Orange: nodes, hubs and links specific of ccr5_on_gp network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of ccr5_off network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.


Index Hub Owner ccr5_on_gp Avg Int. Strength ccr5_off Avg Int. Strength ccr5_on_gp Num Of Links ccr5_off Num Of Links ConSurf
1G.S1.02 ccr5_on_gp5.2680505
2G.S1.06 ccr5_on_gp4.71250408
3G.H1.01 ccr5_on_gp5.740830609
4G.H1.03 ccr5_on_gp4.341250409
5G.H1.07 ccr5_on_gp4.631250409
6G.S2.01 ccr5_on_gp4.666250409
7G.S2.08 ccr5_on_gp8.25250405
8G.S3.01 ccr5_on_gp5.280404
9G.S3.03 ccr5_on_gp7.45750607
10G.S3.06 ccr5_on_gp7.818330605
11G.S3.07 ccr5_on_gp4.87250609
12G.H2.04 ccr5_on_gp5.70250409
13G.H2.06 ccr5_on_gp6.5480509
14G.H2.07 ccr5_on_gp5.30750609
15G.H2.09 ccr5_on_gp7.783750408
16G.h2s4.01 ccr5_on_gp8.376250409
17G.S4.02 ccr5_on_gp5.701250408
18G.S4.04 ccr5_on_gp7.421250409
19G.s4h3.02 ccr5_on_gp5.10750409
20G.s4h3.03 ccr5_on_gp4.690408
21G.s4h3.04 ccr5_on_gp6.401430708
22G.H3.09 ccr5_on_gp6.201670609
23G.H3.17 ccr5_on_gp9.5250405
24G.H3.18 ccr5_on_gp5.668750409
25G.S5.02 ccr5_on_gp4.0050406
26G.S5.03 ccr5_on_gp3.8950508
27G.S5.04 ccr5_on_gp4.21250409
28G.S5.05 ccr5_on_gp4.218750809
29G.S5.07 ccr5_on_gp4.591250409
30G.HG.04 ccr5_on_gp7.1030509
31G.HG.07 ccr5_on_gp6.318750409
32G.HG.08 ccr5_on_gp4.4670506
33G.HG.13 ccr5_on_gp3.57750407
34G.HG.15 ccr5_on_gp4.11750407
35G.hgh4.01 ccr5_on_gp3.22750406
36G.hgh4.02 ccr5_on_gp5.190830607
37G.hgh4.05 ccr5_on_gp5.2710507
38G.H4.03 ccr5_on_gp8.181250404
39G.H4.10 ccr5_on_gp7.7450506
40G.S6.02 ccr5_on_gp6.6050707
41G.s6h5.01 ccr5_on_gp7.516250409
42G.s6h5.05 ccr5_on_gp3.96750409
43G.H5.03 ccr5_on_gp4.628750408
44G.H5.05 ccr5_on_gp6.060405
45G.H5.06 ccr5_on_gp7.73750403
46G.H5.08 ccr5_on_gp5.6150608
47G.H5.20 ccr5_on_gp6.351250409
48G.H5.25 ccr5_on_gp4.28250407
49G.H5.26 ccr5_on_gp7.2710505
50b.lh12x2 ccr5_on_gp3.4880508
51b.h2x1 ccr5_on_gp3.46250405
52b.lhb1x3 ccr5_on_gp3.94250402
53b.lhb1x6 ccr5_on_gp4.293750403
54b.l1x3 ccr5_on_gp7.327140709
55b.b2x1 ccr5_on_gp10.0730508
56b.b2x3 ccr5_on_gp4.736250406
57b.b2x5 ccr5_on_gp6.5450607
58b.b3x3 ccr5_on_gp3.871250408
59b.l3x2 ccr5_on_gp6.83250409
60b.b4x5 ccr5_on_gp3.9450407
61b.b4x6 ccr5_on_gp8.451880809
62b.l4x2 ccr5_on_gp7.3310504
63b.b5x2 ccr5_on_gp5.731250407
64b.b5x3 ccr5_on_gp7.7130509
65b.b5x5 ccr5_on_gp4.680405
66b.l5x1 ccr5_on_gp3.773750408
67b.l5x5 ccr5_on_gp8.361430709
68b.b6x5 ccr5_on_gp3.924290706
69b.b7x1 ccr5_on_gp7.456250404
70b.b7x4 ccr5_on_gp4.580408
71b.l7x2 ccr5_on_gp4.053750409
72b.l7x4 ccr5_on_gp4.90250409
73b.l7x5 ccr5_on_gp4.360406
74b.b8x4 ccr5_on_gp5.7560506
75b.l9x3 ccr5_on_gp7.076670609
76b.l9x6 ccr5_on_gp5.810708
