psnGPCR

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Orange: nodes, hubs and links specific of class-a_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of class-a_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	class-a_off Int. Strength	class-a_on Int. Strength	class-a_off Hub1?	class-a_on Hub1?	class-a_off Hub2?	class-a_on Hub2?	ConSurf1	ConSurf2
1	1x39	2x57	class-a_off	100	0	Yes	Yes	Yes	No	7	7
2	1x53	7x53	class-a_off	100	0	No	No	Yes	Yes	9	9
3	2x40	I1x50	class-a_off	100	0	Yes	Yes	No	No	8	7
4	2x38	3x49	class-a_off	100	0	No	No	No	No	6	8
5	2x43	7x53	class-a_off	100	0	No	No	Yes	Yes	8	9
6	2x59	E1x52	class-a_off	100	0	No	No	Yes	Yes	5	7
7	3x25	E2	class-a_off	100	0	No	No	Yes	Yes	9	4
8	3x26	E2	class-a_off	100	0	No	No	Yes	Yes	7	4
9	3x41	5x50	class-a_off	100	0	No	No	No	No	5	9
10	3x43	6x44	class-a_off	100	0	No	No	Yes	Yes	8	9
11	3x44	5x54	class-a_off	100	0	No	No	No	No	7	8
12	3x49	3x50	class-a_off	100	0	No	No	Yes	No	8	9
13	3x50	6x33	class-a_off	100	0	Yes	No	No	No	9	8
14	3x50	6x34	class-a_off	100	0	Yes	No	No	No	9	6
15	7x34	E2	class-a_off	100	0	Yes	No	Yes	Yes	4	4
16	6x58	E2	class-a_off	100	0	No	No	Yes	Yes	4	4
17	5x47	5x51	class-a_off	100	0	Yes	No	No	No	8	7
18	5x51	6x45	class-a_off	100	0	No	No	No	No	7	6
19	5x58	6x38	class-a_off	100	0	Yes	Yes	No	No	9	5
20	5x65	6x31	class-a_off	100	0	No	No	Yes	No	8	4
21	6x40	7x49	class-a_off	100	0	No	No	Yes	Yes	8	9
22	6x40	7x52	class-a_off	100	0	No	No	No	No	8	8
23	6x48	Lig	class-a_off	100	0	Yes	Yes	Yes	Yes	8	0
24	6x58	E3	class-a_off	100	0	No	No	Yes	Yes	4	2
25	7x34	7x38	class-a_off	100	0	Yes	No	No	No	4	5
26	7x53	8x50	class-a_off	100	0	Yes	Yes	Yes	Yes	9	8
27	CT	CT	class-a_off	100	0	Yes	No	Yes	No	5	5
28	3x29	Lig	class-a_off	100	0	No	No	Yes	Yes	5	0
29	2x39	3x50	class-a_off	100	0	No	No	Yes	No	8	9
30	2x53	7x42	class-a_off	100	0	No	No	Yes	No	7	7
31	3x33	4x61	class-a_off	100	0	No	No	No	No	4	5
32	6x44	7x45	class-a_off	100	0	Yes	Yes	Yes	No	9	9
33	6x55	Lig	class-a_off	100	0	No	No	Yes	Yes	5	0
34	3x46	6x37	class-a_off	63.4422	0	No	No	No	No	9	8
35	3x50	3x53	class-a_off	69.9564	0	Yes	No	No	No	9	8
36	6x54	7x33	class-a_off	36.9454	0	No	No	No	No	5	4
37	1x50	2x47	class-a_off	75.068	0	Yes	No	No	No	9	9
38	3x30	3x34	class-a_off	53.3333	0	No	Yes	No	No	6	5
39	5x54	6x41	class-a_off	62.8571	0	No	No	No	No	8	8
40	3x50	6x37	class-a_off	55.881	0	Yes	No	No	No	9	8
