psnGPCR

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Orange: nodes, hubs and links specific of ccr_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of ccr_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	ccr_off Int. Strength	ccr_on Int. Strength	ccr_off Hub1?	ccr_on Hub1?	ccr_off Hub2?	ccr_on Hub2?	ConSurf1	ConSurf2
1	1x31	Lig	ccr_off	100	0	No	No	Yes	Yes	3	0
2	1x35	7x39	ccr_off	100	0	Yes	No	No	No	6	5
3	1x35	Lig	ccr_off	100	0	Yes	No	Yes	Yes	6	0
4	1x42	7x47	ccr_off	100	0	No	No	No	No	7	8
5	1x51	2x51	ccr_off	100	0	No	No	No	No	4	7
6	1x53	7x53	ccr_off	100	0	No	No	Yes	Yes	9	9
7	1x56	8x53	ccr_off	100	0	No	No	No	Yes	7	5
8	2x44	I1x50	ccr_off	100	0	No	No	No	No	6	6
9	2x43	3x46	ccr_off	100	0	No	No	No	No	8	9
10	2x43	7x53	ccr_off	100	0	No	No	Yes	Yes	8	9
11	2x52	4x50	ccr_off	100	0	No	No	Yes	Yes	7	9
12	2x54	7x46	ccr_off	100	0	No	No	No	No	6	8
13	2x56	3x28	ccr_off	100	0	No	No	Yes	No	7	6
14	2x60	E1x50	ccr_off	100	0	Yes	Yes	Yes	Yes	6	8
15	2x60	7x42	ccr_off	100	0	Yes	Yes	Yes	Yes	6	7
16	2x62	E1x51	ccr_off	100	0	No	No	No	No	4	3
17	3x26	E2	ccr_off	100	0	No	No	Yes	Yes	7	3
18	3x33	3x37	ccr_off	100	0	Yes	No	Yes	Yes	5	7
19	3x36	6x44	ccr_off	100	0	Yes	Yes	Yes	Yes	7	9
20	3x37	5x46	ccr_off	100	0	Yes	Yes	No	No	7	4
21	3x40	5x50	ccr_off	100	0	No	No	Yes	Yes	8	8
22	3x40	6x44	ccr_off	100	0	No	No	Yes	Yes	8	9
23	3x43	6x40	ccr_off	100	0	No	No	Yes	No	8	8
24	3x43	6x41	ccr_off	100	0	No	No	No	No	8	8
25	3x50	6x30	ccr_off	100	0	No	No	No	Yes	9	5
26	3x50	6x33	ccr_off	100	0	No	No	No	No	9	7
27	3x54	6x31	ccr_off	100	0	No	No	No	No	8	4
28	4x61	5x39	ccr_off	100	0	No	No	No	No	4	5
29	4x64	5x32	ccr_off	100	0	Yes	No	No	No	4	4
30	4x65	Lig	ccr_off	100	0	No	No	Yes	Yes	5	0
31	5x33	5x37	ccr_off	100	0	No	No	No	No	3	3
32	5x35	5x38	ccr_off	100	0	Yes	Yes	No	No	3	4
33	5x40	6x55	ccr_off	100	0	No	No	No	No	5	6
34	5x50	6x45	ccr_off	100	0	Yes	Yes	Yes	No	8	5
35	5x51	6x45	ccr_off	100	0	No	No	Yes	No	6	5
36	5x54	6x41	ccr_off	100	0	No	No	No	No	8	8
37	5x58	6x38	ccr_off	100	0	Yes	Yes	No	No	8	4
38	6x28	6x31	ccr_off	100	0	No	No	No	No	3	4
39	6x29	6x33	ccr_off	100	0	No	No	No	No	4	7
40	6x29	8x48	ccr_off	100	0	No	No	No	No	4	5
41	6x32	8x48	ccr_off	100	0	No	No	No	No	6	5
42	6x38	6x42	ccr_off	100	0	No	No	No	No	4	5
43	6x39	7x52	ccr_off	100	0	No	No	No	No	5	8
44	6x39	7x56	ccr_off	100	0	No	No	No	No	5	6
45	6x40	7x49	ccr_off	100	0	Yes	No	No	Yes	8	9
46	6x40	7x53	ccr_off	100	0	Yes	No	Yes	Yes	8	9
47	6x41	6x45	ccr_off	100	0	No	No	Yes	No	8	5
48	6x43	7x52	ccr_off	100	0	No	No	No	No	6	8
49	6x44	6x45	ccr_off	100	0	Yes	Yes	Yes	No	9	5
50	6x48	6x51	ccr_off	100	0	Yes	Yes	Yes	No	9	6
51	6x57	6x64	ccr_off	100	0	No	No	No	No	4	1
52	6x58	7x34	ccr_off	100	0	No	No	No	No	4	4
53	6x61	7x27	ccr_off	100	0	No	No	No	No	4	2
54	6x62	6x63	ccr_off	100	0	No	No	No	No	3	1
55	7x42	Lig	ccr_off	100	0	Yes	Yes	Yes	Yes	7	0
56	5x40	Lig	ccr_off	100	0	No	No	Yes	Yes	5	0
57	1x24	Lig	ccr_off	100	0	No	No	Yes	Yes	0	0
58	1x24	1x27	ccr_off	100	0	No	No	No	No	0	5
59	1x25	1x29	ccr_off	100	0	No	No	No	No	0	4
60	2x63	E2	ccr_off	100	0	No	No	Yes	Yes	4	3
61	E1x49	E1x51	ccr_off	100	0	No	No	No	No	4	3
62	5x31	E2	ccr_off	100	0	No	No	Yes	Yes	0	3
63	5x32	5x36	ccr_off	100	0	No	No	No	No	4	3
64	6x62	E3	ccr_off	100	0	No	No	Yes	No	3	0
65	6x63	6x64	ccr_off	100	0	No	No	No	No	1	1
66	7x23	7x26	ccr_off	100	0	No	No	No	No	0	1
67	7x35	7x38	ccr_off	100	0	No	No	No	Yes	4	5
68	2x39	3x50	ccr_off	0	0	No	No	No	No	7	9
69	5x43	6x52	ccr_off	50	0	No	No	No	No	5	8
70	2x49	3x39	ccr_off	0	0	No	No	No	No	8	9
71	1x38	7x43	ccr_off	50	0	No	No	No	No	5	5
72	3x51	5x61	ccr_off	50	0	Yes	Yes	No	No	8	8
73	1x60	8x57	ccr_off	50	0	Yes	No	No	No	5	5
74	5x42	5x46	ccr_off	50	0	No	No	No	No	4	4
75	2x48	4x50	ccr_off	0	0	No	No	Yes	Yes	5	9
76	2x40	I1x51	ccr_off	50	0	No	No	No	No	8	6
77	2x37	2x39	ccr_off	0	0	No	No	No	No	7	7
78	6x35	7x56	ccr_off	50	0	No	No	No	No	5	6
79	3x54	6x30	ccr_off	50	0	No	No	No	Yes	8	5
80	3x55	5x64	ccr_off	50	0	No	No	No	No	7	5
81	1x42	7x43	ccr_off	0	0	No	No	No	No	7	5
82	4x60	5x39	ccr_off	50	0	No	No	No	No	7	5
83	1x60	8x56	ccr_off	0	0	Yes	No	No	No	5	4
84	1x60	CT	ccr_off	50	0	Yes	No	No	No	5	4
85	1x53	1x57	ccr_off	0	0	No	No	No	Yes	9	7
