psnGPCR

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Orange: nodes, hubs and links specific of ccr5_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of ccr5_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	ccr5_off Int. Strength	ccr5_on Int. Strength	ccr5_off Hub1?	ccr5_on Hub1?	ccr5_off Hub2?	ccr5_on Hub2?	ConSurf1	ConSurf2
1	7x28	NT.C20	ccr5_off	4.72	0	No	No	No	No	1	9
2	Lig	NT.C20	ccr5_off	4.19	0	Yes	Yes	No	No	0	9
3	1x28	E2.H175	ccr5_off	5.24	0	No	No	No	No	1	1
4	1x31	Lig	ccr5_off	4.73	0	No	No	Yes	Yes	5	0
5	1x35	7x39	ccr5_off	5.9	0	No	No	No	No	6	6
6	1x49	7x50	ccr5_off	4.06	0	No	No	No	No	8	9
7	1x51	2x51	ccr5_off	5.65	0	No	No	No	No	3	7
8	1x53	7x53	ccr5_off	5.05	0	No	No	Yes	Yes	8	9
9	1x54	2x44	ccr5_off	4.28	0	No	No	No	No	7	6
10	1x56	8x53	ccr5_off	4.84	0	No	No	No	No	7	5
11	1x60	CT.K314	ccr5_off	15.53	0	Yes	No	No	No	5	6
12	2x37	2x40	ccr5_off	7.36	0	No	No	No	No	7	8
13	2x43	3x46	ccr5_off	4.15	0	No	No	No	No	8	9
14	2x43	7x53	ccr5_off	4.69	0	No	No	Yes	Yes	8	9
15	2x52	4x50	ccr5_off	9.02	0	No	No	Yes	Yes	7	9
16	2x54	7x46	ccr5_off	4.76	0	No	No	No	No	6	8
17	2x56	2x60	ccr5_off	9.7	0	No	No	Yes	Yes	7	7
18	2x60	3x32	ccr5_off	5.79	0	Yes	Yes	Yes	Yes	7	7
19	2x60	7x42	ccr5_off	4.65	0	Yes	Yes	No	Yes	7	8
20	2x62	E1x51	ccr5_off	8.82	0	No	No	No	No	5	3
21	2x63	E2x50	ccr5_off	4.03	0	Yes	Yes	No	No	4	9
22	E1x49	E2.Y176	ccr5_off	12.4	0	No	No	No	No	3	4
23	3x22	E2.S169	ccr5_off	7.45	0	Yes	No	No	No	3	4
24	3x24	3x28	ccr5_off	4.24	0	No	No	No	No	6	5
25	3x37	4x56	ccr5_off	4.16	0	Yes	Yes	No	No	7	5
26	3x37	4x57	ccr5_off	5.28	0	Yes	Yes	No	No	7	7
27	3x37	5x46	ccr5_off	4.87	0	Yes	Yes	No	No	7	4
28	3x40	3x43	ccr5_off	4.42	0	Yes	No	No	No	7	8
29	3x40	3x44	ccr5_off	4.42	0	Yes	No	Yes	No	7	7
30	3x40	5x50	ccr5_off	6.77	0	Yes	No	Yes	No	7	9
31	3x42	4x46	ccr5_off	3.96	0	Yes	Yes	No	No	7	7
32	3x43	6x40	ccr5_off	4.42	0	No	No	No	No	8	8
33	3x43	6x41	ccr5_off	4.37	0	No	No	Yes	No	8	8
34	3x47	6x41	ccr5_off	4.52	0	No	No	Yes	No	9	8
35	3x50	3x53	ccr5_off	4.15	0	No	No	No	No	9	8
36	3x50	6x33	ccr5_off	15.48	0	No	No	No	No	9	8
37	3x51	3x56	ccr5_off	4.36	0	Yes	No	No	No	8	6
38	3x51	5x61	ccr5_off	4.84	0	Yes	No	Yes	No	8	8
39	3x54	6x30	ccr5_off	6.54	0	No	No	No	No	8	7
40	I2x54	I2x55	ccr5_off	12.69	0	No	No	No	No	4	3
41	4x60	5x39	ccr5_off	6.32	0	No	No	Yes	No	8	5
42	4x61	5x39	ccr5_off	9.24	0	No	No	Yes	No	4	5
43	4x61	5x42	ccr5_off	5.6	0	No	No	No	No	4	3
44	4x64	5x39	ccr5_off	7.03	0	Yes	Yes	Yes	No	5	5
45	4x65	Lig	ccr5_off	6.99	0	No	No	Yes	Yes	5	0
46	E2.E172	E2.Q170	ccr5_off	12.74	0	No	No	No	No	2	1
47	E2.K171	Lig	ccr5_off	10.8	0	No	No	Yes	Yes	2	0
48	E2.E172	E2.T177	ccr5_off	16.93	0	No	No	No	No	2	2
49	E2.G173	Lig	ccr5_off	5.12	0	No	No	Yes	Yes	1	0
50	E2.H181	E2x51	ccr5_off	5.58	0	No	No	No	No	4	3
51	E2.F182	E2x52	ccr5_off	6.61	0	Yes	Yes	No	No	5	4
52	5x36	E2.F182	ccr5_off	6.2	0	No	No	Yes	Yes	4	5
53	5x35	E2.P183	ccr5_off	8.11	0	Yes	Yes	No	No	3	3
54	E2.S185	E2.Y184	ccr5_off	6.36	0	No	No	No	No	3	1
55	5x33	5x37	ccr5_off	11.88	0	No	No	No	No	2	3
56	5x34	5x38	ccr5_off	4.29	0	No	No	No	No	1	3
57	5x39	5x42	ccr5_off	6.78	0	Yes	No	No	No	5	3
58	5x40	6x55	ccr5_off	4.42	0	No	No	No	Yes	5	6
59	5x50	6x45	ccr5_off	5.78	0	Yes	No	Yes	No	9	5
60	5x54	6x41	ccr5_off	5.78	0	No	No	Yes	No	8	8
61	5x54	6x45	ccr5_off	4.98	0	No	No	Yes	No	8	5
62	5x58	6x38	ccr5_off	10.32	0	Yes	Yes	No	No	9	5
63	5x62	5x66	ccr5_off	5.54	0	No	No	No	No	4	4
64	5x65	6x31	ccr5_off	5.14	0	No	No	No	No	8	5
65	5x65	6x34	ccr5_off	4.47	0	No	No	No	No	8	6
66	6x29	6x32	ccr5_off	17.33	0	No	No	No	No	6	7
67	6x29	6x33	ccr5_off	16.59	0	No	No	No	No	6	8
68	6x32	8x48	ccr5_off	11.63	0	No	No	No	No	7	5
69	6x35	7x56	ccr5_off	3.92	0	No	No	No	No	5	7
70	6x36	6x37	ccr5_off	4.28	0	No	No	No	No	8	8
71	6x38	6x42	ccr5_off	6.28	0	No	No	No	No	5	5
72	6x39	7x52	ccr5_off	4.56	0	No	No	No	No	5	8
73	6x40	7x53	ccr5_off	4.84	0	No	No	Yes	Yes	8	9
74	6x41	6x45	ccr5_off	6.22	0	Yes	No	Yes	No	8	5
75	6x44	6x45	ccr5_off	5.16	0	Yes	Yes	Yes	No	9	5
76	6x47	7x48	ccr5_off	10.05	0	No	Yes	No	No	8	6
77	6x48	6x51	ccr5_off	6.75	0	Yes	Yes	Yes	No	9	7
78	6x58	6x61	ccr5_off	6.6	0	No	No	No	No	4	4
79	6x61	E3.N267	ccr5_off	3.96	0	No	No	Yes	No	4	3
80	6x63	6x64	ccr5_off	11.79	0	No	No	No	No	1	1
81	7x30	E3.L266	ccr5_off	5.54	0	No	No	No	No	5	4
82	7x35	7x38	ccr5_off	11.47	0	No	No	No	No	3	6
83	7x35	7x39	ccr5_off	5.67	0	No	No	No	No	3	6
84	7x38	Lig	ccr5_off	7.37	0	No	No	Yes	Yes	6	0
85	7x45	7x48	ccr5_off	5.3	0	Yes	No	No	No	9	6
86	7x45	7x49	ccr5_off	5.1	0	Yes	No	No	Yes	9	9
87	7x53	8x50	ccr5_off	5.16	0	Yes	Yes	Yes	Yes	9	8
88	8x50	8x54	ccr5_off	4.87	0	Yes	Yes	No	No	8	6
89	8x57	CT.H315	ccr5_off	15.84	0	No	No	No	No	4	2
90	1x39	2x57	ccr5_off	3.79	0	Yes	Yes	No	No	8	7
