psnGPCR

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Orange: nodes, hubs and links specific of cannabinoid_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of cannabinoid_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	cannabinoid_off Int. Strength	cannabinoid_on Int. Strength	cannabinoid_off Hub1?	cannabinoid_on Hub1?	cannabinoid_off Hub2?	cannabinoid_on Hub2?	ConSurf1	ConSurf2
1	6x48	Lig	cannabinoid_off	100	0	Yes	Yes	Yes	Yes	8	0
2	6x51	Lig	cannabinoid_off	100	0	No	No	Yes	Yes	6	0
3	7x41	Lig	cannabinoid_off	100	0	No	No	Yes	Yes	7	0
4	3x25	NT	cannabinoid_off	100	0	No	Yes	Yes	Yes	9	5
5	1x39	2x61	cannabinoid_off	100	0	No	No	Yes	Yes	6	6
6	1x45	1x49	cannabinoid_off	100	0	No	No	Yes	No	4	8
7	2x39	2x40	cannabinoid_off	100	0	No	No	Yes	Yes	8	8
8	2x39	3x50	cannabinoid_off	100	0	No	No	Yes	No	8	9
9	2x43	7x53	cannabinoid_off	100	0	No	No	No	Yes	8	9
10	2x46	7x53	cannabinoid_off	100	0	No	Yes	No	Yes	9	9
11	2x48	2x52	cannabinoid_off	100	0	No	No	No	No	7	7
12	3x28	E1	cannabinoid_off	100	0	No	No	Yes	Yes	5	4
13	3x45	4x46	cannabinoid_off	100	0	No	No	No	No	6	8
14	3x49	3x50	cannabinoid_off	100	0	Yes	Yes	Yes	No	9	9
15	3x50	3x53	cannabinoid_off	100	0	Yes	No	No	No	9	8
16	3x50	5x61	cannabinoid_off	100	0	Yes	No	No	No	9	9
17	3x50	6x30	cannabinoid_off	100	0	Yes	No	Yes	Yes	9	7
18	3x50	6x33	cannabinoid_off	100	0	Yes	No	No	No	9	7
19	3x53	6x30	cannabinoid_off	100	0	No	No	Yes	Yes	8	7
20	3x54	5x68	cannabinoid_off	100	0	No	No	No	No	9	7
21	I2x53	I2x57	cannabinoid_off	100	0	Yes	Yes	No	No	7	6
22	4x59	5x39	cannabinoid_off	100	0	No	No	No	Yes	5	7
23	4x60	E2	cannabinoid_off	100	0	No	No	Yes	Yes	5	5
24	5x40	6x59	cannabinoid_off	100	0	No	No	Yes	No	5	3
25	5x58	5x62	cannabinoid_off	100	0	Yes	Yes	No	No	9	6
26	5x58	6x38	cannabinoid_off	100	0	Yes	Yes	No	No	9	6
27	5x63	5x64	cannabinoid_off	100	0	No	No	Yes	No	3	6
28	5x64	5x67	cannabinoid_off	100	0	Yes	No	No	No	6	5
29	5x68	I3	cannabinoid_off	100	0	No	No	No	Yes	7	3
30	6x28	8x48	cannabinoid_off	100	0	No	No	No	No	4	4
31	6x32	8x48	cannabinoid_off	100	0	No	No	No	No	8	4
32	6x35	7x56	cannabinoid_off	100	0	No	No	Yes	No	7	7
33	6x40	7x49	cannabinoid_off	100	0	No	No	Yes	No	8	9
34	6x44	6x48	cannabinoid_off	100	0	No	No	Yes	Yes	9	8
35	6x44	7x45	cannabinoid_off	100	0	No	No	Yes	No	9	9
36	6x51	7x41	cannabinoid_off	100	0	No	No	No	No	6	7
37	6x58	E3	cannabinoid_off	100	0	No	No	No	Yes	3	1
38	7x27	7x29	cannabinoid_off	100	0	No	No	No	No	2	3
39	7x27	7x30	cannabinoid_off	100	0	No	No	Yes	No	2	3
40	Lig	NT	cannabinoid_off	100	0	Yes	Yes	Yes	Yes	0	5
41	7x39	Lig	cannabinoid_off	100	0	No	No	Yes	Yes	5	0
42	2x60	NT	cannabinoid_off	100	0	No	No	Yes	Yes	4	5
43	3x28	NT	cannabinoid_off	100	0	No	No	Yes	Yes	5	5
44	2x57	NT	cannabinoid_off	100	0	No	Yes	Yes	Yes	6	5
45	1x31	NT	cannabinoid_off	100	0	No	No	Yes	Yes	5	5
46	2x41	4x46	cannabinoid_off	100	0	No	No	No	No	4	8
47	2x42	2x43	cannabinoid_off	100	0	Yes	No	No	No	8	8
48	2x42	6x37	cannabinoid_off	100	0	Yes	No	No	No	8	8
49	5x59	5x63	cannabinoid_off	100	0	No	No	No	No	3	3
50	6x25	6x28	cannabinoid_off	100	0	No	No	No	No	0	4
51	6x26	6x30	cannabinoid_off	100	0	No	No	Yes	Yes	0	7
52	7x49	7x53	cannabinoid_off	100	0	Yes	No	No	Yes	9	9
53	1x28	NT	cannabinoid_off	100	0	No	No	Yes	Yes	7	5
54	1x53	2x47	cannabinoid_off	25	0	No	No	No	No	9	9
55	2x48	4x50	cannabinoid_off	50	0	No	No	Yes	Yes	7	9
56	1x47	2x54	cannabinoid_off	50	0	No	No	No	No	6	8
57	3x36	3x40	cannabinoid_off	50	0	Yes	Yes	No	No	6	8
58	5x42	E2	cannabinoid_off	50	0	No	No	Yes	Yes	5	5
59	5x43	5x44	cannabinoid_off	50	0	Yes	Yes	No	No	5	4
60	1x57	I1x50	cannabinoid_off	50	0	No	No	No	No	8	8
61	5x51	6x45	cannabinoid_off	50	0	No	Yes	No	No	7	6
62	2x42	3x46	cannabinoid_off	50	0	Yes	No	No	No	8	9
63	1x40	2x61	cannabinoid_off	50	0	No	No	Yes	Yes	5	6
64	2x46	3x39	cannabinoid_off	0	0	No	Yes	No	No	9	9
65	3x52	I2x57	cannabinoid_off	50	0	No	No	No	No	5	6
66	6x29	6x32	cannabinoid_off	50	0	No	No	No	No	5	8
67	6x54	7x30	cannabinoid_off	50	0	No	No	Yes	No	4	3
68	6x32	7x56	cannabinoid_off	50	0	No	No	Yes	No	8	7
69	1x47	2x55	cannabinoid_off	50	0	No	No	No	No	6	4
70	2x38	I2x53	cannabinoid_off	50	0	No	No	Yes	Yes	5	7
71	6x30	I3	cannabinoid_off	50	0	Yes	Yes	No	Yes	7	3
72	6x26	6x29	cannabinoid_off	50	0	No	No	No	No	0	5
73	8x49	I1x49	cannabinoid_off	50	0	No	No	No	No	6	6
74	3x31	4x58	cannabinoid_off	50	0	No	No	Yes	No	4	4
75	4x58	4x62	cannabinoid_off	50	0	Yes	No	No	No	4	4
