psnGPCR

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Orange: nodes, hubs and links specific of beta_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of beta_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	beta_off Int. Strength	beta_on Int. Strength	beta_off Hub1?	beta_on Hub1?	beta_off Hub2?	beta_on Hub2?	ConSurf1	ConSurf2
1	1x53	7x53	beta_off	100	0	No	No	Yes	Yes	9	9
2	8x49	I1x49	beta_off	100	0	No	No	No	No	6	5
3	2x39	3x50	beta_off	100	0	No	No	Yes	No	8	9
4	2x43	7x53	beta_off	100	0	No	No	Yes	Yes	7	9
5	2x53	2x56	beta_off	100	0	No	No	No	No	8	7
6	2x59	E1x52	beta_off	100	0	Yes	No	Yes	Yes	4	5
7	2x59	3x24	beta_off	100	0	Yes	No	No	No	4	4
8	2x66	E1x51	beta_off	100	0	No	No	No	No	4	4
9	3x24	3x27	beta_off	100	0	No	No	Yes	No	4	4
10	3x26	4x62	beta_off	100	0	No	No	No	No	6	4
11	3x26	E2	beta_off	100	0	No	No	Yes	Yes	6	3
12	3x29	E2x52	beta_off	100	0	No	No	Yes	No	6	4
13	3x30	4x62	beta_off	100	0	No	No	No	No	6	4
14	3x34	4x50	beta_off	100	0	No	No	Yes	No	5	9
15	3x39	6x44	beta_off	100	0	No	No	Yes	Yes	9	9
16	3x41	4x53	beta_off	100	0	Yes	No	No	No	6	8
17	3x43	6x44	beta_off	100	0	No	No	Yes	Yes	8	9
18	3x49	3x50	beta_off	100	0	Yes	No	Yes	No	9	9
19	3x50	3x53	beta_off	100	0	Yes	No	No	No	9	8
20	3x54	5x68	beta_off	100	0	No	No	Yes	No	9	7
21	3x55	5x64	beta_off	100	0	No	No	No	No	7	6
22	4x60	E2	beta_off	100	0	No	No	Yes	Yes	7	3
23	5x39	E2x52	beta_off	100	0	Yes	No	Yes	No	7	4
24	5x37	E3	beta_off	100	0	No	No	Yes	Yes	5	4
25	5x41	6x59	beta_off	100	0	No	No	Yes	No	5	5
26	5x51	6x45	beta_off	100	0	No	No	No	No	6	5
27	5x65	6x31	beta_off	100	0	No	No	Yes	No	8	5
28	6x35	7x55	beta_off	100	0	No	No	No	No	7	7
29	6x40	7x49	beta_off	100	0	No	No	No	Yes	8	9
30	6x40	7x52	beta_off	100	0	No	No	No	Yes	8	8
31	6x44	6x48	beta_off	100	0	Yes	Yes	Yes	Yes	9	8
32	6x44	7x45	beta_off	100	0	Yes	Yes	No	No	9	9
33	6x48	Lig	beta_off	100	0	Yes	Yes	Yes	Yes	8	0
34	6x54	7x37	beta_off	100	0	No	No	No	No	4	5
35	7x30	7x33	beta_off	100	0	No	No	Yes	No	5	4
36	7x49	7x53	beta_off	100	0	No	Yes	Yes	Yes	9	9
37	7x53	8x50	beta_off	100	0	Yes	Yes	Yes	Yes	9	8
38	8x48	8x51	beta_off	100	0	No	No	No	No	6	8
39	2x41	4x43	beta_off	100	0	Yes	No	No	No	5	4
40	3x27	3x31	beta_off	100	0	Yes	No	No	No	4	5
41	6x30	I2x53	beta_off	100	0	No	No	Yes	Yes	7	7
42	5x71	5x74	beta_off	100	0	No	No	No	No	0	0
43	6x29	6x30	beta_off	100	0	No	No	No	No	6	7
44	6x28	6x31	beta_off	100	0	No	No	Yes	No	0	5
45	2x38	I2x55	beta_off	100	0	No	No	No	No	6	5
46	3x49	I2x55	beta_off	100	0	Yes	No	No	No	9	5
47	I2x52	I2x53	beta_off	100	0	No	No	Yes	Yes	5	7
48	5x68	I2x52	beta_off	100	0	Yes	No	No	No	7	5
49	6x31	I2x53	beta_off	100	0	Yes	No	Yes	Yes	5	7
50	5x58	5x61	beta_off	100	0	No	Yes	No	No	9	9
51	5x58	5x62	beta_off	100	0	No	Yes	No	Yes	9	6
52	6x26	6x35	beta_off	100	0	No	No	No	No	0	7
53	5x36	5x39	beta_off	64.2857	0	No	No	Yes	No	5	7
54	1x47	2x51	beta_off	78.5714	0	No	No	No	No	6	7
55	3x46	6x37	beta_off	64.2857	0	No	No	No	No	9	8
56	3x50	6x34	beta_off	78.5714	0	Yes	No	No	No	9	7
57	E2	E3	beta_off	50	0	Yes	Yes	Yes	Yes	3	4
58	3x45	4x45	beta_off	50	0	No	No	No	No	5	6
59	1x32	2x65	beta_off	57.1429	0	No	No	No	No	5	5
60	E1x49	E1x51	beta_off	66.6667	0	No	No	No	No	3	4
61	1x50	2x47	beta_off	38.0952	0	No	No	No	No	9	8
62	5x69	6x31	beta_off	75	0	No	No	Yes	No	5	5
63	8x49	I1x50	beta_off	50	0	No	No	No	No	6	8
64	7x54	8x54	beta_off	8.33333	0	No	No	Yes	No	6	7
65	8x58	CT	beta_off	66.6667	0	No	No	No	No	6	0
66	3x51	5x61	beta_off	50	0	No	Yes	No	No	8	9
67	7x31	E2x51	beta_off	50	0	No	No	No	No	3	5
68	6x47	7x40	beta_off	57.1429	0	No	No	No	No	8	7
69	3x47	5x57	beta_off	8.33333	0	No	No	No	No	8	6
70	1x32	2x66	beta_off	50	0	No	No	No	No	5	4
71	3x48	5x57	beta_off	8.33333	0	No	No	No	No	6	6
72	7x43	7x48	beta_off	50	0	No	No	No	No	4	6
73	4x41	I2x57	beta_off	58.3333	0	No	No	No	No	7	6
74	6x59	6x60	beta_off	50	0	Yes	No	No	No	5	5
75	1x35	1x39	beta_off	14.2857	0	No	No	No	Yes	4	6
76	3x47	6x41	beta_off	8.33333	0	No	No	Yes	No	8	8
77	3x56	I2x56	beta_off	50	0	Yes	No	No	No	6	5
78	3x23	3x27	beta_off	23.8095	0	No	No	Yes	No	2	4
79	7x35	7x39	beta_off	0	0	No	No	Yes	Yes	4	6
80	5x41	5x45	beta_off	0	0	No	No	No	No	5	4
81	5x66	6x25	beta_off	50	0	No	No	No	No	5	0