91	1x60	8x56	ccr5_off	3.79	0	Yes	No	No	No	5	4
92	7x56	8x47	ccr5_off	3.68	0	No	No	No	No	7	8
93	4x55	4x59	ccr5_off	3.65	0	No	No	No	No	4	4
94	5x54	5x58	ccr5_off	3.59	0	No	No	Yes	Yes	8	9
95	1x38	1x39	ccr5_off	3.52	0	No	No	Yes	Yes	6	8
96	3x25	E2.S169	ccr5_off	3.44	0	No	No	No	No	9	4
97	8x47	8x48	ccr5_off	3.27	0	No	No	No	No	8	5
98	8x57	8x58	ccr5_off	3.22	0	No	No	No	No	4	5
99	1x42	7x43	ccr5_off	3.17	0	No	No	No	No	7	5
100	6x39	7x56	ccr5_off	3.17	0	No	No	No	No	5	7
101	1x35	2x64	ccr5_off	3.15	0	No	No	No	No	6	5
102	2x41	4x39	ccr5_off	3.07	0	No	No	No	No	7	2
103	5x61	6x34	ccr5_off	3.07	0	Yes	No	No	No	8	6
104	1x53	1x57	ccr5_off	2.98	0	No	No	No	No	8	7
105	1x38	7x43	ccr5_off	2.95	0	No	No	No	No	6	5
106	1x54	1x58	ccr5_off	2.94	0	No	No	No	No	7	3
107	2x62	2x66	ccr5_off	2.93	0	No	No	No	No	5	4
108	8x56	8x59	ccr5_off	2.87	0	No	No	No	No	4	3
109	1x30	1x34	ccr5_off	2.85	0	No	No	No	No	2	6
110	3x48	3x52	ccr5_off	2.85	0	No	No	No	No	7	5
111	5x43	6x52	ccr5_off	2.83	0	No	No	No	No	5	8
112	3x21	E1x50	ccr5_off	2.81	0	No	No	Yes	Yes	8	9
113	1x52	8x54	ccr5_off	2.77	0	No	No	No	No	6	6
114	1x50	2x51	ccr5_off	2.75	0	No	No	No	No	9	7
115	1x25	1x29	ccr5_off	2.74	0	No	No	No	No	3	2
116	3x26	4x62	ccr5_off	2.74	0	No	No	No	No	7	4
117	I1x49	I1x51	ccr5_off	2.48	0	No	No	No	No	5	7
118	6x64	E3.L266	ccr5_off	2.44	0	No	No	No	No	1	4
119	5x461	5x50	ccr5_off	2.03	0	No	No	Yes	No	6	9
120	1x46	7x47	ccr5_off	1.96	0	No	No	No	No	8	8
121	6x49	6x50	ccr5_off	1.87	0	No	No	No	No	6	9
122	3x35	3x38	ccr5_off	1.86	0	No	No	No	No	8	7
123	6x65	E3.N267	ccr5_off	1.7	0	No	No	Yes	No	4	3
124	8x47	8x49	ccr5_off	1.64	0	No	No	No	No	8	6
125	NT.S17	NT.T16	ccr5_off	1.6	0	No	No	No	No	4	2
126	5x44	5x48	ccr5_off	1.6	0	No	No	No	No	5	4
127	4x44	4x45	ccr5_off	1.59	0	No	No	No	No	1	6
128	1x45	1x46	ccr5_off	1.51	0	No	No	No	No	5	8
129	3x22	3x23	ccr5_off	1.46	0	Yes	No	No	No	3	3
130	3x24	3x27	ccr5_off	1.41	0	No	No	No	No	6	5
131	5x65	5x66	ccr5_off	1.38	0	No	No	No	No	8	4
132	4x41	4x44	ccr5_off	1.31	0	No	No	No	No	3	1
133	E2.H175	E2.L174	ccr5_off	1.29	0	No	No	No	No	1	4
134	6x28	6x32	ccr5_off	1.24	0	No	No	No	No	5	7
135	5x67	I3.E227	ccr5_off	1.16	0	No	No	No	No	5	3
136	Lig	NT.S17	Shared	11.04	3.26	Yes	Yes	No	No	0	4
137	Lig	NT.P19	Shared	22.31	13.22	Yes	Yes	No	No	0	4
138	7x24	NT.C20	Shared	7.28	7.28	No	No	No	No	6	9
139	1x24	1x27	Shared	10.62	3.795	No	Yes	No	No	3	1
140	1x24	1x28	Shared	4.31	4.31	No	Yes	No	No	3	1
141	1x24	Lig	Shared	9.87	5.41	No	Yes	Yes	Yes	3	0
142	1x25	1x26	Shared	4.25	1.415	No	No	No	No	3	1
143	1x27	7x32	Shared	7.16	5.015	No	No	No	No	1	1
144	1x28	Lig	Shared	4.23	12.945	No	No	Yes	Yes	1	0
145	1x35	1x39	Shared	9.38	13.48	No	No	Yes	Yes	6	8
146	1x36	1x37	Shared	5.84	5.84	No	No	No	No	6	5
147	1x39	7x39	Shared	11.24	4.37	Yes	Yes	No	No	8	6
148	1x39	7x42	Shared	14.37	6.585	Yes	Yes	No	Yes	8	8
149	1x41	1x45	Shared	8.53	2.435	No	No	No	No	5	5
150	1x43	2x58	Shared	13	13.725	No	No	No	No	7	9
151	1x47	1x51	Shared	7.46	5.595	No	Yes	No	No	6	3
152	1x50	2x50	Shared	12.12	10.77	No	No	No	Yes	9	9
153	1x50	7x50	Shared	9.77	8.145	No	No	No	No	9	9
154	1x53	8x50	Shared	3.93	5.895	No	No	Yes	Yes	8	8
155	1x56	8x50	Shared	6.28	10.045	No	No	Yes	Yes	7	8
156	1x58	1x59	Shared	7.08	4.245	No	No	No	No	3	4
157	1x60	8x57	Shared	7.22	2.795	Yes	No	No	No	5	4
158	2x40	I1x48	Shared	8.3	11.06	No	No	No	No	8	5
159	8x53	I1x48	Shared	5.97	13.735	No	No	No	No	5	5
160	2x41	I1x50	Shared	5.71	3.57	No	No	No	No	7	6
161	2x44	I1x50	Shared	4.15	2.77	No	No	No	No	6	6
162	2x38	2x42	Shared	11.97	11.375	No	No	Yes	Yes	6	7
163	2x38	3x49	Shared	9.7	4.16	No	No	No	Yes	6	8
164	2x38	I2x57	Shared	6.2	3.72	No	No	Yes	Yes	6	6
165	2x39	3x49	Shared	7.23	9.395	No	No	No	Yes	8	8
166	2x42	3x45	Shared	10.55	9.375	Yes	Yes	No	No	7	6
167	2x42	4x42	Shared	4.35	4.35	Yes	Yes	No	No	7	7
168	2x42	4x45	Shared	7.49	6.245	Yes	Yes	No	No	7	6
169	2x45	3x42	Shared	16.92	13.895	No	No	Yes	Yes	9	7
170	2x45	4x46	Shared	7.45	7.45	No	No	No	No	9	7
171	2x45	4x50	Shared	6.78	4.52	No	No	Yes	Yes	9	9
172	2x46	7x49	Shared	4.12	8.24	No	No	No	Yes	9	9
173	2x49	3x38	Shared	6.52	6.52	No	Yes	No	No	8	7
174	2x50	7x49	Shared	6.73	6.735	No	Yes	No	Yes	9	9
175	2x53	3x32	Shared	10.32	15.475	No	Yes	Yes	Yes	7	7
176	2x53	7x42	Shared	4.98	5.595	No	Yes	No	Yes	7	8
177	2x53	7x46	Shared	5.59	7.68	No	Yes	No	No	7	8
178	2x59	E1x52	Shared	9.65	6.43	No	No	No	Yes	6	7
179	2x59	3x28	Shared	13.4	10.355	No	No	No	No	6	5
180	2x60	E1x50	Shared	6.56	3.75	Yes	Yes	Yes	Yes	7	9
181	2x60	Lig	Shared	28.37	22.76	Yes	Yes	Yes	Yes	7	0
182	2x62	E1x52	Shared	9.05	2.83	No	No	No	Yes	5	7
183	2x63	E1x50	Shared	9.65	9.165	Yes	Yes	Yes	Yes	4	9
184	2x63	E2.T177	Shared	4.99	4.37	Yes	Yes	No	No	4	2
185	2x63	Lig	Shared	7.03	7.62	Yes	Yes	Yes	Yes	4	0
