psnGPCR

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Orange: nodes, hubs and links specific of beta1_off_allo network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of beta1_off network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	beta1_off_allo Int. Strength	beta1_off Int. Strength	beta1_off_allo Hub1?	beta1_off Hub1?	beta1_off_allo Hub2?	beta1_off Hub2?	ConSurf1	ConSurf2
1	1x29	1x32	beta1_off_allo	3.82	0	No	No	No	No	3	5
2	1x32	2x66	beta1_off_allo	11.63	0	No	No	No	No	5	4
3	1x39	2x64	beta1_off_allo	4.56	0	No	No	No	No	6	5
4	1x42	1x46	beta1_off_allo	3.07	0	No	No	Yes	No	6	7
5	1x43	2x58	beta1_off_allo	3.53	0	No	No	No	No	5	9
6	1x50	2x47	beta1_off_allo	4.69	0	No	No	No	No	9	8
7	1x57	8x50	beta1_off_allo	5.02	0	Yes	No	Yes	Yes	7	8
8	1x59	8x56	beta1_off_allo	6.59	0	No	No	No	No	5	4
9	8x52	I1x49	beta1_off_allo	6.19	0	No	No	No	No	4	5
10	2x40	I1x50	beta1_off_allo	4.12	0	Yes	No	Yes	Yes	9	8
11	4x39	I1x51	beta1_off_allo	7.01	0	No	No	No	No	3	7
12	2x39	6x37	beta1_off_allo	5.9	0	No	No	No	No	8	8
13	2x46	3x39	beta1_off_allo	3	0	No	No	No	No	9	9
14	2x49	Na	beta1_off_allo	3.12	0	No	No	No	No	8	0
15	2x50	Na	beta1_off_allo	8.05	0	Yes	No	No	No	9	0
16	2x57	7x42	beta1_off_allo	3.79	0	Yes	Yes	Yes	Yes	7	7
17	2x59	3x24	beta1_off_allo	3.65	0	Yes	No	No	No	4	4
18	3x27	3x31	beta1_off_allo	4.15	0	No	No	No	No	4	5
19	3x34	4x57	beta1_off_allo	4.5	0	No	No	Yes	No	5	7
20	3x39	Na	beta1_off_allo	5.94	0	No	No	No	No	9	0
21	3x43	5x54	beta1_off_allo	5.65	0	No	No	No	No	8	8
22	3x45	4x45	beta1_off_allo	3.07	0	No	No	No	No	5	6
23	3x54	5x61	beta1_off_allo	4.61	0	No	No	No	No	9	9
24	3x55	5x64	beta1_off_allo	4.23	0	No	No	Yes	No	7	6
25	4x41	I2x57	beta1_off_allo	8.69	0	No	No	No	No	7	6
26	4x59	4x63	beta1_off_allo	4.24	0	Yes	No	No	No	6	5
27	4x59	E2.W181	beta1_off_allo	4.56	0	Yes	No	No	No	6	6
28	E2.A189	E2.D184	beta1_off_allo	4.63	0	No	No	No	No	4	4
29	E2.A189	E2.V202	beta1_off_allo	3.39	0	No	No	No	No	4	4
30	7x31	E2x51	beta1_off_allo	6.91	0	No	No	No	No	3	5
31	E2.T203	Lig	beta1_off_allo	2.98	0	Yes	No	Yes	Yes	4	0
32	5x37	6x60	beta1_off_allo	9.62	0	No	No	No	No	5	5
33	5x41	6x60	beta1_off_allo	3.77	0	No	No	No	No	5	5
34	5x44	6x52	beta1_off_allo	3.96	0	Yes	No	Yes	Yes	6	7
35	5x44	6x55	beta1_off_allo	2.98	0	Yes	No	No	No	6	6
36	5x44	6x56	beta1_off_allo	3.1	0	Yes	No	No	No	6	5
37	5x44	Lig	beta1_off_allo	3.03	0	Yes	No	Yes	Yes	6	0
38	5x47	5x51	beta1_off_allo	7.31	0	Yes	No	Yes	No	7	6
39	5x48	6x53	beta1_off_allo	5.86	0	No	Yes	No	No	5	6
40	5x59	5x60	beta1_off_allo	7.29	0	No	No	No	No	2	5
41	5x61	6x34	beta1_off_allo	2.98	0	No	No	No	No	9	7
42	5x64	5x68	beta1_off_allo	8.92	0	Yes	No	No	No	6	7
43	5x68	6x20	beta1_off_allo	10.51	0	No	No	Yes	No	7	2
44	5x69	6x31	beta1_off_allo	11.93	0	No	No	No	No	5	5
45	5x71	6x24	beta1_off_allo	3.71	0	No	No	No	No	5	3
46	6x20	6x22	beta1_off_allo	12.94	0	Yes	No	No	No	2	4
47	6x20	6x27	beta1_off_allo	7.29	0	Yes	No	Yes	No	2	3
48	6x20	6x30	beta1_off_allo	10.47	0	Yes	No	No	No	2	7
49	6x22	6x26	beta1_off_allo	3.01	0	No	No	No	No	4	4
50	6x22	6x27	beta1_off_allo	7.37	0	No	No	Yes	No	4	3
51	6x23	6x25	beta1_off_allo	6.46	0	No	No	No	No	3	3
52	6x23	6x26	beta1_off_allo	3.07	0	No	No	No	No	3	4
53	6x26	6x29	beta1_off_allo	4.96	0	No	No	No	No	4	6
54	6x27	6x30	beta1_off_allo	3.98	0	Yes	No	No	No	3	7
55	6x36	8x47	beta1_off_allo	6.4	0	No	No	No	No	8	8
56	6x42	6x45	beta1_off_allo	3.64	0	No	No	No	No	5	5
57	6x43	7x52	beta1_off_allo	4.61	0	No	No	No	No	6	8
58	6x48	7x45	beta1_off_allo	4.52	0	Yes	Yes	No	No	8	9
59	6x54	7x37	beta1_off_allo	9.18	0	No	No	No	No	4	5
60	6x58	E3.R317	beta1_off_allo	6.03	0	No	No	No	No	4	1
61	6x58	E3.V320	beta1_off_allo	8.87	0	No	No	Yes	No	4	5
62	6x61	E3.D318	beta1_off_allo	5.39	0	No	No	No	No	4	2
63	1x57	2x43	beta1_off_allo	2.94	0	Yes	No	No	No	7	7
64	5x49	5x53	beta1_off_allo	2.94	0	No	No	No	No	5	6
65	I2x50	I2x51	beta1_off_allo	2.89	0	No	No	No	No	8	6
66	6x20	I2x50	beta1_off_allo	2.88	0	Yes	No	No	No	2	8
67	5x71	6x27	beta1_off_allo	2.82	0	No	No	Yes	No	5	3
68	7x54	8x51	beta1_off_allo	2.79	0	No	No	No	No	6	8
69	1x37	1x41	beta1_off_allo	2.77	0	No	No	No	No	4	4
70	1x56	8x50	beta1_off_allo	2.77	0	No	No	Yes	Yes	7	8
71	1x56	8x54	beta1_off_allo	2.77	0	No	No	No	No	7	7
72	2x55	2x551	beta1_off_allo	2.77	0	No	No	No	No	5	4
73	E2.V202	E3.R317	beta1_off_allo	2.62	0	No	No	No	No	4	1
74	7x34	E3.V320	beta1_off_allo	2.62	0	No	Yes	Yes	No	4	5
75	3x51	5x57	beta1_off_allo	2.52	0	No	No	No	No	8	6
