Orange: nodes, hubs and links specific of cb2_on_gp network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of cb2_off network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.


Index Hub Owner cb2_on_gp Avg Int. Strength cb2_off Avg Int. Strength cb2_on_gp Num Of Links cb2_off Num Of Links ConSurf
1G.HN.11 cb2_on_gp2.409670502
2G.S1.02 cb2_on_gp5.175330505
3G.S1.05 cb2_on_gp6.508750409
4G.H1.01 cb2_on_gp5.405830409
5G.H1.08 cb2_on_gp5.858330408
6G.S2.06 cb2_on_gp7.755420409
7G.S2.08 cb2_on_gp7.219170405
8G.S3.01 cb2_on_gp6.119170404
9G.S3.03 cb2_on_gp8.0810507
10G.S3.04 cb2_on_gp7.7450406
11G.S3.05 cb2_on_gp4.200830407
12G.S3.06 cb2_on_gp8.1810505
13G.H2.03 cb2_on_gp6.431250409
14G.H2.04 cb2_on_gp4.018750409
15G.H2.06 cb2_on_gp5.900240709
16G.H2.07 cb2_on_gp5.877380709
17G.h2s4.01 cb2_on_gp7.4050509
18G.S4.02 cb2_on_gp4.5020508
19G.S4.04 cb2_on_gp6.182920409
20G.s4h3.04 cb2_on_gp6.720330508
21G.s4h3.05 cb2_on_gp6.557920409
22G.H3.01 cb2_on_gp4.901250409
23G.H3.03 cb2_on_gp3.172670504
24G.H3.06 cb2_on_gp4.660420406
25G.H3.09 cb2_on_gp6.737140709
26G.H3.13 cb2_on_gp4.598750405
27G.H3.17 cb2_on_gp8.223050605
28G.H3.18 cb2_on_gp5.1570509
29G.S5.03 cb2_on_gp3.622080408
30G.S5.04 cb2_on_gp4.485670509
31G.S5.07 cb2_on_gp4.482080409
32G.HG.04 cb2_on_gp6.568670509
33G.HG.15 cb2_on_gp4.083330507
34G.hgh4.02 cb2_on_gp7.108670507
35G.hgh4.05 cb2_on_gp6.193330407
36G.H4.03 cb2_on_gp5.288670504
37G.H4.05 cb2_on_gp2.691250404
38G.H4.10 cb2_on_gp8.652920406
39G.H4.15 cb2_on_gp6.3750408
40G.h4s6.02 cb2_on_gp5.710420408
41G.S6.02 cb2_on_gp9.147080407
42G.s6h5.01 cb2_on_gp6.736670409
43G.s6h5.02 cb2_on_gp3.00250407
44G.s6h5.05 cb2_on_gp3.023330409
45G.H5.03 cb2_on_gp7.289170408
46G.H5.06 cb2_on_gp8.4650403
47G.H5.08 cb2_on_gp6.534170408
48G.H5.13 cb2_on_gp8.88250408
49G.H5.25 cb2_on_gp5.505670507
50b.1x1 cb2_on_gp2.0350404
51b.1x7 cb2_on_gp2.9150408
52b.1x16 cb2_on_gp2.351250404
53b.1x19 cb2_on_gp4.945830406
54b.h2x1 cb2_on_gp4.680405
55b.lhb1x3 cb2_on_gp2.135420402
56b.b1x3 cb2_on_gp3.538750407
57b.b1x4 cb2_on_gp4.453750407
58b.l1x3 cb2_on_gp7.503330709
59b.b2x1 cb2_on_gp10.22870508
60b.b2x5 cb2_on_gp7.120670507
61b.b3x3 cb2_on_gp4.939170408
62b.l3x2 cb2_on_gp5.099330509
63b.b4x3 cb2_on_gp5.662080407
64b.b4x4 cb2_on_gp9.276250408
65b.b4x5 cb2_on_gp4.636670407
66b.b4x6 cb2_on_gp9.307860709
67b.b5x2 cb2_on_gp5.239580407
68b.b5x3 cb2_on_gp6.644050709
69b.b5x5 cb2_on_gp5.981670405
70b.b5x7 cb2_on_gp6.71250407
71b.l5x1 cb2_on_gp4.966670408
72b.l5x2 cb2_on_gp4.391250406
73b.l5x5 cb2_on_gp9.148060609
74b.b6x5 cb2_on_gp4.22310706
