psnGPCR

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Orange: nodes, hubs and links specific of beta2_off_allo network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of beta2_off network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	beta2_off_allo Int. Strength	beta2_off Int. Strength	beta2_off_allo Hub1?	beta2_off Hub1?	beta2_off_allo Hub2?	beta2_off Hub2?	ConSurf1	ConSurf2
1	1x47	2x51	beta2_off_allo	4.47	0	No	No	Yes	No	6	7
2	1x55	1x59	beta2_off_allo	4.5	0	No	No	No	No	5	5
3	2x40	2x43	beta2_off_allo	5.66	0	Yes	No	No	No	9	8
4	2x46	7x49	beta2_off_allo	5.49	0	No	No	Yes	No	9	9
5	2x50	7x49	beta2_off_allo	6.73	0	No	No	Yes	No	9	9
6	3x26	4x62	beta2_off_allo	7.65	0	No	No	No	No	5	4
7	3x29	4x61	beta2_off_allo	4.56	0	No	No	No	No	4	5
8	3x37	4x57	beta2_off_allo	4.8	0	No	No	No	No	6	7
9	3x41	4x49	beta2_off_allo	5.7	0	No	No	No	No	5	7
10	3x41	4x53	beta2_off_allo	4.31	0	No	No	No	No	5	8
11	3x41	Alloh345	beta2_off_allo	17.18	0	No	No	Yes	No	5	0
12	3x43	5x54	beta2_off_allo	4.24	0	Yes	No	No	No	8	8
13	3x43	6x41	beta2_off_allo	4.24	0	Yes	No	No	No	8	8
14	3x44	Alloh345	beta2_off_allo	11.22	0	No	No	Yes	No	7	0
15	3x46	6x37	beta2_off_allo	4.28	0	No	No	No	No	9	8
16	3x48	5x57	beta2_off_allo	6.41	0	No	No	No	No	6	6
17	3x48	Alloh345	beta2_off_allo	10.54	0	No	No	Yes	No	6	0
18	E2.T195	E2.Y174	beta2_off_allo	4.99	0	Yes	No	Yes	Yes	3	5
19	E2.C184	E2x51	beta2_off_allo	4.67	0	No	No	Yes	No	1	3
20	7x34	E2x52	beta2_off_allo	4.13	0	Yes	No	Yes	Yes	5	4
21	5x37	E3.D300	beta2_off_allo	5.22	0	No	No	No	No	2	1
22	5x49	Alloh345	beta2_off_allo	19.32	0	No	No	Yes	No	5	0
23	5x50	Alloh345	beta2_off_allo	13.55	0	No	Yes	Yes	No	8	0
24	5x53	Alloh345	beta2_off_allo	5.05	0	No	No	Yes	No	6	0
25	5x67	5x68	beta2_off_allo	7.01	0	No	No	No	No	4	7
26	6x43	7x48	beta2_off_allo	5.19	0	No	No	No	No	6	6
27	6x48	7x38	beta2_off_allo	4.52	0	Yes	Yes	Yes	No	8	5
28	6x48	7x45	beta2_off_allo	4.52	0	Yes	Yes	Yes	No	8	9
29	6x51	6x55	beta2_off_allo	12.08	0	Yes	Yes	No	No	6	5
30	7x30	E3.I303	beta2_off_allo	5.01	0	No	No	Yes	Yes	4	3
31	7x34	E3.I303	beta2_off_allo	8.46	0	Yes	No	Yes	Yes	5	3
32	7x30	7x33	beta2_off_allo	7.85	0	No	No	No	No	4	4
33	7x31	7x35	beta2_off_allo	4.36	0	No	No	No	No	2	3
34	6x58	E3.L302	beta2_off_allo	3.86	0	No	No	No	No	3	1
35	2x54	2x57	beta2_off_allo	3.68	0	No	No	No	No	7	7
36	3x50	6x34	beta2_off_allo	3.64	0	Yes	No	No	No	9	7
37	7x45	7x48	beta2_off_allo	3.62	0	Yes	No	No	No	9	6
38	2x57	2x58	beta2_off_allo	3.53	0	No	No	No	No	7	8
39	3x27	4x62	beta2_off_allo	3.51	0	No	Yes	No	No	5	4
40	3x28	Lig	beta2_off_allo	3.43	0	Yes	Yes	Yes	Yes	5	0
41	2x49	3x39	beta2_off_allo	3.42	0	No	No	No	No	8	9
42	1x30	1x32	beta2_off_allo	3.21	0	No	No	Yes	No	2	4
43	4x56	5x461	beta2_off_allo	3.2	0	No	No	No	No	5	5
44	2x46	3x39	beta2_off_allo	3	0	No	No	No	No	9	9
45	5x51	5x55	beta2_off_allo	2.98	0	No	No	No	No	7	5
46	6x45	6x49	beta2_off_allo	2.95	0	No	No	No	No	7	6
47	1x52	8x57	beta2_off_allo	2.77	0	No	No	No	No	6	6
48	2x42	4x42	beta2_off_allo	2.77	0	Yes	Yes	No	No	8	7
49	1x50	2x51	beta2_off_allo	2.75	0	Yes	No	Yes	No	9	7
50	8x49	I1x50	beta2_off_allo	2.71	0	No	No	No	No	7	8
51	1x30	1x31	beta2_off_allo	2.45	0	No	No	No	Yes	2	3
52	1x48	8x58	beta2_off_allo	2.44	0	No	No	No	No	4	6
53	7x47	7x50	beta2_off_allo	2.03	0	No	No	No	No	7	9
54	4x53	4x54	beta2_off_allo	1.86	0	No	No	No	No	8	4
55	5x46	Alloh345	beta2_off_allo	1.76	0	No	No	Yes	No	4	0
56	2x44	2x48	beta2_off_allo	1.69	0	No	No	No	No	6	6
57	5x40	E2.T195	beta2_off_allo	1.68	0	No	No	Yes	No	5	3
58	6x49	6x50	beta2_off_allo	1.64	0	No	No	No	No	6	9
59	4x52	4x56	beta2_off_allo	1.59	0	No	No	No	No	4	5
60	6x53	6x57	beta2_off_allo	1.54	0	No	No	No	No	6	4
61	6x56	6x57	beta2_off_allo	1.54	0	No	No	No	No	6	4
62	1x32	1x35	beta2_off_allo	1.52	0	Yes	No	No	No	4	5
63	1x32	2x67	beta2_off_allo	1.52	0	Yes	No	No	No	4	4
64	2x38	4x39	beta2_off_allo	1.52	0	No	No	No	No	6	1
65	6x57	6x61	beta2_off_allo	1.43	0	No	No	No	No	4	2
66	1x41	1x44	beta2_off_allo	1.38	0	No	No	No	No	5	5
67	4x62	4x63	beta2_off_allo	1.36	0	No	No	No	No	4	4
68	1x32	2x65	Shared	5.96	2.55429	Yes	No	No	No	4	6
69	1x39	2x61	Shared	4.83	4.83	Yes	Yes	No	No	6	6
