psnGPCR

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Orange: nodes, hubs and links specific of cb1_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of cb1_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	cb1_off Int. Strength	cb1_on Int. Strength	cb1_off Hub1?	cb1_on Hub1?	cb1_off Hub2?	cb1_on Hub2?	ConSurf1	ConSurf2
1	Lig	NT.F102	cb1_off	100	0	Yes	Yes	Yes	No	0	5
2	Lig	NT.M103	cb1_off	100	0	Yes	Yes	Yes	No	0	4
3	Lig	NT.I105	cb1_off	100	0	Yes	Yes	No	No	0	3
4	1x39	Lig	cb1_off	100	0	Yes	Yes	Yes	Yes	7	0
5	6x51	Lig	cb1_off	100	0	Yes	Yes	Yes	Yes	7	0
6	7x38	Lig	cb1_off	100	0	No	No	Yes	Yes	6	0
7	7x39	Lig	cb1_off	100	0	No	No	Yes	Yes	5	0
8	7x41	Lig	cb1_off	100	0	No	No	Yes	Yes	7	0
9	E2.P269	NT.E100	cb1_off	100	0	No	No	No	No	3	4
10	E2.H270	NT.E100	cb1_off	100	0	Yes	Yes	No	No	3	4
11	2x64	NT.N101	cb1_off	100	0	No	Yes	Yes	No	4	6
12	E1.K183	NT.N101	cb1_off	100	0	No	No	Yes	No	6	6
13	E1.D184	NT.N101	cb1_off	100	0	No	No	Yes	No	2	6
14	NT.F102	NT.M103	cb1_off	100	0	Yes	No	Yes	No	5	4
15	2x60	NT.F102	cb1_off	100	0	No	No	Yes	No	4	5
16	3x25	NT.F102	cb1_off	100	0	Yes	No	Yes	No	9	5
17	3x28	NT.F102	cb1_off	100	0	Yes	No	Yes	No	6	5
18	2x57	NT.M103	cb1_off	100	0	Yes	Yes	Yes	No	7	4
19	2x60	NT.M103	cb1_off	100	0	No	No	Yes	No	4	4
20	2x61	NT.M103	cb1_off	100	0	Yes	Yes	Yes	No	5	4
21	2x64	NT.D104	cb1_off	100	0	No	Yes	No	No	4	6
22	NT.E106	NT.I105	cb1_off	100	0	No	No	No	No	4	3
23	NT.E106	NT.L111	cb1_off	100	0	No	No	Yes	No	4	4
24	7x31	NT.F108	cb1_off	100	0	No	No	Yes	No	2	5
25	7x34	NT.F108	cb1_off	100	0	Yes	Yes	Yes	No	4	5
26	7x32	NT.M109	cb1_off	100	0	No	No	No	No	1	3
27	1x31	NT.L111	cb1_off	100	0	No	No	Yes	No	2	4
28	1x39	2x57	cb1_off	100	0	Yes	Yes	Yes	Yes	7	7
29	1x39	2x61	cb1_off	100	0	Yes	Yes	Yes	Yes	7	5
30	1x40	2x61	cb1_off	100	0	No	No	Yes	Yes	3	5
31	1x45	1x49	cb1_off	100	0	No	No	Yes	No	4	8
32	1x46	1x49	cb1_off	100	0	Yes	Yes	Yes	No	7	8
33	1x46	7x42	cb1_off	100	0	Yes	Yes	No	No	7	7
34	1x47	2x55	cb1_off	100	0	No	No	No	No	6	4
35	1x49	7x47	cb1_off	100	0	Yes	No	Yes	No	8	7
36	1x51	2x51	cb1_off	100	0	No	No	No	No	3	7
37	1x53	7x50	cb1_off	100	0	No	No	No	No	9	9
38	1x53	7x53	cb1_off	100	0	No	No	Yes	Yes	9	9
39	1x57	I1x50	cb1_off	100	0	No	No	No	No	7	9
40	2x37	2x39	cb1_off	100	0	Yes	No	No	No	5	8
41	2x38	I2x57	cb1_off	100	0	No	No	Yes	No	5	6
42	2x39	2x40	cb1_off	100	0	No	No	Yes	Yes	8	9
43	2x41	4x46	cb1_off	100	0	No	No	No	No	3	8
44	2x42	2x43	cb1_off	100	0	Yes	No	No	No	8	8
45	2x42	2x46	cb1_off	100	0	Yes	No	Yes	Yes	8	9
46	2x42	3x46	cb1_off	100	0	Yes	No	No	No	8	9
47	2x42	6x37	cb1_off	100	0	Yes	No	No	Yes	8	8
48	2x43	7x53	cb1_off	100	0	No	No	Yes	Yes	8	9
49	2x46	7x53	cb1_off	100	0	Yes	Yes	Yes	Yes	9	9
50	2x48	4x50	cb1_off	100	0	No	No	Yes	Yes	6	9
51	2x59	2x63	cb1_off	100	0	No	No	No	No	7	3
52	2x63	3x28	cb1_off	100	0	No	No	Yes	No	3	6
53	3x24	E1.D184	cb1_off	100	0	No	No	No	No	5	2
54	3x28	E1.D184	cb1_off	100	0	Yes	No	No	No	6	2
55	3x25	3x26	cb1_off	100	0	Yes	No	No	No	9	5
56	3x36	3x40	cb1_off	100	0	Yes	Yes	No	No	7	7
57	3x36	5x43	cb1_off	100	0	Yes	Yes	Yes	Yes	7	6
58	3x36	5x47	cb1_off	100	0	Yes	Yes	No	No	7	8
59	3x36	6x44	cb1_off	100	0	Yes	Yes	No	No	7	9
60	3x36	6x48	cb1_off	100	0	Yes	Yes	Yes	Yes	7	8
61	3x36	6x52	cb1_off	100	0	Yes	Yes	No	Yes	7	7
62	3x40	5x51	cb1_off	100	0	No	No	No	No	7	6
63	3x43	5x58	cb1_off	100	0	No	No	Yes	Yes	8	9
64	3x45	4x46	cb1_off	100	0	No	No	No	No	6	8
65	3x46	6x37	cb1_off	100	0	No	No	No	Yes	9	8
66	3x49	3x50	cb1_off	100	0	Yes	No	Yes	No	9	9
67	3x49	I2x57	cb1_off	100	0	Yes	No	Yes	No	9	6
68	3x50	3x53	cb1_off	100	0	Yes	No	No	No	9	8
69	3x50	I2x53	cb1_off	100	0	Yes	No	Yes	Yes	9	7
70	3x50	5x61	cb1_off	100	0	Yes	No	No	No	9	9
71	3x50	6x30	cb1_off	100	0	Yes	No	No	No	9	7
72	3x50	6x33	cb1_off	100	0	Yes	No	No	No	9	8
73	3x52	I2x53	cb1_off	100	0	No	No	Yes	Yes	5	7
74	3x53	6x30	cb1_off	100	0	No	No	No	No	8	7
75	3x56	I2x52	cb1_off	100	0	Yes	No	No	No	5	5
76	3x56	I2x56	cb1_off	100	0	Yes	No	No	No	5	4
77	4x63	E2.K259	cb1_off	100	0	No	No	No	No	5	4
78	5x36	E2.W255	cb1_off	100	0	Yes	No	Yes	Yes	5	5
79	5x42	E2.W255	cb1_off	100	0	No	No	Yes	Yes	6	5
80	E2.C257	E2.E258	cb1_off	100	0	No	No	Yes	No	9	1
81	E2.E258	E2.H270	cb1_off	100	0	Yes	No	Yes	Yes	1	3
82	6x58	E2.S265	cb1_off	100	0	Yes	No	No	No	4	4
83	6x55	E2.I267	cb1_off	100	0	No	Yes	Yes	No	6	4
84	6x55	E2.F268	cb1_off	100	0	No	Yes	Yes	Yes	6	5
85	5x37	6x59	cb1_off	100	0	No	No	Yes	No	3	4
86	5x41	6x59	cb1_off	100	0	No	No	Yes	No	4	4
87	5x43	5x44	cb1_off	100	0	Yes	Yes	No	No	6	5
88	5x54	5x58	cb1_off	100	0	No	No	Yes	Yes	8	9
89	5x59	5x63	cb1_off	100	0	No	No	No	No	3	3
90	6x25	6x28	cb1_off	100	0	No	No	No	No	3	4
91	6x26	6x29	cb1_off	100	0	No	No	No	No	5	6
92	6x26	6x30	cb1_off	100	0	No	No	No	No	5	7
93	6x40	7x49	cb1_off	100	0	No	No	Yes	Yes	8	9
94	6x41	6x45	cb1_off	100	0	No	No	No	No	8	6
95	6x44	6x48	cb1_off	100	0	No	No	Yes	Yes	9	8
96	6x44	7x45	cb1_off	100	0	No	No	Yes	No	9	9
