psnGPCR

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Orange: nodes, hubs and links specific of ccka_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of ccka_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	ccka_off Int. Strength	ccka_on Int. Strength	ccka_off Hub1?	ccka_on Hub1?	ccka_off Hub2?	ccka_on Hub2?	ConSurf1	ConSurf2
1	2x60	Lig	ccka_off	5.035	0	No	No	Yes	Yes	7	0
2	3x29	Lig	ccka_off	4.555	0	No	No	Yes	Yes	6	0
3	6x51	Lig	ccka_off	6.855	0	No	No	Yes	Yes	7	0
4	1x31	NT.K37	ccka_off	5.425	0	Yes	No	No	No	1	7
5	1x31	1x32	ccka_off	4.74	0	Yes	No	No	No	1	4
6	1x39	2x57	ccka_off	3.59	0	No	Yes	No	No	7	7
7	1x42	7x43	ccka_off	5.32	0	No	No	No	No	7	5
8	1x46	7x46	ccka_off	5.705	0	Yes	No	No	No	8	9
9	1x49	7x50	ccka_off	4.06	0	No	No	No	No	8	9
10	1x51	2x51	ccka_off	4.42	0	No	No	No	No	4	7
11	1x53	7x53	ccka_off	4.42	0	No	Yes	Yes	Yes	9	9
12	2x38	3x49	ccka_off	8.555	0	No	No	No	Yes	7	9
13	2x39	3x49	ccka_off	7.055	0	No	No	No	Yes	8	9
14	2x39	3x50	ccka_off	7.76	0	No	No	Yes	No	8	9
15	2x40	2x43	ccka_off	4.12	0	No	No	No	No	9	8
16	2x42	4x45	ccka_off	4.585	0	Yes	Yes	No	No	8	6
17	2x46	3x39	ccka_off	3.75	0	No	No	No	No	9	9
18	2x48	4x50	ccka_off	4.9	0	No	No	Yes	No	6	9
19	2x49	3x35	ccka_off	4.075	0	No	No	No	No	8	6
20	2x49	3x38	ccka_off	4.85	0	No	No	Yes	No	8	8
21	2x52	4x50	ccka_off	4.655	0	No	No	Yes	No	7	9
22	2x53	3x32	ccka_off	4.24	0	Yes	No	No	No	8	7
23	2x53	6x48	ccka_off	3.99	0	Yes	No	Yes	Yes	8	8
24	2x53	7x42	ccka_off	5.275	0	Yes	No	Yes	Yes	8	7
25	2x59	3x24	ccka_off	4.585	0	No	No	No	No	6	5
26	2x62	E1x52	ccka_off	4.395	0	No	No	Yes	Yes	5	6
27	2x63	E1x50	ccka_off	8.67	0	No	No	Yes	Yes	5	8
28	2x63	E1x52	ccka_off	4.33	0	No	No	Yes	Yes	5	6
29	2x64	7x35	ccka_off	3.725	0	No	No	No	No	6	5
30	2x66	E1x51	ccka_off	4.28	0	No	No	No	No	4	4
31	E1x49	E2.A193	ccka_off	6.18	0	No	No	No	No	4	3
32	E1x50	E2.L182	ccka_off	4.26	0	Yes	Yes	No	No	8	5
33	3x26	E2.N181	ccka_off	4.9	0	No	No	No	No	5	5
34	3x29	4x65	ccka_off	7.195	0	No	No	No	No	6	6
35	3x30	4x59	ccka_off	3.75	0	No	No	No	No	6	4
36	3x31	4x54	ccka_off	4.29	0	Yes	No	No	No	5	4
37	3x32	7x42	ccka_off	7.185	0	No	No	Yes	Yes	7	7
38	3x36	6x52	ccka_off	7.21	0	No	No	Yes	No	7	7
39	3x38	4x49	ccka_off	4.76	0	Yes	No	No	No	8	7
40	3x39	6x44	ccka_off	3.96	0	No	No	Yes	No	9	9
41	3x40	3x41	ccka_off	4.85	0	No	No	No	Yes	8	6
42	3x40	5x461	ccka_off	3.685	0	No	No	No	No	8	7
43	3x40	6x44	ccka_off	7.135	0	No	No	Yes	No	8	9
44	3x41	3x44	ccka_off	7.97	0	No	Yes	No	No	6	7
45	3x41	5x50	ccka_off	7.435	0	No	Yes	No	Yes	6	9
46	3x42	4x49	ccka_off	4.39	0	No	No	No	No	8	7
47	3x43	6x41	ccka_off	5.96	0	No	No	No	No	8	8
48	3x43	6x44	ccka_off	6.09	0	No	No	Yes	No	8	9
49	3x44	5x54	ccka_off	5.325	0	No	No	No	No	7	8
50	3x46	6x37	ccka_off	4.28	0	No	No	No	No	9	8
51	3x49	3x50	ccka_off	15.12	0	No	Yes	Yes	No	9	9
52	3x50	3x53	ccka_off	4.15	0	Yes	No	No	No	9	8
53	3x50	3x54	ccka_off	3.76	0	Yes	No	No	No	9	9
54	3x50	6x34	ccka_off	3.76	0	Yes	No	No	No	9	8
55	3x51	5x61	ccka_off	3.63	0	Yes	No	No	No	8	9
56	3x54	5x61	ccka_off	5.155	0	No	No	No	No	9	9
57	3x54	5x65	ccka_off	5.71	0	No	No	No	No	9	9
58	3x56	I2x53	ccka_off	6.885	0	Yes	Yes	No	No	6	8
59	4x41	4x44	ccka_off	7.205	0	Yes	Yes	No	No	7	4
60	4x61	5x39	ccka_off	12.06	0	Yes	Yes	Yes	No	7	8
61	4x64	E2.P201	ccka_off	9.74	0	No	No	No	No	5	5
62	E2.L199	E2x51	ccka_off	4.25	0	No	No	Yes	No	4	4
63	6x58	E2x51	ccka_off	19.195	0	No	No	Yes	No	4	4
64	E2x51	E3.E344	ccka_off	4.65	0	Yes	No	Yes	No	4	1
65	5x39	E2x52	ccka_off	7.02	0	Yes	No	Yes	Yes	8	5
66	5x36	E2.L200	ccka_off	9.985	0	No	No	Yes	Yes	5	4
67	5x35	E2.P201	ccka_off	8.39	0	No	No	No	No	4	5
68	5x43	6x52	ccka_off	4.87	0	No	No	Yes	No	7	7
69	5x461	5x47	ccka_off	3.655	0	No	No	Yes	No	7	8
70	5x47	6x52	ccka_off	11.785	0	Yes	No	Yes	No	8	7
71	5x51	6x45	ccka_off	3.765	0	No	No	Yes	No	6	6
72	5x54	6x41	ccka_off	7.61	0	No	No	No	No	8	8
73	5x58	6x34	ccka_off	3.63	0	Yes	Yes	No	No	9	8
74	5x58	6x38	ccka_off	8.46	0	Yes	Yes	No	No	9	7
75	5x61	6x34	ccka_off	6.625	0	No	No	No	No	9	8
76	5x65	6x31	ccka_off	6.345	0	No	No	No	No	9	6
77	6x27	6x28	ccka_off	4.24	0	No	No	No	No	4	5
78	6x28	6x31	ccka_off	4.32	0	No	No	No	No	5	6
79	6x36	6x40	ccka_off	4.37	0	No	No	No	No	9	9
80	6x36	7x53	ccka_off	3.59	0	No	No	Yes	Yes	9	9
81	6x40	7x49	ccka_off	10.62	0	No	No	Yes	Yes	9	9
82	6x44	6x45	ccka_off	3.75	0	Yes	No	Yes	No	9	6
83	6x45	6x49	ccka_off	8.085	0	Yes	No	No	No	6	6
84	6x48	7x41	ccka_off	7.415	0	Yes	Yes	No	No	8	7
85	6x51	7x41	ccka_off	6.19	0	No	No	No	No	7	7
86	6x57	E3.S342	ccka_off	3.71	0	Yes	Yes	No	No	5	4
87	E3.R345	E3.S342	ccka_off	3.95	0	No	No	No	No	5	4
88	7x48	7x49	ccka_off	3.695	0	No	No	Yes	Yes	7	9
89	4x39	I1x48	ccka_off	5.03	0	No	No	No	No	4	7
90	I1x49	I1x50	ccka_off	4.965	0	No	No	No	No	6	8
91	1x38	7x39	ccka_off	3.46	0	No	No	No	No	5	7
92	1x46	7x47	ccka_off	3.44	0	Yes	No	No	No	8	7