186	E1x49	E1x51	Shared	7.83	3.92	No	No	No	No	3	3
187	E1x50	E1x52	Shared	14.03	19.54	Yes	Yes	No	Yes	9	7
188	3x25	E1x50	Shared	5.22	7.185	No	No	Yes	Yes	9	9
189	E1x50	E2x50	Shared	16.98	11.1	Yes	Yes	No	No	9	9
190	3x22	3x26	Shared	9.24	8.58	Yes	No	No	No	3	7
191	3x22	E2.R168	Shared	13.26	3.615	Yes	No	No	No	3	4
192	3x25	E2x50	Shared	7.28	7.28	No	No	No	No	9	9
193	3x29	4x65	Shared	14.13	8.635	No	No	No	No	5	5
194	3x29	Lig	Shared	8.74	7.785	No	No	Yes	Yes	5	0
195	3x32	3x33	Shared	8.25	5.67	Yes	Yes	No	No	7	5
196	3x32	Lig	Shared	13.91	8.93	Yes	Yes	Yes	Yes	7	0
197	3x33	3x37	Shared	5.36	5.36	No	No	Yes	Yes	5	7
198	3x33	4x61	Shared	19.33	11.775	No	No	No	No	5	4
199	3x34	4x57	Shared	4.64	5.415	No	No	No	No	5	7
200	3x36	3x37	Shared	9.65	8.575	No	Yes	Yes	Yes	7	7
201	3x36	6x48	Shared	10.02	6.015	No	Yes	Yes	Yes	7	9
202	3x37	3x41	Shared	4.29	3.215	Yes	Yes	Yes	Yes	7	5
203	3x38	4x50	Shared	8.65	10.505	No	No	Yes	Yes	7	9
204	3x40	6x44	Shared	16.92	4.235	Yes	No	Yes	Yes	7	9
205	3x41	4x49	Shared	3.89	4.54	Yes	Yes	No	No	5	6
206	3x41	4x52	Shared	3.93	1.965	Yes	Yes	No	No	5	4
207	3x42	4x49	Shared	6.49	9.08	Yes	Yes	No	No	7	6
208	3x42	4x50	Shared	8.02	8.02	Yes	Yes	Yes	Yes	7	9
209	3x44	5x50	Shared	5.08	5.93	Yes	No	Yes	No	7	9
210	3x44	5x53	Shared	4.61	4.61	Yes	No	No	No	7	6
211	3x45	4x49	Shared	4.42	4.42	No	No	No	No	6	6
212	3x49	I2x57	Shared	13.1	14.295	No	Yes	Yes	Yes	8	6
213	3x51	3x55	Shared	16.4	11.355	Yes	No	No	No	8	7
214	3x51	5x57	Shared	10.75	8.065	Yes	No	No	No	8	8
215	3x53	I2x57	Shared	6.91	3.455	No	No	Yes	Yes	8	6
216	3x55	3x56	Shared	8.3	6.225	No	No	No	No	7	6
217	I2x52	I2x56	Shared	4.16	2.775	No	No	No	No	5	4
218	4x38	4x40	Shared	4.71	3.14	No	No	No	No	6	4
219	4x64	E2.F182	Shared	10.72	5.895	Yes	Yes	Yes	Yes	5	5
220	4x64	5x35	Shared	15.03	13.53	Yes	Yes	Yes	Yes	5	3
221	E2.H181	E2.Q170	Shared	11.13	11.745	No	No	No	No	4	1
222	E2.Q170	Lig	Shared	5.86	9.04	No	No	Yes	Yes	1	0
223	E2.K171	E2.Y176	Shared	17.91	7.765	No	No	No	No	2	4
224	E2.E172	Lig	Shared	22.59	25.895	No	No	Yes	Yes	2	0
225	E2.T177	Lig	Shared	4.25	4.245	No	No	Yes	Yes	2	0
226	E2x51	Lig	Shared	18.05	9.4	No	No	Yes	Yes	3	0
227	E2x52	Lig	Shared	16.74	3.93	No	No	Yes	Yes	4	0
228	E2.F182	Lig	Shared	7.11	4.81	Yes	Yes	Yes	Yes	5	0
229	E2.Y184	Lig	Shared	22.88	20.515	No	No	Yes	Yes	1	0
230	5x31	E2.S185	Shared	5.78	3.61	No	No	No	No	3	3
231	5x31	5x35	Shared	4.38	8.215	No	No	Yes	Yes	3	3
232	5x32	5x36	Shared	8.36	7.76	No	No	No	No	3	4
233	5x32	Lig	Shared	23.77	20.025	No	No	Yes	Yes	3	0
234	5x34	5x35	Shared	18.04	12.03	No	No	Yes	Yes	1	3
235	5x35	5x38	Shared	6.01	8.02	Yes	Yes	No	No	3	3
236	5x37	6x60	Shared	7.25	5.44	No	No	No	No	3	5
237	5x40	6x59	Shared	14.13	12.56	No	No	No	Yes	5	5
238	5x40	Lig	Shared	7.84	3.92	No	No	Yes	Yes	5	0
239	5x44	6x52	Shared	4.43	3.695	No	No	No	No	5	8
240	5x44	6x56	Shared	7.45	2.235	No	No	No	No	5	5
241	5x47	6x52	Shared	5.49	10.98	No	No	No	No	8	8
242	5x51	6x45	Shared	8.53	2.435	No	No	Yes	No	6	5
243	5x52	5x56	Shared	4.28	0.715	No	No	No	No	4	4
244	5x58	5x61	Shared	4.84	3.63	Yes	Yes	Yes	No	9	8
245	6x30	I3.E227	Shared	9.3	7.56	No	No	No	No	7	3
246	6x43	7x52	Shared	4.61	3.84	No	No	No	No	6	8
247	6x44	6x48	Shared	14.47	12.54	Yes	Yes	Yes	Yes	9	9
248	6x44	7x45	Shared	4.36	5.99	Yes	Yes	Yes	No	9	9
249	6x47	7x40	Shared	4.87	5.48	No	Yes	No	No	8	8
250	6x47	7x45	Shared	10.18	9.615	No	Yes	Yes	No	8	9
251	6x48	7x41	Shared	11.26	5.63	Yes	Yes	No	No	9	8
252	6x48	7x45	Shared	6.35	15.34	Yes	Yes	Yes	No	9	9
253	6x51	6x55	Shared	11.72	15.825	Yes	No	No	Yes	7	6
254	6x51	7x37	Shared	4.99	8.74	Yes	No	No	Yes	7	7
255	6x51	7x38	Shared	6.73	13.47	Yes	No	No	No	7	6
256	6x54	7x37	Shared	6.35	4.76	No	No	No	Yes	5	7
257	6x55	Lig	Shared	4.42	5.17	No	Yes	Yes	Yes	6	0
258	6x57	6x64	Shared	7.31	5.48	No	No	No	No	4	1
259	6x58	7x30	Shared	5.49	6.18	No	No	No	No	4	5
260	6x58	7x34	Shared	5.61	4.91	No	No	No	Yes	4	5
261	6x59	6x60	Shared	11.67	7.785	No	Yes	No	No	5	5
262	6x61	Lig	Shared	11.28	5.05	No	No	Yes	Yes	4	0
263	6x62	E3.N267	Shared	13.15	1.315	No	No	Yes	No	3	3
264	E3.N267	Lig	Shared	7.17	2.7	Yes	No	Yes	Yes	3	0
265	7x23	7x25	Shared	4.47	2.235	No	No	No	No	4	1
266	7x23	7x26	Shared	8.94	2.98	No	No	No	No	4	1
267	7x26	7x29	Shared	3.95	1.975	No	No	No	No	1	2
268	7x27	Lig	Shared	5.28	3.96	No	No	Yes	Yes	3	0
269	7x31	Lig	Shared	11.22	8.03	No	No	Yes	Yes	4	0
270	7x34	Lig	Shared	7.88	5.135	No	Yes	Yes	Yes	5	0
271	7x35	Lig	Shared	17.85	7.825	No	No	Yes	Yes	3	0
272	8x55	8x59	Shared	5.32	0.665	No	No	No	No	4	3
273	Lig	Lig	Shared	529.84	402.115	Yes	Yes	Yes	Yes	0	0
274	2x48	2x52	Shared	3.77	5.02	No	No	No	No	6	7
275	3x36	5x43	Shared	3.77	4.395	No	Yes	No	No	7	5
276	1x58	I1x49	Shared	3.76	4.385	No	No	No	No	3	5