97	6x48	7x41	cb1_off	100	0	Yes	Yes	No	No	8	7
98	6x50	7x37	cb1_off	100	0	No	No	No	No	9	5
99	6x54	7x30	cb1_off	100	0	No	No	Yes	No	4	3
100	6x58	E3.M371	cb1_off	100	0	Yes	No	No	No	4	1
101	7x31	E3.M371	cb1_off	100	0	No	No	No	No	2	1
102	7x27	7x30	cb1_off	100	0	No	No	Yes	No	1	3
103	7x49	7x53	cb1_off	100	0	Yes	Yes	Yes	Yes	9	9
104	1x28	NT.M109	cb1_off	100	0	Yes	No	No	No	6	3
105	1x28	1x32	cb1_off	100	0	Yes	No	No	No	6	4
106	5x63	5x64	cb1_off	100	0	No	No	Yes	Yes	3	5
107	5x67	5x68	cb1_off	100	0	No	No	No	No	0	0
108	6x57	7x30	cb1_off	100	0	No	No	Yes	No	4	3
109	1x53	2x47	cb1_off	50	0	No	No	No	No	9	9
110	5x66	6x31	cb1_off	50	0	No	No	Yes	No	0	5
111	6x42	6x46	cb1_off	0	0	No	No	No	No	6	5
112	1x43	2x57	cb1_off	0	0	No	No	Yes	Yes	6	7
113	2x46	3x39	cb1_off	0	0	Yes	Yes	No	No	9	9
114	2x51	2x55	cb1_off	0	0	No	No	No	No	7	4
115	6x43	7x45	cb1_off	50	0	No	No	Yes	No	6	9
116	7x43	7x47	cb1_off	0	0	No	No	Yes	No	5	7
117	6x31	6x35	cb1_off	50	0	Yes	No	No	No	5	7
118	2x38	4x42	cb1_off	50	0	No	No	No	No	5	7
119	1x36	2x61	cb1_off	0	0	No	No	Yes	Yes	5	5
120	7x40	7x43	cb1_off	0	0	No	No	No	No	7	5
121	5x36	E2.L260	cb1_off	50	0	Yes	No	No	No	5	3
122	1x57	2x44	cb1_off	0	0	No	No	No	No	7	6
123	2x43	2x44	cb1_off	50	0	No	No	No	No	8	6
124	2x37	I1x49	cb1_off	50	0	Yes	No	No	No	5	5
125	5x62	5x66	cb1_off	50	0	No	No	No	No	6	0
126	NT.G99	NT.N101	cb1_off	50	0	No	No	Yes	No	0	6
127	5x58	6x38	cb1_off	50	0	Yes	Yes	No	No	9	6
128	6x56	6x57	cb1_off	50	0	No	No	No	No	6	4
129	5x65	6x31	cb1_off	0	0	No	No	Yes	No	8	5
130	7x47	7x48	cb1_off	50	0	Yes	No	No	No	7	6
131	7x30	7x33	cb1_off	0	0	Yes	No	No	No	3	4
132	4x44	4x48	cb1_off	0	0	No	No	No	No	3	3
133	4x55	4x59	cb1_off	0	0	No	No	No	No	3	5
134	5x62	6x38	cb1_off	0	0	No	No	No	No	6	6
135	NT.L111	NT.V110	cb1_off	50	0	Yes	No	No	No	4	3
136	1x44	1x48	cb1_off	0	0	No	No	No	No	5	3
137	1x35	NT.L111	cb1_off	50	0	No	No	Yes	No	5	4
138	E1.F180	E1.R182	cb1_off	50	0	No	No	No	No	4	4
139	2x53	Lig	cb1_off	0	0	No	No	Yes	Yes	8	0
140	8x52	8x56	cb1_off	50	0	No	No	No	No	4	3
141	7x35	NT.F108	cb1_off	50	0	No	No	Yes	No	4	5
142	5x53	5x57	cb1_off	50	0	No	No	No	No	6	7
143	5x49	5x53	cb1_off	50	0	No	No	No	No	6	6
144	2x57	2x58	cb1_off	0	0	Yes	Yes	No	No	7	7
145	3x30	4x57	cb1_off	0	0	No	No	No	No	6	7
146	3x31	3x34	cb1_off	0	0	No	No	No	No	4	5
147	7x36	NT.M109	cb1_off	50	0	No	No	No	No	4	3
148	7x28	NT.F108	cb1_off	50	0	No	No	Yes	No	3	5
149	4x50	4x54	cb1_off	0	0	Yes	Yes	No	No	9	4
150	5x44	5x45	cb1_off	0	0	No	No	No	No	5	3
151	4x43	4x47	cb1_off	0	0	No	No	No	No	1	4
152	6x49	6x52	cb1_off	50	0	No	No	No	Yes	5	7
153	1x29	1x33	cb1_off	50	0	No	No	No	No	2	5
154	6x38	6x42	cb1_off	0	0	No	No	No	No	6	6
155	4x54	4x58	cb1_off	0	0	No	No	No	No	4	5
156	6x60	6x61	cb1_off	0	0	No	No	No	No	5	3
157	NT.C107	NT.F108	cb1_off	0	0	No	No	Yes	No	2	5
158	I1.C149	I1x51	cb1_off	0	0	No	No	No	No	7	8
159	4x39	I1.C149	cb1_off	0	0	No	No	No	No	1	7
160	1x54	1x58	cb1_off	0	0	No	No	No	No	7	4
161	6x24	6x27	cb1_off	0	0	No	No	No	No	0	4
162	5x69	6x27	cb1_off	0	0	No	No	No	No	0	4
163	6x61	E3.K370	cb1_off	0	0	No	No	No	Yes	3	1
164	1x55	8x57	cb1_off	0	0	No	No	No	No	4	5
165	6x27	6x31	cb1_off	0	0	No	No	Yes	No	4	5
166	1x44	2x58	cb1_off	0	0	No	No	No	No	5	7
167	1x56	8x57	cb1_off	0	0	Yes	No	No	No	8	5
168	4x51	4x52	cb1_off	0	0	No	No	No	No	4	5
169	1x33	1x37	cb1_off	0	0	No	No	No	No	5	4
170	1x52	1x56	cb1_off	0	0	No	No	Yes	No	7	8
171	I2x51	I2x54	cb1_off	0	0	No	No	No	No	7	4
172	1x59	8x56	cb1_off	0	0	No	No	No	No	5	3
173	8x48	8x49	cb1_off	0	0	No	No	No	No	5	6
174	8x54	8x58	cb1_off	0	0	No	No	No	No	7	5
175	2x57	Lig	Shared	100	100	Yes	Yes	Yes	Yes	7	0
176	3x32	Lig	Shared	100	100	No	No	Yes	Yes	7	0
177	E2.F268	Lig	Shared	100	100	Yes	Yes	Yes	Yes	5	0
178	1x28	1x29	Shared	100	100	Yes	No	No	No	6	2
179	1x28	1x31	Shared	100	100	Yes	No	No	No	6	2
180	1x46	2x54	Shared	100	100	Yes	Yes	No	No	7	7
181	1x46	7x47	Shared	100	100	Yes	Yes	Yes	No	7	7
182	1x47	2x54	Shared	100	50	No	No	No	No	6	7
183	1x49	7x50	Shared	100	100	Yes	No	No	No	8	9
184	1x50	2x50	Shared	100	100	No	No	No	Yes	9	9
185	1x50	7x50	Shared	100	100	No	No	No	No	9	9
186	1x54	2x48	Shared	100	100	No	No	No	No	7	6
187	1x59	8x57	Shared	100	100	No	No	No	No	5	5
188	1x60	I1x50	Shared	100	100	No	Yes	No	No	6	9
189	1x60	8x53	Shared	100	50	No	Yes	No	No	6	7
190	I1x48	I1x51	Shared	100	100	No	No	No	No	6	8
191	2x40	I1x50	Shared	100	100	Yes	Yes	No	No	9	9
192	2x37	2x40	Shared	100	100	Yes	No	Yes	Yes	5	9
193	2x37	8x49	Shared	100	100	Yes	No	No	No	5	6
194	2x40	8x47	Shared	100	100	Yes	Yes	No	No	9	8
195	2x40	8x49	Shared	100	100	Yes	Yes	No	No	9	6
196	2x41	4x43	Shared	100	0	No	No	No	No	3	1
197	2x45	3x42	Shared	100	100	No	No	No	No	9	8
198	2x45	4x46	Shared	100	100	No	No	No	No	9	8
199	2x45	4x50	Shared	100	100	No	No	Yes	Yes	9	9
200	2x46	3x42	Shared	100	100	Yes	Yes	No	No	9	8
201	2x50	7x46	Shared	100	100	No	Yes	No	No	9	9
202	2x50	7x49	Shared	100	100	No	Yes	Yes	Yes	9	9
