Orange: nodes, hubs and links specific of class-a_on network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of class-b1_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.


Index Hub Owner class-a_on Avg Int. Strength class-b1_on Avg Int. Strength class-a_on Num Of Links class-b1_on Num Of Links ConSurf
11x59 class-a_on00515
22x41 class-a_on00525
32x42 class-a_on27.407810527
42x46 class-a_on15.469920429
5E1x50 class-a_on63.67750408
6E1x52 class-a_on8.928570407
73x30 class-a_on00416
83x51 class-a_on20.35750437
94x41 class-a_on00425
105x62 class-a_on00425
116x26 class-a_on00415
126x30 class-a_on00427
136x49 class-a_on00436
146x51 class-a_on30.814513436
156x59 class-a_on00404
167x49 class-a_on24.38160419
177x53 class-a_on66.62520539
188x50 class-a_on22.02380618
198x54 class-a_on00416
206x22 class-a_on00400
215x77 class-a_on00400
22NT Shared33.426563.51265
231x39 Shared17.261939.5833467
241x60 Shared00755
252x40 Shared00448
262x50 Shared57.722256.125569
27E2 Shared98.1664982084
285x58 Shared59.505340549
296x44 Shared2536449
306x48 Shared85.982668.3333558
31E3 Shared38.302340882
32Lig Shared99.79310017330
33E1 Shared073.33335100
341x36 class-b1_on020355
351x43 class-b1_on072.7917356
361x50 class-b1_on7.142860349
372x38 class-b1_on00346
382x57 class-b1_on020247
393x32 class-b1_on025245
403x33 class-b1_on014.1667244
413x34 class-b1_on010255
423x35 class-b1_on010248
433x42 class-b1_on14.285790348
443x44 class-b1_on010247
453x46 class-b1_on084.1667349
463x49 class-b1_on1.2896859.1667358
47I2 class-b1_on040180
484x60 class-b1_on043345
494x64 class-b1_on033.3333240
50E2x51 class-b1_on030255
515x40 class-b1_on4.166670244
525x41 class-b1_on044.375145
535x69 class-b1_on00345
546x29 class-b1_on00156
556x47 class-b1_on030148
567x45 class-b1_on00349
578x58 class-b1_on00246
   
Orange: nodes, hubs and links specific of class-a_on network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of class-b1_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Owner class-a_on Recurrence class-b1_on Recurrence class-a_on Hub1? class-b1_on Hub1? class-a_on Hub2? class-b1_on Hub2? ConSurf1 ConSurf2
11x39 7x42 class-a_on25.47292.52608YesYesNoNo77
27x42 Lig class-a_on31.22880NoNoYesYes70
3Lig NT class-a_on24.90763.2884YesYesYesYes05
41x38 7x39 class-a_on13.4071.25437NoNoNoNo45
51x39 7x39 class-a_on14.70740YesYesNoNo75
62x50 7x49 class-a_on22.28091.11577YesYesYesNo99
77x45 7x49 class-a_on60.42190NoYesYesNo99
86x48 7x45 class-a_on60.87265.84566YesYesNoYes89
93x36 6x48 class-a_on1000NoNoYesYes78
102x40 8x50 class-a_on37.19520YesYesYesNo88
112x37 2x40 class-a_on46.75261.25437NoNoYesYes78
122x37 2x38 class-a_on48.4410NoNoNoYes76
132x38 I2x57 class-a_on50.09240NoYesNoNo60
143x49 I2x57 class-a_on52.39030NoYesNoNo80
153x46 7x53 class-a_on47.36590NoYesYesNo99
163x43 7x53 class-a_on76.57010NoNoYesNo89
173x43 7x49 class-a_on53.89760NoNoYesNo89
188x50 I1x50 class-a_on17.37110YesNoNoNo87
