psnGPCR

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Orange: nodes, hubs and links specific of chemokine_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of chemokine_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	chemokine_off Int. Strength	chemokine_on Int. Strength	chemokine_off Hub1?	chemokine_on Hub1?	chemokine_off Hub2?	chemokine_on Hub2?	ConSurf1	ConSurf2
1	1x35	Lig	chemokine_off	100	0	Yes	Yes	Yes	Yes	6	0
2	1x39	Lig	chemokine_off	100	0	Yes	Yes	Yes	Yes	7	0
3	2x40	I1x48	chemokine_off	100	0	Yes	No	No	No	8	6
4	2x39	3x50	chemokine_off	100	0	No	No	Yes	No	7	9
5	2x43	7x53	chemokine_off	100	0	No	No	Yes	Yes	8	9
6	2x56	3x28	chemokine_off	100	0	No	No	No	No	7	6
7	2x60	E1x50	chemokine_off	100	0	Yes	No	Yes	Yes	6	8
8	2x60	7x42	chemokine_off	100	0	Yes	No	Yes	Yes	6	7
9	3x26	E2	chemokine_off	100	0	No	No	Yes	Yes	7	3
10	3x29	Lig	chemokine_off	100	0	No	No	Yes	Yes	6	0
11	3x32	7x42	chemokine_off	100	0	Yes	Yes	Yes	Yes	6	7
12	3x33	3x37	chemokine_off	100	0	Yes	No	Yes	Yes	5	7
13	3x36	5x43	chemokine_off	100	0	No	No	No	No	7	5
14	3x37	5x46	chemokine_off	100	0	Yes	Yes	No	No	7	4
15	3x40	5x50	chemokine_off	100	0	No	No	Yes	Yes	8	8
16	3x40	6x44	chemokine_off	100	0	No	No	Yes	No	8	9
17	3x43	6x41	chemokine_off	100	0	Yes	No	No	No	8	8
18	3x46	6x37	chemokine_off	100	0	No	No	No	No	9	7
19	3x50	6x33	chemokine_off	100	0	Yes	No	No	No	9	7
20	4x61	5x39	chemokine_off	100	0	No	No	No	No	4	5
21	5x36	E2	chemokine_off	100	0	No	No	Yes	Yes	3	3
22	5x33	5x37	chemokine_off	100	0	No	No	No	No	3	3
23	5x37	6x60	chemokine_off	100	0	No	No	No	No	3	4
24	5x43	6x52	chemokine_off	100	0	No	No	No	No	5	8
25	5x44	6x56	chemokine_off	100	0	No	No	No	No	5	6
26	5x54	6x41	chemokine_off	100	0	No	No	No	No	8	8
27	5x58	6x38	chemokine_off	100	0	Yes	Yes	No	No	8	4
28	6x29	6x33	chemokine_off	100	0	No	No	No	No	4	7
29	6x32	8x48	chemokine_off	100	0	No	No	Yes	No	6	5
30	6x38	6x42	chemokine_off	100	0	No	No	No	No	4	5
31	6x41	6x45	chemokine_off	100	0	No	No	No	No	8	5
32	6x44	6x45	chemokine_off	100	0	Yes	No	No	No	9	5
33	6x44	7x45	chemokine_off	100	0	Yes	No	No	Yes	9	9
34	6x47	7x48	chemokine_off	100	0	No	No	No	No	8	6
35	6x48	6x51	chemokine_off	100	0	Yes	Yes	Yes	No	9	6
36	6x54	7x34	chemokine_off	100	0	No	No	No	No	5	4
37	6x58	7x34	chemokine_off	100	0	No	No	No	No	4	4
38	6x59	6x60	chemokine_off	100	0	No	No	No	No	5	4
39	7x42	Lig	chemokine_off	100	0	Yes	Yes	Yes	Yes	7	0
40	E2x52	Lig	chemokine_off	100	0	Yes	No	Yes	Yes	4	0
41	5x40	Lig	chemokine_off	100	0	No	No	Yes	Yes	5	0
42	1x24	Lig	chemokine_off	100	0	No	No	Yes	Yes	0	0
43	1x24	1x27	chemokine_off	100	0	No	No	No	No	0	5
44	E1x49	E1x51	chemokine_off	100	0	No	No	No	No	4	3
45	3x43	6x44	chemokine_off	100	0	Yes	No	Yes	No	8	9
46	6x62	E3	chemokine_off	100	0	No	No	Yes	Yes	3	0
47	7x53	8x50	chemokine_off	100	0	Yes	Yes	Yes	Yes	9	8
48	3x41	5x50	chemokine_off	100	0	Yes	No	Yes	Yes	5	8
49	2x37	2x39	chemokine_off	50	0	No	No	No	No	7	7
50	6x63	6x64	chemokine_off	50	0	No	No	No	No	1	1
51	3x50	3x53	chemokine_off	75	0	Yes	No	No	No	9	8
52	3x43	6x40	chemokine_off	50	0	Yes	No	No	Yes	8	8
53	6x36	7x53	chemokine_off	50	0	No	No	Yes	Yes	8	9
54	4x38	4x42	chemokine_off	50	0	No	No	Yes	No	7	7
55	6x62	6x63	chemokine_off	50	0	No	No	No	No	3	1
56	1x53	7x53	chemokine_off	58.3333	0	No	No	Yes	Yes	9	9
57	2x52	3x31	chemokine_off	50	0	No	No	No	No	7	4
58	2x54	7x46	chemokine_off	66.6667	0	No	No	No	No	6	8
59	5x51	6x45	chemokine_off	50	0	No	No	No	No	6	5
60	5x35	5x38	chemokine_off	50	0	Yes	No	No	No	3	4
61	1x58	1x59	chemokine_off	50	0	No	No	No	Yes	3	4
62	2x49	4x50	chemokine_off	58.3333	0	No	No	Yes	No	8	9
63	3x48	3x52	chemokine_off	50	0	No	No	Yes	No	6	5
64	3x51	3x52	chemokine_off	50	0	Yes	Yes	Yes	No	8	5
65	3x51	5x61	chemokine_off	50	0	Yes	Yes	Yes	No	8	8
66	1x36	2x64	chemokine_off	25	0	No	No	No	No	5	5
67	2x44	I1x50	chemokine_off	50	0	Yes	No	No	No	6	6
68	1x31	Lig	chemokine_off	50	0	No	No	Yes	Yes	3	0
69	6x29	8x48	chemokine_off	50	0	No	No	Yes	No	4	5
70	1x42	7x47	chemokine_off	50	0	No	No	No	No	7	8
71	1x56	8x53	chemokine_off	50	0	No	No	No	Yes	7	5
72	6x28	6x31	chemokine_off	50	0	No	No	No	No	3	4
73	6x35	7x56	chemokine_off	50	0	No	No	No	No	5	6
74	6x57	6x64	chemokine_off	50	0	No	No	No	No	4	1
75	1x51	2x51	chemokine_off	50	0	No	No	No	No	4	7
76	1x25	1x29	chemokine_off	50	0	No	No	No	No	0	4
77	3x50	6x30	chemokine_off	50	0	Yes	No	No	Yes	9	5
78	7x23	7x25	chemokine_off	50	0	No	No	No	No	0	0
79	6x39	7x56	chemokine_off	50	0	No	No	No	No	5	6