93	3x48	I2x56	ccka_off	3.415	0	No	No	No	No	6	5
94	1x35	2x65	ccka_off	3.325	0	No	No	No	No	4	5
95	6x50	7x40	ccka_off	3.28	0	No	No	No	No	9	8
96	1x54	2x47	ccka_off	3.25	0	No	No	No	No	7	9
97	6x24	6x28	ccka_off	3.22	0	No	No	No	No	4	5
98	E2.A193	E2.K187	ccka_off	3.21	0	No	No	Yes	No	3	2
99	6x42	6x46	ccka_off	2.98	0	No	No	No	No	6	5
100	5x40	6x56	ccka_off	2.925	0	No	No	No	No	6	6
101	3x51	3x52	ccka_off	2.9	0	Yes	No	No	No	8	6
102	2x38	I2x57	ccka_off	2.865	0	No	No	No	No	7	7
103	1x54	2x44	ccka_off	2.855	0	No	No	No	No	7	6
104	5x65	6x30	ccka_off	2.82	0	No	No	No	No	9	8
105	1x48	1x49	ccka_off	2.565	0	No	No	No	No	4	8
106	5x68	6x27	ccka_off	2.565	0	No	No	No	No	7	4
107	2x58	2x62	ccka_off	2.54	0	No	No	No	No	8	5
108	6x32	7x56	ccka_off	2.48	0	No	No	No	No	8	7
109	3x26	4x65	ccka_off	2.295	0	No	No	No	No	5	6
110	5x56	5x60	ccka_off	2.235	0	No	No	No	No	5	5
111	2x41	4x46	ccka_off	2.205	0	No	No	No	No	5	7
112	6x32	6x35	ccka_off	2.13	0	No	No	No	No	8	7
113	1x57	I1x50	ccka_off	2.12	0	No	No	No	No	7	8
114	8x47	8x48	ccka_off	2.1	0	No	No	No	No	9	6
115	6x54	Lig	ccka_off	1.94	0	No	No	Yes	Yes	5	0
116	5x44	5x47	ccka_off	1.83	0	No	No	Yes	No	7	8
117	1x49	1x52	ccka_off	1.71	0	No	No	No	No	8	7
118	5x34	5x38	ccka_off	1.62	0	No	No	No	No	2	4
119	5x62	6x38	ccka_off	1.55	0	No	No	No	No	6	7
120	6x61	E3.A341	ccka_off	1.54	0	No	No	No	No	4	1
121	6x49	6x53	ccka_off	1.53	0	No	No	No	No	6	6
122	5x37	6x59	ccka_off	1.52	0	No	No	No	No	4	6
123	3x21	E1x52	ccka_off	1.51	0	No	No	Yes	Yes	7	6
124	1x56	1x60	ccka_off	1.48	0	No	No	No	Yes	8	6
125	5x41	5x45	ccka_off	1.47	0	No	No	No	No	6	3
126	E3.E344	E3.S348	ccka_off	1.435	0	Yes	No	No	No	1	5
127	E2.K187	E2.N188	ccka_off	1.4	0	Yes	No	No	No	2	1
128	7x54	7x55	ccka_off	1.4	0	No	No	No	Yes	8	6
129	E2.K187	E2.Q191	ccka_off	1.36	0	Yes	No	No	No	2	2
130	1x43	1x44	ccka_off	1.22	0	Yes	Yes	No	No	5	4
131	7x47	7x51	ccka_off	0.82	0	No	No	No	No	7	6
132	4x38	I2x55	ccka_off	0.795	0	No	No	No	No	8	5
133	4x51	4x52	ccka_off	0.795	0	No	No	No	No	4	5
134	1x36	1x40	ccka_off	0.775	0	No	No	No	No	5	4
135	1x40	1x41	ccka_off	0.75	0	No	No	No	No	4	4
136	4x52	4x55	ccka_off	0.735	0	No	No	No	No	5	5
137	5x33	E3.T340	ccka_off	0.725	0	No	No	No	No	2	2
138	2x41	4x43	ccka_off	0.715	0	No	No	No	No	5	5
139	5x48	5x52	ccka_off	0.715	0	No	No	No	No	6	4
140	7x56	8x47	ccka_off	0.7	0	No	No	No	No	7	9
141	6x29	6x32	ccka_off	0.69	0	No	No	No	No	6	8
142	E2.N189	E2.N190	ccka_off	0.68	0	No	No	No	No	4	4
143	I2x54	I2x55	ccka_off	0.655	0	No	No	No	No	6	5
144	3x32	Lig	Shared	13.675	5.57	No	No	Yes	Yes	7	0
145	4x61	Lig	Shared	6.215	16.65	Yes	Yes	Yes	Yes	7	0
146	6x52	Lig	Shared	5.45	5.36	Yes	No	Yes	Yes	7	0
147	6x55	Lig	Shared	16.355	5.88	No	No	Yes	Yes	7	0
148	6x58	Lig	Shared	35.93	11.38	No	No	Yes	Yes	4	0
149	E3.L347	Lig	Shared	4.73	5.69	No	No	Yes	Yes	5	0
150	7x34	Lig	Shared	19.33	29.36	No	No	Yes	Yes	5	0
151	1x30	1x31	Shared	7.12	28.48	No	No	Yes	No	1	1
152	1x31	7x32	Shared	7.085	4.25	Yes	No	No	Yes	1	3
153	1x35	7x35	Shared	7.22	12.99	No	No	No	No	4	5
154	1x36	2x65	Shared	4.28	7.14	No	No	No	No	5	5
155	1x39	2x61	Shared	20.515	9.38	No	Yes	No	No	7	6
156	1x39	7x39	Shared	13.48	17.58	No	Yes	No	No	7	7
157	1x42	7x39	Shared	4.28	5.71	No	No	No	No	7	7
158	1x43	1x47	Shared	6.555	10.49	Yes	Yes	No	No	5	6
159	1x43	2x54	Shared	4.19	5.59	Yes	Yes	No	No	5	7
160	1x43	2x57	Shared	4.355	6.22	Yes	Yes	No	No	5	7
161	1x45	7x47	Shared	3.965	1.59	No	No	No	No	5	7
162	1x46	1x50	Shared	4.47	4.47	Yes	No	Yes	Yes	8	9
163	1x46	2x54	Shared	6.89	6.89	Yes	No	No	No	8	7
164	1x50	2x50	Shared	8.17	6.73	Yes	Yes	No	Yes	9	9
165	1x50	7x50	Shared	5.705	8.15	Yes	Yes	No	No	9	9
166	1x57	2x44	Shared	6.23	5.54	No	No	No	No	7	6
167	1x59	1x60	Shared	9.645	2.41	No	No	No	Yes	5	6
168	1x60	I1x50	Shared	4.205	2.8	No	Yes	No	No	6	8
169	I1x48	I1x51	Shared	18.565	12.38	No	No	No	No	7	8
170	2x37	2x40	Shared	7.31	7.31	No	No	No	No	7	9
171	2x41	4x39	Shared	4.36	2.91	No	No	No	No	5	4
172	2x42	3x45	Shared	8.32	4.16	Yes	Yes	No	No	8	8
173	2x42	3x46	Shared	5.02	3.77	Yes	Yes	No	No	8	9
174	2x42	4x46	Shared	6.91	5.02	Yes	Yes	No	No	8	7
175	2x43	7x53	Shared	9.38	3.52	No	No	Yes	Yes	8	9
176	2x45	3x42	Shared	8.94	7.45	No	No	No	No	9	8
177	2x45	4x46	Shared	7.74	6.19	No	No	No	No	9	7
178	2x45	4x50	Shared	6.18	3.71	No	No	Yes	No	9	9
179	2x46	7x49	Shared	4.12	8.24	No	No	Yes	Yes	9	9
180	2x49	3x39	Shared	4.075	4.89	No	No	No	No	8	9
181	2x50	7x46	Shared	5.96	4.42	No	Yes	No	No	9	9
182	2x51	2x55	Shared	5.54	2.77	No	No	No	No	7	5
183	2x52	3x31	Shared	8.71	3.73	No	No	Yes	No	7	5
184	2x53	3x35	Shared	8.26	9.01	Yes	No	No	No	8	6
185	2x551	3x31	Shared	12.325	23.58	No	No	Yes	No	5	5
186	2x56	7x42	Shared	4.03	12.1	No	No	Yes	Yes	7	7
187	2x57	7x42	Shared	16.76	3.59	No	No	Yes	Yes	7	7
188	2x59	E1x52	Shared	11.79	6.43	No	No	Yes	Yes	6	6
189	2x59	3x28	Shared	8.435	11.67	No	No	No	No	6	6