77b.b10x5 ccr5_on_gp5.2460509
78b.l10x1 ccr5_on_gp5.1980503
79b.b11x1 ccr5_on_gp6.831250405
80b.b11x4 ccr5_on_gp5.00750409
81b.l11x2 ccr5_on_gp7.50250409
82b.b12x5 ccr5_on_gp4.628750406
83b.b12x6 ccr5_on_gp8.689170608
84b.l12x1 ccr5_on_gp2.651250406
85b.b13x7 ccr5_on_gp7.240607
86b.l13x3 ccr5_on_gp6.869170609
87b.l13x6 ccr5_on_gp6.2890509
88b.b14x5 ccr5_on_gp4.103750405
89b.b15x2 ccr5_on_gp6.4440506
90b.b15x3 ccr5_on_gp4.62750409
91b.l15x1 ccr5_on_gp4.948750407
92b.l15x2 ccr5_on_gp4.553750409
93b.b16x4 ccr5_on_gp8.2450506
94b.b16x5 ccr5_on_gp5.1110505
95b.b16x6 ccr5_on_gp8.530830608
96b.b17x5 ccr5_on_gp7.8450407
97b.l17x3 ccr5_on_gp8.6670509
98b.l17x6 ccr5_on_gp6.3650509
99b.b18x3 ccr5_on_gp5.601250408
100b.b18x5 ccr5_on_gp5.071250405
101b.l18x1 ccr5_on_gp6.053570706
102b.b19x2 ccr5_on_gp8.6120506
103b.l19x1 ccr5_on_gp6.59750409
104b.l19x2 ccr5_on_gp4.92750409
105b.b20x2 ccr5_on_gp4.95750406
106b.b20x4 ccr5_on_gp10.7020508
107b.b20x6 ccr5_on_gp7.630506
108b.b20x7 ccr5_on_gp4.3630509
109b.l20x2 ccr5_on_gp5.127140709
110b.b21x2 ccr5_on_gp3.9390506
111b.b21x5 ccr5_on_gp4.64750404
112b.b21x7 ccr5_on_gp6.426250405
113b.l21x5 ccr5_on_gp4.533750404
114b.b22x5 ccr5_on_gp6.5620507
115b.l22x5 ccr5_on_gp5.543330609
116b.b23x2 ccr5_on_gp5.461250406
117b.b23x6 ccr5_on_gp7.184290707
118b.l23x2 ccr5_on_gp6.46750408
119b.b24x4 ccr5_on_gp7.59250406
120b.b24x6 ccr5_on_gp9.071250408
121b.b24x7 ccr5_on_gp7.88750409
122b.l24x2 ccr5_on_gp4.4330506
123b.l25x3 ccr5_on_gp9.150509
124b.l26x1 ccr5_on_gp7.0350407
125b.l27x1 ccr5_on_gp13.17420609
126b.l27x2 ccr5_on_gp8.98250409
127b.b28x3 ccr5_on_gp4.908750407
128b.b28x4 ccr5_on_gp8.411250406
129b.b28x6 ccr5_on_gp9.0720509
130b.b28x7 ccr5_on_gp5.60250409
1311x24 ccr5_on_gp5.3012511.83433
1321x47 ccr5_on_gp4.62754.34426
133I1x48 ccr5_on_gp8.173757.135425
1342x38 ccr5_on_gp5.1719.29536
1352x49 ccr5_on_gp4.181254.03438
1362x50 ccr5_on_gp6.1859.425529
1372x53 ccr5_on_gp8.266.96333437
1382x56 ccr5_on_gp4.376.325427
139E1x52 ccr5_on_gp8.4437510.91437
1403x29 ccr5_on_gp5.6737511.435425
1413x33 ccr5_on_gp5.89610.98535
1423x36 ccr5_on_gp5.2837.81333537
1433x45 ccr5_on_gp5.098757.485426
1443x49 ccr5_on_gp8.112510.01438
1453x50 ccr5_on_gp6.086259.815429
146E2.R168 ccr5_on_gp6.477513.26414
1476x47 ccr5_on_gp6.481258.36667438
1486x55 ccr5_on_gp6.786.86536
1496x59 ccr5_on_gp7.6837512.9425
1506x61 ccr5_on_gp4.49257.28434
1517x34 ccr5_on_gp5.458756.745425
1527x37 ccr5_on_gp4.448754.94667437
1537x42 ccr5_on_gp5.5788538
1547x49 ccr5_on_gp6.3315.31667539
1557x55 ccr5_on_gp4.5652.51417
1568x48 ccr5_on_gp3.096254.65425
1578x49 ccr5_on_gp4.61.64416
158g.h2x2 ccr5_on_gp3.653750405
159g.h2x12 ccr5_on_gp2.633750408