76	3x27	4x58	beta1_off_allo	2.44	0	No	No	No	No	4	5
77	3x31	4x58	beta1_off_allo	2.44	0	No	No	No	No	5	5
78	8x56	8x57	beta1_off_allo	2.43	0	No	No	No	No	4	6
79	1x33	1x34	beta1_off_allo	1.95	0	No	No	No	No	5	4
80	1x47	2x54	beta1_off_allo	1.84	0	No	No	No	No	6	7
81	E1x49	E2.G197	beta1_off_allo	1.82	0	No	No	No	No	3	4
82	6x38	6x41	beta1_off_allo	1.75	0	No	No	No	Yes	5	8
83	6x43	6x47	beta1_off_allo	1.71	0	No	No	No	No	6	8
84	6x50	7x40	beta1_off_allo	1.64	0	No	No	No	No	9	7
85	4x56	4x57	beta1_off_allo	1.62	0	No	No	Yes	No	5	7
86	2x64	2x65	beta1_off_allo	1.6	0	No	No	No	No	5	5
87	2x41	4x42	beta1_off_allo	1.58	0	No	No	No	No	5	7
88	5x65	6x34	beta1_off_allo	1.58	0	No	No	No	No	8	7
89	1x38	1x42	beta1_off_allo	1.49	0	No	No	No	No	5	6
90	4x62	4x63	beta1_off_allo	1.44	0	No	No	No	No	4	5
91	1x41	1x44	beta1_off_allo	1.38	0	No	No	No	No	4	5
92	E2.L190	E2.Q194	beta1_off_allo	1.33	0	No	No	No	No	1	3
93	2x65	2x66	beta1_off_allo	1.31	0	No	No	No	No	5	4
94	7x55	8x51	beta1_off_allo	1.07	0	No	Yes	No	No	7	8
95	1x31	1x35	Shared	12.8	10.47	No	No	No	No	3	4
96	1x35	2x65	Shared	4.56	2.28	No	No	No	No	4	5
97	1x39	2x61	Shared	6.44	4.025	No	No	No	No	6	6
98	1x39	7x39	Shared	8.14	3.49	No	No	Yes	Yes	6	6
99	1x43	2x57	Shared	3.21	3.21	No	No	Yes	Yes	5	7
100	1x45	7x47	Shared	3.15	2.365	No	No	No	No	5	6
101	1x46	2x54	Shared	5.29	5.29	Yes	No	No	No	7	7
102	1x46	7x46	Shared	4.64	4.64	Yes	No	No	No	7	9
103	1x47	2x51	Shared	4.47	2.98	No	No	No	No	6	7
104	1x47	2x55	Shared	4.47	4.47	No	No	No	No	6	5
105	1x49	7x50	Shared	4.06	4.06	No	No	No	Yes	8	9
106	1x50	2x50	Shared	13.46	8.08	No	No	Yes	No	9	9
107	1x50	7x50	Shared	9.77	8.96	No	No	No	Yes	9	9
108	1x51	2x51	Shared	2.98	4.47	No	No	No	No	3	7
109	1x52	8x58	Shared	5.54	2.765	No	No	No	No	6	6
110	1x53	7x50	Shared	3.53	3.53	No	No	No	Yes	9	9
111	1x53	7x53	Shared	4.47	4.42	No	No	No	Yes	9	9
112	1x54	2x47	Shared	3.25	3.25	No	No	No	No	7	8
113	1x57	2x40	Shared	8.5	3.54	Yes	No	Yes	No	7	9
114	1x57	2x44	Shared	3.04	4.56	Yes	No	No	No	7	5
115	1x59	1x60	Shared	4.8	0.8	No	No	No	Yes	5	6
116	1x60	I1x50	Shared	8.84	8.845	No	Yes	Yes	Yes	6	8
117	1x60	8x56	Shared	5.17	0.645	No	Yes	No	No	6	4
118	8x49	I1x49	Shared	10.72	12.51	No	No	No	No	6	5
119	8x50	I1x50	Shared	9.74	9.74	Yes	Yes	Yes	Yes	8	8
120	2x37	2x40	Shared	7.31	10.235	No	No	Yes	No	7	9
121	2x38	I2x53	Shared	5.86	4.69	No	No	Yes	Yes	6	7
122	2x39	3x50	Shared	6.47	9.705	No	No	Yes	Yes	8	9
123	2x40	8x50	Shared	7.25	4.225	Yes	No	Yes	Yes	9	8
124	2x41	4x39	Shared	9.72	1.82	No	No	No	No	5	3
125	2x42	3x45	Shared	3.93	7.21	Yes	Yes	No	No	8	5
126	2x42	3x46	Shared	5.02	3.765	Yes	Yes	No	No	8	9
127	2x42	3x49	Shared	8.36	3.585	Yes	Yes	No	Yes	8	9
128	2x42	4x46	Shared	5.02	4.395	Yes	Yes	No	No	8	7
129	2x45	3x42	Shared	9.59	4	No	No	No	No	9	8
130	2x45	4x46	Shared	6.19	6.195	No	No	No	No	9	7
131	2x45	4x50	Shared	6.18	5.56	No	No	No	Yes	9	9
132	2x46	3x42	Shared	4.42	4.425	No	No	No	No	9	8
133	2x46	3x43	Shared	4.15	4.155	No	No	No	No	9	8
134	2x50	7x46	Shared	8.83	10.305	Yes	No	No	No	9	9
135	2x50	7x49	Shared	4.04	5.385	Yes	No	No	Yes	9	9
136	2x52	3x35	Shared	5.12	3.42	No	No	No	No	6	6
137	2x53	3x35	Shared	3.42	3.42	No	No	No	No	8	6
138	2x53	7x46	Shared	8.08	6.46	No	No	No	No	8	9
139	2x56	3x28	Shared	3.68	3.065	No	Yes	Yes	Yes	7	6
140	2x56	3x32	Shared	7.3	6.57	No	Yes	No	No	7	7
141	2x56	7x42	Shared	3.79	5.68	No	Yes	Yes	Yes	7	7
142	2x57	2x58	Shared	3.53	3.53	Yes	Yes	No	No	7	9
143	2x57	7x39	Shared	4.9	3.675	Yes	Yes	Yes	Yes	7	6
144	2x59	E1x50	Shared	5.01	5.51	Yes	No	Yes	Yes	4	7
145	2x59	E1x52	Shared	12.03	6.01	Yes	No	Yes	Yes	4	5
146	2x59	3x28	Shared	12.03	5.515	Yes	No	Yes	Yes	4	6
147	2x60	3x28	Shared	4.22	4.925	No	No	Yes	Yes	6	6
148	2x62	E1x52	Shared	7.28	11.525	No	No	Yes	Yes	4	5
149	2x63	E1x50	Shared	4.56	6.83	No	No	Yes	Yes	5	7
150	2x64	7x39	Shared	3.68	3.68	No	No	Yes	Yes	5	6
151	E1x50	E1x52	Shared	11.25	11.715	Yes	Yes	Yes	Yes	7	5
152	3x25	E1x50	Shared	5.22	3.92	No	No	Yes	Yes	9	7
153	3x28	E1x50	Shared	13.12	12.185	Yes	Yes	Yes	Yes	6	7
154	E1x50	E2x50	Shared	11.75	13.06	Yes	Yes	No	No	7	9
155	E1x51	E1x52	Shared	10.25	6.265	No	No	Yes	Yes	4	5
156	3x23	3x24	Shared	3.65	3.045	No	No	No	No	2	4
157	3x25	E2x50	Shared	7.28	7.28	No	No	No	No	9	9
158	3x26	4x64	Shared	4.92	10.465	No	Yes	No	No	6	5
159	3x29	E2x52	Shared	7.78	6.485	No	No	Yes	Yes	6	4
160	3x30	4x58	Shared	10.57	11.23	No	No	No	No	6	5
