60	8x53	Shared	2.87	2.87	Yes	No	No	No	6	6
246	E3.E293	E3.S292	Shared	2.87	5.75	No	No	No	No	5	1
247	1x43	1x47	Shared	2.85	2.85	Yes	No	No	No	7	6
248	3x54	5x65	Shared	2.85	2.85	No	No	No	No	8	8
249	4x51	4x55	Shared	2.85	0.715	No	No	No	No	5	4
250	4x52	4x56	Shared	2.85	2.14	No	No	No	No	4	6
251	5x61	5x65	Shared	2.85	2.85	No	Yes	No	No	8	8
252	5x41	6x56	Shared	2.83	3.535	No	No	No	No	4	5
253	3x21	E1x50	Shared	2.81	2.81	No	No	Yes	Yes	8	8
254	E2.F184	E2.S195	Shared	2.64	4.62	No	Yes	No	No	2	4
255	8x47	8x50	Shared	2.64	2.64	No	No	Yes	No	8	9
256	4x40	I2x57	Shared	2.63	3.94	No	No	No	No	3	7
257	5x56	5x60	Shared	2.62	3.275	No	No	No	Yes	4	3
258	E2.D180	E2.H182	Shared	2.52	5.04	No	No	No	Yes	4	1
259	6x54	6x58	Shared	2.51	6.26	No	No	No	No	5	4
260	7x54	7x55	Shared	2.34	1.76	Yes	Yes	No	No	7	6
261	4x64	5x35	Shared	2.26	12.445	No	No	No	Yes	5	1
262	1x46	7x47	Shared	1.96	1.96	No	No	No	No	8	7
263	1x40	1x43	Shared	1.76	3.53	No	No	Yes	No	4	7
264	1x45	1x46	Shared	1.76	1.76	No	No	No	No	6	8
265	3x23	3x24	Shared	1.76	0.88	No	No	No	No	2	6
266	7x47	7x48	Shared	1.71	1.71	No	No	No	No	7	6
267	2x38	4x38	Shared	1.7	1.7	Yes	No	No	No	7	7
268	5x48	5x52	Shared	1.62	1.62	No	No	No	No	5	3
269	2x41	4x43	Shared	1.59	3.17	No	No	No	No	6	1
270	1x38	1x42	Shared	1.54	2.305	No	No	No	No	6	7
271	E2.H182	E2.P183	Shared	1.53	1.53	No	Yes	No	No	1	2
272	6x49	6x53	Shared	1.49	2.98	No	No	No	No	6	7
273	7x29	7x33	Shared	1.47	2.95	No	No	No	No	2	4
274	1x47	2x55	Shared	1.43	4.28	No	No	No	No	6	5
275	I2x51	I2x52	Shared	1.39	8.32	No	No	No	No	5	5
276	E2.H185	E2.T192	Shared	1.37	2.74	No	No	No	No	2	4
277	1x33	1x37	bb2_on	0	4.005	No	No	No	No	3	6
278	1x35	1x36	bb2_on	0	3.39	No	No	No	No	6	6
279	1x35	1x39	bb2_on	0	6.045	No	No	Yes	Yes	6	7
280	1x39	7x38	bb2_on	0	3.09	Yes	Yes	No	Yes	7	5
281	1x39	7x39	bb2_on	0	11.72	Yes	Yes	No	No	7	5
282	1x43	2x57	bb2_on	0	3.25	Yes	No	No	No	7	7
283	1x49	7x51	bb2_on	0	4.52	No	No	No	No	8	5
284	1x52	8x58	bb2_on	0	7.37	No	No	No	No	7	7
285	1x53	2x47	bb2_on	0	4.73	No	No	No	No	9	9
286	1x53	7x50	bb2_on	0	3.28	No	No	No	No	9	9
287	1x56	8x50	bb2_on	0	3.77	No	No	Yes	No	7	9
288	1x59	8x57	bb2_on	0	13.465	No	No	No	No	5	5
289	2x38	2x39	bb2_on	0	3.53	Yes	No	No	No	7	8
290	2x42	3x49	bb2_on	0	5.975	Yes	Yes	No	No	7	8
291	2x43	3x46	bb2_on	0	3.565	No	No	No	No	8	9
292	2x46	2x50	bb2_on	0	7.465	No	Yes	Yes	Yes	9	9
293	2x46	3x39	bb2_on	0	3	No	Yes	Yes	No	9	9
294	2x46	7x49	bb2_on	0	6.87	No	Yes	No	Yes	9	9
295	2x52	3x35	bb2_on	0	6.01	No	No	No	No	7	8
296	2x53	2x56	bb2_on	0	4.76	No	Yes	No	Yes	7	7
297	2x56	7x42	bb2_on	0	4.89	No	Yes	Yes	Yes	7	7
298	2x56	Lig	bb2_on	0	5.545	No	Yes	Yes	Yes	7	0
299	2x57	7x42	bb2_on	0	4.16	No	No	Yes	Yes	7	7
300	2x59	E1x52	bb2_on	0	6.555	No	Yes	No	Yes	6	7
301	2x59	3x28	bb2_on	0	4.61	No	Yes	No	Yes	6	5
302	2x59	3x32	bb2_on	0	4.3	No	Yes	No	Yes	6	6
303	2x60	2x63	bb2_on	0	4.17	No	Yes	No	No	6	5
304	2x60	2x64	bb2_on	0	9.195	No	Yes	Yes	Yes	6	4
305	2x60	7x38	bb2_on	0	4.76	No	Yes	No	Yes	6	5
306	2x60	Lig	bb2_on	0	4.69	No	Yes	Yes	Yes	6	0
307	2x63	Lig	bb2_on	0	15.295	No	No	Yes	Yes	5	0
308	2x64	7x31	bb2_on	0	5.675	Yes	Yes	No	Yes	4	4
309	2x64	7x34	bb2_on	0	3.18	Yes	Yes	No	No	4	4
310	2x64	7x35	bb2_on	0	4.23	Yes	Yes	No	No	4	4
311	2x64	Lig	bb2_on	0	14.95	Yes	Yes	Yes	Yes	4	0
312	E1.D104	E1x49	bb2_on	0	3.57	No	No	No	No	4	4