82	1x52	8x57	beta_off	14.2857	0	No	No	No	No	6	6
83	2x50	Na1	beta_off	50	0	Yes	Yes	No	No	9	0
84	5x68	6x27	beta_off	50	0	Yes	No	No	No	7	0
85	5x72	6x24	beta_off	50	0	No	No	No	No	0	0
86	8x55	CT	beta_off	15.4762	0	No	No	No	No	4	0
87	5x74	I3	beta_off	50	0	No	No	No	Yes	0	0
88	2x52	2x551	beta_off	8.33333	0	No	No	No	No	6	4
89	3x56	I2x51	beta_off	50	0	Yes	No	No	No	6	6
90	1x42	1x46	beta_off	0	0	No	No	Yes	No	6	7
91	1x54	2x51	beta_off	0	0	No	No	No	No	7	7
92	6x38	6x41	beta_off	8.33333	0	No	No	Yes	No	5	8
93	8x52	I1x49	beta_off	14.2857	0	No	No	No	No	4	5
94	6x24	6x28	beta_off	25	0	No	No	No	No	0	0
95	I2x51	I2x54	beta_off	14.2857	0	No	No	No	No	6	5
96	4x40	4x43	beta_off	28.5714	0	No	No	No	No	5	4
97	2x41	I1x51	beta_off	14.2857	0	Yes	No	No	No	5	7
98	2x41	4x46	beta_off	0	0	Yes	No	No	No	5	7
99	6x23	I3	beta_off	16.6667	0	No	No	No	Yes	0	0
100	6x21	6x22	beta_off	16.6667	0	No	No	No	No	0	0
101	1x37	1x41	beta_off	7.14286	0	No	No	No	No	4	4
102	6x20	6x22	beta_off	8.33333	0	No	No	No	No	0	0
103	5x68	6x20	beta_off	8.33333	0	Yes	No	No	No	7	0
104	5x73	6x24	beta_off	16.6667	0	No	No	No	No	0	0
105	6x21	I3	beta_off	8.33333	0	No	No	No	Yes	0	0
106	1x38	1x42	beta_off	0	0	No	No	No	No	5	6
107	1x33	1x34	beta_off	0	0	No	No	No	No	5	4
108	1x44	1x48	beta_off	7.14286	0	No	No	No	No	5	4
109	6x29	6x32	beta_off	8.33333	0	No	No	No	No	6	8
110	5x66	5x70	beta_off	16.6667	0	No	No	No	No	5	0
111	1x28	1x29	beta_off	7.14286	0	No	No	No	No	0	0
112	1x31	2x67	beta_off	7.14286	0	No	Yes	No	No	3	4
113	1x57	1x58	beta_off	0	0	Yes	No	No	No	7	2
114	1x26	1x29	beta_off	8.33333	0	No	No	No	No	0	0
115	1x25	1x28	beta_off	8.33333	0	No	No	No	No	0	0
116	1x38	1x41	beta_off	0	0	No	No	No	No	5	4
117	1x27	1x30	beta_off	0	0	No	No	No	No	0	2
118	1x28	1x30	beta_off	7.14286	0	No	No	No	No	0	2
119	8x55	8x60	beta_off	8.33333	0	No	No	No	No	4	7
120	7x33	7x36	beta_off	0	0	Yes	No	No	No	4	5
121	7x48	7x51	beta_off	0	0	No	No	No	No	6	6
122	1x36	1x40	beta_off	0	0	No	No	No	No	5	4
123	1x31	1x35	Shared	100	33.3333	No	Yes	No	No	3	4
124	1x39	2x61	Shared	100	72.2222	No	Yes	No	No	6	6
125	1x39	7x39	Shared	100	100	No	Yes	Yes	Yes	6	6
126	1x43	2x58	Shared	100	100	No	No	No	No	5	9
127	1x46	2x54	Shared	100	100	Yes	No	No	No	7	7
128	1x46	7x46	Shared	100	66.6667	Yes	No	No	No	7	9
129	1x47	2x55	Shared	100	11.1111	No	No	No	No	6	5
130	1x49	7x50	Shared	100	44.4444	No	No	No	No	8	9
131	1x50	2x50	Shared	100	100	No	No	Yes	Yes	9	9
132	1x50	7x50	Shared	100	100	No	No	No	No	9	9
133	1x52	8x54	Shared	100	100	No	No	Yes	No	6	7
134	1x57	2x40	Shared	100	100	Yes	No	No	Yes	7	9
135	1x57	2x44	Shared	100	100	Yes	No	No	No	7	5
136	1x57	8x50	Shared	100	100	Yes	No	Yes	Yes	7	8
137	1x60	I1x50	Shared	100	100	Yes	Yes	No	No	6	8
138	8x50	I1x50	Shared	100	100	Yes	Yes	No	No	8	8
139	2x37	2x40	Shared	100	100	No	No	No	Yes	7	9
140	2x40	8x50	Shared	100	100	No	Yes	Yes	Yes	9	8
141	2x41	4x39	Shared	100	100	Yes	No	No	No	5	3
142	2x42	3x45	Shared	100	100	Yes	Yes	No	No	8	5
143	2x42	3x46	Shared	100	100	Yes	Yes	No	No	8	9
144	2x42	3x49	Shared	100	100	Yes	Yes	Yes	No	8	9
145	2x42	4x46	Shared	100	100	Yes	Yes	No	No	8	7
146	2x45	3x42	Shared	100	100	No	No	No	No	9	8
147	2x45	4x46	Shared	100	100	No	No	No	No	9	7
148	2x45	4x50	Shared	100	100	No	No	Yes	No	9	9
149	2x46	3x43	Shared	100	100	No	Yes	No	No	9	8
150	2x50	7x46	Shared	100	100	Yes	Yes	No	No	9	9
151	2x50	7x49	Shared	100	100	Yes	Yes	No	Yes	9	9
152	2x53	3x35	Shared	100	100	No	No	No	No	8	6
153	2x53	7x46	Shared	100	100	No	No	No	No	8	9
154	2x56	3x32	Shared	100	100	No	No	No	No	7	7
155	2x56	7x42	Shared	100	100	No	No	Yes	Yes	7	7
156	2x57	7x42	Shared	100	100	No	No	Yes	Yes	7	7
157	2x59	E1x50	Shared	100	100	Yes	No	Yes	Yes	4	7
158	2x59	3x28	Shared	100	100	Yes	No	No	Yes	4	6
159	2x60	3x28	Shared	100	100	No	No	No	Yes	6	6
160	2x62	E1x52	Shared	100	33.3333	No	No	Yes	Yes	4	5
161	2x63	E1x50	Shared	100	50	No	No	Yes	Yes	5	7
162	2x64	7x39	Shared	100	33.3333	No	No	Yes	Yes	5	6
163	E1x50	E1x52	Shared	100	100	Yes	Yes	Yes	Yes	7	5
164	3x25	E1x50	Shared	100	100	No	No	Yes	Yes	9	7
165	3x28	E1x50	Shared	100	100	No	Yes	Yes	Yes	6	7
166	E1x50	E2x50	Shared	100	100	Yes	Yes	No	No	7	9
167	E1x51	E1x52	Shared	100	66.6667	No	No	Yes	Yes	4	5