86	3x44	3x48	ccr_off	0	0	No	No	No	No	8	6
87	5x61	5x65	ccr_off	50	0	No	No	No	No	8	8
88	3x48	3x52	ccr_off	0	0	No	No	No	No	6	5
89	3x21	E1x50	ccr_off	0	0	No	No	Yes	Yes	7	8
90	7x53	8x49	ccr_off	50	0	Yes	Yes	No	No	9	6
91	3x41	4x53	ccr_off	0	0	Yes	No	No	No	5	8
92	5x62	5x66	ccr_off	50	0	No	No	No	No	4	4
93	6x27	6x28	ccr_off	50	0	No	No	No	No	1	3
94	8x55	8x59	ccr_off	50	0	No	No	No	No	5	0
95	1x53	2x47	ccr_off	0	0	No	No	No	No	9	9
96	8x50	8x54	ccr_off	50	0	No	Yes	No	No	8	7
97	6x36	7x53	ccr_off	0	0	No	No	Yes	Yes	8	9
98	7x28	NT	ccr_off	50	0	No	No	Yes	Yes	3	0
99	1x54	1x58	ccr_off	0	0	No	No	No	No	8	3
100	7x23	7x25	ccr_off	50	0	No	No	No	No	0	0
101	8x56	8x59	ccr_off	50	0	No	No	No	No	4	0
102	1x25	1x26	ccr_off	50	0	No	No	No	No	0	0
103	3x26	4x62	ccr_off	0	0	No	No	No	No	7	5
104	1x34	1x35	ccr_off	50	0	No	No	Yes	No	5	6
105	7x26	7x29	ccr_off	50	0	No	No	No	No	1	3
106	1x47	2x55	ccr_off	0	0	No	No	No	No	6	4
107	5x59	5x60	ccr_off	0	0	No	No	No	No	4	4
108	3x27	3x28	ccr_off	0	0	No	No	Yes	No	4	6
109	4x55	4x59	ccr_off	0	0	No	No	No	No	3	5
110	2x52	3x35	ccr_off	0	0	No	No	No	No	7	8
111	2x38	I2x53	ccr_off	0	0	Yes	Yes	No	No	6	5
112	1x45	1x46	ccr_off	0	0	No	No	No	No	6	8
113	3x52	I2x51	ccr_off	0	0	No	No	No	No	5	5
114	2x38	4x38	ccr_off	0	0	Yes	Yes	No	No	6	7
115	7x36	Lig	ccr_off	0	0	No	No	Yes	Yes	5	0
116	1x29	1x33	ccr_off	0	0	No	No	No	No	4	5
117	1x60	8x52	ccr_off	0	0	Yes	No	No	No	5	4
118	5x41	6x60	ccr_off	0	0	No	No	No	Yes	4	4
119	I2x54	I2x57	ccr_off	0	0	No	No	No	Yes	5	7
120	1x32	2x65	ccr_off	0	0	No	No	No	No	7	4
121	6x65	E3	ccr_off	0	0	No	No	Yes	No	0	0
122	5x44	5x48	ccr_off	0	0	No	No	No	No	5	5
123	4x44	4x45	ccr_off	0	0	No	No	No	No	3	5
124	I2x54	I2x56	ccr_off	0	0	No	No	No	No	5	3
125	5x51	5x55	ccr_off	0	0	No	No	No	No	6	4
126	7x48	7x51	ccr_off	0	0	No	No	No	No	6	7
127	3x22	3x23	ccr_off	0	0	No	No	No	No	3	3
128	5x65	5x66	ccr_off	0	0	No	No	No	No	8	4
129	1x25	NT	ccr_off	0	0	No	No	Yes	Yes	0	0
130	1x59	I1x49	ccr_off	0	0	No	Yes	No	No	4	6
131	1x27	7x32	Shared	100	100	No	No	No	No	5	1
132	1x35	1x39	Shared	100	100	Yes	No	Yes	Yes	6	7
133	1x36	1x37	Shared	100	100	No	No	No	No	5	5
134	1x39	2x57	Shared	100	100	Yes	Yes	No	Yes	7	7
135	1x39	7x39	Shared	100	60	Yes	Yes	No	No	7	5
136	1x39	7x42	Shared	100	100	Yes	Yes	Yes	Yes	7	7
137	1x41	1x45	Shared	100	30	No	No	No	No	4	6
138	1x43	1x47	Shared	100	100	No	No	No	No	7	6
139	1x43	2x58	Shared	100	100	No	No	No	No	7	9
140	1x47	1x51	Shared	100	46.6667	No	No	No	No	6	4
141	1x49	7x50	Shared	100	0	No	No	No	No	7	9
142	1x50	2x50	Shared	100	100	No	No	No	Yes	9	9
143	1x50	7x50	Shared	100	100	No	No	No	No	9	9
144	1x54	2x44	Shared	100	60	No	No	No	No	8	6
145	1x58	1x59	Shared	100	20	No	No	No	Yes	3	4
146	1x60	8x53	Shared	100	100	Yes	No	No	Yes	5	5
147	2x40	I1x48	Shared	100	26.6667	No	No	No	No	8	6
148	2x37	2x40	Shared	100	100	No	No	No	No	7	8
149	2x38	2x42	Shared	100	100	Yes	Yes	Yes	Yes	6	7
150	2x38	3x49	Shared	100	100	Yes	Yes	No	Yes	6	8
151	2x39	3x49	Shared	100	100	No	No	No	Yes	7	8
152	2x42	3x45	Shared	100	100	Yes	Yes	No	No	7	6
153	2x42	4x45	Shared	100	100	Yes	Yes	No	No	7	5
154	2x45	3x42	Shared	100	100	No	No	Yes	Yes	9	7
155	2x45	4x46	Shared	100	100	No	No	No	No	9	7
156	2x45	4x50	Shared	100	100	No	No	Yes	Yes	9	9
157	2x46	3x43	Shared	100	100	No	No	No	No	9	8
158	2x49	3x38	Shared	100	100	No	No	No	No	8	7
159	2x50	7x49	Shared	100	100	No	Yes	No	Yes	9	9
160	2x53	3x32	Shared	100	100	No	Yes	No	Yes	6	6
161	2x53	7x42	Shared	100	100	No	Yes	Yes	Yes	6	7
162	2x53	7x46	Shared	100	100	No	Yes	No	No	6	8
163	2x56	2x60	Shared	100	50	No	No	Yes	Yes	7	6
164	2x59	E1x52	Shared	100	100	No	No	No	Yes	6	7
165	2x59	3x28	Shared	100	100	No	No	Yes	No	6	6
166	2x60	Lig	Shared	100	100	Yes	Yes	Yes	Yes	6	0
167	2x62	2x66	Shared	100	100	No	No	No	No	4	4
168	2x62	E1x52	Shared	100	30	No	No	No	Yes	4	7
169	2x63	E1x50	Shared	100	100	No	No	Yes	Yes	4	8
170	E1x49	E2	Shared	100	100	No	No	Yes	Yes	4	3
171	E1x50	E1x52	Shared	100	100	Yes	Yes	No	Yes	8	7
172	3x25	E1x50	Shared	100	100	No	No	Yes	Yes	9	8
173	E1x50	E2	Shared	100	100	Yes	Yes	Yes	Yes	8	3
174	E1x50	E2x50	Shared	100	100	Yes	Yes	No	No	8	9
175	3x22	3x26	Shared	100	100	No	No	No	No	3	7