192x46 3x42 class-a_on17.95850YesNoNoYes98
202x50 7x46 class-a_on10.79872.4637YesYesNoNo99
21E1x50 E1x52 class-a_on10.5660YesNoYesNo87
22E1x51 E1x52 class-a_on17.69620NoNoYesNo47
23E1x49 E1x51 class-a_on18.96340NoNoNoNo44
24E1x49 E2 class-a_on20.24530NoNoYesYes44
253x33 4x57 class-a_on12.77520NoYesNoNo47
266x44 6x48 class-a_on44.16280YesYesYesYes98
273x50 5x58 class-a_on31.37280NoNoYesYes99
283x47 5x58 class-a_on49.12440NoNoYesYes99
293x47 5x54 class-a_on46.56050NoNoNoNo98
303x51 5x57 class-a_on41.09286.28573YesNoNoNo78
313x47 5x57 class-a_on45.27120NoNoNoNo98
323x51 3x55 class-a_on26.95061.26824YesNoNoNo77
336x51 6x52 class-a_on16.00040YesNoNoNo67
346x51 Lig class-a_on25.64650YesNoYesYes60
355x47 6x52 class-a_on12.09920NoNoNoNo87
365x58 6x40 class-a_on14.92919.75779YesYesNoNo98
376x40 7x53 class-a_on14.92910NoNoYesNo89
386x30 6x31 class-a_on11.91070YesNoNoNo74
395x66 6x30 class-a_on35.6140NoNoYesNo57
405x62 5x66 class-a_on37.96730YesNoNoNo55
415x62 6x37 class-a_on44.69111.26824YesNoNoNo58
425x58 6x37 class-a_on45.55930YesYesNoNo98
43E3 NT class-a_on12.55730YesYesYesYes25
443x55 3x56 class-a_on16.35880NoNoNoNo76
45I2x52 I2x56 class-a_on12.27650NoNoNoNo47
463x56 I2x52 class-a_on14.81080NoNoNoNo64
473x50 7x53 class-a_on14.13480NoNoYesNo99
485x69 6x30 class-a_on22.60970NoYesYesNo57
495x69 6x26 class-a_on19.78350NoYesYesNo55
505x73 6x26 class-a_on11.30490NoNoYesNo05
515x73 5x77 class-a_on10.36280NoNoYesNo00
522x46 3x43 class-a_on22.71690YesNoNoNo98
533x46 3x50 class-a_on17.13830NoYesNoNo99
541x50 2x50 Shared18.82318.9577NoYesYesYes99
553x36 Lig Shared99.549374.0601NoNoYesYes70
562x42 3x49 Shared54.510921.4283YesNoNoYes78
572x42 3x46 Shared63.757922.5337YesNoNoYes79
581x60 I1x50 Shared16.632210.7142YesYesNoNo57
593x33 Lig Shared13.765312.3254NoYesYesYes40
605x54 6x44 Shared46.693514.7995NoNoYesYes89
61E2 Lig Shared36.105420.5066YesYesYesYes40
622x46 2x50 Shared12.3873100YesNoYesYes99
631x43 2x57 class-b1_on4.0970919.0894NoYesNoYes67
642x53 3x36 class-b1_on067.1264NoNoNoNo77
651x49 7x50 class-b1_on5.4122913.2229NoNoNoNo89
661x50 7x50 class-b1_on8.1092114.3837NoYesNoNo99
672x50 3x39 class-b1_on2.7079996.5626YesYesNoNo99
682x53 3x39 class-b1_on096.7012NoNoNoNo79
691x49 7x47 class-b1_on012.0552NoNoNoNo87
702x39 2x40 class-b1_on035.3962NoNoYesYes88
712x39 2x43 class-b1_on036.4323NoNoNoNo88
722x43 3x46 class-b1_on050.5735NoNoNoYes89
732x46 3x46 class-b1_on099.6847YesNoNoYes99
742x40 I1x50 class-b1_on027.9497YesYesNoNo87
758x49 I1x50 class-b1_on017.0761NoNoNoNo67
762x43 7x53 class-b1_on025.1672NoNoYesNo89
773x34 4x50 class-b1_on012.9977NoYesNoNo59
783x34 3x35 class-b1_on033.1786NoYesNoYes58
792x56 3x35 class-b1_on042.0978NoNoNoYes68
802x56 3x32 class-b1_on4.817543.5601NoNoNoYes65
813x32 Lig class-b1_on5.8593227.6066NoYesYesYes50
82E2 E2x51 class-b1_on0.066499210.9983YesYesNoYes45
833x34 4x53 class-b1_on012.9977NoYesNoNo58
843x44 5x54 class-b1_on013.6041NoYesNoNo78
