Orange: nodes, hubs and links specific of blt1_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of blt1_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.


Index Hub Owner blt1_off Avg Int. Strength blt1_on Avg Int. Strength blt1_off Num Of Links blt1_on Num Of Links ConSurf
12x60 blt1_off6.0983312.86626
23x30 blt1_off5.7865.67534
33x41 blt1_off5.094.11536
43x44 blt1_off4.318754.48333437
53x51 blt1_off4.384.81428
6I2x57 blt1_off7.237.99667437
74x49 blt1_off4.05752.48437
84x64 blt1_off4.2329.72534
94x65 blt1_off11.677511.6434
10E2x52 blt1_off6.149.50667535
11E2.Y174 blt1_off5.023750400
125x35 blt1_off5.173756.1422
135x36 blt1_off5.511677.78333633
145x40 blt1_off4.262.85435
155x43 blt1_off5.446.08667435
165x65 blt1_off2.428752.64428
176x44 blt1_off7.861254.88667439
186x47 blt1_off4.0953.49667437
196x55 blt1_off9.043756.83333435
206x61 blt1_off3.10758.29432
217x30 blt1_off3.088753.565424
227x34 blt1_off6.044.09333634
237x42 blt1_off6.798753.50667436
247x49 blt1_off4.423756.8429
25E2.Y172 blt1_off5.268750400
26CT.G309 blt1_off1.213750400
272x50 Shared5.798756.18459
28E1x50 Shared6.336117.528958
29E1x52 Shared10.32875.485447
303x37 Shared6.256254.628457
315x39 Shared3.8166.695544
325x47 Shared6.815.172558
335x50 Shared6.46754.295449
346x48 Shared9.347144.635769
356x51 Shared7.017.8925646
366x52 Shared5.6044.142558
376x58 Shared6.248752.882454
38Lig Shared9.375426.5918212110
391x50 blt1_on6.198336.865349
401x57 blt1_on4.213334.93346
412x43 blt1_on4.692.7075248
422x46 blt1_on4.154.618159
432x64 blt1_on3.671674.67345
443x29 blt1_on14.68337.5075345
453x34 blt1_on5.80254.645245
46E2 blt1_on013.86550113
475x46 blt1_on9.2454.4125244
485x51 blt1_on8.21754.6225246
495x58 blt1_on7.7655.87349
505x64 blt1_on7.1455.895145
51I3 blt1_on04.18054
52E3 blt1_on08.1125042
537x52 blt1_on4.813332.855347
547x53 blt1_on5.5155.244359
557x55 blt1_on1.223.7175147
567x58 blt1_on0.9533332.6075340
577x62 blt1_on3.6455.23250
   