176	3x22	E2	Shared	100	100	No	No	Yes	Yes	3	3
177	3x24	3x28	Shared	100	100	No	No	Yes	No	5	6
178	3x25	E2x50	Shared	100	100	No	No	No	No	9	9
179	3x29	4x65	Shared	100	100	No	No	No	No	6	5
180	3x29	Lig	Shared	100	100	No	No	Yes	Yes	6	0
181	3x32	3x33	Shared	100	100	No	Yes	Yes	No	6	5
182	3x32	Lig	Shared	100	100	No	Yes	Yes	Yes	6	0
183	3x33	4x61	Shared	100	100	Yes	No	No	No	5	4
184	3x34	4x57	Shared	100	100	No	No	No	No	6	7
185	3x36	3x37	Shared	100	100	Yes	Yes	Yes	Yes	7	7
186	3x36	5x43	Shared	100	100	Yes	Yes	No	No	7	5
187	3x36	6x48	Shared	100	100	Yes	Yes	Yes	Yes	7	9
188	3x37	4x56	Shared	100	100	Yes	Yes	No	No	7	5
189	3x38	4x50	Shared	100	100	No	No	Yes	Yes	7	9
190	3x41	4x49	Shared	100	100	Yes	No	No	No	5	7
191	3x41	4x52	Shared	100	26.6667	Yes	No	No	No	5	4
192	3x41	5x46	Shared	100	26.6667	Yes	No	No	No	5	4
193	3x42	4x46	Shared	100	100	Yes	Yes	No	No	7	7
194	3x42	4x49	Shared	100	100	Yes	Yes	No	No	7	7
195	3x42	4x50	Shared	100	100	Yes	Yes	Yes	Yes	7	9
196	3x44	5x50	Shared	100	100	No	No	Yes	Yes	8	8
197	3x45	4x49	Shared	100	100	No	No	No	No	6	7
198	3x47	5x58	Shared	100	100	No	No	Yes	Yes	9	8
199	3x51	3x55	Shared	100	100	Yes	Yes	No	No	8	7
200	3x51	3x56	Shared	100	100	Yes	Yes	No	No	8	6
201	3x51	5x57	Shared	100	100	Yes	Yes	No	No	8	7
202	3x55	3x56	Shared	100	100	No	No	No	No	7	6
203	4x41	4x45	Shared	100	100	No	No	No	No	4	5
204	4x63	4x64	Shared	100	100	No	No	Yes	No	5	4
205	4x64	E2	Shared	100	100	Yes	No	Yes	Yes	4	3
206	4x64	5x35	Shared	100	100	Yes	No	Yes	Yes	4	3
207	E2	E2	Shared	100	100	Yes	Yes	Yes	Yes	3	3
208	E2	E2x52	Shared	100	100	Yes	Yes	No	Yes	3	4
209	5x35	E2	Shared	100	100	Yes	Yes	Yes	Yes	3	3
210	5x36	E2	Shared	100	100	No	No	Yes	Yes	3	3
211	5x39	E2	Shared	100	100	No	No	Yes	Yes	5	3
212	5x37	6x60	Shared	100	40	No	No	No	Yes	3	4
213	5x40	6x59	Shared	100	100	No	No	No	No	5	5
214	5x44	6x56	Shared	100	100	No	No	No	No	5	6
215	5x47	6x52	Shared	100	100	No	Yes	No	No	8	8
216	5x58	6x37	Shared	100	100	Yes	Yes	No	No	8	7
217	6x40	7x52	Shared	100	100	Yes	No	No	No	8	8
218	6x44	6x48	Shared	100	100	Yes	Yes	Yes	Yes	9	9
219	6x44	7x45	Shared	100	100	Yes	Yes	No	Yes	9	9
220	6x47	7x45	Shared	100	100	Yes	Yes	No	Yes	8	9
221	6x47	7x48	Shared	100	40	Yes	Yes	No	No	8	6
222	6x48	7x41	Shared	100	100	Yes	Yes	No	No	9	8
223	6x48	7x45	Shared	100	100	Yes	Yes	No	Yes	9	9
224	6x51	6x55	Shared	100	100	Yes	No	No	No	6	6
225	6x51	7x37	Shared	100	100	Yes	No	No	Yes	6	7
226	6x51	7x38	Shared	100	100	Yes	No	No	Yes	6	5
227	6x54	7x34	Shared	100	100	No	No	No	No	5	4
228	6x54	7x37	Shared	100	100	No	No	No	Yes	5	7
229	6x58	7x30	Shared	100	33.3333	No	No	No	Yes	4	4
230	6x59	6x60	Shared	100	40	No	No	No	Yes	5	4
231	7x35	Lig	Shared	100	100	No	No	Yes	Yes	4	0
232	7x38	Lig	Shared	100	100	No	Yes	Yes	Yes	5	0
233	Lig	Lig	Shared	100	100	Yes	Yes	Yes	Yes	0	0
234	E2x52	Lig	Shared	100	100	No	Yes	Yes	Yes	4	0
235	E2	Lig	Shared	100	100	Yes	Yes	Yes	Yes	3	0
236	E2x51	Lig	Shared	100	100	No	No	Yes	Yes	4	0
237	7x31	Lig	Shared	100	100	No	No	Yes	Yes	4	0
238	7x34	Lig	Shared	100	100	No	No	Yes	Yes	4	0
239	Lig	NT	Shared	100	100	Yes	Yes	Yes	Yes	0	0
240	6x61	Lig	Shared	100	100	No	No	Yes	Yes	4	0
241	5x32	Lig	Shared	100	100	No	No	Yes	Yes	4	0
242	3x49	I2x57	Shared	100	100	No	Yes	No	Yes	8	7
243	5x34	5x35	Shared	100	100	No	No	Yes	Yes	2	3
244	3x44	5x53	Shared	50	100	No	No	No	No	8	6
245	1x36	2x64	Shared	0	30	No	No	No	No	5	5
246	2x56	3x31	Shared	50	60	No	No	No	No	7	4
247	6x47	7x40	Shared	50	40	Yes	Yes	No	No	8	7
248	7x24	NT	Shared	50	100	No	No	Yes	Yes	0	0
249	5x58	5x61	Shared	50	100	Yes	Yes	No	No	8	8
250	5x54	5x58	Shared	0	100	No	No	Yes	Yes	8	8
251	E3	Lig	Shared	50	100	Yes	No	Yes	Yes	0	0
252	5x44	6x52	Shared	50	100	No	No	No	No	5	8
253	3x30	4x62	Shared	0	100	No	No	No	No	6	5
254	6x50	7x37	Shared	0	20	No	No	No	Yes	9	7
255	3x53	I2x57	Shared	50	100	No	No	No	Yes	8	7
256	3x33	4x57	Shared	50	20	Yes	No	No	No	5	7
257	1x35	2x64	Shared	0	100	Yes	No	No	No	6	5
258	1x56	8x50	Shared	50	100	No	No	No	Yes	7	8
259	3x34	4x54	Shared	0	100	No	No	No	No	6	4
260	5x461	5x50	Shared	50	46.6667	No	No	Yes	Yes	6	8
261	5x47	6x49	Shared	50	100	No	Yes	No	Yes	8	5
262	8x53	I1x48	Shared	50	100	No	Yes	No	No	5	6