203	2x57	7x42	Shared	100	100	Yes	Yes	No	No	7	7
204	2x59	3x28	Shared	100	50	No	No	Yes	No	7	6
205	2x60	3x28	Shared	100	100	No	No	Yes	No	4	6
206	2x61	2x65	Shared	100	100	Yes	Yes	No	Yes	5	4
207	2x62	2x66	Shared	100	100	No	No	No	No	5	4
208	2x63	E1.R182	Shared	100	100	No	No	No	No	3	4
209	2x64	2x65	Shared	100	100	No	Yes	No	Yes	4	4
210	2x66	E1.F180	Shared	100	100	No	No	No	No	4	4
211	3x21	3x24	Shared	100	0	No	No	No	No	7	5
212	3x22	3x23	Shared	100	100	No	Yes	No	No	3	1
213	3x22	E2.E258	Shared	100	100	No	Yes	Yes	No	3	1
214	3x22	E2.H270	Shared	100	100	No	Yes	Yes	Yes	3	3
215	3x25	E2.P269	Shared	100	100	Yes	No	No	No	9	3
216	3x25	E2.H270	Shared	100	100	Yes	No	Yes	Yes	9	3
217	3x26	4x61	Shared	100	100	No	No	No	No	5	5
218	3x26	E2.N256	Shared	100	100	No	No	No	Yes	5	6
219	3x29	E2.F268	Shared	100	100	No	No	Yes	Yes	4	5
220	3x29	E2.I271	Shared	100	100	No	No	No	Yes	4	3
221	3x33	5x43	Shared	100	100	No	Yes	Yes	Yes	6	6
222	3x37	5x43	Shared	100	100	No	No	Yes	Yes	6	6
223	3x38	4x50	Shared	100	100	No	No	Yes	Yes	7	9
224	3x40	5x50	Shared	100	50	No	No	No	No	7	8
225	3x41	4x49	Shared	100	100	No	No	No	No	5	6
226	3x44	3x48	Shared	100	100	No	No	No	No	7	7
227	3x44	5x50	Shared	100	100	No	No	No	No	7	8
228	3x45	4x49	Shared	100	50	No	No	No	No	6	6
229	3x47	5x58	Shared	100	100	No	No	Yes	Yes	8	9
230	3x49	I2x53	Shared	100	100	Yes	No	Yes	Yes	9	7
231	3x51	3x55	Shared	100	100	No	No	No	No	8	6
232	3x51	5x60	Shared	100	100	No	No	No	Yes	8	4
233	3x52	I2x56	Shared	100	50	No	No	No	No	5	4
234	3x52	I2x57	Shared	100	50	No	No	Yes	No	5	6
235	3x53	I2x53	Shared	100	100	No	No	Yes	Yes	8	7
236	3x55	3x56	Shared	100	100	No	No	Yes	No	6	5
237	I2x52	I2x55	Shared	100	50	No	No	No	No	5	4
238	I2x53	I2x57	Shared	100	100	Yes	Yes	Yes	No	7	6
239	4x38	4x40	Shared	100	100	No	No	No	No	8	4
240	4x38	4x41	Shared	100	50	No	No	No	No	8	5
241	4x49	4x50	Shared	100	50	No	No	Yes	Yes	6	9
242	4x58	4x62	Shared	100	50	No	No	No	No	5	5
243	4x59	E2.W255	Shared	100	100	No	No	Yes	Yes	5	5
244	4x60	5x39	Shared	100	100	No	No	No	Yes	6	7
245	5x39	E2.W255	Shared	100	100	No	Yes	Yes	Yes	7	5
246	E2.E258	E2.N256	Shared	100	100	Yes	No	No	Yes	1	6
247	E2.K259	E2.N256	Shared	100	100	No	No	No	Yes	4	6
248	E2.C257	E2.C264	Shared	100	100	No	No	No	No	9	9
249	5x36	E2.S262	Shared	100	100	Yes	No	No	No	5	3
250	5x37	E2.V263	Shared	100	100	No	No	No	No	3	4
251	E2.I271	E2.S265	Shared	100	0	No	Yes	No	No	3	4
252	6x58	E2.D266	Shared	100	100	Yes	No	No	No	4	4
253	E2.F268	E2.I267	Shared	100	100	Yes	Yes	Yes	No	5	4
254	6x58	E2.I267	Shared	100	100	Yes	No	Yes	No	4	4
255	7x34	E2.I267	Shared	100	100	Yes	Yes	Yes	No	4	4
256	E2.H270	E2.P269	Shared	100	100	Yes	Yes	No	No	3	3
257	5x40	E2.I271	Shared	100	100	No	No	No	Yes	5	3
258	5x36	5x38	Shared	100	100	Yes	No	No	No	5	5
259	5x42	5x46	Shared	100	100	No	No	No	No	6	6
260	5x43	5x47	Shared	100	100	Yes	Yes	No	No	6	8
261	5x55	6x41	Shared	100	100	No	No	No	No	5	8
262	5x58	6x37	Shared	100	100	Yes	Yes	No	Yes	9	8
263	5x58	6x41	Shared	100	100	Yes	Yes	No	No	9	8
264	5x60	5x64	Shared	100	100	No	Yes	Yes	Yes	4	5
265	6x32	7x56	Shared	100	50	No	No	No	Yes	7	7
266	6x36	7x56	Shared	100	100	No	No	No	Yes	8	7
267	6x39	7x52	Shared	100	50	No	No	No	Yes	7	9
268	6x40	7x52	Shared	100	100	No	No	No	Yes	8	9
269	6x47	7x45	Shared	100	100	No	No	Yes	No	8	9
270	6x48	7x45	Shared	100	100	Yes	Yes	Yes	No	8	9
271	6x49	6x50	Shared	100	100	No	No	No	No	5	9
272	6x51	6x55	Shared	100	100	Yes	Yes	No	Yes	7	6
273	6x51	7x34	Shared	100	100	Yes	Yes	Yes	Yes	7	4
274	6x51	7x41	Shared	100	100	Yes	Yes	No	No	7	7
275	6x54	7x34	Shared	100	100	No	No	Yes	Yes	4	4
276	6x59	6x60	Shared	100	100	Yes	No	No	No	4	5
277	7x45	7x49	Shared	100	100	Yes	No	Yes	Yes	9	9
278	8x47	8x50	Shared	100	100	No	No	No	Yes	8	8
279	8x48	8x51	Shared	100	50	No	No	No	No	5	8
280	8x51	8x55	Shared	100	50	No	No	No	No	8	5
281	3x54	5x64	Shared	100	100	No	No	Yes	Yes	9	5
282	3x37	4x53	Shared	50	100	No	No	No	No	6	8
283	1x56	8x54	Shared	50	50	Yes	No	No	No	8	7
284	3x45	4x45	Shared	50	0	No	No	No	No	6	5
285	4x56	5x42	Shared	50	100	No	No	No	No	5	6
286	2x52	3x35	Shared	0	0	No	No	No	No	6	7
287	1x56	8x50	Shared	50	50	Yes	No	No	Yes	8	8
288	5x40	6x59	Shared	50	50	No	No	Yes	No	5	4
289	1x42	7x47	Shared	50	100	No	No	Yes	No	6	7
290	2x41	4x39	Shared	50	100	No	No	No	No	3	1
291	5x45	5x48	Shared	50	0	No	No	No	No	3	5
292	1x49	7x51	Shared	0	100	Yes	No	No	No	8	6
293	3x30	3x33	Shared	50	50	No	No	No	Yes	6	6
294	3x44	5x53	Shared	50	100	No	No	No	No	7	6
295	2x49	4x50	Shared	0	0	No	No	Yes	Yes	8	9
296	6x35	7x56	Shared	50	0	No	No	No	Yes	7	7
297	5x39	5x43	Shared	50	100	No	Yes	Yes	Yes	7	6
298	2x56	3x32	Shared	0	50	No	No	No	No	5	7
299	1x28	1x30	Shared	50	100	Yes	No	No	No	6	5
300	2x39	3x49	Shared	50	100	No	No	Yes	No	8	9
301	7x29	7x32	Shared	50	0	No	No	No	No	4	1
302	3x30	3x31	Shared	0	0	No	No	No	No	6	4
303	5x66	5x70	Shared	50	50	No	No	No	No	0	0