161	3x30	4x61	Shared	4.64	6.19	No	No	No	Yes	6	6
162	3x32	7x42	Shared	10.34	10.34	No	No	Yes	Yes	7	7
163	3x32	Lig	Shared	18.28	18.89	No	No	Yes	Yes	7	0
164	3x33	4x57	Shared	4.85	5.655	No	No	Yes	No	6	7
165	3x33	Lig	Shared	11.04	8.67	No	No	Yes	Yes	6	0
166	3x34	4x50	Shared	5.69	5.69	No	No	No	Yes	5	9
167	3x36	6x48	Shared	13.48	11.65	No	No	Yes	Yes	6	8
168	3x36	Lig	Shared	4.01	3.655	No	No	Yes	Yes	6	0
169	3x37	3x41	Shared	4.23	4.23	Yes	Yes	Yes	Yes	6	6
170	3x37	4x53	Shared	6.4	6.4	Yes	Yes	No	No	6	8
171	3x37	4x57	Shared	4.8	6.395	Yes	Yes	Yes	No	6	7
172	3x37	5x461	Shared	9.59	7.995	Yes	Yes	No	No	6	6
173	3x38	4x50	Shared	9.08	7.78	No	No	No	Yes	7	9
174	3x38	4x53	Shared	3.42	3.42	No	No	No	No	7	8
175	3x40	5x50	Shared	7.07	6.77	No	No	No	No	8	9
176	3x40	5x51	Shared	2.98	3.57	No	No	Yes	No	8	6
177	3x40	6x44	Shared	3.93	8.165	No	No	Yes	Yes	8	9
178	3x41	4x49	Shared	4.28	7.845	Yes	Yes	No	No	6	6
179	3x41	4x52	Shared	6.83	6.835	Yes	Yes	No	No	6	4
180	3x41	4x53	Shared	7.19	10.06	Yes	Yes	No	No	6	8
181	3x43	6x44	Shared	7.31	6.09	No	No	Yes	Yes	8	9
182	3x44	5x53	Shared	3.27	3.27	No	No	No	No	6	6
183	3x46	6x37	Shared	4.28	2.855	No	No	No	No	9	8
184	3x47	5x57	Shared	3.39	2.545	No	No	No	No	8	6
185	3x48	5x57	Shared	3.07	4.605	No	No	No	No	6	6
186	3x49	3x50	Shared	9.53	13.1	No	Yes	Yes	Yes	9	9
187	3x49	I2x53	Shared	11.49	8.05	No	Yes	Yes	Yes	9	7
188	3x50	3x53	Shared	5.53	4.15	Yes	Yes	No	No	9	8
189	3x50	I2x53	Shared	5.14	3.6	Yes	Yes	Yes	Yes	9	7
190	3x50	6x34	Shared	3.64	3.64	Yes	Yes	No	No	9	7
191	3x51	3x55	Shared	8.74	8.115	No	No	No	No	8	7
192	3x51	5x61	Shared	3.79	3.79	No	No	No	No	8	9
193	3x53	I2x53	Shared	8.01	8.675	No	No	Yes	Yes	8	7
194	3x54	5x64	Shared	4.1	2.735	No	No	Yes	No	9	6
195	3x55	3x56	Shared	3.2	4.8	No	No	No	No	7	6
196	I2x53	I2x57	Shared	13.17	11.97	Yes	Yes	No	No	7	6
197	4x41	I2x56	Shared	4.86	1.82	No	No	No	No	7	5
198	4x48	4x52	Shared	3.04	3.04	No	No	No	No	3	4
199	4x56	5x46	Shared	3.07	4.61	No	No	No	No	5	4
200	4x59	4x60	Shared	4.93	1.64	Yes	No	No	No	6	7
201	4x60	E2.W181	Shared	4.05	1.35	No	No	No	No	7	6
202	4x61	E2.W182	Shared	5.87	4.7	No	Yes	Yes	Yes	6	5
203	4x63	E2.W181	Shared	10.47	13.38	No	No	No	No	5	6
204	4x64	E2.R183	Shared	15.8	16.925	No	No	No	Yes	5	4
205	E2.R183	E2.W182	Shared	15.99	11.495	No	Yes	Yes	Yes	4	5
206	E2.W182	E2.Y193	Shared	8.68	5.305	Yes	Yes	Yes	Yes	5	3
207	E2.W182	E2x52	Shared	11.02	10.02	Yes	Yes	Yes	Yes	5	4
208	E2.T203	E2.W182	Shared	3.64	5.46	Yes	No	Yes	Yes	4	5
209	5x39	E2.W182	Shared	6.75	5.79	Yes	Yes	Yes	Yes	7	5
210	E2.R183	E2.Y193	Shared	13.38	18.005	No	Yes	Yes	Yes	4	3
211	E2.E185	E2.L190	Shared	9.28	2.655	No	No	No	No	2	1
212	E2.D186	E2.P187	Shared	11.27	8.855	No	No	No	No	1	1
213	E2.D186	E2.Q188	Shared	5.22	7.83	No	No	No	No	1	2
214	E2.A189	E2.Y193	Shared	4	4	No	No	Yes	Yes	4	3
215	E2.C192	E2.C198	Shared	7.28	7.28	No	No	No	No	4	5
216	E2.V202	E2.Y193	Shared	3.79	2.52	No	No	Yes	Yes	4	3
217	E2.D195	E2.P196	Shared	6.44	4.83	No	No	No	No	3	3
218	E2.D195	E2.G197	Shared	3.35	4.19	No	No	No	No	3	4
219	E2.C198	E2.D195	Shared	4.67	5.445	No	No	No	No	5	3
220	E2.C198	E2x51	Shared	4.67	6.22	No	No	No	No	5	5
221	E2.T203	E2x52	Shared	7.78	7.78	Yes	No	Yes	Yes	4	4
222	5x39	E2x52	Shared	6.19	5.16	Yes	Yes	Yes	Yes	7	4
223	E2x52	Lig	Shared	9.02	8.87	Yes	Yes	Yes	Yes	4	0
224	5x39	E2.T203	Shared	6.24	5.615	Yes	Yes	Yes	No	7	4
225	5x36	5x39	Shared	3.49	3.49	No	No	Yes	Yes	5	7
226	5x39	5x43	Shared	15.26	15.26	Yes	Yes	No	No	7	6
227	5x39	Lig	Shared	5.53	4.09	Yes	Yes	Yes	Yes	7	0
228	5x40	6x59	Shared	5.09	1.7	No	No	No	Yes	6	5
229	5x43	Lig	Shared	7.08	7.87	No	No	Yes	Yes	6	0
230	5x461	Lig	Shared	4.04	3.645	No	No	Yes	Yes	6	0
231	5x47	5x48	Shared	7.22	8.25	Yes	No	No	Yes	7	5
232	5x47	6x49	Shared	3.65	3.045	Yes	No	No	No	7	7
233	5x47	6x52	Shared	34.29	32.15	Yes	No	Yes	Yes	7	7
234	5x48	6x52	Shared	4.13	4.125	No	Yes	Yes	Yes	5	7
235	5x49	5x50	Shared	3.39	5.08	No	No	No	No	5	9
236	5x51	5x55	Shared	4.28	6.425	Yes	No	No	No	6	5
237	5x51	6x45	Shared	4.42	4.42	Yes	No	No	No	6	5
238	5x54	6x41	Shared	11.55	7.22	No	No	No	Yes	8	8
239	5x60	5x63	Shared	17.06	2.665	No	No	No	No	5	4
240	5x65	6x31	Shared	7.32	2.925	No	No	No	No	8	5
241	5x66	5x70	Shared	7.43	1.855	No	No	No	No	5	5
242	6x24	6x28	Shared	7.44	2.48	No	No	No	No	3	5
243	6x25	6x29	Shared	5.23	2.615	No	No	No	No	3	6
244	6x35	6x39	Shared	4.36	4.36	No	No	No	No	7	7
245	6x39	7x52	Shared	5.89	5.89	No	No	No	No	7	8
246	6x40	7x49	Shared	8.5	6.37	No	No	No	Yes	8	9