168	3x22	E2	Shared	100	100	No	No	Yes	Yes	4	3
169	3x25	E2x50	Shared	100	100	No	No	No	No	9	9
170	3x26	4x64	Shared	100	100	No	No	No	No	6	5
171	3x27	4x58	Shared	100	33.3333	Yes	No	No	Yes	4	5
172	3x30	4x58	Shared	100	100	No	No	No	Yes	6	5
173	3x30	4x61	Shared	100	100	No	No	No	No	6	6
174	3x32	7x42	Shared	100	100	No	No	Yes	Yes	7	7
175	3x32	Lig	Shared	100	100	No	No	Yes	Yes	7	0
176	3x33	4x57	Shared	100	100	No	No	No	No	6	7
177	3x33	Lig	Shared	100	100	No	No	Yes	Yes	6	0
178	3x36	6x48	Shared	100	100	No	No	Yes	Yes	6	8
179	3x36	Lig	Shared	100	100	No	No	Yes	Yes	6	0
180	3x37	4x53	Shared	100	100	No	No	No	No	6	8
181	3x37	5x461	Shared	100	100	No	No	No	No	6	6
182	3x38	4x50	Shared	100	100	No	No	Yes	No	7	9
183	3x40	5x50	Shared	100	100	No	No	Yes	Yes	8	9
184	3x40	6x44	Shared	100	100	No	No	Yes	Yes	8	9
185	3x41	4x49	Shared	100	100	Yes	No	No	No	6	6
186	3x49	I2x53	Shared	100	100	Yes	No	Yes	Yes	9	7
187	3x51	3x55	Shared	100	100	No	Yes	No	No	8	7
188	3x51	5x60	Shared	100	100	No	Yes	No	Yes	8	5
189	3x53	I2x53	Shared	100	100	No	No	Yes	Yes	8	7
190	3x54	5x64	Shared	100	11.1111	No	No	No	No	9	6
191	I2x53	I2x57	Shared	100	100	Yes	Yes	No	No	7	6
192	4x38	4x41	Shared	100	100	No	No	No	No	8	7
193	4x61	E2	Shared	100	100	No	No	Yes	Yes	6	3
194	4x63	E2	Shared	100	100	No	No	Yes	Yes	5	3
195	4x64	E2	Shared	100	100	No	No	Yes	Yes	5	3
196	E2	E2	Shared	100	100	Yes	Yes	Yes	Yes	3	3
197	E2	E2x52	Shared	100	100	Yes	Yes	Yes	No	3	4
198	5x39	E2	Shared	100	100	Yes	No	Yes	Yes	7	3
199	E2	E2x51	Shared	100	100	Yes	Yes	No	No	3	5
200	E2x52	Lig	Shared	100	100	Yes	No	Yes	Yes	4	0
201	5x37	6x59	Shared	100	100	No	No	Yes	No	5	5
202	5x39	5x43	Shared	100	100	Yes	No	No	No	7	6
203	5x43	Lig	Shared	100	100	No	No	Yes	Yes	6	0
204	5x44	6x52	Shared	100	100	No	No	Yes	Yes	6	7
205	5x461	Lig	Shared	100	100	No	No	Yes	Yes	6	0
206	5x47	5x48	Shared	100	100	Yes	Yes	No	No	7	5
207	5x47	5x51	Shared	100	100	Yes	Yes	No	No	7	6
208	5x47	6x52	Shared	100	100	Yes	Yes	Yes	Yes	7	7
209	5x48	6x56	Shared	100	100	No	No	No	No	5	5
210	5x49	5x50	Shared	100	33.3333	No	No	Yes	Yes	5	9
211	5x54	6x41	Shared	100	100	No	No	Yes	No	8	8
212	5x56	5x60	Shared	100	50	No	No	No	Yes	5	5
213	5x58	6x41	Shared	100	100	No	Yes	Yes	No	9	8
214	5x64	5x67	Shared	100	11.1111	No	No	No	No	6	4
215	6x36	7x55	Shared	100	33.3333	No	No	No	No	8	7
216	6x39	7x52	Shared	100	33.3333	No	No	No	Yes	7	8
217	6x39	7x55	Shared	100	27.7778	No	No	No	No	7	7
218	6x40	7x53	Shared	100	100	No	No	Yes	Yes	8	9
219	6x47	7x45	Shared	100	100	No	No	No	No	8	9
220	6x48	6x51	Shared	100	100	Yes	Yes	Yes	Yes	8	7
221	6x48	6x52	Shared	100	100	Yes	Yes	Yes	Yes	8	7
222	6x48	7x41	Shared	100	100	Yes	Yes	No	No	8	6
223	6x49	6x53	Shared	100	100	No	Yes	No	No	7	6
224	6x50	7x37	Shared	100	100	No	No	No	No	9	5
225	6x51	6x52	Shared	100	100	Yes	Yes	Yes	Yes	7	7
226	6x51	7x34	Shared	100	100	Yes	Yes	No	No	7	4
227	6x51	7x38	Shared	100	100	Yes	Yes	No	No	7	6
228	6x51	Lig	Shared	100	100	Yes	Yes	Yes	Yes	7	0
229	6x52	Lig	Shared	100	100	Yes	Yes	Yes	Yes	7	0
230	6x54	E3	Shared	100	100	No	No	Yes	Yes	4	4
231	6x55	7x34	Shared	100	100	No	Yes	No	No	6	4
232	6x55	Lig	Shared	100	100	No	Yes	Yes	Yes	6	0
233	6x61	E3	Shared	100	100	No	No	Yes	Yes	4	4
234	7x30	7x32	Shared	100	100	No	No	No	No	5	3
235	7x32	7x33	Shared	100	33.3333	No	No	Yes	No	3	4
236	7x33	7x37	Shared	100	33.3333	Yes	No	No	No	4	5
237	7x38	7x42	Shared	100	100	No	No	Yes	Yes	6	7
238	7x38	Lig	Shared	100	100	No	No	Yes	Yes	6	0
239	7x39	7x42	Shared	100	100	Yes	Yes	Yes	Yes	6	7
240	7x42	Lig	Shared	100	100	Yes	Yes	Yes	Yes	7	0
241	8x47	8x50	Shared	100	100	No	No	Yes	Yes	8	8
242	8x50	8x54	Shared	100	100	Yes	Yes	Yes	No	8	7
243	1x60	8x56	Shared	100	100	Yes	Yes	No	No	6	4
244	3x34	4x57	Shared	100	100	No	No	No	No	5	7
245	3x41	5x50	Shared	100	100	Yes	No	Yes	Yes	6	9
246	5x60	5x63	Shared	100	33.3333	No	Yes	No	No	5	4
247	6x58	E3	Shared	100	100	No	No	Yes	Yes	4	4
248	3x44	5x53	Shared	57.1429	100	No	No	No	No	6	6
249	1x52	8x58	Shared	75	50	No	No	No	No	6	6
250	2x52	3x35	Shared	47.619	100	No	No	No	No	6	6
251	8x47	8x48	Shared	54.7619	100	No	No	No	No	8	6
252	3x41	4x52	Shared	57.1429	33.3333	Yes	No	No	No	6	4
253	1x51	2x51	Shared	38.0952	100	No	No	No	No	3	7
