psnGPCR

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Orange: nodes, hubs and links specific of cb2_on network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of cb2_off network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	cb2_on Int. Strength	cb2_off Int. Strength	cb2_on Hub1?	cb2_off Hub1?	cb2_on Hub2?	cb2_off Hub2?	ConSurf1	ConSurf2
1	NT.M22	NT.Y25	cb2_on	3.19167	0	Yes	No	No	No	7	4
2	2x64	NT.M22	cb2_on	3.11167	0	Yes	Yes	Yes	No	3	7
3	1x31	NT.L28	cb2_on	3.32667	0	No	No	No	No	5	6
4	2x65	NT.L28	cb2_on	3.85667	0	Yes	No	No	No	4	6
5	7x32	NT.L28	cb2_on	3.525	0	No	No	No	No	2	6
6	1x28	1x32	cb2_on	3.06	0	No	No	Yes	No	7	5
7	1x31	7x36	cb2_on	8.785	0	No	No	No	No	5	4
8	1x32	E1.H98	cb2_on	3.71167	0	Yes	No	No	No	5	4
9	1x42	7x42	cb2_on	3.23	0	Yes	No	No	No	6	6
10	1x42	7x43	cb2_on	3.33	0	Yes	No	No	No	6	4
11	1x42	7x47	cb2_on	4.71	0	Yes	No	Yes	No	6	6
12	1x50	2x51	cb2_on	4.63167	0	No	No	Yes	Yes	9	7
13	1x54	2x48	cb2_on	3.135	0	No	No	No	No	7	7
14	I1.R66	I1x49	cb2_on	4.09	0	No	No	No	No	7	6
15	8x49	I1x50	cb2_on	4.42	0	Yes	Yes	No	No	6	8
16	2x38	I2x57	cb2_on	4.10333	0	No	No	No	No	5	6
17	2x39	3x49	cb2_on	6.13667	0	No	No	Yes	Yes	8	9
18	2x42	3x45	cb2_on	9.54	0	Yes	No	No	No	8	6
19	2x46	3x42	cb2_on	5.50667	0	Yes	No	No	No	9	8
20	2x46	7x53	cb2_on	4.10333	0	Yes	No	Yes	Yes	9	9
21	2x50	7x49	cb2_on	3.81333	0	No	Yes	No	No	9	9
22	2x53	3x36	cb2_on	3.92833	0	No	No	Yes	No	8	6
23	2x57	3x32	cb2_on	4.58667	0	Yes	No	No	No	6	5
24	2x57	3x36	cb2_on	4.82333	0	Yes	No	Yes	No	6	6
25	2x57	7x38	cb2_on	4.62333	0	Yes	No	No	No	6	5
26	2x57	7x42	cb2_on	5.88667	0	Yes	No	No	No	6	6
27	2x60	3x28	cb2_on	5.865	0	No	No	No	No	4	5
28	2x61	7x39	cb2_on	3.52333	0	Yes	Yes	No	No	6	5
29	3x34	4x50	cb2_on	3.10333	0	Yes	No	Yes	No	5	9
30	3x36	7x41	cb2_on	5.35333	0	Yes	No	No	No	6	7
31	3x40	6x48	cb2_on	3.065	0	No	No	Yes	Yes	8	8
32	3x43	7x53	cb2_on	7.425	0	No	No	Yes	Yes	8	9
33	3x45	4x45	cb2_on	3.68333	0	No	No	No	No	6	6
34	3x46	3x50	cb2_on	3.44833	0	No	No	No	Yes	9	9
35	3x46	7x53	cb2_on	4.37	0	No	No	Yes	Yes	9	9
36	3x47	5x57	cb2_on	3.35833	0	No	No	No	No	9	6
37	3x47	5x58	cb2_on	7.11667	0	No	No	Yes	Yes	9	9
38	3x50	5x58	cb2_on	6.17167	0	No	Yes	Yes	Yes	9	9
39	3x50	7x53	cb2_on	8.40333	0	No	Yes	Yes	Yes	9	9
40	3x51	5x60	cb2_on	7.62167	0	No	No	No	No	8	5
41	3x54	5x61	cb2_on	3.47667	0	No	No	No	No	9	9
42	3x56	I2x56	cb2_on	3.125	0	Yes	No	No	No	5	4
43	I2x53	I2x54	cb2_on	4.18	0	Yes	Yes	No	No	7	5
44	4x46	4x50	cb2_on	4.555	0	Yes	No	Yes	No	8	9
45	5x36	E2.W172	cb2_on	8.33167	0	Yes	Yes	Yes	Yes	4	5
46	5x40	E2.S180	cb2_on	3	0	No	No	No	No	5	4
47	E2.F183	E2.I186	cb2_on	3.76833	0	Yes	No	Yes	Yes	6	5
48	6x55	E2.F183	cb2_on	4.56167	0	Yes	No	Yes	No	6	6
49	7x34	E2.F183	cb2_on	5.895	0	Yes	No	Yes	No	4	6
50	E2.P184	Lig	cb2_on	5.51167	0	No	No	Yes	Yes	5	0
51	5x39	E2.I186	cb2_on	3.42667	0	Yes	Yes	Yes	Yes	7	5
52	5x36	5x39	cb2_on	3.01167	0	Yes	Yes	Yes	Yes	4	7
53	5x39	5x43	cb2_on	4.98167	0	Yes	Yes	Yes	Yes	7	5
54	5x40	6x55	cb2_on	3.53333	0	No	No	Yes	No	5	6
55	5x43	6x55	cb2_on	3.87667	0	Yes	Yes	Yes	No	5	6
56	5x51	6x44	cb2_on	4.26167	0	Yes	No	No	No	7	9
57	5x51	6x48	cb2_on	8.01667	0	Yes	No	Yes	Yes	7	8
58	5x58	6x40	cb2_on	3.57667	0	Yes	Yes	No	No	9	8
59	5x58	7x53	cb2_on	3.47333	0	Yes	Yes	Yes	Yes	9	9
60	5x61	6x37	cb2_on	2.98	0	No	No	No	No	9	8
61	5x62	6x37	cb2_on	3.69	0	No	No	No	No	6	8
62	5x66	6x30	cb2_on	7.56	0	No	No	Yes	No	5	7
63	5x69	6x29	cb2_on	3.725	0	No	No	No	Yes	5	5
64	5x69	6x30	cb2_on	8.52	0	No	No	Yes	No	5	7
65	6x31	6x35	cb2_on	3.28833	0	No	No	No	No	5	7
66	6x43	7x52	cb2_on	3.84167	0	No	No	Yes	No	7	9
67	6x48	7x45	cb2_on	6.40333	0	Yes	Yes	No	No	8	9
68	7x29	7x32	cb2_on	10.8483	0	No	No	No	No	3	2
69	7x34	Lig	cb2_on	6.41333	0	Yes	No	Yes	Yes	4	0
70	7x45	7x49	cb2_on	8.40167	0	No	No	No	No	9	9
71	8x48	8x51	cb2_on	5.00333	0	No	No	No	No	4	8
72	3x37	5x47	cb2_on	3.29333	0	No	No	No	No	6	7
73	8x60	8x61	cb2_on	4.585	0	No	No	No	No	0	0
74	2x41	4x42	cb2_on	2.89167	0	No	No	No	No	4	7
75	6x39	7x52	cb2_on	2.855	0	No	No	Yes	No	6	9
76	6x51	7x34	cb2_on	2.83833	0	No	No	Yes	No	6	4
77	1x53	7x54	cb2_on	2.82833	0	No	No	No	No	9	8
78	7x52	7x53	cb2_on	2.82167	0	Yes	No	Yes	Yes	9	9
79	1x53	1x57	cb2_on	2.815	0	No	No	No	No	9	8
80	2x49	4x50	cb2_on	2.80667	0	No	No	Yes	No	8	9
81	2x37	2x38	cb2_on	2.79	0	No	No	No	No	6	5
82	3x44	5x50	cb2_on	2.76667	0	Yes	No	Yes	No	6	7
83	4x58	4x61	cb2_on	2.73333	0	Yes	No	Yes	No	4	6
84	7x28	7x30	cb2_on	2.67833	0	No	No	No	No	3	3
85	6x47	7x40	cb2_on	2.645	0	No	No	No	No	8	8
86	3x25	E2.L185	cb2_on	2.63833	0	Yes	Yes	No	No	9	4
87	5x51	6x52	cb2_on	2.63833	0	Yes	No	No	No	7	6
88	1x60	I1x49	cb2_on	2.405	0	No	No	No	No	7	6
89	1x56	8x57	cb2_on	2.37833	0	No	No	No	No	8	0
90	1x29	1x32	cb2_on	2.32333	0	No	No	Yes	No	4	5
91	I3.H226	I3.Q227	cb2_on	2.26833	0	No	No	No	No	4	2
92	7x54	8x50	cb2_on	2.16333	0	No	No	No	Yes	8	8
93	5x68	6x29	cb2_on	2.14167	0	No	Yes	No	Yes	7	5