75b.b7x1 cb2_on_gp6.991670404
76b.l7x2 cb2_on_gp4.705830409
77b.b8x3 cb2_on_gp5.028330406
78b.b8x4 cb2_on_gp6.191670506
79b.l8x5 cb2_on_gp2.260330503
80b.b9x3 cb2_on_gp5.494170406
81b.l9x3 cb2_on_gp8.675330509
82b.l9x6 cb2_on_gp5.880710708
83b.b10x5 cb2_on_gp4.553890609
84b.b11x2 cb2_on_gp4.48750407
85b.l11x2 cb2_on_gp7.928750409
86b.b12x3 cb2_on_gp3.976670408
87b.b12x6 cb2_on_gp8.482140708
88b.b12x7 cb2_on_gp5.349580409
89b.b13x7 cb2_on_gp7.951670507
90b.l13x3 cb2_on_gp7.613330609
91b.l13x6 cb2_on_gp7.437920409
92b.b14x3 cb2_on_gp5.70405
93b.b15x1 cb2_on_gp6.528810709
94b.b15x2 cb2_on_gp7.284580406
95b.l15x1 cb2_on_gp4.729670507
96b.b16x4 cb2_on_gp10.7350406
97b.b16x5 cb2_on_gp5.375830405
98b.b16x6 cb2_on_gp8.998330608
99b.b17x5 cb2_on_gp7.398750407
100b.b17x7 cb2_on_gp8.7750408
101b.l17x3 cb2_on_gp8.046190709
102b.l17x6 cb2_on_gp6.590509
103b.b18x3 cb2_on_gp4.768750408
104b.l18x1 cb2_on_gp6.9250606
105b.l18x2 cb2_on_gp5.717080407
106b.b19x2 cb2_on_gp8.224330506
107b.b19x4 cb2_on_gp6.835830408
108b.l19x2 cb2_on_gp6.586330509
109b.b20x4 cb2_on_gp11.42530508
110b.b20x6 cb2_on_gp6.754520706
111b.b21x1 cb2_on_gp9.887080407
112b.b21x2 cb2_on_gp3.5950406
113b.b21x5 cb2_on_gp5.787920404
114b.b21x7 cb2_on_gp7.519330505
115b.l21x2 cb2_on_gp4.907920404
116b.b22x5 cb2_on_gp5.679440607
117b.l22x5 cb2_on_gp6.818330609
118b.b23x1 cb2_on_gp4.009170405
119b.b23x6 cb2_on_gp7.041190707
120b.b24x6 cb2_on_gp6.84250408
121b.b25x3 cb2_on_gp6.406670405
122b.l25x3 cb2_on_gp9.6670509
123b.l25x6 cb2_on_gp12.75830408
124b.l27x1 cb2_on_gp11.640709
125b.l27x2 cb2_on_gp7.268330409
126b.b28x3 cb2_on_gp4.7390507
127b.b28x4 cb2_on_gp9.173750406
128b.b28x6 cb2_on_gp8.703670509
129b.b28x7 cb2_on_gp5.63250409
130g.h2x11 cb2_on_gp10.25630406
131g.ctx3 cb2_on_gp7.633750409
132g.ctx6 cb2_on_gp3.765330506
133g.ctx14 cb2_on_gp5.815420409
134g.ctx15 cb2_on_gp7.987920409
135g.ctx16 cb2_on_gp5.168150908
1361x32 cb2_on_gp2.716677.39435
1371x42 cb2_on_gp3.130335.54516
1382x42 cb2_on_gp5.235835.32333438
1392x46 cb2_on_gp3.969674.10667539
1402x57 cb2_on_gp5.826116.735626
1412x65 cb2_on_gp6.467926.89667434
1423x36 cb2_on_gp5.157677.13526
1433x44 cb2_on_gp2.891254.28426
1443x56 cb2_on_gp6.9954210.41425
1454x46 cb2_on_gp4.568756.33428
1464x50 cb2_on_gp4.810425.41333439
1474x58 cb2_on_gp4.707925.14333434
1484x61 cb2_on_gp2.829171.85333436
149E2.F183 cb2_on_gp9.075339.59536
1505x50 cb2_on_gp3.360428.46427
1515x51 cb2_on_gp5.043.77537
1525x73 cb2_on_gp0.42250404
153I3.H226 cb2_on_gp4.862080404
1546x55 cb2_on_gp4.287924.39426
1557x34 cb2_on_gp5.952679.13524