313	E1.D104	E2.F193	bb2_on	0	4.18	No	No	No	Yes	4	1
314	E1.D104	Lig	bb2_on	0	4.705	No	No	Yes	Yes	4	0
315	E1x50	Lig	bb2_on	0	5.965	Yes	Yes	Yes	Yes	8	0
316	3x28	E1x52	bb2_on	0	6.28	No	Yes	No	Yes	5	7
317	3x22	3x26	bb2_on	0	3.715	No	No	No	No	4	7
318	3x28	3x29	bb2_on	0	3.39	No	Yes	No	Yes	5	5
319	3x30	4x62	bb2_on	0	3.465	Yes	Yes	No	No	6	5
320	3x33	5x461	bb2_on	0	8.53	No	No	No	Yes	4	6
321	3x33	Lig	bb2_on	0	5.04	No	No	Yes	Yes	4	0
322	3x34	4x57	bb2_on	0	3.36	No	No	No	No	5	7
323	3x36	3x37	bb2_on	0	3.68	No	No	No	Yes	7	6
324	3x36	5x461	bb2_on	0	4.585	No	No	No	Yes	7	6
325	3x36	Lig	bb2_on	0	5.51	No	No	Yes	Yes	7	0
326	3x37	5x461	bb2_on	0	3.765	No	Yes	No	Yes	6	6
327	3x38	4x53	bb2_on	0	4.85	No	No	No	No	7	8
328	3x43	7x49	bb2_on	0	9.61	No	No	No	Yes	9	9
329	3x44	5x53	bb2_on	0	4.56	No	No	No	No	7	7
330	3x46	3x50	bb2_on	0	3.64	No	No	Yes	Yes	9	9
331	3x50	5x58	bb2_on	0	8.23	Yes	Yes	Yes	Yes	9	8
332	3x50	7x53	bb2_on	0	3.64	Yes	Yes	No	No	9	9
333	I2x56	I2x57	bb2_on	0	3.485	No	No	No	No	5	7
334	4x61	4x65	bb2_on	0	4.31	Yes	Yes	No	No	5	5
335	4x61	E2x52	bb2_on	0	7.075	Yes	Yes	No	No	5	4
336	4x63	4x64	bb2_on	0	3.93	No	No	No	No	4	5
337	4x65	Lig	bb2_on	0	4.88	No	No	Yes	Yes	5	0
338	E2.H182	E2.P200	bb2_on	0	6.1	No	Yes	No	No	1	5
339	E2.H182	E3.Y291	bb2_on	0	3.27	No	Yes	Yes	Yes	1	1
340	E2.F184	E2.H201	bb2_on	0	9.615	No	Yes	No	No	2	3
341	E2.F184	E3.Y291	bb2_on	0	7.735	No	Yes	Yes	Yes	2	1
342	E2.F184	E3.V294	bb2_on	0	3.93	No	Yes	No	No	2	5
343	E2.F184	Lig	bb2_on	0	15.73	No	Yes	Yes	Yes	2	0
344	E2.E186	E3.T296	bb2_on	0	5.645	Yes	Yes	No	No	3	3
345	E2.E186	Lig	bb2_on	0	11.885	Yes	Yes	Yes	Yes	3	0
346	E2.F193	Lig	bb2_on	0	10.375	No	Yes	Yes	Yes	1	0
347	E2.S195	Lig	bb2_on	0	12.725	No	No	Yes	Yes	4	0
348	E2x50	Lig	bb2_on	0	4.45	No	No	Yes	Yes	9	0
349	5x35	E2.Y199	bb2_on	0	7.62	No	Yes	Yes	Yes	1	5
350	5x36	E2.Y199	bb2_on	0	12.52	No	No	Yes	Yes	3	5
351	6x59	E2.Y199	bb2_on	0	5.725	No	No	Yes	Yes	4	5
352	E2.P200	E2.S202	bb2_on	0	3.56	No	No	No	No	5	3
353	E2.H201	E3.Y291	bb2_on	0	22.325	No	No	Yes	Yes	3	1
354	5x32	5x35	bb2_on	0	6.38	No	No	No	Yes	2	1
355	5x35	5x36	bb2_on	0	4.58	No	Yes	No	No	1	3
356	5x40	6x55	bb2_on	0	5.09	No	No	Yes	Yes	5	5
357	5x41	6x60	bb2_on	0	3.59	No	No	No	No	4	5
358	5x44	5x45	bb2_on	0	3.045	No	Yes	No	No	6	4
359	5x51	5x55	bb2_on	0	3.75	No	No	No	No	6	5
360	5x51	6x44	bb2_on	0	6.7	No	No	No	No	6	9
361	5x51	6x45	bb2_on	0	3.15	No	No	No	No	6	6
362	5x55	6x41	bb2_on	0	3.23	No	No	No	No	5	7
363	5x58	6x41	bb2_on	0	3.79	Yes	Yes	No	No	8	7
364	5x61	6x37	bb2_on	0	3.07	No	Yes	No	No	8	8
365	5x62	6x38	bb2_on	0	4.73	No	No	No	No	6	5
366	5x65	6x33	bb2_on	0	4.15	No	No	No	No	8	8
367	5x66	5x70	bb2_on	0	3.63	No	No	No	Yes	4	0
368	5x66	6x34	bb2_on	0	3.25	No	No	No	No	4	6
369	5x68	6x30	bb2_on	0	3.95	No	No	No	No	6	7
370	5x70	6x31	bb2_on	0	7.765	No	Yes	No	No	0	5
371	5x72	I3.P245	bb2_on	0	4.93	No	No	No	No	0	0
372	5x72	6x23	bb2_on	0	4.47	No	No	No	Yes	0	0
373	5x72	6x30	bb2_on	0	4.855	No	No	No	No	0	7
374	6x23	I3.V246	bb2_on	0	4.81	No	Yes	No	No	0	0
375	6x22	I3.G248	bb2_on	0	3.18	No	No	No	No	0	0
376	6x21	6x22	bb2_on	0	10.61	No	No	No	No	0	0
377	6x23	6x27	bb2_on	0	3.07	No	Yes	No	No	0	4
378	6x25	6x26	bb2_on	0	5.42	No	No	No	No	4	3
379	6x27	6x31	bb2_on	0	4.36	No	No	No	No	4	5
380	6x32	7x56	bb2_on	0	4.86	No	No	No	No	8	7
381	6x39	6x43	bb2_on	0	2.98	No	No	No	No	6	7