94	I3.Q227	I3.Q230	cb2_on	2.13333	0	No	No	No	No	2	0
95	5x62	6x34	cb2_on	2.10333	0	No	No	No	No	6	8
96	6x29	6x33	cb2_on	2.07667	0	No	Yes	No	No	5	7
97	3x54	6x33	cb2_on	2.075	0	No	No	No	No	9	7
98	4x39	4x43	cb2_on	2.02333	0	No	No	No	No	3	1
99	2x63	E1.F97	cb2_on	2.01333	0	No	No	No	No	3	3
100	E1.H98	NT.K23	cb2_on	1.965	0	No	No	No	No	4	4
101	8x60	8x63	cb2_on	1.965	0	No	No	No	No	0	0
102	6x28	6x31	cb2_on	1.96333	0	No	Yes	No	No	4	5
103	3x52	3x56	cb2_on	1.95	0	No	No	Yes	No	5	5
104	3x52	I2x53	cb2_on	1.95	0	No	No	Yes	Yes	5	7
105	NT.D24	NT.Y25	cb2_on	1.91667	0	No	No	No	No	4	4
106	I1.R66	I1x48	cb2_on	1.88167	0	No	No	No	No	7	5
107	I1x48	I1x51	cb2_on	1.88167	0	No	No	No	No	5	3
108	6x28	6x30	cb2_on	1.78667	0	No	Yes	Yes	No	4	7
109	4x39	4x40	cb2_on	1.75	0	No	No	No	No	3	4
110	4x52	5x46	cb2_on	1.625	0	No	No	No	No	4	5
111	1x58	I1x51	cb2_on	1.61833	0	No	No	No	No	4	3
112	3x54	5x65	cb2_on	1.58	0	No	No	No	No	9	8
113	5x65	6x33	cb2_on	1.58	0	No	No	No	No	8	7
114	E2.P176	E2.W172	cb2_on	1.57667	0	No	No	Yes	Yes	4	5
115	1x43	1x46	cb2_on	1.55	0	No	No	No	No	7	7
116	2x46	3x39	cb2_on	1.5	0	Yes	No	No	No	9	9
117	3x44	5x53	cb2_on	1.425	0	Yes	No	No	No	6	5
118	6x45	6x49	cb2_on	1.42	0	No	No	No	No	6	5
119	E1.D101	E1.G99	cb2_on	1.39667	0	No	No	No	No	2	5
120	3x56	I2x50	cb2_on	1.39	0	Yes	No	No	No	5	8
121	5x44	6x56	cb2_on	1.31667	0	No	No	No	No	4	5
122	5x49	5x50	cb2_on	1.22	0	No	No	Yes	No	4	7
123	4x62	4x63	cb2_on	1.16667	0	No	No	No	No	4	4
124	3x21	3x23	cb2_on	1.14	0	No	No	No	No	6	1
125	I3.M234	I3.Q230	cb2_on	1.13333	0	No	No	No	No	0	0
126	8x51	8x55	cb2_on	1.13	0	No	No	No	No	8	4
127	1x55	8x57	cb2_on	1.12	0	No	No	No	No	5	0
128	NT.M22	NT.P21	cb2_on	1.11833	0	Yes	No	No	No	7	0
129	5x72	I3.Q227	cb2_on	1.10833	0	No	No	No	No	6	2
130	7x27	E3.T272	cb2_on	1.06667	0	No	No	No	No	2	1
131	5x39	5x42	cb2_on	1.06	0	Yes	Yes	No	No	7	5
132	4x38	4x40	cb2_on	0.91	0	No	No	No	No	9	4
133	5x68	5x72	cb2_on	0.858333	0	No	Yes	No	No	7	6
134	4x46	4x47	cb2_on	0.855	0	Yes	No	No	No	8	4
135	1x40	2x62	cb2_on	0.795	0	No	No	No	No	5	5
136	4x44	4x48	cb2_on	0.77	0	No	No	No	No	3	3
137	4x55	4x56	cb2_on	0.745	0	No	No	No	No	3	5
138	8x49	8x52	cb2_on	0.72	0	Yes	Yes	No	No	6	4
139	8x52	8x56	cb2_on	0.696667	0	No	No	No	No	4	5
140	1x41	1x42	cb2_on	0.691667	0	No	No	Yes	No	4	6
141	I3.P232	I3.V231	cb2_on	0.588333	0	No	No	No	No	0	0
142	5x70	5x73	cb2_on	0.57	0	No	No	Yes	No	5	4
143	1x33	1x34	cb2_on	0.56	0	No	No	No	No	4	5
144	6x46	6x47	cb2_on	0.546667	0	No	No	No	No	5	8
145	5x69	5x73	cb2_on	0.54	0	No	No	Yes	No	5	4
146	E1.V100	NT.M22	cb2_on	0.506667	0	No	No	Yes	No	4	7
147	5x71	I3.H226	cb2_on	0.465	0	No	No	No	No	3	4
148	1x34	7x36	cb2_on	0.461667	0	No	No	No	No	5	4
149	1x45	1x48	cb2_on	0.46	0	No	No	No	No	4	4
150	8x55	8x58	cb2_on	0.428333	0	No	No	No	No	4	0
151	5x52	5x53	cb2_on	0.31	0	No	No	No	No	3	5
152	5x73	5x74	cb2_on	0.31	0	Yes	No	No	No	4	4
153	6x42	6x46	cb2_on	0.27	0	No	No	No	No	5	5
154	5x73	I3.V231	cb2_on	0.27	0	Yes	No	No	No	4	0
155	7x29	7x33	cb2_on	0.253333	0	No	No	No	No	3	3
156	I3.P232	I3.R229	cb2_on	0.24	0	No	No	No	No	0	0
157	I3.D228	I3.R229	cb2_on	0.198333	0	No	No	No	No	0	0
158	E2.P184	NT.Y25	Shared	12.5167	23.64	No	No	No	No	5	4
159	2x64	NT.M26	Shared	6.01167	9.95	Yes	Yes	No	No	3	6
160	E1.H98	NT.M26	Shared	4.59667	7.88	No	No	No	No	4	6
161	7x31	NT.I27	Shared	7.27	4.36	No	No	No	No	2	5
162	1x29	1x30	Shared	4.06	4.06	No	No	No	No	4	4
163	1x36	2x66	Shared	3.95833	3.39	No	No	Yes	Yes	5	4
164	1x38	1x42	Shared	3.69	5.54	No	No	Yes	No	5	6
165	1x39	2x61	Shared	3.26	4.19	No	No	Yes	Yes	6	6
166	1x39	7x39	Shared	4.32	4.86	No	No	No	No	6	5
167	1x45	7x47	Shared	4.475	4.24	No	No	Yes	No	4	6
168	1x46	2x54	Shared	5.43333	6.52	No	No	No	No	7	8
169	1x46	7x47	Shared	4.09	3.07	No	No	Yes	No	7	6
170	1x47	2x51	Shared	3.00167	2.77	No	No	Yes	Yes	6	7
171	1x49	7x47	Shared	3.15667	6.77	No	Yes	Yes	No	8	6
172	1x49	7x50	Shared	5.5	7.86	No	Yes	No	No	8	9
173	1x50	2x50	Shared	11.22	6.73	No	No	No	Yes	9	9
174	1x50	7x50	Shared	5.97667	4.89	No	No	No	No	9	9
175	1x51	2x51	Shared	4.58833	2.62	No	No	Yes	Yes	5	7
176	1x55	1x59	Shared	11.2333	11.45	No	No	No	No	5	5
177	1x56	8x53	Shared	3.00167	4.5	No	No	No	No	8	7
178	1x60	I1x50	Shared	8.76	6.01	No	No	No	No	7	8
179	2x40	I1x50	Shared	6.83833	10.55	Yes	Yes	No	No	8	8
180	2x37	2x40	Shared	8.75833	4.78	No	No	Yes	Yes	6	8
181	2x37	8x49	Shared	4.275	6.75	No	No	Yes	Yes	6	6
182	2x40	8x47	Shared	8.05333	3.82	Yes	Yes	No	No	8	8
183	2x40	8x49	Shared	9.165	15.71	Yes	Yes	Yes	Yes	8	6
184	2x40	8x50	Shared	5.23833	4.84	Yes	Yes	No	Yes	8	8
185	2x41	4x43	Shared	3.46	1.38	No	No	No	No	4	1
186	2x42	3x49	Shared	4.77667	9.55	Yes	No	Yes	Yes	8	9
187	2x42	4x46	Shared	3.855	3.65	Yes	No	Yes	No	8	8
188	2x45	3x42	Shared	4.34667	4.89	No	No	No	No	9	8
189	2x45	4x46	Shared	9.01	9.01	No	No	Yes	No	9	8
190	2x45	4x50	Shared	4.53333	6.18	No	No	Yes	No	9	9
191	2x46	3x43	Shared	5.07667	2.77	Yes	No	No	No	9	8
192	2x46	7x49	Shared	3.66167	4.12	Yes	No	No	No	9	9