277	1x36	2x64	Shared	3.74	2.805	No	No	No	No	6	5
278	1x36	2x65	Shared	3.74	0.935	No	No	No	No	6	4
279	2x49	3x39	Shared	3.71	3.71	No	Yes	No	No	8	9
280	6x31	I3.E227	Shared	3.69	1.23	No	No	No	No	5	3
281	5x58	6x37	Shared	3.63	9.67	Yes	Yes	No	No	9	8
282	2x57	2x58	Shared	3.53	5.3	No	No	No	No	7	9
283	3x30	4x62	Shared	3.53	3.53	No	No	No	No	5	4
284	6x50	7x37	Shared	3.5	3.5	No	No	No	Yes	9	7
285	1x46	2x54	Shared	3.42	2.565	No	No	No	No	8	6
286	6x54	7x33	Shared	3.39	2.545	No	No	No	No	5	6
287	5x49	5x50	Shared	3.28	3.28	No	No	Yes	No	6	9
288	1x54	2x47	Shared	3.25	3.25	No	No	No	No	7	9
289	3x54	5x64	Shared	3.17	4.76	No	No	No	No	8	5
290	3x34	4x54	Shared	3.07	5.375	No	No	No	No	5	4
291	3x54	5x61	Shared	3.07	9.985	No	No	Yes	No	8	8
292	7x26	E3.L266	Shared	3	8.26	No	No	No	No	1	4
293	1x60	8x53	Shared	2.98	4.7	Yes	No	No	No	5	5
294	2x56	3x31	Shared	2.95	5.16	No	No	No	No	7	5
295	3x44	3x48	Shared	2.94	2.94	Yes	No	No	No	7	7
296	3x51	5x60	Shared	2.9	1.45	Yes	No	No	No	8	4
297	2x44	2x48	Shared	2.85	3.565	No	No	No	No	6	6
298	6x42	6x46	Shared	2.85	1.425	No	No	No	No	5	5
299	3x41	4x53	Shared	2.77	2.08	Yes	Yes	No	No	5	7
300	I2x53	I2x57	Shared	2.77	2.77	No	No	Yes	Yes	5	6
301	7x54	8x50	Shared	2.77	5.545	No	No	Yes	Yes	7	8
302	1x55	1x59	Shared	2.75	2.06	No	No	No	No	4	4
303	1x39	2x61	Shared	2.67	3.335	Yes	Yes	No	No	8	6
304	4x51	4x55	Shared	2.62	5.895	No	No	No	No	4	4
305	4x38	4x41	Shared	2.59	1.945	No	No	No	No	6	3
306	1x44	1x45	Shared	2.51	3.77	No	No	No	No	5	5
307	4x63	4x64	Shared	2.51	6.91	No	No	Yes	Yes	3	5
308	7x51	7x55	Shared	2.51	6.28	No	No	No	No	6	7
309	8x48	8x51	Shared	2.33	2.91	No	No	No	No	5	8
310	2x49	3x35	Shared	1.86	2.785	No	Yes	No	No	8	8
311	1x48	1x49	Shared	1.84	2.76	No	No	No	No	3	8
312	5x60	5x63	Shared	1.74	1.74	No	No	No	No	4	3
313	4x59	4x60	Shared	1.64	1.64	No	No	No	No	4	8
314	4x39	4x43	Shared	1.6	1.6	No	No	No	No	2	4
315	NT.E18	NT.P19	Shared	1.57	3.93	No	No	No	No	3	4
316	4x48	4x52	Shared	1.54	1.54	No	No	No	No	3	4
317	7x48	7x51	Shared	1.47	3.68	No	No	No	No	6	6
318	Lig	NT.Q21	Shared	1.44	6.89	Yes	Yes	No	No	0	1
319	5x41	5x45	Shared	1.43	2.14	No	No	No	No	4	5
320	1x47	2x55	Shared	1.22	1.22	No	Yes	No	No	6	5
321	3x56	I2x52	Shared	1.13	2.83	No	No	No	No	6	5
322	Lig	NT.E18	ccr5_on	0	7.09	Yes	Yes	No	No	0	3
323	1x24	7x28	ccr5_on	0	7.69	No	Yes	No	No	3	1
324	1x29	1x30	ccr5_on	0	6.175	No	No	No	No	2	2
325	1x31	7x35	ccr5_on	0	4.55	No	No	No	No	5	3
326	1x42	7x42	ccr5_on	0	5.325	No	No	No	Yes	7	8
327	1x43	1x47	ccr5_on	0	8.04	No	No	No	Yes	7	6
328	1x54	2x51	ccr5_on	0	4.28	No	No	No	No	7	7
329	1x56	8x54	ccr5_on	0	4.28	No	No	No	No	7	6
330	1x57	2x44	ccr5_on	0	6.23	No	No	No	No	7	6
331	1x59	8x57	ccr5_on	0	6.04	No	No	No	No	4	4
332	I1x48	I1x51	ccr5_on	0	4.31	No	No	No	No	5	7
333	I1x49	I1x50	ccr5_on	0	6.075	No	No	No	No	5	6
334	2x40	I1x51	ccr5_on	0	6.915	No	No	No	No	8	7
335	2x37	I2x57	ccr5_on	0	7.905	No	No	Yes	Yes	7	6
336	2x39	I2x57	ccr5_on	0	5.175	No	No	Yes	Yes	8	6
337	2x42	3x49	ccr5_on	0	4.6	Yes	Yes	No	Yes	7	8
338	2x46	2x50	ccr5_on	0	4.75	No	No	No	Yes	9	9
339	2x49	4x50	ccr5_on	0	3.71	No	Yes	Yes	Yes	8	9
340	2x50	7x46	ccr5_on	0	5.45	No	Yes	No	No	9	8
341	2x52	3x31	ccr5_on	0	6.7	No	No	No	No	7	5
342	2x53	3x36	ccr5_on	0	4.29	No	Yes	No	Yes	7	7
343	2x56	3x32	ccr5_on	0	4.995	No	No	Yes	Yes	7	7
344	2x57	7x42	ccr5_on	0	6.85	No	No	No	Yes	7	8
345	2x60	2x63	ccr5_on	0	5.785	Yes	Yes	Yes	Yes	7	4
346	2x60	3x28	ccr5_on	0	7.975	Yes	Yes	No	No	7	5
347	E1x49	E2.H175	ccr5_on	0	7.42	No	No	No	No	3	1
348	E1x50	E2.S169	ccr5_on	0	4.94	Yes	Yes	No	No	9	4
349	3x24	E1x52	ccr5_on	0	4.975	No	No	No	Yes	6	7
350	3x37	5x42	ccr5_on	0	8.065	Yes	Yes	No	No	7	3
351	3x38	3x42	ccr5_on	0	5.285	No	No	Yes	Yes	7	7
352	3x41	5x46	ccr5_on	0	6.09	Yes	Yes	No	No	5	4
353	3x43	7x53	ccr5_on	0	6.65	No	No	Yes	Yes	8	9
354	3x46	7x53	ccr5_on	0	4.105	No	No	Yes	Yes	9	9
355	3x47	5x54	ccr5_on	0	4.515	No	No	No	No	9	8
356	3x47	5x58	ccr5_on	0	6.24	No	No	Yes	Yes	9	9
357	3x50	5x58	ccr5_on	0	7.2	No	No	Yes	Yes	9	9
358	3x50	7x53	ccr5_on	0	4.63	No	No	Yes	Yes	9	9
359	I2x52	I2x55	ccr5_on	0	3.72	No	No	No	No	5	3
360	4x41	4x45	ccr5_on	0	7.78	No	No	No	No	3	6
361	4x64	E2.P183	ccr5_on	0	8.665	Yes	Yes	No	No	5	3
362	4x65	E2x52	ccr5_on	0	5.6	No	No	No	No	5	4
363	E2.Q170	E2.R168	ccr5_on	0	5.26	No	No	No	No	1	4
364	E2.H181	E2.R168	ccr5_on	0	13.545	No	No	No	No	4	4
365	E2.H181	Lig	ccr5_on	0	7.8	No	No	Yes	Yes	4	0
366	5x32	E2.F182	ccr5_on	0	7.22	No	No	Yes	Yes	3	5
367	5x35	E2.F182	ccr5_on	0	5.01	Yes	Yes	Yes	Yes	3	5
368	5x33	5x36	ccr5_on	0	4.07	No	No	No	No	2	4
369	5x36	6x59	ccr5_on	0	6.005	No	No	No	Yes	4	5
370	5x37	6x59	ccr5_on	0	4.385	No	No	No	Yes	3	5
371	5x39	Lig	ccr5_on	0	5.705	Yes	No	Yes	Yes	5	0