80	5x39	5x42	chemokine_off	33.3333	0	No	No	No	No	5	4
81	1x24	7x28	chemokine_off	50	0	No	No	No	No	0	3
82	3x49	I2x54	chemokine_off	50	0	No	Yes	No	No	8	5
83	1x38	1x42	chemokine_off	50	0	No	No	No	No	5	7
84	5x31	E2	chemokine_off	50	0	No	No	Yes	Yes	0	3
85	3x52	I2x51	chemokine_off	50	0	Yes	No	No	No	5	5
86	1x38	1x39	chemokine_off	25	0	No	No	Yes	Yes	5	7
87	2x48	4x50	chemokine_off	0	0	No	No	Yes	No	5	9
88	3x54	6x31	chemokine_off	50	0	No	No	No	No	8	4
89	3x39	6x44	chemokine_off	50	0	No	No	Yes	No	9	9
90	1x56	8x54	chemokine_off	50	0	No	No	Yes	No	7	7
91	3x21	E1x50	chemokine_off	0	0	No	No	Yes	Yes	7	8
92	6x47	7x40	chemokine_off	25	0	No	No	No	No	8	7
93	1x60	8x57	chemokine_off	25	0	Yes	No	No	No	5	5
94	3x41	4x53	chemokine_off	0	0	Yes	No	No	No	5	8
95	5x61	6x34	chemokine_off	0	0	Yes	No	No	No	8	6
96	1x34	1x35	chemokine_off	33.3333	0	No	No	Yes	Yes	5	6
97	1x60	8x56	chemokine_off	0	0	Yes	No	No	No	5	4
98	3x45	4x40	chemokine_off	50	0	No	No	No	No	6	4
99	1x60	CT	chemokine_off	25	0	Yes	No	No	No	5	4
100	5x45	5x48	chemokine_off	50	0	No	No	No	No	4	5
101	7x53	8x49	chemokine_off	25	0	Yes	Yes	No	No	9	6
102	5x62	5x66	chemokine_off	25	0	No	No	No	No	4	4
103	6x27	6x28	chemokine_off	25	0	No	No	No	No	1	3
104	8x55	8x59	chemokine_off	25	0	No	No	No	No	5	0
105	5x58	5x62	chemokine_off	25	0	Yes	Yes	No	No	8	4
106	5x44	5x48	chemokine_off	0	0	No	No	No	No	5	5
107	1x25	NT	chemokine_off	8.33333	0	No	No	No	Yes	0	0
108	3x27	3x31	chemokine_off	25	0	No	No	No	No	4	4
109	4x42	4x43	chemokine_off	8.33333	0	Yes	No	No	No	7	4
110	I2	I2x57	chemokine_off	25	0	No	No	Yes	Yes	0	7
111	4x40	4x44	chemokine_off	25	0	No	No	No	No	4	3
112	7x26	7x29	chemokine_off	25	0	No	No	No	No	1	3
113	2x37	I2x55	chemokine_off	25	0	No	No	No	No	7	4
114	5x59	5x60	chemokine_off	0	0	No	No	Yes	No	4	4
115	4x55	4x59	chemokine_off	0	0	No	No	No	No	3	5
116	3x23	3x26	chemokine_off	25	0	No	No	No	No	3	7
117	6x30	I3	chemokine_off	8.33333	0	No	Yes	No	No	5	0
118	4x47	4x51	chemokine_off	0	0	No	No	No	No	4	4
119	1x37	1x40	chemokine_off	0	0	No	No	No	No	5	3
120	6x65	E3	chemokine_off	0	0	No	No	Yes	Yes	0	0
121	5x51	5x55	chemokine_off	0	0	No	No	No	No	6	4
122	6x32	I2x50	chemokine_off	0	0	No	No	No	No	6	7
123	1x27	7x32	Shared	100	62.5	No	No	No	No	5	1
124	1x35	1x39	Shared	100	100	Yes	Yes	Yes	Yes	6	7
125	1x39	2x57	Shared	100	100	Yes	Yes	No	No	7	7
126	1x39	7x39	Shared	100	42.5	Yes	Yes	No	No	7	5
127	1x39	7x42	Shared	100	100	Yes	Yes	Yes	Yes	7	7
128	1x41	1x45	Shared	100	27.5	No	No	No	No	4	6
129	1x42	7x43	Shared	100	53.3333	No	No	No	Yes	7	5
130	1x43	1x47	Shared	100	100	No	No	No	No	7	6
131	1x43	2x58	Shared	100	100	No	No	No	No	7	9
132	1x49	7x50	Shared	100	12.5	No	No	No	No	7	9
133	1x50	2x50	Shared	100	100	No	Yes	No	No	9	9
134	1x50	7x50	Shared	100	100	No	Yes	No	No	9	9
135	1x53	2x47	Shared	100	50	No	No	No	No	9	9
136	1x57	2x40	Shared	100	37.0833	No	Yes	Yes	No	7	8
137	1x57	2x44	Shared	100	100	No	Yes	Yes	No	7	6
138	1x60	8x53	Shared	100	100	Yes	No	No	Yes	5	5
139	2x37	2x40	Shared	100	100	No	No	Yes	No	7	8
140	2x38	2x42	Shared	100	100	No	Yes	Yes	Yes	6	7
141	2x38	3x49	Shared	100	100	No	Yes	No	Yes	6	8
142	2x42	3x45	Shared	100	100	Yes	Yes	No	No	7	6
143	2x42	3x46	Shared	100	100	Yes	Yes	No	No	7	9
144	2x42	4x45	Shared	100	100	Yes	Yes	No	No	7	5
145	2x45	3x42	Shared	100	100	No	No	No	No	9	7
146	2x45	4x46	Shared	100	100	No	No	No	No	9	7
147	2x45	4x50	Shared	100	100	No	No	Yes	No	9	9
148	2x50	7x49	Shared	100	100	No	No	No	Yes	9	9
149	2x53	3x32	Shared	100	100	Yes	Yes	Yes	Yes	6	6
150	2x53	3x35	Shared	100	100	Yes	Yes	No	No	6	8
151	2x53	7x42	Shared	100	100	Yes	Yes	Yes	Yes	6	7
152	2x53	7x46	Shared	100	100	Yes	Yes	No	No	6	8
153	2x56	2x60	Shared	100	50	No	No	Yes	No	7	6
154	2x56	3x31	Shared	100	80	No	No	No	No	7	4
155	2x59	E1x52	Shared	100	100	No	No	Yes	Yes	6	7
156	2x59	3x28	Shared	100	100	No	No	No	No	6	6
157	2x60	3x32	Shared	100	100	Yes	No	Yes	Yes	6	6
158	2x60	Lig	Shared	100	100	Yes	No	Yes	Yes	6	0
159	2x62	E1x52	Shared	100	40	No	No	Yes	Yes	4	7
160	2x63	E1x50	Shared	100	100	No	No	Yes	Yes	4	8
161	E1x49	E2	Shared	100	100	No	No	Yes	Yes	4	3
162	E1x50	E1x52	Shared	100	100	Yes	Yes	Yes	Yes	8	7
163	3x25	E1x50	Shared	100	100	No	No	Yes	Yes	9	8
164	E1x50	E2	Shared	100	100	Yes	Yes	Yes	Yes	8	3
165	E1x50	E2x50	Shared	100	100	Yes	Yes	No	No	8	9
166	3x22	3x26	Shared	100	50	No	No	No	No	3	7
167	3x22	E2	Shared	100	100	No	No	Yes	Yes	3	3
168	3x25	E2x50	Shared	100	100	No	No	No	No	9	9