254	6x43	7x52	Shared	64.2857	100	No	No	No	Yes	6	8
255	1x54	2x47	Shared	8.33333	66.6667	No	No	No	No	7	8
256	1x55	8x57	Shared	58.3333	33.3333	No	No	No	No	4	6
257	2x57	2x58	Shared	64.2857	66.6667	No	No	No	No	7	9
258	6x57	E3	Shared	57.1429	33.3333	No	No	Yes	Yes	5	4
259	5x51	5x55	Shared	50	66.6667	No	No	No	No	6	5
260	1x60	8x53	Shared	50	44.4444	Yes	Yes	No	No	6	7
261	1x59	1x60	Shared	50	33.3333	No	No	Yes	Yes	5	6
262	3x21	E1x50	Shared	0	0	No	No	Yes	Yes	7	7
263	5x47	6x49	Shared	23.8095	100	Yes	Yes	No	Yes	7	7
264	1x36	2x65	Shared	25	16.6667	No	No	No	No	5	5
265	3x56	I2x50	Shared	21.4286	0	Yes	No	No	No	6	8
266	6x43	7x48	Shared	16.6667	44.4444	No	No	No	No	6	6
267	3x48	3x52	Shared	0	0	No	No	No	No	6	5
268	1x46	7x47	Shared	23.8095	100	Yes	No	No	No	7	6
269	2x42	4x42	Shared	8.33333	11.1111	Yes	Yes	No	No	8	7
270	2x49	4x50	Shared	0	0	No	No	Yes	No	8	9
271	I1x48	I1x51	Shared	25	100	No	No	No	No	6	7
272	5x62	5x66	Shared	50	100	No	Yes	No	No	6	5
273	3x44	5x50	Shared	50	44.4444	No	No	Yes	Yes	6	9
274	4x48	4x52	Shared	0	0	No	No	No	No	3	4
275	1x56	8x54	Shared	8.33333	0	No	No	Yes	No	7	7
276	1x48	1x49	Shared	14.2857	33.3333	No	No	No	No	4	8
277	4x56	5x46	Shared	50	100	No	No	No	No	5	4
278	6x42	6x45	Shared	16.6667	0	No	No	No	No	5	5
279	4x59	4x60	Shared	15.4762	50	No	No	No	No	6	7
280	5x40	6x59	Shared	8.33333	0	No	No	Yes	No	6	5
281	5x36	5x38	Shared	0	100	No	No	No	No	5	4
282	4x55	4x59	Shared	29.7619	16.6667	No	No	No	No	4	6
283	3x34	4x54	Shared	0	0	No	No	No	No	5	3
284	1x54	2x48	Shared	7.14286	33.3333	No	No	No	No	7	5
285	3x55	3x56	Shared	25	16.6667	No	No	Yes	No	7	6
286	1x45	7x47	Shared	8.33333	16.6667	No	No	No	No	5	6
287	3x37	4x56	Shared	0	55.5556	No	No	No	No	6	5
288	4x44	4x48	Shared	0	0	No	No	No	No	3	3
289	5x55	5x59	Shared	0	0	No	No	No	No	5	2
290	1x33	1x37	Shared	0	0	No	No	No	No	5	4
291	4x47	4x51	Shared	7.14286	0	No	No	No	No	4	4
292	4x51	4x55	Shared	0	0	No	No	No	No	4	4
293	1x29	1x32	Shared	8.33333	33.3333	No	No	No	No	0	5
294	1x53	2x47	beta_on	0	100	No	No	No	No	9	8
295	1x53	7x54	beta_on	0	100	No	No	No	No	9	6
296	2x40	I1x50	beta_on	0	100	No	Yes	No	No	9	8
297	2x39	3x49	beta_on	0	100	No	No	Yes	No	8	9
298	2x46	2x50	beta_on	0	100	No	Yes	Yes	Yes	9	9
299	2x46	3x42	beta_on	0	100	No	Yes	No	No	9	8
300	2x46	7x49	beta_on	0	100	No	Yes	No	Yes	9	9
301	2x50	3x39	beta_on	0	100	Yes	Yes	No	No	9	9
302	3x24	E1x52	beta_on	0	100	No	No	Yes	Yes	4	5
303	3x28	Lig	beta_on	0	100	No	Yes	Yes	Yes	6	0
304	3x34	4x58	beta_on	0	100	No	No	No	Yes	5	5
305	3x38	4x53	beta_on	0	100	No	No	No	No	7	8
306	3x40	6x48	beta_on	0	100	No	No	Yes	Yes	8	8
307	3x43	7x49	beta_on	0	100	No	No	No	Yes	8	9
308	3x43	7x53	beta_on	0	100	No	No	Yes	Yes	8	9
309	3x46	7x53	beta_on	0	100	No	No	Yes	Yes	9	9
310	3x47	5x58	beta_on	0	100	No	No	No	Yes	8	9
311	3x50	5x58	beta_on	0	100	Yes	No	No	Yes	9	9
312	3x50	7x53	beta_on	0	100	Yes	No	Yes	Yes	9	9
313	3x51	5x57	beta_on	0	100	No	Yes	No	No	8	6
314	3x56	I2x52	beta_on	0	100	Yes	No	No	No	6	5
315	4x57	4x58	beta_on	0	100	No	No	No	Yes	7	5
316	4x60	5x39	beta_on	0	100	No	No	Yes	No	7	7
317	5x36	E2	beta_on	0	100	No	No	Yes	Yes	5	3
318	5x37	6x60	beta_on	0	100	No	No	No	No	5	5
319	5x44	6x55	beta_on	0	100	No	No	No	Yes	6	6
320	5x47	6x44	beta_on	0	100	Yes	Yes	Yes	Yes	7	9
321	5x47	6x48	beta_on	0	100	Yes	Yes	Yes	Yes	7	8
322	5x51	6x44	beta_on	0	100	No	No	Yes	Yes	6	9
323	5x54	5x58	beta_on	0	100	No	No	No	Yes	8	9
324	5x54	6x44	beta_on	0	100	No	No	Yes	Yes	8	9
325	5x58	6x37	beta_on	0	100	No	Yes	No	No	9	8
326	5x58	6x40	beta_on	0	100	No	Yes	No	No	9	8
327	5x62	6x34	beta_on	0	100	No	Yes	No	No	6	7
328	5x62	6x37	beta_on	0	100	No	Yes	No	No	6	8
329	6x48	7x45	beta_on	0	100	Yes	Yes	No	No	8	9
330	6x51	6x55	beta_on	0	100	Yes	Yes	No	Yes	7	6
331	6x58	7x34	beta_on	0	100	No	No	No	No	4	4
332	E3	E3	beta_on	0	100	Yes	Yes	Yes	Yes	4	4
333	7x45	7x49	beta_on	0	100	No	No	No	Yes	9	9
334	7x52	7x53	beta_on	0	100	No	Yes	Yes	Yes	8	9
335	7x54	8x50	beta_on	0	100	No	No	Yes	Yes	6	8
336	8x47	8x49	beta_on	0	100	No	No	No	No	8	6
337	1x42	7x39	beta_on	0	100	No	No	Yes	Yes	6	6
338	I3	I3	beta_on	0	100	No	Yes	No	Yes	0	0
339	7x36	7x40	beta_on	0	33.3333	No	No	No	No	5	7