70	1x39	2x64	Shared	4.37	4.78857	Yes	Yes	No	No	6	5
71	1x39	7x39	Shared	11.63	10.8014	Yes	Yes	No	No	6	5
72	1x43	2x58	Shared	5.3	4.54429	No	No	No	No	6	8
73	1x46	7x46	Shared	6.19	7.07571	No	No	No	No	8	9
74	1x47	2x55	Shared	4.47	4.04429	No	No	No	No	6	5
75	1x50	2x47	Shared	4.69	3.57286	Yes	No	No	No	9	9
76	1x50	2x50	Shared	6.73	8.46286	Yes	No	No	No	9	9
77	1x50	7x50	Shared	4.89	6.98571	Yes	No	No	No	9	9
78	1x51	2x51	Shared	4.47	3.40571	No	No	Yes	No	3	7
79	1x52	8x54	Shared	14.61	8.17857	No	No	Yes	Yes	6	7
80	1x53	7x53	Shared	6.31	6.13	No	No	Yes	Yes	9	9
81	1x55	8x57	Shared	4.42	4	No	No	No	No	5	6
82	1x57	2x40	Shared	7.08	5.66429	No	No	Yes	No	7	9
83	1x57	2x44	Shared	6.08	5.21143	No	No	No	No	7	6
84	1x60	8x53	Shared	5.55	4.35714	No	Yes	No	No	6	7
85	1x60	8x56	Shared	5.83	4.33	No	Yes	No	No	6	4
86	8x50	I1x50	Shared	7.31	5.56857	Yes	Yes	No	No	9	8
87	2x37	2x40	Shared	10.24	8.14429	No	No	Yes	No	7	9
88	2x38	I2x55	Shared	9.7	8.77571	No	No	No	No	6	4
89	2x39	3x50	Shared	6.47	5.72714	No	No	Yes	No	8	9
90	2x40	8x50	Shared	4.83	6.90429	Yes	No	Yes	Yes	9	9
91	2x41	4x39	Shared	14.33	11.9429	No	No	No	No	4	1
92	2x41	4x43	Shared	7.2	10.4371	No	No	No	No	4	3
93	2x42	3x45	Shared	6.55	5.61571	Yes	Yes	No	No	8	7
94	2x42	3x46	Shared	6.28	5.02	Yes	Yes	No	No	8	9
95	2x42	3x49	Shared	8.36	3.92429	Yes	Yes	Yes	Yes	8	8
96	2x42	4x46	Shared	5.02	5.02	Yes	Yes	No	No	8	8
97	2x43	7x53	Shared	14.51	11.3986	No	No	Yes	Yes	8	9
98	2x45	3x42	Shared	4.8	6.39571	No	No	No	No	9	8
99	2x45	4x46	Shared	7.74	7.51857	No	No	No	No	9	8
100	2x46	3x43	Shared	4.15	5.14286	No	No	Yes	No	9	8
101	2x50	7x46	Shared	8.83	9.67429	No	No	No	No	9	9
102	2x51	2x55	Shared	6.92	4.54714	Yes	No	No	No	7	5
103	2x53	2x56	Shared	4.56	5.65286	No	Yes	No	No	7	7
104	2x53	7x46	Shared	7.67	5.69429	No	Yes	No	No	7	9
105	2x56	3x32	Shared	7.3	6.88286	No	No	No	No	7	7
106	2x57	7x42	Shared	5.05	3.96857	No	No	Yes	Yes	7	6
107	2x59	E1x52	Shared	13.93	10.8729	No	No	Yes	Yes	5	5
108	2x59	3x24	Shared	22.05	18.0386	No	No	Yes	Yes	5	5
109	2x59	3x28	Shared	5.01	5.86857	No	No	Yes	Yes	5	5
110	2x60	3x28	Shared	5.63	3.61714	No	No	Yes	Yes	7	5
111	2x63	E1x50	Shared	8.46	8.16143	No	No	Yes	Yes	4	7
112	2x64	7x39	Shared	5.87	4.7	No	No	No	No	5	5
113	2x66	E1x51	Shared	4.52	6.23714	No	No	No	No	4	2
114	E1x49	E1x51	Shared	4.52	3.22857	No	No	No	No	5	2
115	E1x50	E1x52	Shared	9.02	15.4614	Yes	Yes	Yes	Yes	7	5
116	3x24	E1x50	Shared	5.62	4.68571	Yes	Yes	Yes	Yes	5	7
117	3x25	E1x50	Shared	5.22	5.59429	No	No	Yes	Yes	9	7
118	3x28	E1x50	Shared	14.99	11.2471	Yes	Yes	Yes	Yes	5	7
119	E1x50	E2x50	Shared	20.89	16.2329	Yes	Yes	No	No	7	9
120	E1x51	E1x52	Shared	9.08	8.15286	No	No	Yes	Yes	2	5
121	3x24	E1x52	Shared	5.01	4.15286	Yes	Yes	Yes	Yes	5	5
122	3x21	E2.E188	Shared	4.91	2.33857	No	No	No	No	7	3
123	3x22	E2.E188	Shared	6.57	11.8329	No	No	No	No	2	3
124	3x23	3x27	Shared	9.65	2.60286	No	No	No	Yes	1	5
125	3x24	3x28	Shared	4.69	4.95571	Yes	Yes	Yes	Yes	5	5
126	3x25	E2x50	Shared	7.28	7.28	No	No	No	No	9	9
127	3x26	4x64	Shared	4.92	9.67286	No	No	No	No	5	4
128	3x27	3x31	Shared	5.02	5.2	No	Yes	No	No	5	4
129	3x29	E2x52	Shared	5.19	5.74571	No	No	Yes	Yes	4	4
130	3x30	4x58	Shared	5.28	12.2671	No	No	No	No	6	4
131	3x30	4x61	Shared	7.74	7.51857	No	No	No	No	6	5
132	3x32	7x42	Shared	11.49	9.35857	No	No	Yes	Yes	7	6
133	3x32	Lig	Shared	20.43	18.62	No	No	Yes	Yes	7	0
134	3x33	4x57	Shared	6.46	5.99857	No	No	No	No	5	7
135	3x33	Lig	Shared	10.09	10.7643	No	No	Yes	Yes	5	0
136	3x34	4x50	Shared	6.83	6.34286	No	No	No	Yes	5	9
137	3x34	4x57	Shared	6.01	3.64429	No	No	No	No	5	7
138	3x36	6x48	Shared	12.26	7.70571	No	No	Yes	Yes	6	8
139	3x36	Lig	Shared	7.85	6.17571	No	No	Yes	Yes	6	0
140	3x37	4x53	Shared	6.4	4.34286	No	No	No	No	6	8
141	3x37	5x461	Shared	7.99	8.90571	No	No	No	No	6	5
142	3x38	4x50	Shared	7.78	8.33714	No	No	No	Yes	7	9
143	3x40	5x50	Shared	10.16	7.01571	No	No	No	Yes	7	8
144	3x40	6x44	Shared	7.54	6.28	No	No	Yes	Yes	7	9
145	3x43	6x44	Shared	4.87	6.26429	Yes	No	Yes	Yes	8	9
146	3x49	3x50	Shared	5.96	6.63714	Yes	Yes	Yes	No	8	9
147	3x49	I2x55	Shared	8.83	8.83	Yes	Yes	No	No	8	4