76	6x47	7x43	cannabinoid_off	25	0	No	No	No	No	8	4
77	3x43	5x58	cannabinoid_off	50	0	No	No	Yes	Yes	8	9
78	2x38	4x42	cannabinoid_off	25	0	No	No	No	No	5	7
79	6x43	7x45	cannabinoid_off	25	0	No	No	Yes	No	7	9
80	1x57	2x44	cannabinoid_off	0	0	No	No	No	No	8	7
81	3x30	4x58	cannabinoid_off	50	0	No	No	Yes	No	6	4
82	1x43	7x42	cannabinoid_off	50	0	No	No	No	No	7	6
83	3x36	6x52	cannabinoid_off	50	0	Yes	Yes	No	No	6	6
84	6x57	7x30	cannabinoid_off	50	0	No	No	Yes	No	4	3
85	4x54	4x58	cannabinoid_off	0	0	No	No	Yes	No	3	4
86	3x50	6x34	cannabinoid_off	0	0	Yes	No	No	No	9	8
87	5x68	6x31	cannabinoid_off	50	0	No	No	No	No	7	5
88	5x65	6x31	cannabinoid_off	0	0	No	No	No	No	8	5
89	6x47	7x40	cannabinoid_off	0	0	No	No	No	No	8	8
90	6x59	6x60	cannabinoid_off	50	0	Yes	No	No	No	3	4
91	7x55	8x51	cannabinoid_off	50	0	No	No	No	No	6	8
92	5x69	I3	cannabinoid_off	0	0	No	No	No	Yes	5	3
93	5x66	6x31	cannabinoid_off	25	0	No	No	No	No	5	5
94	7x35	NT	cannabinoid_off	25	0	No	No	Yes	Yes	4	5
95	5x45	5x48	cannabinoid_off	25	0	No	No	No	No	3	4
96	6x56	6x57	cannabinoid_off	25	0	No	No	No	No	5	4
97	7x30	7x33	cannabinoid_off	0	0	Yes	No	No	No	3	3
98	4x44	4x48	cannabinoid_off	0	0	No	No	No	No	3	3
99	4x55	4x59	cannabinoid_off	0	0	No	No	No	No	3	5
100	5x49	5x53	cannabinoid_off	25	0	No	No	No	No	4	5
101	1x60	8x57	cannabinoid_off	0	0	No	No	No	No	7	6
102	4x43	4x47	cannabinoid_off	0	0	No	No	No	No	1	4
103	I1	I1x51	cannabinoid_off	0	0	No	No	No	No	7	3
104	1x54	1x58	cannabinoid_off	0	0	No	No	No	No	7	4
105	6x24	6x27	cannabinoid_off	0	0	No	No	No	No	0	0
106	5x69	6x27	cannabinoid_off	0	0	No	No	No	No	5	0
107	1x44	2x58	cannabinoid_off	0	0	No	No	No	No	5	6
108	4x51	4x52	cannabinoid_off	0	0	No	No	No	No	3	4
109	1x33	1x37	cannabinoid_off	0	0	No	No	No	No	4	5
110	1x52	1x56	cannabinoid_off	0	0	No	No	No	No	7	8
111	1x59	8x56	cannabinoid_off	0	0	No	No	No	No	5	5
112	8x54	8x58	cannabinoid_off	0	0	No	No	No	No	6	6
113	2x57	Lig	Shared	100	100	No	Yes	Yes	Yes	6	0
114	2x64	Lig	Shared	100	100	No	Yes	Yes	Yes	3	0
115	3x29	Lig	Shared	100	100	No	No	Yes	Yes	4	0
116	3x32	Lig	Shared	100	100	No	No	Yes	Yes	5	0
117	3x33	Lig	Shared	100	100	No	Yes	Yes	Yes	4	0
118	3x36	Lig	Shared	100	100	Yes	Yes	Yes	Yes	6	0
119	E2	Lig	Shared	100	100	Yes	Yes	Yes	Yes	5	0
120	5x43	Lig	Shared	100	100	Yes	Yes	Yes	Yes	5	0
121	7x38	Lig	Shared	100	100	No	No	Yes	Yes	5	0
122	NT	NT	Shared	100	100	Yes	Yes	Yes	Yes	5	5
123	E2	NT	Shared	100	100	Yes	Yes	Yes	Yes	5	5
124	2x64	NT	Shared	100	100	No	Yes	Yes	Yes	3	5
125	E1	NT	Shared	100	100	Yes	Yes	Yes	Yes	4	5
126	7x28	NT	Shared	100	28.3333	No	No	Yes	Yes	3	5
127	7x31	NT	Shared	100	100	No	No	Yes	Yes	2	5
128	7x32	NT	Shared	100	100	No	No	Yes	Yes	2	5
129	1x32	NT	Shared	100	100	No	No	Yes	Yes	5	5
130	1x28	1x31	Shared	100	100	No	No	No	No	7	5
131	1x32	2x66	Shared	100	100	No	No	Yes	Yes	5	4
132	1x38	7x39	Shared	100	100	No	No	No	No	5	5
133	1x39	7x39	Shared	100	100	No	No	No	No	6	5
134	1x46	2x54	Shared	100	100	No	No	No	No	7	8
135	1x46	7x47	Shared	100	100	No	No	No	Yes	7	6
136	1x49	7x47	Shared	100	100	Yes	No	No	Yes	8	6
137	1x49	7x50	Shared	100	100	Yes	No	No	No	8	9
138	1x50	2x50	Shared	100	100	No	Yes	No	Yes	9	9
139	1x50	7x50	Shared	100	100	No	Yes	No	No	9	9
140	1x55	1x59	Shared	100	100	No	No	No	No	5	5
141	1x59	8x57	Shared	100	50	No	No	No	No	5	6
142	1x60	I1x50	Shared	100	100	No	No	No	No	7	8
143	1x60	8x53	Shared	100	45	No	No	No	No	7	7
144	2x40	I1x50	Shared	100	100	Yes	Yes	No	No	8	8
145	4x39	I1	Shared	100	75	No	Yes	No	No	3	7
146	2x37	2x40	Shared	100	100	No	No	Yes	Yes	6	8
147	2x37	8x49	Shared	100	100	No	No	No	No	6	6
148	2x40	8x47	Shared	100	100	Yes	Yes	No	No	8	8
149	2x40	8x49	Shared	100	100	Yes	Yes	No	No	8	6
150	2x42	3x49	Shared	100	100	Yes	No	Yes	Yes	8	9
151	2x45	3x42	Shared	100	100	No	No	No	No	9	8
152	2x45	4x46	Shared	100	100	No	No	No	No	9	8
153	2x45	4x50	Shared	100	100	No	No	Yes	Yes	9	9
154	2x50	7x46	Shared	100	100	No	Yes	No	No	9	9
155	2x50	7x49	Shared	100	100	No	Yes	Yes	No	9	9
156	2x51	2x55	Shared	100	50	No	Yes	No	No	7	4
157	2x57	7x42	Shared	100	100	No	Yes	No	No	6	6
158	2x61	2x65	Shared	100	100	Yes	Yes	No	Yes	6	4
159	2x62	2x66	Shared	100	100	No	No	Yes	Yes	5	4
160	2x63	E1	Shared	100	100	No	No	Yes	Yes	3	4
161	2x64	2x65	Shared	100	100	No	Yes	No	Yes	3	4
162	2x66	E1	Shared	100	100	Yes	Yes	Yes	Yes	4	4
163	3x24	E1	Shared	100	100	No	No	Yes	Yes	4	4
164	3x21	3x24	Shared	100	100	No	No	No	No	6	4
165	3x22	E2	Shared	100	100	No	No	Yes	Yes	3	5