193	2x50	7x46	Shared	8.34333	7.36	No	Yes	No	No	9	9
194	2x51	2x55	Shared	3.93167	3.93	Yes	Yes	No	No	7	4
195	2x52	3x35	Shared	3.685	2.95	No	No	No	No	7	7
196	2x53	3x35	Shared	3.63833	3.36	No	No	No	No	8	7
197	2x57	2x61	Shared	5.535	3.22	Yes	No	Yes	Yes	6	6
198	2x57	Lig	Shared	9.50167	10.25	Yes	No	Yes	Yes	6	0
199	2x60	Lig	Shared	3.765	3.16	No	No	Yes	Yes	4	0
200	2x61	2x65	Shared	13.1983	12.44	Yes	Yes	Yes	No	6	4
201	2x61	Lig	Shared	3.83667	3.42	Yes	Yes	Yes	Yes	6	0
202	2x62	2x66	Shared	3.205	4.81	No	No	Yes	Yes	5	4
203	2x64	3x25	Shared	3.93	3.22	Yes	Yes	Yes	Yes	3	9
204	2x64	Lig	Shared	10.8033	6.83	Yes	Yes	Yes	Yes	3	0
205	3x28	E1.D101	Shared	3.91833	12.44	No	No	No	No	5	2
206	3x21	3x24	Shared	4.31167	3.23	No	No	No	No	6	4
207	3x22	E2.L185	Shared	4.23	5.64	No	No	No	No	3	4
208	3x25	3x29	Shared	6.28	3.77	Yes	Yes	No	Yes	9	4
209	3x25	E2.P184	Shared	5.535	8.67	Yes	Yes	No	No	9	5
210	3x26	4x61	Shared	3.22667	2.77	No	No	Yes	No	5	6
211	3x29	Lig	Shared	6.57167	5	No	Yes	Yes	Yes	4	0
212	3x31	4x58	Shared	3.81833	5.09	No	No	Yes	No	4	4
213	3x32	Lig	Shared	3.89167	5.22	No	No	Yes	Yes	5	0
214	3x33	4x57	Shared	5.06333	6.4	No	No	No	No	4	7
215	3x33	5x43	Shared	4.64667	4.85	No	No	Yes	Yes	4	5
216	3x33	Lig	Shared	10.9667	5.17	No	No	Yes	Yes	4	0
217	3x34	4x57	Shared	5.11	4.6	Yes	No	No	No	5	7
218	3x34	4x58	Shared	9.38	5.99	Yes	No	Yes	No	5	4
219	3x36	6x48	Shared	7.685	4.01	Yes	No	Yes	Yes	6	8
220	3x36	Lig	Shared	3.99833	10.25	Yes	No	Yes	Yes	6	0
221	3x37	4x53	Shared	3.73333	4.8	No	No	No	No	6	8
222	3x37	5x43	Shared	6.06333	3.64	No	No	Yes	Yes	6	5
223	3x38	4x50	Shared	7.34667	7.78	No	No	Yes	No	7	9
224	3x38	4x53	Shared	3.42	3.42	No	No	No	No	7	8
225	3x40	5x50	Shared	3.97333	5.96	No	No	Yes	No	8	7
226	3x40	5x51	Shared	5.67833	3.93	No	No	Yes	No	8	7
227	3x41	4x49	Shared	4.075	3.49	No	No	No	No	5	6
228	3x43	6x44	Shared	2.99667	2.77	No	No	No	No	8	9
229	3x44	3x48	Shared	3.33	2.85	Yes	No	No	No	6	6
230	3x45	4x49	Shared	5.18167	4.24	No	No	No	No	6	6
231	3x49	I2x53	Shared	9.96167	8.05	Yes	Yes	Yes	Yes	9	7
232	3x49	I2x57	Shared	6.335	5.43	Yes	Yes	No	No	9	6
233	3x51	3x55	Shared	11.8333	13.38	No	No	No	No	8	6
234	3x51	5x57	Shared	3.33	2.5	No	No	No	No	8	6
235	3x53	I2x53	Shared	8.06333	4.03	No	No	Yes	Yes	8	7
236	3x55	3x56	Shared	20.5767	19.55	No	No	Yes	No	6	5
237	3x55	5x64	Shared	5.36167	2.48	No	No	No	No	6	6
238	I2x50	I2x51	Shared	7.465	5.84	No	No	No	No	8	7
239	4x38	4x41	Shared	4.74167	11.64	No	No	No	No	9	6
240	4x56	5x46	Shared	7.64833	5.24	No	No	No	No	5	5
241	4x60	5x39	Shared	12.285	12.52	No	No	Yes	Yes	5	7
242	E2.C175	E2.T173	Shared	3.38	1.69	No	No	No	Yes	3	5
243	E2.C174	E2.C179	Shared	7.28	7.28	No	No	No	No	5	9
244	5x36	E2.C174	Shared	4.08	5.65	Yes	Yes	No	No	4	5
245	E2.P178	E2.R177	Shared	3.6	2.88	No	No	No	Yes	4	3
246	5x38	E2.R177	Shared	6.35333	10.72	No	No	No	Yes	4	3
247	5x37	E2.S180	Shared	3.22833	4.47	No	No	No	No	4	4
248	7x31	E2.E181	Shared	4.05	9.45	No	No	No	No	2	4
249	6x58	E2.L182	Shared	7.50833	4.5	No	No	No	No	3	4
250	7x34	E2.L182	Shared	9.135	14.61	Yes	No	No	No	4	4
251	E2.F183	Lig	Shared	26.8867	21.35	Yes	No	Yes	Yes	6	0
252	5x36	E2.I186	Shared	3.95333	3.39	Yes	Yes	Yes	Yes	4	5
253	E2.I186	Lig	Shared	3.345	5	Yes	Yes	Yes	Yes	5	0
254	5x41	6x59	Shared	5.075	4.15	No	No	No	No	4	3
255	5x43	5x47	Shared	11.7433	10.57	Yes	Yes	No	No	5	7
256	5x43	Lig	Shared	13.5167	10.38	Yes	Yes	Yes	Yes	5	0
257	5x44	6x55	Shared	5.18	2.83	No	No	Yes	No	4	6
258	5x46	5x50	Shared	5.48167	10.96	No	No	Yes	No	5	7
259	5x47	5x51	Shared	4.605	2.51	No	No	Yes	No	7	7
260	5x55	6x41	Shared	3.32833	2.85	No	No	No	No	5	7
261	5x56	5x60	Shared	8.71167	15.24	No	No	No	No	4	5
262	5x58	6x37	Shared	9.965	3.52	Yes	Yes	No	No	9	8
263	5x58	6x41	Shared	7.23	3.52	Yes	Yes	No	No	9	7
264	5x63	5x67	Shared	5.84333	4.38	No	No	No	No	3	5
265	6x36	7x56	Shared	12.7183	9.06	No	No	No	No	8	7
266	6x39	7x56	Shared	4.65667	6.07	No	No	No	No	6	7
267	6x40	7x53	Shared	7.57	3.79	No	No	Yes	Yes	8	9
268	6x44	6x48	Shared	3.23	4.56	No	No	Yes	Yes	9	8
269	6x47	7x45	Shared	7.87167	7.87	No	No	No	No	8	9
270	6x48	7x41	Shared	7.40333	3.92	Yes	Yes	No	No	8	7
271	6x49	6x50	Shared	3.12667	4.33	No	No	No	No	5	9
272	6x54	7x34	Shared	5.48167	3.65	No	No	Yes	No	4	4
273	6x57	6x61	Shared	3.19667	6.85	No	No	No	No	4	3
274	7x30	E3.L273	Shared	3.725	2.98	No	No	No	Yes	3	1
275	7x38	Lig	Shared	7.33333	3.16	No	No	Yes	Yes	5	0
276	7x48	7x52	Shared	4.09667	3.07	No	No	Yes	No	6	9
277	8x47	8x50	Shared	5.67333	9.29	No	No	No	Yes	8	8
278	2x56	3x31	Shared	3.23167	1.62	No	No	No	No	4	4
279	2x64	2x65	Shared	7.35167	6.79	Yes	Yes	Yes	No	3	4
280	3x29	E2.I186	Shared	3.435	5.89	No	Yes	Yes	Yes	4	5
281	3x44	5x54	Shared	4.04333	5.71	Yes	No	No	No	6	8
282	4x59	E2.W172	Shared	4.175	5.69	No	No	Yes	Yes	5	5
283	5x39	E2.W172	Shared	4.66167	9.65	Yes	Yes	Yes	Yes	7	5
284	E2.E181	E3.T272	Shared	4.23333	1.41	No	No	No	No	4	1