856x43 6x44 class-b1_on033.8439NoNoYesYes79
863x46 6x43 class-b1_on047.9538NoYesNoNo97
875x58 6x44 class-b1_on018.1261YesYesYesYes99
883x49 I2 class-b1_on011.182NoYesNoYes80
897x52 7x53 class-b1_on6.9713341.4152NoNoYesNo89
906x43 7x53 class-b1_on024.9142NoNoYesNo79
918x47 8x49 class-b1_on1.4297315.9153NoNoNoNo86
924x64 5x40 class-b1_on017.589NoYesNoYes04
936x32 6x35 class-b1_on5.0982734.2216NoNoNoNo77
946x35 6x39 class-b1_on036.0962NoNoNoNo75
956x39 7x52 class-b1_on1.2117637.6694NoNoNoNo58
968x55 8x58 class-b1_on010.0073NoNoNoYes36
978x51 8x55 class-b1_on011.2027NoNoNoNo83
988x48 8x51 class-b1_on2.2203312.3913NoNoNoNo48
998x47 8x48 class-b1_on013.5729NoNoNoNo84
1005x69 6x29 class-b1_on021.4283NoYesNoYes56
1015x69 6x32 class-b1_on032.3331NoYesNoNo57
1026x29 I3 class-b1_on0.94576610.3261NoYesNoNo64
1031x43 2x53 class-b1_on030.6317NoYesNoNo67
1042x57 3x32 class-b1_on016.9618NoYesNoYes75

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Midway



Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Node1Node2OwnerNet1LinkStrengthNet2LinkStrengthComm1Comm2Node1ShellNode2Shell
NTNTShared21.7592427.2781111
E2NTclass-a_on14.235101111
1x351x39class-a_on4.1839200021
1x392x61Shared3.466174.153320112
1x397x42Shared3.640465.487470111
2x577x42class-a_on4.9770900111
3x32LigShared5.732587.903291110
3x334x57class-a_on3.7697201112
3x33LigShared6.120325.773051110
3x366x48class-a_on3.6939501112
3x36LigShared4.502528.734571110
3x406x48Shared8.3713210.65351022
4x60E2class-a_on4.3473201121
4x605x39class-a_on5.7072701122
5x39E2class-a_on6.8122401021
5x36E2class-a_on8.7136100021
E2E2Shared51.560212.38721111
E2E2x52class-a_on5.4550401111
E2E2x51Shared8.132194.962771111
E2x52LigShared6.3615510.4961110
E2LigShared9.5623116.73581110
5x395x43class-a_on4.8410101021
5x43Ligclass-a_on4.1455601110
5x446x52class-a_on4.8365700111
5x476x49class-a_on3.8424700022
5x476x52class-a_on11.979700021
6x517x37Shared3.32294.500751111
6x51Ligclass-a_on6.9279401110
6x547x34class-a_on3.4686500021
E3E3Shared4.497195.550991111
7x42Ligclass-a_on4.4959301110
1x397x39class-a_on4.5113600112
3x22E2class-a_on5.9149301021
3x375x43class-a_on3.6782900021
6x547x37class-a_on3.5302300021
6x61E3class-a_on4.3791201021
2x60LigShared4.152486.079061110
7x38LigShared6.796519.559910110
2x563x32Shared3.792843.596670021
3x294x65class-a_on3.9264801012
4x64E2class-a_on6.7845201021
6x516x52class-a_on3.5268401111
6x516x55class-a_on5.1891101112
7x34LigShared3.656087.044031010
E2x51Ligclass-a_on4.3973301110
LigNTShared4.1351477.52841101
6x587x34class-a_on3.1568300021
1x432x57Shared3.0262211.00370121
5x475x48class-a_on2.9892300022
3x29Ligclass-a_on2.9553401010
6x496x50class-a_on2.9096900022
3x223x26class-a_on2.8642201022
2x603x28Shared2.846933.136871112
2x622x66class-a_on2.8446900022
E1x49E2class-a_on2.820301021
2x64Ligclass-a_on2.7915600010
5x446x56class-a_on2.7717100111
E3NTclass-a_on2.5779701111