382	6x40	7x52	bb2_on	0	4.16	No	No	No	No	7	8
383	6x43	7x48	bb2_on	0	4.47	No	No	No	No	7	6
384	6x44	7x45	bb2_on	0	6.04	No	No	Yes	Yes	9	9
385	6x48	6x52	bb2_on	0	4.23	Yes	Yes	No	Yes	8	7
386	6x48	7x45	bb2_on	0	9.04	Yes	Yes	Yes	Yes	8	9
387	6x50	7x37	bb2_on	0	3.74	No	No	No	No	9	6
388	6x50	7x40	bb2_on	0	4.93	No	No	No	No	9	8
389	6x51	7x38	bb2_on	0	9.04	Yes	No	No	Yes	5	5
390	6x54	7x38	bb2_on	0	5.635	No	No	No	Yes	5	5
391	6x56	6x60	bb2_on	0	3.52	No	No	No	No	5	5
392	6x57	E3.D295	bb2_on	0	5.175	No	No	No	No	4	1
393	6x57	7x30	bb2_on	0	3.27	No	No	No	Yes	4	4
394	6x58	7x30	bb2_on	0	7.9	No	No	No	Yes	4	4
395	6x58	7x38	bb2_on	0	6.93	No	No	No	Yes	4	5
396	E3.V294	Lig	bb2_on	0	8.51	No	No	Yes	Yes	5	0
397	E3.T296	Lig	bb2_on	0	5.62	No	No	Yes	Yes	3	0
398	7x30	Lig	bb2_on	0	3.705	No	Yes	Yes	Yes	4	0
399	7x31	Lig	bb2_on	0	15.535	No	Yes	Yes	Yes	4	0
400	7x42	Lig	bb2_on	0	3.09	Yes	Yes	Yes	Yes	7	0
401	7x49	7x50	bb2_on	0	3.26	No	Yes	No	No	9	9
402	Lig	Lig	bb2_on	0	37.61	Yes	Yes	Yes	Yes	0	0
403	1x29	1x33	bb2_on	0	5.565	No	No	No	No	0	3
404	1x36	2x65	bb2_on	0	4.105	No	No	No	No	6	4
405	2x53	Lig	bb2_on	0	3.535	No	Yes	Yes	Yes	7	0
406	E2.F184	E2.F193	bb2_on	0	3.215	No	Yes	No	Yes	2	1
407	E2.E186	E2.F193	bb2_on	0	4.665	Yes	Yes	No	Yes	3	1
408	E2.E187	E3.E293	bb2_on	0	6.975	No	No	No	No	4	5
409	E2.Q191	Lig	bb2_on	0	4.09	No	No	Yes	Yes	2	0
410	5x70	5x71	bb2_on	0	4.07	No	Yes	No	No	0	0
411	7x45	7x48	bb2_on	0	2.96	Yes	Yes	No	No	9	6
412	3x54	5x61	bb2_on	0	2.94	No	No	No	Yes	8	8
413	6x23	6x26	bb2_on	0	2.87	No	Yes	No	No	0	3
414	5x67	5x70	bb2_on	0	2.82	No	No	No	Yes	4	0
415	2x42	4x42	bb2_on	0	2.77	Yes	Yes	No	No	7	7
416	5x69	6x30	bb2_on	0	2.77	No	No	No	No	3	7
417	5x64	5x67	bb2_on	0	2.64	No	No	No	No	5	4
418	2x45	4x46	bb2_on	0	2.565	No	No	No	No	9	7
419	3x34	4x50	bb2_on	0	2.43	No	No	Yes	No	5	9
420	6x32	7x55	bb2_on	0	2.43	No	No	No	No	8	6
421	1x57	2x40	bb2_on	0	2.42	No	No	No	No	7	8
422	4x39	4x43	bb2_on	0	2.38	No	No	No	No	2	1
423	2x41	4x42	bb2_on	0	2.365	No	No	No	No	6	7
424	1x38	7x39	bb2_on	0	2.235	No	No	No	No	6	5
425	1x30	1x33	bb2_on	0	2.175	No	No	No	No	3	3
426	2x51	2x55	bb2_on	0	2.14	No	No	No	No	8	5
427	3x50	6x40	bb2_on	0	2.14	Yes	Yes	No	No	9	7
428	4x40	4x44	bb2_on	0	2.12	No	No	No	No	3	3
429	1x32	2x65	bb2_on	0	2.075	No	No	No	No	4	4
430	2x49	3x38	bb2_on	0	1.84	No	No	No	No	8	7
431	I3.G248	I3.V246	bb2_on	0	1.84	No	No	No	No	0	0
432	5x62	6x34	bb2_on	0	1.79	No	No	No	No	6	6
433	1x46	2x54	bb2_on	0	1.71	No	No	No	No	8	6
434	3x24	3x27	bb2_on	0	1.71	No	No	No	No	6	5
435	7x32	7x36	bb2_on	0	1.71	No	No	No	No	1	4
436	1x58	1x59	bb2_on	0	1.69	No	No	No	No	3	5
437	2x551	2x56	bb2_on	0	1.69	No	No	No	Yes	5	7
438	E2.I194	E2.P183	bb2_on	0	1.69	No	No	No	No	4	2
439	7x43	7x47	bb2_on	0	1.69	No	No	No	No	5	7
440	I3.E247	I3.G248	bb2_on	0	1.64	No	No	No	No	0	0
441	2x59	2x62	bb2_on	0	1.62	No	Yes	No	No	6	4
442	4x41	I2x55	bb2_on	0	1.61	No	No	No	No	4	5
443	1x34	1x38	bb2_on	0	1.6	No	No	No	No	5	6
444	1x41	1x45	bb2_on	0	1.54	No	No	No	No	4	6
445	7x28	7x32	bb2_on	0	1.52	No	No	No	No	3	1
446	3x24	E1x52	bb2_on	0	1.51	No	No	No	Yes	6	7
447	1x51	1x55	bb2_on	0	1.455	No	No	No	No	4	4
448	3x56	I2x50	bb2_on	0	1.44	No	No	No	No	6	8
449	4x55	4x59	bb2_on	0	1.43	No	No	No	No	4	4
450	5x32	5x34	bb2_on	0	1.37	No	No	No	No	2	1
451	3x55	3x56	bb2_on	0	1.31	No	No	No	No	7	6
452	1x31	7x31	bb2_on	0	1.26	No	No	No	Yes	4	4