169	3x29	4x65	Shared	100	100	No	No	No	No	6	5
170	3x30	4x62	Shared	100	100	No	No	No	No	6	5
171	3x32	3x33	Shared	100	100	Yes	Yes	Yes	No	6	5
172	3x32	Lig	Shared	100	100	Yes	Yes	Yes	Yes	6	0
173	3x33	4x61	Shared	100	100	Yes	No	No	No	5	4
174	3x34	4x57	Shared	100	100	No	No	No	No	6	7
175	3x36	3x37	Shared	100	100	No	No	Yes	Yes	7	7
176	3x36	6x48	Shared	100	100	No	No	Yes	Yes	7	9
177	3x37	4x56	Shared	100	100	Yes	Yes	No	No	7	5
178	3x37	5x43	Shared	100	100	Yes	Yes	No	No	7	5
179	3x38	4x50	Shared	100	100	No	No	Yes	No	7	9
180	3x41	4x49	Shared	100	100	Yes	No	No	No	5	7
181	3x42	4x49	Shared	100	100	No	No	No	No	7	7
182	3x42	4x50	Shared	100	100	No	No	Yes	No	7	9
183	3x45	4x49	Shared	100	100	No	No	No	No	6	7
184	3x47	5x58	Shared	100	100	No	No	Yes	Yes	9	8
185	3x51	3x55	Shared	100	100	Yes	Yes	No	No	8	7
186	3x51	3x56	Shared	100	100	Yes	Yes	No	Yes	8	6
187	3x51	5x57	Shared	100	100	Yes	Yes	No	No	8	7
188	3x51	5x60	Shared	100	100	Yes	Yes	Yes	No	8	4
189	3x54	5x61	Shared	100	100	No	No	Yes	No	8	8
190	3x55	3x56	Shared	100	100	No	No	No	Yes	7	6
191	4x63	4x64	Shared	100	100	No	No	No	No	5	4
192	4x64	E2	Shared	100	100	No	No	Yes	Yes	4	3
193	4x64	5x35	Shared	100	100	No	No	Yes	No	4	3
194	4x65	E2x52	Shared	100	100	No	No	Yes	No	5	4
195	E2	E2	Shared	100	100	Yes	Yes	Yes	Yes	3	3
196	E2	E2x52	Shared	100	100	Yes	Yes	Yes	No	3	4
197	5x35	E2	Shared	100	100	Yes	No	Yes	Yes	3	3
198	5x40	6x59	Shared	100	100	No	No	No	No	5	5
199	5x47	6x52	Shared	100	100	No	Yes	No	No	8	8
200	6x39	7x52	Shared	100	3.33333	No	No	No	Yes	5	8
201	6x40	7x52	Shared	100	100	No	Yes	No	Yes	8	8
202	6x44	6x48	Shared	100	100	Yes	No	Yes	Yes	9	9
203	6x47	7x45	Shared	100	100	No	No	No	Yes	8	9
204	6x48	7x41	Shared	100	100	Yes	Yes	No	No	9	8
205	6x48	7x45	Shared	100	100	Yes	Yes	No	Yes	9	9
206	6x51	6x55	Shared	100	100	Yes	No	No	No	6	6
207	6x51	7x37	Shared	100	100	Yes	No	No	No	6	7
208	6x51	7x38	Shared	100	100	Yes	No	No	No	6	5
209	6x54	7x37	Shared	100	100	No	No	No	No	5	7
210	6x58	7x30	Shared	100	41.6667	No	No	No	No	4	4
211	7x35	Lig	Shared	100	100	No	No	Yes	Yes	4	0
212	7x38	Lig	Shared	100	100	No	No	Yes	Yes	5	0
213	Lig	Lig	Shared	100	100	Yes	Yes	Yes	Yes	0	0
214	E2	Lig	Shared	100	100	Yes	Yes	Yes	Yes	3	0
215	2x63	Lig	Shared	100	100	No	No	Yes	Yes	4	0
216	E2x51	Lig	Shared	100	100	No	No	Yes	Yes	4	0
217	7x31	Lig	Shared	100	100	No	No	Yes	Yes	4	0
218	7x34	Lig	Shared	100	100	No	No	Yes	Yes	4	0
219	Lig	NT	Shared	100	100	Yes	Yes	No	Yes	0	0
220	7x27	Lig	Shared	100	100	No	No	Yes	Yes	2	0
221	5x32	Lig	Shared	100	100	No	No	Yes	Yes	4	0
222	2x38	I2x57	Shared	100	100	No	Yes	Yes	Yes	6	7
223	2x50	7x46	Shared	100	100	No	No	No	No	9	8
224	2x63	E2	Shared	100	100	No	No	Yes	Yes	4	3
225	3x49	I2x57	Shared	100	100	No	Yes	Yes	Yes	8	7
226	3x53	I2x57	Shared	100	100	No	No	Yes	Yes	8	7
227	4x60	5x39	Shared	100	12.5	No	No	No	No	7	5
228	E2	E2x51	Shared	100	100	Yes	Yes	No	No	3	4
229	5x34	5x35	Shared	100	50	No	No	Yes	No	2	3
230	6x61	E3	Shared	100	100	No	No	Yes	Yes	4	0
231	7x26	E3	Shared	100	100	No	No	Yes	Yes	1	0
232	3x47	5x54	Shared	100	100	No	No	No	No	9	8
233	4x61	E2x52	Shared	100	100	No	No	Yes	No	4	4
234	6x60	E3	Shared	100	100	No	No	Yes	Yes	4	0
235	1x45	7x47	Shared	50	60	No	No	No	No	6	8
236	2x46	3x43	Shared	83.3333	100	No	No	Yes	No	9	8
237	2x62	2x66	Shared	50	50	No	No	No	No	4	4
238	2x41	4x42	Shared	50	100	No	No	Yes	No	7	7
239	3x44	5x50	Shared	50	100	No	No	Yes	Yes	8	8
240	1x50	2x51	Shared	50	27.5	No	Yes	No	No	9	7
241	1x47	1x51	Shared	50	23.3333	No	No	No	No	6	4
242	1x53	7x50	Shared	25	18.75	No	No	No	No	9	9
243	2x40	I1x51	Shared	50	22.5	Yes	No	No	No	8	6
244	6x50	7x37	Shared	25	100	No	No	No	No	9	7
245	1x36	2x65	Shared	50	13.3333	No	No	No	No	5	4
246	5x461	5x50	Shared	75	23.3333	No	No	Yes	Yes	6	8
247	7x24	NT	Shared	50	100	No	No	No	Yes	0	0
248	3x44	5x53	Shared	33.3333	100	No	No	No	No	8	6
249	5x56	5x60	Shared	50	100	No	No	Yes	No	4	4
250	1x36	1x37	Shared	50	50	No	No	No	No	5	5
251	5x58	5x61	Shared	33.3333	68.75	Yes	Yes	Yes	No	8	8
252	1x54	2x44	Shared	50	30	No	No	Yes	No	8	6
253	3x24	E1x52	Shared	25	100	No	No	Yes	Yes	5	7
254	6x49	6x50	Shared	33.3333	100	No	Yes	No	No	5	9
255	2x42	4x42	Shared	50	100	Yes	Yes	Yes	No	7	7
256	3x33	4x57	Shared	50	22.5	Yes	No	No	No	5	7
257	3x55	5x64	Shared	50	100	No	No	No	No	7	5
258	6x43	7x52	Shared	50	10	No	No	No	Yes	6	8
259	3x30	4x57	Shared	50	25	No	No	No	No	6	7
260	4x59	4x60	Shared	25	10	No	No	No	No	5	7
261	1x58	2x44	Shared	50	0	No	No	Yes	No	3	6