156H.HA.19 cb2_on_gp0.6791670400
157H.HC.03 cb2_on_gp0.3320500
158H.HC.07 cb2_on_gp0.5466670400
159H.HD.07 cb2_on_gp0.7641670400
160H.hdhe.01 cb2_on_gp0.6097220600
161H.HE.05 cb2_on_gp0.5830500
162H.HE.06 cb2_on_gp0.7154170400
163H.HF.06 cb2_on_gp0.991250400
1642x40 Shared6.207626.785788
1652x51 Shared4.038332.94447
1662x61 Shared5.870675.44556
1672x64 Shared7.024176.6975443
1682x66 Shared2.785.6375444
1693x25 Shared4.340336.098559
1703x49 Shared6.80256.9475449
1713x50 Shared7.997924.58167469
172I2x53 Shared7.4677.58547
173E2.W172 Shared4.215337.172555
174E2.I186 Shared3.585674.154555
1755x39 Shared5.2837.83547
1765x43 Shared7.471397.36645
1775x58 Shared6.255565.686659
1786x48 Shared6.547674.778558
1797x53 Shared5.890834.595649
1808x49 Shared4.6458.215446
181Lig Shared8.310126.6414170
182NT.P20 cb2_off03.635040
1831x49 cb2_off3.700835.01248
1842x50 cb2_off7.792225.985349
1853x29 cb2_off5.428894.6075344
186E2.T173 cb2_off3.382.715145
187E2.R177 cb2_off4.0956.48343
1885x36 cb2_off5.4554.145344
1895x68 cb2_off6.573895.88347
1906x28 cb2_off2.136674.1625244
1916x29 cb2_off3.1554.885245
192E3.L273 cb2_off4.010563.4625341
1938x50 cb2_off4.358335.215348
   
Orange: nodes, hubs and links specific of cb2_on_gp network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of cb2_off network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Owner cb2_on_gp Recurrence cb2_off Recurrence cb2_on_gp Hub1? cb2_off Hub1? cb2_on_gp Hub2? cb2_off Hub2? ConSurf1 ConSurf2
1b.l26x5 g.ctx4 cb2_on_gp16.00780NoNoNoNo57
2g.ctx3 g.ctx4 cb2_on_gp16.64690YesNoNoNo97
3g.ctx3 g.ctx6 cb2_on_gp22.31930YesNoYesNo96
4b.l22x5 g.ctx6 cb2_on_gp29.73020YesNoYesNo96
5b.l22x5 b.l24x2 cb2_on_gp31.37470YesNoNoNo96
6b.h2x5 b.l24x2 cb2_on_gp31.67170NoNoNoNo56
7b.h2x1 b.h2x5 cb2_on_gp31.80610YesNoNoNo55
8b.b21x5 b.h2x1 cb2_on_gp32.06550YesNoYesNo45
9b.b21x5 b.b21x7 cb2_on_gp33.27110YesNoYesNo45
10b.b21x7 b.b24x6 cb2_on_gp39.67280YesNoYesNo58
11b.b23x6 b.b24x6 cb2_on_gp39.77530YesNoYesNo78
12b.b23x6 b.l21x7 cb2_on_gp41.66740YesNoNoNo75
13b.l21x7 b.l23x1 cb2_on_gp42.5690NoNoNoNo56
14b.l23x1 b.l25x6 cb2_on_gp42.90260NoNoYesNo68
15G.H3.17 b.l25x6 cb2_on_gp42.59080YesNoYesNo58
16G.H3.15 G.H3.17 cb2_on_gp44.75810NoNoYesNo85
17G.H2.08 G.H3.15 cb2_on_gp22.68760NoNoNoNo88
18G.H2.04 G.H2.08 cb2_on_gp22.94690YesNoNoNo98
19G.H2.04 G.H3.08 cb2_on_gp83.55440YesNoNoNo99
20G.H3.08 G.S4.04 cb2_on_gp83.58140NoNoYesNo99
21G.S4.04 G.S5.04 cb2_on_gp78.50770YesNoYesNo99
22G.S5.04 G.S5.06 cb2_on_gp1000YesNoNoNo98
23G.S5.06 G.s4h3.01 cb2_on_gp51.53680NoNoNoNo87