247	6x43	7x48	Shared	4.56	3.8	No	No	No	No	6	6
248	6x44	6x48	Shared	13.03	9.52	Yes	Yes	Yes	Yes	9	8
249	6x44	7x45	Shared	7.25	6.645	Yes	Yes	No	No	9	9
250	6x47	7x45	Shared	7.87	9.45	No	No	No	No	8	9
251	6x48	6x51	Shared	6.01	6.515	Yes	Yes	Yes	Yes	8	7
252	6x48	6x52	Shared	6.01	5.51	Yes	Yes	Yes	Yes	8	7
253	6x48	7x41	Shared	11.26	12.67	Yes	Yes	No	No	8	6
254	6x48	Lig	Shared	3.84	3.59	Yes	Yes	Yes	Yes	8	0
255	6x49	6x53	Shared	8.3	5.54	No	No	No	No	7	6
256	6x51	6x52	Shared	8.57	8.575	Yes	Yes	Yes	Yes	7	7
257	6x51	7x34	Shared	4.29	4.825	Yes	Yes	No	Yes	7	4
258	6x51	7x38	Shared	12.08	11.48	Yes	Yes	No	No	7	6
259	6x51	Lig	Shared	9.02	9.81	Yes	Yes	Yes	Yes	7	0
260	6x52	Lig	Shared	10.66	11.885	Yes	Yes	Yes	Yes	7	0
261	6x54	E3.V320	Shared	4.81	4.01	No	No	Yes	No	4	5
262	6x55	Lig	Shared	7.4	7.625	No	No	Yes	Yes	6	0
263	6x57	E3.L319	Shared	4.47	1.49	No	No	No	No	5	6
264	6x57	E3.V320	Shared	3.21	1.605	No	No	Yes	No	5	5
265	6x59	6x60	Shared	3.93	3.275	No	Yes	No	No	5	5
266	6x61	E3.L319	Shared	9.61	10.985	No	No	No	No	4	6
267	7x30	7x32	Shared	4.05	10.135	No	No	No	No	5	3
268	7x30	7x33	Shared	3.28	3.285	No	No	No	Yes	5	4
269	7x32	7x33	Shared	3.42	9.11	No	No	No	Yes	3	4
270	7x33	7x37	Shared	8.53	11.57	No	Yes	No	No	4	5
271	7x38	7x42	Shared	12.79	11.63	No	No	Yes	Yes	6	7
272	7x38	Lig	Shared	13.87	14.855	No	No	Yes	Yes	6	0
273	7x39	7x42	Shared	14.47	12.055	Yes	Yes	Yes	Yes	6	7
274	7x42	Lig	Shared	5.53	3.665	Yes	Yes	Yes	Yes	7	0
275	7x53	8x50	Shared	8.53	6.19	No	Yes	Yes	Yes	9	8
276	7x54	8x54	Shared	5.59	2.79	No	No	No	No	6	7
277	8x50	8x54	Shared	4.29	6.43	Yes	Yes	No	No	8	7
278	5x41	5x45	Shared	2.94	2.94	No	No	No	No	5	4
279	5x45	5x49	Shared	2.94	2.94	No	No	No	No	4	5
280	6x50	7x37	Shared	2.89	9.39	No	No	No	No	9	5
281	5x55	5x59	Shared	2.85	2.14	No	No	No	No	5	2
282	3x21	E1x50	Shared	2.81	2.81	No	No	Yes	Yes	7	7
283	4x60	5x39	Shared	2.78	2.085	No	No	Yes	Yes	7	7
284	1x52	8x57	Shared	2.77	2.075	No	No	No	No	6	6
285	2x42	4x42	Shared	2.77	3.465	Yes	Yes	No	No	8	7
286	8x49	I1x50	Shared	2.71	5.43	No	No	Yes	Yes	6	8
287	E2.D184	E2.D186	Shared	2.66	3.99	No	No	No	No	4	1
288	3x56	I2x52	Shared	2.64	1.98	No	No	No	No	6	5
289	8x47	8x50	Shared	2.64	5.945	No	No	Yes	Yes	8	8
290	5x64	5x67	Shared	2.54	6.98	Yes	No	No	No	6	4
291	7x35	7x39	Shared	2.45	2.45	No	No	Yes	Yes	4	6
292	3x23	3x27	Shared	2.44	2.435	No	No	No	No	2	4
293	E2.L190	E2.Y193	Shared	2.34	2.34	No	No	Yes	Yes	1	3
294	5x56	5x60	Shared	2.14	9.62	No	No	No	No	5	5
295	1x48	1x49	Shared	1.95	1.95	No	No	No	No	4	8
296	1x56	8x53	Shared	1.79	1.79	No	No	No	No	7	7
297	8x47	8x48	Shared	1.78	3.56	No	No	No	No	8	6
298	2x44	2x48	Shared	1.69	1.69	No	No	No	No	5	5
299	4x38	4x40	Shared	1.68	1.68	No	No	No	No	8	5
300	1x58	I1x51	Shared	1.64	1.64	No	No	No	No	2	7
301	1x46	7x47	Shared	1.62	3.25	Yes	No	No	No	7	6
302	4x56	5x461	Shared	1.62	1.62	No	No	No	No	5	6
303	5x58	6x41	Shared	1.61	1.61	No	No	No	Yes	9	8
304	4x44	4x48	Shared	1.59	1.59	No	No	No	No	3	3
305	1x44	1x48	Shared	1.58	1.58	No	No	No	No	5	4
306	1x55	8x57	Shared	1.58	0.79	No	No	No	No	4	6
307	3x34	4x54	Shared	1.58	1.58	No	No	No	No	5	3
308	5x36	5x38	Shared	1.56	2.345	No	No	No	No	5	4
309	1x30	1x33	Shared	1.52	1.52	No	No	No	No	2	5
310	I2x55	I2x56	Shared	1.5	0.75	No	No	No	No	5	5
311	E1x49	E1x51	Shared	1.47	2.21	No	No	No	No	3	4
312	3x48	3x52	Shared	1.43	2.85	No	No	No	No	6	5
313	4x55	4x59	Shared	1.38	1.38	No	No	Yes	No	4	6
314	4x38	4x41	Shared	1.29	6.47	No	No	No	No	8	7
315	8x51	8x55	Shared	1.24	5.57	No	No	No	No	8	4
316	1x32	2x65	beta1_off	0	4.275	No	No	No	No	5	5
317	1x52	8x54	beta1_off	0	9.745	No	No	No	No	6	7
318	1x53	2x47	beta1_off	0	3.39	No	No	No	No	9	8
319	1x60	I1x49	beta1_off	0	4.525	No	Yes	No	No	6	5
320	I1x48	I1x51	beta1_off	0	4.48	No	No	No	No	6	7
321	2x39	3x49	beta1_off	0	3.615	No	No	No	Yes	8	9
322	2x43	7x53	beta1_off	0	9.065	No	No	No	Yes	7	9
323	2x53	2x56	beta1_off	0	5.615	No	No	No	Yes	8	7
324	2x551	3x31	beta1_off	0	3.46	No	No	No	No	4	5
325	2x66	E1x51	beta1_off	0	4.25	No	No	No	No	4	4
326	3x22	E2.P196	beta1_off	0	4.45	No	No	No	No	4	3
327	3x26	4x62	beta1_off	0	4.74	No	Yes	No	No	6	4
328	3x26	E2.W182	beta1_off	0	6.54	No	Yes	Yes	Yes	6	5
329	3x26	E2.R183	beta1_off	0	4.65	No	Yes	No	Yes	6	4
330	3x30	4x62	beta1_off	0	5.37	No	No	No	No	6	4
331	3x33	4x61	beta1_off	0	3.84	No	No	No	Yes	6	6
332	3x39	6x44	beta1_off	0	3.96	No	No	Yes	Yes	9	9
333	3x42	4x49	beta1_off	0	3.17	No	No	No	No	8	6