304	5x56	5x60	Shared	50	100	No	No	No	Yes	4	4
305	2x53	3x35	Shared	50	100	No	No	No	No	8	7
306	5x62	6x34	Shared	50	100	No	No	No	No	6	7
307	1x38	1x39	Shared	0	50	No	No	Yes	Yes	5	7
308	4x52	4x56	Shared	0	0	No	No	No	No	5	5
309	3x56	I2x50	Shared	0	0	Yes	No	No	No	5	8
310	4x39	4x40	Shared	0	0	No	No	No	No	1	4
311	7x51	7x55	Shared	0	50	No	No	No	No	6	5
312	3x27	4x61	Shared	0	100	No	No	No	No	5	5
313	I2x53	I2x54	Shared	0	50	Yes	Yes	No	No	7	4
314	1x37	1x41	Shared	0	0	No	No	No	No	4	4
315	5x64	5x67	Shared	0	50	Yes	Yes	No	No	5	0
316	2x64	NT.F108	cb1_on	0	100	No	Yes	Yes	No	4	5
317	E2.P269	NT.F108	cb1_on	0	100	No	No	Yes	No	3	5
318	E1.H181	NT.M109	cb1_on	0	100	No	No	No	No	3	3
319	1x32	NT.L111	cb1_on	0	100	No	No	Yes	No	4	4
320	2x65	NT.L111	cb1_on	0	100	No	Yes	Yes	No	4	4
321	1x30	1x31	cb1_on	0	100	No	No	No	No	5	2
322	1x31	7x36	cb1_on	0	100	No	No	No	No	2	4
323	1x32	2x66	cb1_on	0	100	No	No	No	No	4	4
324	1x35	2x61	cb1_on	0	100	No	No	Yes	Yes	5	5
325	1x35	7x36	cb1_on	0	100	No	No	No	No	5	4
326	1x35	7x39	cb1_on	0	100	No	No	No	No	5	5
327	1x42	7x42	cb1_on	0	100	No	No	No	No	6	7
328	1x46	7x46	cb1_on	0	100	Yes	Yes	No	No	7	9
329	1x47	2x51	cb1_on	0	100	No	No	No	No	6	7
330	1x50	2x47	cb1_on	0	100	No	No	No	No	9	9
331	1x53	7x54	cb1_on	0	100	No	No	No	No	9	7
332	1x54	2x47	cb1_on	0	100	No	No	No	No	7	9
333	1x57	2x40	cb1_on	0	100	No	No	Yes	Yes	7	9
334	1x60	I1x49	cb1_on	0	100	No	Yes	No	No	6	5
335	8x50	I1x50	cb1_on	0	100	No	Yes	No	No	8	9
336	4x39	I1x51	cb1_on	0	100	No	No	No	No	1	8
337	2x40	8x50	cb1_on	0	100	Yes	Yes	No	Yes	9	8
338	2x42	3x45	cb1_on	0	100	Yes	No	No	No	8	6
339	2x42	3x49	cb1_on	0	100	Yes	No	Yes	No	8	9
340	2x43	3x46	cb1_on	0	100	No	No	No	No	8	9
341	2x46	2x50	cb1_on	0	100	Yes	Yes	No	Yes	9	9
342	2x46	3x43	cb1_on	0	100	Yes	Yes	No	No	9	8
343	2x46	7x49	cb1_on	0	100	Yes	Yes	Yes	Yes	9	9
344	2x50	3x39	cb1_on	0	100	No	Yes	No	No	9	9
345	2x54	2x55	cb1_on	0	100	No	No	No	No	7	4
346	2x57	2x61	cb1_on	0	100	Yes	Yes	Yes	Yes	7	5
347	2x57	7x38	cb1_on	0	100	Yes	Yes	No	No	7	6
348	2x60	Lig	cb1_on	0	100	No	No	Yes	Yes	4	0
349	2x61	7x38	cb1_on	0	100	Yes	Yes	No	No	5	6
350	2x61	7x39	cb1_on	0	100	Yes	Yes	No	No	5	5
351	2x61	Lig	cb1_on	0	100	Yes	Yes	Yes	Yes	5	0
352	2x64	E1.H181	cb1_on	0	100	No	Yes	No	No	4	3
353	2x64	Lig	cb1_on	0	100	No	Yes	Yes	Yes	4	0
354	2x65	Lig	cb1_on	0	100	No	Yes	Yes	Yes	4	0
355	3x22	3x26	cb1_on	0	100	No	Yes	No	No	3	5
356	3x22	E2.N256	cb1_on	0	100	No	Yes	No	Yes	3	6
357	3x22	E2.K259	cb1_on	0	100	No	Yes	No	No	3	4
358	3x29	Lig	cb1_on	0	100	No	No	Yes	Yes	4	0
359	3x33	Lig	cb1_on	0	100	No	Yes	Yes	Yes	6	0
360	3x34	4x54	cb1_on	0	100	No	No	No	No	5	4
361	3x35	3x36	cb1_on	0	100	No	No	Yes	Yes	7	7
362	3x36	3x39	cb1_on	0	100	Yes	Yes	No	No	7	9
363	3x36	7x41	cb1_on	0	100	Yes	Yes	No	No	7	7
364	3x36	Lig	cb1_on	0	100	Yes	Yes	Yes	Yes	7	0
365	3x40	6x48	cb1_on	0	100	No	No	Yes	Yes	7	8
366	3x43	7x49	cb1_on	0	100	No	No	Yes	Yes	8	9
367	3x43	7x53	cb1_on	0	100	No	No	Yes	Yes	8	9
368	3x46	3x50	cb1_on	0	100	No	No	Yes	No	9	9
369	3x46	7x53	cb1_on	0	100	No	No	Yes	Yes	9	9
370	3x47	5x54	cb1_on	0	100	No	No	No	No	8	8
371	3x50	5x58	cb1_on	0	100	Yes	No	Yes	Yes	9	9
372	3x50	7x53	cb1_on	0	100	Yes	No	Yes	Yes	9	9
373	3x54	5x61	cb1_on	0	100	No	No	No	No	9	9
374	3x55	5x60	cb1_on	0	100	No	No	No	Yes	6	4
375	4x43	4x46	cb1_on	0	100	No	No	No	No	1	8
376	5x38	E2.W255	cb1_on	0	100	No	No	Yes	Yes	5	5
377	E2.H270	E2.N256	cb1_on	0	100	Yes	Yes	No	Yes	3	6
378	5x37	E2.S265	cb1_on	0	100	No	No	No	No	3	4
379	E2.D266	E3.M371	cb1_on	0	100	No	No	No	No	4	1
380	7x31	E2.D266	cb1_on	0	100	No	No	No	No	2	4
381	E2.F268	E2.I271	cb1_on	0	100	Yes	Yes	No	Yes	5	3
382	5x39	E2.I271	cb1_on	0	100	No	Yes	No	Yes	7	3
383	E2.I271	Lig	cb1_on	0	100	No	Yes	Yes	Yes	3	0
384	5x39	5x42	cb1_on	0	100	No	Yes	No	No	7	6
385	5x39	Lig	cb1_on	0	100	No	Yes	Yes	Yes	7	0
386	5x43	6x48	cb1_on	0	100	Yes	Yes	Yes	Yes	6	8
387	5x43	Lig	cb1_on	0	100	Yes	Yes	Yes	Yes	6	0
388	5x44	6x52	cb1_on	0	100	No	No	No	Yes	5	7
389	5x44	6x55	cb1_on	0	100	No	No	No	Yes	5	6
390	5x47	6x52	cb1_on	0	100	No	No	No	Yes	8	7
391	5x51	6x44	cb1_on	0	100	No	No	No	No	6	9
392	5x58	6x40	cb1_on	0	100	Yes	Yes	No	No	9	8
393	5x58	7x53	cb1_on	0	100	Yes	Yes	Yes	Yes	9	9
394	5x60	5x63	cb1_on	0	100	No	Yes	No	No	4	3
395	5x62	6x37	cb1_on	0	100	No	No	No	Yes	6	8
396	5x69	6x30	cb1_on	0	100	No	No	No	No	0	7
397	6x28	6x32	cb1_on	0	100	No	No	No	No	4	7
398	6x40	7x53	cb1_on	0	100	No	No	Yes	Yes	8	9
399	6x43	7x48	cb1_on	0	100	No	No	No	No	6	6
400	6x43	7x52	cb1_on	0	100	No	No	No	Yes	6	9
401	6x48	6x51	cb1_on	0	100	Yes	Yes	Yes	Yes	8	7
402	6x48	6x52	cb1_on	0	100	Yes	Yes	No	Yes	8	7
403	6x55	7x34	cb1_on	0	100	No	Yes	Yes	Yes	6	4
404	6x57	E3.K370	cb1_on	0	100	No	No	No	Yes	4	1
405	7x27	E3.K370	cb1_on	0	100	No	No	No	Yes	1	1
406	7x30	E3.K370	cb1_on	0	100	Yes	No	No	Yes	3	1
407	7x28	7x32	cb1_on	0	100	No	No	No	No	3	1
408	7x34	Lig	cb1_on	0	100	Yes	Yes	Yes	Yes	4	0