372	5x43	6x55	ccr5_on	0	4.995	No	No	No	Yes	5	6
373	5x50	6x44	ccr5_on	0	7.645	Yes	No	Yes	Yes	9	9
374	5x54	6x44	ccr5_on	0	4.19	No	No	Yes	Yes	8	9
375	5x58	6x40	ccr5_on	0	4.23	Yes	Yes	No	No	9	8
376	5x58	6x41	ccr5_on	0	5.985	Yes	Yes	Yes	No	9	8
377	5x62	6x34	ccr5_on	0	5.215	No	No	No	No	4	6
378	5x62	6x37	ccr5_on	0	7.14	No	No	No	No	4	8
379	6x29	I3.N226	ccr5_on	0	9.79	No	No	No	No	6	0
380	6x36	7x56	ccr5_on	0	7.45	No	No	No	No	8	7
381	6x45	6x49	ccr5_on	0	6.935	Yes	No	No	No	5	6
382	6x47	7x43	ccr5_on	0	7.785	No	Yes	No	No	8	5
383	6x54	7x34	ccr5_on	0	6.845	No	No	No	Yes	5	5
384	6x55	7x34	ccr5_on	0	4.945	No	Yes	No	Yes	6	5
385	6x57	7x30	ccr5_on	0	5.54	No	No	No	No	4	5
386	6x58	Lig	ccr5_on	0	6.71	No	No	Yes	Yes	4	0
387	6x60	6x63	ccr5_on	0	6.965	No	No	No	No	5	1
388	6x61	E3.L266	ccr5_on	0	3.99	No	No	No	No	4	4
389	6x61	7x30	ccr5_on	0	5.32	No	No	No	No	4	5
390	7x49	7x50	ccr5_on	0	7.33	No	Yes	No	No	9	9
391	7x49	7x53	ccr5_on	0	5.81	No	Yes	Yes	Yes	9	9
392	7x52	7x53	ccr5_on	0	4.235	No	No	Yes	Yes	8	9
393	7x55	8x50	ccr5_on	0	5.895	No	No	Yes	Yes	7	8
394	8x49	8x53	ccr5_on	0	7.765	No	No	No	No	6	5
395	1x30	7x32	ccr5_on	0	4.115	No	No	No	No	2	1
396	3x32	7x38	ccr5_on	0	4.49	Yes	Yes	No	No	7	6
397	E2.E172	E2.H175	ccr5_on	0	8.615	No	No	No	No	2	1
398	5x31	5x34	ccr5_on	0	4.685	No	No	No	No	3	1
399	6x28	I3.N226	ccr5_on	0	7.695	No	No	No	No	5	0
400	1x38	7x39	ccr5_on	0	3.685	No	No	No	No	6	6
401	1x47	2x51	ccr5_on	0	3.655	No	Yes	No	No	6	7
402	6x36	6x40	ccr5_on	0	3.565	No	No	No	No	8	8
403	2x54	7x42	ccr5_on	0	3.535	No	No	No	Yes	6	8
404	3x34	3x35	ccr5_on	0	3.53	No	No	No	No	5	8
405	1x57	2x43	ccr5_on	0	3.46	No	No	No	No	7	8
406	1x42	7x47	ccr5_on	0	3.42	No	No	No	No	7	8
407	5x461	6x52	ccr5_on	0	3.395	No	No	No	No	6	8
408	3x47	5x57	ccr5_on	0	3.38	No	No	No	No	9	8
409	8x48	8x52	ccr5_on	0	3.285	No	No	No	No	5	5
410	6x34	6x38	ccr5_on	0	3.275	No	No	No	No	6	5
411	7x47	7x48	ccr5_on	0	3.275	No	No	No	No	8	6
412	3x52	I2x53	ccr5_on	0	3.155	No	No	No	No	5	5
413	1x30	1x33	ccr5_on	0	3.135	No	No	No	No	2	3
414	6x46	6x47	ccr5_on	0	3.045	No	No	No	Yes	5	8
415	1x33	1x34	ccr5_on	0	3.035	No	No	No	No	3	6
416	8x48	8x50	ccr5_on	0	2.915	No	No	Yes	Yes	5	8
417	5x59	5x60	ccr5_on	0	2.785	No	No	No	No	3	4
418	5x47	5x51	ccr5_on	0	2.77	No	No	No	No	8	6
419	Lig	NT.T16	ccr5_on	0	2.585	Yes	Yes	No	No	0	2
420	1x45	7x51	ccr5_on	0	2.51	No	No	No	No	5	6
421	1x34	1x37	ccr5_on	0	2.465	No	No	No	No	6	5
422	E2.E172	E2.G173	ccr5_on	0	2.455	No	No	No	No	2	1
423	1x52	7x55	ccr5_on	0	2.435	No	No	No	No	6	7
424	4x56	5x42	ccr5_on	0	2.41	No	No	No	No	5	3
425	5x65	6x33	ccr5_on	0	2.365	No	No	No	No	8	8
426	7x24	7x28	ccr5_on	0	2.36	No	No	No	No	6	1
427	5x51	6x44	ccr5_on	0	2.34	No	No	Yes	Yes	6	9
428	4x57	4x62	ccr5_on	0	2.325	No	No	No	No	7	4
429	1x32	Lig	ccr5_on	0	2.315	No	No	Yes	Yes	4	0
430	5x45	5x48	ccr5_on	0	2.305	No	No	No	No	5	4
431	E2.K171	E2.S169	ccr5_on	0	2.295	No	No	No	No	2	4
432	5x55	6x41	ccr5_on	0	2.28	No	No	Yes	No	4	8
433	2x66	E1x49	ccr5_on	0	2.275	No	No	No	No	4	3
434	4x59	4x62	ccr5_on	0	2.14	No	No	No	No	4	4
435	5x45	5x46	ccr5_on	0	2.14	No	No	No	No	5	4
436	5x61	5x65	ccr5_on	0	2.14	Yes	No	No	No	8	8
437	6x32	6x35	ccr5_on	0	2.13	No	No	No	No	7	5
438	5x68	6x30	ccr5_on	0	2.09	No	No	No	No	0	7
439	5x49	5x52	ccr5_on	0	2.075	No	No	No	No	6	4
440	1x26	1x29	ccr5_on	0	1.98	No	No	No	No	1	2
441	3x21	E2.K171	ccr5_on	0	1.745	No	No	No	No	8	2
442	1x49	1x52	ccr5_on	0	1.71	No	No	No	No	8	6
443	2x41	4x43	ccr5_on	0	1.54	No	No	No	No	7	4
444	4x44	4x48	ccr5_on	0	1.535	No	No	No	No	1	3
445	8x47	8x51	ccr5_on	0	1.5	No	No	No	No	8	8
446	6x53	6x57	ccr5_on	0	1.425	No	No	No	No	6	4
447	E2.L174	Lig	ccr5_on	0	1.33	No	No	Yes	Yes	4	0
448	4x54	4x55	ccr5_on	0	1.31	No	No	No	No	4	4
449	5x64	5x67	ccr5_on	0	1.295	No	No	No	No	5	5
450	6x35	6x39	ccr5_on	0	1.29	No	No	No	No	5	5
451	8x57	CT.K314	ccr5_on	0	1.24	No	No	No	No	4	6
452	4x46	4x47	ccr5_on	0	0.81	No	No	No	No	7	4
453	5x68	6x29	ccr5_on	0	0.81	No	No	No	No	0	6
454	6x39	6x43	ccr5_on	0	0.795	No	No	No	No	5	6
455	7x36	7x37	ccr5_on	0	0.795	No	No	No	Yes	5	7
456	1x40	1x44	ccr5_on	0	0.775	No	No	No	No	3	5
457	8x55	8x56	ccr5_on	0	0.745	No	No	No	No	4	4
458	8x52	8x55	ccr5_on	0	0.685	No	No	No	No	5	4
459	6x30	6x34	ccr5_on	0	0.655	No	No	No	No	7	6

Orange: nodes, hubs and links specific of ccr5_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of ccr5_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	ccr5_off Avg Int. Strength	ccr5_on Avg Int. Strength	ccr5_off Num Of Links	ccr5_on Num Of Links	ConSurf
1	1x60	ccr5_off	7.38	3.7475	4	2	5
2	3x22	ccr5_off	7.8525	6.0975	4	2	3
3	3x40	ccr5_off	8.1325	4.235	4	1	7
4	3x44	ccr5_off	4.2625	4.49333	4	3	7
5	3x51	ccr5_off	7.85	6.95667	5	3	8