334	3x44	5x54	beta1_off	0	3.24	No	No	No	No	6	8
335	3x47	6x41	beta1_off	0	3.22	No	No	No	Yes	8	8
336	3x54	5x68	beta1_off	0	6.175	No	No	No	No	9	7
337	4x58	4x62	beta1_off	0	4.98	No	No	No	No	5	4
338	4x61	E2x52	beta1_off	0	4.395	No	Yes	Yes	Yes	6	4
339	5x36	E2.D184	beta1_off	0	4.04	No	No	No	No	5	4
340	E2.C192	E2x51	beta1_off	0	3.89	No	No	No	No	4	5
341	5x37	6x59	beta1_off	0	3.92	No	No	No	Yes	5	5
342	5x37	E3.R317	beta1_off	0	6.93	No	No	No	No	5	1
343	5x41	6x59	beta1_off	0	3.84	No	No	No	Yes	5	5
344	5x44	5x48	beta1_off	0	3.815	Yes	No	No	Yes	6	5
345	5x48	6x56	beta1_off	0	7.855	No	Yes	No	No	5	5
346	5x62	5x66	beta1_off	0	8.36	No	No	No	No	6	5
347	6x29	6x32	beta1_off	0	4.95	No	No	No	No	6	8
348	6x35	7x55	beta1_off	0	12.375	No	No	No	Yes	7	7
349	6x36	7x55	beta1_off	0	9.705	No	No	No	Yes	8	7
350	6x39	7x55	beta1_off	0	5.635	No	No	No	Yes	7	7
351	6x40	7x52	beta1_off	0	5.89	No	No	No	No	8	8
352	6x40	7x53	beta1_off	0	6.645	No	No	No	Yes	8	9
353	6x47	7x40	beta1_off	0	3.17	No	No	No	No	8	7
354	6x47	7x48	beta1_off	0	3.24	No	No	No	No	8	6
355	6x54	7x34	beta1_off	0	5.24	No	No	No	Yes	4	4
356	6x55	7x34	beta1_off	0	4.23	No	No	No	Yes	6	4
357	7x30	E3.V320	beta1_off	0	6.185	No	No	Yes	No	5	5
358	7x49	7x50	beta1_off	0	3.26	No	Yes	No	Yes	9	9
359	7x49	7x53	beta1_off	0	6.975	No	Yes	No	Yes	9	9
360	8x48	8x51	beta1_off	0	5.765	No	No	No	No	6	8
361	3x50	6x30	beta1_off	0	4.07	Yes	Yes	No	No	9	7
362	6x26	I2x54	beta1_off	0	4.76	No	No	No	No	4	5
363	5x68	6x27	beta1_off	0	3.325	No	No	Yes	No	7	3
364	2x42	4x45	beta1_off	0	3.14	Yes	Yes	No	No	8	6
365	5x72	6x24	beta1_off	0	3.13	No	No	No	No	0	3
366	5x68	6x31	beta1_off	0	3.095	No	No	No	No	7	5
367	3x54	3x55	beta1_off	0	3.04	No	No	No	No	9	7
368	6x58	7x34	beta1_off	0	3.02	No	No	No	Yes	4	4
369	3x46	6x41	beta1_off	0	2.92	No	No	No	Yes	9	8
370	E2.V202	E2x51	beta1_off	0	2.92	No	No	No	No	4	5
371	1x35	1x39	beta1_off	0	2.89	No	No	No	No	4	6
372	3x24	E1x52	beta1_off	0	2.85	No	No	Yes	Yes	4	5
373	I2x51	I2x52	beta1_off	0	2.67	No	No	No	No	6	5
374	5x56	5x57	beta1_off	0	2.62	No	No	No	No	5	6
375	2x49	4x50	beta1_off	0	2.59	No	No	No	Yes	8	9
376	8x48	8x52	beta1_off	0	2.51	No	No	No	No	6	4
377	6x27	I2x50	beta1_off	0	2.465	Yes	No	No	No	3	8
378	8x58	CT.F359	beta1_off	0	2.435	No	No	No	No	6	0
379	1x50	2x51	beta1_off	0	2.06	No	No	No	No	9	7
380	3x51	5x60	beta1_off	0	2.06	No	No	No	No	8	5
381	I2x51	I2x55	beta1_off	0	1.98	No	No	No	No	6	5
382	8x55	8x60	beta1_off	0	1.86	No	No	No	No	4	0
383	2x38	4x39	beta1_off	0	1.82	No	No	No	No	6	3
384	2x67	E1x49	beta1_off	0	1.82	No	No	No	No	4	3
385	E3.D318	E3.R317	beta1_off	0	1.785	No	No	No	No	2	1
386	6x41	6x42	beta1_off	0	1.75	No	Yes	No	No	8	5
387	6x37	6x38	beta1_off	0	1.71	No	No	No	No	8	5
388	7x43	7x48	beta1_off	0	1.61	No	No	No	No	4	6
389	1x56	I1x50	beta1_off	0	1.58	No	No	Yes	Yes	7	8
390	8x53	I1x50	beta1_off	0	1.58	No	No	Yes	Yes	7	8
391	7x33	7x36	beta1_off	0	1.58	No	Yes	No	No	4	5
392	2x52	2x551	beta1_off	0	1.49	No	No	No	No	6	4
393	2x52	3x31	beta1_off	0	1.49	No	No	No	No	6	5
394	5x69	5x72	beta1_off	0	1.47	No	No	No	No	5	0
395	1x32	1x36	beta1_off	0	1.44	No	No	No	No	5	5
396	6x26	6x27	beta1_off	0	1.415	No	No	Yes	No	4	3
397	1x38	1x41	beta1_off	0	1.38	No	No	No	No	5	4
398	1x57	I1x51	beta1_off	0	1.37	Yes	No	No	No	7	7
399	5x67	5x71	beta1_off	0	1.35	No	No	No	No	4	5
400	1x34	1x37	beta1_off	0	0.855	No	No	No	No	4	4
401	1x42	1x43	beta1_off	0	0.8	No	No	No	No	6	5
402	1x42	2x57	beta1_off	0	0.8	No	No	Yes	Yes	6	7
403	6x25	I3.K274	beta1_off	0	0.76	No	No	No	No	3	0
404	2x41	4x43	beta1_off	0	0.705	No	No	No	No	5	4
405	6x24	I3.A272	beta1_off	0	0.69	No	No	No	No	3	0
406	6x32	7x55	beta1_off	0	0.62	No	No	No	Yes	8	7
407	5x70	5x71	beta1_off	0	0.62	No	No	No	No	5	5

Orange: nodes, hubs and links specific of beta1_off_allo network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of beta1_off network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	beta1_off_allo Avg Int. Strength	beta1_off Avg Int. Strength	beta1_off_allo Num Of Links	beta1_off Num Of Links	ConSurf
1	1x46	beta1_off_allo	3.655	4.39333	4	3	7
2	1x57	beta1_off_allo	4.875	3.15667	4	3	7
3	2x40	beta1_off_allo	6.795	6	4	3	9
4	2x50	beta1_off_allo	8.595	7.92333	4	3	9
5	2x59	beta1_off_allo	8.18	5.67833	4	3	4
6	4x57	beta1_off_allo	3.9425	6.025	4	2	7
7	4x59	beta1_off_allo	3.7775	1.51	4	2	6
8	E2.T203	beta1_off_allo	5.16	6.285	4	3	4
9	5x44	beta1_off_allo	3.2675	3.815	4	1	6