24G.HG.04 G.s4h3.01 cb2_on_gp50.09620YesNoNoNo97
25G.H4.03 G.HG.04 cb2_on_gp50.52940YesNoYesNo49
26G.H4.03 G.HG.01 cb2_on_gp98.24670YesNoNoNo45
27G.HG.01 G.s6h5.02 cb2_on_gp98.09270NoNoYesNo57
28G.s6h5.02 G.s6h5.05 cb2_on_gp97.47570YesNoYesNo79
29G.H5.03 G.s6h5.05 cb2_on_gp96.65510YesNoYesNo89
30G.H5.03 G.S6.04 cb2_on_gp87.36930YesNoNoNo89
31G.H5.06 G.S6.04 cb2_on_gp87.34460YesNoNoNo39
32G.H5.06 I3.H226 cb2_on_gp79.88040YesNoYesNo34
33G.H5.05 I3.H226 cb2_on_gp78.91260NoNoYesNo54
34G.H5.05 G.S2.08 cb2_on_gp78.80430NoNoYesNo55
35G.H5.08 G.S2.08 cb2_on_gp75.20640YesNoYesNo85
36G.H5.08 G.S3.01 cb2_on_gp74.91730YesNoYesNo84
37G.S3.01 I2x51 cb2_on_gp73.62320YesNoNoNo47
38G.H5.15 I2x51 cb2_on_gp74.15830NoNoNoNo77
39G.H5.15 G.H5.19 cb2_on_gp73.98840NoNoNoNo78
40G.H5.19 I2x53 cb2_on_gp73.81830NoNoYesYes87
413x52 I2x53 cb2_on_gp12.1580NoNoYesYes57
423x52 3x56 cb2_on_gp11.9490NoNoYesNo55
43G.H3.15 G.H3.18 cb2_on_gp22.24990NoNoYesNo89
44G.H3.18 G.S4.02 cb2_on_gp22.33570YesNoYesNo98
45G.S4.02 G.S5.02 cb2_on_gp24.55870YesNoNoNo86
46G.H3.09 G.S5.02 cb2_on_gp24.28730YesNoNoNo96
47G.H3.09 G.S5.04 cb2_on_gp22.95560YesNoYesNo99
48G.S5.06 G.S6.05 cb2_on_gp48.46080NoNoNoNo84
49G.H4.07 G.S6.05 cb2_on_gp48.6340NoNoNoNo54
50G.H4.03 G.H4.07 cb2_on_gp48.57790YesNoNoNo45
51G.H2.04 G.H2.07 cb2_on_gp65.29210YesNoYesNo99
52G.H2.06 b.l9x6 cb2_on_gp64.3560YesNoYesNo98
53G.H2.06 b.l17x6 cb2_on_gp63.78510YesNoYesNo99
54b.l17x5 b.l17x6 cb2_on_gp64.13420NoNoYesNo69
55b.l17x5 b.l19x2 cb2_on_gp64.20060NoNoYesNo69
56b.l17x3 b.l19x2 cb2_on_gp63.54810YesNoYesNo99
57b.b20x6 b.l17x3 cb2_on_gp61.30920YesNoYesNo69
58b.b17x7 b.b20x6 cb2_on_gp59.89270YesNoYesNo86
59b.b17x7 b.b21x1 cb2_on_gp59.58810YesNoYesNo87
60b.1x19 b.b21x1 cb2_on_gp60.43070YesNoYesNo67
61b.1x15 b.1x19 cb2_on_gp58.97980NoNoYesNo76
62b.1x15 g.h1x14 cb2_on_gp58.83810NoNoNoNo79
63b.b17x6 g.h1x14 cb2_on_gp29.92110NoNoNoNo79
64b.b16x4 b.b17x6 cb2_on_gp29.85450YesNoNoNo67
65b.b16x4 b.b16x6 cb2_on_gp28.64440YesNoYesNo68
66b.b15x1 b.b16x6 cb2_on_gp40.20890YesNoYesNo98
67b.b14x5 b.b15x1 cb2_on_gp20.86730NoNoYesNo59
68b.b10x4 b.b14x5 cb2_on_gp22.27230NoNoNoNo65
69b.b10x4 b.b2x4 cb2_on_gp23.85440NoNoNoNo66
70b.b2x4 b.b6x5 cb2_on_gp23.68930NoNoYesNo66
71g.h1x10 g.h1x14 cb2_on_gp28.88270NoNoNoNo99
72b.b17x3 g.h1x10 cb2_on_gp29.55870NoNoNoNo59
73b.b16x6 b.b17x3 cb2_on_gp29.48610YesNoNoNo85
74G.H2.07 b.l9x6 cb2_on_gp65.16470YesNoYesNo98
75G.H5.10 G.S5.03 cb2_on_gp14.39320NoNoYesNo68
76G.H5.10 G.S6.02 cb2_on_gp14.04210NoNoYesNo67
773x55 3x56 cb2_on_gp10.52965.98748NoNoYesNo65
782x46 3x42 cb2_on_gp11.76940YesNoNoNo98
