psnGPCR

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Orange: nodes, hubs and links specific of beta1_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of beta1_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	beta1_off Int. Strength	beta1_on Int. Strength	beta1_off Hub1?	beta1_on Hub1?	beta1_off Hub2?	beta1_on Hub2?	ConSurf1	ConSurf2
1	1x31	1x35	beta1_off	100	0	No	No	No	No	3	4
2	1x32	2x65	beta1_off	100	0	No	No	No	No	5	5
3	1x47	2x51	beta1_off	100	0	No	No	No	No	6	7
4	1x50	2x47	beta1_off	100	0	No	No	No	No	9	8
5	1x53	7x50	beta1_off	100	0	No	No	No	No	9	9
6	1x53	7x53	beta1_off	100	0	No	No	Yes	Yes	9	9
7	8x49	I1x50	beta1_off	100	0	No	No	Yes	No	6	8
8	2x38	I2x53	beta1_off	100	0	No	No	Yes	No	6	7
9	2x39	3x50	beta1_off	100	0	No	No	Yes	No	8	9
10	2x42	3x46	beta1_off	100	0	Yes	Yes	No	No	8	9
11	2x42	4x45	beta1_off	100	0	Yes	Yes	No	No	8	6
12	2x43	7x53	beta1_off	100	0	No	No	Yes	Yes	7	9
13	2x53	2x56	beta1_off	100	0	No	No	Yes	No	8	7
14	2x57	7x42	beta1_off	100	0	No	No	Yes	Yes	7	7
15	2x59	E1x52	beta1_off	100	0	No	No	Yes	Yes	4	5
16	2x63	E1x50	beta1_off	100	0	No	No	Yes	Yes	5	7
17	3x30	4x62	beta1_off	100	0	No	No	No	No	6	4
18	3x33	4x57	beta1_off	100	0	No	No	No	No	6	7
19	3x34	4x50	beta1_off	100	0	Yes	No	Yes	Yes	5	9
20	3x37	4x57	beta1_off	100	0	Yes	Yes	No	No	6	7
21	3x38	4x53	beta1_off	100	0	No	No	No	No	7	8
22	3x39	6x44	beta1_off	100	0	No	No	Yes	Yes	9	9
23	3x41	4x53	beta1_off	100	0	Yes	No	No	No	6	8
24	3x43	6x44	beta1_off	100	0	No	No	Yes	Yes	8	9
25	3x46	6x37	beta1_off	100	0	No	No	No	No	9	8
26	3x48	5x57	beta1_off	100	0	No	No	No	No	6	6
27	3x49	3x50	beta1_off	100	0	Yes	Yes	Yes	No	9	9
28	3x50	3x53	beta1_off	100	0	Yes	No	No	No	9	8
29	3x50	I2x53	beta1_off	100	0	Yes	No	Yes	No	9	7
30	3x50	6x34	beta1_off	100	0	Yes	No	No	No	9	7
31	3x51	5x61	beta1_off	100	0	No	Yes	No	No	8	9
32	3x54	5x68	beta1_off	100	0	No	No	Yes	No	9	7
33	3x55	5x64	beta1_off	100	0	No	No	No	No	7	6
34	4x60	E2.W181	beta1_off	100	0	No	No	No	No	7	6
35	4x61	E2x52	beta1_off	100	0	No	No	Yes	No	6	4
36	E2.W182	E2.Y193	beta1_off	100	0	Yes	Yes	Yes	No	5	3
37	E2.W182	E2x52	beta1_off	100	0	Yes	Yes	Yes	No	5	4
38	E2.D186	E2.Q188	beta1_off	100	0	No	No	No	No	1	2
39	E2.A189	E2.Y193	beta1_off	100	0	No	No	Yes	No	4	3
40	5x39	E2x52	beta1_off	100	0	Yes	Yes	Yes	No	7	4
41	5x39	E2.T203	beta1_off	100	0	Yes	Yes	No	No	7	4
42	5x36	5x39	beta1_off	100	0	No	No	Yes	Yes	5	7
43	5x37	E3.R317	beta1_off	100	0	No	No	No	No	5	1
44	5x39	Lig	beta1_off	100	0	Yes	Yes	Yes	Yes	7	0
45	5x41	6x59	beta1_off	100	0	No	No	Yes	No	5	5
46	5x44	5x48	beta1_off	100	0	No	No	Yes	No	6	5
47	5x48	6x52	beta1_off	100	0	Yes	No	Yes	Yes	5	7
48	5x48	6x53	beta1_off	100	0	Yes	No	No	No	5	6
49	5x51	6x45	beta1_off	100	0	No	No	No	No	6	5
50	5x56	5x60	beta1_off	100	0	No	No	No	Yes	5	5
51	5x65	6x31	beta1_off	100	0	No	No	Yes	No	8	5
52	5x68	6x31	beta1_off	100	0	Yes	No	Yes	No	7	5
53	6x35	7x55	beta1_off	100	0	No	No	No	Yes	7	7
54	6x40	7x49	beta1_off	100	0	No	No	No	Yes	8	9
55	6x40	7x52	beta1_off	100	0	No	No	No	No	8	8
56	6x40	7x53	beta1_off	100	0	No	No	Yes	Yes	8	9
57	6x44	6x48	beta1_off	100	0	Yes	Yes	Yes	Yes	9	8
58	6x44	7x45	beta1_off	100	0	Yes	Yes	No	No	9	9
59	6x47	7x40	beta1_off	100	0	No	No	No	No	8	7
60	6x48	Lig	beta1_off	100	0	Yes	Yes	Yes	Yes	8	0
61	6x54	7x37	beta1_off	100	0	No	Yes	No	No	4	5
62	6x59	6x60	beta1_off	100	0	Yes	No	No	No	5	5
63	7x30	7x33	beta1_off	100	0	No	No	Yes	No	5	4
64	7x53	8x50	beta1_off	100	0	Yes	Yes	Yes	Yes	9	8
65	7x54	8x54	beta1_off	100	0	No	No	Yes	No	6	7
66	8x48	8x51	beta1_off	100	0	No	No	No	No	6	8
67	1x32	2x66	beta1_off	100	0	No	No	No	No	5	4
68	3x41	5x50	beta1_off	100	0	Yes	No	No	No	6	9
69	5x68	6x27	beta1_off	100	0	Yes	No	No	No	7	0
70	5x71	5x74	beta1_off	100	0	No	No	No	No	0	0
71	5x72	6x24	beta1_off	100	0	No	No	No	No	0	0
72	6x27	6x31	beta1_off	100	0	No	No	Yes	No	0	5
73	E2.D184	E3.R317	beta1_off	50	0	No	Yes	No	No	4	1
74	3x47	5x57	beta1_off	66.6667	0	No	No	No	No	8	6
75	6x24	6x28	beta1_off	50	0	No	No	No	No	0	0
76	5x72	6x27	beta1_off	33.3333	0	No	No	No	No	0	0
77	1x51	2x51	beta1_off	50	0	No	No	No	No	3	7
78	2x56	3x28	beta1_off	33.3333	0	Yes	No	Yes	Yes	7	6
79	3x23	3x24	beta1_off	50	0	No	No	No	No	2	4
80	3x43	5x54	beta1_off	16.6667	0	No	No	No	No	8	8
81	3x50	6x30	beta1_off	33.3333	0	Yes	No	No	No	9	7
82	3x47	6x41	beta1_off	50	0	No	No	No	No	8	8
83	5x69	6x31	beta1_off	50	0	No	No	Yes	No	5	5
84	6x23	I3.K274	beta1_off	33.3333	0	No	No	No	No	0	0