190	2x60	7x38	Shared	8.235	5.49	No	No	No	No	7	6
191	2x60	7x42	Shared	11.05	10.47	No	No	Yes	Yes	7	7
192	2x61	2x65	Shared	6.23	9.69	No	No	No	No	6	5
193	2x62	2x63	Shared	5.925	3.39	No	No	No	No	5	5
194	2x67	E2.K187	Shared	8.62	7.18	No	No	Yes	No	4	2
195	E1x49	E1x51	Shared	5.6	5.6	No	No	No	No	4	4
196	E1x50	E1x52	Shared	4.825	9.65	Yes	Yes	Yes	Yes	8	6
197	3x25	E1x50	Shared	4.19	5.59	No	No	Yes	Yes	9	8
198	E1x50	E2x50	Shared	10.475	8.38	Yes	Yes	No	No	8	9
199	3x24	E1x52	Shared	5.895	5.24	No	No	Yes	Yes	5	6
200	3x22	E2.L182	Shared	3.75	4.5	No	No	No	No	4	5
201	3x25	E2x50	Shared	7.28	7.28	No	No	No	No	9	9
202	3x29	4x61	Shared	6.865	3.75	No	No	Yes	Yes	6	7
203	3x30	4x54	Shared	10.315	8.25	No	No	No	No	6	4
204	3x30	4x62	Shared	15.995	9.74	No	No	No	No	6	6
205	3x34	4x54	Shared	14.27	6.49	No	No	No	No	6	4
206	3x36	6x48	Shared	7.97	4.9	No	No	Yes	Yes	7	8
207	3x37	4x53	Shared	6.52	3.26	No	No	No	No	7	8
208	3x38	3x42	Shared	3.695	4.43	Yes	No	No	No	8	8
209	3x38	4x50	Shared	12.87	18.39	Yes	No	Yes	No	8	9
210	3x38	4x53	Shared	4.85	3.23	Yes	No	No	No	8	8
211	3x47	5x54	Shared	6.9	7.67	No	Yes	No	No	9	8
212	3x47	5x58	Shared	6.36	3.82	No	Yes	Yes	Yes	9	9
213	3x51	3x55	Shared	8.06	10.75	Yes	No	No	No	8	7
214	3x51	3x56	Shared	4.78	13.14	Yes	No	Yes	Yes	8	6
215	3x51	5x60	Shared	8.21	8.21	Yes	No	No	No	8	5
216	3x56	I2x52	Shared	8.135	4.07	Yes	Yes	No	No	6	5
217	4x41	I2x56	Shared	12.7	8.46	Yes	Yes	No	No	7	5
218	4x41	4x45	Shared	4.155	6.92	Yes	Yes	No	No	7	6
219	4x57	4x61	Shared	4.19	4.79	No	Yes	Yes	Yes	8	7
220	4x59	4x60	Shared	4.375	5.25	No	No	No	No	4	8
221	4x60	5x39	Shared	9.46	9.46	No	No	Yes	No	8	8
222	4x61	E2x52	Shared	20.115	7.22	Yes	Yes	Yes	Yes	7	5
223	4x63	4x64	Shared	9.065	14.51	No	No	No	No	5	5
224	4x64	E2.L200	Shared	6.45	8.21	No	No	Yes	Yes	5	4
225	4x65	E2x52	Shared	4.62	3.96	No	No	Yes	Yes	6	5
226	E2.L182	E2.N194	Shared	13.04	6.87	No	No	No	No	5	3
227	E2.M195	E2.V183	Shared	4.56	3.04	No	Yes	No	No	4	3
228	E2.N194	E2.P184	Shared	4.89	6.52	No	No	No	No	3	1
229	E2.A193	E2.F185	Shared	4.16	4.16	No	No	No	No	3	4
230	E2.F185	E2.M195	Shared	4.355	8.71	No	No	No	Yes	4	4
231	E2.L200	E2x52	Shared	6.7	6.09	Yes	Yes	Yes	Yes	4	5
232	E2.L200	E2.P201	Shared	4.93	4.93	Yes	Yes	No	No	4	5
233	5x32	5x35	Shared	7.01	4.21	No	No	No	No	5	4
234	5x36	5x40	Shared	3.71	7.42	No	No	No	No	5	6
235	5x37	6x60	Shared	27.615	5.64	No	No	No	No	4	5
236	5x39	5x42	Shared	5.515	5.01	Yes	No	No	No	8	5
237	5x39	5x43	Shared	14.235	15.94	Yes	No	No	No	8	7
238	5x40	6x59	Shared	3.66	4.39	No	No	No	No	6	6
239	5x42	5x46	Shared	11.3	10.05	No	No	No	No	5	5
240	5x47	6x45	Shared	8.575	5.36	Yes	No	Yes	No	8	6
241	5x58	6x37	Shared	8.795	15.24	Yes	Yes	No	No	9	8
242	5x69	6x27	Shared	5.71	5.71	No	No	No	No	5	4
243	6x36	7x56	Shared	9.385	4.33	No	No	No	No	9	7
244	6x40	7x52	Shared	5.155	7.36	No	No	No	Yes	9	9
245	6x43	7x48	Shared	3.725	4.47	No	No	No	No	6	7
246	6x44	6x48	Shared	10.02	7.02	Yes	No	Yes	Yes	9	8
247	6x47	7x45	Shared	4.3	6.89	No	No	No	No	8	9
248	6x48	6x52	Shared	4.51	7.02	Yes	Yes	Yes	No	8	7
249	6x48	7x45	Shared	8.03	8.65	Yes	Yes	No	No	8	9
250	6x50	7x37	Shared	4.235	1.69	No	No	No	Yes	9	6
251	6x51	7x37	Shared	3.68	4.42	No	No	No	Yes	7	6
252	6x57	E3.A343	Shared	9.075	11.67	Yes	Yes	No	No	5	4
253	6x57	E3.R346	Shared	4	2	Yes	Yes	No	No	5	4
254	6x57	E3.L347	Shared	5.69	4.56	Yes	Yes	No	No	5	5
255	6x58	E3.E344	Shared	5.235	12.79	No	No	Yes	No	4	1
256	6x61	E3.S342	Shared	11.78	1.47	No	No	No	No	4	4
257	E3.E344	E3.T340	Shared	7.055	5.64	Yes	No	No	No	1	2
258	7x32	7x33	Shared	5.25	3.5	No	Yes	No	No	3	4
259	7x34	7x37	Shared	4.42	4.42	No	No	No	Yes	5	6
260	7x49	7x53	Shared	4.65	5.81	Yes	Yes	Yes	Yes	9	9
261	E1x51	E1x52	Shared	3.77	12.56	No	No	Yes	Yes	4	6
262	3x33	4x57	Shared	3.49	3.49	No	No	No	Yes	6	8
263	4x38	4x41	Shared	3.425	1.37	No	No	Yes	Yes	8	7
264	3x47	5x57	Shared	3.42	3.42	No	Yes	No	No	9	6
265	5x49	5x50	Shared	3.39	3.39	No	No	No	Yes	6	9
266	3x27	3x31	Shared	3.24	2.59	No	No	Yes	No	4	5
267	7x32	7x36	Shared	3.24	5.19	No	Yes	No	No	3	4
268	3x44	5x53	Shared	3.205	3.21	No	No	No	No	7	7
269	5x41	6x60	Shared	3.12	2.5	No	No	No	No	6	5
270	E2.M195	E2x51	Shared	3.1	16.13	No	Yes	Yes	No	4	4
271	1x30	1x34	Shared	3.065	3.68	No	No	No	No	1	5
272	3x55	5x64	Shared	3.04	6.08	No	No	No	No	7	6
273	1x34	1x38	Shared	2.98	2.98	No	No	No	No	5	5
274	6x39	6x43	Shared	2.98	4.47	No	No	No	No	7	6
275	4x56	4x57	Shared	2.915	4.37	No	No	No	Yes	6	8
276	2x42	4x42	Shared	2.77	4.16	Yes	Yes	No	No	8	7
277	1x50	2x51	Shared	2.745	5.49	Yes	Yes	No	No	9	7
278	1x53	2x47	Shared	2.545	3.39	No	Yes	No	No	9	9
279	7x51	7x55	Shared	2.51	3.77	No	No	No	Yes	6	6
280	4x38	4x40	Shared	2.4	4.8	No	No	No	No	8	5
281	1x32	NT.E38	Shared	2.36	4.72	No	No	No	No	4	3
282	6x33	6x37	Shared	2.235	2.98	No	No	No	No	9	8
283	5x32	5x34	Shared	2.22	5.91	No	No	No	No	5	2