340	7x35	Lig	beta_on	0	66.6667	No	No	Yes	Yes	4	0
341	6x49	6x50	beta_on	0	66.6667	No	Yes	No	No	7	9
342	1x60	I1x49	beta_on	0	55.5556	Yes	Yes	No	No	6	5
343	5x69	6x29	beta_on	0	66.6667	No	No	No	No	5	6
344	6x45	6x49	beta_on	0	44.4444	No	No	No	Yes	5	7
345	4x39	4x43	beta_on	0	33.3333	No	No	No	No	3	4
346	5x60	5x64	beta_on	0	50	No	Yes	No	No	5	6
347	3x51	3x52	beta_on	0	44.4444	No	Yes	No	No	8	5
348	5x66	6x30	beta_on	0	33.3333	No	No	No	No	5	7
349	5x67	5x71	beta_on	0	33.3333	No	No	No	No	4	0
350	1x50	2x51	beta_on	0	33.3333	No	No	No	No	9	7
351	2x51	2x55	beta_on	0	33.3333	No	No	No	No	7	5
352	2x66	E1x49	beta_on	0	33.3333	No	No	No	No	4	3
353	2x37	2x39	beta_on	0	33.3333	No	No	No	No	7	8
354	3x28	3x29	beta_on	0	33.3333	No	Yes	No	No	6	6
355	8x51	8x55	beta_on	0	44.4444	No	No	No	No	8	4
356	5x37	5x41	beta_on	0	33.3333	No	No	No	No	5	5
357	3x54	5x61	beta_on	0	11.1111	No	No	No	No	9	9
358	E1x49	E2	beta_on	0	50	No	No	Yes	Yes	3	3
359	7x55	8x51	beta_on	0	50	No	No	No	No	7	8
360	2x52	3x31	beta_on	0	33.3333	No	No	No	No	6	5
361	2x40	2x43	beta_on	0	16.6667	No	Yes	No	No	9	7
362	5x40	E2	beta_on	0	33.3333	No	No	Yes	Yes	6	3
363	3x44	3x48	beta_on	0	0	No	No	No	No	6	6
364	2x551	3x31	beta_on	0	44.4444	No	No	No	No	4	5
365	4x58	4x62	beta_on	0	50	No	Yes	No	No	5	4
366	1x59	8x57	beta_on	0	27.7778	No	No	No	No	5	6
367	6x31	6x35	beta_on	0	44.4444	Yes	No	No	No	5	7
368	5x75	I3	beta_on	0	33.3333	No	No	No	Yes	0	0
369	1x35	2x65	beta_on	0	33.3333	No	No	No	No	4	5
370	2x38	I2x57	beta_on	0	16.6667	No	No	No	No	6	6
371	1x29	1x31	beta_on	0	33.3333	No	No	No	Yes	0	3
372	5x73	I3	beta_on	0	33.3333	No	No	No	Yes	0	0
373	5x74	5x75	beta_on	0	33.3333	No	No	No	No	0	0
374	5x45	5x49	beta_on	0	0	No	No	No	No	4	5
375	2x42	4x45	beta_on	0	0	Yes	Yes	No	No	8	6
376	7x36	7x37	beta_on	0	33.3333	No	No	No	No	5	5
377	7x31	Lig	beta_on	0	33.3333	No	No	Yes	Yes	3	0
378	1x42	7x43	beta_on	0	33.3333	No	No	No	No	6	4
379	5x68	5x71	beta_on	0	16.6667	Yes	No	No	No	7	0
380	6x31	6x34	beta_on	0	33.3333	Yes	No	No	No	5	7
381	8x52	8x55	beta_on	0	16.6667	No	No	No	No	4	4
382	I2x52	I2x56	beta_on	0	16.6667	No	No	No	No	5	5
383	2x38	4x39	beta_on	0	16.6667	No	No	No	No	6	3
384	6x27	6x30	beta_on	0	33.3333	No	No	No	No	0	7
385	I2x55	I2x56	beta_on	0	16.6667	No	No	No	No	5	5
386	5x69	5x73	beta_on	0	33.3333	No	No	No	No	5	0
387	I2x50	I2x51	beta_on	0	33.3333	No	No	No	No	8	6
388	I2x53	I2x54	beta_on	0	11.1111	Yes	Yes	No	No	7	5
389	1x60	I1x48	beta_on	0	33.3333	Yes	Yes	No	No	6	6
390	6x32	6x35	beta_on	0	27.7778	No	No	No	No	8	7
391	5x72	5x76	beta_on	0	0	No	No	No	No	0	0
392	5x72	6x29	beta_on	0	16.6667	No	No	No	No	0	6
393	5x70	5x71	beta_on	0	16.6667	No	No	No	No	0	0
394	1x38	7x39	beta_on	0	11.1111	No	No	Yes	Yes	5	6
395	1x36	1x39	beta_on	0	11.1111	No	No	No	Yes	5	6
396	4x38	4x40	beta_on	0	0	No	No	No	No	8	5
397	3x23	3x24	beta_on	0	11.1111	No	No	No	No	2	4
398	5x69	6x30	beta_on	0	16.6667	No	No	No	No	5	7
399	5x65	6x33	beta_on	0	0	No	No	No	No	8	8
400	7x51	7x52	beta_on	0	0	No	No	No	Yes	6	8
401	4x40	4x44	beta_on	0	11.1111	No	No	No	No	5	3
402	1x30	1x31	beta_on	0	16.6667	No	No	No	Yes	2	3
403	1x58	I1x51	beta_on	0	0	No	No	No	No	2	7
404	6x37	6x38	beta_on	0	0	No	No	No	No	8	5
405	2x67	E1x49	beta_on	0	0	No	No	No	No	4	3
406	5x62	6x33	beta_on	0	0	No	Yes	No	No	6	8
407	1x31	1x34	beta_on	0	0	No	Yes	No	No	3	4
408	1x44	1x47	beta_on	0	0	No	No	No	No	5	6
409	1x34	1x37	beta_on	0	0	No	No	No	No	4	4
410	8x58	8x59	beta_on	0	0	No	No	No	No	6	3
411	1x41	1x44	beta_on	0	0	No	No	No	No	4	5
412	6x46	6x47	beta_on	0	0	No	No	No	No	5	8
413	1x39	1x40	beta_on	0	0	No	Yes	No	No	6	4
414	4x56	5x42	beta_on	0	0	No	No	No	No	5	4
415	5x42	5x46	beta_on	0	0	No	No	No	No	4	4

Orange: nodes, hubs and links specific of beta_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of beta_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	beta_off Avg Int. Strength	beta_on Avg Int. Strength	beta_off Num Of Links	beta_on Num Of Links	ConSurf
1	1x46	beta_off	0	0	4	3	7
2	1x57	beta_off	0	0	4	3	7
3	2x41	beta_off	0	0	4	1	5
4	2x59	beta_off	0	0	4	2	4
5	3x27	beta_off	0	0	4	1	4
6	3x41	beta_off	33.3333	0	4	3	6
7	3x49	beta_off	61.9048	33.3333	4	3	9
8	3x50	beta_off	50	0	4	2	9