148	3x50	3x53	Shared	5.53	4.34714	Yes	No	No	No	9	8
149	3x51	3x52	Shared	6.19	2.94571	No	No	No	No	8	5
150	3x51	3x55	Shared	6.24	10.5243	No	No	No	No	8	7
151	3x51	5x60	Shared	7.2	7.49714	No	No	No	Yes	8	5
152	3x54	5x61	Shared	6.14	2.41571	No	No	No	No	9	8
153	3x54	5x64	Shared	4.1	4.68714	No	No	Yes	Yes	9	5
154	3x56	I2x56	Shared	4.5	5.57857	No	No	No	No	6	4
155	I2x51	I2x54	Shared	4.68	3.51143	No	No	No	No	6	4
156	I2x52	I2x53	Shared	17.91	18.0871	No	No	No	No	5	7
157	5x68	I2x52	Shared	10.85	9.68571	No	No	No	No	7	5
158	6x30	I2x53	Shared	17.96	14.91	No	No	No	No	7	7
159	6x31	I2x53	Shared	9.8	7.15429	Yes	Yes	No	No	5	7
160	4x40	4x43	Shared	4.82	3.27286	No	No	No	No	4	3
161	4x55	4x59	Shared	4.15	1.97714	No	No	No	No	4	5
162	4x60	5x39	Shared	6.95	3.97143	No	No	Yes	Yes	5	6
163	4x61	E2.Y174	Shared	12.09	6.04429	No	No	Yes	Yes	5	5
164	4x63	E2.W173	Shared	10.47	13.13	No	No	No	No	4	4
165	4x64	E2.R175	Shared	23.7	25.1471	No	No	No	Yes	4	2
166	E2.R175	E2.Y174	Shared	16.46	14.11	No	Yes	Yes	Yes	2	5
167	5x39	E2.Y174	Shared	6.95	6.66714	Yes	Yes	Yes	Yes	6	5
168	E2.R175	E2.Y185	Shared	28.81	31.0129	No	Yes	No	No	2	1
169	E2.A181	E2.H178	Shared	7.32	7.32	No	No	No	Yes	4	2
170	E2.F194	E2.H178	Shared	5.66	3.71571	Yes	Yes	No	Yes	1	2
171	E2.N183	E2.Q179	Shared	10.56	6.78857	No	No	No	No	3	3
172	E2.E180	E2.F194	Shared	7	4.33143	No	No	Yes	Yes	3	1
173	E2.A181	E2.Y185	Shared	6.67	4.19143	No	No	No	No	4	1
174	E2.A181	E2.F194	Shared	4.16	5.35143	No	No	Yes	Yes	4	1
175	E2.C184	E2.C190	Shared	7.28	7.28	No	No	No	No	1	3
176	E2.E187	E2.T189	Shared	11.29	7.86143	No	No	No	No	4	4
177	E2.C190	E2x51	Shared	6.22	4.44571	No	No	Yes	No	3	3
178	E2.F194	E2x51	Shared	5.97	6.65571	Yes	Yes	Yes	No	1	3
179	7x31	E2x51	Shared	11.06	5.33429	No	No	Yes	No	2	3
180	E2.T195	E2x52	Shared	6.49	7.78	Yes	No	Yes	Yes	3	4
181	E2x52	Lig	Shared	7.33	9.22143	Yes	Yes	Yes	Yes	4	0
182	5x39	E2.T195	Shared	9.99	5.70714	Yes	Yes	Yes	No	6	3
183	5x37	6x59	Shared	7.16	4.91286	No	No	No	Yes	2	5
184	5x39	5x43	Shared	13.99	14.3529	Yes	Yes	No	No	6	5
185	5x41	6x59	Shared	6.14	5.26571	No	No	No	Yes	5	5
186	5x43	Lig	Shared	6.78	5.26571	No	No	Yes	Yes	5	0
187	5x47	5x48	Shared	9.28	8.84	No	Yes	No	No	8	5
188	5x47	5x51	Shared	7.31	4.34857	No	Yes	No	No	8	7
189	5x47	6x52	Shared	37.51	33.0686	No	Yes	Yes	Yes	8	7
190	5x51	6x45	Shared	4.42	4	No	No	No	No	7	7
191	5x54	6x41	Shared	10.11	10.3157	No	No	No	No	8	8
192	5x58	5x61	Shared	6.31	9.73571	Yes	Yes	No	No	9	8
193	5x58	5x62	Shared	10.32	7.95714	Yes	Yes	No	No	9	6
194	5x58	6x37	Shared	5.86	4.69	Yes	Yes	No	No	9	8
195	5x58	6x38	Shared	5.79	3.31429	Yes	Yes	No	No	9	6
196	5x58	6x41	Shared	10.78	12.4857	Yes	Yes	No	No	9	8
197	5x60	5x64	Shared	11.63	4.48714	No	Yes	Yes	Yes	5	5
198	5x62	6x26	Shared	5.36	5.66714	No	No	No	No	6	4
199	5x64	5x67	Shared	6.98	12.6271	Yes	Yes	No	No	5	4
200	5x64	5x68	Shared	6.37	5.46286	Yes	Yes	No	No	5	7
201	5x65	6x31	Shared	7.32	6.48143	No	No	Yes	Yes	8	5
202	5x66	6x25	Shared	5.75	5.54143	No	No	No	No	6	2
203	5x69	6x31	Shared	6.43	4.77714	No	No	Yes	Yes	5	5
204	6x26	6x35	Shared	21.09	15.4214	No	No	No	No	4	7
205	6x28	6x30	Shared	6.63	7.57429	No	No	No	No	5	7
206	6x28	6x31	Shared	7.71	9.36857	No	No	Yes	Yes	5	5
207	6x29	6x30	Shared	8.1	8.87143	No	No	No	No	6	7
208	6x35	7x55	Shared	11.14	5.12714	No	No	No	Yes	7	7
209	6x36	7x55	Shared	11.64	13.12	No	No	No	Yes	8	7
210	6x39	7x52	Shared	5.89	4.83714	No	No	No	No	7	8
211	6x40	7x49	Shared	4.25	10.1129	No	No	Yes	No	8	9
212	6x40	7x52	Shared	7.36	7.99	No	No	No	No	8	8
213	6x40	7x53	Shared	6.04	6.73143	No	No	Yes	Yes	8	9
214	6x44	6x48	Shared	12.03	11.8829	Yes	Yes	Yes	Yes	9	8
215	6x44	7x45	Shared	6.04	7.25	Yes	Yes	Yes	No	9	9
216	6x47	7x45	Shared	11.02	9.22429	No	Yes	Yes	No	9	9
217	6x48	6x52	Shared	6.01	5.3	Yes	Yes	Yes	Yes	8	7
218	6x48	7x41	Shared	12.67	12.67	Yes	Yes	No	No	8	7
219	6x49	6x53	Shared	7.14	6.73143	No	No	No	No	6	6
220	6x51	6x52	Shared	5.36	6.12429	Yes	Yes	Yes	Yes	6	7
221	6x51	7x34	Shared	10.32	11.6414	Yes	Yes	Yes	No	6	5
222	6x51	7x38	Shared	14.5	11.5629	Yes	Yes	Yes	No	6	5
223	6x51	Lig	Shared	6.42	8.38714	Yes	Yes	Yes	Yes	6	0
224	6x52	Lig	Shared	12.84	12.2943	Yes	Yes	Yes	Yes	7	0