409	7x52	7x53	cb1_on	0	100	No	Yes	Yes	Yes	9	9
410	7x54	8x50	cb1_on	0	100	No	No	No	Yes	7	8
411	7x55	7x56	cb1_on	0	100	No	No	No	Yes	5	7
412	NT.E106	NT.M109	cb1_on	0	100	No	No	No	No	4	3
413	2x64	NT.M109	cb1_on	0	100	No	Yes	No	No	4	3
414	1x39	2x62	cb1_on	0	100	Yes	Yes	No	No	7	5
415	1x41	1x45	cb1_on	0	100	No	No	No	No	4	4
416	I1.C149	I1x48	cb1_on	0	100	No	No	No	No	7	6
417	2x64	E1.D184	cb1_on	0	100	No	Yes	No	No	4	2
418	E1.D184	E1.R182	cb1_on	0	100	No	No	No	No	2	4
419	3x25	E1.D184	cb1_on	0	100	Yes	No	No	No	9	2
420	6x55	Lig	cb1_on	0	100	No	Yes	Yes	Yes	6	0
421	E3.K370	E3.M371	cb1_on	0	100	No	Yes	No	No	1	1
422	8x52	8x55	cb1_on	0	100	No	No	No	No	4	5
423	7x31	NT.V110	cb1_on	0	50	No	No	No	No	2	3
424	7x55	8x51	cb1_on	0	50	No	No	No	No	5	8
425	5x48	6x52	cb1_on	0	50	No	No	No	Yes	5	7
426	5x47	5x51	cb1_on	0	50	No	No	No	No	8	6
427	2x37	2x38	cb1_on	0	0	Yes	No	No	No	5	5
428	7x28	7x31	cb1_on	0	50	No	No	No	No	3	2
429	5x61	6x37	cb1_on	0	0	No	No	No	Yes	9	8
430	6x30	6x31	cb1_on	0	50	No	No	Yes	No	7	5
431	7x34	7x37	cb1_on	0	50	Yes	Yes	No	No	4	5
432	4x46	4x47	cb1_on	0	50	No	No	No	No	8	4
433	1x59	1x60	cb1_on	0	50	No	No	No	Yes	5	6
434	2x63	E1.K183	cb1_on	0	50	No	No	No	No	3	6
435	5x67	5x71	cb1_on	0	0	No	No	No	No	0	0
436	3x27	4x58	cb1_on	0	50	No	No	No	No	5	5
437	6x56	6x60	cb1_on	0	50	No	No	No	No	6	5
438	5x64	5x68	cb1_on	0	50	Yes	Yes	No	No	5	0
439	1x45	7x47	cb1_on	0	0	No	No	Yes	No	4	7
440	I2x50	I2x51	cb1_on	0	50	No	No	No	No	8	7
441	I2x52	I2x56	cb1_on	0	50	No	No	No	No	5	4
442	1x58	I1x51	cb1_on	0	50	No	No	No	No	4	8
443	1x39	2x58	cb1_on	0	50	Yes	Yes	No	No	7	7
444	5x36	E2.C257	cb1_on	0	50	Yes	No	No	No	5	9
445	8x56	8x57	cb1_on	0	50	No	No	No	No	3	5
446	3x21	3x23	cb1_on	0	50	No	No	No	No	7	1
447	5x70	6x30	cb1_on	0	50	No	No	No	No	0	7
448	1x54	1x57	cb1_on	0	0	No	No	No	No	7	7
449	2x42	4x42	cb1_on	0	50	Yes	No	No	No	8	7
450	5x62	6x33	cb1_on	0	0	No	No	No	No	6	8
451	6x33	6x37	cb1_on	0	0	No	No	No	Yes	8	8
452	3x51	5x57	cb1_on	0	0	No	No	No	No	8	7
453	1x32	1x33	cb1_on	0	50	No	No	No	No	4	5
454	5x68	5x72	cb1_on	0	50	No	No	No	No	0	0
455	2x44	2x47	cb1_on	0	0	No	No	No	No	6	9
456	1x44	1x45	cb1_on	0	50	No	No	No	No	5	4
457	1x43	1x46	cb1_on	0	0	No	No	Yes	Yes	6	7
458	3x34	4x57	cb1_on	0	0	No	No	No	No	5	7
459	6x61	E3.M371	cb1_on	0	50	No	No	No	No	3	1
460	1x55	1x56	cb1_on	0	50	No	No	Yes	No	4	8
461	E2.L260	E2.W255	cb1_on	0	50	No	No	Yes	Yes	3	5
462	4x63	E2.L260	cb1_on	0	50	No	No	No	No	5	3
463	3x33	4x57	cb1_on	0	0	No	Yes	No	No	6	7
464	6x46	6x47	cb1_on	0	0	No	No	No	No	5	8
465	6x50	7x40	cb1_on	0	50	No	No	No	No	9	7
466	1x36	2x62	cb1_on	0	50	No	No	No	No	5	5
467	5x69	6x29	cb1_on	0	50	No	No	No	No	0	6
468	6x47	7x43	cb1_on	0	0	No	No	No	No	8	5
469	7x37	7x40	cb1_on	0	0	No	No	No	No	5	7
470	5x65	6x33	cb1_on	0	0	No	No	No	No	8	8
471	1x39	1x40	cb1_on	0	0	Yes	Yes	No	No	7	3
472	2x65	7x35	cb1_on	0	0	No	Yes	No	No	4	4
473	5x70	5x74	cb1_on	0	0	No	No	No	No	0	0
474	4x48	4x52	cb1_on	0	0	No	No	No	No	3	5
475	6x44	6x45	cb1_on	0	0	No	No	No	No	9	6
476	5x63	5x66	cb1_on	0	0	No	No	No	No	3	0
477	5x45	5x49	cb1_on	0	0	No	No	No	No	3	6
478	5x76	I3.T313	cb1_on	0	0	No	No	No	No	0	0
479	4x47	4x51	cb1_on	0	0	No	No	No	No	4	4
480	5x73	6x27	cb1_on	0	0	No	No	No	No	0	4
481	6x42	6x43	cb1_on	0	0	No	No	No	No	6	6
482	1x52	1x55	cb1_on	0	0	No	No	No	No	7	4
483	4x51	4x55	cb1_on	0	0	No	No	No	No	4	3
484	7x32	7x33	cb1_on	0	0	No	No	No	No	1	4
485	4x41	4x44	cb1_on	0	0	No	No	No	No	5	3
486	5x75	5x76	cb1_on	0	0	No	No	No	No	0	0
487	6x37	6x38	cb1_on	0	0	No	Yes	No	No	8	6
488	1x47	1x48	cb1_on	0	0	No	No	No	No	6	3
489	5x52	5x55	cb1_on	0	0	No	No	No	No	4	5
490	5x59	6x41	cb1_on	0	0	No	No	No	No	3	8
491	1x34	7x36	cb1_on	0	0	No	No	No	No	5	4
492	E2.E258	E2.Q261	cb1_on	0	0	Yes	No	No	No	1	1

Orange: nodes, hubs and links specific of cb1_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of cb1_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	cb1_off Avg Int. Strength	cb1_on Avg Int. Strength	cb1_off Num Of Links	cb1_on Num Of Links	ConSurf
1	NT.N101	cb1_off	50	0	4	0	6
2	NT.F102	cb1_off	100	0	5	0	5
3	NT.M103	cb1_off	100	0	5	0	4
4	NT.F108	cb1_off	50	50	5	2	5
5	NT.L111	cb1_off	50	0	4	2	4
6	1x28	cb1_off	0	0	5	3	6
7	1x49	cb1_off	0	0	5	2	8
8	1x56	cb1_off	0	0	4	3	8
9	2x37	cb1_off	0	0	4	3	5
10	2x42	cb1_off	50	0	4	3	8
11	3x25	cb1_off	100	50	4	3	9
12	3x28	cb1_off	50	0	5	2	6
13	3x49	cb1_off	50	100	4	3	9
14	3x50	cb1_off	100	0	6	3	9
15	3x56	cb1_off	0	0	4	2	5
16	I2x57	cb1_off	50	50	4	2	6
17	E2.E258	cb1_off	100	0	4	3	1
18	E2.I267	cb1_off	100	50	4	3	4
19	5x36	cb1_off	0	50	4	3	5
20	6x31	cb1_off	0	0	4	1	5
21	6x58	cb1_off	50	0	4	2	4
22	6x59	cb1_off	0	0	4	2	4
23	7x30	cb1_off	0	0	4	1	3
24	7x45	cb1_off	100	0	5	3	9
25	7x47	cb1_off	0	0	5	3	7
26	Lig	Shared	100	100	12	15	0
27	1x39	Shared	0	50	4	4	7
28	1x46	Shared	0	50	4	4	7
29	2x40	Shared	100	100	5	6	9
30	2x46	Shared	0	50	4	4	9
31	2x57	Shared	100	100	6	4	7