10	5x47	beta1_off_allo	13.1175	14.4817	4	3	7
11	5x51	beta1_off_allo	4.7475	4.805	4	3	6
12	5x64	beta1_off_allo	4.9475	4.8575	4	2	6
13	6x20	beta1_off_allo	8.818	0	5	0	2
14	6x27	beta1_off_allo	5.365	2.40167	4	3	3
15	E3.V320	beta1_off_allo	4.8775	3.93333	4	3	5
16	I1x50	Shared	6.3525	5.435	4	5	8
17	2x42	Shared	5.02	4.26	5	6	8
18	2x57	Shared	3.8575	2.80375	4	4	7
19	E1x50	Shared	7.67429	8.00429	7	7	7
20	E1x52	Shared	10.2025	7.673	4	5	5
21	3x28	Shared	8.2625	6.4225	4	4	6
22	3x37	Shared	6.255	6.255	4	4	6
23	3x41	Shared	5.6325	7.2425	4	4	6
24	3x50	Shared	6.062	6.3775	5	6	9
25	I2x53	Shared	8.734	7.397	5	5	7
26	E2.W182	Shared	8.65833	7.04429	6	7	5
27	E2.Y193	Shared	6.438	6.434	5	5	3
28	E2x52	Shared	8.358	7.11833	5	6	4
29	5x39	Shared	6.60571	5.92714	7	7	7
30	6x44	Shared	7.88	6.876	4	5	9
31	6x48	Shared	8.30714	8.2425	7	6	8
32	6x51	Shared	7.994	8.241	5	5	7
33	6x52	Shared	11.27	12.449	6	5	7
34	7x39	Shared	6.728	5.07	5	5	6
35	7x42	Shared	8.45167	8.674	6	5	7
36	8x50	Shared	5.74857	6.506	7	5	8
37	Lig	Shared	7.68867	8.24	15	13	0
38	1x60	beta1_off	6.27	3.70375	3	4	6
39	2x56	beta1_off	4.92333	5.2325	3	4	7
40	3x26	beta1_off	4.92	6.59875	1	4	6
41	3x49	beta1_off	9.79333	7.0875	3	4	9
42	4x50	beta1_off	6.98333	5.405	3	4	9
43	4x61	beta1_off	5.255	4.78125	2	4	6
44	E2.R183	beta1_off	15.0567	12.7687	3	4	4
45	5x48	beta1_off	5.73667	6.01125	3	4	5
46	6x41	beta1_off	4.97	3.344	3	5	8
47	6x59	beta1_off	4.51	3.18375	2	4	5
48	7x33	beta1_off	5.07667	6.38625	3	4	4
49	7x34	beta1_off	3.455	4.32875	2	4	4
50	7x49	beta1_off	6.27	5.4975	2	4	9
51	7x50	beta1_off	5.78667	4.9525	3	4	9
52	7x53	beta1_off	6.5	6.659	2	5	9
53	7x55	beta1_off	1.07	7.08375	1	4	7

Orange: nodes, hubs and links specific of beta1_off_allo network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of beta1_off network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	beta1_off_allo Recurrence	beta1_off Recurrence	beta1_off_allo Hub1?	beta1_off Hub1?	beta1_off_allo Hub2?	beta1_off Hub2?	ConSurf1	ConSurf2
1	2x64	2x65	beta1_off_allo	10.6272	0	No	No	No	No	5	5
2	2x64	7x39	beta1_off_allo	12.1811	0.694956	No	No	Yes	Yes	5	6
3	2x46	3x39	beta1_off_allo	99.5878	0	No	No	No	No	9	9
4	3x39	Na	beta1_off_allo	98.2511	0	No	No	No	No	9	0
5	2x50	Na	beta1_off_allo	95.5442	0	Yes	No	No	No	9	0
6	1x46	7x46	beta1_off_allo	21.3156	5.74215	Yes	No	No	No	7	9
7	1x46	2x54	beta1_off_allo	11.7912	1.43968	Yes	No	No	No	7	7
8	1x53	7x50	beta1_off_allo	54.6396	8.53119	No	No	No	Yes	9	9
9	1x53	7x53	beta1_off_allo	52.9687	4.49049	No	No	No	Yes	9	9
10	1x60	I1x50	beta1_off_allo	13.6683	5.50619	No	Yes	Yes	Yes	6	8
11	3x33	Lig	beta1_off_allo	63.6627	3.22593	No	No	Yes	Yes	6	0
12	3x33	4x57	beta1_off_allo	62.5097	5.78086	No	No	Yes	No	6	7
13	3x34	4x57	beta1_off_allo	64.7154	0	No	No	Yes	No	5	7
14	3x34	4x50	beta1_off_allo	63.6126	1.61665	No	No	No	Yes	5	9
15	2x42	4x42	beta1_off_allo	10.3877	1.82864	Yes	Yes	No	No	8	7
16	3x49	3x50	beta1_off_allo	62.5933	6.87767	No	Yes	Yes	Yes	9	9
17	E2.R183	E2.W182	beta1_off_allo	13.1447	4.14762	No	Yes	Yes	Yes	4	5
18	E2.T203	Lig	beta1_off_allo	28.1274	0	Yes	No	Yes	Yes	4	0
19	E2.T203	E2.W182	beta1_off_allo	26.8241	0.0423979	Yes	No	Yes	Yes	4	5
20	4x61	E2.W182	beta1_off_allo	18.8593	4.15684	No	Yes	Yes	Yes	6	5
21	3x30	4x61	beta1_off_allo	14.9716	4.09785	No	No	No	Yes	6	6
22	3x30	4x58	beta1_off_allo	11.4849	1.41019	No	No	No	No	6	5
23	3x40	5x50	beta1_off_allo	19.3773	7.57447	No	No	No	No	8	9
24	6x52	Lig	beta1_off_allo	14.1807	3.94669	Yes	Yes	Yes	Yes	7	0
25	5x47	6x52	beta1_off_allo	13.3118	2.27105	Yes	No	Yes	Yes	7	7
26	5x47	5x51	beta1_off_allo	10.9224	0	Yes	No	Yes	No	7	6
27	5x49	5x50	beta1_off_allo	17.4891	6.83343	No	No	No	No	5	9
28	3x50	6x34	beta1_off_allo	59.14	1.60743	Yes	Yes	No	No	9	7
29	5x61	6x34	beta1_off_allo	52.5175	0	No	No	No	No	9	7
30	3x51	5x61	beta1_off_allo	15.7514	1.85813	No	No	No	No	8	9
31	3x54	5x61	beta1_off_allo	35.0061	0	No	No	No	No	9	9
32	I2x53	I2x57	beta1_off_allo	12.4262	1.85813	Yes	Yes	No	No	7	6
33	4x41	I2x57	beta1_off_allo	10.3821	0	No	No	No	No	7	6
34	4x60	5x39	beta1_off_allo	13.5402	4.82783	No	No	Yes	Yes	7	7
35	E2.A189	E2.Y193	beta1_off_allo	22.4685	2.11068	No	No	Yes	Yes	4	3
36	E2.A189	E2.D184	beta1_off_allo	18.3525	0	No	No	No	No	4	4
37	E2.L190	E2.Y193	beta1_off_allo	13.8298	4.21951	No	No	Yes	Yes	1	3
38	E2.D184	E2.D186	beta1_off_allo	13.7797	2.90702	No	No	No	No	4	1