160g.h2x15 ccr5_on_gp6.081250409
161g.l3x4 ccr5_on_gp4.111250409
162g.ctx9 ccr5_on_gp3.0980507
1631x39 Shared6.1857.495568
1642x42 Shared6.479178.59647
1652x60 Shared7.1728611.014757
1662x63 Shared6.7356.446454
167E1x50 Shared9.289.20833669
1683x32 Shared7.9129.5675547
1693x37 Shared5.6525.60167567
1703x41 Shared3.5783.72545
1713x42 Shared7.205838.8475647
1723x51 Shared6.0357.85458
173I2x57 Shared5.577147.245746
1744x50 Shared6.688758.1175449
1754x64 Shared8.758.8225445
176E2.F182 Shared5.3937.665545
1775x35 Shared9.36110.314553
1785x58 Shared6.159175.595649
1796x44 Shared6.1566710.2275649
1806x48 Shared8.6099.77559
1816x51 Shared10.30137.5475447
1827x53 Shared5.0864.935549
1838x50 Shared6.0594.602558
184Lig Shared28.412140.726138330
1851x60 ccr5_off3.74754.6725245
1863x22 ccr5_off6.09757.8525243
1873x40 ccr5_off3.631678.1325347
1883x44 ccr5_off4.493334.2625347
189E2.T177 ccr5_off4.30758.255242
1905x39 ccr5_off4.217.3425345
1915x50 ccr5_off5.618334.588359
1925x61 ccr5_off6.80753.955248
1936x41 ccr5_off3.958335.2225348
1946x45 ccr5_off4.6856.134255
195E3.N267 ccr5_off2.00756.495243
1967x45 ccr5_off10.3156.258359
1977x48 ccr5_off3.47754.94246
   
Orange: nodes, hubs and links specific of ccr5_on_gp network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of ccr5_off network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Owner ccr5_on_gp Recurrence ccr5_off Recurrence ccr5_on_gp Hub1? ccr5_off Hub1? ccr5_on_gp Hub2? ccr5_off Hub2? ConSurf1 ConSurf2
1G.HN.40 b.b5x2 ccr5_on_gp10.97080NoNoYesNo77
2G.HN.40 b.b5x3 ccr5_on_gp10.66760NoNoYesNo79
3G.HN.43 b.b5x3 ccr5_on_gp21.33810NoNoYesNo99
4G.HN.39 G.HN.43 ccr5_on_gp22.5520NoNoNoNo59
5G.HN.39 b.b5x5 ccr5_on_gp23.76640NoNoYesNo55
6b.b4x4 b.b5x3 ccr5_on_gp11.8780NoNoYesNo89
7b.b4x4 b.l1x3 ccr5_on_gp10.96450NoNoYesNo89
8b.l1x3 b.l3x2 ccr5_on_gp14.62890YesNoYesNo99
9b.b4x2 b.l3x2 ccr5_on_gp10.9720NoNoYesNo89
10b.b4x6 b.b5x3 ccr5_on_gp17.38360YesNoYesNo99
11b.b4x6 b.l1x3 ccr5_on_gp10.97660YesNoYesNo99
12b.b5x2 b.l4x3 ccr5_on_gp15.50980YesNoNoNo76
13b.b4x7 b.l4x3 ccr5_on_gp15.81420NoNoNoNo86
14b.b3x1 b.b4x7 ccr5_on_gp29.09340NoNoNoNo58
15b.b3x1 b.b6x5 ccr5_on_gp29.39680NoNoYesNo56
16b.b2x4 b.b6x5 ccr5_on_gp67.97990NoNoYesNo66
17b.b10x4 b.b2x4 ccr5_on_gp68.25290NoNoNoNo66
18b.b10x4 b.b14x5 ccr5_on_gp68.55280NoNoYesNo65
19b.b14x5 b.l10x1 ccr5_on_gp54.26090YesNoYesNo53
20b.b11x1 b.l10x1 ccr5_on_gp27.72980YesNoYesNo53
21b.b11x1 b.l16x2 ccr5_on_gp34.19020YesNoNoNo59
22b.l14x5 b.l16x2 ccr5_on_gp68.36270NoNoNoNo59
23b.l14x3 b.l14x5 ccr5_on_gp68.46490NoNoNoNo55
24b.l14x1 b.l14x3 ccr5_on_gp68.56740NoNoNoNo45
25b.b18x5 b.l14x1 ccr5_on_gp68.67850YesNoNoNo54
26b.b15x2 b.b18x5 ccr5_on_gp69.00010YesNoYesNo65