85	1x56	8x54	beta1_off	16.6667	0	No	No	Yes	No	7	7
86	3x27	3x31	beta1_off	33.3333	0	No	No	No	No	4	5
87	5x61	6x34	beta1_off	16.6667	0	No	No	No	No	9	7
88	6x58	E3.V320	beta1_off	16.6667	0	No	No	Yes	Yes	4	5
89	7x35	7x39	beta1_off	0	0	No	No	Yes	Yes	4	6
90	E2.V202	E2x51	beta1_off	33.3333	0	No	No	No	No	4	5
91	3x44	5x54	beta1_off	33.3333	0	No	No	No	No	6	8
92	2x38	4x39	beta1_off	33.3333	0	No	No	No	No	6	3
93	3x22	E2.P196	beta1_off	50	0	No	No	No	No	4	3
94	1x35	2x65	beta1_off	0	0	No	No	No	No	4	5
95	5x74	I3.K274	beta1_off	33.3333	0	No	No	No	No	0	0
96	6x21	6x22	beta1_off	33.3333	0	No	No	No	No	0	0
97	6x57	E3.L319	beta1_off	33.3333	0	No	No	No	No	5	6
98	6x20	6x22	beta1_off	16.6667	0	No	No	No	No	0	0
99	4x39	I1x51	beta1_off	33.3333	0	No	No	No	No	3	7
100	5x68	6x20	beta1_off	16.6667	0	Yes	No	No	No	7	0
101	E2.E185	E2.L190	beta1_off	33.3333	0	No	No	No	No	2	1
102	5x73	6x24	beta1_off	33.3333	0	No	No	No	No	0	0
103	5x74	I3.S273	beta1_off	33.3333	0	No	No	No	No	0	0
104	6x37	6x38	beta1_off	0	0	No	No	No	No	8	5
105	2x44	2x48	beta1_off	0	0	No	No	No	No	5	5
106	8x48	8x52	beta1_off	16.6667	0	No	No	No	No	6	4
107	6x29	6x32	beta1_off	16.6667	0	No	No	No	No	6	8
108	5x66	5x70	beta1_off	33.3333	0	No	No	No	No	5	0
109	4x56	5x461	beta1_off	0	0	No	No	No	No	5	6
110	2x55	2x551	beta1_off	0	0	No	No	No	No	5	4
111	6x26	I2x54	beta1_off	16.6667	0	No	No	No	No	0	5
112	E2.L190	E2.Y193	beta1_off	0	0	No	No	Yes	No	1	3
113	6x21	I3.S273	beta1_off	16.6667	0	No	No	No	No	0	0
114	6x22	6x26	beta1_off	16.6667	0	No	No	No	No	0	0
115	8x58	CT.F359	beta1_off	33.3333	0	No	No	No	No	6	0
116	4x41	I2x56	beta1_off	16.6667	0	No	No	No	No	7	5
117	6x61	E3.D318	beta1_off	16.6667	0	No	No	No	No	4	2
118	6x25	6x29	beta1_off	16.6667	0	No	No	No	No	0	6
119	6x26	6x29	beta1_off	16.6667	0	No	No	No	No	0	6
120	1x26	1x29	beta1_off	16.6667	0	No	No	No	No	0	0
121	1x29	1x32	beta1_off	16.6667	0	No	No	No	No	0	5
122	1x44	1x48	beta1_off	0	0	No	No	No	No	5	4
123	1x25	1x28	beta1_off	16.6667	0	No	No	No	No	0	0
124	1x38	1x41	beta1_off	0	0	No	No	No	No	5	4
125	1x27	1x30	beta1_off	0	0	No	No	No	No	0	2
126	I2x51	I2x55	beta1_off	16.6667	0	No	No	No	No	6	5
127	1x33	1x34	beta1_off	0	0	No	No	No	No	5	4
128	8x55	8x60	beta1_off	16.6667	0	No	No	No	No	4	7
129	1x34	1x37	beta1_off	0	0	No	No	No	No	4	4
130	7x33	7x36	beta1_off	0	0	Yes	No	No	No	4	5
131	1x30	1x33	beta1_off	0	0	No	No	No	No	2	5
132	1x25	1x29	beta1_off	0	0	No	No	No	No	0	0
133	6x21	I3.A272	beta1_off	0	0	No	No	No	No	0	0
134	7x31	7x35	beta1_off	0	0	No	No	No	No	3	4
135	1x45	7x51	beta1_off	0	0	No	No	No	No	5	6
136	E2.L190	E2.Q194	beta1_off	0	0	No	No	No	No	1	3
137	1x39	2x61	Shared	100	100	No	No	No	No	6	6
138	1x39	7x39	Shared	100	100	No	No	Yes	Yes	6	6
139	1x46	2x54	Shared	100	100	Yes	Yes	No	No	7	7
140	1x46	7x46	Shared	100	100	Yes	Yes	No	No	7	9
141	1x47	2x55	Shared	100	0	No	No	No	No	6	5
142	1x49	7x50	Shared	100	50	No	No	No	No	8	9
143	1x50	2x50	Shared	100	100	No	No	No	Yes	9	9
144	1x50	7x50	Shared	100	100	No	No	No	No	9	9
145	1x52	8x54	Shared	100	100	No	No	Yes	No	6	7
146	1x52	8x58	Shared	100	100	No	No	No	No	6	6
147	1x57	2x40	Shared	100	100	Yes	Yes	Yes	Yes	7	9
148	1x57	2x44	Shared	100	100	Yes	Yes	No	No	7	5
149	1x57	8x50	Shared	100	100	Yes	Yes	Yes	Yes	7	8
150	1x60	I1x50	Shared	100	100	No	No	Yes	No	6	8
151	I1x48	I1x51	Shared	100	100	No	No	No	No	6	7
152	8x49	I1x49	Shared	100	50	No	No	No	No	6	5
153	2x40	I1x50	Shared	100	100	Yes	Yes	Yes	No	9	8
154	8x50	I1x50	Shared	100	100	Yes	Yes	Yes	No	8	8
155	2x37	2x40	Shared	100	100	No	No	Yes	Yes	7	9
156	2x39	3x49	Shared	100	100	No	No	Yes	Yes	8	9
157	2x40	8x50	Shared	100	100	Yes	Yes	Yes	Yes	9	8
158	2x42	3x45	Shared	100	100	Yes	Yes	No	No	8	5
159	2x42	3x49	Shared	100	100	Yes	Yes	Yes	Yes	8	9
160	2x42	4x46	Shared	100	100	Yes	Yes	No	No	8	7
161	2x45	3x42	Shared	100	100	No	No	No	No	9	8
162	2x45	4x46	Shared	100	100	No	No	No	No	9	7
163	2x45	4x50	Shared	100	100	No	No	Yes	Yes	9	9
164	2x46	3x42	Shared	100	100	No	Yes	No	No	9	8
165	2x46	3x43	Shared	100	100	No	Yes	No	No	9	8
166	2x50	7x46	Shared	100	100	No	Yes	No	No	9	9
167	2x50	7x49	Shared	100	100	No	Yes	No	Yes	9	9
168	2x52	3x35	Shared	100	50	No	No	No	No	6	6
169	2x53	3x35	Shared	100	50	No	No	No	No	8	6
170	2x53	7x46	Shared	100	100	No	No	No	No	8	9
171	2x56	3x32	Shared	100	100	Yes	No	No	Yes	7	7
172	2x56	7x42	Shared	100	100	Yes	No	Yes	Yes	7	7
173	2x57	2x58	Shared	100	100	No	No	No	No	7	9
174	2x57	7x39	Shared	100	50	No	No	Yes	Yes	7	6