263	5x65	6x34	Shared	50	40	No	No	No	Yes	8	6
264	8x48	8x51	Shared	50	100	No	No	No	No	5	8
265	2x42	4x42	Shared	50	100	Yes	Yes	No	No	7	7
266	5x52	5x56	Shared	50	20	No	No	No	No	4	4
267	2x41	I1x50	Shared	50	16.6667	No	No	No	No	7	6
268	1x30	1x34	Shared	0	26.6667	No	No	No	No	4	5
269	2x44	2x48	Shared	0	36.6667	No	No	No	No	6	5
270	1x36	2x65	Shared	0	26.6667	No	No	No	No	5	4
271	1x50	2x51	Shared	0	30	No	No	No	No	9	7
272	1x39	2x61	Shared	0	30	Yes	Yes	No	No	7	7
273	5x60	5x63	Shared	0	20	No	No	No	No	4	4
274	6x47	7x43	Shared	0	100	Yes	Yes	No	No	8	5
275	4x59	4x60	Shared	0	20	No	No	No	No	5	7
276	1x46	2x54	Shared	0	20	No	No	No	No	8	6
277	6x54	7x33	Shared	0	20	No	No	No	No	5	5
278	7x51	7x55	Shared	0	100	No	No	No	No	7	7
279	5x49	5x50	Shared	0	100	No	No	Yes	Yes	6	8
280	8x54	8x58	Shared	0	20	No	No	No	No	7	6
281	4x38	4x40	Shared	50	40	No	No	No	No	7	4
282	3x51	5x60	Shared	0	20	Yes	Yes	No	No	8	4
283	6x42	6x46	Shared	0	26.6667	No	No	No	No	5	6
284	1x28	Lig	Shared	50	100	No	No	Yes	Yes	5	0
285	I2x52	I2x56	Shared	50	100	No	No	No	No	4	3
286	1x55	1x59	Shared	0	40	No	No	No	Yes	3	4
287	4x51	4x55	Shared	0	20	No	No	No	No	4	3
288	1x48	1x49	Shared	0	10	No	No	No	No	4	7
289	7x56	8x47	Shared	0	0	No	No	No	No	6	8
290	2x41	4x39	Shared	0	0	No	No	No	No	7	3
291	6x49	6x53	Shared	0	20	No	Yes	No	No	5	6
292	7x26	E3	Shared	0	100	No	No	Yes	No	1	0
293	5x41	5x45	Shared	0	20	No	No	No	No	4	4
294	1x52	8x54	Shared	0	100	No	No	No	No	6	7
295	7x54	8x50	Shared	0	100	No	No	No	Yes	7	8
296	1x44	1x45	Shared	0	20	No	No	No	No	6	6
297	4x39	4x43	Shared	0	20	No	No	No	No	3	4
298	4x44	4x48	Shared	0	0	No	No	No	No	3	4
299	4x48	4x52	Shared	0	0	No	No	No	No	4	4
300	4x47	4x51	Shared	0	0	No	No	No	No	4	4
301	NT	NT	ccr_on	0	100	Yes	Yes	Yes	Yes	0	0
302	1x35	7x35	ccr_on	0	100	Yes	No	No	No	6	4
303	1x38	7x39	ccr_on	0	100	No	No	No	No	5	5
304	1x53	8x50	ccr_on	0	100	No	No	No	Yes	9	8
305	1x59	8x57	ccr_on	0	100	No	Yes	No	No	4	5
306	2x42	3x46	ccr_on	0	100	Yes	Yes	No	No	7	9
307	2x42	3x49	ccr_on	0	100	Yes	Yes	No	Yes	7	8
308	2x53	3x35	ccr_on	0	100	No	Yes	No	No	6	8
309	2x60	3x32	ccr_on	0	100	Yes	Yes	No	Yes	6	6
310	3x24	E1x52	ccr_on	0	100	No	No	No	Yes	5	7
311	3x36	3x40	ccr_on	0	100	Yes	Yes	No	No	7	8
312	3x40	6x48	ccr_on	0	100	No	No	Yes	Yes	8	9
313	3x43	7x49	ccr_on	0	100	No	No	No	Yes	8	9
314	3x43	7x53	ccr_on	0	100	No	No	Yes	Yes	8	9
315	3x46	7x53	ccr_on	0	100	No	No	Yes	Yes	9	9
316	3x47	5x57	ccr_on	0	100	No	No	No	No	9	7
317	3x50	5x58	ccr_on	0	100	No	No	Yes	Yes	9	8
318	3x50	7x53	ccr_on	0	100	No	No	Yes	Yes	9	9
319	3x54	5x61	ccr_on	0	100	No	No	No	No	8	8
320	4x65	E2x52	ccr_on	0	100	No	No	No	Yes	5	4
321	E2	E2x51	ccr_on	0	100	Yes	Yes	No	No	3	4
322	E2x51	E2x52	ccr_on	0	100	No	No	No	Yes	4	4
323	5x32	E2	ccr_on	0	100	No	No	Yes	Yes	4	3
324	5x47	5x51	ccr_on	0	100	No	Yes	No	No	8	6
325	5x50	6x44	ccr_on	0	100	Yes	Yes	Yes	Yes	8	9
326	5x54	6x44	ccr_on	0	100	No	No	Yes	Yes	8	9
327	5x58	6x41	ccr_on	0	100	Yes	Yes	No	No	8	8
328	5x62	6x37	ccr_on	0	100	No	No	No	No	4	7
329	6x29	I3	ccr_on	0	100	No	No	No	No	4	0
330	6x36	7x56	ccr_on	0	100	No	No	No	No	8	6
331	6x45	6x49	ccr_on	0	100	Yes	No	No	Yes	5	5
332	6x49	6x50	ccr_on	0	100	No	Yes	No	No	5	9
333	6x57	7x30	ccr_on	0	100	No	No	No	Yes	4	4
334	7x38	7x42	ccr_on	0	100	No	Yes	Yes	Yes	5	7
335	7x45	7x49	ccr_on	0	100	No	Yes	No	Yes	9	9
336	7x49	7x53	ccr_on	0	100	No	Yes	Yes	Yes	9	9
337	7x52	7x53	ccr_on	0	100	No	No	Yes	Yes	8	9
338	7x55	8x50	ccr_on	0	100	No	No	No	Yes	7	8
339	1x57	2x43	ccr_on	0	100	No	Yes	No	No	7	8
340	1x57	2x44	ccr_on	0	100	No	Yes	No	No	7	6
341	2x38	I2x57	ccr_on	0	100	Yes	Yes	No	Yes	6	7
342	2x46	2x50	ccr_on	0	100	No	No	No	Yes	9	9
343	2x49	4x50	ccr_on	0	100	No	No	Yes	Yes	8	9
344	2x50	7x46	ccr_on	0	100	No	Yes	No	No	9	8
345	2x52	3x31	ccr_on	0	100	No	No	No	No	7	4
346	2x57	7x42	ccr_on	0	100	No	Yes	Yes	Yes	7	7
347	2x60	2x63	ccr_on	0	100	Yes	Yes	No	No	6	4
348	2x63	Lig	ccr_on	0	100	No	No	Yes	Yes	4	0
349	3x37	5x42	ccr_on	0	100	Yes	Yes	No	No	7	4
350	5x38	5x42	ccr_on	0	100	No	No	No	No	4	4
351	5x62	6x34	ccr_on	0	100	No	No	No	Yes	4	6
352	7x27	Lig	ccr_on	0	100	No	No	Yes	Yes	2	0
353	3x32	7x38	ccr_on	0	100	No	Yes	No	Yes	6	5
354	3x37	5x43	ccr_on	0	100	Yes	Yes	No	No	7	5