284	1x54	1x58	Shared	2.205	2.94	No	No	No	No	7	3
285	5x45	5x48	Shared	2.075	2.77	No	No	No	No	3	6
286	7x31	7x33	Shared	2.03	2.03	No	No	No	No	3	4
287	5x59	5x62	Shared	1.86	3.71	No	No	No	No	1	6
288	3x56	I2x50	Shared	1.67	1.67	Yes	Yes	No	No	6	8
289	6x38	6x42	Shared	1.54	1.54	No	No	No	No	7	6
290	E2.T186	E2.T192	Shared	0.785	3.14	No	No	No	No	3	3
291	1x37	1x38	Shared	0.69	1.38	No	No	No	No	4	5
292	5x60	5x63	Shared	0.69	1.38	No	No	No	No	5	4
293	I2x51	I2x52	Shared	0.665	1.33	No	No	No	No	7	5
294	1x31	NT.E38	ccka_on	0	3.82	Yes	No	No	No	1	3
295	1x32	1x35	ccka_on	0	4.74	No	No	No	No	4	4
296	1x35	7x32	ccka_on	0	5.67	No	No	No	Yes	4	3
297	1x39	7x35	ccka_on	0	5.09	No	Yes	No	No	7	5
298	1x39	7x42	ccka_on	0	3.97	No	Yes	Yes	Yes	7	7
299	1x41	1x45	ccka_on	0	4.15	No	No	No	No	4	5
300	1x48	1x52	ccka_on	0	6.92	No	No	No	No	4	7
301	1x52	8x54	ccka_on	0	6.09	No	No	No	No	7	0
302	1x53	7x54	ccka_on	0	8.54	No	Yes	No	No	9	8
303	1x53	7x55	ccka_on	0	3.93	No	Yes	No	Yes	9	6
304	1x53	8x50	ccka_on	0	9.18	No	Yes	No	Yes	9	0
305	1x56	8x50	ccka_on	0	9.18	No	No	No	Yes	8	0
306	1x56	8x54	ccka_on	0	3.93	No	No	No	No	8	0
307	1x56	8x57	ccka_on	0	7.93	No	No	No	No	8	0
308	1x57	2x40	ccka_on	0	4.12	No	No	No	No	7	9
309	1x57	8x50	ccka_on	0	3.65	No	No	No	Yes	7	0
310	1x60	I1x49	ccka_on	0	12.05	No	Yes	No	No	6	6
311	1x60	8x57	ccka_on	0	5.85	No	Yes	No	No	6	0
312	2x44	I1x51	ccka_on	0	3.64	No	No	No	No	6	8
313	2x37	2x39	ccka_on	0	4.71	No	No	No	No	7	8
314	2x38	4x42	ccka_on	0	5.09	No	No	No	No	7	7
315	2x42	3x49	ccka_on	0	7	Yes	Yes	No	Yes	8	9
316	2x43	7x54	ccka_on	0	6.35	No	No	No	No	8	8
317	2x46	2x50	ccka_on	0	8.14	No	No	No	Yes	9	9
318	2x46	3x43	ccka_on	0	4.15	No	No	No	No	9	8
319	2x50	2x53	ccka_on	0	4.07	No	Yes	Yes	No	9	8
320	2x50	3x39	ccka_on	0	4.42	No	Yes	No	No	9	9
321	2x50	7x49	ccka_on	0	5.39	No	Yes	Yes	Yes	9	9
322	2x50	7x50	ccka_on	0	4.83	No	Yes	No	No	9	9
323	2x52	2x551	ccka_on	0	4.98	No	No	No	No	7	5
324	2x52	3x35	ccka_on	0	4.6	No	No	No	No	7	6
325	2x54	2x57	ccka_on	0	6.48	No	No	No	No	7	7
326	2x56	3x32	ccka_on	0	6.48	No	No	No	No	7	7
327	2x60	3x32	ccka_on	0	4.21	No	No	No	No	7	7
328	2x63	Lig	ccka_on	0	3.53	No	No	Yes	Yes	5	0
329	2x66	E1x49	ccka_on	0	9.5	No	No	No	No	4	4
330	3x24	E1x50	ccka_on	0	5.24	No	No	Yes	Yes	5	8
331	3x22	3x26	ccka_on	0	4.59	No	No	No	No	4	5
332	3x30	3x34	ccka_on	0	7.49	No	No	No	No	6	6
333	3x34	4x57	ccka_on	0	4.52	No	No	No	Yes	6	8
334	3x36	Lig	ccka_on	0	3.93	No	No	Yes	Yes	7	0
335	3x37	3x41	ccka_on	0	5.28	No	No	No	Yes	7	6
336	3x37	5x461	ccka_on	0	4.5	No	No	No	No	7	7
337	3x41	5x461	ccka_on	0	3.65	No	Yes	No	No	6	7
338	3x43	7x49	ccka_on	0	6.87	No	No	Yes	Yes	8	9
339	3x43	7x53	ccka_on	0	3.52	No	No	Yes	Yes	8	9
340	3x44	5x50	ccka_on	0	3.53	No	No	No	Yes	7	9
341	3x46	3x50	ccka_on	0	5.01	No	No	Yes	No	9	9
342	3x48	5x53	ccka_on	0	4.47	No	No	No	No	6	7
343	3x49	I2x56	ccka_on	0	8.72	No	Yes	No	No	9	5
344	3x49	I2x57	ccka_on	0	11.47	No	Yes	No	No	9	7
345	3x49	4x41	ccka_on	0	3.69	No	Yes	Yes	Yes	9	7
346	3x50	5x58	ccka_on	0	8.23	Yes	No	Yes	Yes	9	9
347	3x50	7x53	ccka_on	0	6.17	Yes	No	Yes	Yes	9	9
348	3x53	I2x57	ccka_on	0	4.55	No	No	No	No	8	7
349	I2x53	I2x57	ccka_on	0	8.66	No	No	No	No	8	7
350	4x50	4x54	ccka_on	0	8.02	Yes	No	No	No	9	4
351	E2.P184	E2.V183	ccka_on	0	3.53	No	No	No	No	1	3
352	E2.F185	Lig	ccka_on	0	6.99	No	No	Yes	Yes	4	0
353	E2.M195	Lig	ccka_on	0	6.46	No	Yes	Yes	Yes	4	0
354	E2x50	Lig	ccka_on	0	6.48	No	No	Yes	Yes	9	0
355	E2x51	Lig	ccka_on	0	22.92	Yes	No	Yes	Yes	4	0
356	E2x52	Lig	ccka_on	0	13.14	Yes	Yes	Yes	Yes	5	0
357	5x35	E2.L200	ccka_on	0	7.07	No	No	Yes	Yes	4	4
358	5x33	5x37	ccka_on	0	6.53	No	No	No	No	2	4
359	5x36	6x58	ccka_on	0	4.67	No	No	No	No	5	4
360	5x40	Lig	ccka_on	0	3.78	No	No	Yes	Yes	6	0
361	5x44	6x52	ccka_on	0	3.65	No	No	Yes	No	7	7
362	5x46	5x461	ccka_on	0	4.28	No	No	No	No	5	7
363	5x47	5x48	ccka_on	0	3.65	Yes	No	No	No	8	6
364	5x47	6x49	ccka_on	0	12.44	Yes	No	No	No	8	6
365	5x54	5x58	ccka_on	0	3.59	No	No	Yes	Yes	8	9
366	5x54	6x44	ccka_on	0	8.71	No	No	Yes	No	8	9
367	5x55	6x45	ccka_on	0	3.73	No	No	Yes	No	6	6
368	5x58	6x41	ccka_on	0	5.05	Yes	Yes	No	No	9	8
369	5x66	5x70	ccka_on	0	16.72	No	No	No	No	6	0
370	5x72	I3.S300	ccka_on	0	12.94	No	No	No	No	0	0
371	I3.N299	I3.S298	ccka_on	0	4.47	No	No	No	No	0	0
372	6x26	6x30	ccka_on	0	8.39	No	No	No	No	4	8
373	6x28	6x32	ccka_on	0	7.44	No	No	No	No	5	8
374	6x36	7x52	ccka_on	0	4.37	No	No	No	Yes	9	9
375	6x40	7x53	ccka_on	0	8.46	No	No	Yes	Yes	9	9
376	6x47	6x48	ccka_on	0	3.92	No	No	Yes	Yes	8	8
377	6x51	7x38	ccka_on	0	4.28	No	No	No	No	7	6
378	6x57	6x61	ccka_on	0	8.93	Yes	Yes	No	No	5	4
379	E3.E344	Lig	ccka_on	0	13.35	Yes	No	Yes	Yes	1	0
380	E3.S348	Lig	ccka_on	0	11.08	No	No	Yes	Yes	5	0
381	7x38	7x42	ccka_on	0	10.55	No	No	Yes	Yes	6	7
382	7x41	7x42	ccka_on	0	10.17	No	No	Yes	Yes	7	7
383	7x45	7x49	ccka_on	0	5.96	No	No	Yes	Yes	9	9