27b.b15x2 b.b18x3 ccr5_on_gp34.99320YesNoYesNo68
28b.b18x3 b.b19x4 ccr5_on_gp35.12820YesNoNoNo88
29b.b19x4 b.l17x3 ccr5_on_gp35.19210NoNoYesNo89
30b.b19x6 b.l17x3 ccr5_on_gp35.32890NoNoYesNo99
31b.b19x6 b.l19x2 ccr5_on_gp35.36880NoNoYesNo99
32b.l17x5 b.l19x2 ccr5_on_gp99.90870NoNoYesNo69
33b.l17x5 b.l17x6 ccr5_on_gp99.84190NoNoYesNo69
34G.H2.06 b.l17x6 ccr5_on_gp99.82630YesNoYesNo99
35G.H2.06 b.l9x6 ccr5_on_gp1000YesNoYesNo98
36b.l7x2 b.l9x6 ccr5_on_gp83.37270YesNoYesNo98
37G.S2.01 b.l7x2 ccr5_on_gp32.65180YesNoYesNo99
38G.S2.01 G.S3.06 ccr5_on_gp32.63360YesNoYesNo95
39G.S3.04 G.S3.06 ccr5_on_gp82.5670NoNoYesNo65
40G.S1.01 G.S3.04 ccr5_on_gp82.49380NoNoNoNo66
41G.HN.53 G.S1.01 ccr5_on_gp82.47530NoNoNoNo16
42b.l10x1 b.l16x1 ccr5_on_gp27.72540YesNoNoNo34
43b.l16x1 b.l16x2 ccr5_on_gp34.07050NoNoNoNo49
44b.b15x2 b.b19x2 ccr5_on_gp34.99220YesNoYesNo66
45b.b19x2 b.b20x6 ccr5_on_gp35.08950YesNoYesNo66
46b.b20x4 b.b20x6 ccr5_on_gp64.28760YesNoYesNo86
47b.b20x2 b.b20x4 ccr5_on_gp64.41010YesNoYesNo68
48b.b20x2 b.l19x2 ccr5_on_gp64.48390YesNoYesNo69
49b.b14x5 b.b15x1 ccr5_on_gp14.59430YesNoNoNo59
50b.b15x1 b.b16x6 ccr5_on_gp14.41610NoNoYesNo98
51b.b16x6 b.b17x3 ccr5_on_gp18.93460YesNoNoNo85
52b.b17x3 g.h2x11 ccr5_on_gp19.94840NoNoNoNo59
53g.h2x11 g.h2x15 ccr5_on_gp28.1480NoNoYesNo99
54b.1x19 g.h2x15 ccr5_on_gp28.34290NoNoYesNo69
55b.1x19 b.b21x1 ccr5_on_gp28.57550NoNoNoNo67
56b.b17x5 b.b21x1 ccr5_on_gp28.76690YesNoNoNo77
57b.b17x5 b.b17x7 ccr5_on_gp29.18710YesNoNoNo78
58b.b17x7 b.b20x6 ccr5_on_gp29.21870NoNoYesNo86
59b.l5x5 b.l7x2 ccr5_on_gp33.95730YesNoYesNo99
60G.S3.06 b.l5x5 ccr5_on_gp33.02080YesNoYesNo59
61G.HN.53 G.hns1.03 ccr5_on_gp82.35150NoNoNoNo14
62G.s3h2.03 b.l9x6 ccr5_on_gp16.94620NoNoYesNo98
63G.H2.07 G.s3h2.03 ccr5_on_gp16.93540YesNoNoNo99
64G.H2.04 G.H2.07 ccr5_on_gp31.31430YesNoYesNo99
65G.H2.04 G.H3.08 ccr5_on_gp31.02570YesNoNoNo99
66G.H3.08 G.S4.04 ccr5_on_gp30.96510NoNoYesNo99
67G.H3.09 G.S4.04 ccr5_on_gp30.9820YesNoYesNo99
68G.H3.09 G.h4s6.01 ccr5_on_gp37.55790YesNoNoNo94
69G.H3.06 G.h4s6.01 ccr5_on_gp37.07040NoNoNoNo64
70G.H3.06 G.hgh4.02 ccr5_on_gp36.97290NoNoYesNo67
71G.HG.15 G.hgh4.02 ccr5_on_gp23.15780YesNoYesNo77
72G.HG.15 G.s4h3.04 ccr5_on_gp12.01290YesNoYesNo78
73G.HG.04 G.s4h3.04 ccr5_on_gp20.28680YesNoYesNo98
74G.H4.03 G.HG.04 ccr5_on_gp38.17160YesNoYesNo49
75G.H4.03 G.HG.01 ccr5_on_gp35.40120YesNoNoNo45
76G.HG.01 G.s6h5.02 ccr5_on_gp35.00450NoNoNoNo57
77G.H5.02 G.s6h5.02 ccr5_on_gp34.60770NoNoNoNo47
78G.H5.02 G.s6h5.05 ccr5_on_gp33.41730NoNoYesNo49
79G.H1.07 G.s6h5.05 ccr5_on_gp32.22510YesNoYesNo99
80G.H1.07 G.H5.04 ccr5_on_gp31.43250YesNoNoNo97
81G.H5.04 G.S2.08 ccr5_on_gp31.03550NoNoYesNo75