285	E2.E181	E3.L273	Shared	5.52167	5.3	No	No	No	Yes	4	1
286	E2.F183	E2.L182	Shared	4.265	3.65	Yes	No	No	No	6	4
287	5x37	6x59	Shared	3.43333	5.49	No	No	No	No	4	3
288	5x64	5x67	Shared	3.39167	6.78	No	No	No	No	6	5
289	3x25	NT.M22	Shared	3.31833	12.44	Yes	Yes	Yes	No	9	7
290	7x32	NT.I27	Shared	2.90833	4.36	No	No	No	No	2	5
291	3x30	4x58	Shared	2.9	4.35	No	No	Yes	No	6	4
292	4x39	I1x51	Shared	2.84333	1.07	No	No	No	No	3	3
293	E2.C175	E2.P176	Shared	2.82167	3.77	No	No	No	No	3	4
294	6x57	E3.L273	Shared	2.785	2.57	No	No	No	Yes	4	1
295	2x42	4x42	Shared	2.77167	2.77	Yes	No	No	No	8	7
296	6x49	6x53	Shared	2.77167	2.77	No	No	No	No	5	5
297	3x27	4x61	Shared	2.76667	1.38	No	No	Yes	No	4	6
298	1x60	8x53	Shared	2.71667	4.89	No	No	No	No	7	7
299	1x56	8x54	Shared	2.62667	3.15	No	No	No	No	8	6
300	1x35	7x36	Shared	2.62	3.93	No	No	No	No	5	4
301	4x61	4x62	Shared	2.59	1.41	Yes	No	No	No	6	4
302	1x53	2x47	Shared	2.545	3.39	No	No	No	No	9	9
303	7x51	7x55	Shared	2.48333	1.49	No	No	No	No	6	6
304	3x24	E1.D101	Shared	2.43333	5.84	No	No	No	No	4	2
305	E2.R177	E2.W172	Shared	2.33167	8	No	Yes	Yes	Yes	3	5
306	3x56	I2x52	Shared	2.33	1.27	Yes	No	No	No	5	5
307	6x28	6x32	Shared	2.31	3.49	No	Yes	No	No	4	8
308	6x30	I3.M237	Shared	2.30833	5.54	Yes	No	No	No	7	4
309	1x55	8x61	Shared	2.25	4.82	No	No	No	No	5	0
310	6x50	7x40	Shared	2.18667	1.64	No	No	No	No	9	8
311	2x66	E1.F97	Shared	2.185	5.24	Yes	Yes	No	No	4	3
312	8x58	8x62	Shared	2.115	2.82	No	No	No	No	0	0
313	1x54	2x47	Shared	2.10333	3.15	No	No	No	No	7	9
314	2x40	2x43	Shared	2.01667	3.63	Yes	Yes	No	No	8	8
315	2x44	2x47	Shared	1.95	1.95	No	No	No	No	7	9
316	1x49	7x51	Shared	1.90167	1.43	No	Yes	No	No	8	6
317	3x34	4x54	Shared	1.87833	3.22	Yes	No	No	No	5	3
318	5x41	5x45	Shared	1.845	2.77	No	No	No	No	4	3
319	1x32	2x66	Shared	1.77167	9.11	Yes	No	Yes	Yes	5	4
320	6x54	7x37	Shared	1.58667	3.17	No	No	No	No	4	4
321	4x45	4x48	Shared	1.52	1.43	No	No	No	No	6	3
322	2x65	7x35	Shared	1.465	1.46	Yes	No	No	No	4	4
323	1x43	2x58	Shared	1.3	1.95	No	No	No	No	7	6
324	1x44	1x48	Shared	1.15167	2.77	No	No	No	No	5	4
325	7x55	8x51	Shared	1.01167	3.64	No	No	No	No	6	8
326	6x60	6x61	Shared	0.84	1.68	No	No	No	No	4	3
327	1x37	1x41	Shared	0.745	1.49	No	No	No	No	5	4
328	2x55	2x59	Shared	0.57	1.71	No	No	No	No	4	7
329	5x39	Lig	cb2_off	0	3.29	Yes	Yes	Yes	Yes	7	0
330	6x48	Lig	cb2_off	0	7.98	Yes	Yes	Yes	Yes	8	0
331	6x51	Lig	cb2_off	0	3.13	No	No	Yes	Yes	6	0
332	6x55	Lig	cb2_off	0	5.95	Yes	No	Yes	Yes	6	0
333	7x41	Lig	cb2_off	0	3.34	No	No	Yes	Yes	7	0
334	NT.P20	NT.Y25	cb2_off	0	6.95	No	Yes	No	No	0	4
335	E2.C179	NT.P20	cb2_off	0	3.77	No	No	No	Yes	9	0
336	NT.K23	NT.P21	cb2_off	0	6.69	No	No	No	No	4	0
337	NT.D24	NT.P21	cb2_off	0	9.66	No	No	No	No	4	0
338	NT.D24	NT.K23	cb2_off	0	6.91	No	No	No	No	4	4
339	7x28	NT.I27	cb2_off	0	7	No	No	No	No	3	5
340	1x32	NT.L28	cb2_off	0	7.05	Yes	No	No	No	5	6
341	E1.H98	NT.L28	cb2_off	0	7.71	No	No	No	No	4	6
342	1x28	1x31	cb2_off	0	7.22	No	No	No	No	7	5
343	1x28	7x32	cb2_off	0	4.59	No	No	No	No	7	2
344	1x32	1x33	cb2_off	0	6.01	Yes	No	No	No	5	4
345	1x35	2x61	cb2_off	0	3.93	No	No	Yes	Yes	5	6
346	1x38	7x39	cb2_off	0	7.07	No	No	No	No	5	5
347	1x43	7x42	cb2_off	0	3.42	No	No	No	No	7	6
348	1x45	1x49	cb2_off	0	3.98	No	No	No	Yes	4	8
349	1x46	7x46	cb2_off	0	3.26	No	No	No	No	7	9
350	8x49	I1x49	cb2_off	0	5.1	Yes	Yes	No	No	6	6
351	4x39	I1.R66	cb2_off	0	6.4	No	No	No	No	3	7
352	2x38	I2x53	cb2_off	0	4.17	No	No	Yes	Yes	5	7
353	2x39	2x40	cb2_off	0	5.09	No	No	Yes	Yes	8	8
354	2x39	3x50	cb2_off	0	5.27	No	No	No	Yes	8	9
355	2x40	6x33	cb2_off	0	5.86	Yes	Yes	No	No	8	7
356	2x43	7x53	cb2_off	0	8.46	No	No	Yes	Yes	8	9
357	2x46	2x50	cb2_off	0	5.43	Yes	No	No	Yes	9	9
358	2x48	2x52	cb2_off	0	6.92	No	No	No	No	7	7
359	2x49	3x39	cb2_off	0	3.42	No	No	No	No	8	9
360	2x50	3x39	cb2_off	0	4.42	No	Yes	No	No	9	9
361	2x63	E1.G99	cb2_off	0	3.39	No	No	No	No	3	5
362	3x26	E2.T173	cb2_off	0	4.42	No	No	No	Yes	5	5
363	3x29	E2.F183	cb2_off	0	3.77	No	Yes	Yes	No	4	6
364	3x37	4x57	cb2_off	0	3.2	No	No	No	No	6	7
365	3x42	4x49	cb2_off	0	3.07	No	No	No	No	8	6
366	3x49	3x50	cb2_off	0	4.76	Yes	Yes	No	Yes	9	9
367	3x50	6x30	cb2_off	0	3.57	No	Yes	Yes	No	9	7
368	3x50	6x33	cb2_off	0	8.5	No	Yes	No	No	9	7
369	3x53	6x30	cb2_off	0	6.22	No	No	Yes	No	8	7
370	3x54	5x68	cb2_off	0	7.71	No	No	No	Yes	9	7
371	I2x53	I2x57	cb2_off	0	14.07	Yes	Yes	No	No	7	6
372	4x59	5x39	cb2_off	0	5.86	No	No	Yes	Yes	5	7
373	4x60	E2.I186	cb2_off	0	3.39	No	No	Yes	Yes	5	5
374	5x38	E2.W172	cb2_off	0	10.05	No	No	Yes	Yes	4	5
375	5x36	E2.R177	cb2_off	0	4.32	Yes	Yes	No	Yes	4	3
376	E2.I186	E2.S180	cb2_off	0	3.1	Yes	Yes	No	No	5	4
377	5x36	5x38	cb2_off	0	3.22	Yes	Yes	No	No	4	4
378	5x40	6x59	cb2_off	0	6.92	No	No	No	No	5	3
379	5x51	6x45	cb2_off	0	4.87	Yes	No	No	No	7	6
380	5x58	5x61	cb2_off	0	5.05	Yes	Yes	No	No	9	9
381	5x58	5x62	cb2_off	0	10.55	Yes	Yes	No	No	9	6
382	5x58	6x38	cb2_off	0	5.79	Yes	Yes	No	No	9	6