355	6x56	6x60	ccr_on	0	100	No	No	No	Yes	6	4
356	1x59	8x53	ccr_on	0	100	No	Yes	No	Yes	4	5
357	7x25	7x26	ccr_on	0	20	No	No	No	No	0	1
358	4x38	4x41	ccr_on	0	20	No	No	No	No	7	4
359	5x31	5x35	ccr_on	0	40	No	No	Yes	Yes	0	3
360	E1x51	E1x52	ccr_on	0	60	No	No	No	Yes	3	7
361	1x24	7x28	ccr_on	0	40	No	No	No	No	0	3
362	1x52	7x55	ccr_on	0	50	No	No	No	No	6	7
363	3x48	5x53	ccr_on	0	40	No	No	No	No	6	6
364	I1x48	I1x51	ccr_on	0	60	No	No	No	No	6	6
365	1x43	2x57	ccr_on	0	40	No	No	No	Yes	7	7
366	2x37	I2x57	ccr_on	0	40	No	No	No	Yes	7	7
367	1x27	7x28	ccr_on	0	50	No	No	No	No	5	3
368	6x64	E3	ccr_on	0	40	No	No	Yes	No	1	0
369	3x56	I2x52	ccr_on	0	30	No	No	No	No	6	4
370	1x57	8x50	ccr_on	0	20	No	Yes	No	Yes	7	8
371	6x43	6x47	ccr_on	0	66.6667	No	No	Yes	Yes	6	8
372	6x27	6x30	ccr_on	0	40	No	No	No	Yes	1	5
373	3x54	5x64	ccr_on	0	46.6667	No	No	No	No	8	5
374	1x46	7x47	ccr_on	0	46.6667	No	No	No	No	8	8
375	8x48	8x52	ccr_on	0	36.6667	No	No	No	No	5	4
376	5x56	5x60	ccr_on	0	40	No	No	No	No	4	4
377	I2x52	I2x55	ccr_on	0	60	No	No	No	No	4	4
378	6x34	6x38	ccr_on	0	10	No	Yes	No	No	6	4
379	3x39	7x45	ccr_on	0	40	No	No	No	Yes	9	9
380	1x54	2x47	ccr_on	0	0	No	No	No	No	8	9
381	6x30	6x31	ccr_on	0	20	No	Yes	No	No	5	4
382	I1x49	I1x50	ccr_on	0	40	No	No	No	No	6	6
383	2x54	2x57	ccr_on	0	20	No	No	No	Yes	6	7
384	5x33	6x62	ccr_on	0	20	No	No	No	No	3	3
385	I2x53	I2x57	ccr_on	0	0	No	No	No	Yes	5	7
386	1x57	2x40	ccr_on	0	36.6667	No	Yes	No	No	7	8
387	5x33	Lig	ccr_on	0	26.6667	No	No	Yes	Yes	3	0
388	1x30	7x32	ccr_on	0	40	No	No	No	No	4	1
389	8x53	8x60	ccr_on	0	20	No	Yes	No	No	5	0
390	5x65	6x33	ccr_on	0	0	No	No	No	No	8	7
391	1x27	NT	ccr_on	0	40	No	No	Yes	Yes	5	0
392	6x61	7x30	ccr_on	0	40	No	No	No	Yes	4	4
393	6x32	6x35	ccr_on	0	30	No	No	No	No	6	5
394	6x31	I3	ccr_on	0	20	No	No	No	No	4	0
395	6x26	6x29	ccr_on	0	20	No	No	No	No	0	4
396	3x38	4x53	ccr_on	0	20	No	No	No	No	7	8
397	6x36	6x40	ccr_on	0	30	No	No	Yes	No	8	8
398	1x31	7x35	ccr_on	0	40	No	No	No	No	3	4
399	6x60	6x63	ccr_on	0	20	No	Yes	No	No	4	1
400	8x49	8x53	ccr_on	0	20	No	No	No	Yes	6	5
401	1x42	2x57	ccr_on	0	20	No	No	No	Yes	7	7
402	I1x49	I1x51	ccr_on	0	20	No	No	No	No	6	6
403	2x38	I2	ccr_on	0	20	Yes	Yes	No	No	6	0
404	6x32	6x36	ccr_on	0	6.66667	No	No	No	No	6	8
405	6x28	6x29	ccr_on	0	30	No	No	No	No	3	4
406	8x56	8x60	ccr_on	0	20	No	No	No	No	4	0
407	7x25	7x29	ccr_on	0	20	No	No	No	No	0	3
408	1x29	1x30	ccr_on	0	20	No	No	No	No	4	4
409	5x41	6x59	ccr_on	0	20	No	No	No	No	4	5
410	3x52	I2x53	ccr_on	0	30	No	No	No	No	5	5
411	5x55	6x41	ccr_on	0	20	No	No	No	No	4	8
412	1x45	7x47	ccr_on	0	20	No	No	No	No	6	8
413	1x25	1x28	ccr_on	0	40	No	No	No	No	0	5
414	3x27	3x31	ccr_on	0	13.3333	No	No	No	No	4	4
415	4x57	4x62	ccr_on	0	0	No	No	No	No	7	5
416	6x65	7x30	ccr_on	0	20	No	No	No	Yes	0	4
417	2x67	Lig	ccr_on	0	20	No	No	Yes	Yes	0	0
418	5x55	5x59	ccr_on	0	0	No	No	No	No	4	4
419	6x65	7x23	ccr_on	0	20	No	No	No	No	0	0
420	1x33	1x34	ccr_on	0	10	No	No	No	No	5	5
421	5x65	6x30	ccr_on	0	26.6667	No	No	No	Yes	8	5
422	6x45	6x46	ccr_on	0	20	Yes	No	No	No	5	6
423	2x55	2x59	ccr_on	0	20	No	No	No	No	4	6
424	5x47	5x48	ccr_on	0	20	No	Yes	No	No	8	5
425	5x64	5x67	ccr_on	0	6.66667	No	No	No	No	5	5
426	3x21	3x24	ccr_on	0	0	No	No	No	No	7	5
427	5x66	6x34	ccr_on	0	0	No	No	No	Yes	4	6
428	1x26	7x28	ccr_on	0	20	No	No	No	No	0	3
429	1x32	2x64	ccr_on	0	20	No	No	No	No	7	5
430	6x32	8x51	ccr_on	0	20	No	No	No	No	6	8
431	4x59	4x63	ccr_on	0	20	No	No	No	No	5	5
432	5x68	6x30	ccr_on	0	16.6667	No	No	No	Yes	0	5
433	6x39	6x43	ccr_on	0	0	No	No	No	No	5	6
434	1x40	2x61	ccr_on	0	0	No	No	No	No	3	7
435	7x36	7x37	ccr_on	0	0	No	No	No	Yes	5	7
436	8x60	8x61	ccr_on	0	20	No	No	No	No	0	0
437	4x43	4x47	ccr_on	0	0	No	No	No	No	4	4
438	8x57	CT	ccr_on	0	0	No	No	No	No	5	4
439	8x58	8x59	ccr_on	0	0	No	No	No	No	6	0
440	3x23	3x27	ccr_on	0	0	No	No	No	No	3	4
441	8x55	8x56	ccr_on	0	0	No	No	No	No	5	4

Orange: nodes, hubs and links specific of ccr_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of ccr_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	ccr_off Avg Int. Strength	ccr_on Avg Int. Strength	ccr_off Num Of Links	ccr_on Num Of Links	ConSurf