225	6x54	7x37	Shared	4.47	3.83143	No	No	No	No	5	5
226	6x55	7x34	Shared	6.98	5.81286	No	No	Yes	No	5	5
227	6x58	E3.I303	Shared	17.23	5.30286	No	No	Yes	Yes	3	3
228	6x61	E3.N301	Shared	7.92	5.65714	No	No	No	No	2	2
229	7x38	7x42	Shared	11.63	13.2914	Yes	No	Yes	Yes	5	6
230	7x38	Lig	Shared	14.47	14.2714	Yes	No	Yes	Yes	5	0
231	7x39	7x42	Shared	17.36	14.7429	No	No	Yes	Yes	5	6
232	7x49	7x53	Shared	5.81	7.47429	Yes	No	Yes	Yes	9	9
233	7x53	8x50	Shared	4.13	4.71714	Yes	Yes	Yes	Yes	9	9
234	8x47	8x50	Shared	7.93	6.41714	No	No	Yes	Yes	8	9
235	8x48	8x51	Shared	4.32	6.17714	No	No	No	No	5	9
236	8x50	8x54	Shared	7.5	5.36	Yes	Yes	Yes	Yes	9	7
237	8x58	CT.L342	Shared	5.54	4.15286	No	No	No	No	6	8
238	3x49	I2x57	Shared	4.07	4.65286	Yes	Yes	No	No	8	7
239	1x49	7x50	Shared	4.06	4.06	No	No	No	No	8	9
240	3x47	5x58	Shared	4	3.43	No	No	Yes	Yes	8	9
241	5x44	6x52	Shared	3.96	3.77143	No	No	Yes	Yes	5	7
242	7x43	7x48	Shared	3.93	4.11714	No	No	No	No	5	6
243	8x52	I1x49	Shared	3.76	2.50714	No	No	No	No	4	6
244	6x42	6x45	Shared	3.64	1.82	No	No	No	No	5	7
245	5x45	5x48	Shared	3.63	2.76286	No	No	No	No	4	5
246	3x56	I2x50	Shared	3.56	3.56	No	No	No	No	6	8
247	8x47	8x48	Shared	3.56	3.56	No	No	No	No	8	5
248	5x36	5x39	Shared	3.49	3.49	No	No	Yes	Yes	4	6
249	2x52	3x35	Shared	3.42	3.42	No	No	No	No	7	7
250	1x54	2x47	Shared	3.25	3.25	No	No	No	No	7	9
251	2x551	3x31	Shared	3.25	1.62286	No	No	No	No	4	4
252	2x53	3x35	Shared	3.24	4.39714	No	Yes	No	No	7	7
253	5x36	5x38	Shared	3.13	1.78429	No	No	No	No	4	4
254	1x42	7x43	Shared	3.07	3.29286	No	No	No	No	6	5
255	3x45	4x45	Shared	3.07	3.07	No	No	No	No	7	6
256	6x54	E3.I303	Shared	3.07	4.38571	No	No	Yes	Yes	5	3
257	E2.C190	E2.E187	Shared	3.04	3.04	No	No	No	No	3	4
258	4x38	4x41	Shared	3	8.15143	No	No	No	No	8	5
259	E2.A176	E2.H178	Shared	2.93	2.93	No	No	No	Yes	1	2
260	1x37	1x41	Shared	2.85	1.83429	No	No	No	No	5	5
261	7x36	7x40	Shared	2.85	0.408571	No	No	No	No	5	7
262	4x41	I2x57	Shared	2.82	4.83429	No	No	No	No	5	7
263	3x21	E1x50	Shared	2.81	2.81	No	No	Yes	Yes	7	7
264	7x54	8x54	Shared	2.79	2.79	No	No	Yes	Yes	7	7
265	1x52	8x58	Shared	2.77	4.35	No	No	No	No	6	6
266	1x56	8x54	Shared	2.77	2.17857	No	No	Yes	Yes	8	7
267	2x62	E1x52	Shared	2.77	2.77	No	No	Yes	Yes	4	5
268	E2.I182	E2.Q179	Shared	2.74	1.76286	No	No	No	No	1	3
269	6x25	6x26	Shared	2.48	4.07571	No	No	No	No	2	4
270	1x60	8x57	Shared	2.44	3.82714	No	Yes	No	No	6	6
271	3x52	I2x56	Shared	2.44	2.61143	No	No	No	No	5	4
272	5x48	6x56	Shared	2.42	5.35286	No	No	No	No	5	6
273	8x49	I1x49	Shared	2.38	9.02	No	No	No	No	7	6
274	2x41	I1x51	Shared	2.25	3.70286	No	No	No	No	4	8
275	1x36	2x65	Shared	1.71	3.17571	No	No	No	No	5	6
276	5x40	6x59	Shared	1.7	1.7	No	No	No	Yes	5	5
277	4x59	4x60	Shared	1.64	1.87429	No	No	No	No	5	5
278	6x47	7x40	Shared	1.64	1.87286	No	Yes	No	No	9	7
279	6x50	7x37	Shared	1.64	2.58	No	No	No	No	9	5
280	1x33	1x37	Shared	1.54	2.19571	No	No	No	No	5	5
281	1x38	1x42	Shared	1.54	1.1	No	No	No	No	5	6
282	1x35	1x39	Shared	1.44	1.44286	No	No	Yes	Yes	5	6
283	4x47	4x51	Shared	1.43	1.63	No	No	No	No	3	4
284	4x51	4x55	Shared	1.43	0.612857	No	No	No	No	4	4
285	8x55	CT.L342	Shared	1.33	2.47	No	No	No	No	4	8
286	3x56	I2x51	Shared	1.32	5.09429	No	No	No	No	6	6
287	1x31	1x35	beta2_off	0	7.14714	No	Yes	No	No	3	5
288	1x46	2x54	beta2_off	0	4.03286	No	No	No	No	8	7
289	1x57	8x50	beta2_off	0	5.02	No	No	Yes	Yes	7	9
290	2x45	4x50	beta2_off	0	5.82571	No	No	No	Yes	9	9
291	2x53	7x42	beta2_off	0	4.27571	No	Yes	Yes	Yes	7	6
292	2x56	7x42	beta2_off	0	3.97	No	No	Yes	Yes	7	6
293	3x24	3x27	beta2_off	0	8.01857	Yes	Yes	No	Yes	5	5
294	3x26	E2.Y174	beta2_off	0	5.13	No	No	Yes	Yes	5	5
295	3x26	E2.R175	beta2_off	0	4.15714	No	No	No	Yes	5	2
296	3x27	4x58	beta2_off	0	9.64714	No	Yes	No	No	5	4
297	3x30	4x62	beta2_off	0	4.12571	No	No	No	No	6	4
298	3x39	6x44	beta2_off	0	4.14857	No	No	Yes	Yes	9	9
299	3x41	5x50	beta2_off	0	21.6171	No	No	No	Yes	5	8
300	3x44	5x50	beta2_off	0	3.77	No	No	No	Yes	7	8
301	I2x55	I2x57	beta2_off	0	4.5	No	No	No	No	4	7
302	4x60	E2.W173	beta2_off	0	4.43571	No	No	No	No	5	4
303	E2.Y174	E2.Y185	beta2_off	0	5.81429	Yes	Yes	No	No	5	1