41	3x50	6x30	class-a_off	57.8671	0	Yes	No	No	Yes	9	7
42	6x50	7x37	class-a_off	43.4524	0	No	No	No	No	9	6
43	3x54	5x65	class-a_off	52.1032	0	No	No	No	No	8	8
44	3x51	5x61	class-a_off	64.2143	0	Yes	Yes	No	No	7	8
45	5x34	5x35	class-a_off	32.1429	0	No	No	No	No	0	3
46	1x54	2x44	class-a_off	47.7549	0	No	No	Yes	No	7	5
47	3x56	I2x54	class-a_off	14.2857	0	Yes	No	No	No	6	5
48	2x42	4x46	class-a_off	47.619	0	Yes	Yes	No	No	7	7
49	8x50	8x54	class-a_off	53.2143	0	Yes	Yes	Yes	Yes	8	6
50	CT	I1x49	class-a_off	14.2857	0	Yes	No	No	No	5	5
51	7x54	8x54	class-a_off	43.5714	0	No	No	Yes	Yes	7	6
52	1x27	7x28	class-a_off	17.0635	0	No	No	No	No	0	0
53	5x46	5x461	class-a_off	25.3571	0	No	No	No	No	4	6
54	2x38	4x42	class-a_off	29.1446	0	No	No	No	No	6	7
55	1x31	7x35	class-a_off	19.4048	0	No	No	No	No	2	4
56	2x49	3x38	class-a_off	39.7375	0	No	No	No	No	8	7
57	8x49	8x52	class-a_off	33.0119	0	No	No	No	No	6	5
58	6x39	7x56	class-a_off	52.381	0	No	No	Yes	No	5	7
59	7x48	7x49	class-a_off	16.4652	0	No	No	Yes	Yes	5	9
60	5x41	6x56	class-a_off	31.5306	0	No	No	No	No	5	6
61	1x56	1x60	class-a_off	20.3571	0	No	No	Yes	Yes	7	5
62	2x54	2x57	class-a_off	43.6139	0	No	No	Yes	No	6	7
63	5x61	6x34	class-a_off	15.7727	0	No	No	No	No	8	6
64	8x56	CT	class-a_off	16.9167	0	No	No	Yes	No	4	5
65	8x49	I1x49	class-a_off	35.8095	0	No	No	No	No	6	5
66	1x47	2x55	class-a_off	23.4567	0	No	No	No	No	6	4
67	8x50	8x51	class-a_off	14.5238	0	Yes	Yes	No	No	8	8
68	1x60	CT	class-a_off	17.8333	0	Yes	Yes	Yes	No	5	5
69	5x58	5x62	class-a_off	32.9983	0	Yes	Yes	No	Yes	9	5
70	6x56	6x60	class-a_off	27.0595	0	No	No	No	No	6	5
71	1x57	1x61	class-a_off	14.2857	0	No	No	No	No	7	0
72	5x32	5x35	class-a_off	27.4206	0	No	No	No	No	0	3
73	1x60	8x57	class-a_off	32.818	0	Yes	Yes	No	No	5	5
74	6x35	7x56	class-a_off	25.3828	0	No	No	Yes	No	7	7
75	6x28	I3	class-a_off	14.6825	0	No	No	Yes	No	4	4
76	6x62	Lig	class-a_off	17.8571	0	No	No	Yes	Yes	0	0
77	5x45	5x49	class-a_off	18.9524	0	No	No	No	No	5	5
78	2x61	2x65	class-a_off	33.5714	0	No	No	No	No	6	4
79	1x58	2x44	class-a_off	22.4623	0	No	No	Yes	No	2	5
80	3x52	I2x56	class-a_off	22.3866	0	No	No	No	No	4	7
81	1x32	E1	class-a_off	20.4762	0	Yes	No	No	Yes	5	0
82	8x51	8x55	class-a_off	32.5139	0	No	No	No	No	8	3
83	4x63	E2	class-a_off	22.7778	0	No	No	Yes	Yes	5	4
84	7x55	7x56	class-a_off	25.8913	0	No	No	Yes	No	6	7
85	1x28	1x31	class-a_off	25.6905	0	No	No	No	No	3	2