166	3x25	E2	Shared	100	100	No	Yes	Yes	Yes	9	5
167	3x26	4x61	Shared	100	100	No	No	No	No	5	6
168	3x26	E2	Shared	100	100	No	No	Yes	Yes	5	5
169	3x29	E2	Shared	100	100	No	No	Yes	Yes	4	5
170	3x33	4x57	Shared	100	100	No	Yes	No	No	4	7
171	3x33	5x43	Shared	100	100	No	Yes	Yes	Yes	4	5
172	3x36	6x48	Shared	100	100	Yes	Yes	Yes	Yes	6	8
173	3x37	4x53	Shared	100	100	No	No	No	No	6	8
174	3x37	5x43	Shared	100	100	No	No	Yes	Yes	6	5
175	3x38	4x50	Shared	100	100	No	No	Yes	Yes	7	9
176	3x40	5x50	Shared	100	100	No	No	No	Yes	8	7
177	3x40	5x51	Shared	100	100	No	No	No	Yes	8	7
178	3x41	4x49	Shared	100	100	No	No	No	No	5	6
179	3x44	3x48	Shared	100	100	Yes	Yes	No	No	6	6
180	3x44	5x50	Shared	100	100	Yes	Yes	No	Yes	6	7
181	3x44	5x54	Shared	100	100	Yes	Yes	No	No	6	8
182	3x45	4x49	Shared	100	100	No	No	No	No	6	6
183	3x49	I2x53	Shared	100	100	Yes	Yes	Yes	Yes	9	7
184	3x49	I2x57	Shared	100	100	Yes	Yes	No	No	9	6
185	3x51	3x55	Shared	100	100	No	No	No	No	8	6
186	3x53	I2x53	Shared	100	100	No	No	Yes	Yes	8	7
187	3x55	3x56	Shared	100	100	No	No	No	No	6	5
188	4x38	4x41	Shared	100	100	No	No	No	No	9	6
189	4x49	4x50	Shared	100	100	No	No	Yes	Yes	6	9
190	4x59	E2	Shared	100	100	No	No	Yes	Yes	5	5
191	4x60	5x39	Shared	100	100	No	No	No	Yes	5	7
192	E2	E2	Shared	100	100	Yes	Yes	Yes	Yes	5	5
193	5x36	E2	Shared	100	100	No	No	Yes	Yes	4	5
194	5x38	E2	Shared	100	100	No	No	Yes	Yes	4	5
195	5x39	E2	Shared	100	100	No	Yes	Yes	Yes	7	5
196	5x37	E2	Shared	100	100	No	No	Yes	Yes	4	5
197	6x58	E2	Shared	100	100	No	No	Yes	Yes	3	5
198	E2	E3	Shared	100	100	Yes	Yes	No	Yes	5	1
199	7x31	E2	Shared	100	100	No	No	Yes	Yes	2	5
200	6x55	E2	Shared	100	100	No	No	Yes	Yes	6	5
201	7x34	E2	Shared	100	100	No	Yes	Yes	Yes	4	5
202	5x40	E2	Shared	100	100	No	No	Yes	Yes	5	5
203	5x36	5x38	Shared	100	100	No	No	No	No	4	4
204	5x37	6x59	Shared	100	50	No	No	Yes	No	4	3
205	5x41	6x59	Shared	100	100	No	No	Yes	No	4	3
206	5x43	5x47	Shared	100	100	Yes	Yes	No	No	5	7
207	5x46	5x50	Shared	100	100	No	No	No	Yes	5	7
208	5x56	5x60	Shared	100	100	No	No	No	Yes	4	5
209	5x58	6x37	Shared	100	100	Yes	Yes	No	No	9	8
210	5x58	6x41	Shared	100	100	Yes	Yes	No	No	9	7
211	6x36	7x56	Shared	100	100	No	No	Yes	No	8	7
212	6x39	7x56	Shared	100	100	No	No	Yes	No	6	7
213	6x43	7x48	Shared	100	100	No	No	No	No	7	6
214	6x47	7x45	Shared	100	100	No	No	Yes	No	8	9
215	6x48	7x41	Shared	100	100	Yes	Yes	No	No	8	7
216	6x48	7x45	Shared	100	100	Yes	Yes	Yes	No	8	9
217	6x49	6x50	Shared	100	100	No	No	No	No	5	9
218	6x50	7x37	Shared	100	26.6667	No	No	No	No	9	4
219	6x51	7x34	Shared	100	100	No	No	No	Yes	6	4
220	6x54	7x34	Shared	100	100	No	No	No	Yes	4	4
221	6x57	6x61	Shared	100	50	No	No	No	No	4	3
222	7x45	7x49	Shared	100	100	Yes	No	Yes	No	9	9
223	8x47	8x50	Shared	100	100	No	No	No	No	8	8
224	I1x48	I1x51	Shared	100	18.3333	No	No	No	No	5	3
225	2x59	2x63	Shared	100	100	No	No	No	No	7	3
226	2x60	3x28	Shared	100	100	No	No	No	No	4	5
227	5x60	5x64	Shared	100	100	No	Yes	Yes	No	5	6
228	8x48	8x51	Shared	100	100	No	No	No	No	4	8
229	1x32	1x33	Shared	50	10	No	No	No	No	5	4
230	3x51	5x60	Shared	50	100	No	No	No	Yes	8	5
231	3x22	3x23	Shared	50	50	No	No	No	No	3	1
232	5x55	6x41	Shared	50	100	No	No	No	No	5	7
233	3x54	5x64	Shared	50	100	No	No	Yes	No	9	6
234	1x56	8x54	Shared	25	66.6667	No	No	No	No	8	6
235	3x34	4x57	Shared	50	100	No	No	No	No	5	7
236	I2x52	I2x55	Shared	50	10	No	No	No	No	5	4
237	4x38	4x40	Shared	50	100	No	No	No	No	9	4
238	3x56	I2x52	Shared	50	26.6667	No	No	No	No	5	5
239	1x51	2x51	Shared	50	60	No	No	No	Yes	5	7
240	2x46	3x42	Shared	50	100	No	Yes	No	No	9	8
241	3x34	4x58	Shared	50	100	No	No	Yes	No	5	4
242	2x52	3x35	Shared	0	100	No	No	No	No	7	7
243	3x52	I2x56	Shared	50	28.3333	No	No	No	No	5	4
244	1x54	2x48	Shared	50	100	No	No	No	No	7	7
245	I2x50	I2x51	Shared	50	100	No	No	No	No	8	7
246	1x42	7x47	Shared	25	100	No	Yes	No	Yes	6	6
247	2x41	4x43	Shared	50	50	No	No	No	No	4	1
248	1x54	2x47	Shared	0	66.6667	No	No	No	No	7	9
249	1x56	8x53	Shared	50	25	No	No	No	No	8	7
250	3x47	5x58	Shared	50	100	No	No	Yes	Yes	9	9
251	4x56	5x46	Shared	50	100	No	No	No	No	5	5
252	6x40	7x52	Shared	50	100	No	No	No	Yes	8	9
253	2x53	3x35	Shared	25	100	No	No	No	No	8	7
254	4x63	E2	Shared	50	28.3333	No	No	Yes	Yes	4	5
255	2x49	4x50	Shared	0	36.6667	No	No	Yes	Yes	8	9
256	1x44	1x48	Shared	0	8.33333	No	No	No	No	5	4
257	1x55	8x61	Shared	50	16.6667	No	No	No	No	5	3
258	6x54	7x37	Shared	25	38.3333	No	No	No	No	4	4