262	1x30	1x34	Shared	25	100	No	Yes	No	No	4	5
263	1x39	2x61	Shared	33.3333	100	Yes	Yes	No	No	7	7
264	8x54	8x55	Shared	50	12.5	Yes	No	No	No	7	5
265	4x41	4x45	Shared	50	50	No	Yes	No	No	4	5
266	6x54	7x33	Shared	25	22.5	No	No	No	No	5	5
267	1x46	2x54	Shared	16.6667	22.5	No	No	No	No	8	6
268	1x35	2x64	Shared	0	100	Yes	Yes	No	No	6	5
269	3x41	4x52	Shared	50	25.8333	Yes	No	No	No	5	4
270	7x23	7x26	Shared	50	14.5833	No	No	No	No	0	1
271	1x56	8x50	Shared	50	100	No	No	Yes	Yes	7	8
272	5x44	6x52	Shared	25	100	No	No	No	No	5	8
273	3x34	4x54	Shared	0	62.5	No	No	No	No	6	4
274	5x49	5x50	Shared	0	100	No	No	Yes	Yes	6	8
275	5x61	5x65	Shared	33.3333	10	Yes	No	No	No	8	8
276	7x56	8x47	Shared	25	0	No	No	No	No	6	8
277	5x52	5x56	Shared	25	22.5	No	No	No	No	4	4
278	1x47	2x55	Shared	0	12.5	No	No	No	No	6	4
279	5x41	5x45	Shared	0	10	No	No	No	No	4	4
280	3x52	I2x53	Shared	33.3333	15	Yes	No	No	No	5	5
281	1x48	1x49	Shared	0	17.5	No	No	No	No	4	7
282	I2x52	I2x55	Shared	50	42.5	No	Yes	No	No	4	4
283	8x48	8x51	Shared	25	56.25	Yes	No	No	No	5	8
284	4x51	4x55	Shared	0	10	No	No	No	No	4	3
285	4x48	4x52	Shared	25	12.5	No	No	No	No	4	4
286	7x54	8x50	Shared	25	100	No	No	Yes	Yes	7	8
287	6x49	6x53	Shared	0	35	No	Yes	No	No	5	6
288	1x55	1x59	Shared	0	45	No	No	No	Yes	3	4
289	5x60	5x63	Shared	0	10	Yes	No	No	No	4	4
290	7x51	7x55	Shared	0	50	No	No	No	No	7	7
291	8x54	8x58	Shared	0	10	Yes	No	No	No	7	6
292	1x26	7x28	Shared	25	22.5	No	No	No	No	0	3
293	1x30	7x36	Shared	25	12.5	No	Yes	No	No	4	5
294	1x29	1x33	Shared	8.33333	22.5	No	No	No	No	4	5
295	4x39	4x43	Shared	8.33333	10	No	No	No	No	3	4
296	1x52	8x54	Shared	0	75	No	No	Yes	No	6	7
297	6x42	6x46	Shared	0	13.3333	No	No	No	No	5	6
298	1x28	Lig	Shared	25	100	No	No	Yes	Yes	5	0
299	I2x52	I2x56	Shared	25	62.5	No	Yes	No	No	4	3
300	1x32	2x65	Shared	0	15.8333	No	No	No	No	7	4
301	7x55	8x50	Shared	8.33333	100	No	No	Yes	Yes	7	8
302	8x48	8x52	Shared	25	30.8333	Yes	No	No	No	5	4
303	1x44	1x45	Shared	0	10	No	No	No	No	6	6
304	I1x49	I1x50	Shared	8.33333	20	No	No	No	No	6	6
305	E3	Lig	chemokine_on	0	100	Yes	Yes	Yes	Yes	0	0
306	NT	NT	chemokine_on	0	100	No	Yes	No	Yes	0	0
307	1x35	7x35	chemokine_on	0	100	Yes	Yes	No	No	6	4
308	1x53	8x50	chemokine_on	0	100	No	No	Yes	Yes	9	8
309	1x57	8x50	chemokine_on	0	100	No	Yes	Yes	Yes	7	8
310	1x59	8x57	chemokine_on	0	100	No	Yes	No	No	4	5
311	2x39	3x49	chemokine_on	0	100	No	No	No	Yes	7	8
312	2x42	3x49	chemokine_on	0	100	Yes	Yes	No	Yes	7	8
313	2x52	3x35	chemokine_on	0	100	No	No	No	No	7	8
314	E1x51	E1x52	chemokine_on	0	100	No	No	Yes	Yes	3	7
315	3x40	6x48	chemokine_on	0	100	No	No	Yes	Yes	8	9
316	3x43	7x53	chemokine_on	0	100	Yes	No	Yes	Yes	8	9
317	3x46	7x53	chemokine_on	0	100	No	No	Yes	Yes	9	9
318	3x47	5x57	chemokine_on	0	100	No	No	No	No	9	7
319	3x50	5x58	chemokine_on	0	100	Yes	No	Yes	Yes	9	8
320	3x50	7x53	chemokine_on	0	100	Yes	No	Yes	Yes	9	9
321	5x39	E2	chemokine_on	0	100	No	No	Yes	Yes	5	3
322	5x32	E2	chemokine_on	0	100	No	No	Yes	Yes	4	3
323	5x40	6x55	chemokine_on	0	100	No	No	No	No	5	6
324	5x40	6x58	chemokine_on	0	100	No	No	No	No	5	4
325	5x47	6x49	chemokine_on	0	100	No	Yes	No	Yes	8	5
326	5x54	5x58	chemokine_on	0	100	No	No	Yes	Yes	8	8
327	5x54	6x44	chemokine_on	0	100	No	No	Yes	No	8	9
328	5x58	6x37	chemokine_on	0	100	Yes	Yes	No	No	8	7
329	5x58	6x41	chemokine_on	0	100	Yes	Yes	No	No	8	8
330	5x62	6x37	chemokine_on	0	100	No	No	No	No	4	7
331	6x36	7x56	chemokine_on	0	100	No	No	No	No	8	6
332	6x40	7x53	chemokine_on	0	100	No	Yes	Yes	Yes	8	9
333	6x45	6x49	chemokine_on	0	100	No	No	No	Yes	5	5
334	7x38	7x42	chemokine_on	0	100	No	No	Yes	Yes	5	7
335	7x45	7x49	chemokine_on	0	100	No	Yes	No	Yes	9	9
336	7x49	7x53	chemokine_on	0	100	No	Yes	Yes	Yes	9	9
337	7x52	7x53	chemokine_on	0	100	No	Yes	Yes	Yes	8	9
338	2x46	7x49	chemokine_on	0	100	No	No	No	Yes	9	9
339	2x49	3x38	chemokine_on	0	100	No	No	No	No	8	7
340	2x57	7x42	chemokine_on	0	100	No	No	Yes	Yes	7	7
341	3x37	5x42	chemokine_on	0	100	Yes	Yes	No	No	7	4
342	5x58	6x40	chemokine_on	0	100	Yes	Yes	No	Yes	8	8
343	5x62	6x34	chemokine_on	0	100	No	No	No	No	4	6
344	5x36	Lig	chemokine_on	0	100	No	No	Yes	Yes	3	0
345	6x62	Lig	chemokine_on	0	100	No	No	Yes	Yes	3	0
346	E3	E3	chemokine_on	0	100	Yes	Yes	Yes	Yes	0	0
347	5x36	E2x51	chemokine_on	0	100	No	No	No	No	3	4
348	3x56	I2x52	chemokine_on	0	65	No	Yes	No	Yes	6	4
349	7x28	NT	chemokine_on	0	53.3333	No	No	No	Yes	3	0
350	5x47	5x51	chemokine_on	0	62.5	No	Yes	No	No	8	6