175	2x59	E1x50	Shared	100	100	No	No	Yes	Yes	4	7
176	2x59	3x28	Shared	100	100	No	No	Yes	Yes	4	6
177	2x60	3x28	Shared	100	100	No	No	Yes	Yes	6	6
178	2x62	E1x52	Shared	100	100	No	No	Yes	Yes	4	5
179	2x64	7x39	Shared	100	50	No	No	Yes	Yes	5	6
180	2x66	E1x51	Shared	100	100	No	No	No	No	4	4
181	E1x50	E1x52	Shared	100	100	Yes	Yes	Yes	Yes	7	5
182	3x25	E1x50	Shared	100	100	No	No	Yes	Yes	9	7
183	3x28	E1x50	Shared	100	100	Yes	Yes	Yes	Yes	6	7
184	E1x50	E2x50	Shared	100	100	Yes	Yes	No	No	7	9
185	E1x51	E1x52	Shared	100	50	No	No	Yes	Yes	4	5
186	3x25	E2x50	Shared	100	100	No	No	No	No	9	9
187	3x26	4x64	Shared	100	100	No	No	No	No	6	5
188	3x29	E2x52	Shared	100	50	No	No	Yes	No	6	4
189	3x30	4x58	Shared	100	100	No	No	No	Yes	6	5
190	3x30	4x61	Shared	100	100	No	No	No	No	6	6
191	3x32	7x42	Shared	100	100	No	Yes	Yes	Yes	7	7
192	3x32	Lig	Shared	100	100	No	Yes	Yes	Yes	7	0
193	3x33	Lig	Shared	100	100	No	No	Yes	Yes	6	0
194	3x34	4x58	Shared	100	100	Yes	No	No	Yes	5	5
195	3x36	6x48	Shared	100	100	No	No	Yes	Yes	6	8
196	3x36	Lig	Shared	100	100	No	No	Yes	Yes	6	0
197	3x37	3x41	Shared	100	100	Yes	Yes	Yes	No	6	6
198	3x37	4x53	Shared	100	100	Yes	Yes	No	No	6	8
199	3x37	5x461	Shared	100	100	Yes	Yes	No	No	6	6
200	3x38	4x50	Shared	100	100	No	No	Yes	Yes	7	9
201	3x40	5x50	Shared	100	50	No	No	No	No	8	9
202	3x40	6x44	Shared	100	100	No	No	Yes	Yes	8	9
203	3x41	4x49	Shared	100	100	Yes	No	No	No	6	6
204	3x41	4x52	Shared	100	100	Yes	No	No	No	6	4
205	3x44	5x53	Shared	100	100	No	No	No	No	6	6
206	3x45	4x45	Shared	100	0	No	No	No	No	5	6
207	3x49	I2x53	Shared	100	100	Yes	Yes	Yes	No	9	7
208	3x51	3x55	Shared	100	100	No	Yes	No	No	8	7
209	3x53	I2x53	Shared	100	100	No	No	Yes	No	8	7
210	3x54	5x64	Shared	100	0	No	No	No	No	9	6
211	3x55	3x56	Shared	100	50	No	No	No	No	7	6
212	I2x53	I2x57	Shared	100	100	Yes	No	No	No	7	6
213	4x38	4x41	Shared	100	50	No	No	No	No	8	7
214	4x56	5x46	Shared	100	100	No	No	No	No	5	4
215	4x61	E2.W182	Shared	100	100	No	No	Yes	Yes	6	5
216	4x63	E2.W181	Shared	100	100	No	No	No	No	5	6
217	4x64	E2.R183	Shared	100	100	No	No	No	Yes	5	4
218	E2.R183	E2.W182	Shared	100	100	No	Yes	Yes	Yes	4	5
219	E2.T203	E2.W182	Shared	100	100	No	No	Yes	Yes	4	5
220	5x39	E2.W182	Shared	100	100	Yes	Yes	Yes	Yes	7	5
221	E2.R183	E2.Y193	Shared	100	100	No	Yes	Yes	No	4	3
222	E2.D184	E2.D186	Shared	100	100	No	Yes	No	No	4	1
223	5x36	E2.D184	Shared	100	50	No	No	No	Yes	5	4
224	E2.D186	E2.P187	Shared	100	100	No	No	No	No	1	1
225	E2.C192	E2.C198	Shared	100	100	No	No	No	No	4	5
226	E2.D195	E2.P196	Shared	100	100	No	No	No	No	3	3
227	E2.D195	E2.G197	Shared	100	100	No	No	No	No	3	4
228	E2.C198	E2.D195	Shared	100	0	No	No	No	No	5	3
229	E2.C198	E2x51	Shared	100	100	No	No	No	No	5	5
230	E2.T203	E2x52	Shared	100	100	No	No	Yes	No	4	4
231	E2x52	Lig	Shared	100	100	Yes	No	Yes	Yes	4	0
232	5x37	6x59	Shared	100	100	No	No	Yes	No	5	5
233	5x39	5x43	Shared	100	100	Yes	Yes	No	No	7	6
234	5x43	Lig	Shared	100	100	No	No	Yes	Yes	6	0
235	5x44	6x52	Shared	100	100	No	No	Yes	Yes	6	7
236	5x461	Lig	Shared	100	100	No	No	Yes	Yes	6	0
237	5x47	5x48	Shared	100	100	No	Yes	Yes	No	7	5
238	5x47	5x51	Shared	100	100	No	Yes	No	No	7	6
239	5x47	6x52	Shared	100	100	No	Yes	Yes	Yes	7	7
240	5x48	6x56	Shared	100	100	Yes	No	No	No	5	5
241	5x49	5x50	Shared	100	50	No	No	No	No	5	9
242	5x51	5x55	Shared	100	100	No	No	No	No	6	5
243	5x54	6x41	Shared	100	100	No	No	No	No	8	8
244	5x62	5x66	Shared	100	100	No	No	No	No	6	5
245	5x64	5x67	Shared	100	0	No	No	No	No	6	4
246	6x36	7x55	Shared	100	0	No	No	No	Yes	8	7
247	6x39	7x52	Shared	100	0	No	No	No	No	7	8
248	6x39	7x55	Shared	100	0	No	No	No	Yes	7	7
249	6x43	7x52	Shared	100	100	No	No	No	No	6	8
250	6x47	7x45	Shared	100	100	No	No	No	No	8	9
251	6x48	6x51	Shared	100	100	Yes	Yes	Yes	Yes	8	7
252	6x48	6x52	Shared	100	100	Yes	Yes	Yes	Yes	8	7
253	6x48	7x41	Shared	100	100	Yes	Yes	No	No	8	6
254	6x49	6x53	Shared	100	100	No	No	No	No	7	6
255	6x50	7x37	Shared	100	100	No	No	No	No	9	5
256	6x51	6x52	Shared	100	100	Yes	Yes	Yes	Yes	7	7
257	6x51	7x34	Shared	100	100	Yes	Yes	No	Yes	7	4
258	6x51	7x38	Shared	100	100	Yes	Yes	No	No	7	6
259	6x51	Lig	Shared	100	100	Yes	Yes	Yes	Yes	7	0
260	6x52	Lig	Shared	100	100	Yes	Yes	Yes	Yes	7	0
261	6x54	E3.V320	Shared	100	100	No	Yes	Yes	Yes	4	5
262	6x54	7x34	Shared	100	100	No	Yes	No	Yes	4	4
263	6x55	7x34	Shared	100	100	No	Yes	No	Yes	6	4
264	6x55	Lig	Shared	100	100	No	Yes	Yes	Yes	6	0
265	6x61	E3.L319	Shared	100	100	No	No	No	No	4	6