9	3x56	beta_off	0	0	4	3	6
10	4x50	beta_off	0	0	4	3	9
11	E2x52	beta_off	50	0	4	2	4
12	5x39	beta_off	41.6667	44.4444	4	3	7
13	5x68	beta_off	0	0	4	1	7
14	6x31	beta_off	21.4286	0	4	2	5
15	6x41	beta_off	0	0	4	2	8
16	6x59	beta_off	0	0	4	2	5
17	7x33	beta_off	0	0	4	2	4
18	8x54	beta_off	0	0	4	3	7
19	1x60	Shared	0	16.6667	4	6	6
20	2x42	Shared	78.5714	22.2222	5	6	8
21	2x50	Shared	8.33333	88.8889	4	5	9
22	E1x50	Shared	100	100	7	7	7
23	E1x52	Shared	85.7143	0	4	4	5
24	I2x53	Shared	50	0	6	4	7
25	E2	Shared	100	100	12	12	3
26	5x47	Shared	0	100	4	6	7
27	5x50	Shared	0	33.3333	4	4	9
28	6x44	Shared	100	38.8889	5	4	9
29	6x48	Shared	92.8571	100	6	7	8
30	6x51	Shared	92.8571	100	5	6	7
31	6x52	Shared	92.8571	100	5	5	7
32	E3	Shared	84.5238	100	6	6	4
33	7x39	Shared	41.6667	0	4	5	6
34	7x42	Shared	100	100	6	6	7
35	7x53	Shared	91.6667	38.8889	5	5	9
36	8x50	Shared	100	100	6	6	8
37	Lig	Shared	100	100	12	14	0
38	1x39	beta_on	0	0	3	4	6
39	2x40	beta_on	0	16.6667	3	5	9
40	2x46	beta_on	0	44.4444	1	4	9
41	3x28	beta_on	0	33.3333	3	5	6
42	3x51	beta_on	0	16.6667	3	4	8
43	4x58	beta_on	0	0	2	5	5
44	5x58	beta_on	50	100	3	6	9
45	5x60	beta_on	0	16.6667	3	4	5
46	5x62	beta_on	0	0	2	4	6
47	I3	beta_on	0	0	3	4	0
48	6x49	beta_on	0	0	2	4	7
49	6x55	beta_on	0	33.3333	2	4	6
50	7x49	beta_on	0	83.3333	3	4	9
51	7x52	beta_on	0	0	3	4	8
52	1x31	beta_on	0	0	2	4	3

Orange: nodes, hubs and links specific of beta_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of beta_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	beta_off Recurrence	beta_on Recurrence	beta_off Hub1?	beta_on Hub1?	beta_off Hub2?	beta_on Hub2?	ConSurf1	ConSurf2
1	2x56	7x42	beta_off	52.3255	2.2527	No	No	Yes	Yes	7	7
2	2x53	2x56	beta_off	100	0	No	No	No	No	8	7
3	1x46	7x46	beta_off	16.7896	9.18267	Yes	No	No	No	7	9
4	1x50	2x47	beta_off	11.8283	0	No	No	No	No	9	8
5	1x54	2x47	beta_off	10.1599	5.0064	No	No	No	No	7	8
6	7x49	7x53	beta_off	44.1881	0	No	Yes	Yes	Yes	9	9
7	7x53	8x50	beta_off	41.5231	0	Yes	Yes	Yes	Yes	9	8
8	1x52	8x54	beta_off	10.6418	6.99214	No	No	Yes	No	6	7
9	8x50	I1x50	beta_off	13.0987	0.639971	Yes	Yes	No	No	8	8
10	3x34	4x57	beta_off	73.1345	3.91662	No	No	No	No	5	7
11	3x34	4x50	beta_off	71.7107	0	No	No	Yes	No	5	9
12	6x48	Lig	beta_off	15.9317	0	Yes	Yes	Yes	Yes	8	0
13	6x44	6x48	beta_off	14.7379	0	Yes	Yes	Yes	Yes	9	8
14	4x61	E2	beta_off	32.7979	4.26038	No	No	Yes	Yes	6	3
15	3x30	4x61	beta_off	31.8889	2.50869	No	No	No	No	6	6
16	3x30	4x58	beta_off	31.2354	2.44286	No	No	No	Yes	6	5
17	3x27	4x58	beta_off	30.1438	1.84312	Yes	No	No	Yes	4	5
18	3x24	3x27	beta_off	26.902	0	No	No	Yes	No	4	4
19	2x59	3x24	beta_off	25.7995	0	Yes	No	No	No	4	4
20	2x59	E1x52	beta_off	16.6253	0	Yes	No	Yes	Yes	4	5
21	E1x51	E1x52	beta_off	14.6503	2.04059	No	No	Yes	Yes	4	5
22	2x66	E1x51	beta_off	12.2773	0	No	No	No	No	4	4
23	I2x52	I2x53	beta_off	38.8654	0	No	No	Yes	Yes	5	7
24	5x68	I2x52	beta_off	37.8103	0	Yes	No	No	No	7	5
25	3x54	5x68	beta_off	30.1621	0	No	No	Yes	No	9	7
26	3x54	5x64	beta_off	29.0997	4.22015	No	No	No	No	9	6
27	3x55	5x64	beta_off	26.8874	0	No	No	No	No	7	6
28	E2	E3	beta_off	20.1446	0	Yes	Yes	Yes	Yes	3	4
29	3x51	5x61	beta_off	15.3877	0	No	Yes	No	No	8	9
30	5x58	5x61	beta_off	14.1976	0	No	Yes	No	No	9	9
31	6x40	7x49	beta_off	16.8991	0	No	No	No	Yes	8	9
32	6x40	7x52	beta_off	16.4245	0	No	No	No	Yes	8	8
33	1x32	2x66	beta_off	11.058	0	No	No	No	No	5	4
34	1x42	1x46	beta_off	10.1599	0	No	No	Yes	No	6	7
35	2x56	3x32	beta_off	48.8646	1.95282	No	No	No	No	7	7
36	3x32	Lig	beta_off	49.3027	3.75571	No	No	Yes	Yes	7	0
37	2x53	7x46	Shared	95.1519	11.461	No	No	No	No	8	9
38	2x50	7x46	Shared	81.2171	22.7427	Yes	Yes	No	No	9	9
39	1x50	2x50	Shared	20.0606	22.7427	No	No	Yes	Yes	9	9
40	2x50	7x49	Shared	62.5365	35.959	Yes	Yes	No	Yes	9	9
41	8x50	8x54	Shared	15.6104	11.9583	Yes	Yes	Yes	No	8	7
42	7x42	Lig	Shared	56.2171	42.8232	Yes	Yes	Yes	Yes	7	0
43	3x33	Lig	Shared	74.5291	15.2532	No	No	Yes	Yes	6	0
44	3x33	4x57	Shared	73.8354	13.4613	No	No	No	No	6	7
45	2x45	4x50	Shared	69.5203	16.8733	No	No	Yes	No	9	9
46	2x45	4x46	Shared	68.0235	19.0967	No	No	No	No	9	7
47	2x42	4x46	Shared	62.6132	18.8481	Yes	Yes	No	No	8	7