453	3x52	3x56	bb2_on	0	1.24	No	No	No	No	4	6
454	7x28	7x31	bb2_on	0	1.24	No	No	No	Yes	3	4
455	8x52	8x56	bb2_on	0	0.75	No	No	No	No	4	4
456	E2.E186	E2.E187	bb2_on	0	0.635	Yes	Yes	No	No	3	4
457	5x60	5x63	bb2_on	0	0.62	No	Yes	No	No	3	3

Orange: nodes, hubs and links specific of bb2_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of bb2_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	bb2_off Avg Int. Strength	bb2_on Avg Int. Strength	bb2_off Num Of Links	bb2_on Num Of Links	ConSurf
1	1x43	bb2_off	5.462	3.21	5	3	7
2	1x50	bb2_off	6.7425	5.81	4	2	9
3	1x60	bb2_off	3.815	4.82333	4	3	6
4	2x38	bb2_off	4.492	3.20333	5	3	7
5	3x39	bb2_off	8.22	4.445	4	2	9
6	3x41	bb2_off	5.13	4.88333	4	3	5
7	3x42	bb2_off	5.155	4.675	4	2	8
8	4x50	bb2_off	7.63	8.48833	4	3	9
9	E2.L181	bb2_off	4.9175	3.17	4	1	4
10	5x39	bb2_off	5.39	6.42	4	3	6
11	5x47	bb2_off	7.226	6.51667	5	3	8
12	6x51	bb2_off	4.6225	7.55833	4	3	5
13	7x46	bb2_off	5.975	7.44	4	3	8
14	8x50	bb2_off	7.98	3.56667	4	3	9
15	Lig	Shared	10.6869	9.94812	13	32	0
16	1x39	Shared	10.1575	6.032	4	5	7
17	2x42	Shared	5.17167	4.185	6	5	7
18	2x50	Shared	8.0375	7.425	4	5	9
19	2x64	Shared	6.025	6.70917	4	6	4
20	E1x50	Shared	5.95143	8.60917	7	6	8
21	3x30	Shared	4.51	4.28375	4	4	6
22	3x50	Shared	6.8475	4.4125	4	4	9
23	3x51	Shared	8.59	8.1975	4	4	8
24	4x61	Shared	8.8725	5.369	4	5	5
25	E2.E186	Shared	7.8125	6.5225	4	6	3
26	E2.Y199	Shared	8.6625	11.132	4	5	5
27	5x58	Shared	7.794	7.187	5	5	8
28	6x48	Shared	7.634	7.5825	5	4	8
29	6x55	Shared	11.34	5.163	4	5	5
30	E3.Y291	Shared	9.5575	9.955	4	5	1
31	7x42	Shared	7.37	4.0675	4	4	7
32	7x45	Shared	6.7	7.235	4	4	9
33	7x54	Shared	7.1875	7.0425	4	4	7
34	8x54	Shared	8.9025	8.04875	4	4	7
35	2x46	bb2_on	5.76	5.441	2	5	9
36	2x53	bb2_on	5.255	3.94875	2	4	7
37	2x56	bb2_on	4.58	5.513	1	5	7
38	2x59	bb2_on	2.92	4.27125	1	4	6
39	2x60	bb2_on	7.78	5.598	2	5	6
40	E1x52	bb2_on	7.77333	7.34375	3	4	7
41	3x28	bb2_on	4.34	4.6	2	4	5
42	3x29	bb2_on	7.53333	7.00625	3	4	5
43	3x32	bb2_on	6.36	5.91	3	4	6
44	3x37	bb2_on	4.865	3.54125	2	4	6
45	E2.H182	bb2_on	2.81333	4.212	3	5	1
46	E2.F184	bb2_on	2.485	7.47417	2	6	2
47	E2.F193	bb2_on	9.755	5.60875	2	4	1
48	5x35	bb2_on	2.26	7.75625	1	4	1
49	5x44	bb2_on	7.19667	6.04625	3	4	6
50	5x461	bb2_on	4.39333	5.146	3	5	6
51	5x60	bb2_on	5.34333	3.29625	3	4	3
52	5x61	bb2_on	6.19	3.224	3	5	8
53	5x70	bb2_on	0	4.57125	0	4	0
54	6x23	bb2_on	0	3.805	0	4	0
55	6x52	bb2_on	6.95	6.09375	3	4	7
56	7x30	bb2_on	6.63333	4.999	3	5	4
57	7x31	bb2_on	10.05	6.25	1	5	4
58	7x38	bb2_on	10.15	6.8575	1	6	5
59	7x49	bb2_on	5.72667	7.474	3	5	9

Orange: nodes, hubs and links specific of bb2_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of bb2_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	bb2_off Recurrence	bb2_on Recurrence	bb2_off Hub1?	bb2_on Hub1?	bb2_off Hub2?	bb2_on Hub2?	ConSurf1	ConSurf2
1	3x32	Lig	bb2_off	10.8041	5.95836	No	Yes	Yes	Yes	6	0
2	E2.Y199	Lig	bb2_off	22.4425	0	Yes	Yes	Yes	Yes	5	0
3	5x36	Lig	bb2_off	11.1828	0	No	No	Yes	Yes	3	0
4	1x39	1x43	bb2_off	28.5368	0	Yes	Yes	Yes	No	7	7
5	1x43	2x54	bb2_off	45.305	0	Yes	No	No	No	7	6
6	3x39	7x46	bb2_off	40.3408	0	Yes	No	Yes	No	9	8
7	3x39	6x44	bb2_off	100	0	Yes	No	No	No	9	9
8	1x43	7x42	bb2_off	12.5969	0	Yes	No	Yes	Yes	7	7
9	1x42	7x42	bb2_off	11.2597	0	No	No	Yes	Yes	7	7