32	2x61	Shared	50	100	5	6	5
33	3x36	Shared	100	100	6	4	7
34	I2x53	Shared	100	50	6	4	7
35	4x50	Shared	100	0	6	4	9
36	E2.W255	Shared	100	50	4	4	5
37	E2.F268	Shared	100	50	4	4	5
38	E2.H270	Shared	100	0	5	4	3
39	5x43	Shared	100	100	6	6	6
40	5x58	Shared	50	100	6	6	9
41	5x64	Shared	0	0	4	4	5
42	6x48	Shared	100	50	4	5	8
43	6x51	Shared	50	0	4	4	7
44	7x34	Shared	100	100	4	6	4
45	7x49	Shared	50	50	4	4	9
46	7x53	Shared	50	100	4	6	9
47	1x60	cb1_on	0	0	2	4	6
48	2x50	cb1_on	0	100	3	5	9
49	2x64	cb1_on	0	100	3	6	4
50	2x65	cb1_on	0	50	2	5	4
51	3x22	cb1_on	0	100	3	6	3
52	3x33	cb1_on	0	0	2	4	6
53	E2.N256	cb1_on	0	0	3	5	6
54	E2.I271	cb1_on	0	50	3	6	3
55	5x39	cb1_on	50	100	3	6	7
56	5x60	cb1_on	50	100	3	5	4
57	6x37	cb1_on	0	0	3	5	8
58	6x52	cb1_on	0	0	2	4	7
59	6x55	cb1_on	50	50	3	4	6
60	E3.K370	cb1_on	0	0	1	4	1
61	7x52	cb1_on	0	100	2	4	9
62	7x56	cb1_on	0	0	3	4	7
63	8x50	cb1_on	0	100	2	5	8

Orange: nodes, hubs and links specific of cb1_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of cb1_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	cb1_off Recurrence	cb1_on Recurrence	cb1_off Hub1?	cb1_on Hub1?	cb1_off Hub2?	cb1_on Hub2?	ConSurf1	ConSurf2
1	Lig	NT.F102	cb1_off	26.2594	0	Yes	Yes	Yes	No	0	5
2	3x25	NT.F102	cb1_off	16.1474	0	Yes	No	Yes	No	9	5
3	3x28	NT.F102	cb1_off	12.8612	0	Yes	No	Yes	No	6	5
4	Lig	NT.I105	cb1_off	15.7355	0	Yes	Yes	No	No	0	3
5	NT.E106	NT.I105	cb1_off	14.9788	0	No	No	No	No	4	3
6	6x51	7x34	cb1_off	14.4845	9.31895	Yes	Yes	Yes	Yes	7	4
7	NT.E106	NT.L111	cb1_off	14.039	0	No	No	Yes	No	4	4
8	1x31	NT.L111	cb1_off	11.5369	0	No	No	Yes	No	2	4
9	1x28	1x31	cb1_off	10.5819	4.03976	Yes	No	No	No	6	2
10	1x46	1x49	cb1_off	10.3225	0	Yes	Yes	Yes	No	7	8
11	1x46	7x42	cb1_off	13.8498	0	Yes	Yes	No	No	7	7
12	6x48	7x41	cb1_off	74.6041	0	Yes	Yes	No	No	8	7
13	7x41	Lig	cb1_off	58.9601	0	No	No	Yes	Yes	7	0
14	1x53	7x50	cb1_off	13.3158	0	No	No	No	No	9	9
15	1x53	7x53	cb1_off	14.2617	0	No	No	Yes	Yes	9	9
16	7x49	7x53	cb1_off	97.8366	0	Yes	Yes	Yes	Yes	9	9
17	2x46	7x53	cb1_off	44.0485	0	Yes	Yes	Yes	Yes	9	9
18	1x57	2x44	cb1_off	67.0369	0	No	No	No	No	7	6
19	2x43	2x44	cb1_off	67.8241	0	No	No	No	No	8	6
20	2x43	7x53	cb1_off	74.7719	0	No	No	Yes	Yes	8	9
21	1x57	I1x50	cb1_off	66.4205	0	No	No	No	No	7	9
22	1x56	8x50	cb1_off	10.289	6.42555	Yes	No	No	Yes	8	8
23	8x47	8x50	cb1_off	11.421	0.0549915	No	No	No	Yes	8	8
24	2x40	8x47	cb1_off	12.4859	1.45939	Yes	Yes	No	No	9	8
25	2x41	4x46	cb1_off	12.9283	0	No	No	No	No	3	8
26	2x39	2x40	cb1_off	48.7535	0	No	No	Yes	Yes	8	9
27	3x49	I2x57	cb1_off	19.9066	0	Yes	No	Yes	No	9	6
28	2x39	3x49	cb1_off	48.6773	1.55668	No	No	Yes	No	8	9
29	2x42	2x43	cb1_off	29.3839	0	Yes	No	No	No	8	8
30	2x42	2x46	cb1_off	26.2106	0	Yes	No	Yes	Yes	8	9
31	2x42	6x37	cb1_off	40.1733	0	Yes	No	No	Yes	8	8
32	3x29	E2.F268	cb1_off	10.4019	0.0634518	No	No	Yes	Yes	4	5
33	3x36	5x43	cb1_off	37.7109	0	Yes	Yes	Yes	Yes	7	6
34	3x36	6x48	cb1_off	36.646	0	Yes	Yes	Yes	Yes	7	8
35	3x36	3x40	cb1_off	12.4584	0	Yes	Yes	No	No	7	7
36	3x51	3x55	cb1_off	19.095	0.0296108	No	No	No	No	8	6
37	3x55	3x56	cb1_off	21.2584	7.35618	No	No	Yes	No	6	5
38	3x56	I2x56	cb1_off	29.8508	0	Yes	No	No	No	5	4
39	3x52	I2x56	cb1_off	31.9836	4.67851	No	No	No	No	5	4
40	3x52	I2x53	cb1_off	17.2917	0	No	No	Yes	Yes	5	7
41	3x52	I2x57	cb1_off	16.8157	6.2225	No	No	Yes	No	5	6
42	3x51	5x60	cb1_off	16.9255	4.87733	No	No	No	Yes	8	4
43	5x66	6x31	cb1_off	15.5616	0	No	No	Yes	No	0	5
44	5x62	5x66	cb1_off	18.5458	0	No	No	No	No	6	0
45	5x62	6x38	cb1_off	22.0547	0	No	No	No	No	6	6
46	5x58	6x38	cb1_off	27.2755	0	Yes	Yes	No	No	9	6
47	6x51	7x41	cb1_off	15.4212	0.905245	Yes	Yes	No	No	7	7
48	6x44	7x45	cb1_off	21.0966	0	No	No	Yes	No	9	9
49	3x36	6x44	cb1_off	20.6511	0	Yes	Yes	No	No	7	9
50	2x57	7x42	Shared	13.923	12.077	Yes	Yes	No	No	7	7
51	2x57	Lig	Shared	11.7261	13.7606	Yes	Yes	Yes	Yes	7	0
52	1x49	7x50	Shared	14.5547	18.1599	Yes	No	No	No	8	9
53	7x45	7x49	Shared	100	51.9543	Yes	No	Yes	Yes	9	9
54	6x48	7x45	Shared	79.0193	52.6142	Yes	Yes	Yes	No	8	9
55	2x45	4x50	Shared	14.0604	28.1853	No	No	Yes	Yes	9	9
56	2x45	3x42	Shared	30.9981	49.7081	No	No	No	No	9	8
57	2x46	3x42	Shared	32.1667	50.9814	Yes	Yes	No	No	9	8
58	2x40	I1x50	Shared	64.0863	10.7318	Yes	Yes	No	No	9	9
59	2x45	4x46	Shared	16.358	22.6481	No	No	No	No	9	8
60	E2.F268	Lig	Shared	15.5707	15.2284	Yes	Yes	Yes	Yes	5	0
61	5x58	6x37	Shared	38.8094	66.3875	Yes	Yes	No	Yes	9	8
62	3x49	I2x53	Shared	20.9227	12.1235	Yes	No	Yes	Yes	9	7
63	5x39	E2.W255	Shared	18.6068	14.7293	No	Yes	Yes	Yes	7	5
64	5x39	5x43	Shared	21.6642	10.3257	No	Yes	Yes	Yes	7	6
65	5x60	5x64	Shared	12.5683	37.7623	No	Yes	Yes	Yes	4	5
66	1x32	NT.L111	cb1_on	0	18.5237	No	No	Yes	No	4	4
67	2x65	NT.L111	cb1_on	0	20.3299	No	Yes	Yes	No	4	4
68	1x35	7x36	cb1_on	0	12.0516	No	No	No	No	5	4
69	1x35	2x61	cb1_on	0	14.0017	No	No	Yes	Yes	5	5