259	3x51	5x57	Shared	25	60	No	No	No	No	8	6
260	1x49	7x51	Shared	0	26.6667	Yes	No	No	No	8	6
261	1x28	1x29	Shared	50	100	No	No	No	No	7	4
262	1x29	1x30	Shared	50	50	No	No	No	No	4	4
263	2x41	4x39	Shared	25	50	No	No	No	Yes	4	3
264	1x35	2x61	Shared	50	58.3333	No	No	Yes	Yes	5	6
265	1x35	7x36	Shared	50	100	No	No	No	Yes	5	4
266	2x56	3x32	Shared	0	46.6667	No	No	No	No	4	5
267	1x43	2x58	Shared	0	0	No	No	No	No	7	6
268	8x51	8x55	Shared	50	10	No	No	No	No	8	4
269	1x36	2x66	Shared	0	50	No	No	Yes	Yes	5	4
270	3x45	4x45	Shared	25	50	No	No	No	No	6	6
271	6x42	6x46	Shared	0	10	No	No	No	No	5	5
272	4x48	4x52	Shared	0	20	No	No	No	No	3	4
273	8x58	8x62	Shared	0	16.6667	No	No	No	No	6	4
274	5x41	5x45	Shared	0	8.33333	No	No	No	No	4	3
275	6x49	6x53	Shared	0	16.6667	No	No	No	No	5	5
276	3x44	5x53	Shared	25	100	Yes	Yes	No	No	6	5
277	3x27	4x61	Shared	0	45	No	No	No	No	4	6
278	1x37	1x41	Shared	0	0	No	No	No	No	5	4
279	8x52	8x56	Shared	25	18.3333	No	No	No	No	4	5
280	5x66	5x70	Shared	25	50	No	No	No	No	5	5
281	6x38	6x42	Shared	0	0	No	No	No	No	6	5
282	4x52	4x56	Shared	0	8.33333	No	No	No	No	4	5
283	3x56	I2x50	Shared	0	0	No	No	No	No	5	8
284	4x39	4x40	Shared	0	8.33333	No	Yes	No	No	3	4
285	I2x53	I2x54	Shared	0	100	Yes	Yes	No	No	7	5
286	2x65	NT	cannabinoid_on	0	100	No	Yes	Yes	Yes	4	5
287	1x31	7x36	cannabinoid_on	0	100	No	No	No	Yes	5	4
288	1x42	7x42	cannabinoid_on	0	100	No	Yes	No	No	6	6
289	1x45	7x47	cannabinoid_on	0	100	No	No	No	Yes	4	6
290	1x47	2x51	cannabinoid_on	0	100	No	No	No	Yes	6	7
291	1x53	7x54	cannabinoid_on	0	100	No	No	No	No	9	8
292	2x37	2x38	cannabinoid_on	0	100	No	No	No	No	6	5
293	2x38	I2x57	cannabinoid_on	0	100	No	No	No	No	5	6
294	2x39	3x49	cannabinoid_on	0	100	No	No	Yes	Yes	8	9
295	2x40	8x50	cannabinoid_on	0	100	Yes	Yes	No	No	8	8
296	2x42	3x45	cannabinoid_on	0	100	Yes	No	No	No	8	6
297	2x46	2x50	cannabinoid_on	0	100	No	Yes	No	Yes	9	9
298	2x46	3x43	cannabinoid_on	0	100	No	Yes	No	No	9	8
299	2x46	7x49	cannabinoid_on	0	100	No	Yes	Yes	No	9	9
300	2x57	2x61	cannabinoid_on	0	100	No	Yes	Yes	Yes	6	6
301	2x57	3x32	cannabinoid_on	0	100	No	Yes	No	No	6	5
302	2x57	7x38	cannabinoid_on	0	100	No	Yes	No	No	6	5
303	2x60	Lig	cannabinoid_on	0	100	No	No	Yes	Yes	4	0
304	2x61	Lig	cannabinoid_on	0	100	Yes	Yes	Yes	Yes	6	0
305	2x64	E1	cannabinoid_on	0	100	No	Yes	Yes	Yes	3	4
306	2x64	3x25	cannabinoid_on	0	100	No	Yes	No	Yes	3	9
307	2x65	Lig	cannabinoid_on	0	100	No	Yes	Yes	Yes	4	0
308	3x25	E1	cannabinoid_on	0	100	No	Yes	Yes	Yes	9	4
309	3x25	3x29	cannabinoid_on	0	100	No	Yes	No	No	9	4
310	3x36	7x41	cannabinoid_on	0	100	Yes	Yes	No	No	6	7
311	3x40	6x48	cannabinoid_on	0	100	No	No	Yes	Yes	8	8
312	3x43	7x53	cannabinoid_on	0	100	No	No	No	Yes	8	9
313	3x46	3x50	cannabinoid_on	0	100	No	No	Yes	No	9	9
314	3x46	7x53	cannabinoid_on	0	100	No	No	No	Yes	9	9
315	3x50	5x58	cannabinoid_on	0	100	Yes	No	Yes	Yes	9	9
316	3x50	7x53	cannabinoid_on	0	100	Yes	No	No	Yes	9	9
317	3x54	5x61	cannabinoid_on	0	100	No	No	No	No	9	9
318	3x55	5x60	cannabinoid_on	0	100	No	No	No	Yes	6	5
319	4x46	4x50	cannabinoid_on	0	100	No	No	Yes	Yes	8	9
320	5x39	5x43	cannabinoid_on	0	100	No	Yes	Yes	Yes	7	5
321	5x39	Lig	cannabinoid_on	0	100	No	Yes	Yes	Yes	7	0
322	5x43	6x55	cannabinoid_on	0	100	Yes	Yes	No	No	5	6
323	5x44	6x52	cannabinoid_on	0	100	No	No	No	No	4	6
324	5x44	6x55	cannabinoid_on	0	100	No	No	No	No	4	6
325	5x47	5x51	cannabinoid_on	0	100	No	No	No	Yes	7	7
326	5x51	6x44	cannabinoid_on	0	100	No	Yes	No	No	7	9
327	5x51	6x48	cannabinoid_on	0	100	No	Yes	Yes	Yes	7	8
328	5x58	6x40	cannabinoid_on	0	100	Yes	Yes	No	No	9	8
329	5x58	7x53	cannabinoid_on	0	100	Yes	Yes	No	Yes	9	9
330	5x62	6x37	cannabinoid_on	0	100	No	No	No	No	6	8
331	5x66	6x30	cannabinoid_on	0	100	No	No	Yes	Yes	5	7
332	5x69	6x30	cannabinoid_on	0	100	No	No	Yes	Yes	5	7
333	6x28	6x32	cannabinoid_on	0	100	No	No	No	No	4	8
334	6x39	7x52	cannabinoid_on	0	100	No	No	No	Yes	6	9
335	6x40	7x53	cannabinoid_on	0	100	No	No	No	Yes	8	9
336	6x43	7x52	cannabinoid_on	0	100	No	No	No	Yes	7	9
337	6x57	E3	cannabinoid_on	0	100	No	No	No	Yes	4	1
338	7x30	E3	cannabinoid_on	0	100	Yes	No	No	Yes	3	1
339	7x29	7x32	cannabinoid_on	0	100	No	No	No	No	3	2
340	7x34	Lig	cannabinoid_on	0	100	No	Yes	Yes	Yes	4	0
341	7x52	7x53	cannabinoid_on	0	100	No	Yes	No	Yes	9	9
342	E1	E1	cannabinoid_on	0	100	Yes	Yes	Yes	Yes	4	4
343	3x26	4x60	cannabinoid_on	0	100	No	No	No	No	5	5
344	2x57	3x36	cannabinoid_on	0	100	No	Yes	Yes	Yes	6	6