384	7x52	7x53	ccka_on	0	3.63	No	Yes	Yes	Yes	9	9
385	7x54	8x50	ccka_on	0	11.17	No	No	No	Yes	8	0
386	7x55	8x50	ccka_on	0	5.36	No	Yes	No	Yes	6	0
387	8x54	8x57	ccka_on	0	5.19	No	No	No	No	0	0
388	Lig	Lig	ccka_on	0	34.19	Yes	Yes	Yes	Yes	0	0
389	3x40	5x50	ccka_on	0	3.5	No	No	No	Yes	8	9
390	6x60	6x61	ccka_on	0	3.45	No	No	No	No	5	4
391	5x62	6x34	ccka_on	0	3.1	No	No	No	No	6	8
392	1x54	2x48	ccka_on	0	3.07	No	No	No	No	7	6
393	6x39	7x52	ccka_on	0	3.07	No	No	No	Yes	7	9
394	7x48	7x52	ccka_on	0	3.07	No	No	No	Yes	7	9
395	2x38	4x39	ccka_on	0	3.04	No	No	No	No	7	4
396	1x49	7x55	ccka_on	0	3.01	No	No	No	Yes	8	6
397	3x21	E1x50	ccka_on	0	3.01	No	No	Yes	Yes	7	8
398	2x44	2x48	ccka_on	0	2.98	No	No	No	No	6	6
399	5x65	6x33	ccka_on	0	2.98	No	No	No	No	9	9
400	6x42	6x43	ccka_on	0	2.98	No	No	No	No	6	6
401	1x52	1x55	ccka_on	0	2.95	No	No	No	No	7	4
402	2x64	Lig	ccka_on	0	2.95	No	No	Yes	Yes	6	0
403	5x52	5x55	ccka_on	0	2.92	No	No	No	No	4	6
404	5x69	6x30	ccka_on	0	2.91	No	No	No	No	5	8
405	1x43	2x58	ccka_on	0	2.89	Yes	Yes	No	No	5	8
406	2x58	2x59	ccka_on	0	2.89	No	No	No	No	8	6
407	5x61	5x65	ccka_on	0	2.85	No	No	No	No	9	9
408	5x61	6x37	ccka_on	0	2.85	No	No	No	No	9	8
409	5x65	6x34	ccka_on	0	2.85	No	No	No	No	9	8
410	E2.Q191	E2.T192	ccka_on	0	2.83	No	No	No	No	2	3
411	6x27	6x31	ccka_on	0	2.82	No	No	No	No	4	6
412	8x48	8x52	ccka_on	0	2.82	No	No	No	No	6	0
413	2x40	I1x50	ccka_on	0	2.8	No	No	No	No	9	8
414	2x67	NT.E38	ccka_on	0	2.7	No	No	No	No	4	3
415	6x41	6x45	ccka_on	0	2.62	No	No	Yes	No	8	6
416	3x41	4x49	ccka_on	0	2.59	No	Yes	No	No	6	7
417	6x28	6x35	ccka_on	0	2.48	No	No	No	No	5	7
418	8x48	8x51	ccka_on	0	2.48	No	No	No	No	6	0
419	3x41	4x52	ccka_on	0	2.44	No	Yes	No	No	6	5
420	5x50	5x51	ccka_on	0	2.03	No	Yes	No	No	9	6
421	8x53	8x56	ccka_on	0	1.95	No	No	No	No	0	0
422	3x52	I2x53	ccka_on	0	1.86	No	No	No	No	6	8
423	3x52	3x56	ccka_on	0	1.74	No	No	Yes	Yes	6	6
424	8x52	8x53	ccka_on	0	1.71	No	No	No	No	0	0
425	6x47	7x43	ccka_on	0	1.69	No	No	No	No	8	5
426	3x44	3x47	ccka_on	0	1.62	No	No	No	Yes	7	9
427	3x53	3x54	ccka_on	0	1.62	No	No	No	No	8	9
428	6x54	7x34	ccka_on	0	1.62	No	No	No	No	5	5
429	6x54	7x37	ccka_on	0	1.62	No	No	No	Yes	5	6
430	5x44	6x56	ccka_on	0	1.58	No	No	No	No	7	6
431	1x51	1x55	ccka_on	0	1.57	No	No	No	No	4	4
432	5x52	5x56	ccka_on	0	1.54	No	No	No	No	4	5
433	5x35	5x38	ccka_on	0	1.53	No	No	No	No	4	4
434	5x68	5x71	ccka_on	0	1.51	No	No	No	No	7	0
435	1x44	1x47	ccka_on	0	1.49	No	No	No	No	4	6
436	6x23	6x26	ccka_on	0	1.49	No	No	No	No	0	4
437	E2.N181	E2.V183	ccka_on	0	1.48	No	No	No	No	5	3
438	E2.N194	E2.T192	ccka_on	0	1.46	No	No	No	No	3	3
439	5x69	5x70	ccka_on	0	1.45	No	No	No	No	5	0
440	8x52	8x55	ccka_on	0	1.41	No	No	No	No	0	0
441	8x56	I1x49	ccka_on	0	1.38	No	No	No	No	0	6
442	2x43	8x47	ccka_on	0	1.37	No	No	No	No	8	9
443	5x71	I3.S298	ccka_on	0	1.32	No	No	No	No	0	0
444	E3.R345	Lig	ccka_on	0	1.24	No	No	Yes	Yes	5	0
445	5x71	5x72	ccka_on	0	1.17	No	No	No	No	0	0
446	1x59	8x58	ccka_on	0	1.07	No	No	No	No	5	0

Orange: nodes, hubs and links specific of ccka_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of ccka_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	ccka_off Avg Int. Strength	ccka_on Avg Int. Strength	ccka_off Num Of Links	ccka_on Num Of Links	ConSurf
1	1x31	ccka_off	6.0925	12.1833	4	3	1
2	1x46	ccka_off	5.12625	5.68	4	2	8
3	2x53	ccka_off	5.44125	6.54	4	2	8
4	3x31	ccka_off	7.14125	9.96667	4	3	5
5	3x38	ccka_off	6.205	8.68333	5	3	8
6	3x50	ccka_off	6.91	6.47	5	3	9
7	3x51	ccka_off	5.516	10.7	5	3	8
8	4x50	ccka_off	7.15125	10.04	4	3	9
9	E2.K187	ccka_off	3.6475	7.18	4	1	2
10	E2x51	ccka_off	7.79875	19.525	4	2	4
11	5x39	ccka_off	9.658	10.1367	5	3	8
12	5x47	ccka_off	6.46125	7.15	4	3	8
13	6x44	ccka_off	6.191	7.865	5	2	9
14	6x45	ccka_off	6.04375	3.90333	4	3	6
15	6x52	ccka_off	6.765	5.34333	5	3	7
16	E3.E344	ccka_off	4.59375	10.5933	4	3	1
17	Lig	Shared	10.9155	11.6248	11	21	0
18	1x43	Shared	4.08	6.2975	4	4	5
19	1x50	Shared	5.2725	6.21	4	4	9
20	2x42	Shared	5.521	4.822	5	5	8
21	E1x50	Shared	6.484	6.374	5	5	8
22	E1x52	Shared	5.21643	8.47	7	4	6
23	3x56	Shared	5.3675	5.155	4	4	6
24	4x41	Shared	6.87125	5.11	4	4	7
25	4x61	Shared	9.889	8.1025	5	4	7
26	E2x52	Shared	9.61375	7.6025	4	4	5
27	E2.L200	Shared	7.01625	6.575	4	4	4
28	5x58	Shared	6.81125	7.186	4	5	9
29	6x48	Shared	6.98917	6.302	6	5	8
30	6x57	Shared	5.61875	6.79	4	4	5
31	7x42	Shared	8.86	8.475	5	6	7
32	7x49	Shared	5.77125	6.454	4	5	9
33	7x53	Shared	5.51	5.185	4	6	9
34	1x39	ccka_on	12.5283	9.005	3	4	7
35	1x53	ccka_on	3.4825	6.26	2	4	9
36	1x60	ccka_on	5.11	5.7775	3	4	6
37	2x50	ccka_on	7.065	5.42857	2	7	9
38	3x41	ccka_on	6.75167	3.49	3	4	6
39	3x47	ccka_on	5.56	4.1325	3	4	9
40	3x49	ccka_on	10.2433	7.72	3	4	9
41	4x57	ccka_on	3.53167	4.2925	3	4	8
42	E2.M195	ccka_on	4.005	8.585	3	4	4