70	2x61	Lig	cb1_on	0	15.8503	Yes	Yes	Yes	Yes	5	0
71	2x64	Lig	cb1_on	0	83.6675	No	Yes	Yes	Yes	4	0
72	1x32	2x66	cb1_on	0	14.8858	No	No	No	No	4	4
73	1x42	7x42	cb1_on	0	11.066	No	No	No	No	6	7
74	1x42	7x47	cb1_on	1.1839	10.9941	No	No	Yes	No	6	7
75	1x46	7x46	cb1_on	0	16.1125	Yes	Yes	No	No	7	9
76	2x50	7x46	cb1_on	1.18085	17.6015	No	Yes	No	No	9	9
77	2x50	3x39	cb1_on	0	97.9992	No	Yes	No	No	9	9
78	3x36	3x39	cb1_on	0	97.9992	Yes	Yes	No	No	7	9
79	3x36	Lig	cb1_on	0	97.4789	Yes	Yes	Yes	Yes	7	0
80	1x46	7x47	cb1_on	3.13978	10.9306	Yes	Yes	Yes	No	7	7
81	1x46	2x54	cb1_on	5.88594	11.4382	Yes	Yes	No	No	7	7
82	1x50	7x50	cb1_on	2.69429	19.6785	No	No	No	No	9	9
83	1x50	2x50	cb1_on	2.77362	54.0313	No	No	No	Yes	9	9
84	1x49	7x51	cb1_on	3.32286	16.6328	Yes	No	No	No	8	6
85	1x50	2x47	cb1_on	0	35.6134	No	No	No	No	9	9
86	2x40	8x50	cb1_on	0	10.7149	Yes	Yes	No	Yes	9	8
87	1x57	2x40	cb1_on	0	28.3883	No	No	Yes	Yes	7	9
88	1x54	1x57	cb1_on	0	29.8604	No	No	No	No	7	7
89	1x54	2x47	cb1_on	0	32.7538	No	No	No	No	7	9
90	2x46	2x50	cb1_on	0	63.7394	Yes	Yes	No	Yes	9	9
91	4x43	4x46	cb1_on	0	16.7936	No	No	No	No	1	8
92	2x41	4x43	cb1_on	2.63327	15.3088	No	No	No	No	3	1
93	2x41	4x39	cb1_on	9.11726	13.8156	No	No	No	No	3	1
94	2x42	3x49	cb1_on	0	15.1184	Yes	No	Yes	No	8	9
95	2x42	3x45	cb1_on	0	18.088	Yes	No	No	No	8	6
96	3x45	4x49	cb1_on	0.131206	21.0152	No	No	No	No	6	6
97	4x49	4x50	cb1_on	2.60885	23.9086	No	No	Yes	Yes	6	9
98	3x43	7x53	cb1_on	0	100	No	No	Yes	Yes	8	9
99	2x46	3x43	cb1_on	0	37.3858	Yes	Yes	No	No	9	8
100	3x43	7x49	cb1_on	0	64.7039	No	No	Yes	Yes	8	9
101	2x50	7x49	cb1_on	4.8302	36.5948	No	Yes	Yes	Yes	9	9
102	5x43	6x48	cb1_on	0	40.8164	Yes	Yes	Yes	Yes	6	8
103	5x43	Lig	cb1_on	0	32.8426	Yes	Yes	Yes	Yes	6	0
104	2x64	E1.D184	cb1_on	0	44.3824	No	Yes	No	No	4	2
105	3x25	E1.D184	cb1_on	0	38.3883	Yes	No	No	No	9	2
106	3x25	E2.H270	cb1_on	7.16443	36.7766	Yes	No	Yes	Yes	9	3
107	3x22	E2.H270	cb1_on	2.11455	40.0381	No	Yes	Yes	Yes	3	3
108	2x64	NT.F108	cb1_on	0	39.0482	No	Yes	Yes	No	4	5
109	E2.P269	NT.F108	cb1_on	0	37.5804	No	No	Yes	No	3	5
110	E2.H270	E2.P269	cb1_on	0.0244103	36.2606	Yes	Yes	No	No	3	3
111	3x22	3x23	cb1_on	1.08626	10.1988	No	Yes	No	No	3	1
112	3x22	3x26	cb1_on	0	16.9374	No	Yes	No	No	3	5
113	E2.H270	E2.N256	cb1_on	0	29.9746	Yes	Yes	No	Yes	3	6
114	3x26	E2.N256	cb1_on	3.04824	16.6244	No	No	No	Yes	5	6
115	3x26	4x61	cb1_on	2.16947	27.0685	No	No	No	No	5	5
116	3x27	4x61	cb1_on	1.08626	20.313	No	No	No	No	5	5
117	5x58	7x53	cb1_on	0	79.7504	Yes	Yes	Yes	Yes	9	9
118	5x61	6x37	cb1_on	0	53.5491	No	No	No	Yes	9	8
119	3x54	5x61	cb1_on	0	51.2817	No	No	No	No	9	9
120	3x54	5x64	cb1_on	2.20914	49.3063	No	No	Yes	Yes	9	5
121	5x39	Lig	cb1_on	0	15.8376	No	Yes	Yes	Yes	7	0
122	E2.I271	Lig	cb1_on	0	12.3181	No	Yes	Yes	Yes	3	0
123	E2.F268	E2.I267	cb1_on	5.05904	15.5076	Yes	Yes	Yes	No	5	4
124	6x58	E2.I267	cb1_on	9.28813	34.1074	Yes	No	Yes	No	4	4
125	6x58	E2.D266	cb1_on	2.29457	31.7259	Yes	No	No	No	4	4
126	7x34	Lig	cb1_on	0	19.797	Yes	Yes	Yes	Yes	4	0
127	7x34	E2.I267	cb1_on	3.92091	20.8545	Yes	Yes	Yes	No	4	4
128	E2.D266	E3.M371	cb1_on	0	14.8181	No	No	No	No	4	1
129	7x31	E2.D266	cb1_on	0	14.8181	No	No	No	No	2	4
130	5x60	5x63	cb1_on	0	18.8409	No	Yes	No	No	4	3
131	5x63	5x66	cb1_on	0	16.4382	No	No	No	No	3	0
132	5x66	5x70	cb1_on	1.52259	14.0271	No	No	No	No	0	0
133	7x51	7x55	cb1_on	1.66295	15.0973	No	No	No	No	6	5
134	7x52	7x53	cb1_on	0	11.6751	No	Yes	Yes	Yes	9	9
135	2x62	2x66	cb1_on	1.16864	11.214	No	No	No	No	5	4
136	3x27	4x58	cb1_on	0	13.5491	No	No	No	No	5	5
137	2x65	Lig	cb1_on	0	19.0398	No	Yes	Yes	Yes	4	0
138	6x48	6x51	cb1_on	0	10.4442	Yes	Yes	Yes	Yes	8	7
139	2x46	7x49	cb1_on	0	11.2479	Yes	Yes	Yes	Yes	9	9

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
Lig	NT.F102	cb1_off	4.59	0	1	1	0	1
Lig	NT.M103	cb1_off	11.97	0	1	1	0	1
Lig	NT.I105	cb1_off	11.08	0	1	1	0	1
1x39	Lig	cb1_off	4.22	0	1	0	1	0
2x57	Lig	Shared	12.675	10.115	1	1	1	0
3x32	Lig	Shared	16.325	5.455	0	0	1	0
E2.F268	Lig	Shared	7.3	13.2	1	1	1	0
6x51	Lig	cb1_off	4.815	0	1	1	1	0
7x38	Lig	cb1_off	17.415	0	0	1	1	0
7x39	Lig	cb1_off	8.81	0	0	1	1	0
7x41	Lig	cb1_off	4.965	0	1	0	1	0
2x64	NT.N101	cb1_off	13.29	0	0	1	1	2
E1.D184	NT.N101	cb1_off	7.405	0	0	0	2	2
NT.F102	NT.M103	cb1_off	4.975	0	1	0	1	1
2x60	NT.F102	cb1_off	5.28	0	1	0	1	1
3x25	NT.F102	cb1_off	6.965	0	1	3	2	1
3x28	NT.F102	cb1_off	9.31	0	1	0	2	1
2x57	NT.M103	cb1_off	6.84	0	1	1	1	1
2x60	NT.M103	cb1_off	6.135	0	1	0	1	1
2x61	NT.M103	cb1_off	3.735	0	0	1	1	1
2x64	NT.D104	cb1_off	9.555	0	0	1	1	2
NT.E106	NT.I105	cb1_off	4.1	0	0	0	2	1
NT.E106	NT.L111	cb1_off	5.3	0	0	0	2	2
7x34	NT.F108	cb1_off	5.36	0	0	1	1	2
1x39	2x57	cb1_off	3.965	0	1	0	1	1
1x39	2x61	cb1_off	4.625	0	1	0	1	1
1x40	2x61	cb1_off	6.09	0	0	0	2	1
2x57	7x42	Shared	11.57	4.265	1	1	1	2
2x60	3x28	Shared	7.65	4.59	1	0	1	2
2x61	2x65	Shared	16.4	7.92	0	1	1	1
2x64	2x65	Shared	10.75	7.35	0	1	1	1