792x45 3x42 cb2_on_gp11.95538.91437NoNoNoNo98
803x49 I2x53 cb2_on_gp53.76646.81067YesYesYesYes97
81b.lhb1x11 g.ctx5 cb2_on_gp11.12910NoNoNoNo49
82b.l22x1 g.ctx5 cb2_on_gp11.41330NoNoNoNo99
83b.b3x2 b.b4x6 cb2_on_gp11.14450NoNoYesNo59
84b.b2x5 b.b3x2 cb2_on_gp11.19980YesNoNoNo75
85b.b10x2 b.b6x2 cb2_on_gp21.60890NoNoNoNo68
86b.b10x3 b.b6x2 cb2_on_gp21.39240NoNoNoNo88
87b.b10x3 b.b11x2 cb2_on_gp14.40130NoNoYesNo87
88b.l26x1 b.l26x3 cb2_on_gp10.03850NoNoNoNo77
89b.l26x3 b.l26x5 cb2_on_gp10.3340NoNoNoNo75
90b.b3x3 b.b6x5 cb2_on_gp15.48820YesNoYesNo86
91b.b7x1 b.b8x3 cb2_on_gp12.34320YesNoYesNo46
92b.b10x2 b.b14x3 cb2_on_gp19.27250NoNoYesNo65
93b.b12x5 b.b13x4 cb2_on_gp19.02680NoNoNoNo64
94b.b12x7 b.b13x4 cb2_on_gp18.80810YesNoNoNo94
95b.b13x5 b.b13x7 cb2_on_gp17.59590NoNoYesNo47
96b.b12x7 b.l12x3 cb2_on_gp18.15120YesNoNoNo95
974x46 4x50 cb2_on_gp37.65420YesNoYesNo89
98b.b13x2 b.l12x3 cb2_on_gp17.9320NoNoNoNo45
99H.hdhe.01 b.b13x2 cb2_on_gp17.70740YesNoNoNo04
100H.hdhe.01 H.hdhe.03 cb2_on_gp16.23180YesNoNoNo00
101H.HD.07 H.hdhe.03 cb2_on_gp15.81020YesNoNoNo00
102b.b14x3 b.b15x1 cb2_on_gp19.30780YesNoYesNo59
103b.b3x3 b.b4x3 cb2_on_gp14.44730YesNoYesNo87
104b.b13x7 b.b16x6 cb2_on_gp17.59140YesNoYesNo78
105b.b12x5 b.b13x5 cb2_on_gp17.38430NoNoNoNo64
1062x45 4x46 Shared12.127960.1562NoNoYesNo98
1072x42 4x46 Shared50.148260.3884YesNoYesNo88
1082x42 3x49 Shared53.060660.6628YesNoYesYes89
1095x43 Lig Shared25.113372.1171YesYesYesYes50
1103x37 5x43 Shared33.574364.9265NoNoYesYes65
1113x37 4x53 Shared36.922168.4796NoNoNoNo68
1123x38 4x53 Shared37.111767.8956NoNoNoNo78
1133x38 4x50 Shared37.302967.4734NoNoYesNo79
1142x64 Lig cb2_off8.8621842.5315YesYesYesYes30
1153x29 Lig cb2_off1.4397617.2166NoYesYesYes40
1163x33 Lig cb2_off0.1610911.785NoNoYesYes40
117E2.F183 Lig cb2_off0.74201540.5826YesNoYesYes60
118E2.I186 Lig cb2_off1.0459242.6441YesYesYesYes50
1195x39 Lig cb2_off026.4969YesYesYesYes70
1206x48 Lig cb2_off086.3576YesYesYesYes80
1212x64 3x25 cb2_off1.2493818.2298YesYesYesYes39
1223x25 E2.P184 cb2_off1.233720.2561YesYesNoNo95
123E2.P184 NT.Y25 cb2_off0.43811317.3855NoNoNoNo54
124NT.P20 NT.Y25 cb2_off014.4797NoYesNoNo04
1253x25 3x29 cb2_off1.241619.7003YesYesNoYes94
1265x36 E2.I186 cb2_off1.3345818.2298NoYesYesYes45
1275x36 E2.C174 cb2_off1.232511.1236NoYesNoNo45
128NT.P20 NT.P21 cb2_off012.9529NoYesNoNo00
1292x64 NT.M26 cb2_off2.7962824.2313YesYesNoNo36
130E1.H98 NT.M26 cb2_off2.5819418.8489NoNoNoNo46
131E2.F183 E2.L182 cb2_off0.83353445.585YesNoNoNo64
1326x58 E2.L182 cb2_off0.63082731.4008NoNoNoNo34