1	1x35	ccr_off	50	20	5	3	6
2	1x60	ccr_off	0	20	5	1	5
3	3x28	ccr_off	0	20	4	2	6
4	3x33	ccr_off	50	20	4	3	5
5	3x41	ccr_off	0	0	4	3	5
6	4x64	ccr_off	50	0	4	3	4
7	6x40	ccr_off	50	0	4	2	8
8	6x45	ccr_off	50	0	4	2	5
9	6x51	ccr_off	100	20	4	3	6
10	E3	ccr_off	50	40	4	3	0
11	1x39	Shared	50	20	5	5	7
12	2x38	Shared	0	0	4	4	6
13	2x42	Shared	100	100	4	6	7
14	2x60	Shared	100	20	4	4	6
15	E1x50	Shared	100	100	7	5	8
16	3x36	Shared	50	30	4	4	7
17	3x37	Shared	100	60	4	4	7
18	3x42	Shared	100	80	4	4	7
19	3x51	Shared	50	20	5	4	8
20	4x50	Shared	50	50	5	4	9
21	E2	Shared	100	100	14	13	3
22	5x35	Shared	50	20	4	4	3
23	5x50	Shared	0	20	5	4	8
24	5x58	Shared	0	100	5	6	8
25	6x44	Shared	100	50	5	4	9
26	6x47	Shared	0	20	4	5	8
27	6x48	Shared	100	100	5	5	9
28	7x42	Shared	50	90	4	4	7
29	7x53	Shared	50	90	5	5	9
30	Lig	Shared	100	100	24	21	0
31	NT	Shared	50	80	4	5	0
32	1x57	ccr_on	0	20	1	4	7
33	1x59	ccr_on	0	0	3	4	4
34	2x50	ccr_on	0	20	2	4	9
35	2x53	ccr_on	0	63.3333	3	4	6
36	2x57	ccr_on	0	13.3333	1	5	7
37	E1x52	ccr_on	0	20	3	5	7
38	3x32	ccr_on	100	30	3	5	6
39	3x49	ccr_on	0	30	3	4	8
40	E2x52	ccr_on	0	0	2	4	4
41	5x47	ccr_on	0	20	2	4	8
42	6x30	ccr_on	0	0	2	4	5
43	6x34	ccr_on	0	0	1	4	6
44	6x49	ccr_on	0	20	2	4	5
45	6x60	ccr_on	0	0	3	4	4
46	7x30	ccr_on	0	0	1	4	4
47	7x37	ccr_on	0	0	3	4	7
48	7x38	ccr_on	0	20	3	4	5
49	7x45	ccr_on	50	80	3	5	9
50	7x49	ccr_on	0	50	2	4	9
51	8x50	ccr_on	50	53.3333	3	5	8
52	8x53	ccr_on	0	0	3	5	5
53	I2x57	ccr_on	0	30	3	5	7

Orange: nodes, hubs and links specific of ccr_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of ccr_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	ccr_off Recurrence	ccr_on Recurrence	ccr_off Hub1?	ccr_on Hub1?	ccr_off Hub2?	ccr_on Hub2?	ConSurf1	ConSurf2
1	1x35	Lig	ccr_off	17.5691	0	Yes	No	Yes	Yes	6	0
2	2x54	7x46	ccr_off	10.6397	0	No	No	No	No	6	8
3	6x48	6x51	ccr_off	56.2487	0	Yes	Yes	Yes	No	9	6
4	6x48	7x45	ccr_off	12.3286	8.40668	Yes	Yes	No	Yes	9	9
5	6x47	7x45	ccr_off	19.2477	6.39216	Yes	Yes	No	Yes	8	9
6	6x44	6x48	ccr_off	40.7062	1.1287	Yes	Yes	Yes	Yes	9	9
7	6x44	6x45	ccr_off	71.0594	0	Yes	Yes	Yes	No	9	5
8	6x41	6x45	ccr_off	61.1105	0	No	No	Yes	No	8	5
9	3x43	6x41	ccr_off	38.2037	0	No	No	No	No	8	8
10	3x43	6x40	ccr_off	35.7677	0	No	No	Yes	No	8	8
11	6x40	7x49	ccr_off	17.3132	0	Yes	No	No	Yes	8	9
12	1x50	2x50	ccr_off	14.5292	5.34061	No	No	No	Yes	9	9
13	3x32	3x33	ccr_off	56.868	7.31798	No	Yes	Yes	No	6	5
14	3x33	3x37	ccr_off	74.8874	0	Yes	No	Yes	Yes	5	7
15	3x37	5x46	ccr_off	100	0	Yes	Yes	No	No	7	4
16	3x41	5x46	ccr_off	98.0246	1.07441	Yes	No	No	No	5	4
17	3x41	4x49	ccr_off	89.6469	5.32632	Yes	No	No	No	5	7
18	3x42	4x49	ccr_off	32.7482	7.41799	Yes	Yes	No	No	7	7
19	3x42	4x50	ccr_off	28.0092	4.26049	Yes	Yes	Yes	Yes	7	9
20	2x48	4x50	ccr_off	18.5722	0	No	No	Yes	Yes	5	9
21	2x44	2x48	ccr_off	16.9345	1.76592	No	No	No	No	6	5
22	2x38	3x49	ccr_off	54.0839	0.00285747	Yes	Yes	No	Yes	6	8
23	2x39	3x49	ccr_off	45.6192	0.93725	No	No	No	Yes	7	8
24	2x37	2x39	ccr_off	28.4289	0	No	No	No	No	7	7
25	1x56	8x53	ccr_off	10.2354	0	No	No	No	Yes	7	5
26	1x60	8x53	ccr_off	11.2692	1.75163	Yes	No	No	Yes	5	5
27	6x40	7x53	ccr_off	10.5578	0	Yes	No	Yes	Yes	8	9
28	2x60	Lig	ccr_off	19.1914	2.1231	Yes	Yes	Yes	Yes	6	0
29	2x60	E1x50	ccr_off	11.3715	0	Yes	Yes	Yes	Yes	6	8
30	3x33	4x61	ccr_off	18.8639	1.06012	Yes	No	No	No	5	4
31	3x36	3x37	ccr_off	58.4852	4.28335	Yes	Yes	Yes	Yes	7	7
32	3x36	6x48	ccr_off	14.4831	6.39216	Yes	Yes	Yes	Yes	7	9
33	3x36	5x43	ccr_off	17.4872	1.06869	Yes	Yes	No	No	7	5
34	3x40	6x44	ccr_off	10.9058	0	No	No	Yes	Yes	8	9
35	5x50	6x45	ccr_off	11.8936	0	Yes	Yes	Yes	No	8	5
36	3x44	5x50	ccr_off	13.2753	3.22037	No	No	Yes	Yes	8	8
37	5x54	6x41	ccr_off	27.7892	0	No	No	No	No	8	8
38	5x54	5x58	ccr_off	26.4841	2.89747	No	No	Yes	Yes	8	8
39	2x39	3x50	ccr_off	17.6049	0	No	No	No	No	7	9
40	5x58	5x61	ccr_off	18.4289	4.27192	Yes	Yes	No	No	8	8
41	3x51	5x61	ccr_off	11.7042	0	Yes	Yes	No	No	8	8
42	5x43	6x52	ccr_off	15.3634	0	No	No	No	No	5	8
43	E3	Lig	ccr_off	14.1607	5.00057	Yes	No	Yes	Yes	0	0
44	5x39	E2	ccr_off	16.0952	1.00583	No	No	Yes	Yes	5	3
45	4x61	5x39	ccr_off	17.8813	0	No	No	No	No	4	5