6	5x39	ccr5_off	7.3425	5.705	4	1	5
7	5x50	ccr5_off	4.588	5.61833	5	3	9
8	5x61	ccr5_off	3.955	5.25167	4	3	8
9	6x41	ccr5_off	5.2225	4.1325	4	2	8
10	6x45	ccr5_off	6.134	4.685	5	2	5
11	6x51	ccr5_off	7.5475	12.6783	4	3	7
12	E3.N267	ccr5_off	6.495	2.0075	4	2	3
13	7x45	ccr5_off	6.258	10.315	5	3	9
14	1x39	Shared	7.495	6.9425	6	4	8
15	2x42	Shared	8.59	7.189	4	5	7
16	2x60	Shared	11.014	10.0675	5	4	7
17	2x63	Shared	6.425	6.735	4	4	4
18	E1x50	Shared	9.20833	9.28	6	6	9
19	3x32	Shared	9.5675	7.912	4	5	7
20	3x37	Shared	5.60167	6.30375	6	4	7
21	3x41	Shared	3.72	3.578	4	5	5
22	3x42	Shared	8.8475	9.07	4	4	7
23	I2x57	Shared	7.245	6.22	4	6	6
24	4x50	Shared	8.1175	6.68875	4	4	9
25	4x64	Shared	8.8225	8.75	4	4	5
26	E2.F182	Shared	7.66	5.73375	4	4	5
27	5x35	Shared	10.314	9.361	5	5	3
28	5x58	Shared	5.595	6.15917	4	6	9
29	6x44	Shared	10.2275	6.15667	4	6	9
30	6x48	Shared	9.77	9.88125	5	4	9
31	7x53	Shared	4.935	5.086	4	5	9
32	8x50	Shared	4.602	6.059	5	5	8
33	Lig	Shared	42.4245	31.3599	33	34	0
34	1x24	ccr5_on	8.26667	5.30125	3	4	3
35	1x47	ccr5_on	4.34	4.6275	2	4	6
36	2x49	ccr5_on	4.03	4.18125	3	4	8
37	2x50	ccr5_on	9.425	6.92625	2	4	9
38	2x53	ccr5_on	6.96333	8.26	3	4	7
39	E1x52	ccr5_on	10.91	8.44375	3	4	7
40	3x36	ccr5_on	7.81333	5.81875	3	4	7
41	3x49	ccr5_on	10.01	8.1125	3	4	8
42	6x47	ccr5_on	8.36667	6.48125	3	4	8
43	6x55	ccr5_on	6.85333	7.73375	3	4	6
44	6x59	ccr5_on	12.9	7.68375	2	4	5
45	7x34	ccr5_on	6.745	5.45875	2	4	5
46	7x37	ccr5_on	4.94667	4.44875	3	4	7
47	7x42	ccr5_on	8	5.578	3	5	8
48	7x49	ccr5_on	5.31667	7.02875	3	4	9

Orange: nodes, hubs and links specific of ccr5_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of ccr5_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	ccr5_off Recurrence	ccr5_on Recurrence	ccr5_off Hub1?	ccr5_on Hub1?	ccr5_off Hub2?	ccr5_on Hub2?	ConSurf1	ConSurf2
1	7x35	7x39	ccr5_off	11.9013	0	No	No	No	No	3	6
2	1x39	7x42	ccr5_off	11.8336	6.79078	Yes	Yes	No	Yes	8	8
3	2x54	7x46	ccr5_off	11.5906	0	No	No	No	No	6	8
4	1x50	2x50	ccr5_off	14.1485	2.37226	No	No	No	Yes	9	9
5	7x45	7x49	ccr5_off	19.3242	0	Yes	No	No	Yes	9	9
6	6x48	7x45	ccr5_off	24.99	8.80955	Yes	Yes	Yes	No	9	9
7	6x48	6x51	ccr5_off	100	0	Yes	Yes	Yes	No	9	7
8	6x51	6x55	ccr5_off	49.6573	3.6173	Yes	No	No	Yes	7	6
9	6x51	7x38	ccr5_off	53.6457	2.34083	Yes	No	No	No	7	6
10	7x38	Lig	ccr5_off	47.8365	0	No	No	Yes	Yes	6	0
11	7x53	8x50	ccr5_off	28.2692	0	Yes	Yes	Yes	Yes	9	8
12	6x40	7x53	ccr5_off	35.979	0	No	No	Yes	Yes	8	9
13	3x43	6x40	ccr5_off	37.6165	0	No	No	No	No	8	8
14	3x40	3x43	ccr5_off	36.4929	0	Yes	No	No	No	7	8
15	3x40	6x44	ccr5_off	48.0317	1.73206	Yes	No	Yes	Yes	7	9
16	2x52	4x50	ccr5_off	16.842	0	No	No	Yes	Yes	7	9
17	1x56	8x50	ccr5_off	21.942	2.59613	No	No	Yes	Yes	7	8
18	1x56	8x53	ccr5_off	20.2526	0	No	No	No	No	7	5
19	1x60	8x53	ccr5_off	13.6146	6.79078	Yes	No	No	No	5	5
20	2x38	2x42	ccr5_off	23.1771	7.58415	No	No	Yes	Yes	6	7
21	2x38	I2x57	ccr5_off	19.7187	6.34303	No	No	Yes	Yes	6	6
22	2x59	E1x52	ccr5_off	10.4351	0.0549861	No	No	No	Yes	6	7
23	E1x50	E1x52	ccr5_off	18.5951	9.31621	Yes	Yes	No	Yes	9	7
24	3x25	E1x50	ccr5_off	20.7467	3.10278	No	No	Yes	Yes	9	9
25	3x22	E2.S169	ccr5_off	21.9898	0	Yes	No	No	No	3	4
26	3x25	E2.S169	ccr5_off	25.6275	0	No	No	No	No	9	4
27	3x22	3x26	ccr5_off	11.0288	3.20097	Yes	No	No	No	3	7
28	6x44	6x45	ccr5_off	50.3905	0	Yes	Yes	Yes	No	9	5
29	3x50	3x53	ccr5_off	16.4595	0	No	No	No	No	9	8
30	3x53	I2x57	ccr5_off	17.599	2.55292	No	No	Yes	Yes	8	6
31	3x51	5x61	ccr5_off	14.1167	0	Yes	No	Yes	No	8	8
32	5x54	5x58	ccr5_off	42.2344	0	No	No	Yes	Yes	8	9
33	5x54	6x45	ccr5_off	40.82	0	No	No	Yes	No	8	5
34	4x64	E2.F182	ccr5_off	11.3037	4.82699	Yes	Yes	Yes	Yes	5	5
35	6x29	6x33	ccr5_off	14.2721	0	No	No	No	No	6	8
36	3x50	6x33	ccr5_off	15.304	0	No	No	No	No	9	8
37	6x29	6x32	ccr5_off	13.1086	0	No	No	No	No	6	7
38	6x32	8x48	ccr5_off	10.7499	0	No	No	No	No	7	5
39	7x30	E3.L266	ccr5_off	26.0379	0	No	No	No	No	5	4
40	6x58	7x30	ccr5_off	29.2573	7.26209	No	No	No	No	4	5
41	6x58	6x61	ccr5_off	16.2961	0	No	No	No	No	4	4
42	6x58	7x34	ccr5_off	16.1766	1.37072	No	No	No	Yes	4	5
43	7x34	Lig	ccr5_off	17.6269	3.97471	No	Yes	Yes	Yes	5	0
44	7x26	E3.L266	ccr5_off	13.0807	6.39017	No	No	No	No	1	4
45	2x60	3x32	ccr5_off	11.4631	0	Yes	Yes	Yes	Yes	7	7
46	2x60	Lig	Shared	24.4322	19.7439	Yes	Yes	Yes	Yes	7	0
47	2x53	7x46	Shared	13.4951	31.833	No	Yes	No	No	7	8
48	2x53	3x32	Shared	18.2684	75.9711	No	Yes	Yes	Yes	7	7
49	3x32	Lig	Shared	31.3611	100	Yes	Yes	Yes	Yes	7	0
50	2x50	7x49	Shared	15.8817	26.8725	No	Yes	No	Yes	9	9
51	6x55	Lig	Shared	47.8245	28.6831	No	Yes	Yes	Yes	6	0
52	6x44	6x48	Shared	95.0116	75.4016	Yes	Yes	Yes	Yes	9	9
53	2x44	2x48	Shared	14.531	24.4963	No	No	No	No	6	6