266	7x30	E3.V320	Shared	100	100	No	No	Yes	Yes	5	5
267	7x30	7x32	Shared	100	100	No	No	No	No	5	3
268	7x32	7x33	Shared	100	100	No	No	Yes	No	3	4
269	7x33	7x37	Shared	100	100	Yes	No	No	No	4	5
270	7x38	7x42	Shared	100	100	No	No	Yes	Yes	6	7
271	7x38	Lig	Shared	100	100	No	No	Yes	Yes	6	0
272	7x39	7x42	Shared	100	100	Yes	Yes	Yes	Yes	6	7
273	7x42	Lig	Shared	100	100	Yes	Yes	Yes	Yes	7	0
274	7x49	7x53	Shared	100	100	No	Yes	Yes	Yes	9	9
275	8x47	8x48	Shared	100	100	No	No	No	No	8	6
276	8x47	8x50	Shared	100	100	No	No	Yes	Yes	8	8
277	8x50	8x54	Shared	100	100	Yes	Yes	Yes	No	8	7
278	8x51	8x55	Shared	100	100	No	No	No	No	8	4
279	3x34	4x57	Shared	100	100	Yes	No	No	No	5	7
280	5x60	5x63	Shared	100	100	No	Yes	No	No	5	4
281	1x45	7x47	Shared	50	50	No	No	No	No	5	6
282	4x48	4x52	Shared	16.6667	0	No	No	No	No	3	4
283	6x43	7x48	Shared	33.3333	50	No	No	No	No	6	6
284	2x42	4x42	Shared	16.6667	0	Yes	Yes	No	No	8	7
285	1x54	2x47	Shared	83.3333	0	No	No	No	No	7	8
286	1x43	2x58	Shared	83.3333	0	No	No	No	No	5	9
287	5x45	5x49	Shared	0	0	No	No	No	No	4	5
288	3x31	4x58	Shared	50	50	No	No	No	Yes	5	5
289	3x21	E1x50	Shared	0	0	No	No	Yes	Yes	7	7
290	2x551	3x31	Shared	16.6667	100	No	No	No	No	4	5
291	1x46	7x47	Shared	50	0	Yes	Yes	No	No	7	6
292	1x36	2x65	Shared	50	0	No	No	No	No	5	5
293	3x24	E1x52	Shared	16.6667	100	No	No	Yes	Yes	4	5
294	3x56	I2x52	Shared	33.3333	50	No	No	No	No	6	5
295	3x48	3x52	Shared	0	0	No	No	No	No	6	5
296	2x49	4x50	Shared	0	0	No	No	Yes	Yes	8	9
297	E1x49	E1x51	Shared	33.3333	0	No	No	No	No	3	4
298	5x55	5x59	Shared	0	0	No	No	No	No	5	2
299	5x40	6x59	Shared	16.6667	0	No	No	Yes	No	6	5
300	E2.A189	E2.V202	Shared	16.6667	50	No	No	No	No	4	4
301	1x59	8x56	Shared	33.3333	50	No	No	No	No	5	4
302	4x59	4x60	Shared	16.6667	100	No	No	No	No	6	7
303	1x60	8x56	Shared	50	100	No	No	No	No	6	4
304	1x55	8x57	Shared	33.3333	0	No	No	No	No	4	6
305	3x51	5x60	Shared	0	100	No	Yes	No	Yes	8	5
306	2x41	4x39	Shared	33.3333	100	No	No	No	No	5	3
307	1x48	1x49	Shared	0	0	No	No	No	No	4	8
308	6x57	E3.V320	Shared	33.3333	0	No	No	Yes	Yes	5	5
309	4x60	5x39	Shared	0	100	No	No	Yes	Yes	7	7
310	5x36	5x38	Shared	16.6667	0	No	No	No	No	5	4
311	6x42	6x45	Shared	33.3333	0	No	No	No	No	5	5
312	I2x52	I2x56	Shared	33.3333	50	No	No	No	No	5	5
313	1x56	8x53	Shared	0	0	No	No	No	No	7	7
314	3x56	I2x50	Shared	0	0	No	No	No	No	6	8
315	I2x50	I2x51	Shared	33.3333	100	No	No	No	No	8	6
316	4x38	4x40	Shared	0	0	No	No	No	No	8	5
317	4x55	4x59	Shared	16.6667	50	No	No	No	No	4	6
318	5x58	6x41	Shared	0	100	No	Yes	No	No	9	8
319	4x44	4x48	Shared	0	0	No	No	No	No	3	3
320	3x34	4x54	Shared	0	0	Yes	No	No	No	5	3
321	5x67	5x70	Shared	33.3333	0	No	No	No	No	4	0
322	1x42	1x46	Shared	33.3333	0	No	No	Yes	Yes	6	7
323	1x52	8x57	Shared	0	0	No	No	No	No	6	6
324	7x43	7x48	Shared	0	0	No	No	No	No	4	6
325	2x67	E1x49	Shared	0	0	No	No	No	No	4	3
326	1x57	1x58	Shared	16.6667	0	Yes	Yes	No	No	7	2
327	2x41	4x43	Shared	0	50	No	No	No	No	5	4
328	1x35	1x38	Shared	0	50	No	No	No	No	4	5
329	1x53	7x54	beta1_on	0	100	No	No	No	No	9	6
330	2x38	I2x57	beta1_on	0	100	No	No	No	No	6	6
331	2x46	2x50	beta1_on	0	100	No	Yes	No	Yes	9	9
332	2x46	7x49	beta1_on	0	100	No	Yes	No	Yes	9	9
333	2x50	3x39	beta1_on	0	100	No	Yes	No	No	9	9
334	2x51	2x55	beta1_on	0	100	No	No	No	No	7	5
335	2x53	2x54	beta1_on	0	100	No	No	No	No	8	7
336	2x63	Lig	beta1_on	0	100	No	No	Yes	Yes	5	0
337	3x26	E2.R183	beta1_on	0	100	No	No	No	Yes	6	4
338	3x28	Lig	beta1_on	0	100	Yes	Yes	Yes	Yes	6	0
339	3x32	3x36	beta1_on	0	100	No	Yes	No	No	7	6
340	3x40	6x48	beta1_on	0	100	No	No	Yes	Yes	8	8
341	3x43	7x49	beta1_on	0	100	No	No	No	Yes	8	9
342	3x43	7x53	beta1_on	0	100	No	No	Yes	Yes	8	9
343	3x46	3x50	beta1_on	0	100	No	No	Yes	No	9	9
344	3x47	5x58	beta1_on	0	100	No	No	No	Yes	8	9
345	3x49	I2x57	beta1_on	0	100	Yes	Yes	No	No	9	6
346	3x50	5x58	beta1_on	0	100	Yes	No	No	Yes	9	9
347	3x50	7x53	beta1_on	0	100	Yes	No	Yes	Yes	9	9
348	3x51	5x57	beta1_on	0	100	No	Yes	No	No	8	6
349	3x55	5x60	beta1_on	0	100	No	No	No	Yes	7	5
350	4x57	4x58	beta1_on	0	100	No	No	No	Yes	7	5
351	4x61	5x39	beta1_on	0	100	No	No	Yes	Yes	6	7
352	E2.D184	E2.Y193	beta1_on	0	100	No	Yes	Yes	No	4	3
353	E2.V202	E3.R317	beta1_on	0	100	No	No	No	No	4	1
354	5x37	6x60	beta1_on	0	100	No	No	No	No	5	5
355	5x44	6x55	beta1_on	0	100	No	No	No	Yes	6	6
356	5x44	6x56	beta1_on	0	100	No	No	No	No	6	5
357	5x461	6x52	beta1_on	0	100	No	No	Yes	Yes	6	7