383	5x60	5x63	cb2_off	0	3.17	No	No	No	No	5	3
384	5x63	5x64	cb2_off	0	3.48	No	No	No	No	3	6
385	5x68	I3.R236	cb2_off	0	9.03	No	Yes	No	No	7	0
386	5x68	6x31	cb2_off	0	4.15	No	Yes	No	No	7	5
387	5x69	I3.A235	cb2_off	0	3.39	No	No	No	No	5	0
388	6x28	6x29	cb2_off	0	3.64	No	Yes	No	Yes	4	5
389	6x28	8x48	cb2_off	0	8.14	No	Yes	No	No	4	4
390	6x29	6x32	cb2_off	0	5.3	No	Yes	No	No	5	8
391	6x29	8x48	cb2_off	0	5.3	No	Yes	No	No	5	4
392	6x29	8x49	cb2_off	0	5.3	No	Yes	Yes	Yes	5	6
393	6x32	8x48	cb2_off	0	10.15	No	No	No	No	8	4
394	6x35	7x56	cb2_off	0	4.95	No	No	No	No	7	7
395	6x40	7x49	cb2_off	0	5.91	No	No	No	No	8	9
396	6x43	7x48	cb2_off	0	6.41	No	No	No	No	7	6
397	6x44	7x45	cb2_off	0	5.49	No	No	No	No	9	9
398	6x47	7x43	cb2_off	0	3.27	No	No	No	No	8	4
399	6x48	6x52	cb2_off	0	3.42	Yes	Yes	No	No	8	6
400	6x51	7x41	cb2_off	0	3.42	No	No	No	No	6	7
401	7x27	7x29	cb2_off	0	5.78	No	No	No	No	2	3
402	7x53	8x50	cb2_off	0	3.63	Yes	Yes	No	Yes	9	8
403	8x50	8x53	cb2_off	0	3.1	No	Yes	No	No	8	7
404	3x48	5x57	cb2_off	0	3.04	No	No	No	No	6	6
405	2x54	7x42	cb2_off	0	3	No	No	No	No	8	6
406	3x22	E2.T173	cb2_off	0	3	No	No	No	Yes	3	5
407	6x58	E3.L273	cb2_off	0	3	No	No	No	Yes	3	1
408	1x57	2x43	cb2_off	0	2.94	No	No	No	No	8	8
409	7x29	7x30	cb2_off	0	2.87	No	No	No	No	3	3
410	3x48	3x52	cb2_off	0	2.85	No	No	No	No	6	5
411	4x48	4x52	cb2_off	0	2.85	No	No	No	No	3	4
412	5x54	6x41	cb2_off	0	2.85	No	No	No	No	8	7
413	3x50	6x34	cb2_off	0	2.77	No	Yes	No	No	9	8
414	5x68	I3.M237	cb2_off	0	2.63	No	Yes	No	No	7	4
415	3x50	5x61	cb2_off	0	2.62	No	Yes	No	No	9	9
416	6x36	7x53	cb2_off	0	2.5	No	No	Yes	Yes	8	9
417	5x42	E2.W172	cb2_off	0	2.47	No	No	Yes	Yes	5	5
418	2x51	2x52	cb2_off	0	2.44	Yes	Yes	No	No	7	7
419	3x25	E1.D101	cb2_off	0	2.39	Yes	Yes	No	No	9	2
420	2x48	4x50	cb2_off	0	2.28	No	No	Yes	No	7	9
421	NT.P20	NT.P21	cb2_off	0	1.95	No	Yes	No	No	0	0
422	6x50	7x37	cb2_off	0	1.88	No	No	No	No	9	4
423	NT.A19	NT.P20	cb2_off	0	1.87	No	No	No	Yes	0	0
424	1x53	7x50	cb2_off	0	1.77	No	No	No	No	9	9
425	E1.G99	NT.M26	cb2_off	0	1.75	No	No	No	No	5	6
426	1x30	1x33	cb2_off	0	1.75	No	No	No	No	4	4
427	4x60	E2.T173	cb2_off	0	1.75	No	No	No	Yes	5	5
428	1x59	8x57	cb2_off	0	1.72	No	No	No	No	5	0
429	1x60	8x57	cb2_off	0	1.72	No	No	No	No	7	0
430	6x43	6x47	cb2_off	0	1.71	No	No	No	No	7	8
431	5x65	6x31	cb2_off	0	1.7	No	No	No	No	8	5
432	3x46	6x37	cb2_off	0	1.58	No	No	No	No	9	8
433	3x47	6x37	cb2_off	0	1.58	No	No	No	No	9	8
434	I2x55	I2x56	cb2_off	0	1.58	No	No	No	No	4	4
435	I2x56	I2x57	cb2_off	0	1.38	No	No	No	No	4	6
436	6x28	I3.A235	cb2_off	0	1.38	No	Yes	No	No	4	0
437	I1x48	I1x49	cb2_off	0	1.24	No	No	No	No	5	6
438	5x45	5x49	cb2_off	0	1.22	No	No	No	No	3	4
439	2x41	4x39	cb2_off	0	1.21	No	No	No	No	4	3

Orange: nodes, hubs and links specific of cb2_on network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of cb2_off network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	cb2_on Avg Int. Strength	cb2_off Avg Int. Strength	cb2_on Num Of Links	cb2_off Num Of Links	ConSurf
1	NT.M22	cb2_on	2.24933	12.44	5	1	7
2	1x32	cb2_on	2.71667	7.39	4	3	5
3	1x42	cb2_on	3.13033	5.54	5	1	6
4	2x42	cb2_on	5.23583	5.32333	4	3	8
5	2x46	cb2_on	3.96967	4.10667	5	3	9
6	2x57	cb2_on	5.82611	6.735	6	2	6
7	2x65	cb2_on	6.46792	6.89667	4	3	4
8	3x34	cb2_on	4.86792	4.60333	4	3	5
9	3x36	cb2_on	5.15767	7.13	5	2	6
10	3x44	cb2_on	2.89125	4.28	4	2	6
11	3x56	cb2_on	5.87433	10.41	5	2	5
12	4x46	cb2_on	4.56875	6.33	4	2	8
13	4x50	cb2_on	4.469	5.41333	5	3	9
14	4x58	cb2_on	4.70792	5.14333	4	3	4
15	4x61	cb2_on	2.82917	1.85333	4	3	6
16	E2.F183	cb2_on	9.07533	9.59	5	3	6
17	5x50	cb2_on	3.36042	8.46	4	2	7
18	5x51	cb2_on	5.04	3.77	5	3	7
19	5x73	cb2_on	0.4225	0	4	0	4
20	6x30	cb2_on	5.04375	5.11	4	3	7
21	6x55	cb2_on	4.28792	4.39	4	2	6
22	7x34	cb2_on	5.95267	9.13	5	2	4
23	7x47	cb2_on	4.10792	4.69333	4	3	6
24	7x52	cb2_on	3.40375	3.07	4	1	9
25	2x40	Shared	6.67833	6.785	6	8	8
26	2x51	Shared	4.03833	2.94	4	4	7
27	2x61	Shared	5.87067	5.44	5	5	6
28	2x64	Shared	6.24167	6.6975	5	4	3
29	2x66	Shared	2.78	5.6375	4	4	4
30	3x25	Shared	4.34033	6.098	5	5	9
31	3x49	Shared	6.8025	6.9475	4	4	9
32	I2x53	Shared	6.03875	7.58	4	4	7
33	E2.W172	Shared	4.21533	7.172	5	5	5
34	E2.I186	Shared	3.58567	4.154	5	5	5
35	5x36	Shared	4.84417	4.145	4	4	4
36	5x39	Shared	4.90444	7.83	6	4	7
37	5x43	Shared	7.47139	7.36	6	4	5
38	5x58	Shared	6.25556	5.686	6	5	9
39	6x48	Shared	5.96722	4.778	6	5	8
40	7x53	Shared	5.45238	4.595	7	4	9
41	8x49	Shared	4.645	8.215	4	4	6
42	Lig	Shared	8.31012	6.64	14	17	0
43	NT.P20	cb2_off	0	3.635	0	4	0
44	1x49	cb2_off	3.51944	5.01	3	4	8
45	2x50	cb2_off	7.79222	5.985	3	4	9
46	3x29	cb2_off	5.42889	4.6075	3	4	4
47	3x50	cb2_off	6.00778	4.58167	3	6	9
48	E2.T173	cb2_off	3.38	2.715	1	4	5
49	E2.R177	cb2_off	4.095	6.48	3	4	3
50	5x68	cb2_off	1.5	5.88	2	4	7
51	6x28	cb2_off	2.02	4.1625	3	4	4
52	6x29	cb2_off	2.64778	4.885	3	4	5
53	E3.L273	cb2_off	4.01056	3.4625	3	4	1