10	1x50	2x50	bb2_off	21.0283	6.52714	Yes	No	Yes	Yes	9	9
11	2x50	3x39	bb2_off	35.8026	2.52913	Yes	Yes	Yes	No	9	9
12	1x50	2x47	bb2_off	11.5437	0	Yes	No	No	No	9	9
13	7x53	8x50	bb2_off	32.3649	0	No	No	Yes	No	9	9
14	6x40	7x53	bb2_off	34.6015	0	No	No	No	No	7	9
15	6x40	7x49	bb2_off	45.4233	0	No	No	No	Yes	7	9
16	2x50	7x49	bb2_off	27.5132	6.89712	Yes	Yes	No	Yes	9	9
17	3x39	7x45	bb2_off	27.525	0	Yes	No	Yes	Yes	9	9
18	1x54	2x47	bb2_off	10.1414	1.8223	No	No	No	No	7	9
19	1x60	I1x50	bb2_off	11.7981	5.26258	Yes	No	No	No	6	7
20	2x40	I1x50	bb2_off	13.2714	7.05726	No	No	No	No	8	7
21	2x39	3x49	bb2_off	17.2061	0	No	No	No	No	8	8
22	2x38	2x42	bb2_off	28.8267	0	Yes	No	Yes	Yes	7	7
23	2x42	3x42	bb2_off	72.2738	0	Yes	Yes	Yes	No	7	8
24	3x42	4x49	bb2_off	78.8533	0	Yes	No	No	No	8	7
25	3x41	4x49	bb2_off	79.6225	1.64559	Yes	No	No	No	5	7
26	3x40	3x41	bb2_off	86.6635	4.91468	No	No	Yes	No	8	5
27	3x40	6x44	bb2_off	88.5451	0	No	No	No	No	8	9
28	3x49	3x50	bb2_off	10.1651	0	No	No	Yes	Yes	8	9
29	3x46	6x37	bb2_off	39.187	0	No	No	No	No	9	8
30	3x50	6x37	bb2_off	12.1117	0	Yes	Yes	No	No	9	8
31	1x39	2x57	bb2_off	26.4422	0	Yes	Yes	No	No	7	7
32	2x57	2x58	bb2_off	25.2174	1.77812	No	No	No	No	7	9
33	2x58	E1x52	bb2_off	23.969	0	No	No	No	Yes	9	7
34	E1x50	E1x52	bb2_off	21.6082	6.69833	Yes	Yes	No	Yes	8	7
35	E1x50	E2.L181	bb2_off	12.5614	0	Yes	Yes	Yes	No	8	4
36	3x33	4x61	bb2_off	13.8927	0	No	No	Yes	Yes	4	5
37	3x33	4x57	bb2_off	12.3839	0	No	No	No	No	4	7
38	3x30	4x57	bb2_off	10.8573	9.50908	Yes	Yes	No	No	6	7
39	3x41	5x461	bb2_off	10.7627	0	Yes	No	No	Yes	5	6
40	5x58	6x37	bb2_off	35.4476	1.55724	Yes	Yes	No	No	8	8
41	3x50	3x53	bb2_off	11.0585	0	Yes	Yes	No	No	9	8
42	6x58	E2.Y199	bb2_off	11.6857	0	No	No	Yes	Yes	4	5
43	E2.Y199	E3.Y291	bb2_off	10.4846	1.46336	Yes	Yes	Yes	Yes	5	1
44	E3.S292	E3.Y291	bb2_off	14.6678	0	No	No	Yes	Yes	1	1
45	6x54	6x58	bb2_off	10.3722	0.110442	No	No	No	No	5	4
46	4x61	Lig	bb2_off	14.7565	2.92672	Yes	Yes	Yes	Yes	5	0
47	6x48	Lig	Shared	81.7407	100	Yes	Yes	Yes	Yes	8	0
48	6x52	Lig	Shared	19.3539	12.3916	No	Yes	Yes	Yes	7	0
49	6x55	Lig	Shared	11.9046	13.4464	Yes	Yes	Yes	Yes	5	0
50	2x54	7x46	Shared	46.3168	14.5673	No	No	Yes	No	6	8
51	6x44	6x48	Shared	86.0363	71.6826	No	No	Yes	Yes	9	8
52	8x50	8x54	Shared	18.9279	16.4946	Yes	No	Yes	Yes	9	7
53	7x45	7x49	Shared	21.2118	38.202	Yes	Yes	No	Yes	9	9
54	2x37	2x40	Shared	14.8985	14.1256	No	No	No	No	8	8
55	2x37	2x39	Shared	16.5138	15.865	No	No	No	No	8	8
56	2x38	3x49	Shared	24.3418	20.8405	Yes	No	No	No	7	8
57	2x42	3x46	Shared	40.2343	34.1101	Yes	Yes	No	No	7	9
58	5x58	5x61	Shared	25.9452	58.5676	Yes	Yes	No	Yes	8	8
59	3x51	5x61	Shared	17.1765	53.5424	Yes	Yes	No	Yes	8	8
60	5x47	6x52	Shared	10.5142	13.2917	Yes	No	No	Yes	8	7
61	7x54	8x54	Shared	11.9165	21.7958	Yes	Yes	Yes	Yes	7	7
62	1x39	7x39	bb2_on	0	18.9243	Yes	Yes	No	No	7	5
63	2x57	7x42	bb2_on	0	12.2481	No	No	Yes	Yes	7	7
64	2x53	Lig	bb2_on	0	19.4158	No	Yes	Yes	Yes	7	0
65	2x53	7x46	bb2_on	2.88149	20.0066	No	Yes	Yes	No	7	8
66	1x46	2x54	bb2_on	0	12.2204	No	No	No	No	8	6
67	1x45	1x46	bb2_on	2.88149	14.9705	No	No	No	No	6	8
68	1x45	7x51	bb2_on	1.4437	10.0226	No	No	No	No	6	5
69	2x50	7x46	bb2_on	8.93438	16.7707	Yes	Yes	Yes	No	9	8
70	6x48	7x45	bb2_on	0	37.1473	Yes	Yes	Yes	Yes	8	9
71	7x49	7x50	bb2_on	0	37.4068	No	Yes	No	No	9	9