358	5x47	6x44	beta1_on	0	100	No	Yes	Yes	Yes	7	9
359	5x47	6x48	beta1_on	0	100	No	Yes	Yes	Yes	7	8
360	5x47	6x49	beta1_on	0	100	No	Yes	No	No	7	7
361	5x51	6x44	beta1_on	0	100	No	No	Yes	Yes	6	9
362	5x54	6x44	beta1_on	0	100	No	No	Yes	Yes	8	9
363	5x58	6x37	beta1_on	0	100	No	Yes	No	No	9	8
364	5x58	6x40	beta1_on	0	100	No	Yes	No	No	9	8
365	5x60	5x64	beta1_on	0	100	No	Yes	No	No	5	6
366	5x62	6x34	beta1_on	0	100	No	No	No	No	6	7
367	5x62	6x37	beta1_on	0	100	No	No	No	No	6	8
368	5x66	6x30	beta1_on	0	100	No	No	No	No	5	7
369	5x69	6x29	beta1_on	0	100	No	No	No	No	5	6
370	6x45	6x49	beta1_on	0	100	No	No	No	No	5	7
371	6x48	7x45	beta1_on	0	100	Yes	Yes	No	No	8	9
372	6x51	6x55	beta1_on	0	100	Yes	Yes	No	Yes	7	6
373	6x54	6x58	beta1_on	0	100	No	Yes	No	No	4	4
374	6x58	E3.R317	beta1_on	0	100	No	No	No	No	4	1
375	6x58	7x34	beta1_on	0	100	No	No	No	Yes	4	4
376	7x33	E3.V320	beta1_on	0	100	Yes	No	Yes	Yes	4	5
377	7x35	Lig	beta1_on	0	100	No	No	Yes	Yes	4	0
378	7x36	7x37	beta1_on	0	100	No	No	No	No	5	5
379	7x36	7x40	beta1_on	0	100	No	No	No	No	5	7
380	7x39	Lig	beta1_on	0	100	Yes	Yes	Yes	Yes	6	0
381	7x45	7x49	beta1_on	0	100	No	No	No	Yes	9	9
382	7x52	7x53	beta1_on	0	100	No	No	Yes	Yes	8	9
383	7x54	8x50	beta1_on	0	100	No	No	Yes	Yes	6	8
384	8x47	8x49	beta1_on	0	100	No	No	No	No	8	6
385	E2.K191	E2.L190	beta1_on	0	100	No	No	No	No	3	1
386	4x59	E2.W181	beta1_on	0	50	No	No	No	No	6	6
387	1x53	2x47	beta1_on	0	50	No	No	No	No	9	8
388	E2.K191	E2.Q188	beta1_on	0	50	No	No	No	No	3	2
389	3x44	3x48	beta1_on	0	0	No	No	No	No	6	6
390	2x37	2x39	beta1_on	0	0	No	No	No	No	7	8
391	5x72	6x29	beta1_on	0	50	No	No	No	No	0	6
392	4x58	4x62	beta1_on	0	50	No	Yes	No	No	5	4
393	5x70	5x71	beta1_on	0	50	No	No	No	No	0	0
394	3x54	5x61	beta1_on	0	0	No	No	No	No	9	9
395	5x73	I3.R247	beta1_on	0	50	No	No	No	No	0	0
396	E3.L319	E3.V320	beta1_on	0	50	No	No	Yes	Yes	6	5
397	1x57	2x43	beta1_on	0	0	Yes	Yes	No	No	7	7
398	5x41	5x45	beta1_on	0	0	No	No	No	No	5	4
399	5x49	5x53	beta1_on	0	0	No	No	No	No	5	6
400	8x52	8x55	beta1_on	0	50	No	No	No	No	4	4
401	2x41	4x46	beta1_on	0	50	No	No	No	No	5	7
402	5x69	6x30	beta1_on	0	50	No	No	No	No	5	7
403	7x55	8x51	beta1_on	0	50	No	Yes	No	No	7	8
404	5x40	E2.T203	beta1_on	0	50	No	No	No	No	6	4
405	5x57	5x58	beta1_on	0	0	No	No	No	Yes	6	9
406	3x27	4x58	beta1_on	0	50	No	No	No	Yes	4	5
407	6x54	6x57	beta1_on	0	0	No	Yes	No	No	4	5
408	I2x55	I2x56	beta1_on	0	50	No	No	No	No	5	5
409	3x22	3x26	beta1_on	0	50	No	No	No	No	4	6
410	3x51	5x56	beta1_on	0	50	No	Yes	No	No	8	5
411	1x50	2x51	beta1_on	0	0	No	No	No	No	9	7
412	5x68	5x71	beta1_on	0	0	Yes	No	No	No	7	0
413	E1x49	E2.G197	beta1_on	0	50	No	No	No	No	3	4
414	5x73	6x29	beta1_on	0	50	No	No	No	No	0	6
415	1x60	8x53	beta1_on	0	0	No	No	No	No	6	7
416	1x58	I1x51	beta1_on	0	0	No	No	No	No	2	7
417	1x47	1x51	beta1_on	0	0	No	No	No	No	6	3
418	3x37	4x56	beta1_on	0	0	Yes	Yes	No	No	6	5
419	6x35	6x39	beta1_on	0	0	No	No	No	No	7	7
420	2x48	4x50	beta1_on	0	0	No	No	Yes	Yes	5	9
421	7x51	7x55	beta1_on	0	0	No	No	No	Yes	6	7
422	7x48	7x51	beta1_on	0	0	No	No	No	No	6	6
423	3x23	3x27	beta1_on	0	0	No	No	No	No	2	4
424	6x31	I3.R247	beta1_on	0	0	Yes	No	No	No	5	0
425	E2.Q194	E2.Y193	beta1_on	0	0	No	No	Yes	No	3	3
426	E2.L190	E2.P187	beta1_on	0	0	No	No	No	No	1	1
427	6x32	6x36	beta1_on	0	0	No	No	No	No	8	8
428	1x43	1x44	beta1_on	0	0	No	No	No	No	5	5
429	1x41	1x44	beta1_on	0	0	No	No	No	No	4	5
430	2x65	2x66	beta1_on	0	0	No	No	No	No	5	4
431	E2.D184	E2.E185	beta1_on	0	0	No	Yes	No	No	4	2
432	4x38	4x39	beta1_on	0	0	No	No	No	No	8	3
433	E3.D318	E3.R317	beta1_on	0	0	No	No	No	No	2	1
434	I2x51	I2x54	beta1_on	0	0	No	No	No	No	6	5

Orange: nodes, hubs and links specific of beta1_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of beta1_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	beta1_off Avg Int. Strength	beta1_on Avg Int. Strength	beta1_off Num Of Links	beta1_on Num Of Links	ConSurf
1	I1x50	beta1_off	16.6667	0	4	3	8
2	2x56	beta1_off	33.3333	0	4	2	7
3	3x34	beta1_off	0	0	4	3	5
4	3x41	beta1_off	66.6667	0	5	3	6
5	3x50	beta1_off	100	0	6	3	9
6	I2x53	beta1_off	100	0	5	3	7
7	E2.Y193	beta1_off	0	0	4	3	3
8	E2x52	beta1_off	100	0	6	3	4
9	5x48	beta1_off	50	0	5	2	5
10	5x68	beta1_off	0	0	4	1	7
11	6x31	beta1_off	33.3333	0	4	1	5
12	6x59	beta1_off	0	0	4	2	5
13	7x33	beta1_off	33.3333	0	4	3	4
14	8x54	beta1_off	0	0	4	2	7
15	1x46	Shared	0	0	4	4	7
16	1x57	Shared	16.6667	0	4	5	7
17	2x40	Shared	33.3333	50	4	4	9