39	E1x49	E1x51	beta1_off_allo	48.9306	5.6426	No	No	No	No	3	4
40	E1x49	E2.G197	beta1_off_allo	42.7983	0	No	No	No	No	3	4
41	E2.D195	E2.G197	beta1_off_allo	36.6548	2.11068	No	No	No	No	3	4
42	E2.C198	E2.D195	beta1_off_allo	24.3344	8.42612	No	No	No	No	5	3
43	5x45	5x49	beta1_off_allo	11.7578	6.0887	No	No	No	No	4	5
44	5x64	5x68	beta1_off_allo	29.9822	0	Yes	No	No	No	6	7
45	5x68	6x20	beta1_off_allo	28.0327	0	No	No	Yes	No	7	2
46	6x20	6x22	beta1_off_allo	12.3259	0	Yes	No	No	No	2	4
47	6x22	6x26	beta1_off_allo	10.4378	0	No	No	No	No	4	4
48	6x47	7x45	beta1_off_allo	11.6242	3.8324	No	No	No	No	8	9
49	6x51	Lig	beta1_off_allo	17.2106	7.75881	Yes	Yes	Yes	Yes	7	0
50	7x34	E3.V320	beta1_off_allo	31.3022	0	No	Yes	Yes	No	4	5
51	6x54	7x37	beta1_off_allo	14.4313	0	No	No	No	No	4	5
52	6x48	6x51	beta1_off_allo	13.4956	2.43143	Yes	Yes	Yes	Yes	8	7
53	7x39	7x42	Shared	18.9763	10.9147	Yes	Yes	Yes	Yes	6	7
54	7x42	Lig	Shared	67.7955	69.2026	Yes	Yes	Yes	Yes	7	0
55	6x48	Lig	Shared	81.4804	45.1464	Yes	Yes	Yes	Yes	8	0
56	6x44	6x48	Shared	92.0965	47.9778	Yes	Yes	Yes	Yes	9	8
57	3x43	6x44	Shared	99.0197	37.2935	No	No	Yes	Yes	8	9
58	2x46	3x43	Shared	96.1513	36.7995	No	No	No	No	9	8
59	2x50	7x46	Shared	28.7345	86.0032	Yes	No	No	No	9	9
60	1x50	2x50	Shared	69.1768	16.2642	No	No	Yes	No	9	9
61	1x50	7x50	Shared	64.4313	10.0243	No	No	No	Yes	9	9
62	7x53	8x50	Shared	51.2866	41.8283	No	Yes	Yes	Yes	9	8
63	8x50	I1x50	Shared	20.987	12.6493	Yes	Yes	Yes	Yes	8	8
64	2x45	4x50	Shared	68.9874	33.474	No	No	No	Yes	9	9
65	2x45	4x46	Shared	100	100	No	No	No	No	9	7
66	2x42	4x46	Shared	98.5017	98.3539	Yes	Yes	No	No	8	7
67	2x42	3x49	Shared	80.6784	22.6571	Yes	Yes	No	Yes	8	9
68	3x49	I2x53	Shared	16.6091	12.3728	No	Yes	Yes	Yes	9	7
69	2x46	3x42	Shared	44.7588	36.3129	No	No	No	No	9	8
70	2x56	7x42	Shared	52.0887	66.3711	No	Yes	Yes	Yes	7	7
71	2x56	3x28	Shared	95.5052	35.7746	No	Yes	Yes	Yes	7	6
72	2x59	3x28	Shared	41.3947	13.9895	Yes	No	Yes	Yes	4	6
73	3x28	E1x50	Shared	48.3458	19.3334	Yes	Yes	Yes	Yes	6	7
74	2x59	E1x52	Shared	33.7195	12.6051	Yes	No	Yes	Yes	4	5
75	E1x50	E1x52	Shared	33.5357	12.6733	Yes	Yes	Yes	Yes	7	5
76	E1x51	E1x52	Shared	55.0518	11.2723	No	No	Yes	Yes	4	5
77	E2x52	Lig	Shared	29.4865	19.6302	Yes	Yes	Yes	Yes	4	0
78	E2.W182	E2x52	Shared	26.7795	15.3333	Yes	Yes	Yes	Yes	5	4
79	5x39	Lig	Shared	43.3218	26.6885	Yes	Yes	Yes	Yes	7	0
80	5x39	E2.W182	Shared	28.0495	15.6632	Yes	Yes	Yes	Yes	7	5
81	5x461	Lig	Shared	14.6931	69.068	No	No	Yes	Yes	6	0
82	3x37	5x461	Shared	10.8277	67.8735	Yes	Yes	No	No	6	6
83	3x40	6x44	Shared	27.7264	11.2244	No	No	Yes	Yes	8	9
84	3x54	5x64	Shared	33.1124	10.5755	No	No	Yes	No	9	6
85	E2.W182	E2.Y193	Shared	47.1037	24.2221	Yes	Yes	Yes	Yes	5	3
86	E2.C198	E2x51	Shared	11.9695	10.5147	No	No	No	No	5	5
87	6x51	7x34	Shared	33.5357	12.371	Yes	Yes	No	Yes	7	4
88	6x54	E3.V320	Shared	16.7985	15.2798	No	No	Yes	No	4	5
89	2x45	3x42	Shared	43.6115	68.6901	No	No	No	No	9	8
90	3x32	Lig	Shared	47.605	61.3589	No	No	Yes	Yes	7	0
91	2x56	3x32	Shared	46.3072	60.9516	No	Yes	No	No	7	7
92	2x53	2x56	beta1_off	0	97.7824	No	No	No	Yes	8	7
93	2x53	7x46	beta1_off	5.94297	91.9389	No	No	No	No	8	9
94	2x50	7x49	beta1_off	3.97126	69.35	Yes	No	No	Yes	9	9
95	7x49	7x53	beta1_off	0	46.6985	No	Yes	No	Yes	9	9
96	2x40	8x50	beta1_off	3.65378	11.1248	Yes	No	Yes	Yes	9	8
97	3x37	3x41	beta1_off	6.34399	36.4437	Yes	Yes	Yes	Yes	6	6
98	3x41	4x49	beta1_off	1.96614	34.4031	Yes	Yes	No	No	6	6
99	3x42	4x49	beta1_off	0	33.9312	No	No	No	No	8	6
100	3x37	4x53	beta1_off	3.49226	36.4161	Yes	Yes	No	No	6	8
101	3x38	4x53	beta1_off	6.305	35.9018	No	No	No	No	7	8
102	3x38	4x50	beta1_off	5.83714	35.3838	No	No	No	Yes	7	9
103	2x42	3x46	beta1_off	5.80372	70.8708	Yes	Yes	No	No	8	9
104	E2.V202	E2.Y193	beta1_off	7.81441	16.3637	No	No	Yes	Yes	4	3
105	E2.V202	E2x51	beta1_off	0	14.4927	No	No	No	No	4	5
106	3x46	6x41	beta1_off	0	65.8752	No	No	No	Yes	9	8
107	3x47	6x41	beta1_off	0	55.4601	No	No	No	Yes	8	8
108	3x47	5x57	beta1_off	2.09981	53.7163	No	No	No	No	8	6
109	5x56	5x57	beta1_off	0	48.7023	No	No	No	No	5	6
110	5x56	5x60	beta1_off	1.98284	46.9418	No	No	No	No	5	5
111	3x51	5x60	beta1_off	0	43.4099	No	No	No	No	8	5
112	3x51	3x55	beta1_off	6.44982	39.8632	No	No	No	No	8	7
113	3x54	3x55	beta1_off	0	23.9585	No	No	No	No	9	7
114	3x54	5x68	beta1_off	0	11.6778	No	No	No	No	9	7
115	3x55	3x56	beta1_off	4.19405	14.5111	No	No	No	No	7	6