345	5x63	5x67	cannabinoid_on	0	100	No	No	No	No	3	5
346	I3	I3	cannabinoid_on	0	100	No	Yes	No	Yes	3	3
347	1x50	2x51	cannabinoid_on	0	50	No	Yes	No	Yes	9	7
348	5x60	5x63	cannabinoid_on	0	50	No	Yes	No	No	5	3
349	3x30	3x33	cannabinoid_on	0	75	No	No	No	Yes	6	4
350	5x61	6x37	cannabinoid_on	0	36.6667	No	No	No	No	9	8
351	2x50	3x39	cannabinoid_on	0	50	No	Yes	No	No	9	9
352	7x27	E3	cannabinoid_on	0	50	No	No	No	Yes	2	1
353	6x30	6x31	cannabinoid_on	0	58.3333	Yes	Yes	No	No	7	5
354	2x53	3x36	cannabinoid_on	0	60	No	No	Yes	Yes	8	6
355	1x38	1x42	cannabinoid_on	0	60	No	No	No	Yes	5	6
356	7x51	7x55	cannabinoid_on	0	46.6667	No	No	No	No	6	6
357	4x56	5x42	cannabinoid_on	0	50	No	No	No	No	5	5
358	2x42	4x42	cannabinoid_on	0	45	Yes	No	No	No	8	7
359	4x39	I1x51	cannabinoid_on	0	35	No	Yes	No	No	3	3
360	5x62	6x34	cannabinoid_on	0	58.3333	No	No	No	No	6	8
361	1x57	2x40	cannabinoid_on	0	50	No	No	Yes	Yes	8	8
362	8x48	8x49	cannabinoid_on	0	50	No	No	No	No	4	6
363	5x69	6x29	cannabinoid_on	0	60	No	No	No	No	5	5
364	7x54	8x50	cannabinoid_on	0	20	No	No	No	No	8	8
365	8x60	8x61	cannabinoid_on	0	50	No	No	No	No	5	3
366	6x50	7x40	cannabinoid_on	0	45	No	No	No	No	9	8
367	1x50	2x47	cannabinoid_on	0	50	No	Yes	No	No	9	9
368	1x42	7x43	cannabinoid_on	0	50	No	Yes	No	No	6	4
369	2x41	4x42	cannabinoid_on	0	35	No	No	No	No	4	7
370	5x68	5x72	cannabinoid_on	0	50	No	No	No	No	7	0
371	2x40	2x43	cannabinoid_on	0	36.6667	Yes	Yes	No	No	8	8
372	1x43	1x46	cannabinoid_on	0	20	No	No	No	No	7	7
373	I1	I1x49	cannabinoid_on	0	50	No	No	No	No	7	6
374	5x68	6x29	cannabinoid_on	0	20	No	No	No	No	7	5
375	2x56	3x31	cannabinoid_on	0	60	No	No	No	No	4	4
376	2x44	2x47	cannabinoid_on	0	0	No	No	No	No	7	9
377	3x52	I2x53	cannabinoid_on	0	10	No	No	Yes	Yes	5	7
378	3x34	4x54	cannabinoid_on	0	26.6667	No	No	No	No	5	3
379	5x44	6x56	cannabinoid_on	0	20	No	No	No	No	4	5
380	6x32	6x35	cannabinoid_on	0	50	No	No	No	No	8	7
381	6x31	6x35	cannabinoid_on	0	50	No	No	No	No	5	7
382	5x65	6x33	cannabinoid_on	0	0	No	No	No	No	8	7
383	4x61	4x62	cannabinoid_on	0	16.6667	No	No	No	No	6	4
384	6x44	6x45	cannabinoid_on	0	18.3333	No	No	No	No	9	6
385	5x62	6x33	cannabinoid_on	0	0	No	No	No	No	6	7
386	1x56	8x57	cannabinoid_on	0	25	No	No	No	No	8	6
387	6x29	6x33	cannabinoid_on	0	8.33333	No	No	No	No	5	7
388	6x56	6x60	cannabinoid_on	0	20	No	No	No	No	5	4
389	5x72	I3	cannabinoid_on	0	26.6667	No	No	No	Yes	0	3
390	1x58	I1x51	cannabinoid_on	0	26.6667	No	No	No	No	4	3
391	4x46	4x47	cannabinoid_on	0	10	No	No	No	No	8	4
392	4x41	4x44	cannabinoid_on	0	10	No	No	No	No	6	3
393	2x65	7x35	cannabinoid_on	0	0	No	Yes	No	No	4	4
394	1x41	1x45	cannabinoid_on	0	20	No	No	No	No	4	4
395	8x60	8x63	cannabinoid_on	0	8.33333	No	No	No	No	5	2
396	5x59	6x41	cannabinoid_on	0	10	No	No	No	No	3	7
397	5x73	I3	cannabinoid_on	0	10	No	No	No	Yes	0	3
398	1x44	1x45	cannabinoid_on	0	20	No	No	No	No	5	4
399	5x49	5x50	cannabinoid_on	0	0	No	No	No	Yes	4	7
400	5x48	6x52	cannabinoid_on	0	10	No	No	No	No	4	6
401	4x48	4x51	cannabinoid_on	0	10	No	No	No	No	3	3
402	1x52	8x54	cannabinoid_on	0	10	No	No	No	No	7	6
403	8x56	8x57	cannabinoid_on	0	10	No	No	No	No	5	6
404	1x40	2x62	cannabinoid_on	0	0	No	No	No	No	5	5
405	6x46	6x47	cannabinoid_on	0	0	No	No	No	No	5	8
406	5x67	5x71	cannabinoid_on	0	0	No	No	No	No	5	3
407	5x52	5x53	cannabinoid_on	0	10	No	No	No	No	3	5
408	4x52	4x55	cannabinoid_on	0	8.33333	No	No	No	No	4	3
409	6x27	6x30	cannabinoid_on	0	10	No	No	Yes	Yes	0	7
410	5x75	5x76	cannabinoid_on	0	0	No	No	No	No	0	0
411	7x33	7x36	cannabinoid_on	0	10	No	No	No	Yes	3	4
412	1x34	7x36	cannabinoid_on	0	0	No	No	No	Yes	5	4
413	5x76	I3	cannabinoid_on	0	0	No	No	No	Yes	0	3
414	5x70	5x74	cannabinoid_on	0	0	No	No	No	No	5	0
415	8x55	8x58	cannabinoid_on	0	0	No	No	No	No	4	6

Orange: nodes, hubs and links specific of cannabinoid_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of cannabinoid_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	cannabinoid_off Avg Int. Strength	cannabinoid_on Avg Int. Strength	cannabinoid_off Num Of Links	cannabinoid_on Num Of Links	ConSurf
1	1x49	cannabinoid_off	0	0	4	3	8
2	2x42	cannabinoid_off	25	0	4	3	8
3	3x50	cannabinoid_off	100	0	7	3	9
4	4x58	cannabinoid_off	0	0	5	1	4
5	5x64	cannabinoid_off	0	0	4	2	6
6	6x59	cannabinoid_off	0	0	4	2	3
7	7x30	cannabinoid_off	0	0	4	1	3
8	7x45	cannabinoid_off	50	0	5	3	9
9	7x49	cannabinoid_off	25	30	4	3	9
10	7x56	cannabinoid_off	0	0	4	2	7
11	Lig	Shared	100	100	14	14	0