72	5x51	6x44	bb2_on	0	79.8774	No	No	No	No	6	9
73	5x51	5x55	bb2_on	0	78.5631	No	No	No	No	6	5
74	5x55	6x41	bb2_on	0	77.9115	No	No	No	No	5	7
75	5x58	6x41	bb2_on	0	74.1178	Yes	Yes	No	No	8	7
76	3x50	5x58	bb2_on	0	42.5921	Yes	Yes	Yes	Yes	9	8
77	3x50	6x40	bb2_on	0	38.5554	Yes	Yes	No	No	9	7
78	6x36	6x40	bb2_on	9.31898	35.2642	No	No	No	No	8	7
79	6x36	7x56	bb2_on	6.9345	33.591	No	No	No	No	8	7
80	6x32	7x56	bb2_on	0	32.089	No	No	No	No	8	7
81	6x32	7x55	bb2_on	0	30.4048	No	No	No	No	8	6
82	7x54	7x55	bb2_on	2.40222	28.7095	Yes	Yes	No	No	7	6
83	1x53	7x50	bb2_on	0	42.2111	No	No	No	No	9	9
84	1x53	2x43	bb2_on	2.39039	39.9083	No	No	No	No	9	8
85	1x56	8x50	bb2_on	0	11.0939	No	No	Yes	No	7	9
86	2x43	3x46	bb2_on	0	39.1352	No	No	No	No	8	9
87	2x42	3x49	bb2_on	0	22.5468	Yes	Yes	No	No	7	8
88	2x38	2x39	bb2_on	0	17.5935	Yes	No	No	No	7	8
89	3x36	Lig	bb2_on	0	46.9987	No	No	Yes	Yes	7	0
90	3x36	3x37	bb2_on	0	38.4726	No	No	No	Yes	7	6
91	3x37	4x53	bb2_on	1.56795	30.9183	No	Yes	No	No	6	8
92	3x38	4x53	bb2_on	0	29.4771	No	No	No	No	7	8
93	3x38	4x50	bb2_on	1.56795	26.5614	No	No	Yes	No	7	9
94	E1x50	Lig	bb2_on	0	12.5076	Yes	Yes	Yes	Yes	8	0
95	E2.F184	Lig	bb2_on	0	19.5869	No	Yes	Yes	Yes	2	0
96	E2.F184	E3.Y291	bb2_on	0	17.61	No	Yes	Yes	Yes	2	1
97	E2.H182	E3.Y291	bb2_on	0	15.3957	No	Yes	Yes	Yes	1	1
98	3x34	4x50	bb2_on	0	23.6015	No	No	Yes	No	5	9
99	3x34	4x54	bb2_on	0	11.0553	No	No	No	No	5	4
100	3x34	4x57	bb2_on	0	11.0553	No	No	No	No	5	7
101	3x30	4x59	bb2_on	6.20673	12.7174	Yes	Yes	No	No	6	4
102	3x51	3x55	bb2_on	4.8222	43.4535	Yes	Yes	No	No	8	7
103	3x55	5x64	bb2_on	3.22466	37.4289	No	No	No	No	7	5
104	E2x52	Lig	bb2_on	2.65073	13.3359	No	No	Yes	Yes	4	0
105	E2.Y199	E2x52	bb2_on	0.183421	12.5021	Yes	Yes	No	No	5	4
106	5x35	E2.Y199	bb2_on	0	10.0668	No	Yes	Yes	Yes	1	5
107	5x47	6x49	bb2_on	4.6802	11.8229	Yes	No	No	No	8	6
108	5x64	5x67	bb2_on	0	35.8993	No	No	No	No	5	4
109	5x67	5x70	bb2_on	0	34.3586	No	No	No	Yes	4	0
110	5x70	6x31	bb2_on	0	25.0483	No	Yes	No	No	0	5
111	6x27	6x31	bb2_on	0	23.6181	No	No	No	No	4	5
112	6x23	6x27	bb2_on	0	22.1658	No	Yes	No	No	0	4
113	7x45	7x48	bb2_on	0	14.352	Yes	Yes	No	No	9	6
114	7x30	Lig	bb2_on	0	10.4534	No	Yes	Yes	Yes	4	0
115	1x38	7x39	bb2_on	0	14.2084	No	No	No	No	6	5
116	7x38	Lig	bb2_on	1.5147	14.3023	No	Yes	Yes	Yes	5	0
117	7x42	Lig	bb2_on	0	19.3219	Yes	Yes	Yes	Yes	7	0
118	3x46	3x50	bb2_on	0	20.9288	No	No	Yes	Yes	9	9

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
3x29	Lig	Shared	10.97	15.255	1	1	1	0
3x32	Lig	Shared	10.38	4.54	0	1	1	0
4x61	Lig	Shared	16.23	4.925	1	1	1	0
E2x52	Lig	Shared	15.54	17.945	1	1	1	0
E2.Y199	Lig	bb2_off	13.06	0	1	1	1	0
5x36	Lig	bb2_off	8.23	0	0	1	1	0
5x39	Lig	bb2_off	7.16	0	1	1	1	0
6x48	Lig	Shared	8.24	4.03	1	1	1	0
6x51	Lig	Shared	4.59	8.165	1	1	1	0
6x52	Lig	Shared	6.44	5.09	1	1	1	0
6x55	Lig	Shared	26.11	5.65	1	1	1	0
7x38	Lig	Shared	10.15	11.69	0	1	1	0
1x35	2x64	Shared	9.67	3.025	0	0	2	1
1x36	2x64	bb2_off	9.74	0	0	0	2	1
1x39	1x43	bb2_off	10.88	0	3	1	2	2
1x39	2x60	Shared	12.64	5.175	3	1	2	1
1x39	7x42	Shared	14.44	4.13	3	1	2	1
1x42	7x42	bb2_off	6.28	0	0	0	2	1
1x43	7x42	bb2_off	7.54	0	3	0	2	1
2x53	3x35	Shared	6.01	3	0	1	1	2
2x53	7x46	Shared	4.5	4.5	0	1	1	2
2x551	3x28	bb2_off	4.56	0	0	0	2	2
2x56	3x32	Shared	4.58	10.68	0	1	1	1
2x63	E1x50	Shared	6	5	0	1	1	1