82G.H5.08 G.S2.08 ccr5_on_gp29.44270YesNoYesNo85
83G.H2.07 b.l7x2 ccr5_on_gp16.80820YesNoYesNo99
84G.hgh4.01 G.hgh4.02 ccr5_on_gp12.51220YesNoYesNo67
85G.hgh4.01 G.s4h3.04 ccr5_on_gp12.00880YesNoYesNo68
86G.HG.08 G.HG.15 ccr5_on_gp10.54830YesNoYesNo67
87G.HG.04 G.HG.08 ccr5_on_gp10.150YesNoYesNo96
88G.H5.08 G.S3.03 ccr5_on_gp26.6590YesNoYesNo87
89G.S1.04 G.S3.03 ccr5_on_gp15.52860NoNoYesNo77
90G.S1.04 G.S4.03 ccr5_on_gp15.13490NoNoNoNo77
91G.S1.05 G.h2s4.01 ccr5_on_gp18.48620NoNoYesNo99
923x56 I2x52 ccr5_on_gp81.91673.31494NoNoNoNo65
93I2x52 I2x55 ccr5_on_gp82.04110NoNoNoNo53
94G.hns1.03 I2x55 ccr5_on_gp82.10330NoNoNoNo43
953x47 5x57 ccr5_on_gp79.6270NoNoNoNo98
963x51 5x57 ccr5_on_gp79.68921.65926YesYesNoNo88
973x51 3x56 ccr5_on_gp79.90474.95269YesYesNoNo86
982x53 3x36 ccr5_on_gp29.66040YesNoYesNo77
993x36 3x40 ccr5_on_gp35.46760YesNoNoYes77
1005x54 6x44 ccr5_on_gp72.74330NoNoYesYes89
1013x47 5x54 ccr5_on_gp72.75230NoNoNoNo98
102b.l18x3 g.h2x11 ccr5_on_gp10.07130NoNoNoNo59
103b.b4x7 b.l2x5 ccr5_on_gp12.99650NoNoNoNo85
104b.l2x5 b.l4x2 ccr5_on_gp12.38690NoNoYesNo54
105b.b13x4 b.b13x5 ccr5_on_gp15.38010NoNoNoNo44
106b.b12x7 b.b13x4 ccr5_on_gp15.07340NoNoNoNo94
107b.b12x7 b.l10x4 ccr5_on_gp13.84540NoNoNoNo93
108b.l10x4 b.l12x1 ccr5_on_gp13.23330NoNoYesNo36
109b.b3x3 b.b6x5 ccr5_on_gp23.45430YesNoYesNo86
110b.b4x5 b.b5x5 ccr5_on_gp26.18020YesNoYesNo75
111b.b3x3 b.b4x5 ccr5_on_gp13.70470YesNoYesNo87
112b.b6x5 b.l8x1 ccr5_on_gp13.99810YesNoNoNo65
113b.b4x5 b.l8x1 ccr5_on_gp13.69510YesNoNoNo75
1143x33 Lig ccr5_on_gp15.61130YesNoYesYes50
1153x36 5x43 ccr5_on_gp19.30019.86597YesNoNoNo75
1165x43 6x55 ccr5_on_gp19.13140NoNoYesNo56
117G.S3.06 G.h2s4.01 ccr5_on_gp17.11530YesNoYesNo59
118b.b12x5 b.b13x5 ccr5_on_gp12.22590YesNoNoNo64
1192x53 3x32 Shared22.982316.5388YesNoYesYes77
1203x40 6x44 Shared35.54345.1369NoYesYesYes79
1213x36 6x48 Shared35.528431.1353YesNoYesYes79
1226x44 6x48 Shared35.624483.5257YesYesYesYes99
1233x32 Lig Shared15.726228.6984YesYesYesYes70
1243x36 3x37 Shared21.976529.279YesNoYesYes77
1253x33 3x37 Shared18.293740.1914YesNoYesYes57
1266x55 Lig Shared15.51248.0612YesNoYesYes60
1277x35 7x39 ccr5_off011.1489NoNoNoNo36
1281x39 7x42 ccr5_off0.85059910.2208YesYesYesNo88
1292x60 Lig ccr5_off6.0079623.1006YesYesYesYes70
1302x54 7x46 ccr5_off010.7691NoNoNoNo68
1312x53 7x46 ccr5_off0.3921212.5394YesNoNoNo78
1321x50 2x50 ccr5_off0.60101713.1271NoNoYesNo99
1332x50 7x49 ccr5_off0.93841514.7362YesNoYesNo99
1347x45 7x49 ccr5_off017.9329NoYesYesNo99
1356x48 7x45 ccr5_off0.055752133.4898YesYesNoYes99
1366x48 6x51 ccr5_off0100YesYesYesYes97
1376x51 6x55 ccr5_off0.65856849.7886YesYesYesNo76