18	2x42	Shared	100	50	6	4	8
19	E1x50	Shared	100	100	7	6	7
20	E1x52	Shared	100	50	5	4	5
21	3x28	Shared	33.3333	50	4	4	6
22	3x37	Shared	50	0	4	4	6
23	3x49	Shared	66.6667	100	4	4	9
24	4x50	Shared	0	0	4	4	9
25	E2.W182	Shared	100	100	6	4	5
26	5x39	Shared	100	100	7	4	7
27	6x44	Shared	100	50	5	4	9
28	6x48	Shared	100	100	6	7	8
29	6x51	Shared	100	100	5	6	7
30	6x52	Shared	100	100	6	6	7
31	E3.V320	Shared	33.3333	50	4	5	5
32	7x39	Shared	83.3333	0	5	5	6
33	7x42	Shared	100	100	6	5	7
34	7x53	Shared	83.3333	100	5	4	9
35	8x50	Shared	100	100	6	6	8
36	Lig	Shared	100	100	13	15	0
37	2x46	beta1_on	0	100	2	4	9
38	2x50	beta1_on	0	100	3	5	9
39	3x32	beta1_on	0	50	3	4	7
40	3x51	beta1_on	0	50	3	4	8
41	4x58	beta1_on	16.6667	50	3	6	5
42	E2.R183	beta1_on	33.3333	50	3	4	4
43	E2.D184	beta1_on	0	0	3	4	4
44	5x47	beta1_on	16.6667	100	3	6	7
45	5x58	beta1_on	0	100	1	6	9
46	5x60	beta1_on	0	50	3	4	5
47	6x54	beta1_on	0	0	3	4	4
48	6x55	beta1_on	0	100	2	4	6
49	7x34	beta1_on	0	50	3	4	4
50	7x49	beta1_on	33.3333	100	3	5	9
51	7x55	beta1_on	0	0	3	4	7

Orange: nodes, hubs and links specific of beta1_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of beta1_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	beta1_off Recurrence	beta1_on Recurrence	beta1_off Hub1?	beta1_on Hub1?	beta1_off Hub2?	beta1_on Hub2?	ConSurf1	ConSurf2
1	1x35	2x65	beta1_off	14.0905	0	No	No	No	No	4	5
2	1x32	2x65	beta1_off	21.0876	0	No	No	No	No	5	5
3	1x32	2x66	beta1_off	36.6533	0	No	No	No	No	5	4
4	2x66	E1x51	beta1_off	40.1348	4.72453	No	No	No	No	4	4
5	2x59	E1x52	beta1_off	31.9886	0	No	No	Yes	Yes	4	5
6	2x59	3x28	beta1_off	33.6781	1.52004	No	No	Yes	Yes	4	6
7	2x56	3x28	beta1_off	77.0397	0	Yes	No	Yes	Yes	7	6
8	2x56	7x42	beta1_off	84.9809	0.663854	Yes	No	Yes	Yes	7	7
9	2x53	2x56	beta1_off	100	0	No	No	Yes	No	8	7
10	2x53	7x46	beta1_off	95.4905	5.80407	No	No	No	No	8	9
11	1x46	7x46	beta1_off	11.0842	7.24656	Yes	Yes	No	No	7	9
12	2x56	3x32	beta1_off	76.4403	1.25946	Yes	No	No	Yes	7	7
13	3x32	Lig	beta1_off	76.8347	1.1695	No	Yes	Yes	Yes	7	0
14	3x33	Lig	beta1_off	73.0271	1.57898	No	No	Yes	Yes	6	0
15	3x33	4x57	beta1_off	72.2258	0	No	No	No	No	6	7
16	3x34	4x57	beta1_off	72.76	0.00310212	Yes	No	No	No	5	7
17	3x34	4x58	beta1_off	14.9011	3.04939	Yes	No	No	Yes	5	5
18	3x31	4x58	beta1_off	15.7583	3.05559	No	No	No	Yes	5	5
19	2x551	3x31	beta1_off	11.2861	1.52935	No	No	No	No	4	5
20	7x42	Lig	beta1_off	83.0243	2.10944	Yes	Yes	Yes	Yes	7	0
21	4x61	E2x52	beta1_off	10.9413	0	No	No	Yes	No	6	4
22	7x53	8x50	beta1_off	49.163	0	Yes	Yes	Yes	Yes	9	8
23	8x50	8x54	beta1_off	16.3608	7.57228	Yes	Yes	Yes	No	8	7
24	8x50	I1x50	beta1_off	10.8451	0.369152	Yes	Yes	Yes	No	8	8
25	3x34	4x50	beta1_off	71.1482	0	Yes	No	Yes	Yes	5	9
26	2x45	4x50	beta1_off	72.4774	6.47413	No	No	Yes	Yes	9	9
27	3x49	I2x53	beta1_off	11.3358	2.98424	Yes	Yes	Yes	No	9	7
28	3x49	3x50	beta1_off	58.9801	0	Yes	Yes	Yes	No	9	9
29	6x48	Lig	beta1_off	21.3361	0	Yes	Yes	Yes	Yes	8	0
30	6x44	6x48	beta1_off	28.0071	0	Yes	Yes	Yes	Yes	9	8
31	3x43	6x44	beta1_off	20.5348	0	No	No	Yes	Yes	8	9
32	2x46	3x43	beta1_off	12.4911	8.53704	No	Yes	No	No	9	8
33	E2.W182	E2x52	beta1_off	16.2303	0	Yes	Yes	Yes	No	5	4
34	5x39	Lig	beta1_off	38.5167	0	Yes	Yes	Yes	Yes	7	0
35	5x461	Lig	beta1_off	14.2458	4.27783	No	No	Yes	Yes	6	0
36	3x37	5x461	beta1_off	12.4942	8.70766	Yes	Yes	No	No	6	6
37	3x43	5x54	beta1_off	11.9041	0	No	No	No	No	8	8
38	3x50	6x34	beta1_off	56.8247	0	Yes	No	No	No	9	7
39	5x61	6x34	beta1_off	55.7502	0	No	No	No	No	9	7
40	3x51	5x61	beta1_off	54.5731	0	No	Yes	No	No	8	9
41	3x51	3x55	beta1_off	49.7904	9.87405	No	Yes	No	No	8	7
42	3x55	5x64	beta1_off	37.495	0	No	No	No	No	7	6
43	3x54	5x64	beta1_off	31.0662	2.54994	No	No	No	No	9	6
44	3x54	5x68	beta1_off	29.7183	0	No	No	Yes	No	9	7
45	3x55	3x56	beta1_off	12.606	8.85656	No	No	No	No	7	6
46	E2.W182	E2.Y193	beta1_off	29.1717	0	Yes	Yes	Yes	No	5	3
47	5x36	5x39	beta1_off	15.9042	0	No	No	Yes	Yes	5	7
48	5x36	E2.D184	beta1_off	13.283	5.87232	No	No	No	Yes	5	4
49	E2.A189	E2.Y193	beta1_off	20.5969	0	No	No	Yes	No	4	3
50	E2.A189	E2.V202	beta1_off	18.3329	1.6069	No	No	No	No	4	4
51	E2.V202	E2x51	beta1_off	16.0626	0	No	No	No	No	4	5
52	E2.C198	E2x51	beta1_off	13.7861	1.57898	No	No	No	No	5	5
53	6x40	7x49	beta1_off	15.5377	0	No	No	No	Yes	8	9
54	6x40	7x52	beta1_off	14.7054	0	No	No	No	No	8	8
55	6x54	7x37	beta1_off	15.5937	0	No	Yes	No	No	4	5
56	6x55	Lig	beta1_off	19.1994	7.29929	No	Yes	Yes	Yes	6	0