E1.D104	E2.E186	bb2_off	10.39	0	0	1	1	1
E1x49	E2.F193	bb2_off	4.28	0	0	0	2	1
E1x50	E1x52	Shared	15.03	15.03	2	1	1	2
3x25	E1x50	Shared	3.92	5.22	2	1	2	1
E1x50	E2.L181	bb2_off	4.56	0	2	1	1	2
E1x50	E2x50	Shared	6.53	17.63	2	1	1	1
3x25	E2.L181	Shared	4.76	3.17	2	1	2	2
3x25	E2x50	Shared	7.28	7.28	2	1	2	1
3x28	3x32	Shared	4.12	4.12	0	1	2	1
3x29	4x61	Shared	6.29	3.145	1	1	1	1
3x29	4x65	Shared	5.34	6.235	1	1	1	1
3x33	4x57	bb2_off	4.73	0	0	1	1	2
3x33	4x61	bb2_off	9.28	0	0	1	1	1
3x36	6x48	bb2_off	4.9	0	0	1	1	1
4x61	5x39	Shared	3.69	7.39	1	1	1	1
4x65	E2x52	bb2_off	5.34	0	0	1	1	1
E2.E186	E2.S188	Shared	10.06	4.31	0	1	1	2
E2.E186	E2.T189	Shared	8.47	11.995	0	1	1	2
E2.Q191	E2.T189	Shared	5.67	3.545	0	1	1	2
E2.F193	E2.Q191	bb2_off	15.23	0	0	1	1	1
E2.Y199	E2x52	Shared	5.56	13.91	1	1	1	1
6x58	E2.Y199	bb2_off	4.12	0	0	1	2	1
E2.Y199	E3.Y291	Shared	11.91	15.885	1	1	1	2
5x36	E3.Y291	bb2_off	6.95	0	0	1	1	2
5x39	5x43	Shared	4.18	6.97	1	1	1	2
5x39	6x55	Shared	6.53	4.9	1	1	1	1
5x40	6x59	Shared	6.52	6.52	0	1	2	2
5x43	6x55	Shared	7.63	3.18	1	1	2	1
5x44	5x47	Shared	8.25	8.25	1	1	2	2
5x44	6x52	Shared	6.79	9.615	1	1	2	1
5x47	6x52	Shared	7.62	5.44	1	1	2	1
6x44	6x48	Shared	14.03	13.03	0	1	2	1
6x48	6x51	bb2_off	4.52	0	1	1	1	1
6x48	7x41	bb2_off	6.48	0	1	1	1	2
6x51	7x37	bb2_off	4.69	0	1	1	1	2
6x51	7x41	Shared	4.69	5.47	1	1	1	2
6x54	7x33	Shared	4.56	3.04	0	1	2	2
6x55	6x59	Shared	5.09	6.995	1	1	1	2
7x30	E3.D295	Shared	8.82	3.15	0	1	1	2
7x30	7x33	bb2_off	4.11	0	0	1	1	2
7x30	7x34	Shared	6.97	6.97	0	1	1	2
7x31	7x35	Shared	10.05	7.54	0	1	1	2
1x32	2x64	bb2_off	3.52	0	0	0	2	1
2x59	2x60	bb2_off	2.92	0	0	1	2	1
3x21	E1x50	Shared	2.81	2.81	0	0	2	1
3x24	E1x50	bb2_off	2.81	0	0	0	2	1
1x39	2x57	bb2_off	2.67	0	3	1	2	2
E2.F184	E2.S195	Shared	2.64	4.62	0	1	1	1
6x54	6x58	Shared	2.51	6.26	0	1	2	2
E2.E186	E2.F184	bb2_off	2.33	0	0	1	1	1
E2.P200	Lig	bb2_off	1.83	0	0	0	1	0
5x32	E2.P200	bb2_off	1.63	0	0	0	2	1
E3.T296	E3.V294	bb2_off	1.59	0	0	1	1	1
5x32	E2.S202	bb2_off	1.49	0	0	0	2	2
1x31	1x32	bb2_off	1.43	0	0	0	2	2
7x39	7x42	bb2_off	1.22	0	0	0	2	1
2x64	2x65	bb2_off	1.17	0	0	1	1	2
1x35	1x36	bb2_on	0	3.39	0	0	2	2
1x35	1x39	bb2_on	0	6.045	0	0	2	2
1x39	7x38	bb2_on	0	3.09	3	1	2	1
1x39	7x39	bb2_on	0	11.72	3	1	2	2
1x43	2x57	bb2_on	0	3.25	3	0	2	2
2x53	2x56	bb2_on	0	4.76	0	1	1	1
2x56	7x42	bb2_on	0	4.89	0	1	1	1
2x56	Lig	bb2_on	0	5.545	0	1	1	0
2x57	7x42	bb2_on	0	4.16	0	0	2	1
2x59	E1x52	bb2_on	0	6.555	0	1	2	2
2x59	3x28	bb2_on	0	4.61	0	1	2	2
2x59	3x32	bb2_on	0	4.3	0	1	2	1
2x60	2x63	bb2_on	0	4.17	0	1	1	1
2x60	2x64	bb2_on	0	9.195	0	1	1	1
2x60	7x38	bb2_on	0	4.76	0	1	1	1
2x60	Lig	bb2_on	0	4.69	0	1	1	0
2x63	Lig	bb2_on	0	15.295	0	1	1	0
2x64	7x31	bb2_on	0	5.675	0	1	1	1
2x64	7x34	bb2_on	0	3.18	0	1	1	2
2x64	7x35	bb2_on	0	4.23	0	1	1	2
2x64	Lig	bb2_on	0	14.95	0	1	1	0
E1.D104	E1x49	bb2_on	0	3.57	0	1	1	2
E1.D104	E2.F193	bb2_on	0	4.18	0	1	1	1
E1.D104	Lig	bb2_on	0	4.705	0	1	1	0
E1x50	Lig	bb2_on	0	5.965	2	1	1	0
3x28	E1x52	bb2_on	0	6.28	0	1	2	2
3x28	3x29	bb2_on	0	3.39	0	1	2	1
3x33	5x461	bb2_on	0	8.53	0	1	1	2
3x33	Lig	bb2_on	0	5.04	0	1	1	0
3x36	3x37	bb2_on	0	3.68	0	1	1	2
3x36	5x461	bb2_on	0	4.585	0	1	1	2
3x36	Lig	bb2_on	0	5.51	0	1	1	0
3x37	5x461	bb2_on	0	3.765	0	1	2	2
4x61	4x65	bb2_on	0	4.31	1	1	1	1
4x61	E2x52	bb2_on	0	7.075	1	1	1	1
4x65	Lig	bb2_on	0	4.88	0	1	1	0