304	E2.Y174	E2x52	beta2_off	0	3.98	Yes	Yes	Yes	Yes	5	4
305	E2.E180	E2.H178	beta2_off	0	4.39571	No	No	No	Yes	3	2
306	E2.C184	E2.F194	beta2_off	0	5.59	No	No	Yes	Yes	1	1
307	5x461	Lig	beta2_off	0	3.73143	No	No	Yes	Yes	5	0
308	5x58	6x34	beta2_off	0	4.35571	Yes	Yes	No	No	9	7
309	5x60	5x63	beta2_off	0	4.83857	No	Yes	No	No	5	3
310	6x39	7x55	beta2_off	0	6.08143	No	No	No	Yes	7	7
311	6x48	6x51	beta2_off	0	5.15143	Yes	Yes	Yes	Yes	8	6
312	6x48	Lig	beta2_off	0	3.82143	Yes	Yes	Yes	Yes	8	0
313	6x55	Lig	beta2_off	0	9.05857	No	No	Yes	Yes	5	0
314	7x30	7x32	beta2_off	0	10.4686	No	No	No	No	4	2
315	7x42	Lig	beta2_off	0	5.23429	Yes	Yes	Yes	Yes	6	0
316	6x61	E3.L302	beta2_off	0	3.61143	No	No	No	No	2	1
317	8x47	8x49	beta2_off	0	3.57429	No	No	No	No	8	7
318	1x53	7x50	beta2_off	0	3.53	No	No	No	No	9	9
319	5x49	5x50	beta2_off	0	3.53	No	No	No	Yes	5	8
320	2x38	4x42	beta2_off	0	3.39143	No	No	No	No	6	7
321	1x28	1x30	beta2_off	0	3.33714	No	No	No	No	0	2
322	7x31	7x32	beta2_off	0	3.27857	No	No	No	No	2	2
323	3x44	5x53	beta2_off	0	3.27	No	No	No	No	7	6
324	1x60	I1x50	beta2_off	0	3.13286	No	Yes	No	No	6	8
325	6x43	7x45	beta2_off	0	3.13143	No	No	Yes	No	6	9
326	7x33	E3.I303	beta2_off	0	3.07143	No	No	Yes	Yes	4	3
327	6x58	E3.D300	beta2_off	0	3.06143	No	No	No	No	3	1
328	5x56	5x60	beta2_off	0	3.05429	No	No	No	Yes	4	5
329	1x43	2x57	beta2_off	0	2.98	No	No	No	No	6	7
330	3x47	5x57	beta2_off	0	2.90714	No	No	No	No	8	6
331	1x59	1x60	beta2_off	0	2.83571	No	No	No	Yes	5	6
332	5x47	6x49	beta2_off	0	2.78571	No	Yes	No	No	8	6
333	1x46	7x47	beta2_off	0	2.77143	No	No	No	No	8	7
334	2x64	7x35	beta2_off	0	2.73	No	No	No	No	5	3
335	E3.I303	E3.L302	beta2_off	0	2.65143	Yes	Yes	No	No	3	1
336	3x48	3x52	beta2_off	0	2.62	No	No	No	No	6	5
337	2x49	4x50	beta2_off	0	2.59	No	No	No	Yes	8	9
338	6x47	7x48	beta2_off	0	2.39143	No	Yes	No	No	9	6
339	1x48	1x49	beta2_off	0	2.36571	No	No	No	No	4	8
340	6x57	E3.L302	beta2_off	0	2.34143	No	No	No	No	4	1
341	5x41	6x56	beta2_off	0	2.31286	No	No	No	No	5	6
342	1x27	1x31	beta2_off	0	2.28429	No	No	No	Yes	0	3
343	1x54	2x51	beta2_off	0	2.24143	No	No	Yes	No	7	7
344	3x34	4x54	beta2_off	0	2.19857	No	No	No	No	5	4
345	6x51	7x37	beta2_off	0	2.09143	Yes	Yes	No	No	6	5
346	I1x48	I1x49	beta2_off	0	1.99429	No	No	No	No	6	6
347	1x54	2x48	beta2_off	0	1.87143	No	No	No	No	7	6
348	1x58	1x59	beta2_off	0	1.83429	No	No	No	No	4	5
349	1x35	2x65	beta2_off	0	1.61571	No	No	No	No	5	6
350	3x45	4x49	beta2_off	0	1.6	No	No	No	No	7	7
351	5x54	5x55	beta2_off	0	1.52	No	No	No	No	8	5
352	1x31	2x67	beta2_off	0	1.49143	No	Yes	No	No	3	4
353	4x38	4x40	beta2_off	0	1.46	No	No	No	No	8	4
354	4x56	4x57	beta2_off	0	1.37143	No	No	No	No	5	7
355	1x28	1x31	beta2_off	0	0.958571	No	No	No	Yes	0	3
356	4x48	4x52	beta2_off	0	0.868571	No	No	No	No	4	4
357	4x44	4x48	beta2_off	0	0.868571	No	No	No	No	4	4
358	1x29	1x33	beta2_off	0	0.815714	No	No	No	No	0	5
359	3x41	4x52	beta2_off	0	0.814286	No	No	No	No	5	4
360	1x34	1x37	beta2_off	0	0.754286	No	No	No	No	5	5
361	1x44	1x48	beta2_off	0	0.695714	No	No	No	No	5	4
362	6x59	6x60	beta2_off	0	0.66	No	Yes	No	No	5	4
363	1x32	1x33	beta2_off	0	0.457143	Yes	No	No	No	4	5
364	E2.E187	E2.N183	beta2_off	0	0.374286	No	No	No	No	4	3
365	6x46	6x47	beta2_off	0	0.227143	No	No	No	Yes	5	9
366	4x56	5x46	beta2_off	0	0.227143	No	No	No	No	5	4
367	5x59	5x63	beta2_off	0	0.205714	No	No	No	No	3	3
368	6x32	7x55	beta2_off	0	0.177143	No	No	No	Yes	7	7
369	7x48	7x51	beta2_off	0	0.174286	No	No	No	No	6	6

Orange: nodes, hubs and links specific of beta2_off_allo network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of beta2_off network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	beta2_off_allo Avg Int. Strength	beta2_off Avg Int. Strength	beta2_off_allo Num Of Links	beta2_off Num Of Links	ConSurf
1	1x32	beta2_off_allo	3.0525	1.50571	4	2	4
2	1x50	beta2_off_allo	4.765	6.34048	4	3	9
3	2x40	beta2_off_allo	6.9525	6.90429	4	3	9
4	2x51	beta2_off_allo	4.6525	3.3981	4	3	7
5	3x43	beta2_off_allo	4.375	5.70357	4	2	8
6	3x50	beta2_off_allo	5.4	5.57048	4	3	9
7	E2x51	beta2_off_allo	6.98	5.47857	4	3	3
8	E2.T195	beta2_off_allo	5.7875	6.74357	4	2	3