Orange: nodes, hubs and links specific of blt1_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of blt1_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Owner blt1_off Recurrence blt1_on Recurrence blt1_off Hub1? blt1_on Hub1? blt1_off Hub2? blt1_on Hub2? ConSurf1 ConSurf2
17x32 7x35 blt1_off12.45920NoNoNoNo33
27x35 Lig blt1_off13.51492.17175NoNoYesYes30
36x47 7x43 blt1_off11.40340YesNoNoNo75
42x50 Lig blt1_off1000YesYesYesYes90
57x49 7x53 blt1_off41.32380YesNoNoYes99
62x43 7x53 blt1_off37.61630NoYesNoYes89
72x40 I1x48 blt1_off30.2222.57023NoNoNoNo75
8CT.G309 I1x48 blt1_off27.78380YesNoNoNo05
96x40 7x49 blt1_off55.28280NoNoYesNo79
103x46 6x40 blt1_off32.33350NoNoNoNo87
112x42 3x46 blt1_off29.6692.61008NoNoNoNo78
122x42 4x46 blt1_off28.32430NoNoNoNo77
136x36 6x40 blt1_off25.4210NoNoNoNo77
146x36 CT.F317 blt1_off24.04270NoNoNoNo70
152x39 CT.F317 blt1_off23.0540NoNoNoNo70
163x40 6x44 blt1_off93.42690NoNoYesNo79
173x40 3x41 blt1_off52.2790NoNoYesNo76
183x41 4x49 blt1_off13.45620YesNoYesNo67
192x60 E1x50 blt1_off36.77420YesNoYesYes68
202x63 E1x50 blt1_off19.33394.22395NoNoYesYes58
212x63 E2.L169 blt1_off12.42980NoNoNoNo50
22E2.L169 E2.T167 blt1_off11.34060NoNoNoNo00
23E2x52 Lig blt1_off48.88560YesNoYesYes50
24E2.Y174 E2x52 blt1_off23.6280YesNoYesNo05
254x60 5x39 blt1_off29.35484.59255NoNoYesYes84
264x59 4x60 blt1_off26.78262.48057NoNoNoNo48
273x30 4x59 blt1_off24.20190YesNoNoNo44
283x30 4x62 blt1_off13.79562.44073YesNoNoNo44
293x26 4x62 blt1_off11.1730NoNoNoNo74
30E2.Y172 E2x52 blt1_off23.6280YesNoYesNo05
313x40 5x50 blt1_off40.10052.46065NoNoYesYes79
323x41 3x44 blt1_off38.77677.25244YesNoYesNo67
333x44 5x50 blt1_off37.64560.0796971YesNoYesYes79
343x44 5x54 blt1_off68.48350YesNoNoNo78
353x47 5x54 blt1_off65.8193.54652NoNoNoNo98
36I2x53 I2x57 blt1_off13.30540NoNoYesNo67
373x52 I2x53 blt1_off10.40640NoNoNoNo66
384x64 5x35 blt1_off12.06952.1319YesNoYesNo42
395x36 E2.Y174 blt1_off10.25970YesNoYesNo30
405x36 E2.Y172 blt1_off10.25970YesNoYesNo30
417x34 7x38 blt1_off12.15330YesNoNoNo45
426x58 7x34 blt1_off20.24727.30225YesYesYesNo44
436x48 6x51 blt1_off26.56050YesYesYesYes96
445x43 6x51 blt1_off10.4860YesNoYesYes56
456x58 7x30 blt1_off19.29627.36202YesYesYesNo44
466x61 7x30 blt1_off10.46080YesNoYesNo24
475x33 5x36 blt1_off22.2129.95218NoNoYesNo13
48CT.E311 CT.G309 blt1_off18.84790NoNoYesNo00
49CT.E311 CT.L304 blt1_off16.66950NoNoNoNo00
50CT.L304 CT.V315 blt1_off13.40180NoNoNoNo00
517x61 CT.V315 blt1_off12.31250NoNoNoNo00
527x61 CT.L316 blt1_off11.22330NoNoNoNo00
535x33 6x62 blt1_off15.46292.51046NoNoNoNo13
546x59 6x62 blt1_off11.60870NoNoNoNo43
556x48 Lig Shared86.849675.3138YesYesYesYes90
566x48 7x45 Shared17.737751.6637YesYesNoNo99
576x47 7x45 Shared16.166749.9402YesNoNoNo79
587x42 Lig Shared11.7176100YesNoYesYes60
591x39 7x42 Shared11.822431.8589NoNoYesNo76
601x50 2x50 Shared16.170924.5567NoYesYesYes99
611x50 2x51 Shared10.339310.4702NoYesNoNo97
622x50 7x49 Shared89.698450.259YesYesYesNo99
631x57 2x43 Shared36.363615.0229NoYesNoYes68
641x57 2x40 Shared31.600315.9494NoYesNoNo67
652x39 I2x57 Shared18.592413.3293NoNoYesNo77
662x45 4x46 Shared19.002927.7645NoNoNoNo97
672x45 4x50 Shared17.591129.2688NoNoNoNo99
686x44 6x48 Shared98.51722.7336YesNoYesYes99