E2.H182	E2.P200	bb2_on	0	6.1	0	0	2	1
E2.H182	E3.Y291	bb2_on	0	3.27	0	0	2	2
E2.F184	E2.H201	bb2_on	0	9.615	0	1	1	2
E2.F184	E3.Y291	bb2_on	0	7.735	0	1	1	2
E2.F184	E3.V294	bb2_on	0	3.93	0	1	1	1
E2.F184	Lig	bb2_on	0	15.73	0	1	1	0
E2.E186	E3.T296	bb2_on	0	5.645	0	1	1	1
E2.E186	Lig	bb2_on	0	11.885	0	1	1	0
E2.F193	Lig	bb2_on	0	10.375	0	1	1	0
E2.S195	Lig	bb2_on	0	12.725	0	1	1	0
E2x50	Lig	bb2_on	0	4.45	2	1	1	0
5x35	E2.Y199	bb2_on	0	7.62	0	1	2	1
5x36	E2.Y199	bb2_on	0	12.52	0	1	1	1
6x59	E2.Y199	bb2_on	0	5.725	0	1	2	1
E2.P200	E2.S202	bb2_on	0	3.56	0	0	1	2
E2.H201	E3.Y291	bb2_on	0	22.325	0	1	2	2
5x32	5x35	bb2_on	0	6.38	0	0	2	2
5x35	5x36	bb2_on	0	4.58	0	1	2	1
5x40	6x55	bb2_on	0	5.09	0	1	2	1
6x44	7x45	bb2_on	0	6.04	0	1	2	2
6x48	6x52	bb2_on	0	4.23	1	1	1	1
6x48	7x45	bb2_on	0	9.04	1	1	1	2
6x51	7x38	bb2_on	0	9.04	1	1	1	1
6x54	7x38	bb2_on	0	5.635	0	1	2	1
6x57	E3.D295	bb2_on	0	5.175	0	1	2	2
6x57	7x30	bb2_on	0	3.27	0	1	2	1
6x58	7x30	bb2_on	0	7.9	0	1	2	1
6x58	7x38	bb2_on	0	6.93	0	1	2	1
E3.V294	Lig	bb2_on	0	8.51	0	1	1	0
E3.T296	Lig	bb2_on	0	5.62	0	1	1	0
7x30	Lig	bb2_on	0	3.705	0	1	1	0
7x31	Lig	bb2_on	0	15.535	0	1	1	0
7x42	Lig	bb2_on	0	3.09	3	1	1	0
1x36	2x65	bb2_on	0	4.105	0	0	2	2
2x53	Lig	bb2_on	0	3.535	0	1	1	0
E2.F184	E2.F193	bb2_on	0	3.215	0	1	1	1
E2.E186	E2.F193	bb2_on	0	4.665	0	1	1	1
E2.Q191	Lig	bb2_on	0	4.09	0	1	1	0
1x32	2x65	bb2_on	0	2.075	0	0	2	2
2x551	2x56	bb2_on	0	1.69	0	0	2	1
3x24	E1x52	bb2_on	0	1.51	0	0	2	2
1x31	7x31	bb2_on	0	1.26	0	0	2	1
7x28	7x31	bb2_on	0	1.24	0	0	2	1
E2.E186	E2.E187	bb2_on	0	0.635	0	1	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	bb2_off	7W41-BB₂-PD176252
	bb2_on	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2

Network Difference
Value	bb2_off	bb2_on
I_min	3.63	2.98
Number of Linked Nodes	267	288
Number of Specific Nodes	8 (3.00%)	29 (10.07%)
Number of Shared Nodes	259 (97.00%)	259 (89.93%)
Number of Links	276	342
Number of Specific Links	115 (41.67%)	181 (52.92%)
Number of Shared Links	161 (58.33%)	161 (47.08%)
Number of Hubs	34	45
Number of Specific Hubs	14 (41.18%)	25 (55.56%)
Number of Shared Hubs	20 (58.82%)	20 (44.44%)
Average % Shared Neighbours (Jaccard)	39.30
Average % Shared Neighbours (Otsuka)	48.22
Average % Shared Neighbours (Overlap Coefficient)	57.31
Average % Shared Cliques (k3-6)	51.89
Graphlets Similarity	0.562597

Paths Difference
Value	bb2_off	bb2_on
Number Of Nodes in MetaPath	60	74
Specific Nodes in MetaPath	26 (43.33%)	40 (54.05%)
Shared Nodes in MetaPath	259 (97.00%)	259 (97.00%)
Number Of Links MetaPath	61	72
Specific Links in MetaPath	46 (75.41%)	57 (79.17%)
Shared Links in MetaPath	161 (58.33%)	161 (58.33%)
Number of Shortest Paths	33094	47778
Length Of Smallest Path	3	3
Average Path Length	13.0469	11.9749
Length of Longest Path	31	31
Minimum Path Strength	1.405	1.0725
Average Path Strength	6.87295	5.69302
Maximum Path Strength	21.17	19.105
Minimum Path Correlation	0.7	0.7
Average Path Correlation	0.926774	0.934282
Maximum Path Correlation	0.99	0.99
Minimum % Of Corr. Nodes	4.7619	4.16667
Average % Of Corr. Nodes	54.514	60.8306
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	42.5968	41.5971
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

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