86	1x27	7x31	class-a_off	31.5476	0	No	No	No	No	0	3
87	6x57	7x30	class-a_off	23.6111	0	No	No	No	No	4	4
88	6x27	6x31	class-a_off	20.7564	0	No	No	Yes	No	4	4
89	6x28	6x31	class-a_off	22.8095	0	No	No	Yes	No	4	4
90	3x21	E1x50	class-a_off	0	0	No	No	Yes	Yes	8	8
91	6x26	6x31	class-a_off	15.4762	0	No	Yes	Yes	No	5	4
92	7x26	7x30	class-a_off	14.4147	0	No	No	No	No	0	4
93	7x30	7x32	class-a_off	20	0	No	No	No	No	4	1
94	1x26	7x32	class-a_off	14.881	0	No	No	No	No	0	1
95	6x32	8x48	class-a_off	21.5238	0	No	No	No	No	7	4
96	1x29	NT	class-a_off	14.2857	0	No	No	Yes	Yes	3	5
97	5x52	5x56	class-a_off	16.9048	0	No	No	No	No	4	4
98	5x71	5x72	class-a_off	14.2857	0	No	No	No	No	2	5
99	7x23	E3	class-a_off	15.8333	0	No	No	Yes	Yes	0	2
100	I2x51	I2x53	class-a_off	17.2619	0	No	No	No	No	6	5
101	4x54	4x58	class-a_off	10.4075	0	No	No	No	No	3	3
102	5x64	5x67	class-a_off	20.0183	0	No	No	No	No	6	4
103	6x23	6x27	class-a_off	14.2857	0	No	No	No	No	4	4
104	5x33	6x63	class-a_off	0	0	No	No	No	No	0	0
105	6x25	I3	class-a_off	14.3353	0	No	No	Yes	No	4	4
106	6x29	6x33	class-a_off	10.9524	0	No	No	No	No	6	8
107	5x70	I3	class-a_off	15	0	No	No	Yes	No	4	4
108	4x41	4x44	class-a_off	4.2381	0	No	Yes	No	No	5	2
109	7x53	7x57	class-a_off	14.2857	0	Yes	Yes	No	No	9	0
110	1x23	7x25	class-a_off	14.2857	0	No	No	No	No	0	0
111	8x55	8x59	class-a_off	9.88095	0	No	No	No	No	3	4
112	5x69	6x27	class-a_off	10.5714	0	No	No	No	No	5	4
113	I2x55	I2x57	class-a_off	3.86905	0	No	No	No	No	4	0
114	4x55	4x59	class-a_off	0.42517	0	No	No	No	No	4	7
115	4x64	4x67	class-a_off	2.85714	0	No	No	No	No	0	0
116	2x50	Na1	class-a_off	7.05357	0	Yes	Yes	No	No	9	0
117	3x56	I2	class-a_off	3.57143	0	Yes	No	No	No	6	0
118	1x37	1x41	class-a_off	4.62585	0	No	No	No	No	5	5
119	8x58	8x63	class-a_off	7.14286	0	No	No	No	No	6	0
120	7x29	7x32	class-a_off	3.45238	0	No	No	No	No	0	1
121	6x461	6x47	class-a_off	0.238095	0	No	No	No	No	0	8
122	6x24	6x26	class-a_off	1.19048	0	No	No	No	Yes	3	5
123	1x55	8x61	class-a_off	8.57143	0	No	No	No	No	3	0
124	5x31	E2	class-a_off	6.4881	0	No	No	Yes	Yes	0	4
125	3x26	4x66	class-a_off	0.47619	0	No	No	No	No	7	0
126	2x36	7x55	class-a_off	2.85714	0	No	No	No	No	0	6
127	1x25	1x29	class-a_off	3.57143	0	No	No	No	No	0	3
128	5x29	E3	class-a_off	2.85714	0	No	No	Yes	Yes	0	2
129	5x70	5x71	class-a_off	0.248016	0	No	No	No	No	4	2