351	1x52	7x55	chemokine_on	0	50	No	No	No	No	6	7
352	5x31	5x34	chemokine_on	0	70	No	No	No	No	0	2
353	1x38	7x39	chemokine_on	0	50	No	No	No	No	5	5
354	5x37	6x62	chemokine_on	0	53.3333	No	No	No	No	3	3
355	3x38	4x53	chemokine_on	0	60	No	No	No	No	7	8
356	1x31	7x32	chemokine_on	0	50	No	No	No	No	3	1
357	5x62	6x38	chemokine_on	0	30.8333	No	No	No	No	4	4
358	6x30	6x31	chemokine_on	0	35	No	Yes	No	No	5	4
359	1x31	1x35	chemokine_on	0	60	No	No	Yes	Yes	3	6
360	1x57	2x43	chemokine_on	0	75	No	Yes	No	No	7	8
361	1x46	1x50	chemokine_on	0	60	No	No	No	Yes	8	9
362	5x50	6x44	chemokine_on	0	50	Yes	Yes	Yes	No	8	9
363	6x56	6x60	chemokine_on	0	56.25	No	No	No	No	6	4
364	8x53	I1x48	chemokine_on	0	50	No	Yes	No	No	5	6
365	1x24	7x31	chemokine_on	0	60	No	No	No	No	0	4
366	6x64	E3	chemokine_on	0	32.5	No	No	Yes	Yes	1	0
367	2x48	2x52	chemokine_on	0	35	No	No	No	No	5	7
368	6x47	7x43	chemokine_on	0	50	No	No	No	Yes	8	5
369	1x43	2x57	chemokine_on	0	32.5	No	No	No	No	7	7
370	5x55	6x41	chemokine_on	0	35	No	No	No	No	4	8
371	4x56	5x46	chemokine_on	0	35	No	No	No	No	5	4
372	5x68	6x30	chemokine_on	0	58.3333	No	No	No	Yes	0	5
373	5x37	6x63	chemokine_on	0	53.3333	No	No	No	No	3	1
374	6x31	6x35	chemokine_on	0	60	No	No	No	No	4	5
375	1x46	7x47	chemokine_on	0	35.8333	No	No	No	No	8	8
376	I2x53	I2x57	chemokine_on	0	25	No	No	Yes	Yes	5	7
377	I2x51	I2x52	chemokine_on	0	50	No	No	No	Yes	5	4
378	5x41	6x59	chemokine_on	0	22.5	No	No	No	No	4	5
379	6x57	7x30	chemokine_on	0	50	No	No	No	No	4	4
380	1x30	7x32	chemokine_on	0	32.5	No	Yes	No	No	4	1
381	1x59	8x53	chemokine_on	0	50	No	Yes	No	Yes	4	5
382	1x30	1x33	chemokine_on	0	12.5	No	Yes	No	No	4	5
383	5x33	6x62	chemokine_on	0	22.5	No	No	No	No	3	3
384	5x66	6x34	chemokine_on	0	25	No	No	No	No	4	6
385	3x48	5x57	chemokine_on	0	10	No	No	No	No	6	7
386	6x29	I3	chemokine_on	0	50	No	No	No	No	4	0
387	3x39	7x45	chemokine_on	0	32.5	No	No	No	Yes	9	9
388	5x65	6x33	chemokine_on	0	0	No	No	No	No	8	7
389	7x25	7x29	chemokine_on	0	22.5	No	No	No	No	0	3
390	1x32	1x33	chemokine_on	0	25	No	No	No	No	7	5
391	5x47	5x48	chemokine_on	0	35	No	Yes	No	No	8	5
392	5x66	5x67	chemokine_on	0	12.5	No	No	No	No	4	5
393	8x60	8x61	chemokine_on	0	35	No	No	No	No	0	0
394	5x38	5x42	chemokine_on	0	50	No	No	No	No	4	4
395	7x43	7x48	chemokine_on	0	12.5	No	Yes	No	No	5	6
396	7x25	7x26	chemokine_on	0	10	No	No	No	No	0	1
397	4x38	4x41	chemokine_on	0	10	No	No	No	Yes	7	4
398	I1x48	I1x51	chemokine_on	0	30	No	No	No	No	6	6
399	5x65	6x30	chemokine_on	0	25.8333	No	No	No	Yes	8	5
400	7x40	7x43	chemokine_on	0	17.5	No	No	No	Yes	7	5
401	1x60	I1x49	chemokine_on	0	25	Yes	No	No	No	5	6
402	6x32	8x51	chemokine_on	0	22.5	No	No	No	No	6	8
403	6x31	I3	chemokine_on	0	10	No	No	No	No	4	0
404	4x38	4x40	chemokine_on	0	20	No	No	No	No	7	4
405	6x32	6x36	chemokine_on	0	3.33333	No	No	No	No	6	8
406	6x27	6x30	chemokine_on	0	20	No	No	No	Yes	1	5
407	4x41	4x44	chemokine_on	0	12.5	No	Yes	No	No	4	3
408	1x59	8x60	chemokine_on	0	10	No	Yes	No	No	4	0
409	8x49	8x53	chemokine_on	0	16.25	No	No	No	Yes	6	5
410	6x36	6x40	chemokine_on	0	15	No	No	No	Yes	8	8
411	3x56	I2x54	chemokine_on	0	12.5	No	Yes	No	No	6	5
412	5x55	5x59	chemokine_on	0	0	No	No	No	No	4	4
413	8x56	8x60	chemokine_on	0	10	No	No	No	No	4	0
414	6x26	6x29	chemokine_on	0	10	No	No	No	No	0	4
415	2x41	4x39	chemokine_on	0	0	No	No	No	No	7	3
416	3x24	3x27	chemokine_on	0	10	No	No	No	No	5	4
417	2x38	I2	chemokine_on	0	10	No	Yes	No	No	6	0
418	6x28	6x29	chemokine_on	0	15	No	No	No	No	3	4
419	3x21	E1x52	chemokine_on	0	0	No	No	Yes	Yes	7	7
420	1x25	1x28	chemokine_on	0	20	No	No	No	No	0	5
421	6x65	7x30	chemokine_on	0	10	No	No	No	No	0	4
422	2x67	Lig	chemokine_on	0	10	No	No	Yes	Yes	0	0
423	4x51	4x52	chemokine_on	0	12.5	No	No	No	No	4	4
424	6x46	6x47	chemokine_on	0	11.25	No	No	No	No	6	8
425	I2x52	I2x58	chemokine_on	0	12.5	No	Yes	No	No	4	0
426	3x23	3x27	chemokine_on	0	0	No	No	No	No	3	4
427	CT	I1x48	chemokine_on	0	0	No	No	No	No	4	6
428	1x40	2x61	chemokine_on	0	0	No	No	No	No	3	7
429	8x58	8x59	chemokine_on	0	6.25	No	No	No	No	6	0
430	4x47	4x48	chemokine_on	0	0	No	No	No	No	4	4
431	4x41	I2x59	chemokine_on	0	0	No	Yes	No	No	4	0

Orange: nodes, hubs and links specific of chemokine_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of chemokine_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	chemokine_off Avg Int. Strength	chemokine_on Avg Int. Strength	chemokine_off Num Of Links	chemokine_on Num Of Links	ConSurf