1386x51 7x38 ccr5_off0.0083768753.5694YesYesNoNo76
1397x38 Lig ccr5_off0.0027173348.0863NoNoYesYes60
1407x53 8x50 ccr5_off026.2794YesYesYesYes98
1416x40 7x53 ccr5_off033.4612NoNoYesYes89
1423x43 6x40 ccr5_off034.9842NoNoNoNo88
1433x40 3x43 ccr5_off034.2711NoYesNoNo78
1442x44 2x48 ccr5_off3.6019412.2563NoNoNoNo66
1452x48 2x52 ccr5_off3.7716113.3278NoNoNoNo67
1462x52 4x50 ccr5_off014.3922NoNoYesYes79
1473x42 4x50 ccr5_off1.1447619.4775YesYesYesYes79
1483x42 4x49 ccr5_off0.15233922.5738YesYesNoNo76
1493x41 4x49 ccr5_off0.41438343.4633YesYesNoNo56
1503x37 3x41 ccr5_off1.2413746.746YesYesYesYes75
1513x32 3x33 ccr5_off0.042633936.7833YesYesYesNo75
1521x56 8x50 ccr5_off0.17190420.3878NoNoYesYes78
1531x56 8x53 ccr5_off018.8181NoNoNoNo75
1541x60 8x53 ccr5_off1.2046211.0414NoYesNoNo55
1552x38 2x42 ccr5_off0.19774615.1806YesNoYesYes67
1562x42 3x45 ccr5_off2.7316322.3552YesYesYesNo76
1573x45 4x49 ccr5_off0.17752623.3515YesNoNoNo66
1582x38 I2x57 ccr5_off0.025898911.9194YesNoYesYes66
159E1x50 E1x52 ccr5_off3.9816917.0979YesYesYesNo97
1602x60 E1x50 ccr5_off7.4670823.8855YesYesYesYes79
1612x63 E1x50 ccr5_off4.4765117.1552YesYesYesYes49
1622x63 Lig ccr5_off4.9626331.0063YesYesYesYes40
1633x25 E1x50 ccr5_off1.3272219.2051NoNoYesYes99
1643x22 E2.S169 ccr5_off020.5096NoYesNoNo34
1653x25 E2.S169 ccr5_off023.9034NoNoNoNo94
1663x22 3x26 ccr5_off0.49905110.2853NoYesNoNo37
1676x44 6x45 ccr5_off042.9652YesYesNoYes95
1683x51 5x61 ccr5_off013.0985YesYesNoYes88
1695x58 5x61 ccr5_off0.14465625.7418YesYesNoYes98
1705x54 5x58 ccr5_off034.7405NoNoYesYes89
1715x54 6x45 ccr5_off033.8267NoNoNoYes85
1724x64 E2.F182 ccr5_off1.9934510.7261YesYesYesYes55
173E2.F182 Lig ccr5_off4.4699513.3493YesYesYesYes50
1747x48 7x52 ccr5_off012.7258NoYesNoNo68
1757x45 7x48 ccr5_off017.4599NoYesNoYes96
1767x30 E3.L266 ccr5_off024.0503NoNoNoNo54
1776x58 7x30 ccr5_off2.6525227.0248NoNoNoNo45
1786x58 6x61 ccr5_off015.0516NoNoYesNo44
1796x61 Lig ccr5_off4.9742116.2486YesNoYesYes40
1806x58 7x34 ccr5_off0.8221714.9441NoNoYesNo45
1817x34 Lig ccr5_off0.016397716.288YesNoYesYes50
1827x26 E3.L266 ccr5_off1.9958112.0807NoNoNoNo14

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Midway



Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Node1Node2OwnerNet1LinkStrengthNet2LinkStrengthComm1Comm2Node1ShellNode2Shell
E2x52LigShared16.773.931110
E2.F182LigShared7.134.811110
5x40LigShared7.883.941110
6x55LigShared4.445.191110
2x60LigShared28.3722.761110
3x29LigShared8.747.7851110
4x65Ligccr5_off6.9901010
3x32LigShared13.918.931110
7x38LigShared7.373.1151110
2x63LigShared7.037.621110
7x35LigShared17.857.8251110
E2x51LigShared18.059.41010
1x24LigShared8.855.411110
7x31LigShared11.228.031010