5x416x59class-a_on2.5450300112
5x35E2class-a_on2.5006601021
7x31NTclass-a_on2.2792200021
7x33E3class-a_on2.1486300121
1x32NTclass-a_on2.0374801011
1x281x30class-a_on1.9218200012
1x362x65class-a_on1.904300111
6x587x30class-a_on1.8232600021
1x291x33Shared1.769784.083890112
7x28NTclass-a_on1.7398601021
7x32NTclass-a_on1.6784201021
5x38E2class-a_on1.6491200021
2x63E1class-a_on1.6327600021
1x362x61Shared1.585274.65940112
6x60E3class-a_on1.5780101021
6x496x53class-a_on1.5690900021
1x322x67class-a_on1.4713601012
6x617x27class-a_on1.4392301022
1x321x33class-a_on1.4259901012
1x402x61class-a_on1.2310400022
6x62E2class-a_on1.2246401021
5x32E2class-a_on1.1955201021
3x213x24class-a_on1.1528900022
7x26E3class-a_on1.0114501021
1x361x37class-a_on0.97168400112
1x237x29class-a_on0.87535700012
7x24NTclass-a_on0.86740500021
7x267x29class-a_on0.72241801022
1x277x32class-a_on0.66382200022
1x221x23class-a_on0.44392900011
3x20E1class-a_on0.35427100021
4x68E2Shared0.3287811.06210121
E1x501NTclass-a_on0.29303200021
6x65E3class-a_on0.29069800021
1x247x28class-a_on0.21442900122
1x261x27class-a_on0.15451900012
2x672x68class-a_on0.15176600021
E1x48NTclass-a_on0.11578601021
3x19E1class-a_on0.096666700021
1x251x28class-a_on0.060241200011
5x27E2class-a_on0.05608701021
1x211x22class-a_on0.0500011
5x28E2class-a_on0.036821901021
3x29Ca5class-a_on0.03564601012
2x69E1Shared0.03201450.07481250021
4x69E2class-a_on0.021815500021
2x70E1class-a_on0.00080745300021
5x41Ligclass-b1_on05.98450110
7x37Ligclass-b1_on07.735240110
2x57Ligclass-b1_on04.356310110
E3Ligclass-b1_on04.30781110
7x30Ligclass-b1_on04.268790010
1x32Ligclass-b1_on014.98131010
1x36Ligclass-b1_on05.643850110
1x39Ligclass-b1_on04.580110
1x29Ligclass-b1_on07.646690110
E1Ligclass-b1_on019.76140110
E1NTclass-b1_on08.276250111
1x357x38class-b1_on05.118830021
1x361x39class-b1_on03.958040111
1x391x43class-b1_on04.271410112
1x397x38class-b1_on04.540950111
1x432x53class-b1_on04.555240122
1x437x42class-b1_on07.014410121
2x533x36class-b1_on07.21090021
2x572x61class-b1_on04.752630112
2x603x32class-b1_on08.723321111
E1E1class-b1_on019.27010111
3x26E2class-b1_on06.46670121
3x26E2x51class-b1_on023.75850121
3x334x60class-b1_on06.528581112
3x335x43class-b1_on07.533171111
3x363x40class-b1_on04.321131112
3x405x47class-b1_on011.47731022
4x604x64class-b1_on09.394271122
4x605x43class-b1_on09.944911121
4x644x68class-b1_on04.915161022
4x64E2x51class-b1_on017.80671021
5x41E2class-b1_on07.841910111
5x415x43class-b1_on04.104690111
5x415x44class-b1_on07.664040111
5x425x44class-b1_on06.75660021
6x517x33class-b1_on06.266251112
7x337x37class-b1_on07.985960121
7x397x43class-b1_on05.0610022
2x573x32class-b1_on04.98980111
E1E2class-b1_on06.523190111
5x44Ligclass-b1_on09.523630110
1x25Ligclass-b1_on04.405870010
1x361x40class-b1_on03.563080112
3x293x33class-b1_on03.316091011
6x506x51class-b1_on03.301770021
3x223x24class-b1_on03.24451022
2x64E2x52class-b1_on03.193950011