54	8x50	cb2_off	4.35833	5.215	3	4	8

Orange: nodes, hubs and links specific of cb2_on network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of cb2_off network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	cb2_on Recurrence	cb2_off Recurrence	cb2_on Hub1?	cb2_off Hub1?	cb2_on Hub2?	cb2_off Hub2?	ConSurf1	ConSurf2
1	7x32	NT.I27	cb2_on	34.5917	6.15634	No	No	No	No	2	5
2	7x32	NT.L28	cb2_on	43.8394	0	No	No	No	No	2	6
3	2x65	NT.L28	cb2_on	62.0935	0	Yes	No	No	No	4	6
4	2x64	2x65	cb2_on	28.784	4.8336	Yes	Yes	Yes	No	3	4
5	1x31	NT.L28	cb2_on	15.8551	0	No	No	No	No	5	6
6	1x32	E1.H98	cb2_on	14.9169	0	Yes	No	No	No	5	4
7	1x31	7x36	cb2_on	12.701	0	No	No	No	No	5	4
8	1x42	7x42	cb2_on	23.1728	0	Yes	No	No	No	6	6
9	2x57	7x42	cb2_on	24.4594	0	Yes	No	No	No	6	6
10	2x57	Lig	cb2_on	17.1506	1.94188	Yes	No	Yes	Yes	6	0
11	2x61	2x65	cb2_on	39.4434	4.55217	Yes	Yes	Yes	No	6	4
12	1x42	7x47	cb2_on	16.7396	0	Yes	No	Yes	No	6	6
13	2x50	7x49	cb2_on	25.1608	0	No	Yes	No	No	9	9
14	7x45	7x49	cb2_on	22.9092	0	No	No	No	No	9	9
15	6x48	7x45	cb2_on	26.166	0	Yes	Yes	No	No	8	9
16	3x36	6x48	cb2_on	63.7107	1.46345	Yes	No	Yes	Yes	6	8
17	3x36	Lig	cb2_on	51.5994	1.45641	Yes	No	Yes	Yes	6	0
18	1x49	7x47	cb2_on	13.3444	0.408077	No	Yes	Yes	No	8	6
19	1x53	7x54	cb2_on	10.4762	0	No	No	No	No	9	8
20	7x54	8x50	cb2_on	12.1917	0	No	No	No	Yes	8	8
21	2x37	2x40	cb2_on	36.6824	3.72194	No	No	Yes	Yes	6	8
22	2x37	2x38	cb2_on	61.9728	0	No	No	No	No	6	5
23	2x38	I2x57	cb2_on	63.3846	0	No	No	No	No	5	6
24	3x49	I2x57	cb2_on	64.8454	8.6048	Yes	Yes	No	No	9	6
25	4x46	4x50	cb2_on	64.7561	0	Yes	No	Yes	No	8	9
26	3x34	4x50	cb2_on	57.2686	0	Yes	No	Yes	No	5	9
27	1x55	8x57	cb2_on	16.7843	0	No	No	No	No	5	0
28	1x56	8x57	cb2_on	19.7105	0	No	No	No	No	8	0
29	1x56	8x53	cb2_on	26.3581	4.70696	No	No	No	No	8	7
30	1x60	8x53	cb2_on	29.664	6.81067	No	No	No	No	7	7
31	1x60	I1x50	cb2_on	36.602	4.72807	No	No	No	No	7	8
32	2x40	I1x50	cb2_on	20.2689	8.40779	Yes	Yes	No	No	8	8
33	8x49	I1x50	cb2_on	19.5184	0	Yes	Yes	No	No	6	8
34	2x37	8x49	cb2_on	23.8921	0.0492507	No	No	Yes	Yes	6	6
35	4x39	4x43	cb2_on	14.6221	0	No	No	No	No	3	1
36	2x41	4x43	cb2_on	16.1455	0.0211074	No	No	No	No	4	1
37	2x41	4x42	cb2_on	17.7314	0	No	No	No	No	4	7
38	2x42	4x42	cb2_on	19.4023	2.58918	Yes	No	No	No	8	7
39	2x42	3x45	cb2_on	10.7711	0	Yes	No	No	No	8	6
40	2x45	3x42	cb2_on	43.6026	8.91437	No	No	No	No	9	8
41	2x46	3x42	cb2_on	44.4916	0	Yes	No	No	No	9	8
42	3x43	7x53	cb2_on	45.4968	0	No	No	Yes	Yes	8	9
43	2x60	Lig	cb2_on	11.0704	1.84338	No	No	Yes	Yes	4	0
44	3x34	4x58	cb2_on	14.2289	8.85809	Yes	No	Yes	No	5	4
45	3x40	6x48	cb2_on	21.2607	0	No	No	Yes	Yes	8	8
46	3x40	5x50	cb2_on	31.4734	6.02266	No	No	Yes	No	8	7
47	3x44	5x50	cb2_on	14.5595	0	Yes	No	Yes	No	6	7
48	3x47	5x58	cb2_on	15.0688	0	No	No	Yes	Yes	9	9
49	5x58	7x53	cb2_on	58.5686	0	Yes	Yes	Yes	Yes	9	9
50	3x47	5x57	cb2_on	13.9251	0	No	No	No	No	9	6
51	3x49	I2x53	cb2_on	14.7695	6.81067	Yes	Yes	Yes	Yes	9	7
52	3x54	5x61	cb2_on	39.5952	0	No	No	No	No	9	9
53	5x61	6x37	cb2_on	41.0874	0	No	No	No	No	9	8
54	5x58	6x37	cb2_on	45.403	8.61183	Yes	Yes	No	No	9	8
55	3x52	I2x53	cb2_on	10.6281	0	No	No	Yes	Yes	5	7
56	5x46	5x50	cb2_on	11.3965	3.98931	No	No	Yes	No	5	7
57	5x39	5x43	cb2_on	22.8645	0	Yes	Yes	Yes	Yes	7	5
58	5x39	E2.W172	cb2_on	19.2593	8.55555	Yes	Yes	Yes	Yes	7	5
59	5x40	E2.S180	cb2_on	12.6162	0	No	No	No	No	5	4
60	5x40	6x55	cb2_on	15.1135	0	No	No	Yes	No	5	6
61	5x43	6x55	cb2_on	16.3956	0	Yes	Yes	Yes	No	5	6
62	5x69	6x30	cb2_on	11.5752	0	No	No	Yes	No	5	7
63	5x69	6x29	cb2_on	23.5168	0	No	No	No	Yes	5	5
64	6x29	6x33	cb2_on	35.2841	0	No	Yes	No	No	5	7
65	3x54	6x33	cb2_on	36.6556	0	No	No	No	No	9	7
66	1x49	7x51	cb2_on	10.7666	8.68923	No	Yes	No	No	8	6
67	1x55	8x61	cb2_on	10.0965	2.357	No	No	No	No	5	0
68	5x68	6x29	cb2_on	11.1017	0	No	Yes	No	Yes	7	5
69	5x69	5x73	cb2_on	10.9364	0	No	No	Yes	No	5	4
70	2x57	2x61	cb2_on	14.4389	0.0492507	Yes	No	Yes	Yes	6	6
71	2x57	3x36	cb2_on	16.5788	0	Yes	No	Yes	No	6	6
72	2x46	7x53	cb2_on	25.5674	0	Yes	No	Yes	Yes	9	9
73	3x33	5x43	cb2_on	10.7353	0.872441	No	No	Yes	Yes	4	5
74	5x51	6x44	cb2_on	15.0911	0	Yes	No	No	No	7	9
75	3x40	5x51	cb2_on	13.0406	8.04193	No	No	Yes	No	8	7
76	2x64	NT.M26	Shared	19.2191	24.2313	Yes	Yes	No	No	3	6
77	E1.H98	NT.M26	Shared	17.794	18.8489	No	No	No	No	4	6
78	7x31	NT.I27	Shared	31.4912	10.1949	No	No	No	No	2	5
79	2x64	Lig	Shared	51.3939	42.5315	Yes	Yes	Yes	Yes	3	0
80	2x61	Lig	Shared	29.8472	16.5834	Yes	Yes	Yes	Yes	6	0
81	1x50	2x50	Shared	22.0068	30.7957	No	No	No	Yes	9	9
82	1x49	7x50	Shared	12.9736	14.3882	No	Yes	No	No	8	9
83	2x40	8x50	Shared	13.6615	47.1188	Yes	Yes	No	Yes	8	8
84	2x42	3x49	Shared	75.1742	60.6628	Yes	No	Yes	Yes	8	9
85	2x42	4x46	Shared	100	60.3884	Yes	No	Yes	No	8	8
86	3x34	4x57	Shared	59.0377	13.2062	Yes	No	No	No	5	7
87	3x33	4x57	Shared	59.2566	11.1658	No	No	No	No	4	7
88	3x33	Lig	Shared	49.2986	11.785	No	No	Yes	Yes	4	0