1	1x60	chemokine_off	0	0	4	2	5
2	2x40	chemokine_off	0	0	4	3	8
3	2x44	chemokine_off	0	0	4	3	6
4	2x60	chemokine_off	100	0	5	3	6
5	3x33	chemokine_off	0	0	4	3	5
6	3x41	chemokine_off	0	0	4	2	5
7	3x43	chemokine_off	0	0	4	2	8
8	3x50	chemokine_off	0	0	4	2	9
9	3x52	chemokine_off	0	0	4	1	5
10	4x42	chemokine_off	0	0	4	2	7
11	4x50	chemokine_off	25	25	5	3	9
12	E2x52	chemokine_off	50	12.5	4	3	4
13	5x35	chemokine_off	25	0	4	3	3
14	5x60	chemokine_off	0	0	4	3	4
15	5x61	chemokine_off	0	0	5	3	8
16	6x44	chemokine_off	100	25	6	3	9
17	6x51	chemokine_off	100	37.5	4	3	6
18	8x48	chemokine_off	0	0	4	2	5
19	8x54	chemokine_off	0	0	4	3	7
20	1x35	Shared	0	0	4	4	6
21	1x39	Shared	66.6667	25	7	5	7
22	2x42	Shared	0	87.5	5	6	7
23	2x53	Shared	25	31.6667	4	4	6
24	E1x50	Shared	100	87.5	7	5	8
25	E1x52	Shared	0	25	4	6	7
26	3x32	Shared	50	33.75	5	4	6
27	3x37	Shared	75	55	5	4	7
28	3x51	Shared	41.6667	43.75	6	4	8
29	I2x57	Shared	0	0	4	4	7
30	E2	Shared	100	100	14	13	3
31	5x50	Shared	0	0	5	4	8
32	5x58	Shared	0	100	4	7	8
33	6x48	Shared	100	87.5	5	5	9
34	7x42	Shared	75	82.5	5	4	7
35	7x53	Shared	0	95	5	6	9
36	8x50	Shared	0	64.1667	4	5	8
37	Lig	Shared	100	100	23	19	0
38	E3	Shared	25	25	5	7	0
39	NT	chemokine_on	0	83.75	3	5	0
40	1x30	chemokine_on	0	0	2	4	4
41	1x50	chemokine_on	0	0	3	4	9
42	1x57	chemokine_on	0	0	2	4	7
43	1x59	chemokine_on	0	0	2	4	4
44	2x38	chemokine_on	0	0	3	4	6
45	3x49	chemokine_on	8.33333	15	3	4	8
46	3x56	chemokine_on	0	0	2	4	6
47	I2x52	chemokine_on	0	0	2	5	4
48	4x41	chemokine_on	0	0	1	4	4
49	5x47	chemokine_on	0	0	1	4	8
50	6x30	chemokine_on	0	0	2	4	5
51	6x40	chemokine_on	25	0	2	4	8
52	6x49	chemokine_on	0	0	2	4	5
53	7x43	chemokine_on	0	0	1	4	5
54	7x45	chemokine_on	0	40	3	4	9
55	7x49	chemokine_on	0	25	1	4	9
56	7x52	chemokine_on	0	0	3	4	8
57	8x53	chemokine_on	0	0	2	4	5

Orange: nodes, hubs and links specific of chemokine_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of chemokine_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	chemokine_off Recurrence	chemokine_on Recurrence	chemokine_off Hub1?	chemokine_on Hub1?	chemokine_off Hub2?	chemokine_on Hub2?	ConSurf1	ConSurf2
1	1x50	2x51	chemokine_off	12.0959	1.17236	No	Yes	No	No	9	7
2	1x51	2x51	chemokine_off	10.0939	0	No	No	No	No	4	7
3	7x42	Lig	chemokine_off	23.0565	0	Yes	Yes	Yes	Yes	7	0
4	6x48	6x51	chemokine_off	78.674	0	Yes	Yes	Yes	No	9	6
5	6x44	6x48	chemokine_off	100	8.50134	Yes	No	Yes	Yes	9	9
6	3x40	6x44	chemokine_off	59.038	0	No	No	Yes	No	8	9
7	3x40	5x50	chemokine_off	58.2204	0	No	No	Yes	Yes	8	8
8	3x41	5x50	chemokine_off	54.0459	0	Yes	No	Yes	Yes	5	8
9	3x41	4x49	chemokine_off	50.6023	7.17311	Yes	No	No	No	5	7
10	2x38	2x42	chemokine_off	32.1277	6.58693	No	Yes	Yes	Yes	6	7
11	2x38	I2x57	chemokine_off	28.9672	4.41839	No	Yes	Yes	Yes	6	7
12	3x53	I2x57	chemokine_off	27.2743	2.22614	No	No	Yes	Yes	8	7
13	3x50	3x53	chemokine_off	26.477	0	Yes	No	No	No	9	8
14	2x39	3x50	chemokine_off	17.4057	0	No	No	Yes	No	7	9
15	2x37	2x39	chemokine_off	16.3426	0	No	No	No	No	7	7
16	2x37	2x40	chemokine_off	11.9457	1.17236	No	No	Yes	No	7	8
17	1x53	7x53	chemokine_off	33.1244	0	No	No	Yes	Yes	9	9
18	7x53	8x50	chemokine_off	26.2141	0	Yes	Yes	Yes	Yes	9	8
19	1x56	8x50	chemokine_off	18.7693	1.17236	No	No	Yes	Yes	7	8
20	2x60	Lig	chemokine_off	10.1488	1.18592	Yes	No	Yes	Yes	6	0
21	3x32	3x33	chemokine_off	23.8278	9.98882	Yes	Yes	Yes	No	6	5
22	3x33	3x37	chemokine_off	26.8843	0	Yes	No	Yes	Yes	5	7
23	3x36	3x37	chemokine_off	22.8138	6.27859	No	No	Yes	Yes	7	7
24	3x36	6x48	chemokine_off	26.3961	7.30187	No	No	Yes	Yes	7	9
25	3x43	6x44	chemokine_off	36.3686	0	Yes	No	Yes	No	8	9
26	6x44	6x45	chemokine_off	30.507	0	Yes	No	No	No	9	5
27	6x41	6x45	chemokine_off	27.855	0	No	No	No	No	8	5
28	3x43	6x41	chemokine_off	28.5454	0	Yes	No	No	No	8	8
29	5x54	6x41	chemokine_off	54.3348	0	No	No	No	No	8	8
30	3x47	5x54	chemokine_off	52.6246	1.49087	No	No	No	No	9	8
31	3x51	5x61	chemokine_off	28.3085	0	Yes	Yes	Yes	No	8	8
32	3x51	5x60	chemokine_off	10.2383	7.17989	Yes	Yes	Yes	No	8	4
33	5x40	Lig	chemokine_off	15.4124	0	No	No	Yes	Yes	5	0
34	5x40	6x59	chemokine_off	14.6815	3.62552	No	No	No	No	5	5
35	6x59	6x60	chemokine_off	13.6935	0	No	No	No	No	5	4
36	6x60	E3	chemokine_off	10.6746	2.36167	No	No	Yes	Yes	4	0
37	3x32	Lig	Shared	27.1414	52.0178	Yes	Yes	Yes	Yes	6	0
38	2x53	3x32	Shared	42.0425	59.9803	Yes	Yes	Yes	Yes	6	6
39	2x53	7x46	Shared	65.0123	95.9103	Yes	Yes	No	No	6	8