1336x58 E3.L273 cb2_off029.5434NoNoNoYes31
134E2.E181 E3.L273 cb2_off2.5967416.1472NoNoNoYes41
1357x31 E2.E181 cb2_off3.8934312.1931NoNoNoNo24
1367x31 NT.I27 cb2_off4.3254110.1949NoNoNoNo25
1371x32 NT.L28 cb2_off015.1903YesNoNoNo56
138E1.H98 NT.L28 cb2_off017.0267NoNoNoNo46
1391x46 2x54 cb2_off0.21573611.5598NoNoNoNo78
1401x46 7x46 cb2_off019.6581NoNoNoNo79
1412x50 7x46 cb2_off0.2197222.4161NoYesNoNo99
1422x46 2x50 cb2_off060.9794YesNoNoYes99
1432x46 3x43 cb2_off0.21693893.3512YesNoNoNo98
1443x43 6x44 cb2_off092.9572NoNoNoNo89
1456x44 6x48 cb2_off0.21396590.2976NoNoYesYes98
1461x49 7x50 cb2_off1.7546614.3882NoYesNoNo89
1471x50 7x50 cb2_off1.9734428.0377NoNoNoNo99
1481x50 2x50 cb2_off3.2834130.7957NoNoNoYes99
1491x53 7x50 cb2_off011.5598NoNoNoNo99
1508x50 8x53 cb2_off013.6073NoYesNoNo87
1517x53 8x50 cb2_off056.8634YesYesNoYes98
1526x40 7x53 cb2_off0.218266100NoNoYesYes89
1536x40 7x49 cb2_off099.606NoNoNoNo89
1542x46 7x49 cb2_off7.4984599.3386YesNoNoNo99
1552x43 7x53 cb2_off045.9931NoNoYesYes89
1562x40 2x43 cb2_off0.2173845.374YesYesNoNo88
1572x40 8x50 cb2_off1.7354447.1188YesYesNoYes88
1582x40 8x49 cb2_off0.0022136533.0472YesYesYesYes86
1592x45 4x50 cb2_off0.032066362.8228NoNoYesNo99
1602x39 2x40 cb2_off038.2396NoNoYesYes88
1613x49 3x50 cb2_off061.9644YesYesYesYes99
1622x40 6x33 cb2_off038.2045YesYesNoNo87
1632x48 4x50 cb2_off019.5525NoNoYesNo79
1642x48 2x52 cb2_off017.4418NoNoNoNo77
1652x51 2x52 cb2_off011.004YesYesNoNo77
1663x25 E1.D101 cb2_off012.2634YesYesNoNo92
1674x60 E2.I186 cb2_off019.2007NoNoYesYes55
1684x60 E2.T173 cb2_off031.2109NoNoNoYes55
1694x60 5x39 cb2_off0.22870215.9643NoNoYesYes57
1703x26 E2.T173 cb2_off014.0083NoNoNoYes55
1713x33 4x57 cb2_off2.5751111.1658NoNoNoNo47
1723x34 4x57 cb2_off2.361213.2062NoNoNoNo57
1735x43 5x47 cb2_off0.23059914.0153YesYesNoNo57
1745x47 5x51 cb2_off3.1871512.0383NoNoYesNo77
1753x50 5x61 cb2_off065.025YesYesNoNo99
1765x58 5x61 cb2_off062.3303YesYesNoNo99
1775x58 6x41 cb2_off0.44190846.1901YesYesNoNo97
1785x54 6x41 cb2_off040.7725NoNoNoNo87
1793x44 5x54 cb2_off0.22440137.9512YesNoNoNo68
1803x50 6x30 cb2_off022.0291YesYesNoNo97
1813x44 3x48 cb2_off0.22440135.1157YesNoNoNo66
1823x48 5x57 cb2_off029.4027NoNoNoNo66
1833x51 5x57 cb2_off9.2555826.525NoNoNoNo86
1843x51 3x55 cb2_off9.7900823.6333NoNoNoNo86
1856x30 I3.M237 cb2_off0.78413817.9202NoNoNoNo74
1865x68 I3.M237 cb2_off014.9652NoYesNoNo74
187E2.I186 E2.S180 cb2_off013.9802YesYesNoNo54
1885x37 E2.S180 cb2_off0.92106812.0242NoNoNoNo44
1897x34 E2.L182 cb2_off0.42799314.0083YesNoNoNo44
1905x37 6x59 cb2_off0.69097510.0542NoNoNoNo43