57	6x55	7x34	beta1_off	18.1217	6.50205	No	Yes	No	Yes	6	4
58	6x57	E3.V320	beta1_off	12.5439	0.0310212	No	No	Yes	Yes	5	5
59	8x47	8x50	beta1_off	10.8761	6.47413	No	No	Yes	Yes	8	8
60	5x68	6x20	beta1_off	18.1558	0	Yes	No	No	No	7	0
61	6x20	6x22	beta1_off	16.9384	0	No	No	No	No	0	0
62	1x29	1x32	beta1_off	12.5718	0	No	No	No	No	0	5
63	E1x51	E1x52	Shared	50.4954	18.5724	No	No	Yes	Yes	4	5
64	E1x50	E1x52	Shared	32.2277	23.0767	Yes	Yes	Yes	Yes	7	5
65	3x28	E1x50	Shared	40.3895	28.7598	Yes	Yes	Yes	Yes	6	7
66	E2x52	Lig	Shared	29.0537	31.6416	Yes	No	Yes	Yes	4	0
67	3x30	4x61	Shared	15.4601	14.8654	No	No	No	No	6	6
68	3x30	4x58	Shared	13.9073	13.5656	No	No	No	Yes	6	5
69	2x50	7x46	Shared	84.7511	14.3907	No	Yes	No	No	9	9
70	1x50	2x50	Shared	14.0967	11.5616	No	No	No	Yes	9	9
71	2x50	7x49	Shared	69.8624	24.8759	No	Yes	No	Yes	9	9
72	7x49	7x53	Shared	52.7221	32.4358	No	Yes	Yes	Yes	9	9
73	2x45	4x46	Shared	81.1454	65.2252	No	No	No	No	9	7
74	2x42	4x46	Shared	80.105	55.801	Yes	Yes	No	No	8	7
75	2x42	3x49	Shared	72.5333	50.0838	Yes	Yes	Yes	Yes	8	9
76	2x46	3x42	Shared	11.6836	73.2287	No	Yes	No	No	9	8
77	5x39	E2.W182	Shared	17.8981	22.8626	Yes	Yes	Yes	Yes	7	5
78	6x52	Lig	Shared	14.5315	44.0036	Yes	Yes	Yes	Yes	7	0
79	6x51	Lig	Shared	19.2801	35.9722	Yes	Yes	Yes	Yes	7	0
80	6x51	7x34	Shared	28.4636	22.8378	Yes	Yes	No	Yes	7	4
81	6x54	7x34	Shared	43.52	20.2413	No	Yes	No	Yes	4	4
82	6x54	E3.V320	Shared	24.9293	17.3316	No	Yes	Yes	Yes	4	5
83	2x45	3x42	Shared	10.991	71.9103	No	No	No	No	9	8
84	7x39	Lig	beta1_on	0	13.395	Yes	Yes	Yes	Yes	6	0
85	3x36	Lig	beta1_on	1.33855	29.83	No	No	Yes	Yes	6	0
86	3x36	6x48	beta1_on	0.366471	31.8216	No	No	Yes	Yes	6	8
87	6x48	7x45	beta1_on	0	100	Yes	Yes	No	No	8	9
88	7x45	7x49	beta1_on	0	98.6351	No	No	No	Yes	9	9
89	6x48	6x51	beta1_on	4.6399	44.7388	Yes	Yes	Yes	Yes	8	7
90	6x48	6x52	beta1_on	3.42557	33.6084	Yes	Yes	Yes	Yes	8	7
91	2x46	7x49	beta1_on	0	62.8366	No	Yes	No	Yes	9	9
92	2x39	3x49	beta1_on	1.28575	43.5042	No	No	Yes	Yes	8	9
93	2x37	2x39	beta1_on	0	42.0617	No	No	No	No	7	8
94	2x37	2x40	beta1_on	1.86652	40.6006	No	No	Yes	Yes	7	9
95	2x40	8x50	beta1_on	3.53738	20.7501	Yes	Yes	Yes	Yes	9	8
96	5x43	Lig	beta1_on	1.12736	47.3353	No	No	Yes	Yes	6	0
97	5x39	5x43	beta1_on	0.183236	46.1441	Yes	Yes	No	No	7	6
98	4x61	5x39	beta1_on	0	15.402	No	No	Yes	Yes	6	7
99	3x28	Lig	beta1_on	0	32.8453	Yes	Yes	Yes	Yes	6	0
100	E2.T203	E2x52	beta1_on	1.45036	29.3151	No	No	Yes	No	4	4
101	E2.T203	E2.W182	beta1_on	0.307463	23.0798	No	No	Yes	Yes	4	5
102	E2.R183	E2.W182	beta1_on	6.63685	43.1164	No	Yes	Yes	Yes	4	5
103	3x40	6x48	beta1_on	0	15.3555	No	No	Yes	Yes	8	8
104	5x47	6x52	beta1_on	9.33259	18.6469	No	Yes	Yes	Yes	7	7
105	5x47	6x44	beta1_on	0	19.5682	No	Yes	Yes	Yes	7	9
106	3x40	5x50	beta1_on	3.59328	11.6857	No	No	No	No	8	9
107	5x49	5x50	beta1_on	4.45666	10.2463	No	No	No	No	5	9
108	5x54	6x44	beta1_on	0	23.39	No	No	Yes	Yes	8	9
109	5x54	6x41	beta1_on	7.99093	22.8937	No	No	No	No	8	8
110	5x58	6x41	beta1_on	1.34476	22.7292	No	Yes	No	No	9	8
111	5x57	5x58	beta1_on	0	24.5037	No	No	No	Yes	6	9
112	3x51	5x57	beta1_on	0	23.3373	No	Yes	No	No	8	6
113	3x51	5x60	beta1_on	4.32001	11.1025	No	Yes	No	Yes	8	5
114	E2.R183	E2.Y193	beta1_on	0.11491	31.9798	No	Yes	Yes	No	4	3
115	E2.D184	E2.Y193	beta1_on	0	26.2377	No	Yes	Yes	No	4	3
116	E2.D184	E2.D186	beta1_on	4.10572	14.6389	No	Yes	No	No	4	1
117	E2.D186	E2.P187	beta1_on	1.37271	11.7229	No	No	No	No	1	1
118	E1x49	E1x51	beta1_on	7.05923	12.4798	No	No	No	No	3	4
119	5x58	6x37	beta1_on	0	13.1065	No	Yes	No	No	9	8
120	5x62	6x37	beta1_on	0	12.0114	No	No	No	No	6	8
121	7x52	7x53	beta1_on	0	21.8731	No	No	Yes	Yes	8	9
122	6x39	7x52	beta1_on	7.40085	14.0557	No	No	No	No	7	8
123	6x39	7x55	beta1_on	5.55297	11.1614	No	No	No	Yes	7	7
124	3x50	7x53	beta1_on	0	20.9952	Yes	No	Yes	Yes	9	9
125	3x50	5x58	beta1_on	0	18.6717	Yes	No	No	Yes	9	9

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
1x39	7x39	Shared	7.56167	11.05	0	0	2	1
2x56	3x32	Shared	6.81333	7.3	1	1	2	1
2x56	7x42	Shared	5.47	3.79	1	1	2	1
2x57	7x39	Shared	4.08667	3.065	1	0	2	1
2x57	7x42	beta1_off	3.57833	0	1	0	2	1
2x59	E1x50	Shared	5.51167	4.01	1	1	2	2
2x59	3x28	Shared	7.01667	9.02	1	1	2	1
2x60	3x28	Shared	5.16	3.515	0	0	2	1
2x63	E1x50	beta1_off	4.17667	0	0	0	1	2
2x64	7x39	Shared	4.08667	3.065	0	0	2	1
3x28	E1x50	Shared	10.935	7.495	1	1	1	2
3x29	E2x52	Shared	8.43	3.24	0	0	2	1