40	2x50	7x46	Shared	59.5089	96.1508	No	No	No	No	9	8
41	1x50	2x50	Shared	55.8111	44.6786	No	Yes	No	No	9	9
42	2x53	7x42	Shared	26.607	35.791	Yes	Yes	Yes	Yes	6	7
43	1x50	7x50	Shared	42.6867	37.414	No	Yes	No	No	9	9
44	1x53	7x50	Shared	36.9753	34.578	No	No	No	No	9	9
45	7x38	Lig	Shared	77.2497	10.392	No	No	Yes	Yes	5	0
46	6x51	7x38	Shared	77.2295	25.0398	Yes	No	No	No	6	5
47	3x45	4x49	Shared	43.3829	16.3623	No	No	No	No	6	7
48	2x42	3x45	Shared	40.7656	17.4804	Yes	Yes	No	No	7	6
49	E1x50	E1x52	Shared	11.3477	21.6481	Yes	Yes	Yes	Yes	8	7
50	E2	Lig	Shared	16.1144	28.3129	Yes	Yes	Yes	Yes	3	0
51	3x47	5x58	Shared	50.7208	28.0215	No	No	Yes	Yes	9	8
52	5x58	5x61	Shared	39.6331	22.9153	Yes	Yes	Yes	No	8	8
53	1x35	1x39	chemokine_on	1.41268	12.9909	Yes	Yes	Yes	Yes	6	7
54	1x39	7x42	chemokine_on	3.44648	16.6503	Yes	Yes	Yes	Yes	7	7
55	7x38	7x42	chemokine_on	0	21.5769	No	No	Yes	Yes	5	7
56	1x53	8x50	chemokine_on	0	32.6466	No	No	Yes	Yes	9	8
57	1x57	8x50	chemokine_on	0	22.7561	No	Yes	Yes	Yes	7	8
58	8x53	I1x48	chemokine_on	0	12.2116	No	Yes	No	No	5	6
59	I1x48	I1x51	chemokine_on	0	14.2581	No	No	No	No	6	6
60	2x40	I1x51	chemokine_on	1.1729	15.3458	Yes	No	No	No	8	6
61	1x57	2x40	chemokine_on	8.77943	17.5008	No	Yes	Yes	No	7	8
62	2x42	3x46	chemokine_on	2.07713	40.4263	Yes	Yes	No	No	7	9
63	3x46	7x53	chemokine_on	0	41.2496	No	No	Yes	Yes	9	9
64	7x49	7x53	chemokine_on	0	88.5711	No	Yes	Yes	Yes	9	9
65	2x50	7x49	chemokine_on	2.02802	100	No	No	No	Yes	9	9
66	2x63	E1x50	chemokine_on	5.6074	13.4754	No	No	Yes	Yes	4	8
67	2x63	Lig	chemokine_on	6.26896	14.3123	No	No	Yes	Yes	4	0
68	E1x50	E2	chemokine_on	6.26029	14.3632	Yes	Yes	Yes	Yes	8	3
69	6x48	7x45	chemokine_on	3.08248	15.0408	Yes	Yes	No	Yes	9	9
70	7x45	7x49	chemokine_on	0	22.0242	No	Yes	No	Yes	9	9
71	3x50	5x58	chemokine_on	0	32.6636	Yes	No	Yes	Yes	9	8
72	3x50	7x53	chemokine_on	0	33.2159	Yes	No	Yes	Yes	9	9
73	5x58	6x40	chemokine_on	0	34.5441	Yes	Yes	No	Yes	8	8
74	6x40	7x53	chemokine_on	0	39.0438	No	Yes	Yes	Yes	8	9
75	3x47	5x57	chemokine_on	0	27.8183	No	No	No	No	9	7
76	3x51	5x57	chemokine_on	2.05691	24.4028	Yes	Yes	No	No	8	7
77	3x51	3x56	chemokine_on	2.05113	12.1878	Yes	Yes	No	Yes	8	6
78	6x51	6x55	chemokine_on	1.07757	10.5479	Yes	No	No	No	6	6
79	6x50	7x37	chemokine_on	4.91983	10.7004	No	No	No	No	9	7
80	6x51	7x37	chemokine_on	6.37007	14.1463	Yes	No	No	No	6	7
81	5x58	6x37	chemokine_on	0	11.0968	Yes	Yes	No	No	8	7
82	E3	Lig	chemokine_on	0	10.2565	Yes	Yes	Yes	Yes	0	0
83	1x30	7x32	chemokine_on	0	10.9748	No	Yes	No	No	4	1
84	1x31	7x32	chemokine_on	0	13.184	No	No	No	No	3	1
85	1x31	1x35	chemokine_on	0	14.3564	No	No	Yes	Yes	3	6
86	5x65	6x30	chemokine_on	0	15.732	No	No	No	Yes	8	5
87	5x61	5x65	chemokine_on	1.56291	19.3372	Yes	No	No	No	8	8
88	6x30	6x31	chemokine_on	0	10.5411	No	Yes	No	No	5	4

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
1x27	7x32	Shared	4.5225	2.8235	0	0	2	2
1x35	1x39	Shared	10.4533	7.57717	1	0	1	1
1x35	Lig	chemokine_off	4.9475	0	1	0	1	0
1x39	2x57	Shared	3.7775	4.81087	1	1	1	2
1x39	7x39	Shared	5.48167	2.11033	1	1	1	2
1x39	7x42	Shared	8.04667	5.72792	1	1	1	1
1x39	Lig	chemokine_off	4.83	0	1	1	1	0
2x53	3x32	Shared	6.495	8.37767	1	0	2	1
2x53	7x42	Shared	7.49	5.82292	1	0	2	1
2x56	2x60	Shared	5.76167	3.32013	0	0	2	1
2x60	E1x50	chemokine_off	4.92	0	1	1	1	2
2x60	3x32	Shared	3.85833	6.43837	1	1	1	1
2x60	7x42	chemokine_off	4.95	0	1	1	1	1
2x60	Lig	Shared	19.5992	13.2288	1	1	1	0
2x63	E1x50	Shared	7.86583	7.07858	1	1	1	2
E1x49	E2	Shared	12.7367	4.30358	1	0	2	1
E1x50	E2	Shared	4.92083	4.71575	1	1	2	1
3x22	3x26	Shared	4.97417	3.00862	1	1	2	2
3x22	E2	Shared	10.655	6.00813	1	1	2	1
3x26	E2	chemokine_off	4.1025	0	1	0	2	1
3x29	4x65	Shared	8.53667	9.40683	1	0	1	2
3x29	Lig	chemokine_off	6.11417	0	1	0	1	0
3x32	3x33	Shared	4.5425	4.66946	1	1	1	2
3x32	7x42	chemokine_off	5.31917	0	1	1	1	1
3x32	Lig	Shared	8.17417	7.03704	1	1	1	0
3x33	4x61	Shared	16.2142	7.10508	0	0	2	2
4x61	5x39	chemokine_off	4.5425	0	0	0	2	2
4x64	E2	Shared	17.7042	10.4735	1	1	2	1
4x64	5x35	Shared	9.01917	3.74958	1	1	2	2
4x65	E2x52	Shared	4.9925	5.89521	0	0	2	1
E2	E2	Shared	52.6175	47.7058	1	1	1	1
E2	E2x52	Shared	8.125	4.88846	1	1	1	1
5x35	E2	Shared	10.0308	9.61037	1	1	2	1
5x36	E2	chemokine_off	6.21417	0	0	1	1	1
5x33	5x37	chemokine_off	5.435	0	0	0	2	2
5x37	6x60	chemokine_off	3.9275	0	0	0	2	2
5x40	6x59	Shared	9.3775	6.23112	1	0	1	2
6x51	6x55	Shared	8.93917	8.216	0	0	2	2