E2x50E2x52class-b1_on03.174973021
7x29E3class-b1_on03.120930021
7x427x43class-b1_on03.035711112
1x28Ligclass-b1_on02.912730010
2x65Ligclass-b1_on02.762990010
4x65E2x51class-b1_on02.71630021
6x54E3class-b1_on02.439910021
4x61E2x51class-b1_on02.383440021
1x24NTclass-b1_on02.34650121
6x53Ligclass-b1_on02.33950010
5x395x42class-b1_on02.332681022
5x486x52class-b1_on02.116580021
2x68Ligclass-b1_on02.11650010
1x21Ligclass-b1_on02.10580010
6x52Ligclass-b1_on02.0680110
3x24E1class-b1_on02.026980121
4x685x38class-b1_on01.9980122
1x26Ligclass-b1_on01.707830010
2x633x28class-b1_on01.666910022
2x67E1class-b1_on01.534420021
1x362x62class-b1_on01.3280112
1x241x27class-b1_on01.271850122
1x22Ligclass-b1_on01.094030010
7x27E3class-b1_on00.7683250021
1x23Ligclass-b1_on00.60640010
6x55E3class-b1_on00.5598540021
6x56Ligclass-b1_on00.4818330010
7x28E3class-b1_on00.4381021
1x19NTclass-b1_on00.4350021
1x371x40class-b1_on00.3872330022
2x66E1class-b1_on00.1688330021
3x21E1class-b1_on00.1643330021

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
Id Description
class-a_on sensory_on
alicarboxylic_on
amine_on
lipid_on
nucleotide_on
peptide_on
protein_on
class-b1_on glucagon_on
vip-pacap_on
pth_on
crf_on
calcitonin_on
Network Difference
Value class-a_on class-b1_on
Imin 3.32168 3.73973
Number of Linked Nodes 372 276
Number of Specific Nodes 103 (27.69%) 7  (2.54%)
Number of Shared Nodes 269 (72.31%) 269  (97.46%)
Number of Links 387 304
Number of Specific Links 295 (76.23%) 212  (69.74%)
Number of Shared Links 92 (23.77%) 92  (30.26%)
Number of Hubs 33 36
Number of Specific Hubs 21 (63.64%) 24  (66.67%)
Number of Shared Hubs 12 (36.36%) 12  (33.33%)
Average % Shared Neighbours (Jaccard) 13.94
Average % Shared Neighbours (Otsuka) 19.55
Average % Shared Neighbours (Overlap Coefficient) 25.54
Average % Shared Cliques (k3-6) 75.00
Graphlets Similarity 0.478214
Paths Difference
Value class-a_on class-b1_on
Number Of Nodes in MetaPath 59 51
Specific Nodes in MetaPath 41 (69.49%) 33  (64.71%)
Shared Nodes in MetaPath 269 (72.31%) 269  (72.31%)
Number Of Links MetaPath 62 51
Specific Links in MetaPath 53 (85.48%) 42  (82.35%)
Shared Links in MetaPath 92 (23.77%) 92  (23.77%)
Number of Shortest Paths 60057 52776
Length Of Smallest Path 3 3
Average Path Length 13.5836 13.3667
Length of Longest Path 29 30
Minimum Path Strength 0.326937 0.671667
Average Path Strength 4.12358 6.51131
Maximum Path Strength 11.4744 35.1088
Minimum Path Correlation 0.702059 0.701133
Average Path Correlation 0.899429 0.940253
Maximum Path Correlation 0.987148 0.991
Minimum % Of Corr. Nodes 3.7037 4.54545
Average % Of Corr. Nodes 37.1998 51.2194
Maximum % Of Corr. Nodes 100 100
Minimum Path Hubs % 0 0
Average Path Hubs % 37.0713 38.81
Maximum Path Hubs % 83.3333 100

Details about the values in these tables can be found in the corresponding documentation page .

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