692x60 Lig Shared41.763729.8267YesNoYesYes60
706x48 6x52 Shared15.538324.7759YesYesYesYes98
713x38 4x50 Shared14.742432.4965NoNoNoNo79
723x38 4x53 Shared13.305434.1602NoNoNoNo77
733x37 4x53 Shared11.860144.1423YesYesNoNo77
743x47 5x58 Shared25.19934.2399NoNoNoYes99
753x50 5x58 Shared12.689612.0442NoNoNoYes99
763x47 5x57 Shared39.065827.4656NoNoNoNo96
773x51 5x57 Shared36.300824.0486YesNoNoNo86
783x51 5x61 Shared22.350220.6117YesNoNoNo88
797x38 Lig Shared15.299513.409NoNoYesYes50
805x47 6x52 Shared16.585714.0167YesYesYesYes88
815x61 5x65 Shared16.694613.678NoNoYesNo88
825x39 5x43 Shared17.32345.9255YesYesYesNo45
836x51 7x34 Shared15.207414.2658YesYesYesNo64
841x38 7x36 blt1_on011.9247NoNoNoNo55
851x45 7x47 blt1_on3.2970310.4702NoNoNoNo67
861x38 7x39 blt1_on017.2544NoNoNoNo54
871x39 7x39 blt1_on1.5877719.7051NoNoNoNo74
882x64 Lig blt1_on5.3958911.7653NoYesYesYes50
891x39 2x61 blt1_on8.9945510.8687NoNoNoNo77
901x46 7x47 blt1_on1.6506117.4836NoNoNoNo87
911x46 1x50 blt1_on022.2056NoNoNoYes89
922x53 7x42 blt1_on0.57394285.266NoNoYesNo66
932x53 7x46 blt1_on083.1739NoNoNoNo69
942x50 7x46 blt1_on3.0121582.8352YesYesNoNo99
952x50 7x50 blt1_on068.7886YesYesNoNo99
961x53 7x50 blt1_on076.3001NoNoNoNo89
971x53 7x55 blt1_on069.4361NoNoNoYes87
981x52 7x55 blt1_on010.9384NoNoNoYes67
997x55 7x62 blt1_on053.6661NoYesNoYes70
1001x56 7x62 blt1_on010.3806NoNoNoYes60
1011x56 1x60 blt1_on014.4252NoNoNoNo65
1021x57 7x62 blt1_on030.8528NoYesNoYes60
1037x61 7x62 blt1_on014.8237NoNoNoYes00
1042x43 7x61 blt1_on012.5922NoYesNoNo80
1052x39 2x43 blt1_on017.9817NoNoNoYes78
1062x46 7x49 blt1_on048.6651NoYesYesNo99
1073x37 Lig blt1_on065.4413YesYesYesYes70
1082x46 3x42 blt1_on1.5249311.1875NoYesNoNo97
1092x46 7x53 blt1_on035.8538NoYesNoYes99
1102x60 3x29 blt1_on0.33514928.4021YesNoNoYes65
1113x25 3x29 blt1_on041.7613NoNoNoYes95
1123x25 E1x50 blt1_on1.5207434.1502NoNoYesYes98
113E1x50 E1x52 blt1_on9.1244225.0946YesYesYesYes87
1144x61 Lig blt1_on030.0458NoNoYesYes40
1153x29 4x61 blt1_on028.7308NoYesNoNo54
1165x43 Lig blt1_on052.6898YesNoYesYes50
1175x39 E2 blt1_on036.581YesYesNoYes40
1183x29 4x65 blt1_on0.41893612.0542NoYesYesNo54
1193x34 4x53 blt1_on012.0442NoYesNoNo57
1203x37 3x41 blt1_on016.8659YesYesYesNo76
1213x50 7x53 blt1_on013.5087NoNoNoYes99
1226x40 7x53 blt1_on026.7185NoNoNoYes79
1235x58 6x40 blt1_on030.8428NoYesNoNo97
1246x43 6x47 blt1_on047.4098NoNoYesNo67
1256x43 7x52 blt1_on0.0083787246.6328NoNoNoYes67
1266x40 7x52 blt1_on036.571NoNoNoYes77
1272x41 4x46 blt1_on8.6175126.589NoNoNoNo77
1282x41 4x39 blt1_on025.9813NoNoNoNo74
1294x38 4x39 blt1_on021.6776NoNoNoNo54
1304x38 4x41 blt1_on4.5580219.3066NoNoNoNo54
1314x41 I2x56 blt1_on016.9157NoNoNoNo44
132I2x52 I2x56 blt1_on4.5077512.4427NoNoNoNo54
1335x36 E2 blt1_on021.6079YesNoNoYes30
1345x43 6x55 blt1_on0.69962319.0875YesNoYesNo55
1355x40 6x55 blt1_on4.3066615.1624YesNoYesNo55
1366x51 7x38 blt1_on2.67711.4365YesYesNoNo65
1375x47 6x44 blt1_on011.6557YesYesYesNo89
1385x47 6x49 blt1_on6.1457915.4015YesYesNoNo85
1395x65 I3 blt1_on010.1614YesNoNoYes80
1406x36 7x52 blt1_on026.4893NoNoNoYes77
1416x36 7x58 blt1_on021.9865NoNoNoYes70
1426x32 7x58 blt1_on010.1016NoNoNoYes70
1432x41 I1x51 blt1_on2.9870117.1847NoNoNoNo76
1442x40 I1x51 blt1_on016.587NoNoNoNo76