130	6x33	7x59	class-a_off	2.85714	0	No	No	No	No	8	0
131	5x76	I3	class-a_off	2.85714	0	No	No	Yes	No	0	4
132	8x58	8x62	class-a_off	0.423535	0	No	No	No	No	6	0
133	7x62	CT	class-a_off	1.42857	0	No	No	Yes	No	0	5
134	5x27	5x30	class-a_off	2.85714	0	No	No	No	No	0	0
135	4x36	4x40	class-a_off	1.42857	0	No	No	No	No	0	4
136	7x61	CT	class-a_off	1.42857	0	No	No	Yes	No	0	5
137	5x74	5x76	class-a_off	1.19048	0	No	No	No	No	0	0
138	6x21	6x24	class-a_off	0.686813	0	No	No	No	No	0	3
139	5x75	5x76	class-a_off	1.19048	0	No	No	No	No	0	0
140	5x28	NT	class-a_off	0	0	No	No	Yes	Yes	0	5
141	2x68	E2	class-a_off	0.297619	0	No	No	Yes	Yes	0	4
142	5x72	5x73	class-a_off	0.119048	0	No	No	No	No	5	0
143	4x34	4x38	class-a_off	0.47619	0	No	No	No	No	0	6
144	8x62	8x64	class-a_off	0	0	No	No	No	No	0	0
145	5x27	5x29	class-a_off	0	0	No	No	No	No	0	0
146	6x20	6x22	class-a_off	0.119048	0	No	No	No	Yes	0	0
147	4x35	4x39	class-a_off	0.47619	0	No	No	No	No	0	2
148	7x57	7x58	class-a_off	0	0	No	No	No	No	0	0
149	7x58	7x59	class-a_off	0	0	No	No	No	No	0	0
150	1x411	1x42	class-a_off	0	0	No	No	No	No	0	7
151	E3	NT	Shared	100	37.3602	Yes	Yes	Yes	Yes	2	5
152	NT	NT	Shared	100	100	Yes	Yes	Yes	Yes	5	5
153	E2	NT	Shared	100	100	Yes	Yes	Yes	Yes	4	5
154	7x31	NT	Shared	100	37.3913	No	No	Yes	Yes	3	5
155	1x35	2x64	Shared	100	43.3126	No	No	No	No	5	5
156	1x35	7x35	Shared	100	100	No	No	No	No	5	4
157	1x38	7x39	Shared	100	100	No	No	No	No	4	5
158	1x39	2x61	Shared	100	100	Yes	Yes	No	No	7	6
159	1x39	7x39	Shared	100	100	Yes	Yes	No	No	7	5
160	1x39	7x42	Shared	100	100	Yes	Yes	Yes	No	7	7
161	1x43	2x57	Shared	100	64.4643	No	No	Yes	No	6	7
162	1x50	2x50	Shared	100	100	Yes	No	Yes	Yes	9	9
163	1x50	7x50	Shared	100	100	Yes	No	No	No	9	9
164	1x55	1x59	Shared	100	100	No	No	No	Yes	3	5
165	1x57	2x44	Shared	100	100	No	No	Yes	No	7	5
166	2x37	2x40	Shared	100	100	No	No	Yes	Yes	7	8
167	2x42	3x45	Shared	100	100	Yes	Yes	No	No	7	7
168	2x42	3x46	Shared	100	100	Yes	Yes	No	No	7	9
169	2x45	3x42	Shared	100	100	No	No	No	No	9	8
170	2x45	4x46	Shared	100	100	No	No	No	No	9	7
171	2x45	4x50	Shared	100	100	No	No	No	No	9	9
172	2x46	7x49	Shared	100	100	No	Yes	Yes	Yes	9	9
173	2x50	7x46	Shared	100	100	Yes	Yes	No	No	9	9
174	2x50	7x49	Shared	100	100	Yes	Yes	Yes	Yes	9	9
175	2x53	3x35	Shared	100	100	No	No	No	No	7	8
176	2x53	7x46	Shared	100	100	No	No	No	No	7	9
177	2x57	7x42	Shared	100	100	Yes	No	Yes	No	7	7