43	5x50	ccka_on	5.4125	3.1125	2	4	9
44	7x32	ccka_on	5.19167	4.6525	3	4	3
45	7x37	ccka_on	4.11167	3.0375	3	4	6
46	7x52	ccka_on	5.155	4.3	1	5	9
47	7x55	ccka_on	1.955	4.0175	2	4	6
48	8x50	ccka_on	0	7.708	0	5	0

Orange: nodes, hubs and links specific of ccka_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of ccka_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	ccka_off Recurrence	ccka_on Recurrence	ccka_off Hub1?	ccka_on Hub1?	ccka_off Hub2?	ccka_on Hub2?	ConSurf1	ConSurf2
1	3x32	7x42	ccka_off	24.9021	0	No	No	Yes	Yes	7	7
2	2x60	Lig	ccka_off	26.5409	0	No	No	Yes	Yes	7	0
3	1x30	1x34	ccka_off	21.3982	8.25251	No	No	No	No	1	5
4	1x34	1x38	ccka_off	23.7212	5.51172	No	No	No	No	5	5
5	1x38	7x39	ccka_off	28.3342	0	No	No	No	No	5	7
6	1x39	7x39	ccka_off	35.1708	5.51172	No	Yes	No	No	7	7
7	1x39	2x57	ccka_off	55.0847	0	No	Yes	No	No	7	7
8	2x61	2x65	ccka_off	16.7191	5.51172	No	No	No	No	6	5
9	1x39	2x61	ccka_off	19.0642	8.25251	No	Yes	No	No	7	6
10	1x43	2x57	ccka_off	48.546	4.98163	Yes	Yes	No	No	5	7
11	1x43	2x54	ccka_off	41.9081	5.19246	Yes	Yes	No	No	5	7
12	1x46	7x47	ccka_off	11.9958	0	Yes	No	No	No	8	7
13	1x53	7x53	ccka_off	21.5803	0	No	Yes	Yes	Yes	9	9
14	2x46	7x49	ccka_off	64.3602	1.81314	No	No	Yes	Yes	9	9
15	2x46	3x39	ccka_off	66.0211	0	No	No	No	No	9	9
16	2x49	3x39	ccka_off	29.2887	2.07216	No	No	No	No	8	9
17	2x49	3x35	ccka_off	50.8856	0	No	No	No	No	8	6
18	2x53	7x42	ccka_off	55.7192	0	Yes	No	Yes	Yes	8	7
19	3x39	6x44	ccka_off	52.7341	0	No	No	Yes	No	9	9
20	2x53	6x48	ccka_off	34.8507	0	Yes	No	Yes	Yes	8	8
21	1x54	2x44	ccka_off	13.8995	0	No	No	No	No	7	6
22	1x54	2x47	ccka_off	17.773	0	No	No	No	No	7	9
23	1x53	2x47	ccka_off	19.6932	2.08421	No	Yes	No	No	9	9
24	2x49	3x38	ccka_off	56.7842	0	No	No	Yes	No	8	8
25	2x41	4x46	ccka_off	14.1147	0	No	No	No	No	5	7
26	3x43	6x44	ccka_off	58.5885	0	No	No	Yes	No	8	9
27	3x43	6x41	ccka_off	57.6119	0	No	No	No	No	8	8
28	5x54	6x41	ccka_off	56.7069	0	No	No	No	No	8	8
29	3x47	5x58	ccka_off	57.2422	8.66815	No	Yes	Yes	Yes	9	9
30	5x58	6x34	ccka_off	55.2282	0	Yes	Yes	No	No	9	8
31	3x50	6x34	ccka_off	22.0162	0	Yes	No	No	No	9	8
32	2x42	4x45	ccka_off	25.4704	0	Yes	Yes	No	No	8	6
33	2x52	4x50	ccka_off	11.0909	0	No	No	Yes	No	7	9
34	4x60	5x39	ccka_off	12.0786	5.05391	No	No	Yes	No	8	8
35	4x59	4x60	ccka_off	10.7046	2.59623	No	No	No	No	4	8
36	6x58	Lig	ccka_off	57.8436	5.74664	No	No	Yes	Yes	4	0
37	6x58	E2x51	ccka_off	49.2027	0	No	No	Yes	No	4	4
38	E2.M195	E2x51	ccka_off	46.5541	0.0722848	No	Yes	Yes	No	4	4
39	E2.F185	E2.M195	ccka_off	43.3482	0.138546	No	No	No	Yes	4	4
40	E2.A193	E2.F185	ccka_off	41.6101	3.05403	No	No	No	No	3	4
41	E1x49	E2.A193	ccka_off	33.3113	0	No	No	No	No	4	3
42	E1x49	E1x51	ccka_off	31.5345	5.59605	No	No	No	No	4	4
43	E1x51	E1x52	ccka_off	27.9369	8.37901	No	No	Yes	Yes	4	6
44	5x47	6x52	ccka_off	10.1694	0	Yes	No	Yes	No	8	7
45	3x40	3x41	ccka_off	10.5225	0	No	No	No	Yes	8	6
46	3x50	3x54	ccka_off	13.8001	0	Yes	No	No	No	9	9
47	5x61	6x34	ccka_off	32.8919	0	No	No	No	No	9	8
48	3x51	5x61	ccka_off	19.329	0	Yes	No	No	No	8	9
49	3x54	5x61	ccka_off	14.1754	0	No	No	No	No	9	9
50	3x54	5x65	ccka_off	24.2234	0	No	No	No	No	9	9
51	4x41	4x45	ccka_off	22.6839	3.03596	Yes	Yes	No	No	7	6
52	4x61	E2x52	ccka_off	33.7141	3.18656	Yes	Yes	Yes	Yes	7	5
53	E2.L200	E2.P201	ccka_off	13.4304	2.42154	Yes	Yes	No	No	4	5
54	5x36	E2.L200	ccka_off	26.7009	0	No	No	Yes	Yes	5	4
55	5x35	E2.P201	ccka_off	10.8095	0	No	No	No	No	4	5
56	5x36	5x40	ccka_off	24.0799	3.03596	No	No	No	No	5	6
57	5x40	6x59	ccka_off	18.8048	3.04801	No	No	No	No	6	6
58	5x37	6x59	ccka_off	16.1507	0	No	No	No	No	4	6
59	5x37	6x60	ccka_off	13.4856	6.08999	No	No	No	No	4	5
60	5x43	6x52	ccka_off	18.0268	0	No	No	Yes	No	7	7
61	5x65	6x31	ccka_off	18.6007	0	No	No	No	No	9	6
62	6x28	6x31	ccka_off	15.5272	0	No	No	No	No	5	6
63	6x40	7x49	ccka_off	16.8019	0	No	No	Yes	Yes	9	9
64	6x36	6x40	ccka_off	13.1049	0	No	No	No	No	9	9
65	6x36	7x53	ccka_off	13.6125	0	No	No	Yes	Yes	9	9
66	6x36	7x56	ccka_off	22.717	2.09626	No	No	No	No	9	7
67	4x38	4x41	ccka_off	11.4275	6.0659	No	No	Yes	Yes	8	7
68	5x41	6x60	ccka_off	10.8095	3.04801	No	No	No	No	6	5
69	6x32	7x56	ccka_off	11.3557	0	No	No	No	No	8	7
70	2x53	3x32	ccka_off	22.9653	0	Yes	No	No	No	8	7
71	3x46	6x37	ccka_off	11.6758	0	No	No	No	No	9	8
72	5x39	5x43	ccka_off	15.9907	2.59623	Yes	No	No	No	8	7
73	5x39	E2x52	ccka_off	15.8693	0	Yes	No	Yes	Yes	8	5
74	2x60	7x42	Shared	27.0264	25.0346	No	No	Yes	Yes	7	7
75	1x30	1x31	Shared	19.0642	10.9813	No	No	Yes	No	1	1
76	2x57	7x42	Shared	100	23.0589	No	No	Yes	Yes	7	7
77	1x46	2x54	Shared	39.6733	22.2758	Yes	No	No	No	8	7
78	1x46	1x50	Shared	21.343	22.2878	Yes	No	Yes	Yes	8	9
79	7x49	7x53	Shared	41.108	100	Yes	Yes	Yes	Yes	9	9
80	2x53	3x35	Shared	51.2057	10.2644	Yes	No	No	No	8	6
81	6x44	6x48	Shared	88.7436	68.3573	Yes	No	Yes	Yes	9	8