89	2x46	3x43	Shared	12.1649	93.3512	Yes	No	No	No	9	8
90	3x43	6x44	Shared	57.8225	92.9572	No	No	No	No	8	9
91	6x44	6x48	Shared	43.1782	90.2976	No	No	Yes	Yes	9	8
92	2x46	7x49	Shared	28.1406	99.3386	Yes	No	No	No	9	9
93	5x43	Lig	Shared	15.1671	72.1171	Yes	Yes	Yes	Yes	5	0
94	3x37	5x43	Shared	10.1858	64.9265	No	No	Yes	Yes	6	5
95	3x37	4x53	Shared	15.2073	68.4796	No	No	No	No	6	8
96	3x38	4x53	Shared	14.8231	67.8956	No	No	No	No	7	8
97	5x47	5x51	Shared	16.9719	12.0383	No	No	Yes	No	7	7
98	5x43	5x47	Shared	11.9684	14.0153	Yes	Yes	No	No	5	7
99	3x51	5x57	Shared	12.9423	26.525	No	No	No	No	8	6
100	3x51	3x55	Shared	10.2082	23.6333	No	No	No	No	8	6
101	E2.I186	Lig	Shared	15.9534	42.6441	Yes	Yes	Yes	Yes	5	0
102	5x37	E2.S180	Shared	10.1099	12.0242	No	No	No	No	4	4
103	7x31	E2.E181	Shared	28.3819	12.1931	No	No	No	No	2	4
104	6x47	7x45	Shared	15.0777	14.1349	No	No	No	No	8	9
105	E2.E181	E3.L273	Shared	19.0002	16.1472	No	No	No	Yes	4	1
106	1x50	7x50	Shared	13.1076	28.0377	No	No	No	No	9	9
107	2x45	4x46	Shared	37.4821	60.1562	No	No	Yes	No	9	8
108	3x38	4x50	Shared	14.7873	67.4734	No	No	Yes	No	7	9
109	3x29	Lig	cb2_off	4.55683	17.2166	No	Yes	Yes	Yes	4	0
110	E2.F183	Lig	cb2_off	9.27895	40.5826	Yes	No	Yes	Yes	6	0
111	5x39	Lig	cb2_off	0	26.4969	Yes	Yes	Yes	Yes	7	0
112	6x48	Lig	cb2_off	0	86.3576	Yes	Yes	Yes	Yes	8	0
113	2x64	3x25	cb2_off	3.97159	18.2298	Yes	Yes	Yes	Yes	3	9
114	3x25	E2.P184	cb2_off	3.52484	20.2561	Yes	Yes	No	No	9	5
115	E2.P184	NT.Y25	cb2_off	2.68049	17.3855	No	No	No	No	5	4
116	NT.P20	NT.Y25	cb2_off	0	14.4797	No	Yes	No	No	0	4
117	3x25	3x29	cb2_off	4.27091	19.7003	Yes	Yes	No	Yes	9	4
118	5x36	E2.I186	cb2_off	9.36383	18.2298	Yes	Yes	Yes	Yes	4	5
119	5x36	E2.C174	cb2_off	5.16887	11.1236	Yes	Yes	No	No	4	5
120	NT.P20	NT.P21	cb2_off	0	12.9529	No	Yes	No	No	0	0
121	E2.F183	E2.L182	cb2_off	3.12277	45.585	Yes	No	No	No	6	4
122	6x58	E2.L182	cb2_off	2.94853	31.4008	No	No	No	No	3	4
123	6x58	E3.L273	cb2_off	0	29.5434	No	No	No	Yes	3	1
124	1x32	NT.L28	cb2_off	0	15.1903	Yes	No	No	No	5	6
125	E1.H98	NT.L28	cb2_off	0	17.0267	No	No	No	No	4	6
126	1x46	2x54	cb2_off	1.854	11.5598	No	No	No	No	7	8
127	1x46	7x46	cb2_off	0	19.6581	No	No	No	No	7	9
128	2x50	7x46	cb2_off	1.83613	22.4161	No	Yes	No	No	9	9
129	2x46	2x50	cb2_off	0	60.9794	Yes	No	No	Yes	9	9
130	1x53	7x50	cb2_off	0	11.5598	No	No	No	No	9	9
131	8x50	8x53	cb2_off	0	13.6073	No	Yes	No	No	8	7
132	7x53	8x50	cb2_off	0	56.8634	Yes	Yes	No	Yes	9	8
133	6x40	7x53	cb2_off	1.44746	100	No	No	Yes	Yes	8	9
134	6x40	7x49	cb2_off	0	99.606	No	No	No	No	8	9
135	2x43	7x53	cb2_off	0	45.9931	No	No	Yes	Yes	8	9
136	2x40	2x43	cb2_off	1.76465	45.374	Yes	Yes	No	No	8	8
137	2x40	8x49	cb2_off	0.134024	33.0472	Yes	Yes	Yes	Yes	8	6
138	2x45	4x50	cb2_off	6.63867	62.8228	No	No	Yes	No	9	9
139	2x39	2x40	cb2_off	0	38.2396	No	No	Yes	Yes	8	8
140	3x49	3x50	cb2_off	0	61.9644	Yes	Yes	No	Yes	9	9
141	2x40	6x33	cb2_off	0	38.2045	Yes	Yes	No	No	8	7
142	2x48	4x50	cb2_off	0	19.5525	No	No	Yes	No	7	9
143	2x48	2x52	cb2_off	0	17.4418	No	No	No	No	7	7
144	2x51	2x52	cb2_off	0	11.004	Yes	Yes	No	No	7	7
145	3x25	E1.D101	cb2_off	0	12.2634	Yes	Yes	No	No	9	2
146	4x60	E2.I186	cb2_off	0	19.2007	No	No	Yes	Yes	5	5
147	4x60	E2.T173	cb2_off	0	31.2109	No	No	No	Yes	5	5
148	4x60	5x39	cb2_off	2.48392	15.9643	No	No	Yes	Yes	5	7
149	3x26	E2.T173	cb2_off	0	14.0083	No	No	No	Yes	5	5
150	3x50	5x61	cb2_off	0	65.025	No	Yes	No	No	9	9
151	5x58	5x61	cb2_off	0	62.3303	Yes	Yes	No	No	9	9
152	5x58	6x41	cb2_off	3.33721	46.1901	Yes	Yes	No	No	9	7
153	5x54	6x41	cb2_off	0	40.7725	No	No	No	No	8	7
154	3x44	5x54	cb2_off	2.9262	37.9512	Yes	No	No	No	6	8
155	3x50	6x30	cb2_off	0	22.0291	No	Yes	Yes	No	9	7
156	3x44	3x48	cb2_off	2.9262	35.1157	Yes	No	No	No	6	6
157	3x48	5x57	cb2_off	0	29.4027	No	No	No	No	6	6
158	6x30	I3.M237	cb2_off	1.67977	17.9202	Yes	No	No	No	7	4
159	5x68	I3.M237	cb2_off	0	14.9652	No	Yes	No	No	7	4
160	E2.I186	E2.S180	cb2_off	0	13.9802	Yes	Yes	No	No	5	4
161	7x34	E2.L182	cb2_off	2.5956	14.0083	Yes	No	No	No	4	4
162	5x37	6x59	cb2_off	7.59471	10.0542	No	No	No	No	4	3
163	3x55	5x64	cb2_off	4.86508	14.8737	No	No	No	No	6	6
164	6x29	8x49	cb2_off	0	22.2332	No	Yes	Yes	Yes	5	6
165	6x28	6x29	cb2_off	0	11.2854	No	Yes	No	Yes	4	5
166	6x36	7x53	cb2_off	0	12.777	No	No	Yes	Yes	8	9
167	6x44	7x45	cb2_off	0	16.9211	No	No	No	No	9	9
168	6x54	7x34	cb2_off	3.36401	12.1931	No	No	Yes	No	4	4
169	6x54	7x37	cb2_off	1.68424	10.1949	No	No	No	No	4	4
170	3x26	4x61	cb2_off	1.61276	10.5256	No	No	Yes	No	5	6
171	2x39	3x50	cb2_off	0	36.0937	No	No	No	Yes	8	9
172	3x50	6x33	cb2_off	0	36.2766	No	Yes	No	No	9	7

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
2x57	Lig	Shared	10.25	9.50167	1	1	1	0
2x60	Lig	Shared	3.16	3.765	0	0	1	0
2x61	Lig	Shared	3.42	3.83667	1	1	1	0
2x64	Lig	Shared	6.83	10.8033	0	1	1	0
3x29	Lig	Shared	5	6.57167	1	1	1	0
3x32	Lig	Shared	5.22	3.89167	0	1	1	0