178	2x59	3x28	Shared	100	100	No	No	No	No	5	5
179	2x60	3x28	Shared	100	53.2764	No	No	No	No	7	5
180	2x62	2x66	Shared	100	47.255	No	No	No	No	4	4
181	2x62	E1x52	Shared	100	27.0739	No	No	Yes	Yes	4	7
182	2x63	E1x50	Shared	100	100	No	No	Yes	Yes	5	8
183	E1x49	E1x51	Shared	100	45.6466	No	No	No	No	4	4
184	3x25	E1x50	Shared	100	100	No	No	Yes	Yes	9	8
185	E1x50	E2x50	Shared	100	100	Yes	Yes	No	No	8	9
186	3x25	E2x50	Shared	100	100	No	No	No	No	9	9
187	3x32	Lig	Shared	100	100	No	No	Yes	Yes	5	0
188	3x33	4x57	Shared	100	100	No	No	No	No	4	7
189	3x33	Lig	Shared	100	100	No	No	Yes	Yes	4	0
190	3x36	6x48	Shared	100	100	No	No	Yes	Yes	7	8
191	3x37	4x56	Shared	100	100	No	No	No	No	6	5
192	3x37	5x461	Shared	100	100	No	No	No	No	6	6
193	3x38	4x50	Shared	100	100	No	No	No	No	7	9
194	3x38	4x53	Shared	100	54.2952	No	No	No	No	7	8
195	3x40	5x50	Shared	100	47.1065	No	No	No	No	7	9
196	3x40	6x44	Shared	100	100	No	No	Yes	Yes	7	9
197	3x41	4x49	Shared	100	100	No	No	No	No	5	7
198	3x41	4x52	Shared	100	29.3923	No	No	No	No	5	4
199	3x42	4x49	Shared	100	100	No	No	No	No	8	7
200	3x47	5x54	Shared	100	100	No	No	No	No	9	8
201	3x51	3x55	Shared	100	100	Yes	Yes	No	No	7	7
202	3x51	5x57	Shared	100	100	Yes	Yes	No	No	7	8
203	3x51	5x60	Shared	100	100	Yes	Yes	No	No	7	4
204	3x54	5x61	Shared	100	100	No	No	No	No	8	8
205	4x60	5x39	Shared	100	100	No	No	No	No	5	6
206	5x39	E2	Shared	100	100	No	No	Yes	Yes	6	4
207	E2	E2x52	Shared	100	100	Yes	Yes	No	No	4	4
208	E2	E2	Shared	100	100	Yes	Yes	Yes	Yes	4	4
209	5x36	E2	Shared	100	100	No	No	Yes	Yes	4	4
210	E2	E2x51	Shared	100	100	Yes	Yes	No	No	4	5
211	E2	Lig	Shared	100	100	Yes	Yes	Yes	Yes	4	0
212	E2x52	Lig	Shared	100	100	No	No	Yes	Yes	4	0
213	5x40	6x59	Shared	100	54.7676	No	No	No	Yes	4	4
214	5x44	6x52	Shared	100	100	No	No	No	No	5	7
215	5x44	6x56	Shared	100	56.6359	No	No	No	No	5	6
216	5x47	6x52	Shared	100	100	Yes	No	No	No	8	7
217	5x56	5x60	Shared	100	62.8464	No	No	No	No	4	4
218	6x36	7x56	Shared	100	100	No	No	Yes	No	8	7
219	6x39	7x52	Shared	100	31.0227	No	No	No	No	5	8
220	6x44	6x48	Shared	100	100	Yes	Yes	Yes	Yes	9	8
221	6x47	7x45	Shared	100	100	No	No	Yes	No	8	9
222	6x48	7x41	Shared	100	100	Yes	Yes	No	No	8	8
223	6x48	7x45	Shared	100	100	Yes	Yes	Yes	No	8	9
224	6x51	6x55	Shared	100	100	No	Yes	No	No	6	5
225	6x51	Lig	Shared	100	100	No	Yes	Yes	Yes	6	0
226	6x54	7x34	Shared	100	100	No	No	Yes	No	5	4