12	NT	Shared	100	100	17	10	5
13	2x40	Shared	100	100	5	7	8
14	2x61	Shared	75	65	4	4	6
15	2x66	Shared	0	0	4	4	4
16	E1	Shared	100	100	5	8	4
17	3x36	Shared	50	41.6667	4	5	6
18	3x44	Shared	0	0	4	4	6
19	3x49	Shared	50	50	4	4	9
20	I2x53	Shared	100	0	5	4	7
21	4x50	Shared	50	45	5	5	9
22	E2	Shared	100	100	22	20	5
23	5x43	Shared	100	80	5	6	5
24	5x58	Shared	75	100	6	6	9
25	6x30	Shared	0	0	4	4	7
26	6x48	Shared	100	90	5	5	8
27	1x42	cannabinoid_on	0	8.33333	1	4	6
28	1x50	cannabinoid_on	0	0	2	4	9
29	2x46	cannabinoid_on	0	46.6667	3	4	9
30	2x50	cannabinoid_on	50	50	3	5	9
31	2x51	cannabinoid_on	0	0	2	4	7
32	2x57	cannabinoid_on	50	90	3	6	6
33	2x64	cannabinoid_on	0	45	3	5	3
34	2x65	cannabinoid_on	0	0	2	5	4
35	3x25	cannabinoid_on	0	16.6667	2	4	9
36	3x33	cannabinoid_on	0	0	3	4	4
37	4x39	cannabinoid_on	0	0	3	4	3
38	5x39	cannabinoid_on	0	20	3	4	7
39	5x50	cannabinoid_on	0	0	3	4	7
40	5x51	cannabinoid_on	0	50	2	4	7
41	5x60	cannabinoid_on	0	50	3	5	5
42	I3	cannabinoid_on	0	0	3	5	3
43	E3	cannabinoid_on	0	40	2	4	1
44	7x34	cannabinoid_on	50	40	3	4	4
45	7x36	cannabinoid_on	0	0	1	4	4
46	7x47	cannabinoid_on	0	0	3	4	6
47	7x52	cannabinoid_on	0	30	1	4	9
48	7x53	cannabinoid_on	25	71.6667	3	6	9

Orange: nodes, hubs and links specific of cannabinoid_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of cannabinoid_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	cannabinoid_off Recurrence	cannabinoid_on Recurrence	cannabinoid_off Hub1?	cannabinoid_on Hub1?	cannabinoid_off Hub2?	cannabinoid_on Hub2?	ConSurf1	ConSurf2
1	3x33	Lig	cannabinoid_off	10.1432	7.58948	No	Yes	Yes	Yes	4	0
2	6x48	Lig	cannabinoid_off	79.2053	0	Yes	Yes	Yes	Yes	8	0
3	6x51	Lig	cannabinoid_off	12.8853	0	No	No	Yes	Yes	6	0
4	2x39	2x40	cannabinoid_off	27.706	0	No	No	Yes	Yes	8	8
5	2x39	3x50	cannabinoid_off	28.6574	0	No	No	Yes	No	8	9
6	3x49	3x50	cannabinoid_off	67.7657	0	Yes	Yes	Yes	No	9	9
7	2x42	2x43	cannabinoid_off	82.5631	0	Yes	No	No	No	8	8
8	2x43	7x53	cannabinoid_off	83.132	0	No	No	No	Yes	8	9
9	7x49	7x53	cannabinoid_off	96.3811	0	Yes	No	No	Yes	9	9
10	2x46	7x53	cannabinoid_off	37.6207	0	No	Yes	No	Yes	9	9
11	2x45	4x46	cannabinoid_off	17.1012	2.44071	No	No	No	No	9	8
12	2x41	4x46	cannabinoid_off	13.4636	0	No	No	No	No	4	8
13	2x48	4x50	cannabinoid_off	10.8474	0	No	No	Yes	Yes	7	9
14	3x36	3x40	cannabinoid_off	18.7007	0	Yes	Yes	No	No	6	8
15	3x50	6x30	cannabinoid_off	43.021	0	Yes	No	Yes	Yes	9	7
16	6x30	I3	cannabinoid_off	29.2823	0	Yes	Yes	No	Yes	7	3
17	5x68	I3	cannabinoid_off	25.3649	0	No	No	No	Yes	7	3
18	3x54	5x68	cannabinoid_off	19.9272	0	No	No	No	No	9	7
19	3x51	5x60	cannabinoid_off	10.9266	3.0249	No	No	No	Yes	8	5
20	7x34	E2	cannabinoid_off	16.0099	2.3219	No	Yes	Yes	Yes	4	5
21	6x51	7x34	cannabinoid_off	20.7527	1.3169	No	No	No	Yes	6	4
22	2x42	6x37	cannabinoid_off	12.918	0	Yes	No	No	No	8	8
23	6x26	6x30	cannabinoid_off	16.6908	0	No	No	Yes	Yes	0	7
24	6x26	6x29	cannabinoid_off	15.6368	0	No	No	No	No	0	5
25	6x29	6x32	cannabinoid_off	14.345	0	No	No	No	No	5	8
26	6x54	7x34	cannabinoid_off	34.3002	8.54993	No	No	No	Yes	4	4
27	6x54	7x37	cannabinoid_off	11.5795	7.14887	No	No	No	No	4	4
28	6x54	7x30	cannabinoid_off	20.1698	0	No	No	Yes	No	4	3
29	Lig	NT	cannabinoid_off	21.5035	0	Yes	Yes	Yes	Yes	0	5
30	6x48	7x41	cannabinoid_off	10.1105	0.767365	Yes	Yes	No	No	8	7
31	E2	Lig	Shared	39.1177	34.4126	Yes	Yes	Yes	Yes	5	0
32	1x49	7x50	Shared	14.7694	13.5403	Yes	No	No	No	8	9
33	1x50	7x50	Shared	16.0565	13.6591	No	Yes	No	No	9	9
34	1x50	2x50	Shared	17.3343	24.5309	No	Yes	No	Yes	9	9
35	2x50	7x49	Shared	19.862	10.2431	No	Yes	Yes	No	9	9
36	7x45	7x49	Shared	100	99.4059	Yes	No	Yes	No	9	9
37	6x48	7x45	Shared	99.8648	100	Yes	Yes	Yes	No	8	9
38	1x49	7x47	Shared	10.852	13.5254	Yes	No	No	Yes	8	6
39	1x60	I1x50	Shared	16.784	18.0653	No	No	No	No	7	8
40	2x40	I1x50	Shared	20.6175	19.4515	Yes	Yes	No	No	8	8
41	2x42	3x49	Shared	75.1061	47.5568	Yes	No	Yes	Yes	8	9
42	2x46	3x42	Shared	35.3822	73.3155	No	Yes	No	No	9	8
43	2x45	3x42	Shared	34.2443	72.4046	No	No	No	No	9	8
44	2x45	4x50	Shared	17.1105	69.0381	No	No	Yes	Yes	9	9
45	3x40	5x50	Shared	15.0772	19.803	No	No	No	Yes	8	7
46	3x54	5x64	Shared	18.7287	20.7783	No	No	Yes	No	9	6
47	5x60	5x64	Shared	13.5662	19.3623	No	Yes	Yes	No	5	6
48	5x58	6x37	Shared	11.8827	50.3936	Yes	Yes	No	No	9	8
49	3x36	6x48	Shared	11.4676	91.4798	Yes	Yes	Yes	Yes	6	8
50	E2	NT	cannabinoid_on	6.68283	10.2084	Yes	Yes	Yes	Yes	5	5