3x32	7x42	Shared	10.7233	13.215	1	1	1	1
3x32	Lig	Shared	18.98	16.595	1	1	1	0
3x33	4x57	beta1_off	5.385	0	0	0	1	2
3x33	Lig	Shared	11.9817	13.1	0	0	1	0
3x36	6x48	Shared	9.60333	9.81	1	1	1	1
3x36	Lig	Shared	4.42167	6.715	1	1	1	0
3x37	4x57	beta1_off	3.73167	0	4	0	2	2
3x37	5x461	Shared	8.79167	8.79	4	0	2	1
3x40	6x44	Shared	7.15333	5.65	0	0	2	2
4x61	E2.W182	Shared	5.67667	6.46	1	2	2	2
4x61	E2x52	beta1_off	3.55833	0	1	2	2	1
E2.W182	E2x52	beta1_off	10.0233	0	1	2	2	1
E2.T203	E2.W182	Shared	4.045	3.64	1	0	2	2
5x39	E2.W182	Shared	6.43	4.34	1	2	1	2
E2.T203	E2x52	Shared	7.78	3.89	1	0	2	1
5x39	E2x52	beta1_off	5.84667	0	1	2	1	1
E2x52	Lig	Shared	9.54667	19.44	1	0	1	0
5x39	E2.T203	beta1_off	5.615	0	1	2	1	2
5x36	5x39	beta1_off	3.49	0	0	0	2	1
5x39	5x43	Shared	14.8367	8.265	1	2	1	1
5x39	Lig	beta1_off	4.14167	0	1	2	1	0
5x43	Lig	Shared	7.72333	7.38	1	0	1	0
5x44	5x48	beta1_off	3.39	0	1	0	2	2
5x44	6x52	Shared	3.3	4.62	1	0	2	1
5x461	Lig	Shared	3.42667	4.325	0	1	1	0
5x47	5x48	Shared	8.76667	6.705	1	1	2	2
5x47	6x52	Shared	32.15	20.36	1	1	2	1
5x48	6x52	beta1_off	3.26333	0	1	0	2	1
6x44	6x48	beta1_off	10.3567	0	0	1	2	1
6x44	7x45	beta1_off	7.25	0	0	1	2	2
6x48	6x51	Shared	6.01333	6.015	1	1	1	1
6x48	6x52	Shared	5.01	7.52	1	1	1	1
6x48	7x41	Shared	12.2	9.85	1	1	1	2
6x48	Lig	beta1_off	3.93667	0	1	1	1	0
6x51	6x52	Shared	9.29	12.86	1	1	1	1
6x51	7x34	Shared	6.07333	8.035	1	1	1	2
6x51	7x38	Shared	10.4717	13.895	1	1	1	1
6x51	Lig	Shared	9.71833	8.51	1	1	1	0
6x52	Lig	Shared	11.5033	5.985	1	1	1	0
6x55	7x34	Shared	4.23	6.04	0	1	1	2
6x55	Lig	Shared	7.97667	4.615	0	1	1	0
7x38	7x42	Shared	12.9883	13.955	1	1	1	1
7x38	Lig	Shared	12.3017	16.03	1	1	1	0
7x39	7x42	Shared	13.18	6.27	1	1	1	1
7x42	Lig	Shared	4.40833	7.62	1	1	1	0
2x56	3x28	beta1_off	2.86	0	1	1	2	1
7x35	7x39	beta1_off	2.45	0	0	0	1	1
4x60	5x39	Shared	1.85333	4.865	0	0	2	1
4x56	5x461	beta1_off	1.62	0	0	0	2	1
7x31	7x35	beta1_off	0.243333	0	0	0	2	1
2x63	Lig	beta1_on	0	3.68	0	0	1	0
3x28	Lig	beta1_on	0	8.92	1	1	1	0
3x32	3x36	beta1_on	0	3.65	1	1	1	1
3x40	6x48	beta1_on	0	9.395	0	0	2	1
4x61	5x39	beta1_on	0	6.65	1	2	2	1
5x44	6x55	beta1_on	0	5.96	1	0	2	1
5x461	6x52	beta1_on	0	4.625	0	1	1	1
5x47	6x44	beta1_on	0	6.97	1	1	2	2
5x47	6x48	beta1_on	0	4.51	1	1	2	1
6x48	7x45	beta1_on	0	6.78	1	1	1	2
6x51	6x55	beta1_on	0	6.04	1	1	1	1
7x35	Lig	beta1_on	0	3.96	0	0	1	0
7x39	Lig	beta1_on	0	3.785	1	1	1	0
3x37	4x56	beta1_on	0	1.585	4	0	2	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	beta1_off	2VT4-β₁-Cyanopindolol 2YCW-β₁-S-Carazolol 2YCZ-β₁-Iodocyanopindolol 5A8E-β₁-7-Methylcyanopindolol-Na 3ZPQ-β₁-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β₁-4-methyl-2-(piperazin-1-yl)-Na
	beta1_on	8DCR-β₁-Dobutamine-Gs/β1/γ2 7S0F-β₁-Isoprenaline-Gi1/β1/γ2

Network Difference
Value	beta1_off	beta1_on
I_min	3.18667	3.445
Number of Linked Nodes	291	264
Number of Specific Nodes	29 (9.97%)	2 (0.76%)
Number of Shared Nodes	262 (90.03%)	262 (99.24%)
Number of Links	328	298
Number of Specific Links	136 (41.46%)	106 (35.57%)
Number of Shared Links	192 (58.54%)	192 (64.43%)
Number of Hubs	36	37
Number of Specific Hubs	14 (38.89%)	15 (40.54%)
Number of Shared Hubs	22 (61.11%)	22 (59.46%)
Average % Shared Neighbours (Jaccard)	47.00
Average % Shared Neighbours (Otsuka)	55.65
Average % Shared Neighbours (Overlap Coefficient)	63.64
Average % Shared Cliques (k3-6)	55.00
Graphlets Similarity	0.723009

Paths Difference
Value	beta1_off	beta1_on
Number Of Nodes in MetaPath	78	60
Specific Nodes in MetaPath	42 (53.85%)	24 (40.00%)
Shared Nodes in MetaPath	262 (90.03%)	262 (90.03%)
Number Of Links MetaPath	83	63
Specific Links in MetaPath	62 (74.70%)	42 (66.67%)
Shared Links in MetaPath	192 (58.54%)	192 (58.54%)
Number of Shortest Paths	83961	65747
Length Of Smallest Path	3	3
Average Path Length	15.1681	13.8418
Length of Longest Path	36	30
Minimum Path Strength	0.575556	0.7175
Average Path Strength	6.20709	6.37091
Maximum Path Strength	21.9283	22.11
Minimum Path Correlation	0.7	0.7
Average Path Correlation	0.922216	0.921906
Maximum Path Correlation	0.99	0.99
Minimum % Of Corr. Nodes	2.94118	4.16667
Average % Of Corr. Nodes	43.2298	46.28
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	40.2218	46.9698
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download beta1_off_on.zip<

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