7x34LigShared7.885.1351110
1x28LigShared4.2312.9450110
1x31Ligccr5_off4.7300010
E2.E172LigShared22.5925.8951110
E2.T177LigShared4.254.2451110
LigNT.P19Shared22.3113.221101
LigNT.C20ccr5_off4.1901101
6x61LigShared11.285.051110
E3.N267LigShared7.172.71110
7x27LigShared5.283.960110
LigNT.S17Shared11.043.261101
E2.K171Ligccr5_off10.801010
E2.G173Ligccr5_off5.1201010
E2.Q170LigShared5.869.041110
E2.Y184LigShared22.8820.5151010
5x32LigShared23.7720.0851110
7x24NT.C20Shared7.287.280021
7x28NT.C20ccr5_off4.7200121
1x241x27Shared19.733.7951112
1x247x31ccr5_off6.9101111
2x533x32Shared10.3215.4750021
2x537x42Shared4.985.5950022
2x562x60Shared9.73.640121
2x60E1x50Shared6.563.751112
2x603x32ccr5_off5.7901111
2x607x42ccr5_off4.6501112
2x63E1x50Shared9.659.1651112
2x63E2.H175ccr5_off6.5301112
2x63E2.T177Shared4.994.371111
2x63E2x50ccr5_off4.0301112
E1x50E2x50Shared16.9811.11122
3x22E2.R168Shared13.263.6150021
3x22E2.S169ccr5_off7.4500022
3x294x65Shared14.138.6351111
3x323x33Shared8.255.671111
3x333x37Shared5.365.360112
3x334x61Shared19.3311.7750112
4x605x39ccr5_off6.3200021
4x615x39ccr5_off9.2406021
4x615x42ccr5_off5.606022
4x64E2.F182Shared10.725.8950121
4x645x35Shared15.0313.530122
4x645x39ccr5_off7.0300121
E2.E172E2.Q170ccr5_off12.7401111
E2.H181E2.Q170Shared11.1311.7450111
E2.K171E2.Y176Shared17.917.7651012
E2.E172E2.T177ccr5_off16.9301111
E2.H175E2.T177ccr5_off6.8501021
E2.H181E2x51ccr5_off5.5800111
E2.F182E2x52ccr5_off6.6101111
5x36E2.F182ccr5_off6.200021
E2.S185E2.Y184ccr5_off6.3600021
5x325x36Shared8.366.571112
5x395x42Shared6.783.396112
5x406x55Shared4.422.9451111
5x406x59Shared14.1312.561112
6x486x51ccr5_off6.7502121
6x516x55Shared11.7215.8250111
6x517x37Shared4.998.740112
6x517x38Shared6.7313.470111
6x547x37Shared6.354.760022
6x586x61ccr5_off6.600111
6x587x30Shared5.496.180112
6x587x34Shared5.614.910111
6x61E3.N267ccr5_off3.9601111
6x62E3.N267Shared13.151.3150021
7x30E3.L266ccr5_off5.5400022
7x357x38ccr5_off11.4701111
7x357x39ccr5_off5.6701112
3x21E1x50ccr5_off2.8100022
E2.G173E2.L174ccr5_off1.7101011
6x65E3.N267ccr5_off1.700021
NT.S17NT.T16ccr5_off1.601011
NT.E18NT.P19Shared1.573.930111
LigNT.Q21Shared1.446.891101
1x25NT.Q21ccr5_off1.3700021
LigNT.E18ccr5_on_gp07.091101
1x241x28ccr5_on_gp04.311111
1x247x28ccr5_on_gp07.691112
1x317x35ccr5_on_gp04.550011
2x563x28ccr5_on_gp03.6850122
2x563x32ccr5_on_gp04.9950121
2x602x63ccr5_on_gp05.7851111
2x603x28ccr5_on_gp07.9751112
2x603x29ccr5_on_gp03.0351111
2x60E2x50ccr5_on_gp03.2651112
E1x50E2.S169ccr5_on_gp04.941122
3x293x33ccr5_on_gp03.241111
3x33Ligccr5_on_gp03.4350110
3x375x42ccr5_on_gp08.0650122
4x65E2x52ccr5_on_gp05.61011
E2.Q170E2.R168ccr5_on_gp05.261111