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Midway



Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Node1Node2OwnerNet1LinkStrengthNet2LinkStrengthComm1Comm2Node1ShellNode2Shell
1x397x42Shared9.7454.870021
1x502x50Shared5.38512.120521
1x507x50Shared9.7758.150522
2x507x46Shared7.365.890512
2x507x49Shared5.3856.730512
2x50Ligblt1_off5.06500510
2x533x35Shared6.464.851012
2x537x42Shared3.2752.621011
2x53Ligblt1_off8.601010
2x60E1x50blt1_off3.5101012
2x603x28blt1_off4.1901012
2x603x29Shared6.796.791011
2x607x42blt1_off3.21501011
2x60LigShared16.2918.931010
2x64LigShared6.4311.180010
3x25E1x50Shared11.19.141122
3x28E1x50blt1_off3.9201022
3x294x65Shared22.5714.671011
3x29Ligblt1_off14.6901010
3x32Ligblt1_off8.300010
3x366x48Shared11.633.491211
3x366x52blt1_off3.28501212
3x374x53Shared3.182.540212
3x374x56Shared9.3810.550212
3x375x46Shared8.1153.750212
3x375x461blt1_off4.3500212
3x396x44blt1_off3.300022
4x614x65blt1_off5.2300011
4x65E2x52Shared12.82515.851111
E2.Y174E2x52blt1_off3.33501021
5x39E2.Y174blt1_off4.35501122
5x395x43Shared3.0757.391121
5x436x51blt1_off6.1701012
5x436x55Shared9.132.631012
6x446x48Shared21.055.010221
6x486x51blt1_off4.8201212
6x486x52Shared4.763.171212
6x487x41Shared4.545.191212
6x487x45Shared7.417.411212
6x48LigShared11.223.541210
6x516x52Shared8.1655.441022
6x516x55Shared13.8615.121022
6x517x34Shared3.6056.171022
6x517x38Shared5.444.841021
6x557x34blt1_off8.40501022
7x347x38blt1_off5.0101821
7x35LigShared8.0956.830010
7x38LigShared12.96.211010
7x42LigShared10.963.031010
4x65Ligblt1_off6.08501110
E2x52Ligblt1_off3.8701110
3x365x43blt1_off3.38501211
E2x51E2x52Shared6.54.330121
E2.Y172E2x52blt1_off4.1701021
5x39E2.Y172blt1_off3.26501122
1x322x64Shared3.0051.50021
2x562x60blt1_off2.59500021
7x327x35blt1_off2.100021
3x323x33Shared1.961.960011
1x352x64Shared1.583.150021
1x362x64blt1_on02.850021
2x503x39blt1_on02.940512
2x507x50blt1_on03.220512
2x537x46blt1_on06.461012
2x563x32blt1_on06.760021
3x253x29blt1_on04.421121
3x294x61blt1_on04.151011
3x36Ligblt1_on05.271210
3x37Ligblt1_on04.370210
4x565x46blt1_on02.950222
4x61Ligblt1_on02.780010
4x65E2x51blt1_on04.281112
E2E2blt1_on035.950122
E2E2x51blt1_on08.990122
E2E2x52blt1_on08.340121
5x39E2blt1_on011.981122
5x43Ligblt1_on08.241010
3x33Ligblt1_on02.130010
3x373x41blt1_on01.930212
5x4616x52blt1_on01.590022

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
Id Description
blt1_off 5X33-BLT1-BIIL260
7K15-BLT1-MKD046-Na
blt1_on 7VKT-BLT1-LTB4-Gi1/β1/γ2
Network Difference
Value blt1_off blt1_on
Imin 3.035 2.54
Number of Linked Nodes 308 236
Number of Specific Nodes 86 (27.92%) 14  (5.93%)
Number of Shared Nodes 222 (72.08%) 222  (94.07%)
Number of Links 335 260
Number of Specific Links 193 (57.61%) 118  (45.38%)
Number of Shared Links 142 (42.39%) 142  (54.62%)
Number of Hubs 38 31
Number of Specific Hubs 26 (68.42%) 19  (61.29%)
Number of Shared Hubs 12 (31.58%) 12  (38.71%)
Average % Shared Neighbours (Jaccard) 29.91
Average % Shared Neighbours (Otsuka) 37.09
Average % Shared Neighbours (Overlap Coefficient) 44.51
Average % Shared Cliques (k3-6) 76.97
Graphlets Similarity 0.509298
Paths Difference
Value blt1_off blt1_on
Number Of Nodes in MetaPath 82 85
Specific Nodes in MetaPath 38 (46.34%) 41  (48.24%)
Shared Nodes in MetaPath 222 (72.08%) 222  (72.08%)
Number Of Links MetaPath 83 90
Specific Links in MetaPath 54 (65.06%) 61  (67.78%)
Shared Links in MetaPath 142 (42.39%) 142  (42.39%)
Number of Shortest Paths 60451 31498
Length Of Smallest Path 3 3
Average Path Length 12.9109 11.4841
Length of Longest Path 31 30
Minimum Path Strength 0.7625 1.38
Average Path Strength 5.65262 4.86325
Maximum Path Strength 17.6975 15.825
Minimum Path Correlation 0.7 0.7
Average Path Correlation 0.916604 0.920745
Maximum Path Correlation 0.99 0.99
Minimum % Of Corr. Nodes 3.44828 4.34783
Average % Of Corr. Nodes 44.6825 53.4113
Maximum % Of Corr. Nodes 100 100
Minimum Path Hubs % 0 0
Average Path Hubs % 46.1132 36.4988
Maximum Path Hubs % 100 100

Details about the values in these tables can be found in the corresponding documentation page .

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