48	2x42	3x49	Shared	57.6884	92.5581	Yes	Yes	Yes	No	8	9
49	E2x52	Lig	Shared	62.8103	35.4178	Yes	No	Yes	Yes	4	0
50	E2	E2x52	Shared	58.5864	33.7795	Yes	Yes	Yes	No	3	4
51	5x461	Lig	Shared	12.0035	21.5506	No	No	Yes	Yes	6	0
52	3x37	5x461	Shared	10.828	20.5156	No	No	No	No	6	6
53	3x49	I2x53	Shared	51.6173	19.8537	Yes	No	Yes	Yes	9	7
54	3x51	3x55	Shared	20.0752	14.6645	No	Yes	No	No	8	7
55	6x52	Lig	Shared	14.015	48.3781	Yes	Yes	Yes	Yes	7	0
56	5x47	6x52	Shared	12.5913	14.7632	Yes	Yes	Yes	Yes	7	7
57	1x39	7x39	beta_on	4.35529	30.3675	No	Yes	Yes	Yes	6	6
58	7x39	7x42	beta_on	7.08601	41.9857	Yes	Yes	Yes	Yes	6	7
59	7x38	7x42	beta_on	0.919977	10.693	No	No	Yes	Yes	6	7
60	6x51	7x38	beta_on	0.711887	11.5268	Yes	Yes	No	No	7	6
61	6x48	6x51	beta_on	0.193487	51.5012	Yes	Yes	Yes	Yes	8	7
62	6x48	7x45	beta_on	0	100	Yes	Yes	No	No	8	9
63	7x45	7x49	beta_on	0	97.2353	No	No	No	Yes	9	9
64	6x51	Lig	beta_on	2.05534	37.1	Yes	Yes	Yes	Yes	7	0
65	3x36	Lig	beta_on	1.21568	35.3191	No	No	Yes	Yes	6	0
66	3x36	6x48	beta_on	0.116822	35.7689	No	No	Yes	Yes	6	8
67	6x48	6x52	beta_on	0.872518	35.9298	Yes	Yes	Yes	Yes	8	7
68	1x50	2x51	beta_on	0	13.7319	No	No	No	No	9	7
69	3x43	7x49	beta_on	0	74.4012	No	No	No	Yes	8	9
70	3x43	7x53	beta_on	0	83.6679	No	No	Yes	Yes	8	9
71	3x46	7x53	beta_on	0	86.6264	No	No	Yes	Yes	9	9
72	2x42	3x46	beta_on	2.12471	84.9259	Yes	Yes	No	No	8	9
73	2x39	3x49	beta_on	0	72.3533	No	No	Yes	No	8	9
74	2x37	2x39	beta_on	0	70.0713	No	No	No	No	7	8
75	2x37	2x40	beta_on	1.70853	67.7747	No	No	No	Yes	7	9
76	2x40	8x50	beta_on	3.18341	32.7811	No	Yes	Yes	Yes	9	8
77	3x37	4x53	beta_on	7.2795	16.61	No	No	No	No	6	8
78	3x38	4x53	beta_on	0	16.0249	No	No	No	No	7	8
79	3x38	4x50	beta_on	1.26679	15.8932	No	No	Yes	No	7	9
80	7x54	8x50	beta_on	0	12.4666	No	No	Yes	Yes	6	8
81	2x40	I1x50	beta_on	0	25.6244	No	Yes	No	No	9	8
82	1x60	I1x50	beta_on	6.41063	23.8252	Yes	Yes	No	No	6	8
83	I2x53	I2x57	beta_on	3.73467	12.4593	Yes	Yes	No	No	7	6
84	3x28	Lig	beta_on	0	27.3725	No	Yes	Yes	Yes	6	0
85	3x28	E1x50	beta_on	0.116822	19.9232	No	Yes	Yes	Yes	6	7
86	E1x50	E1x52	beta_on	0.357769	10.1445	Yes	Yes	Yes	Yes	7	5
87	3x40	6x48	beta_on	0	51.4354	No	No	Yes	Yes	8	8
88	3x40	5x50	beta_on	5.38478	67.8844	No	No	Yes	Yes	8	9
89	5x47	6x44	beta_on	0	19.0858	Yes	Yes	Yes	Yes	7	9
90	3x41	5x50	beta_on	0.638873	16.7307	Yes	No	Yes	Yes	6	9
91	3x44	5x50	beta_on	2.52994	46.8459	No	No	Yes	Yes	6	9
92	5x54	6x44	beta_on	0	37.9265	No	No	Yes	Yes	8	9
93	5x54	5x58	beta_on	0	37.3414	No	No	No	Yes	8	9
94	3x44	3x48	beta_on	0	42.9256	No	No	No	No	6	6
95	3x48	3x52	beta_on	1.27409	40.9545	No	No	No	No	6	5
96	3x51	3x52	beta_on	0	38.976	No	Yes	No	No	8	5
97	3x51	5x60	beta_on	3.80768	20.8411	No	Yes	No	Yes	8	5
98	3x55	3x56	beta_on	6.31206	12.591	No	No	Yes	No	7	6
99	3x41	4x52	beta_on	3.95006	12.591	Yes	No	No	No	6	4
100	4x48	4x52	beta_on	2.63946	10.5101	No	No	No	No	3	4
101	5x43	Lig	beta_on	3.99022	13.4394	No	No	Yes	Yes	6	0
102	5x39	5x43	beta_on	3.30023	11.7133	Yes	No	No	No	7	6
103	4x60	5x39	beta_on	0	10.1627	No	No	Yes	No	7	7
104	5x40	E2	beta_on	0	10.1445	No	No	Yes	Yes	6	3
105	5x47	6x49	beta_on	2.57374	16.6904	Yes	Yes	No	Yes	7	7
106	5x58	6x37	beta_on	0	29.1863	No	Yes	No	No	9	8
107	5x58	6x40	beta_on	0	21.4591	No	Yes	No	No	9	8
108	5x62	6x37	beta_on	0	26.2351	No	Yes	No	No	6	8
109	5x62	5x66	beta_on	3.32214	16.0834	No	Yes	No	No	6	5
110	7x52	7x53	beta_on	0	21.6164	No	Yes	Yes	Yes	8	9
111	6x49	6x50	beta_on	0	10.7223	No	Yes	No	No	7	9
112	5x66	6x30	beta_on	0	14.5548	No	No	No	No	5	7
113	5x69	6x30	beta_on	0	11.7608	No	No	No	No	5	7
114	5x60	5x64	beta_on	0	14.6645	No	Yes	No	No	5	6
115	6x39	7x52	beta_on	8.12646	12.9091	No	No	No	Yes	7	8
116	6x39	7x55	beta_on	6.43619	11.0697	No	No	No	No	7	7
117	1x35	2x65	beta_on	0	18.5921	No	No	No	No	4	5
118	1x36	2x65	beta_on	2.52629	20.8448	No	No	No	No	5	5
119	1x36	1x39	beta_on	0	23.2949	No	No	No	Yes	5	6
120	1x31	1x35	beta_on	1.8071	16.1163	No	Yes	No	No	3	4
121	3x50	5x58	beta_on	0	21.3238	Yes	No	No	Yes	9	9
122	2x46	2x50	beta_on	0	13.1103	No	Yes	Yes	Yes	9	9
123	2x46	3x43	beta_on	1.26679	10.3566	No	Yes	No	No	9	8
124	3x40	6x44	beta_on	6.56031	21.6127	No	No	Yes	Yes	8	9