46	3x36	6x44	ccr_off	43.2753	0	Yes	Yes	Yes	Yes	7	9
47	3x32	Lig	Shared	51.1566	45.2166	No	Yes	Yes	Yes	6	0
48	2x53	3x32	Shared	12.1955	73.4427	No	Yes	No	Yes	6	6
49	2x53	7x46	Shared	12.738	99.9657	No	Yes	No	No	6	8
50	7x38	Lig	Shared	47.5947	10.4841	No	Yes	Yes	Yes	5	0
51	6x51	7x38	Shared	48.1679	34.6154	Yes	No	No	Yes	6	5
52	2x50	7x49	Shared	15.9263	99.0742	No	Yes	No	Yes	9	9
53	3x45	4x49	Shared	65.2047	13.5558	No	No	No	No	6	7
54	2x42	3x45	Shared	63.9406	14.5588	Yes	Yes	No	No	7	6
55	2x38	2x42	Shared	59.2272	36.2584	Yes	Yes	Yes	Yes	6	7
56	2x37	2x40	Shared	26.868	62.7215	No	No	No	No	7	8
57	2x40	I1x48	Shared	23.7001	36.3327	No	No	No	No	8	6
58	8x53	I1x48	Shared	22.4053	19.5737	No	Yes	No	No	5	6
59	E1x50	E1x52	Shared	13.1013	24.7143	Yes	Yes	No	Yes	8	7
60	E2	Lig	Shared	35.911	22.9541	Yes	Yes	Yes	Yes	3	0
61	E1x50	E2	Shared	15.3019	12.2414	Yes	Yes	Yes	Yes	8	3
62	Lig	NT	ccr_on	9.52405	10.3983	Yes	Yes	Yes	Yes	0	0
63	7x38	7x42	ccr_on	0	20.4223	No	Yes	Yes	Yes	5	7
64	2x57	7x42	ccr_on	0	11.587	No	Yes	Yes	Yes	7	7
65	2x50	7x46	ccr_on	0	100	No	Yes	No	No	9	8
66	1x57	8x50	ccr_on	0	16.5933	No	Yes	No	Yes	7	8
67	1x57	2x40	ccr_on	0	26.8002	No	Yes	No	No	7	8
68	2x37	I2x57	ccr_on	0	64.2502	No	No	No	Yes	7	7
69	2x38	I2x57	ccr_on	0	34.9268	Yes	Yes	No	Yes	6	7
70	2x42	3x46	ccr_on	0	82.7752	Yes	Yes	No	No	7	9
71	3x46	7x53	ccr_on	0	83.1152	No	No	Yes	Yes	9	9
72	7x49	7x53	ccr_on	0	93.425	No	Yes	Yes	Yes	9	9
73	3x49	I2x57	ccr_on	8.51586	35.1383	No	Yes	No	Yes	8	7
74	2x42	3x49	ccr_on	0	36.5613	Yes	Yes	No	Yes	7	8
75	2x63	E1x50	ccr_on	0.138178	19.6851	No	No	Yes	Yes	4	8
76	2x63	Lig	ccr_on	0	12.5214	No	No	Yes	Yes	4	0
77	7x45	7x49	ccr_on	0	22.334	No	Yes	No	Yes	9	9
78	3x47	5x58	ccr_on	1.49437	12.5471	No	No	Yes	Yes	9	8
79	3x50	5x58	ccr_on	0	31.5808	No	No	Yes	Yes	9	8
80	3x50	7x53	ccr_on	0	32.2723	No	No	Yes	Yes	9	9
81	3x47	5x57	ccr_on	0	11.5327	No	No	No	No	9	7
82	3x51	5x57	ccr_on	1.49437	10.5126	Yes	Yes	No	No	8	7
83	6x56	6x60	ccr_on	0	12.6786	No	No	No	Yes	6	4
84	5x44	6x56	ccr_on	2.22108	14.4674	No	No	No	No	5	6
85	5x44	6x52	ccr_on	6.64278	16.2504	No	No	No	No	5	8
86	5x47	6x52	ccr_on	6.64278	18.0278	No	Yes	No	No	8	8
87	5x47	6x49	ccr_on	4.43705	23.3255	No	Yes	No	Yes	8	5
88	6x49	6x50	ccr_on	0	32.0408	No	Yes	No	No	5	9
89	6x50	7x37	ccr_on	2.19038	33.7667	No	No	No	Yes	9	7
90	6x51	7x37	ccr_on	6.29478	31.7465	Yes	No	No	Yes	6	7
91	5x58	6x37	ccr_on	1.48414	15.2303	Yes	Yes	No	No	8	7
92	5x62	6x37	ccr_on	0	14.2331	No	No	No	No	4	7
93	5x65	6x34	ccr_on	1.23337	10.1869	No	No	No	Yes	8	6
94	5x62	6x34	ccr_on	0	13.2301	No	No	No	Yes	4	6
95	7x52	7x53	ccr_on	0	10.2069	No	No	Yes	Yes	8	9
96	I1x48	I1x51	ccr_on	0	15.7104	No	No	No	No	6	6
97	I1x49	I1x51	ccr_on	0	13.9873	No	No	No	No	6	6
98	I1x49	I1x50	ccr_on	0	12.2585	No	No	No	No	6	6
99	2x41	I1x50	ccr_on	5.18424	10.5241	No	No	No	No	7	6
100	2x53	7x42	ccr_on	6.39202	27.8746	No	Yes	Yes	Yes	6	7
101	3x32	7x38	ccr_on	0	15.256	No	Yes	No	Yes	6	5
102	2x60	3x32	ccr_on	0	12.7986	Yes	Yes	No	Yes	6	6

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
1x31	Lig	ccr_off	5.46	0	0	0	1	0
1x35	1x39	Shared	12.895	9.15933	1	0	1	2
1x35	7x39	ccr_off	5.16	0	1	0	1	2
1x35	Lig	ccr_off	6.955	0	1	0	1	0
1x39	2x57	Shared	5.41	4.933	1	1	2	2
1x39	7x39	Shared	8.74	3.01067	1	1	2	2
1x39	7x42	Shared	13.17	5.53833	1	1	2	1
2x53	3x32	Shared	9.8	10.5903	0	0	2	1
2x53	7x42	Shared	4.98	7.77833	0	0	2	1
2x56	2x60	Shared	8.49	3.154	0	0	2	1
2x60	E1x50	ccr_off	5.625	0	1	1	1	2
2x60	7x42	ccr_off	4.65	0	1	1	1	1
2x60	Lig	Shared	22.085	13.2927	1	1	1	0
2x63	E1x50	Shared	7.915	7.40967	1	1	1	2
E1x49	E2	Shared	13.19	4.68967	1	0	2	1
E1x50	E2	Shared	4.805	5.279	1	1	2	1
3x22	3x26	Shared	6.02	5.076	1	1	2	2
3x22	E2	Shared	14.115	5.34	1	1	2	1
3x26	E2	ccr_off	5.34	0	1	0	2	1
3x29	4x65	Shared	12.56	10.6637	1	1	1	1
3x29	Lig	Shared	7.925	4.483	1	1	1	0
3x32	3x33	Shared	8.48	5.87267	1	1	1	2
3x32	Lig	Shared	10.845	6.49533	1	1	1	0
4x64	E2	Shared	14.845	12.7007	1	1	2	1
4x64	5x32	ccr_off	4.335	0	1	1	2	1
4x64	5x35	Shared	14.53	6.24667	1	1	2	2
4x65	Lig	ccr_off	3.94	0	1	0	1	0
E2	E2	Shared	60.935	54.4367	1	1	1	1
E2	E2x52	Shared	4.75	3.39067	1	1	1	1
5x35	E2	Shared	6.06	7.397	1	1	2	1