51	1x35	7x36	cannabinoid_on	2.36441	16.1444	No	No	No	Yes	5	4
52	1x35	2x61	cannabinoid_on	4.72882	18.4118	No	No	Yes	Yes	5	6
53	2x61	Lig	cannabinoid_on	0	10.3718	Yes	Yes	Yes	Yes	6	0
54	2x64	Lig	cannabinoid_on	6.2398	17.6147	No	Yes	Yes	Yes	3	0
55	2x64	E1	cannabinoid_on	0	10.2876	No	Yes	Yes	Yes	3	4
56	1x42	7x42	cannabinoid_on	0	14.0452	No	Yes	No	No	6	6
57	2x57	7x42	cannabinoid_on	7.59688	15.1988	No	Yes	No	No	6	6
58	1x42	7x47	cannabinoid_on	1.38507	14.0205	No	Yes	No	Yes	6	6
59	3x36	Lig	cannabinoid_on	9.44364	77.5781	Yes	Yes	Yes	Yes	6	0
60	2x37	2x40	cannabinoid_on	1.38973	27.9667	No	No	Yes	Yes	6	8
61	2x37	2x38	cannabinoid_on	0	36.9375	No	No	No	No	6	5
62	2x38	I2x57	cannabinoid_on	0	38.1653	No	No	No	No	5	6
63	3x49	I2x57	cannabinoid_on	4.0526	39.4376	Yes	Yes	No	No	9	6
64	2x42	3x45	cannabinoid_on	0	62.7506	Yes	No	No	No	8	6
65	3x45	4x49	cannabinoid_on	0.205195	64.7606	No	No	No	No	6	6
66	4x49	4x50	cannabinoid_on	2.74215	66.731	No	No	Yes	Yes	6	9
67	2x46	7x49	cannabinoid_on	0	89.0836	No	Yes	Yes	No	9	9
68	2x46	3x43	cannabinoid_on	0	65.6122	No	Yes	No	No	9	8
69	5x43	Lig	cannabinoid_on	5.92734	10.1936	Yes	Yes	Yes	Yes	5	0
70	3x40	6x48	cannabinoid_on	0	19.6049	No	No	Yes	Yes	8	8
71	5x51	6x48	cannabinoid_on	0	10.5055	No	Yes	Yes	Yes	7	8
72	5x43	5x47	cannabinoid_on	1.31978	10.5401	Yes	Yes	No	No	5	7
73	5x47	5x51	cannabinoid_on	0	10.4114	No	No	No	Yes	7	7
74	3x43	7x53	cannabinoid_on	0	64.5527	No	No	No	Yes	8	9
75	5x58	7x53	cannabinoid_on	0	54.0819	Yes	Yes	No	Yes	9	9
76	5x61	6x37	cannabinoid_on	0	23.3427	No	No	No	No	9	8
77	3x54	5x61	cannabinoid_on	0	21.9417	No	No	No	No	9	9
78	2x42	4x42	cannabinoid_on	0	18.9168	Yes	No	No	No	8	7
79	2x41	4x42	cannabinoid_on	0	17.5207	No	No	No	No	4	7
80	2x41	4x39	cannabinoid_on	9.52759	14.6987	No	No	No	Yes	4	3
81	5x46	5x50	cannabinoid_on	7.57823	10.0302	No	No	No	Yes	5	7
82	5x44	6x55	cannabinoid_on	0	14.773	No	No	No	No	4	6
83	5x43	6x55	cannabinoid_on	0	10.9807	Yes	Yes	No	No	5	6
84	5x62	6x37	cannabinoid_on	0	29.1104	No	No	No	No	6	8
85	5x62	6x33	cannabinoid_on	0	26.3676	No	No	No	No	6	7
86	6x29	6x33	cannabinoid_on	0	23.615	No	No	No	No	5	7
87	5x69	6x29	cannabinoid_on	0	14.5601	No	No	No	No	5	5
88	5x69	6x30	cannabinoid_on	0	13.3274	No	No	Yes	Yes	5	7
89	1x56	8x57	cannabinoid_on	0	11.1936	No	No	No	No	8	6
90	1x56	8x53	cannabinoid_on	6.67817	15.476	No	No	No	No	8	7
91	1x60	8x53	cannabinoid_on	8.03526	16.6691	No	No	No	No	7	7
92	2x57	3x36	cannabinoid_on	0	14.0849	No	Yes	Yes	Yes	6	6
93	2x46	2x50	cannabinoid_on	0	17.9514	No	Yes	No	Yes	9	9

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
2x57	Lig	Shared	11.4625	9.13483	1	1	1	0
2x64	Lig	Shared	3.415	10.3997	1	1	1	0
3x29	Lig	Shared	4.0325	6.01983	1	1	1	0
3x32	Lig	Shared	10.7725	4.56383	0	1	1	0
3x33	Lig	Shared	3.52	10.0843	1	1	1	0
3x36	Lig	Shared	5.125	4.53717	1	1	1	0
E2	Lig	Shared	16.825	27.2977	1	1	1	0
5x43	Lig	Shared	6.445	12.0593	1	1	1	0
6x48	Lig	cannabinoid_off	5.4275	0	1	1	1	0
6x51	Lig	cannabinoid_off	3.9725	0	1	0	1	0
7x38	Lig	Shared	10.2875	5.84367	0	1	1	0
7x41	Lig	cannabinoid_off	4.1525	0	1	1	1	0
NT	NT	Shared	35.72	10.486	1	1	1	1
E2	NT	Shared	25.2225	13.4383	1	1	1	1
2x64	NT	Shared	18.6725	8.572	1	1	1	1
3x25	NT	cannabinoid_off	9.7025	0	1	1	2	1
E1	NT	Shared	16.55	7.6745	1	1	2	1
7x28	NT	Shared	4.43	1.60033	0	0	2	1
7x31	NT	Shared	6.445	6.398	1	1	2	1
7x32	NT	Shared	5.685	4.15767	0	1	2	1
1x32	NT	Shared	6.845	3.7805	1	1	2	1
1x28	1x31	Shared	7.9025	4.58583	1	0	2	2
1x38	7x39	Shared	3.535	3.86333	0	0	2	1
1x39	2x61	cannabinoid_off	4.4075	0	0	0	2	1
1x39	7x39	Shared	3.9625	3.233	0	0	2	1
2x57	7x42	Shared	6.395	4.89233	1	1	1	2
2x61	2x65	Shared	14.42	10.4462	0	1	1	1
2x64	2x65	Shared	8.77	7.86083	1	1	1	1
3x28	E1	cannabinoid_off	11.06	0	1	0	2	2
3x22	E2	Shared	12.9875	8.038	1	1	2	1
3x25	E2	Shared	14.15	12.3987	1	1	2	1
3x26	E2	Shared	6.945	3.679	1	1	2	1
3x29	E2	Shared	10.5725	5.75	1	1	1	1
3x33	4x57	Shared	3.62	3.03567	1	1	1	2
3x33	5x43	Shared	7.8825	4.14333	1	1	1	1
3x36	6x48	Shared	16.7875	4.2435	1	1	1	1
3x37	5x43	Shared	4.8525	5.33667	0	0	2	1
3x40	5x51	Shared	4.2	3.43517	0	1	2	2
4x59	E2	Shared	5.975	3.7965	1	0	2	1
4x59	5x39	cannabinoid_off	4.1025	0	1	0	2	1
4x60	E2	cannabinoid_off	4.075	0	1	0	2	1
4x60	5x39	Shared	15.995	10.3145	1	0	2	1
E2	E2	Shared	53.7075	45.4325	1	1	1	1
5x36	E2	Shared	16.9075	14.1382	1	1	2	1
5x38	E2	Shared	11.295	5.46783	1	1	2	1