9	7x34	beta2_off_allo	7.4725	8.72714	4	2	5
10	7x38	beta2_off_allo	11.28	13.0419	4	3	5
11	7x45	beta2_off_allo	6.3	6.53524	4	3	9
12	7x49	beta2_off_allo	5.57	8.79357	4	2	9
13	Alloh345	beta2_off_allo	11.2314	0	7	0	0
14	1x39	Shared	5.5675	5.46571	4	4	6
15	2x42	Shared	5.796	4.895	5	4	8
16	E1x50	Shared	9.57286	9.17041	7	7	7
17	E1x52	Shared	7.962	8.282	5	5	5
18	3x24	Shared	9.3425	7.97029	4	5	5
19	3x28	Shared	6.75	6.42214	5	4	5
20	3x49	Shared	6.805	6.01107	4	4	8
21	E2.Y174	Shared	10.1225	6.95762	4	6	5
22	E2x52	Shared	5.785	6.68179	4	4	4
23	E2.F194	Shared	5.6975	5.12886	4	5	1
24	5x39	Shared	8.274	6.83771	5	5	6
25	5x58	Shared	7.17667	6.56694	6	7	9
26	5x64	Shared	7.27	6.81607	4	4	5
27	6x31	Shared	7.815	6.94536	4	4	5
28	6x44	Shared	7.62	7.16514	4	5	9
29	6x48	Shared	8.66833	7.75524	6	6	8
30	6x51	Shared	9.736	7.4931	5	6	6
31	6x52	Shared	13.136	12.1117	5	5	7
32	E3.I303	Shared	8.4425	3.85286	4	4	3
33	7x42	Shared	11.3825	7.83449	4	7	6
34	7x53	Shared	7.36	7.29029	5	5	9
35	8x50	Shared	6.34	5.66452	5	6	9
36	8x54	Shared	6.9175	4.62679	4	4	7
37	Lig	Shared	9.96	8.90381	9	12	0
38	1x31	beta2_off	2.45	2.97036	1	4	3
39	1x60	beta2_off	4.60667	3.69657	3	5	6
40	2x53	beta2_off	5.15667	5.005	3	4	7
41	3x27	beta2_off	6.06	6.36714	3	4	5
42	4x50	beta2_off	7.305	5.77393	2	4	9
43	E2.R175	beta2_off	22.99	18.6068	3	4	2
44	E2.H178	beta2_off	5.30333	4.59036	3	4	2
45	5x47	beta2_off	18.0333	12.2607	3	4	8
46	5x50	beta2_off	11.855	8.98321	2	4	8
47	5x60	beta2_off	9.415	4.96929	2	4	5
48	6x47	beta2_off	6.33	3.42893	2	4	9
49	6x59	beta2_off	5	3.13464	3	4	5
50	7x55	beta2_off	11.39	6.12643	2	4	7

Orange: nodes, hubs and links specific of beta2_off_allo network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of beta2_off network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	beta2_off_allo Recurrence	beta2_off Recurrence	beta2_off_allo Hub1?	beta2_off Hub1?	beta2_off_allo Hub2?	beta2_off Hub2?	ConSurf1	ConSurf2
1	2x56	3x32	beta2_off_allo	19.3759	1.33595	No	No	No	No	7	7
2	2x53	2x56	beta2_off_allo	18.4609	1.00583	No	Yes	No	No	7	7
3	2x50	7x49	beta2_off_allo	16.6913	0	No	No	Yes	No	9	9
4	7x49	7x53	beta2_off_allo	49.3791	1.2431	Yes	No	Yes	Yes	9	9
5	1x52	8x54	beta2_off_allo	16.1805	6.01434	No	No	Yes	Yes	6	7
6	7x38	7x42	beta2_off_allo	11.6657	8.81003	Yes	No	Yes	Yes	5	6
7	6x48	7x38	beta2_off_allo	39.9356	0	Yes	Yes	Yes	No	8	5
8	3x43	6x44	beta2_off_allo	98.4725	2.92464	Yes	No	Yes	Yes	8	9
9	2x46	3x43	beta2_off_allo	49.2387	1.4649	No	No	Yes	No	9	8
10	2x46	7x49	beta2_off_allo	46.3119	0	No	No	Yes	No	9	9
11	3x43	6x41	beta2_off_allo	63.9836	0	Yes	No	No	No	8	8
12	5x58	6x41	beta2_off_allo	63.1218	4.53397	Yes	Yes	No	No	9	8
13	5x58	6x37	beta2_off_allo	28.3328	1.49069	Yes	Yes	No	No	9	8
14	3x46	6x37	beta2_off_allo	27.1829	0	No	No	No	No	9	8
15	2x42	3x46	beta2_off_allo	26.0306	1.305	Yes	Yes	No	No	8	9
16	3x32	Lig	beta2_off_allo	22.4769	1.66091	No	No	Yes	Yes	7	0
17	3x28	Lig	beta2_off_allo	36.2851	0	Yes	Yes	Yes	Yes	5	0
18	7x38	Lig	beta2_off_allo	35.8687	0.75824	Yes	No	Yes	Yes	5	0
19	3x28	E1x50	beta2_off_allo	16.8922	0.149585	Yes	Yes	Yes	Yes	5	7
20	E1x51	E1x52	beta2_off_allo	12.8882	4.45144	No	No	Yes	Yes	2	5
21	E2.T195	E2x52	beta2_off_allo	38.7349	1.38753	Yes	No	Yes	Yes	3	4
22	E2.T195	E2.Y174	beta2_off_allo	31.2692	0	Yes	No	Yes	Yes	3	5
23	E2.R175	E2.Y174	beta2_off_allo	59.4931	2.66674	No	Yes	Yes	Yes	2	5
24	4x64	E2.R175	beta2_off_allo	23.4985	1.45974	No	No	No	Yes	4	2
25	3x26	4x64	beta2_off_allo	20.8623	1.33079	No	No	No	No	5	4
26	3x26	4x62	beta2_off_allo	18.5989	0	No	No	No	No	5	4
27	3x27	4x62	beta2_off_allo	10.6563	0	No	Yes	No	No	5	4
28	5x39	E2.Y174	beta2_off_allo	30.6931	3.37855	Yes	Yes	Yes	Yes	6	5
29	3x36	Lig	beta2_off_allo	31.2765	1.33079	No	No	Yes	Yes	6	0
30	3x36	6x48	beta2_off_allo	31.2135	0.278537	No	No	Yes	Yes	6	8
31	5x50	Alloh345	beta2_off_allo	10.6587	0	No	Yes	Yes	No	8	0
32	E2.R175	E2.Y185	beta2_off_allo	33.9805	0.350751	No	Yes	No	No	2	1
33	6x48	6x52	beta2_off_allo	40.076	2.22314	Yes	Yes	Yes	Yes	8	7
34	1x39	7x39	Shared	10.068	22.3861	Yes	Yes	No	No	6	5