54	2x48	2x52	Shared	15.6905	25.7217	No	No	No	No	6	7
55	3x42	4x50	Shared	22.3285	15.62	Yes	Yes	Yes	Yes	7	9
56	3x42	4x49	Shared	25.6793	35.9334	Yes	Yes	No	No	7	6
57	3x41	4x49	Shared	53.327	56.7535	Yes	Yes	No	No	5	6
58	3x37	3x41	Shared	56.6579	64.6715	Yes	Yes	Yes	Yes	7	5
59	3x33	3x37	Shared	46.6053	35.7606	No	No	Yes	Yes	5	7
60	3x32	3x33	Shared	42.4616	36.3497	Yes	Yes	No	No	7	5
61	2x42	3x45	Shared	30.6518	23.4476	Yes	Yes	No	No	7	6
62	3x45	4x49	Shared	31.6878	24.6102	No	No	No	No	6	6
63	2x60	E1x50	Shared	26.1774	15.3411	Yes	Yes	Yes	Yes	7	9
64	2x63	E1x50	Shared	18.0333	15.3607	Yes	Yes	Yes	Yes	4	9
65	2x63	Lig	Shared	28.9266	16.6372	Yes	Yes	Yes	Yes	4	0
66	3x36	3x37	Shared	33.7158	32.3789	No	Yes	Yes	Yes	7	7
67	3x36	6x48	Shared	35.2219	86.6737	No	Yes	Yes	Yes	7	9
68	5x58	5x61	Shared	32.6998	14.3946	Yes	Yes	Yes	No	9	8
69	E2.F182	Lig	Shared	14.1446	14.0254	Yes	Yes	Yes	Yes	5	0
70	3x36	5x43	Shared	10.4431	32.0804	No	Yes	No	No	7	5
71	6x61	Lig	Shared	17.591	15.3843	No	No	Yes	Yes	4	0
72	1x24	Lig	ccr5_on	4.85298	24.7634	No	Yes	Yes	Yes	3	0
73	1x24	1x27	ccr5_on	3.40665	18.9427	No	Yes	No	No	3	1
74	1x27	7x32	ccr5_on	1.70532	17.407	No	No	No	No	1	1
75	1x30	7x32	ccr5_on	0	15.8635	No	No	No	No	2	1
76	2x53	7x42	ccr5_on	5.23149	49.5307	No	Yes	No	Yes	7	8
77	1x42	7x42	ccr5_on	0	30.5526	No	No	No	Yes	7	8
78	2x57	2x58	ccr5_on	3.66165	10.6398	No	No	No	No	7	9
79	2x57	7x42	ccr5_on	0	11.9516	No	No	No	Yes	7	8
80	7x48	7x51	ccr5_on	3.58196	26.9471	No	No	No	No	6	6
81	7x47	7x48	ccr5_on	0	28.1568	No	No	No	No	8	6
82	1x42	7x47	ccr5_on	0	29.3586	No	No	No	No	7	8
83	2x50	7x46	ccr5_on	0	30.8904	No	Yes	No	No	9	8
84	7x55	8x50	ccr5_on	0	15.8321	No	No	Yes	Yes	7	8
85	7x51	7x55	ccr5_on	1.79297	20.7729	No	No	No	No	6	7
86	2x52	3x31	ccr5_on	0	26.9392	No	No	No	No	7	5
87	2x56	3x31	ccr5_on	1.57383	28.1489	No	No	No	No	7	5
88	2x56	3x32	ccr5_on	0	29.3508	No	No	Yes	Yes	7	7
89	1x58	I1x49	ccr5_on	2.49821	14.4103	No	No	No	No	3	5
90	I1x49	I1x50	ccr5_on	0	15.6985	No	No	No	No	5	6
91	2x44	I1x50	ccr5_on	4.96852	20.7729	No	No	No	No	6	6
92	1x58	1x59	ccr5_on	2.49821	13.1142	No	No	No	No	3	4
93	1x59	8x57	ccr5_on	0	10.4906	No	No	No	No	4	4
94	2x49	3x38	ccr5_on	2.49024	14.4653	No	Yes	No	No	8	7
95	3x38	3x42	ccr5_on	0	15.6318	No	No	Yes	Yes	7	7
96	2x49	4x50	ccr5_on	0	14.6067	No	Yes	Yes	Yes	8	9
97	2x53	3x36	ccr5_on	0	57.6922	No	Yes	No	Yes	7	7
98	5x43	6x55	ccr5_on	0	31.8369	No	No	No	Yes	5	6
99	E1x50	E2.S169	ccr5_on	0	12.3915	Yes	Yes	No	No	9	4
100	3x34	3x35	ccr5_on	0	21.9119	No	No	No	No	5	8
101	2x49	3x35	ccr5_on	0.00398438	24.3078	No	Yes	No	No	8	8
102	3x34	4x57	ccr5_on	2.49024	12.2501	No	No	No	No	5	7
103	7x49	7x53	ccr5_on	0	25.5017	No	Yes	Yes	Yes	9	9
104	5x50	6x44	ccr5_on	0	11.983	Yes	No	Yes	Yes	9	9
105	3x47	5x54	ccr5_on	0	53.3875	No	No	No	No	9	8
106	5x54	6x44	ccr5_on	0	54.5265	No	No	Yes	Yes	8	9
107	3x47	5x58	ccr5_on	0	38.1368	No	No	Yes	Yes	9	9
108	3x51	5x57	ccr5_on	1.78899	15.3018	Yes	No	No	No	8	8
109	3x47	5x57	ccr5_on	0	16.9632	No	No	No	No	9	8
110	3x50	5x58	ccr5_on	0	18.9584	No	No	Yes	Yes	9	9
111	3x50	7x53	ccr5_on	0	19.3865	No	No	Yes	Yes	9	9
112	5x51	6x44	ccr5_on	0	13.664	No	No	Yes	Yes	6	9
113	5x58	6x37	ccr5_on	3.37876	26.1773	Yes	Yes	No	No	9	8
114	5x62	6x37	ccr5_on	0	23.8365	No	No	No	No	4	8
115	5x62	6x34	ccr5_on	0	21.4878	No	No	No	No	4	6
116	6x30	6x34	ccr5_on	0	16.7668	No	No	No	No	7	6
117	6x57	7x30	ccr5_on	0	10.1057	No	No	No	No	4	5

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
Lig	NT.S17	Shared	11.04	3.26	1	1	0	1
Lig	NT.P19	Shared	22.31	13.22	1	1	0	1
7x24	NT.C20	Shared	7.28	7.28	0	0	2	1
7x28	NT.C20	ccr5_off	4.72	0	0	0	2	1
Lig	NT.C20	ccr5_off	4.19	0	1	1	0	1
1x24	1x27	Shared	10.62	3.795	1	1	1	2
1x24	1x28	Shared	4.31	4.31	1	1	1	1
1x24	Lig	Shared	9.87	5.41	1	1	1	0
1x28	E2.H175	ccr5_off	5.24	0	1	1	1	2
1x28	Lig	Shared	4.23	12.945	1	1	1	0
1x31	Lig	ccr5_off	4.73	0	0	0	1	0
2x53	3x32	Shared	10.32	15.475	0	0	2	1
2x53	7x42	Shared	4.98	5.595	0	0	2	2
2x56	2x60	ccr5_off	9.7	0	0	0	2	1
2x60	E1x50	Shared	6.56	3.75	1	1	1	2
2x60	3x32	ccr5_off	5.79	0	1	1	1	1
2x60	7x42	ccr5_off	4.65	0	1	1	1	2
2x60	Lig	Shared	28.37	22.76	1	1	1	0
2x63	E1x50	Shared	9.65	9.165	1	1	1	2
2x63	E2.T177	Shared	4.99	4.37	1	1	1	1
2x63	E2x50	ccr5_off	4.03	0	1	1	1	2
2x63	Lig	Shared	7.03	7.62	1	1	1	0
E1x50	E2x50	Shared	16.98	11.1	1	1	2	2
3x29	4x65	Shared	14.13	8.635	1	1	1	1
3x29	Lig	Shared	8.74	7.785	1	1	1	0
3x32	3x33	Shared	8.25	5.67	1	1	1	2
3x32	Lig	Shared	13.91	8.93	1	1	1	0
3x33	4x61	Shared	19.33	11.775	0	0	2	2
4x60	5x39	ccr5_off	6.32	0	0	0	2	1
4x61	5x39	ccr5_off	9.24	0	6	0	2	1
4x61	5x42	ccr5_off	5.6	0	6	0	2	2
4x64	E2.F182	Shared	10.72	5.895	0	1	2	1
4x64	5x35	Shared	15.03	13.53	0	1	2	2