5x39	E2	Shared	13.935	9.40417	1	1	1	1
5x37	E2	Shared	7.7625	6.58267	1	1	2	1
6x58	E2	Shared	10.2525	10.4465	1	0	2	1
E2	E3	Shared	7.2375	10.3932	1	1	1	2
7x31	E2	Shared	6.1375	5.205	1	1	2	1
6x55	E2	Shared	6.26	3.46617	0	1	2	1
7x34	E2	Shared	14.425	11.222	1	1	1	1
5x40	E2	Shared	3.7175	7.3565	1	0	2	1
5x36	5x38	Shared	4.5	4.15067	1	1	2	2
5x43	5x47	Shared	8.34	10.3797	1	1	1	2
6x44	6x48	cannabinoid_off	3.9875	0	1	0	2	1
6x44	7x45	cannabinoid_off	4.46	0	1	0	2	2
6x48	7x41	Shared	11.1	5.39967	1	1	1	1
6x48	7x45	Shared	4.2375	6.13967	1	1	1	2
6x51	7x34	Shared	4.355	3.00317	1	0	1	1
6x51	7x41	cannabinoid_off	4.09	0	1	0	1	1
6x54	7x34	Shared	5.28	6.75983	0	0	2	1
6x58	E3	cannabinoid_off	4.2725	0	1	0	2	2
Lig	NT	cannabinoid_off	15.3225	0	1	1	0	1
7x39	Lig	cannabinoid_off	4.405	0	0	0	1	0
2x60	NT	cannabinoid_off	5.7075	0	1	0	1	1
3x28	NT	cannabinoid_off	4.655	0	1	0	2	1
2x57	NT	cannabinoid_off	3.42	0	1	1	1	1
1x31	NT	cannabinoid_off	4.6825	0	1	0	2	1
2x60	3x28	Shared	3.825	5.6865	1	0	1	2
1x28	NT	cannabinoid_off	3.505	0	1	0	2	1
3x36	3x40	cannabinoid_off	3.2775	0	1	1	1	2
5x42	E2	cannabinoid_off	3.24	0	0	0	2	1
5x43	5x44	cannabinoid_off	3.2125	0	1	1	1	2
1x40	2x61	cannabinoid_off	3.045	0	0	0	2	1
4x63	E2	Shared	2.6025	1.82517	0	0	2	1
3x36	6x52	cannabinoid_off	2.13	0	1	1	1	2
1x35	2x61	Shared	1.965	2.52317	0	0	2	1
2x56	3x32	Shared	1.9525	2.45033	0	0	2	1
7x35	NT	cannabinoid_off	1.4425	0	0	0	2	1
2x65	NT	cannabinoid_on	0	4.27067	0	1	1	1
2x57	2x61	cannabinoid_on	0	7.4835	1	1	1	1
2x57	3x32	cannabinoid_on	0	4.25933	1	1	1	1
2x57	7x38	cannabinoid_on	0	3.76367	1	1	1	1
2x60	Lig	cannabinoid_on	0	4.6045	1	0	1	0
2x61	Lig	cannabinoid_on	0	3.71233	0	1	1	0
2x64	E1	cannabinoid_on	0	3.7225	1	1	1	2
2x64	3x25	cannabinoid_on	0	3.143	1	1	1	2
2x65	Lig	cannabinoid_on	0	3.89833	0	1	1	0
3x25	E1	cannabinoid_on	0	2.97633	1	1	2	2
3x25	3x29	cannabinoid_on	0	4.967	1	1	2	1
3x36	7x41	cannabinoid_on	0	6.86767	1	1	1	1
3x40	6x48	cannabinoid_on	0	3.3715	0	1	2	1
5x39	5x43	cannabinoid_on	0	3.26183	1	1	1	1
5x39	Lig	cannabinoid_on	0	3.29683	1	1	1	0
5x43	6x55	cannabinoid_on	0	3.33433	1	1	1	2
5x44	6x52	cannabinoid_on	0	3.00833	0	0	2	2
5x44	6x55	cannabinoid_on	0	5.069	0	0	2	2
5x47	5x51	cannabinoid_on	0	3.9305	0	0	2	2
5x51	6x44	cannabinoid_on	0	4.34483	0	1	2	2
5x51	6x48	cannabinoid_on	0	5.49033	0	1	2	1
7x34	Lig	cannabinoid_on	0	4.30267	1	1	1	0
E1	E1	cannabinoid_on	0	3.82033	1	1	2	2
3x26	4x60	cannabinoid_on	0	3.722	1	1	2	2
2x57	3x36	cannabinoid_on	0	3.69867	1	1	1	1
3x30	3x33	cannabinoid_on	0	2.821	0	0	2	1
2x53	3x36	cannabinoid_on	0	2.56617	0	0	2	1
2x65	7x35	cannabinoid_on	0	1.1715	0	1	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	cannabinoid_off	cb2_off cb1_off
	cannabinoid_on	cb2_on cb1_on

Network Difference
Value	cannabinoid_off	cannabinoid_on
I_min	3.41	2.9015
Number of Linked Nodes	257	265
Number of Specific Nodes	3 (1.17%)	11 (4.15%)
Number of Shared Nodes	254 (98.83%)	254 (95.85%)
Number of Links	285	303
Number of Specific Links	112 (39.30%)	130 (42.90%)
Number of Shared Links	173 (60.70%)	173 (57.10%)
Number of Hubs	26	38
Number of Specific Hubs	10 (38.46%)	22 (57.89%)
Number of Shared Hubs	16 (61.54%)	16 (42.11%)
Average % Shared Neighbours (Jaccard)	46.59
Average % Shared Neighbours (Otsuka)	54.93
Average % Shared Neighbours (Overlap Coefficient)	63.32
Average % Shared Cliques (k3-6)	77.84
Graphlets Similarity	0.542834

Paths Difference
Value	cannabinoid_off	cannabinoid_on
Number Of Nodes in MetaPath	49	61
Specific Nodes in MetaPath	17 (34.69%)	29 (47.54%)
Shared Nodes in MetaPath	254 (98.83%)	254 (98.83%)
Number Of Links MetaPath	49	63
Specific Links in MetaPath	30 (61.22%)	44 (69.84%)
Shared Links in MetaPath	173 (60.70%)	173 (60.70%)
Number of Shortest Paths	39860	43199
Length Of Smallest Path	3	3
Average Path Length	12.646	13.7055
Length of Longest Path	28	35
Minimum Path Strength	0.5575	0.381417
Average Path Strength	5.60234	5.23671
Maximum Path Strength	21.065	20.7179
Minimum Path Correlation	0.7	0.704
Average Path Correlation	0.907772	0.913701
Maximum Path Correlation	0.99	0.99
Minimum % Of Corr. Nodes	4.34783	3.125
Average % Of Corr. Nodes	43.8252	45.7962
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	41.6145	42.0737
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download cannabinoid_off_on.zip<

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