125	3x50	7x53	beta_on	0	21.1995	Yes	No	Yes	Yes	9	9
126	6x40	7x53	beta_on	1.13172	21.1922	No	No	Yes	Yes	8	9

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
2x56	3x32	Shared	6.74381	7.22	1	1	2	1
2x56	7x42	Shared	4.9	4.28	1	1	2	1
2x57	7x42	Shared	3.68345	3.78833	0	0	2	1
2x59	E1x50	Shared	3.6844	3.40667	3	1	2	2
2x59	3x28	Shared	6.3719	8.315	3	1	2	1
2x60	3x28	Shared	3.88571	3.43833	0	0	2	1
3x28	E1x50	Shared	11.0239	9.63222	3	1	1	2
3x29	E2x52	beta_off	6.995	0	0	0	2	1
3x32	7x42	Shared	10.0417	9.57722	1	1	1	1
3x32	Lig	Shared	18.7636	16.7294	1	1	1	0
3x33	4x57	Shared	5.46107	4.30667	0	0	1	2
3x33	Lig	Shared	11.478	9.30389	0	0	1	0
3x36	6x48	Shared	8.47952	9.265	1	0	1	1
3x36	Lig	Shared	5.30226	7.21778	1	0	1	0
3x37	5x461	Shared	8.27798	9.14556	0	0	2	1
3x40	6x44	Shared	6.71667	5.58056	0	0	2	2
E2	E2	Shared	114.868	70.7133	1	1	2	2
E2	E2x52	Shared	14.781	5.93556	1	1	2	1
5x39	E2	Shared	12.0496	7.11778	1	1	2	2
E2	E2x51	Shared	13.1083	9.19722	1	1	2	2
5x39	E2x52	beta_off	4.47119	0	1	1	2	1
E2x52	Lig	Shared	9.03405	16.9139	1	1	1	0
5x39	5x43	Shared	14.0498	9.60889	1	1	2	1
5x43	Lig	Shared	6.96738	5.98056	0	0	1	0
5x44	6x52	Shared	3.63	5.50167	0	0	2	1
5x461	Lig	Shared	3.6619	4.19278	0	0	1	0
5x47	6x52	Shared	31.9971	19.5872	0	1	2	1
6x44	6x48	beta_off	11.1919	0	0	1	2	1
6x44	7x45	beta_off	6.90429	0	0	1	2	2
6x48	6x51	Shared	5.22524	5.29056	1	1	1	1
6x48	6x52	Shared	5.08286	6.01444	1	1	1	1
6x48	7x41	Shared	12.435	10.7117	1	1	1	2
6x48	Lig	beta_off	3.83548	0	1	1	1	0
6x51	6x52	Shared	7.70714	9.11	1	1	1	1
6x51	7x34	Shared	8.48881	5.13556	1	1	1	2
6x51	7x38	Shared	11.4487	15.3056	1	1	1	1
6x51	Lig	Shared	9.14131	7.735	1	1	1	0
6x52	Lig	Shared	11.8045	5.65944	1	1	1	0
6x55	7x34	Shared	4.93857	4.94833	0	1	1	2
6x55	Lig	Shared	8.27119	3.64444	0	1	1	0
7x38	7x42	Shared	12.8913	11.6289	1	1	1	1
7x38	Lig	Shared	13.4844	14.8289	1	1	1	0
7x39	7x42	Shared	13.8236	5.03778	0	0	2	1
7x42	Lig	Shared	5.01417	5.01167	1	1	1	0
7x31	E2x51	beta_off	2.96357	0	0	0	1	2
7x35	7x39	beta_off	2.4	0	0	0	1	2
3x28	Lig	beta_on	0	6.05278	3	1	1	0
3x40	6x48	beta_on	0	6.72	0	0	2	1
5x44	6x55	beta_on	0	4.13889	0	0	2	1
5x47	6x44	beta_on	0	6.78833	0	1	2	2
5x47	6x48	beta_on	0	3.34167	0	1	2	1
6x48	7x45	beta_on	0	7.59611	1	1	1	2
6x51	6x55	beta_on	0	7.38333	1	1	1	1
7x35	Lig	beta_on	0	3.28111	0	0	1	0
3x28	3x29	beta_on	0	2.49444	3	1	1	2
7x31	Lig	beta_on	0	1.68611	0	0	1	0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	beta_off	beta1_off beta2_off
	beta_on	beta1_on beta2_on beta3_on

Network Difference
Value	beta_off	beta_on
I_min	3.57643	3.30556
Number of Linked Nodes	272	263
Number of Specific Nodes	15 (5.51%)	6 (2.28%)
Number of Shared Nodes	257 (94.49%)	257 (97.72%)
Number of Links	293	293
Number of Specific Links	122 (41.64%)	122 (41.64%)
Number of Shared Links	171 (58.36%)	171 (58.36%)
Number of Hubs	37	34
Number of Specific Hubs	18 (48.65%)	15 (44.12%)
Number of Shared Hubs	19 (51.35%)	19 (55.88%)
Average % Shared Neighbours (Jaccard)	44.94
Average % Shared Neighbours (Otsuka)	52.57
Average % Shared Neighbours (Overlap Coefficient)	59.84
Average % Shared Cliques (k3-6)	58.33
Graphlets Similarity	0.663372

Paths Difference
Value	beta_off	beta_on
Number Of Nodes in MetaPath	56	83
Specific Nodes in MetaPath	22 (39.29%)	49 (59.04%)
Shared Nodes in MetaPath	257 (94.49%)	257 (94.49%)
Number Of Links MetaPath	56	90
Specific Links in MetaPath	36 (64.29%)	70 (77.78%)
Shared Links in MetaPath	171 (58.36%)	171 (58.36%)
Number of Shortest Paths	49512	72777
Length Of Smallest Path	3	3
Average Path Length	15.6277	13.6413
Length of Longest Path	39	29
Minimum Path Strength	0.453125	0.280556
Average Path Strength	6.55711	5.45009
Maximum Path Strength	21.9008	15.8714
Minimum Path Correlation	0.701905	0.7
Average Path Correlation	0.913327	0.919705
Maximum Path Correlation	0.989167	0.99
Minimum % Of Corr. Nodes	2.94118	4
Average % Of Corr. Nodes	42.2113	43.7383
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	38.9023	42.849
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download beta_off_on.zip<

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