4x64	5x39	ccr5_off	7.03	0	0	1	2	1
4x65	Lig	ccr5_off	6.99	0	1	0	1	0
E2.E172	E2.Q170	ccr5_off	12.74	0	1	1	1	1
E2.H181	E2.Q170	Shared	11.13	11.745	0	1	1	1
E2.Q170	Lig	Shared	5.86	9.04	1	1	1	0
E2.K171	E2.Y176	Shared	17.91	7.765	1	0	1	2
E2.K171	Lig	ccr5_off	10.8	0	1	0	1	0
E2.E172	E2.T177	ccr5_off	16.93	0	1	1	1	1
E2.E172	Lig	Shared	22.59	25.895	1	1	1	0
E2.G173	Lig	ccr5_off	5.12	0	0	0	1	0
E2.T177	Lig	Shared	4.25	4.245	1	1	1	0
E2.H181	E2x51	ccr5_off	5.58	0	0	1	1	1
E2x51	Lig	Shared	18.05	9.4	1	0	1	0
E2.F182	E2x52	ccr5_off	6.61	0	1	1	1	1
E2x52	Lig	Shared	16.74	3.93	1	1	1	0
5x36	E2.F182	ccr5_off	6.2	0	0	0	2	1
E2.F182	Lig	Shared	7.11	4.81	1	1	1	0
E2.S185	E2.Y184	ccr5_off	6.36	0	0	0	2	1
E2.Y184	Lig	Shared	22.88	20.515	1	0	1	0
5x32	5x36	Shared	8.36	7.76	1	1	1	2
5x32	Lig	Shared	23.77	20.025	1	1	1	0
5x39	5x42	ccr5_off	6.78	0	6	0	1	2
5x40	6x55	ccr5_off	4.42	0	1	1	1	1
5x40	6x59	Shared	14.13	12.56	1	1	1	2
5x40	Lig	Shared	7.84	3.92	1	1	1	0
6x51	6x55	Shared	11.72	15.825	0	0	2	1
6x51	7x38	Shared	6.73	13.47	0	0	2	1
6x55	Lig	Shared	4.42	5.17	1	1	1	0
6x58	6x61	ccr5_off	6.6	0	0	1	1	1
6x58	7x30	Shared	5.49	6.18	0	1	1	2
6x58	7x34	Shared	5.61	4.91	0	1	1	1
6x61	E3.N267	ccr5_off	3.96	0	1	1	1	1
6x61	Lig	Shared	11.28	5.05	1	1	1	0
6x62	E3.N267	Shared	13.15	1.315	0	0	2	1
7x30	E3.L266	ccr5_off	5.54	0	0	0	2	2
E3.N267	Lig	Shared	7.17	2.7	1	1	1	0
7x27	Lig	Shared	5.28	3.96	0	0	1	0
7x31	Lig	Shared	11.22	8.03	0	0	1	0
7x34	Lig	Shared	7.88	5.135	1	1	1	0
7x35	7x38	ccr5_off	11.47	0	1	1	1	1
7x35	7x39	ccr5_off	5.67	0	1	1	1	2
7x35	Lig	Shared	17.85	7.825	1	1	1	0
7x38	Lig	ccr5_off	7.37	0	1	0	1	0
3x21	E1x50	ccr5_off	2.81	0	0	0	2	2
6x65	E3.N267	ccr5_off	1.7	0	0	0	2	1
NT.S17	NT.T16	ccr5_off	1.6	0	1	0	1	1
NT.E18	NT.P19	Shared	1.57	3.93	0	1	1	1
Lig	NT.Q21	Shared	1.44	6.89	1	1	0	1
E2.H175	E2.L174	ccr5_off	1.29	0	0	0	2	1
Lig	NT.E18	ccr5_on	0	7.09	1	1	0	1
1x24	7x28	ccr5_on	0	7.69	1	1	1	2
1x31	7x35	ccr5_on	0	4.55	0	0	1	1
2x56	3x32	ccr5_on	0	4.995	0	0	2	1
2x60	2x63	ccr5_on	0	5.785	1	1	1	1
2x60	3x28	ccr5_on	0	7.975	1	1	1	2
E1x50	E2.S169	ccr5_on	0	4.94	1	1	2	2
4x65	E2x52	ccr5_on	0	5.6	1	0	1	1
E2.Q170	E2.R168	ccr5_on	0	5.26	1	1	1	2
E2.H181	E2.R168	ccr5_on	0	13.545	0	1	1	2
E2.H181	Lig	ccr5_on	0	7.8	0	1	1	0
5x32	E2.F182	ccr5_on	0	7.22	1	1	1	1
5x35	E2.F182	ccr5_on	0	5.01	8	1	2	1
5x36	6x59	ccr5_on	0	6.005	0	0	2	2
5x39	Lig	ccr5_on	0	5.705	6	0	1	0
5x43	6x55	ccr5_on	0	4.995	0	0	2	1
6x54	7x34	ccr5_on	0	6.845	0	0	2	1
6x55	7x34	ccr5_on	0	4.945	1	1	1	1
6x58	Lig	ccr5_on	0	6.71	0	1	1	0
6x61	E3.L266	ccr5_on	0	3.99	1	1	1	2
6x61	7x30	ccr5_on	0	5.32	1	1	1	2
3x32	7x38	ccr5_on	0	4.49	1	1	1	1
E2.E172	E2.H175	ccr5_on	0	8.615	1	1	1	2
Lig	NT.T16	ccr5_on	0	2.585	1	1	0	1
E2.E172	E2.G173	ccr5_on	0	2.455	1	1	1	1
7x24	7x28	ccr5_on	0	2.36	0	0	2	2
1x32	Lig	ccr5_on	0	2.315	0	0	1	0
E2.K171	E2.S169	ccr5_on	0	2.295	1	0	1	2
3x21	E2.K171	ccr5_on	0	1.745	0	0	2	1
E2.L174	Lig	ccr5_on	0	1.33	0	0	1	0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	ccr5_off	5UIW-CCR5-5P7-CCL5
	ccr5_on	7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2

Network Difference
Value	ccr5_off	ccr5_on
I_min	3.89	3.705
Number of Linked Nodes	287	291
Number of Specific Nodes	7 (2.44%)	11 (3.78%)
Number of Shared Nodes	280 (97.56%)	280 (96.22%)
Number of Links	321	324
Number of Specific Links	135 (42.06%)	138 (42.59%)
Number of Shared Links	186 (57.94%)	186 (57.41%)
Number of Hubs	33	35
Number of Specific Hubs	13 (39.39%)	15 (42.86%)
Number of Shared Hubs	20 (60.61%)	20 (57.14%)
Average % Shared Neighbours (Jaccard)	42.85
Average % Shared Neighbours (Otsuka)	52.95
Average % Shared Neighbours (Overlap Coefficient)	62.67
Average % Shared Cliques (k3-6)	78.57
Graphlets Similarity	0.615453

Paths Difference
Value	ccr5_off	ccr5_on
Number Of Nodes in MetaPath	69	69
Specific Nodes in MetaPath	32 (46.38%)	32 (46.38%)
Shared Nodes in MetaPath	280 (97.56%)	280 (97.56%)
Number Of Links MetaPath	71	72
Specific Links in MetaPath	45 (63.38%)	46 (63.89%)
Shared Links in MetaPath	186 (57.94%)	186 (57.94%)
Number of Shortest Paths	60961	63423
Length Of Smallest Path	3	3
Average Path Length	12.0555	12.2787
Length of Longest Path	32	30
Minimum Path Strength	1.45	0.675
Average Path Strength	7.5314	6.41237
Maximum Path Strength	20.6133	19.09
Minimum Path Correlation	0.7	0.7
Average Path Correlation	0.942564	0.938226
Maximum Path Correlation	0.99	0.99
Minimum % Of Corr. Nodes	3.84615	4.54545
Average % Of Corr. Nodes	58.602	58.2645
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	44.5726	45.03
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

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