6x51	7x38	Shared	7.68917	7.31013	0	0	2	1
6x54	7x34	chemokine_off	3.8225	0	0	0	2	1
6x58	7x34	chemokine_off	3.66667	0	0	0	2	1
6x59	6x60	chemokine_off	4.9725	0	0	0	2	2
7x35	Lig	Shared	12.0367	3.66133	0	1	1	0
7x38	Lig	Shared	10.7117	7.10525	1	1	1	0
7x42	Lig	chemokine_off	9.175	0	1	1	1	0
E2x52	Lig	chemokine_off	6.985	0	1	1	1	0
E2	Lig	Shared	27.8592	42.0131	1	1	1	0
5x40	Lig	chemokine_off	3.845	0	1	0	1	0
2x63	Lig	Shared	4.87167	3.71908	1	1	1	0
E2x51	Lig	Shared	6.74333	8.90083	1	1	1	0
1x24	Lig	chemokine_off	3.68917	0	1	0	1	0
7x31	Lig	Shared	4.29167	3.77442	0	1	1	0
7x34	Lig	Shared	3.79583	4.93654	1	0	1	0
Lig	NT	Shared	16.7058	45.1584	1	1	0	1
7x27	Lig	Shared	3.60167	8.50812	0	0	1	0
5x32	Lig	Shared	5.9425	4.02	0	1	1	0
1x24	1x27	chemokine_off	5.13333	0	1	0	1	2
2x63	E2	Shared	4.07083	3.66242	1	1	1	1
E2	E2x51	Shared	7.9325	7.77508	1	1	1	1
6x61	E3	Shared	4.93917	4.77879	0	0	2	1
6x62	E3	chemokine_off	5.075	0	0	1	1	1
7x26	E3	Shared	5.24417	5.24829	0	1	2	1
4x61	E2x52	Shared	4.1175	5.031	0	0	2	1
6x60	E3	Shared	5.1925	4.59442	0	1	2	1
6x63	6x64	chemokine_off	3.375	0	0	0	2	2
6x62	6x63	chemokine_off	3.2075	0	0	1	1	2
7x24	NT	Shared	3.03333	5.77092	0	0	2	1
1x31	Lig	chemokine_off	2.73	0	0	0	1	0
1x39	2x61	Shared	2.66917	3.38458	1	1	1	2
1x35	2x64	Shared	2.49583	3.45617	1	0	1	2
1x24	7x28	chemokine_off	2.30667	0	1	0	1	2
5x31	E2	chemokine_off	2.235	0	0	0	2	1
1x38	1x39	chemokine_off	2.15333	0	0	0	2	1
1x34	1x35	chemokine_off	1.64667	0	0	0	2	1
1x25	NT	chemokine_off	1.12	0	0	0	2	1
1x28	Lig	Shared	1.0575	3.4085	0	1	1	0
6x65	E3	chemokine_off	0.425	0	0	0	2	1
E3	Lig	chemokine_on	0	3.46942	0	1	1	0
NT	NT	chemokine_on	0	17.9823	1	1	1	1
1x35	7x35	chemokine_on	0	3.69871	1	0	1	1
5x39	E2	chemokine_on	0	4.75838	0	1	2	1
5x32	E2	chemokine_on	0	3.79671	0	1	1	1
5x40	6x55	chemokine_on	0	5.2685	1	0	1	2
5x40	6x58	chemokine_on	0	3.7475	1	0	1	2
7x38	7x42	chemokine_on	0	6.37521	1	1	1	1
2x57	7x42	chemokine_on	0	5.53904	0	1	2	1
5x36	Lig	chemokine_on	0	4.34237	0	1	1	0
6x62	Lig	chemokine_on	0	3.48454	0	1	1	0
E3	E3	chemokine_on	0	3.44287	0	1	1	1
5x36	E2x51	chemokine_on	0	3.63183	0	1	1	1
7x28	NT	chemokine_on	0	3.33392	0	1	2	1
1x38	7x39	chemokine_on	0	3.04075	0	0	2	2
5x37	6x62	chemokine_on	0	3.03967	0	0	2	1
1x31	7x32	chemokine_on	0	3.0125	0	0	1	2
1x31	1x35	chemokine_on	0	2.81712	0	0	1	1
1x24	7x31	chemokine_on	0	2.5975	1	0	1	1
6x64	E3	chemokine_on	0	2.53046	0	0	2	1
5x37	6x63	chemokine_on	0	2.2515	0	0	2	2
5x33	6x62	chemokine_on	0	1.95275	0	0	2	1
1x25	1x28	chemokine_on	0	0.742	0	0	2	1
2x67	Lig	chemokine_on	0	0.717	0	0	1	0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	chemokine_off	ccr_off cxcr_off
	chemokine_on	ccr_on cxcr_on

Network Difference
Value	chemokine_off	chemokine_on
I_min	3.39917	3.36363
Number of Linked Nodes	278	285
Number of Specific Nodes	1 (0.36%)	8 (2.81%)
Number of Shared Nodes	277 (99.64%)	277 (97.19%)
Number of Links	304	309
Number of Specific Links	122 (40.13%)	127 (41.10%)
Number of Shared Links	182 (59.87%)	182 (58.90%)
Number of Hubs	38	38
Number of Specific Hubs	19 (50.00%)	19 (50.00%)
Number of Shared Hubs	19 (50.00%)	19 (50.00%)
Average % Shared Neighbours (Jaccard)	45.88
Average % Shared Neighbours (Otsuka)	55.20
Average % Shared Neighbours (Overlap Coefficient)	66.93
Average % Shared Cliques (k3-6)	59.00
Graphlets Similarity	0.581353

Paths Difference
Value	chemokine_off	chemokine_on
Number Of Nodes in MetaPath	51	50
Specific Nodes in MetaPath	24 (47.06%)	23 (46.00%)
Shared Nodes in MetaPath	277 (99.64%)	277 (99.64%)
Number Of Links MetaPath	52	52
Specific Links in MetaPath	36 (69.23%)	36 (69.23%)
Shared Links in MetaPath	182 (59.87%)	182 (59.87%)
Number of Shortest Paths	62688	55639
Length Of Smallest Path	3	3
Average Path Length	14.6356	12.4615
Length of Longest Path	36	26
Minimum Path Strength	0.949722	0.652729
Average Path Strength	5.94368	5.60428
Maximum Path Strength	22.7817	32.5483
Minimum Path Correlation	0.7	0.704708
Average Path Correlation	0.906068	0.931951
Maximum Path Correlation	0.983333	0.987458
Minimum % Of Corr. Nodes	3.22581	4.54545
Average % Of Corr. Nodes	41.0465	53.3907
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	45.7119	45.1662
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

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Download chemokine_off_on.zip<

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