227	6x54	7x37	Shared	100	100	No	No	No	No	5	6
228	6x57	6x61	Shared	100	100	No	No	No	No	4	3
229	6x58	7x34	Shared	100	43.2971	No	No	Yes	No	4	4
230	6x61	E3	Shared	100	100	No	No	Yes	Yes	3	2
231	E3	E3	Shared	100	100	Yes	Yes	Yes	Yes	2	2
232	7x42	Lig	Shared	100	100	Yes	No	Yes	Yes	7	0
233	1x43	2x58	Shared	100	100	No	No	No	No	6	8
234	7x38	Lig	Shared	100	100	No	No	Yes	Yes	5	0
235	1x57	2x40	Shared	100	32.4316	No	No	Yes	Yes	7	8
236	2x60	Lig	Shared	100	50.582	No	No	Yes	Yes	7	0
237	1x35	1x39	Shared	100	100	No	No	Yes	Yes	5	7
238	E1x50	E1x52	Shared	100	100	Yes	Yes	Yes	Yes	8	7
239	3x22	E2	Shared	100	100	No	No	Yes	Yes	3	4
240	3x29	4x65	Shared	100	100	No	No	No	No	5	0
241	3x55	3x56	Shared	100	100	No	No	Yes	No	7	6
242	4x64	E2	Shared	100	100	No	No	Yes	Yes	0	4
243	5x40	6x55	Shared	100	100	No	No	No	No	4	5
244	7x45	7x49	Shared	100	100	Yes	No	Yes	Yes	9	9
245	3x47	5x58	Shared	100	100	No	No	Yes	Yes	9	9
246	E1x49	E2	Shared	100	58.75	No	No	Yes	Yes	4	4
247	3x49	I2x57	Shared	100	100	No	No	No	No	8	0
248	Lig	NT	Shared	100	100	Yes	Yes	Yes	Yes	0	5
249	Lig	Lig	Shared	100	100	Yes	Yes	Yes	Yes	0	0
250	5x39	5x43	Shared	61.4286	100	No	No	No	No	6	5
251	1x49	7x50	Shared	78.5714	49.5323	No	No	No	No	8	9
252	2x42	4x45	Shared	62	52.4074	Yes	Yes	No	No	7	6
253	1x60	8x53	Shared	53.1349	100	Yes	Yes	No	No	5	5
254	8x47	8x50	Shared	50	56.8737	No	No	Yes	Yes	8	8
255	3x37	5x43	Shared	54.1667	100	No	No	No	No	6	5
256	3x54	5x64	Shared	54.3552	48.457	No	No	No	No	8	6
257	1x46	2x54	Shared	54.1071	53.0027	No	No	No	No	8	6
258	1x52	8x54	Shared	60.2381	62.0238	No	No	Yes	Yes	6	6
259	2x41	4x39	Shared	36.4171	47.5276	Yes	Yes	No	No	5	2
260	5x37	6x59	Shared	44.2857	55.268	No	No	No	Yes	3	4
261	3x30	4x62	Shared	64.2857	40.1819	No	Yes	No	No	6	4
262	5x49	5x50	Shared	47.877	66.7791	No	No	No	No	5	9
263	6x51	6x52	Shared	47.3214	100	No	Yes	No	No	6	7
264	1x51	2x51	Shared	53.191	16.7557	No	No	No	No	4	7
265	1x60	I1x50	Shared	71.4286	32.5479	Yes	Yes	No	No	5	7
266	5x47	5x48	Shared	27.9563	53.0666	Yes	No	No	No	8	4
267	2x41	4x42	Shared	44.3016	68.3531	Yes	Yes	No	No	5	7
268	1x32	NT	Shared	33.0357	24.2081	Yes	No	Yes	Yes	5	5
269	1x53	2x47	Shared	46.1905	36.7321	No	No	No	No	9	9
270	4x59	4x60	Shared	42.7608	60.4244	No	No	No	No	7	5
271	3x24	E1x52	Shared	52.0833	100	No	No	Yes	Yes	5	7
272	5x58	6x37	Shared	54.381	100	Yes	Yes	No	No	9	8
273	1x36	2x65	Shared	38.7996	30.2234	No	No	No	No	5	4