35	7x39	7x42	Shared	12.2637	26.5023	No	No	Yes	Yes	5	6
36	2x53	7x46	Shared	17.5022	99.0509	No	Yes	No	No	7	9
37	2x50	7x46	Shared	17.3037	96.7195	No	No	No	No	9	9
38	7x53	8x50	Shared	38.6356	37.2157	Yes	Yes	Yes	Yes	9	9
39	8x50	8x54	Shared	20.4217	10.4297	Yes	Yes	Yes	Yes	9	7
40	6x44	6x48	Shared	100	32.4289	Yes	Yes	Yes	Yes	9	8
41	2x42	3x49	Shared	18.1534	20.4622	Yes	Yes	Yes	Yes	8	8
42	E2x52	Lig	Shared	44.6005	62.0364	Yes	Yes	Yes	Yes	4	0
43	5x43	Lig	Shared	41.4195	12.3124	No	No	Yes	Yes	5	0
44	5x39	5x43	Shared	40.352	11.6212	Yes	Yes	No	No	6	5
45	3x33	Lig	Shared	15.7738	41.2544	No	No	Yes	Yes	5	0
46	3x33	4x57	Shared	14.44	40.1042	No	No	No	No	5	7
47	3x40	6x44	Shared	12.9802	12.854	No	No	Yes	Yes	7	9
48	3x40	5x50	Shared	11.8061	11.4664	No	No	No	Yes	7	8
49	5x58	5x61	Shared	27.5436	37.6386	Yes	Yes	No	No	9	8
50	3x54	5x61	Shared	26.3865	36.3697	No	No	No	No	9	8
51	3x54	5x64	Shared	25.2245	35.0905	No	No	Yes	Yes	9	5
52	5x60	5x64	Shared	11.1961	19.1726	No	Yes	Yes	Yes	5	5
53	5x64	5x68	Shared	12.0991	14.6645	Yes	Yes	No	No	5	7
54	5x68	I2x52	Shared	10.8984	13.2202	No	No	No	No	7	5
55	E2.A181	E2.Y185	Shared	31.3878	31.1549	No	No	No	No	4	1
56	E2.A181	E2.F194	Shared	23.4719	25.806	No	No	Yes	Yes	4	1
57	E2.F194	E2x51	Shared	18.2406	13.7205	Yes	Yes	Yes	No	1	3
58	6x52	Lig	Shared	37.1904	18.9766	Yes	Yes	Yes	Yes	7	0
59	5x47	6x52	Shared	11.9393	19.7091	No	Yes	Yes	Yes	8	7
60	1x35	1x39	beta2_off	8.00068	20.034	No	No	Yes	Yes	5	6
61	2x53	7x42	beta2_off	0	99.6802	No	Yes	Yes	Yes	7	6
62	1x50	2x50	beta2_off	7.64724	96.1108	Yes	No	No	No	9	9
63	1x50	2x47	beta2_off	1.56624	10.538	Yes	No	No	No	9	9
64	1x50	7x50	beta2_off	2.34332	90.8702	Yes	No	No	No	9	9
65	1x53	7x50	beta2_off	0	88.0023	No	No	No	No	9	9
66	1x53	7x53	beta2_off	1.35564	87.1924	No	No	Yes	Yes	9	9
67	8x50	I1x50	beta2_off	6.07858	11.6418	Yes	Yes	No	No	9	8
68	1x60	I1x50	beta2_off	0	10.1769	No	Yes	No	No	6	8
69	8x47	8x50	beta2_off	4.56559	10.538	No	No	Yes	Yes	8	9
70	7x42	Lig	beta2_off	0	100	Yes	Yes	Yes	Yes	6	0
71	3x34	4x57	beta2_off	4.26057	36.5915	No	No	No	No	5	7
72	3x34	4x50	beta2_off	2.84442	34.1982	No	No	No	Yes	5	9
73	2x45	4x50	beta2_off	0	30.5308	No	No	No	Yes	9	9
74	2x45	4x46	beta2_off	2.52003	28.0342	No	No	No	No	9	8
75	2x42	4x46	beta2_off	3.774	26.7705	Yes	Yes	No	No	8	8
76	3x49	I2x57	beta2_off	3.774	11.3323	Yes	Yes	No	No	8	7
77	4x41	I2x57	beta2_off	2.52003	10.0583	No	No	No	No	5	7
78	6x48	Lig	beta2_off	0	30.7061	Yes	Yes	Yes	Yes	8	0
79	E2.Y174	E2x52	beta2_off	0	59.8442	Yes	Yes	Yes	Yes	5	4
80	4x61	E2.Y174	beta2_off	0.343751	32.0524	No	No	Yes	Yes	5	5
81	3x30	4x61	beta2_off	2.79116	30.8093	No	No	No	No	6	5
82	3x30	4x58	beta2_off	1.40163	28.4211	No	No	No	No	6	4
83	3x27	4x58	beta2_off	0	27.1316	No	Yes	No	No	5	4
84	3x24	3x27	beta2_off	0	21.9477	Yes	Yes	No	Yes	5	5
85	6x40	7x53	beta2_off	0.229974	60.0763	No	No	Yes	Yes	8	9
86	6x40	7x52	beta2_off	3.06229	59.2975	No	No	No	No	8	8
87	6x39	7x52	beta2_off	1.53235	58.2246	No	No	No	No	7	8
88	6x39	7x55	beta2_off	0	57.1104	No	No	No	Yes	7	7
89	6x35	7x55	beta2_off	2.39173	53.964	No	No	No	Yes	7	7
90	6x26	6x35	beta2_off	3.64812	53.0355	No	No	No	No	4	7
91	5x62	6x26	beta2_off	7.23329	49.5693	No	No	No	No	6	4
92	5x58	5x62	beta2_off	8.47031	48.5944	Yes	Yes	No	No	9	6
93	3x51	5x60	beta2_off	9.97119	13.4575	No	No	No	Yes	8	5
94	3x51	3x52	beta2_off	7.50684	10.538	No	No	No	No	8	5
95	I2x52	I2x53	beta2_off	9.67344	11.7656	No	No	No	No	5	7
96	4x60	5x39	beta2_off	6.95732	10.1408	No	No	Yes	Yes	5	6
97	E2.Y174	E2.Y185	beta2_off	0	31.8822	Yes	Yes	No	No	5	1
98	E2.C190	E2.E187	beta2_off	5.33782	14.0249	No	No	No	No	3	4
99	5x47	5x48	beta2_off	5.80503	11.5077	No	Yes	No	No	8	5
100	6x44	7x45	beta2_off	2.8081	15.5981	Yes	Yes	Yes	No	9	9
101	6x47	7x45	beta2_off	3.80305	12.854	No	Yes	Yes	No	9	9
102	6x51	Lig	beta2_off	1.76717	15.1906	Yes	Yes	Yes	Yes	6	0
103	6x51	7x37	beta2_off	0	22.577	Yes	Yes	No	No	6	5
104	6x54	7x37	beta2_off	1.80106	18.564	No	No	No	No	5	5
105	6x54	E3.I303	beta2_off	2.83473	16.542	No	No	Yes	Yes	5	3
106	1x35	2x65	beta2_off	0	11.7862	No	No	No	No	5	6

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
2x53	2x56	Shared	5.65286	4.56	1	0	2	2