116	3x56	I2x52	beta1_off	2.09981	12.677	No	No	No	No	6	5
117	I2x51	I2x52	beta1_off	0	10.8391	No	No	No	No	6	5
118	6x40	7x49	beta1_off	1.98841	12.8502	No	No	No	Yes	8	9
119	6x40	7x52	beta1_off	0	12.0742	No	No	No	No	8	8
120	6x39	7x52	beta1_off	3.91556	10.6732	No	No	No	No	7	8
121	6x54	7x34	beta1_off	0	16.7877	No	No	No	Yes	4	4

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
2x56	3x32	Shared	6.57	7.3	1	1	2	1
2x56	7x42	Shared	5.68	3.79	1	1	2	1
2x57	7x39	Shared	3.675	4.9	3	1	2	2
3x29	E2x52	Shared	6.485	7.78	0	0	2	1
3x32	7x42	Shared	10.34	10.34	1	1	1	1
3x32	Lig	Shared	18.89	18.28	1	1	1	0
3x33	4x57	Shared	5.655	4.85	0	0	1	2
3x33	4x61	beta1_off	3.84	0	0	0	1	2
3x33	Lig	Shared	8.67	11.04	0	0	1	0
3x36	6x48	Shared	11.65	13.48	1	1	1	1
3x36	Lig	Shared	3.655	4.01	1	1	1	0
3x37	4x57	Shared	6.395	4.8	7	6	2	2
3x37	5x461	Shared	7.995	9.59	7	6	2	1
4x61	E2.W182	Shared	4.7	5.87	1	0	2	2
4x61	E2x52	beta1_off	4.395	0	1	0	2	1
E2.W182	E2x52	Shared	10.02	11.02	1	1	2	1
E2.T203	E2.W182	Shared	5.46	3.64	1	1	1	2
5x39	E2.W182	Shared	5.79	6.75	1	1	1	2
E2.T203	E2x52	Shared	7.78	7.78	1	1	1	1
5x39	E2x52	Shared	5.16	6.19	1	1	1	1
E2x52	Lig	Shared	8.87	9.02	1	1	1	0
5x39	E2.T203	Shared	5.615	6.24	1	1	1	1
5x36	5x39	Shared	3.49	3.49	0	0	2	1
5x39	5x43	Shared	15.26	15.26	1	1	1	1
5x39	Lig	Shared	4.09	5.53	1	1	1	0
5x43	Lig	Shared	7.87	7.08	1	1	1	0
5x44	5x48	beta1_off	3.815	0	0	1	1	2
5x461	Lig	Shared	3.645	4.04	0	0	1	0
5x47	5x48	Shared	8.25	7.22	1	1	2	2
5x47	6x52	Shared	32.15	34.29	1	1	2	1
5x48	6x52	Shared	4.125	4.13	1	1	2	1
5x48	6x56	beta1_off	7.855	0	1	1	2	2
6x44	6x48	Shared	9.52	13.03	0	1	2	1
6x44	7x45	Shared	6.645	7.25	0	1	2	2
6x48	6x51	Shared	6.515	6.01	1	1	1	1
6x48	6x52	Shared	5.51	6.01	1	1	1	1
6x48	7x41	Shared	12.67	11.26	1	1	1	2
6x48	Lig	Shared	3.59	3.84	1	1	1	0
6x51	6x52	Shared	8.575	8.57	1	1	1	1
6x51	7x34	Shared	4.825	4.29	1	1	1	2
6x51	7x38	Shared	11.48	12.08	1	1	1	1
6x51	Lig	Shared	9.81	9.02	1	1	1	0
6x52	Lig	Shared	11.885	10.66	1	1	1	0
6x55	7x34	beta1_off	4.23	0	0	1	1	2
6x55	Lig	Shared	7.625	7.4	0	1	1	0
7x38	7x42	Shared	11.63	12.79	1	1	1	1
7x38	Lig	Shared	14.855	13.87	1	1	1	0
7x39	7x42	Shared	12.055	14.47	0	1	2	1
7x42	Lig	Shared	3.665	5.53	1	1	1	0
4x60	5x39	Shared	2.085	2.78	0	1	2	1
4x56	5x461	Shared	1.62	1.62	0	0	2	1
2x57	7x42	beta1_off_allo	0	3.79	3	1	2	1
E2.T203	Lig	beta1_off_allo	0	2.98	1	1	1	0
5x44	6x52	beta1_off_allo	0	3.96	0	1	1	1
5x44	6x55	beta1_off_allo	0	2.98	0	1	1	1
5x44	6x56	beta1_off_allo	0	3.1	0	1	1	2
5x44	Lig	beta1_off_allo	0	3.03	0	1	1	0
6x48	7x45	beta1_off_allo	0	4.52	1	1	1	2
4x56	4x57	beta1_off_allo	0	1.62	0	0	2	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	beta1_off_allo	4BVN-β₁-Cyanopindolol-Na
	beta1_off	2VT4-β₁-Cyanopindolol 2YCZ-β₁-Iodocyanopindolol

Network Difference
Value	beta1_off_allo	beta1_off
I_min	2.98	3.17
Number of Linked Nodes	268	276
Number of Specific Nodes	7 (2.61%)	15 (5.43%)
Number of Shared Nodes	261 (97.39%)	261 (94.57%)
Number of Links	315	313
Number of Specific Links	94 (29.84%)	92 (29.39%)
Number of Shared Links	221 (70.16%)	221 (70.61%)
Number of Hubs	37	38
Number of Specific Hubs	15 (40.54%)	16 (42.11%)
Number of Shared Hubs	22 (59.46%)	22 (57.89%)
Average % Shared Neighbours (Jaccard)	55.02
Average % Shared Neighbours (Otsuka)	63.97
Average % Shared Neighbours (Overlap Coefficient)	73.62
Average % Shared Cliques (k3-6)	77.99
Graphlets Similarity	0.705707

Paths Difference
Value	beta1_off_allo	beta1_off
Number Of Nodes in MetaPath	87	66
Specific Nodes in MetaPath	42 (48.28%)	21 (31.82%)
Shared Nodes in MetaPath	261 (97.39%)	261 (97.39%)
Number Of Links MetaPath	91	69
Specific Links in MetaPath	52 (57.14%)	30 (43.48%)
Shared Links in MetaPath	221 (70.16%)	221 (70.16%)
Number of Shortest Paths	58113	105385
Length Of Smallest Path	3	3
Average Path Length	14.2537	17.2247
Length of Longest Path	32	39
Minimum Path Strength	1.155	0.7225
Average Path Strength	6.56929	5.79424
Maximum Path Strength	22.475	22.0175
Minimum Path Correlation	0.7	0.7
Average Path Correlation	0.927502	0.919539
Maximum Path Correlation	0.99	0.99
Minimum % Of Corr. Nodes	3.44828	2.77778
Average % Of Corr. Nodes	49.4705	39.7332
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	38.6729	41.5024
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download beta1_off_ortoallo.zip<

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