82	6x48	6x52	Shared	56.3593	78.0194	Yes	Yes	Yes	No	8	7
83	6x52	Lig	Shared	48.6399	77.658	Yes	No	Yes	Yes	7	0
84	1x57	2x44	Shared	11.9461	12.3547	No	No	No	No	7	6
85	3x38	3x42	Shared	24.433	11.415	Yes	No	No	No	8	8
86	2x45	3x42	Shared	23.964	12.1981	No	No	No	No	9	8
87	2x45	4x46	Shared	51.3491	37.811	No	No	No	No	9	7
88	3x38	4x50	Shared	30.0888	23.0046	Yes	No	Yes	No	8	9
89	2x45	4x50	Shared	29.6529	27.4261	No	No	Yes	No	9	9
90	3x47	5x54	Shared	58.8755	14.0895	No	Yes	No	No	9	8
91	2x42	4x46	Shared	38.7519	37.7809	Yes	Yes	No	No	8	7
92	2x42	3x46	Shared	12.7849	79.2603	Yes	Yes	No	No	8	9
93	4x61	Lig	Shared	48.4191	37.4315	Yes	Yes	Yes	Yes	7	0
94	E1x50	E1x52	Shared	13.4525	12.7763	Yes	Yes	Yes	Yes	8	6
95	5x58	6x37	Shared	13.9381	26.3358	Yes	Yes	No	No	9	8
96	E2.L200	E2x52	Shared	47.2714	19.0772	Yes	Yes	Yes	Yes	4	5
97	E3.L347	Lig	Shared	15.2237	29.7151	No	No	Yes	Yes	5	0
98	6x57	E3.L347	Shared	13.5132	27.0466	Yes	Yes	No	No	5	5
99	3x32	Lig	Shared	47.001	58.894	No	No	Yes	Yes	7	0
100	1x31	7x32	ccka_on	9.61761	13.6498	Yes	No	No	Yes	1	3
101	1x35	7x32	ccka_on	0	24.2516	No	No	No	Yes	4	3
102	1x35	7x35	ccka_on	4.82812	37.0942	No	No	No	No	4	5
103	1x39	7x35	ccka_on	0	39.6904	No	Yes	No	No	7	5
104	1x39	7x42	ccka_on	0	55.0148	No	Yes	Yes	Yes	7	7
105	2x54	2x57	ccka_on	0	17.4568	No	No	No	No	7	7
106	1x50	2x50	ccka_on	2.44993	26.3418	Yes	Yes	No	Yes	9	9
107	2x50	7x49	ccka_on	0	42.3529	No	Yes	Yes	Yes	9	9
108	2x43	7x53	ccka_on	5.9979	74.61	No	No	Yes	Yes	8	9
109	2x43	7x54	ccka_on	0	71.321	No	No	No	No	8	8
110	7x54	8x50	ccka_on	0	60.2012	No	No	No	Yes	8	0
111	1x56	8x50	ccka_on	0	33.1667	No	No	No	Yes	8	0
112	1x56	8x57	ccka_on	0	21.312	No	No	No	No	8	0
113	1x57	8x50	ccka_on	0	21.33	No	No	No	Yes	7	0
114	1x60	8x57	ccka_on	0	19.8422	No	Yes	No	No	6	0
115	1x60	I1x49	ccka_on	0	14.3726	No	Yes	No	No	6	6
116	3x50	7x53	ccka_on	0	66.9177	Yes	No	Yes	Yes	9	9
117	3x46	3x50	ccka_on	0	81.4108	No	No	Yes	No	9	9
118	2x42	4x42	ccka_on	2.80307	12.0896	Yes	Yes	No	No	8	7
119	2x42	3x49	ccka_on	0	57.1773	Yes	Yes	No	Yes	8	9
120	2x56	7x42	ccka_on	2.41682	25.0587	No	No	Yes	Yes	7	7
121	2x56	3x32	ccka_on	0	27.2514	No	No	No	No	7	7
122	4x57	4x61	ccka_on	5.9041	37.2267	No	Yes	Yes	Yes	8	7
123	3x34	4x57	ccka_on	0	31.8234	No	No	No	Yes	6	8
124	3x34	4x54	ccka_on	2.10782	28.0465	No	No	No	No	6	4
125	4x50	4x54	ccka_on	0	29.4139	Yes	No	No	No	9	4
126	2x60	3x32	ccka_on	0	29.432	No	No	No	No	7	7
127	2x50	2x53	ccka_on	0	12.2824	No	Yes	Yes	No	9	8
128	E2x50	Lig	ccka_on	0	26.6249	No	No	Yes	Yes	9	0
129	E1x50	E2x50	ccka_on	1.94228	21.1192	Yes	Yes	No	No	8	9
130	E2.M195	Lig	ccka_on	0	32.6245	No	Yes	Yes	Yes	4	0
131	E2.M195	E2.V183	ccka_on	1.95884	29.9922	No	Yes	No	No	4	3
132	E2.P184	E2.V183	ccka_on	0	24.0889	No	No	No	No	1	3
133	E2.N194	E2.P184	ccka_on	1.96987	21.1192	No	No	No	No	3	1
134	3x36	Lig	ccka_on	0	75.8749	No	No	Yes	Yes	7	0
135	3x36	6x48	ccka_on	1.42361	75.9533	No	No	Yes	Yes	7	8
136	3x38	4x53	ccka_on	4.04458	30.2934	Yes	No	No	No	8	8
137	3x37	4x53	ccka_on	2.02505	27.8236	No	No	No	No	7	8
138	3x37	5x461	ccka_on	0	17.6977	No	No	No	No	7	7
139	5x54	6x44	ccka_on	0	66.9538	No	No	Yes	No	8	9
140	3x44	3x47	ccka_on	0	17.7881	No	No	No	Yes	7	9
141	3x44	5x50	ccka_on	0	10.2343	No	No	No	Yes	7	9
142	5x54	5x58	ccka_on	0	52.0812	No	No	Yes	Yes	8	9
143	3x49	I2x57	ccka_on	0	41.0337	No	Yes	No	No	9	7
144	3x49	4x41	ccka_on	0	11.6981	No	Yes	Yes	Yes	9	7
145	I2x53	I2x57	ccka_on	0	32.3414	No	No	No	No	8	7
146	3x52	I2x53	ccka_on	0	29.4199	No	No	No	No	6	8
147	3x52	3x56	ccka_on	0	26.4864	No	No	Yes	Yes	6	6
148	3x51	3x56	ccka_on	8.24367	14.6316	Yes	No	Yes	Yes	8	6
149	5x46	5x461	ccka_on	0	15.2943	No	No	No	No	5	7
150	5x42	5x46	ccka_on	1.93125	12.7522	No	No	No	No	5	5
151	5x39	5x42	ccka_on	3.85698	10.1982	Yes	No	No	No	8	5
152	E2x52	Lig	ccka_on	0	20.3301	Yes	Yes	Yes	Yes	5	0
153	6x57	6x61	ccka_on	0	18.1375	Yes	Yes	No	No	5	4
154	6x60	6x61	ccka_on	0	12.1378	No	No	No	No	5	4
155	5x58	6x41	ccka_on	0	22.33	Yes	Yes	No	No	9	8
156	6x41	6x45	ccka_on	0	19.8964	No	No	Yes	No	8	6
157	5x47	6x45	ccka_on	4.09976	10.0416	Yes	No	Yes	No	8	6
158	6x33	6x37	ccka_on	1.53948	11.8125	No	No	No	No	9	8
159	5x65	6x34	ccka_on	0	14.8786	No	No	No	No	9	8
160	5x61	6x37	ccka_on	0	12.0896	No	No	No	No	9	8
161	7x52	7x53	ccka_on	0	21.9987	No	Yes	Yes	Yes	9	9
162	6x48	7x45	ccka_on	4.05562	83.2902	Yes	Yes	No	No	8	9
163	7x34	Lig	ccka_on	5.69994	13.1378	No	No	Yes	Yes	5	0
164	8x56	I1x49	ccka_on	0	12.3547	No	No	No	No	0	6
165	8x53	8x56	ccka_on	0	10.3247	No	No	No	No	0	0
166	1x32	1x35	ccka_on	0	10.2765	No	No	No	No	4	4
167	7x45	7x49	ccka_on	0	83.6576	No	No	Yes	Yes	9	9
168	3x50	5x58	ccka_on	0	46.3406	Yes	No	Yes	Yes	9	9

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
2x60	Lig	ccka_off	5.035	0	0	1	1	0
3x29	Lig	ccka_off	4.555	0	1	0	1	0