2x53	7x42	beta2_off	4.27571	0	1	0	2	1
2x56	3x32	Shared	6.88286	7.3	1	0	2	1
2x56	7x42	beta2_off	3.97	0	1	0	2	1
2x57	7x42	Shared	3.96857	5.05	0	0	2	1
2x59	3x24	Shared	18.0386	22.05	3	1	2	2
2x59	3x28	Shared	5.86857	5.01	3	1	2	1
3x24	E1x50	Shared	4.68571	5.62	3	1	2	2
3x28	E1x50	Shared	11.2471	14.99	3	1	1	2
3x24	3x28	Shared	4.95571	4.69	3	1	2	1
3x29	E2x52	Shared	5.74571	5.19	0	0	2	1
3x32	7x42	Shared	9.35857	11.49	1	0	1	1
3x32	Lig	Shared	18.62	20.43	1	0	1	0
3x33	4x57	Shared	5.99857	6.46	0	0	1	2
3x33	Lig	Shared	10.7643	10.09	0	0	1	0
3x36	6x48	Shared	7.70571	12.26	1	0	1	1
3x36	Lig	Shared	6.17571	7.85	1	0	1	0
3x37	5x461	Shared	8.90571	7.99	0	0	2	1
E2.Y174	E2x52	beta2_off	3.98	0	2	7	2	1
5x39	E2.Y174	Shared	6.66714	6.95	0	7	2	2
E2.T195	E2x52	Shared	7.78	6.49	0	7	2	1
E2x52	Lig	Shared	9.22143	7.33	0	0	1	0
5x39	E2.T195	Shared	5.70714	9.99	0	7	2	2
5x39	5x43	Shared	14.3529	13.99	0	7	2	1
5x43	Lig	Shared	5.26571	6.78	0	0	1	0
5x44	6x52	Shared	3.77143	3.96	0	0	2	1
5x461	Lig	beta2_off	3.73143	0	0	0	1	0
5x47	6x52	Shared	33.0686	37.51	0	0	2	1
6x44	6x48	Shared	11.8829	12.03	0	1	2	1
6x44	7x45	Shared	7.25	6.04	0	1	2	2
6x48	6x51	beta2_off	5.15143	0	1	1	1	1
6x48	6x52	Shared	5.3	6.01	1	1	1	1
6x48	7x41	Shared	12.67	12.67	1	1	1	2
6x48	Lig	beta2_off	3.82143	0	1	1	1	0
6x51	6x52	Shared	6.12429	5.36	1	1	1	1
6x51	7x34	Shared	11.6414	10.32	1	1	1	2
6x51	7x38	Shared	11.5629	14.5	1	1	1	1
6x51	Lig	Shared	8.38714	6.42	1	1	1	0
6x52	Lig	Shared	12.2943	12.84	1	1	1	0
6x55	7x34	Shared	5.81286	6.98	0	1	1	2
6x55	Lig	beta2_off	9.05857	0	0	1	1	0
7x38	7x42	Shared	13.2914	11.63	1	1	1	1
7x38	Lig	Shared	14.2714	14.47	1	1	1	0
7x39	7x42	Shared	14.7429	17.36	1	3	2	1
7x42	Lig	beta2_off	5.23429	0	1	0	1	0
2x60	3x28	Shared	3.61714	5.63	0	0	2	1
6x51	7x37	beta2_off	2.09143	0	1	1	1	2
4x56	4x57	beta2_off	1.37143	0	0	0	2	2
3x37	4x57	beta2_off_allo	0	4.8	0	0	2	2
E2.T195	E2.Y174	beta2_off_allo	0	4.99	0	7	2	2
7x34	E2x52	beta2_off_allo	0	4.13	0	1	2	1
6x48	7x38	beta2_off_allo	0	4.52	1	1	1	1
6x48	7x45	beta2_off_allo	0	4.52	1	1	1	2
6x51	6x55	beta2_off_allo	0	12.08	1	1	1	1
3x28	Lig	beta2_off_allo	0	3.43	3	1	1	0
4x56	5x461	beta2_off_allo	0	3.2	0	0	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	beta2_off_allo	6OBA-β₂-(S)-Alprenolol-GTPL11074
	beta2_off	6PS2-β₂-(S)-Alprenolol 6PS3-β₂-(S)-Carvedilol 6PS5-β₂-(S)-Propranolol 6PS6-β₂-Timolol 2RH1-β₂-(S)-Carazolol 6PS4-β₂-ICI 118-551 3NY9-β₂-PubChem 913103

Network Difference
Value	beta2_off_allo	beta2_off
I_min	4.09	3.71286
Number of Linked Nodes	260	275
Number of Specific Nodes	1 (0.38%)	16 (5.82%)
Number of Shared Nodes	259 (99.62%)	259 (94.18%)
Number of Links	286	302
Number of Specific Links	67 (23.43%)	83 (27.48%)
Number of Shared Links	219 (76.57%)	219 (72.52%)
Number of Hubs	37	37
Number of Specific Hubs	13 (35.14%)	13 (35.14%)
Number of Shared Hubs	24 (64.86%)	24 (64.86%)
Average % Shared Neighbours (Jaccard)	62.40
Average % Shared Neighbours (Otsuka)	69.56
Average % Shared Neighbours (Overlap Coefficient)	77.36
Average % Shared Cliques (k3-6)	58.06
Graphlets Similarity	0.618293

Paths Difference
Value	beta2_off_allo	beta2_off
Number Of Nodes in MetaPath	57	75
Specific Nodes in MetaPath	21 (36.84%)	39 (52.00%)
Shared Nodes in MetaPath	259 (99.62%)	259 (99.62%)
Number Of Links MetaPath	59	73
Specific Links in MetaPath	33 (55.93%)	47 (64.38%)
Shared Links in MetaPath	219 (76.57%)	219 (76.57%)
Number of Shortest Paths	76502	41422
Length Of Smallest Path	3	3
Average Path Length	13.992	15.5598
Length of Longest Path	28	42
Minimum Path Strength	1.43	0.636429
Average Path Strength	8.15568	6.60888
Maximum Path Strength	26.255	28.08
Minimum Path Correlation	0.7	0.701429
Average Path Correlation	0.918562	0.922852
Maximum Path Correlation	0.99	0.99
Minimum % Of Corr. Nodes	4.34783	2.7027
Average % Of Corr. Nodes	43.0226	44.1547
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	50.0054	38.7123
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download beta2_off_ortoallo.zip<

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