1913x55 5x64 cb2_off0.65568314.8737NoNoNoNo66
1926x29 8x49 cb2_off022.2332NoYesYesYes56
1936x28 6x29 cb2_off011.2854NoYesNoYes45
1946x36 7x53 cb2_off012.777NoNoYesYes89
1956x44 7x45 cb2_off016.9211NoNoNoNo99
1966x47 7x45 cb2_off1.7546614.1349NoNoNoNo89
1976x54 7x34 cb2_off0.43646812.1931NoNoYesNo44
1986x54 7x37 cb2_off0.21826610.1949NoNoNoNo44
1993x26 4x61 cb2_off0.2152310.5256NoNoYesNo56
2002x61 Lig cb2_off5.2982116.5834YesYesYesYes60
2012x39 3x50 cb2_off036.0937NoNoYesYes89
2023x50 6x33 cb2_off036.2766YesYesNoNo97

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Midway



Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Node1Node2OwnerNet1LinkStrengthNet2LinkStrengthComm1Comm2Node1ShellNode2Shell
2x57LigShared10.259.501671310
2x60LigShared3.163.7650010
2x61LigShared3.423.836671310
2x64LigShared6.8310.80330010
3x29LigShared56.571671310
3x32LigShared5.223.891670310
3x33LigShared5.1710.96671310
3x36LigShared10.253.998331310
E2.F183LigShared21.3526.88671310
E2.I186LigShared53.3451310
5x39Ligcb2_off3.2901010
5x43LigShared10.3813.51671310
6x48Ligcb2_off7.9801310
6x51Ligcb2_off3.1301010
6x55Ligcb2_off5.9500010
7x38LigShared3.167.333330310
7x41Ligcb2_off3.3401310
E2.P184NT.Y25Shared23.6412.51670012
2x64NT.M26Shared9.956.011670012
1x352x61cb2_off3.9300021
1x392x61Shared4.193.260321
1x397x39Shared4.864.320322
2x572x61Shared3.225.5351311
2x612x65Shared12.4413.19831312
2x642x65Shared6.797.351670012
2x643x25Shared3.223.930012
3x253x29Shared3.776.280021
3x25E2.P184Shared8.675.5350021
3x29E2.F183cb2_off3.7701311
3x29E2.I186Shared5.893.4351311
3x334x57Shared6.45.063331312
3x335x43Shared4.854.646671311
3x366x48Shared4.017.6851311
3x374x57cb2_off3.200322
3x375x43Shared3.646.063330321
4x59E2.W172Shared5.694.1751022
4x595x39cb2_off5.8601021
4x60E2.I186cb2_off3.3900021
4x605x39Shared12.5212.2850021
5x39E2.W172Shared9.654.661671012
E2.I186E2.S180cb2_off3.101312
E2.F183E2.L182Shared3.654.2651312
7x34E2.L182Shared14.619.1350312
5x36E2.I186Shared3.393.953331021
5x435x47Shared10.5711.74331312
6x446x48Shared4.563.230321
6x447x45cb2_off5.4900322
6x486x52cb2_off3.4201312
6x487x41Shared3.927.403331311
6x517x41cb2_off3.4201011
6x547x34Shared3.655.481670021
5x446x55Shared2.835.180021
5x475x51Shared2.514.6050322
5x42E2.W172cb2_off2.4700022
2x533x36cb2_on_gp03.928330021
2x573x32cb2_on_gp04.586671311
2x573x36cb2_on_gp04.823331311
2x577x38cb2_on_gp04.623331311
2x577x42cb2_on_gp05.886671312
2x603x28cb2_on_gp05.8650012
2x617x39cb2_on_gp03.523331312
3x367x41cb2_on_gp05.353331311
5x36E2.W172cb2_on_gp08.331671022