5x36	E2	Shared	5.515	4.332	1	0	2	1
5x39	E2	Shared	4.02	5.813	1	0	2	1
5x33	5x37	ccr_off	10.16	0	0	1	1	2
5x40	6x55	ccr_off	4.49	0	1	0	1	2
5x40	6x59	Shared	14.13	7.186	1	0	1	2
6x51	6x55	Shared	10.09	8.897	0	0	2	2
6x51	7x37	Shared	5.615	6.046	0	0	2	2
6x51	7x38	Shared	7.855	8.374	0	0	2	1
6x54	7x34	Shared	3.9	3.575	0	0	2	1
6x54	7x37	Shared	5.555	6.64067	0	0	2	2
6x58	7x30	Shared	4.805	2.52333	0	0	2	2
6x58	7x34	ccr_off	5	0	0	0	2	1
6x61	7x27	ccr_off	4.97	0	1	1	1	1
7x35	Lig	Shared	14.545	3.77767	1	1	1	0
7x38	Lig	Shared	12.48	4.933	1	1	1	0
7x42	Lig	ccr_off	4.235	0	1	1	1	0
E2x52	Lig	Shared	8.385	3.998	1	1	1	0
E2	Lig	Shared	39.86	52.2837	1	1	1	0
5x40	Lig	ccr_off	3.94	0	1	0	1	0
E2x51	Lig	Shared	9.025	6.25667	0	1	1	0
1x24	Lig	ccr_off	4.425	0	1	0	1	0
7x31	Lig	Shared	5.61	5.52133	0	0	1	0
7x34	Lig	Shared	3.94	5.59433	1	1	1	0
Lig	NT	Shared	19.49	49.1893	1	1	0	1
6x61	Lig	Shared	5.64	4.106	1	1	1	0
5x32	Lig	Shared	11.885	7.195	1	1	1	0
1x24	1x27	ccr_off	9.865	0	1	0	1	2
2x63	E2	ccr_off	5.76	0	1	1	1	1
5x31	E2	ccr_off	4.47	0	0	0	2	1
5x32	5x36	ccr_off	4.18	0	1	1	1	2
6x62	E3	ccr_off	6.575	0	0	0	2	1
7x35	7x38	ccr_off	5.735	0	1	1	1	1
7x24	NT	Shared	3.64	4.48933	0	0	2	1
E3	Lig	Shared	3.585	5.47133	1	1	1	0
1x35	2x64	Shared	3.15	3.83233	1	0	1	2
7x28	NT	ccr_off	2.36	0	0	0	2	1
1x28	Lig	Shared	2.115	6.817	0	1	1	0
1x34	1x35	ccr_off	2.075	0	0	0	2	1
7x26	E3	Shared	1.5	5.35533	0	0	2	1
7x36	Lig	ccr_off	1.35	0	0	0	1	0
6x65	E3	ccr_off	0.85	0	0	0	2	1
1x25	NT	ccr_off	0.685	0	0	0	2	1
NT	NT	ccr_on	0	11.1183	1	1	1	1
1x35	7x35	ccr_on	0	4.98867	1	0	1	1
2x60	3x32	ccr_on	0	3.663	1	1	1	1
4x65	E2x52	ccr_on	0	3.48667	1	0	1	1
E2	E2x51	ccr_on	0	7.15767	1	1	1	1
E2x51	E2x52	ccr_on	0	3.60533	0	1	1	1
5x32	E2	ccr_on	0	3.76967	1	1	1	1
7x38	7x42	ccr_on	0	5.01167	1	1	1	1
2x57	7x42	ccr_on	0	7.20933	0	1	2	1
2x60	2x63	ccr_on	0	3.325	1	1	1	1
2x63	Lig	ccr_on	0	6.53067	1	1	1	0
7x27	Lig	ccr_on	0	3.64	0	0	1	0
3x32	7x38	ccr_on	0	3.89	1	1	1	1
5x31	5x35	ccr_on	0	3.125	0	0	2	2
1x24	7x28	ccr_on	0	3.024	1	0	1	2
1x27	7x28	ccr_on	0	2.865	0	1	2	2
6x64	E3	ccr_on	0	2.82467	0	0	2	1
5x33	6x62	ccr_on	0	2.233	0	1	1	2
5x33	Lig	ccr_on	0	2.17867	0	1	1	0
1x27	NT	ccr_on	0	2.046	0	1	2	1
6x61	7x30	ccr_on	0	2.03333	1	1	1	2
1x31	7x35	ccr_on	0	1.896	0	0	1	1
1x25	1x28	ccr_on	0	1.484	0	0	2	1
6x65	7x30	ccr_on	0	1.462	0	0	2	2
2x67	Lig	ccr_on	0	1.434	0	0	1	0
7x36	7x37	ccr_on	0	0.689	0	0	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	ccr_off	ccr2_off ccr5_off
	ccr_on	ccr6_on ccr8_on ccr2_on ccr1_on ccr5_on

Network Difference
Value	ccr_off	ccr_on
I_min	3.89	3.166
Number of Linked Nodes	273	281
Number of Specific Nodes	2 (0.73%)	10 (3.56%)
Number of Shared Nodes	271 (99.27%)	271 (96.44%)
Number of Links	300	311
Number of Specific Links	130 (43.33%)	141 (45.34%)
Number of Shared Links	170 (56.67%)	170 (54.66%)
Number of Hubs	31	43
Number of Specific Hubs	10 (32.26%)	22 (51.16%)
Number of Shared Hubs	21 (67.74%)	21 (48.84%)
Average % Shared Neighbours (Jaccard)	41.13
Average % Shared Neighbours (Otsuka)	50.49
Average % Shared Neighbours (Overlap Coefficient)	60.35
Average % Shared Cliques (k3-6)	56.25
Graphlets Similarity	0.579961

Paths Difference
Value	ccr_off	ccr_on
Number Of Nodes in MetaPath	58	53
Specific Nodes in MetaPath	31 (53.45%)	26 (49.06%)
Shared Nodes in MetaPath	271 (99.27%)	271 (99.27%)
Number Of Links MetaPath	61	56
Specific Links in MetaPath	46 (75.41%)	41 (73.21%)
Shared Links in MetaPath	170 (56.67%)	170 (56.67%)
Number of Shortest Paths	47722	62949
Length Of Smallest Path	3	3
Average Path Length	12.3819	14.2602
Length of Longest Path	31	35
Minimum Path Strength	0.77	0.407
Average Path Strength	7.15325	5.83929
Maximum Path Strength	27.3525	38.0579
Minimum Path Correlation	0.7	0.7
Average Path Correlation	0.916277	0.931439
Maximum Path Correlation	0.99	0.988667
Minimum % Of Corr. Nodes	3.57143	3.84615
Average % Of Corr. Nodes	47.8683	50.8317
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	43.2585	51.9632
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

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