3x33	Lig	Shared	5.17	10.9667	1	1	1	0
3x36	Lig	Shared	10.25	3.99833	1	1	1	0
E2.F183	Lig	Shared	21.35	26.8867	1	1	1	0
E2.I186	Lig	Shared	5	3.345	1	1	1	0
5x39	Lig	cb2_off	3.29	0	1	1	1	0
5x43	Lig	Shared	10.38	13.5167	1	1	1	0
6x48	Lig	cb2_off	7.98	0	1	1	1	0
6x51	Lig	cb2_off	3.13	0	1	0	1	0
6x55	Lig	cb2_off	5.95	0	0	0	1	0
7x38	Lig	Shared	3.16	7.33333	0	1	1	0
7x41	Lig	cb2_off	3.34	0	1	1	1	0
3x25	NT.M22	Shared	12.44	3.31833	0	1	2	2
E2.P184	NT.Y25	Shared	23.64	12.5167	0	0	1	2
2x64	NT.M26	Shared	9.95	6.01167	0	1	1	2
1x35	2x61	cb2_off	3.93	0	0	0	2	1
1x39	2x61	Shared	4.19	3.26	0	1	2	1
1x39	7x39	Shared	4.86	4.32	0	1	2	2
2x57	2x61	Shared	3.22	5.535	1	1	1	1
2x61	2x65	Shared	12.44	13.1983	1	1	1	2
2x64	2x65	Shared	6.79	7.35167	0	1	1	2
2x64	3x25	Shared	3.22	3.93	0	1	1	2
3x25	3x29	Shared	3.77	6.28	0	1	2	1
3x25	E2.P184	Shared	8.67	5.535	0	1	2	1
3x29	E2.F183	cb2_off	3.77	0	1	1	1	1
3x29	E2.I186	Shared	5.89	3.435	1	1	1	1
3x33	4x57	Shared	6.4	5.06333	1	1	1	2
3x33	5x43	Shared	4.85	4.64667	1	1	1	1
3x36	6x48	Shared	4.01	7.685	1	1	1	1
3x37	4x57	cb2_off	3.2	0	0	1	2	2
3x37	5x43	Shared	3.64	6.06333	0	1	2	1
3x40	5x51	Shared	3.93	5.67833	0	1	2	2
4x59	E2.W172	Shared	5.69	4.175	1	0	2	2
4x59	5x39	cb2_off	5.86	0	1	0	2	1
4x60	E2.I186	cb2_off	3.39	0	0	0	2	1
4x60	5x39	Shared	12.52	12.285	0	0	2	1
5x39	E2.W172	Shared	9.65	4.66167	1	1	1	2
E2.I186	E2.S180	cb2_off	3.1	0	1	1	1	2
E2.F183	E2.L182	Shared	3.65	4.265	1	1	1	2
7x34	E2.L182	Shared	14.61	9.135	0	1	1	2
5x36	E2.I186	Shared	3.39	3.95333	1	1	2	1
5x43	5x47	Shared	10.57	11.7433	1	1	1	2
6x44	6x48	Shared	4.56	3.23	0	1	2	1
6x44	7x45	cb2_off	5.49	0	0	1	2	2
6x48	6x52	cb2_off	3.42	0	1	1	1	2
6x48	7x41	Shared	3.92	7.40333	1	1	1	1
6x51	7x41	cb2_off	3.42	0	1	0	1	1
6x54	7x34	Shared	3.65	5.48167	0	0	2	1
5x44	6x55	Shared	2.83	5.18	0	0	2	1
5x47	5x51	Shared	2.51	4.605	0	1	2	2
5x42	E2.W172	cb2_off	2.47	0	0	0	2	2
NT.M22	NT.Y25	cb2_on	0	3.19167	0	1	2	2
2x64	NT.M22	cb2_on	0	3.11167	0	1	1	2
2x53	3x36	cb2_on	0	3.92833	0	0	2	1
2x57	3x32	cb2_on	0	4.58667	1	1	1	1
2x57	3x36	cb2_on	0	4.82333	1	1	1	1
2x57	7x38	cb2_on	0	4.62333	1	1	1	1
2x57	7x42	cb2_on	0	5.88667	1	1	1	2
2x60	3x28	cb2_on	0	5.865	0	0	1	2
2x61	7x39	cb2_on	0	3.52333	1	1	1	2
3x36	7x41	cb2_on	0	5.35333	1	1	1	1
3x40	6x48	cb2_on	0	3.065	0	1	2	1
5x36	E2.W172	cb2_on	0	8.33167	1	1	2	2
5x40	E2.S180	cb2_on	0	3	0	0	2	2
E2.F183	E2.I186	cb2_on	0	3.76833	1	1	1	1
6x55	E2.F183	cb2_on	0	4.56167	0	0	1	1
7x34	E2.F183	cb2_on	0	5.895	0	1	1	1
E2.P184	Lig	cb2_on	0	5.51167	0	0	1	0
5x39	E2.I186	cb2_on	0	3.42667	1	1	1	1
5x36	5x39	cb2_on	0	3.01167	1	1	2	1
5x39	5x43	cb2_on	0	4.98167	1	1	1	1
5x40	6x55	cb2_on	0	3.53333	0	0	2	1
5x43	6x55	cb2_on	0	3.87667	1	1	1	1
5x51	6x44	cb2_on	0	4.26167	0	1	2	2
5x51	6x48	cb2_on	0	8.01667	0	1	2	1
6x48	7x45	cb2_on	0	6.40333	1	1	1	2
7x34	Lig	cb2_on	0	6.41333	0	1	1	0
3x37	5x47	cb2_on	0	3.29333	0	1	2	2
6x51	7x34	cb2_on	0	2.83833	1	0	1	1
5x51	6x52	cb2_on	0	2.63833	0	1	2	2
5x39	5x42	cb2_on	0	1.06	1	1	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	cb2_off	5ZTY-CB₂-AM10257
	cb2_on	8GUR-CB₂-CP55,940-Gi1/β1/γ2 8GUS-CB₂-HU-308-Gi1/β1/γ2 8GUT-CB₂-LEI-102-Gi1/β1/γ2 6KPF-CB₂-PubChem 145915889-Gi1/β1/γ2 6PT0-CB₂-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB₂-Olorinab-Gi1/β1/γ2

Network Difference
Value	cb2_on	cb2_off
I_min	2.97667	3.07
Number of Linked Nodes	290	259
Number of Specific Nodes	37 (12.76%)	6 (2.32%)
Number of Shared Nodes	253 (87.24%)	253 (97.68%)
Number of Links	328	282
Number of Specific Links	157 (47.87%)	111 (39.36%)
Number of Shared Links	171 (52.13%)	171 (60.64%)
Number of Hubs	42	30
Number of Specific Hubs	24 (57.14%)	12 (40.00%)
Number of Shared Hubs	18 (42.86%)	18 (60.00%)
Average % Shared Neighbours (Jaccard)	41.46
Average % Shared Neighbours (Otsuka)	50.78
Average % Shared Neighbours (Overlap Coefficient)	61.06
Average % Shared Cliques (k3-6)	53.05
Graphlets Similarity	0.583736

Paths Difference
Value	cb2_on	cb2_off
Number Of Nodes in MetaPath	97	93
Specific Nodes in MetaPath	41 (42.27%)	37 (39.78%)
Shared Nodes in MetaPath	253 (87.24%)	253 (87.24%)
Number Of Links MetaPath	108	97
Specific Links in MetaPath	75 (69.44%)	64 (65.98%)
Shared Links in MetaPath	171 (52.13%)	171 (52.13%)
Number of Shortest Paths	66499	45292
Length Of Smallest Path	3	3
Average Path Length	13.4414	13.2671
Length of Longest Path	32	34
Minimum Path Strength	0.29	1.14
Average Path Strength	5.01772	5.49203
Maximum Path Strength	17.3822	16.465
Minimum Path Correlation	0.7	0.7
Average Path Correlation	0.92603	0.925415
Maximum Path Correlation	0.99	0.99
Minimum % Of Corr. Nodes	3.57143	4.34783
Average % Of Corr. Nodes	48.8459	50.8221
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	42.0336	34.2653
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

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