E2.F183E2.I186cb2_on_gp03.768331311
6x55E2.F183cb2_on_gp04.561670011
7x34E2.F183cb2_on_gp05.8950311
E2.P184Ligcb2_on_gp05.511670010
5x39E2.I186cb2_on_gp03.426671011
5x395x43cb2_on_gp04.981671011
5x406x55cb2_on_gp03.533330021
5x436x55cb2_on_gp03.876671311
5x516x44cb2_on_gp04.261670322
5x516x48cb2_on_gp08.016670321
6x487x45cb2_on_gp06.403331312
7x34Ligcb2_on_gp06.413330310
3x375x47cb2_on_gp03.293330322
5x40E2.S180cb2_on_gp030022
6x517x34cb2_on_gp02.838331011
5x516x52cb2_on_gp02.638330322
5x395x42cb2_on_gp01.061012

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
Id Description
cb2_on_gp 8GUR-CB2-CP55,940-Gi1/β1/γ2
8GUS-CB2-HU-308-Gi1/β1/γ2
8GUT-CB2-LEI-102-Gi1/β1/γ2
6KPF-CB2-PubChem 145915889-Gi1/β1/γ2
6PT0-CB2-WIN 55212-2-Gi1/β1/γ2
8GUQ-CB2-Olorinab-Gi1/β1/γ2
cb2_off 5ZTY-CB2-AM10257
Network Difference
Value cb2_on_gp cb2_off
Imin 3.2 3.07
Number of Linked Nodes 1021 259
Number of Specific Nodes 766 (75.02%) 4  (1.54%)
Number of Shared Nodes 255 (24.98%) 255  (98.46%)
Number of Links 1209 282
Number of Specific Links 1040 (86.02%) 113  (40.07%)
Number of Shared Links 169 (13.98%) 169  (59.93%)
Number of Hubs 181 30
Number of Specific Hubs 163 (90.06%) 12  (40.00%)
Number of Shared Hubs 18 (9.94%) 18  (60.00%)
Average % Shared Neighbours (Jaccard) 11.86
Average % Shared Neighbours (Otsuka) 14.56
Average % Shared Neighbours (Overlap Coefficient) 17.41
Average % Shared Cliques (k3-6) 50.92
Graphlets Similarity 0.643095
Paths Difference
Value cb2_on_gp cb2_off
Number Of Nodes in MetaPath 115 93
Specific Nodes in MetaPath 103 (89.57%) 81  (87.10%)
Shared Nodes in MetaPath 255 (24.98%) 255  (24.98%)
Number Of Links MetaPath 113 97
Specific Links in MetaPath 105 (92.92%) 89  (91.75%)
Shared Links in MetaPath 169 (13.98%) 169  (13.98%)
Number of Shortest Paths 2252830 45292
Length Of Smallest Path 3 3
Average Path Length 42.0407 13.2671
Length of Longest Path 81 34
Minimum Path Strength 0.29 1.14
Average Path Strength 5.98691 5.49203
Maximum Path Strength 22.4358 16.465
Minimum Path Correlation 0.701667 0.7
Average Path Correlation 0.980448 0.925415
Maximum Path Correlation 1 0.99
Minimum % Of Corr. Nodes 1.42857 4.34783
Average % Of Corr. Nodes 31.744 50.8221
Maximum % Of Corr. Nodes 100 100
Minimum Path Hubs % 0 0
Average Path Hubs % 54.7316 34.2653
Maximum Path Hubs % 100 100

Details about the values in these tables can be found in the corresponding documentation page .

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download cb2_off_on_gp.zip<



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