3x28	E1.D184	cb1_off	9.68	0	1	0	2	2
3x29	E2.F268	Shared	7.92	4.265	0	1	1	1
3x29	E2.I271	Shared	3.565	3.57	0	1	1	1
3x33	5x43	Shared	10.915	6.065	0	1	1	1
3x36	3x40	cb1_off	6.555	0	1	0	1	2
3x36	5x43	cb1_off	5.515	0	1	0	1	1
3x36	5x47	cb1_off	6.505	0	1	0	1	2
3x36	6x44	cb1_off	4.87	0	1	0	1	2
3x36	6x48	cb1_off	29.565	0	1	0	1	2
3x36	6x52	cb1_off	4.26	0	1	0	1	2
3x37	5x43	Shared	6.065	8.49	0	0	2	1
4x60	5x39	Shared	19.47	9.04	0	0	2	1
5x39	E2.W255	Shared	13.985	13.02	0	1	1	2
5x42	E2.W255	cb1_off	4.01	0	0	0	2	2
E2.I271	E2.S265	Shared	4.645	1.55	0	1	1	2
E2.F268	E2.I267	Shared	10.05	9.42	1	1	1	2
6x55	E2.I267	cb1_off	3.645	0	1	1	1	2
7x34	E2.I267	Shared	9.42	8.16	0	1	1	2
6x55	E2.F268	cb1_off	4.975	0	1	1	1	1
5x40	E2.I271	Shared	4.995	3.57	0	0	2	1
5x43	5x44	cb1_off	5.285	0	1	1	1	2
5x43	5x47	Shared	6.11	9.195	1	1	1	2
6x44	6x48	cb1_off	3.415	0	1	0	2	2
6x48	7x41	cb1_off	18.28	0	1	0	2	1
6x51	6x55	Shared	4.24	3.535	1	1	1	1
6x51	7x34	Shared	6.09	3.655	1	1	1	1
6x51	7x41	Shared	4.76	3.965	1	1	1	1
6x54	7x34	Shared	6.91	7.535	0	0	2	1
1x43	2x57	cb1_off	3.01	0	0	0	2	1
1x36	2x61	cb1_off	2.77	0	0	0	2	1
3x30	3x33	Shared	2.73	2.73	0	0	2	1
5x39	5x43	Shared	2.41	3.855	0	1	1	1
2x56	3x32	Shared	2.305	3.07	0	0	2	1
1x35	NT.L111	cb1_off	2.14	0	0	1	2	2
2x53	Lig	cb1_off	2.125	0	0	0	1	0
7x35	NT.F108	cb1_off	2.08	0	0	0	2	2
2x57	2x58	cb1_off	1.965	0	1	1	1	2
3x30	4x57	cb1_off	1.95	0	0	0	2	2
2x53	3x35	Shared	1.855	3.71	0	0	1	2
1x38	1x39	Shared	1.5	1.5	0	0	2	1
2x64	NT.F108	cb1_on	0	4.825	0	1	1	2
E1.H181	NT.M109	cb1_on	0	3.28	0	1	2	2
2x65	NT.L111	cb1_on	0	3.215	0	1	1	2
1x35	2x61	cb1_on	0	3.77	0	1	2	1
1x35	7x39	cb1_on	0	3.645	0	1	2	1
2x57	2x61	cb1_on	0	10.715	1	1	1	1
2x57	7x38	cb1_on	0	4.62	1	1	1	1
2x60	Lig	cb1_on	0	4.72	1	0	1	0
2x61	7x38	cb1_on	0	5.945	0	1	1	1
2x61	7x39	cb1_on	0	3.11	0	1	1	1
2x61	Lig	cb1_on	0	3.09	0	1	1	0
2x64	E1.H181	cb1_on	0	5.09	0	1	1	2
2x64	Lig	cb1_on	0	14.115	0	1	1	0
2x65	Lig	cb1_on	0	6.455	0	1	1	0
3x29	Lig	cb1_on	0	6.365	0	1	1	0
3x33	Lig	cb1_on	0	9.2	0	1	1	0
3x35	3x36	cb1_on	0	4.62	0	0	2	1
3x36	3x39	cb1_on	0	3.305	1	0	1	2
3x36	7x41	cb1_on	0	9.08	1	0	1	1
3x36	Lig	cb1_on	0	5.375	1	0	1	0
3x40	6x48	cb1_on	0	6.13	0	0	2	2
E2.F268	E2.I271	cb1_on	0	7.535	1	1	1	1
5x39	E2.I271	cb1_on	0	6.65	0	1	1	1
E2.I271	Lig	cb1_on	0	3.415	0	1	1	0
5x39	5x42	cb1_on	0	3.61	0	1	1	2
5x39	Lig	cb1_on	0	5.06	0	1	1	0
5x43	6x48	cb1_on	0	3.28	1	1	1	2
5x43	Lig	cb1_on	0	15.34	1	1	1	0
5x44	6x52	cb1_on	0	4.28	0	0	2	2
5x44	6x55	cb1_on	0	7.29	0	0	2	1
5x47	6x52	cb1_on	0	3.725	1	0	2	2
6x48	6x51	cb1_on	0	4.555	1	0	2	1
6x48	6x52	cb1_on	0	3.985	1	0	2	2
6x55	7x34	cb1_on	0	3.735	1	1	1	1
7x34	Lig	cb1_on	0	3.2	0	1	1	0
NT.E106	NT.M109	cb1_on	0	4.06	0	0	2	2
2x64	NT.M109	cb1_on	0	3.11	0	1	1	2
1x39	2x62	cb1_on	0	3.095	1	0	1	2
2x64	E1.D184	cb1_on	0	3.585	0	1	1	2
3x25	E1.D184	cb1_on	0	5.375	1	3	2	2
6x55	Lig	cb1_on	0	3.185	1	1	1	0
7x34	7x37	cb1_on	0	2.795	0	1	1	2
1x39	2x58	cb1_on	0	2.425	1	0	1	2
3x33	4x57	cb1_on	0	1.68	0	1	1	2
1x36	2x62	cb1_on	0	1.625	0	0	2	2
1x39	1x40	cb1_on	0	1.5	1	0	1	2
2x65	7x35	cb1_on	0	1.465	0	1	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	cb1_off	5U09-CB₁-Taranabant 5TGZ-CB₁-AM6538
	cb1_on	6KPG-CB₁-AM841-Gi1/β1/γ2 8K8J-CB₁-Fenofibrate-chim(Gs-CtGq)/β1/γ2

Network Difference
Value	cb1_off	cb1_on
I_min	3.4	3.075
Number of Linked Nodes	284	282
Number of Specific Nodes	14 (4.93%)	12 (4.26%)
Number of Shared Nodes	270 (95.07%)	270 (95.74%)
Number of Links	315	318
Number of Specific Links	174 (55.24%)	177 (55.66%)
Number of Shared Links	141 (44.76%)	141 (44.34%)
Number of Hubs	46	38
Number of Specific Hubs	25 (54.35%)	17 (44.74%)
Number of Shared Hubs	21 (45.65%)	21 (55.26%)
Average % Shared Neighbours (Jaccard)	32.92
Average % Shared Neighbours (Otsuka)	41.41
Average % Shared Neighbours (Overlap Coefficient)	49.47
Average % Shared Cliques (k3-6)	50.94
Graphlets Similarity	0.671093

Paths Difference
Value	cb1_off	cb1_on
Number Of Nodes in MetaPath	62	83
Specific Nodes in MetaPath	25 (40.32%)	46 (55.42%)
Shared Nodes in MetaPath	270 (95.07%)	270 (95.07%)
Number Of Links MetaPath	65	90
Specific Links in MetaPath	49 (75.38%)	74 (82.22%)
Shared Links in MetaPath	141 (44.76%)	141 (44.76%)
Number of Shortest Paths	63052	66937
Length Of Smallest Path	3	3
Average Path Length	14.1993	13.1435
Length of Longest Path	32	29
Minimum Path Strength	0.7525	0.765
Average Path Strength	6.61941	5.43428
Maximum Path Strength	23.9225	13.8075
Minimum Path Correlation	0.7	0.7
Average Path Correlation	0.918106	0.926359
Maximum Path Correlation	0.99	0.99
Minimum % Of Corr. Nodes	3.33333	4.16667
Average % Of Corr. Nodes	40.876	47.7822
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	47.9436	43.6338
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

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