3x32	Lig	Shared	13.675	5.57	1	1	1	0
4x61	Lig	Shared	6.215	16.65	1	1	1	0
6x51	Lig	ccka_off	6.855	0	0	0	1	0
6x52	Lig	Shared	5.45	5.36	1	1	1	0
6x55	Lig	Shared	16.355	5.88	0	0	1	0
6x58	Lig	Shared	35.93	11.38	1	1	1	0
E3.L347	Lig	Shared	4.73	5.69	0	1	1	0
7x34	Lig	Shared	19.33	29.36	0	1	1	0
2x53	3x32	ccka_off	4.24	0	1	0	2	1
2x53	6x48	ccka_off	3.99	0	1	0	2	2
2x53	7x42	ccka_off	5.275	0	1	0	2	2
2x56	7x42	Shared	4.03	12.1	0	0	2	2
2x60	7x38	Shared	8.235	5.49	0	1	1	2
2x60	7x42	Shared	11.05	10.47	0	1	1	2
2x62	2x63	Shared	5.925	3.39	2	0	2	1
2x62	E1x52	ccka_off	4.395	0	2	0	2	2
2x63	E1x50	ccka_off	8.67	0	2	1	1	2
2x63	E1x52	ccka_off	4.33	0	2	1	1	2
2x64	7x35	ccka_off	3.725	0	0	0	1	2
E1x50	E1x52	Shared	4.825	9.65	2	1	2	2
3x25	E1x50	Shared	4.19	5.59	2	1	2	2
E1x50	E2x50	Shared	10.475	8.38	2	1	2	1
3x25	E2x50	Shared	7.28	7.28	2	1	2	1
3x29	4x61	Shared	6.865	3.75	1	0	1	1
3x29	4x65	ccka_off	7.195	0	1	0	1	2
3x32	7x42	ccka_off	7.185	0	1	1	1	2
3x36	6x48	Shared	7.97	4.9	1	1	1	2
3x36	6x52	ccka_off	7.21	0	1	1	1	1
4x57	4x61	Shared	4.19	4.79	0	0	2	1
4x61	E2x52	Shared	20.115	7.22	1	1	1	1
4x61	5x39	ccka_off	12.06	0	1	1	1	2
4x65	E2x52	Shared	4.62	3.96	0	0	2	1
E2.M195	E2.V183	Shared	4.56	3.04	0	1	1	2
E2.A193	E2.F185	Shared	4.16	4.16	0	0	2	1
E2.F185	E2.M195	Shared	4.355	8.71	0	1	1	1
E2.L199	E2x51	ccka_off	4.25	0	0	0	2	1
6x58	E2x51	ccka_off	19.195	0	1	1	1	1
E2x51	E3.E344	ccka_off	4.65	0	1	1	1	1
E2.L200	E2x52	Shared	6.7	6.09	1	0	2	1
5x39	E2x52	ccka_off	7.02	0	1	0	2	1
5x36	E2.L200	ccka_off	9.985	0	0	0	2	2
5x36	5x40	Shared	3.71	7.42	0	0	2	1
5x39	5x43	Shared	14.235	15.94	1	0	2	2
5x40	6x59	Shared	3.66	4.39	0	1	1	2
5x43	6x52	ccka_off	4.87	0	0	0	2	1
5x47	6x52	ccka_off	11.785	0	0	0	2	1
6x48	6x52	Shared	4.51	7.02	1	1	2	1
6x48	7x41	ccka_off	7.415	0	1	1	2	2
6x51	7x37	Shared	3.68	4.42	0	0	1	2
6x51	7x41	ccka_off	6.19	0	0	0	1	2
6x57	E3.S342	ccka_off	3.71	0	0	0	2	2
6x57	E3.L347	Shared	5.69	4.56	0	0	2	1
6x58	E3.E344	Shared	5.235	12.79	1	1	1	1
E3.E344	E3.T340	Shared	7.055	5.64	1	1	1	2
E3.R345	E3.S342	ccka_off	3.95	0	0	0	1	2
7x34	7x37	Shared	4.42	4.42	0	1	1	2
E2.M195	E2x51	Shared	3.1	16.13	0	1	1	1
5x40	6x56	ccka_off	2.925	0	0	1	1	2
6x54	Lig	ccka_off	1.94	0	0	1	1	0
5x44	5x47	ccka_off	1.83	0	0	0	2	2
E3.E344	E3.S348	ccka_off	1.435	0	1	1	1	1
2x56	3x32	ccka_on	0	6.48	0	0	2	1
2x60	3x32	ccka_on	0	4.21	0	1	1	1
2x63	Lig	ccka_on	0	3.53	2	1	1	0
3x36	Lig	ccka_on	0	3.93	1	1	1	0
E2.F185	Lig	ccka_on	0	6.99	0	1	1	0
E2.M195	Lig	ccka_on	0	6.46	0	1	1	0
E2x50	Lig	ccka_on	0	6.48	2	1	1	0
E2x51	Lig	ccka_on	0	22.92	1	1	1	0
E2x52	Lig	ccka_on	0	13.14	1	1	1	0
5x36	6x58	ccka_on	0	4.67	0	0	2	1
5x40	Lig	ccka_on	0	3.78	0	1	1	0
5x44	6x52	ccka_on	0	3.65	0	0	2	1
6x51	7x38	ccka_on	0	4.28	0	0	1	2
E3.E344	Lig	ccka_on	0	13.35	1	1	1	0
E3.S348	Lig	ccka_on	0	11.08	0	0	1	0
7x38	7x42	ccka_on	0	10.55	0	1	2	2
7x41	7x42	ccka_on	0	10.17	0	0	2	2
2x64	Lig	ccka_on	0	2.95	0	0	1	0
6x54	7x34	ccka_on	0	1.62	0	1	1	1
6x54	7x37	ccka_on	0	1.62	0	1	1	2
5x44	6x56	ccka_on	0	1.58	0	0	2	2
E3.R345	Lig	ccka_on	0	1.24	0	0	1	0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	ccka_off	7F8Y-CCK_A-Devazepide 7F8U-CCK_A-Lintitript
	ccka_on	7EZH-CCK_A-Cholecystokinin-8-Gi1/β1/γ2

Network Difference
Value	ccka_off	ccka_on
I_min	3.58	3.52
Number of Linked Nodes	269	271
Number of Specific Nodes	18 (6.69%)	20 (7.38%)
Number of Shared Nodes	251 (93.31%)	251 (92.62%)
Number of Links	293	303
Number of Specific Links	143 (48.81%)	153 (50.50%)
Number of Shared Links	150 (51.19%)	150 (49.51%)
Number of Hubs	33	32
Number of Specific Hubs	16 (48.48%)	15 (46.88%)
Number of Shared Hubs	17 (51.52%)	17 (53.13%)
Average % Shared Neighbours (Jaccard)	36.57
Average % Shared Neighbours (Otsuka)	46.14
Average % Shared Neighbours (Overlap Coefficient)	55.69
Average % Shared Cliques (k3-6)	75.74
Graphlets Similarity	0.531134

Paths Difference
Value	ccka_off	ccka_on
Number Of Nodes in MetaPath	92	91
Specific Nodes in MetaPath	43 (46.74%)	42 (46.15%)
Shared Nodes in MetaPath	251 (93.31%)	251 (93.31%)
Number Of Links MetaPath	99	95
Specific Links in MetaPath	73 (73.74%)	69 (72.63%)
Shared Links in MetaPath	150 (51.19%)	150 (51.19%)
Number of Shortest Paths	53213	54720
Length Of Smallest Path	3	3
Average Path Length	13.7186	12.4941
Length of Longest Path	29	29
Minimum Path Strength	0.725	1.245
Average Path Strength	6.97515	6.24879
Maximum Path Strength	26.1425	18.9
Minimum Path Correlation	0.7	0.7
Average Path Correlation	0.92504	0.931433
Maximum Path Correlation	0.99	0.99
Minimum % Of Corr. Nodes	4.54545	4.16667
Average % Of Corr. Nodes	49.5351	53.9875
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	36.4326	37.5824
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

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