E2.H181E2.R168ccr5_on_gp013.5450111
E2.H181Ligccr5_on_gp07.80110
5x32E2.F182ccr5_on_gp07.7351111
5x35E2.F182ccr5_on_gp05.018121
5x39E2.F182ccr5_on_gp03.5156111
5x366x59ccr5_on_gp06.0050022
5x39Ligccr5_on_gp05.7256110
5x436x55ccr5_on_gp04.9950021
6x51Ligccr5_on_gp03.170110
6x547x34ccr5_on_gp06.8450021
6x557x34ccr5_on_gp04.9451111
6x58Ligccr5_on_gp06.7150110
6x61E3.L266ccr5_on_gp03.991112
6x617x27ccr5_on_gp03.611111
6x617x30ccr5_on_gp05.321112
E2.R168Ligccr5_on_gp03.490110
1x277x28ccr5_on_gp02.9550122
3x327x38ccr5_on_gp04.491111
E2.E172E2.H175ccr5_on_gp08.6151112
LigNT.T16ccr5_on_gp02.5851101
E2.E172E2.G173ccr5_on_gp02.4551111
7x247x28ccr5_on_gp02.360022
1x32Ligccr5_on_gp02.3150010
E2.K171E2.S169ccr5_on_gp02.2951012
3x21E2.K171ccr5_on_gp01.7450021
E2.L174Ligccr5_on_gp01.330010

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
Id Description
ccr5_on_gp 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
ccr5_off 5UIW-CCR5-5P7-CCL5
Network Difference
Value ccr5_on_gp ccr5_off
Imin 2.905 3.89
Number of Linked Nodes 901 283
Number of Specific Nodes 623 (69.15%) 5  (1.77%)
Number of Shared Nodes 278 (30.85%) 278  (98.23%)
Number of Links 1127 320
Number of Specific Links 933 (82.79%) 126  (39.38%)
Number of Shared Links 194 (17.21%) 194  (60.63%)
Number of Hubs 184 35
Number of Specific Hubs 162 (88.04%) 13  (37.14%)
Number of Shared Hubs 22 (11.96%) 22  (62.86%)
Average % Shared Neighbours (Jaccard) 13.47
Average % Shared Neighbours (Otsuka) 17.13
Average % Shared Neighbours (Overlap Coefficient) 20.82
Average % Shared Cliques (k3-6) 51.18
Graphlets Similarity 0.616917
Paths Difference
Value ccr5_on_gp ccr5_off
Number Of Nodes in MetaPath 115 63
Specific Nodes in MetaPath 103 (89.57%) 51  (80.95%)
Shared Nodes in MetaPath 278 (30.85%) 278  (30.85%)
Number Of Links MetaPath 126 64
Specific Links in MetaPath 118 (93.65%) 56  (87.50%)
Shared Links in MetaPath 194 (17.21%) 194  (17.21%)
Number of Shortest Paths 6642641 64168
Length Of Smallest Path 3 3
Average Path Length 44.9229 11.6651
Length of Longest Path 71 28
Minimum Path Strength 0.675 1.405
Average Path Strength 5.89751 7.41246
Maximum Path Strength 24.3275 20.6133
Minimum Path Correlation 0.7 0.7
Average Path Correlation 0.993256 0.941866
Maximum Path Correlation 1 0.99
Minimum % Of Corr. Nodes 1.63934 4.7619
Average % Of Corr. Nodes 28.9921 59.2819
Maximum % Of Corr. Nodes 100 100
Minimum Path Hubs % 0 0
Average Path Hubs % 51.3579 45.3969
Maximum Path Hubs % 100 100

Details about the values in these tables can be found in the corresponding documentation page .

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

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