274	1x38	1x42	Shared	35.5937	31.5686	No	No	No	No	4	7
275	3x48	5x57	Shared	38.3433	30.2179	No	No	No	No	6	8
276	3x34	4x54	Shared	61.9048	100	No	No	No	No	5	3
277	5x47	6x49	Shared	34.0068	100	Yes	No	No	Yes	8	6
278	1x50	2x51	Shared	24.4116	100	Yes	No	No	No	9	7
279	2x551	3x31	Shared	51.6429	19.8499	No	No	No	No	4	4
280	5x64	5x68	Shared	20.754	32.8082	No	No	No	No	6	5
281	1x59	1x60	Shared	40.6548	31.5131	No	Yes	Yes	Yes	5	5
282	2x56	3x32	Shared	28.0159	100	No	No	No	No	6	5
283	2x41	4x43	Shared	36.1065	46.7064	Yes	Yes	No	No	5	3
284	5x33	6x62	Shared	31.4286	15.8929	No	No	No	No	0	0
285	1x46	7x47	Shared	22.2619	49.0243	No	No	No	No	8	7
286	8x50	I1x50	Shared	36.1905	100	Yes	Yes	No	No	8	7
287	5x42	5x46	Shared	60	35.6689	No	No	No	No	4	4
288	5x35	E2	Shared	34.2857	40	No	No	Yes	Yes	3	4
289	4x41	I2x56	Shared	42.1532	26.7966	No	Yes	No	No	5	7
290	3x44	5x53	Shared	24.3452	100	No	No	No	No	7	6
291	1x43	1x47	Shared	43.0476	48.0026	No	No	No	No	6	6
292	1x42	7x43	Shared	34.0295	47.8921	No	No	No	No	7	6
293	1x32	1x33	Shared	16.2063	18.235	Yes	No	No	No	5	2
294	6x50	7x40	Shared	36.4484	51.6435	No	No	No	No	9	7
295	1x45	7x47	Shared	30.5377	46.3008	No	No	No	No	5	7
296	2x50	3x39	Shared	57.6923	100	Yes	Yes	No	No	9	9
297	2x44	I1	Shared	28.9286	21.7391	Yes	No	No	No	5	0
298	I2x53	I2x57	Shared	35.873	37.4379	No	No	No	No	5	0
299	3x30	4x61	Shared	51.0714	100	No	Yes	No	No	6	5
300	4x38	4x41	Shared	33.6905	63.3954	No	No	No	Yes	6	5
301	2x56	3x31	Shared	30.3968	52.2673	No	No	No	No	6	4
302	1x30	1x31	Shared	20.6497	23.2336	No	No	No	No	3	2
303	3x48	3x52	Shared	37.5992	35.676	No	No	No	No	6	4
304	5x62	5x66	Shared	40.0549	33.3592	No	Yes	No	No	5	5
305	6x43	7x48	Shared	30.2665	56.2797	No	No	No	No	7	5
306	3x27	3x31	Shared	18.0456	28.3156	No	No	No	No	4	4
307	4x48	4x52	Shared	31.1667	18.4789	No	No	No	No	3	4
308	1x40	2x61	Shared	28.5714	17.9032	No	No	No	No	3	6
309	8x48	8x51	Shared	39.619	53.7268	No	No	No	No	4	8
310	3x56	I2x52	Shared	30.8433	72.619	Yes	No	No	No	6	4
311	5x51	5x55	Shared	25.4167	51.57	No	No	No	No	7	5
312	2x44	2x48	Shared	23.619	23.684	Yes	No	No	No	5	6
313	1x40	1x44	Shared	14.2857	15.8903	No	No	No	No	3	5
314	2x52	3x35	Shared	34.0278	100	No	No	No	No	6	8
315	6x49	6x53	Shared	18.8347	20.2845	No	Yes	No	No	6	5
316	1x34	7x36	Shared	16.0714	20.2847	No	No	No	No	4	5
317	4x38	4x40	Shared	17.7837	32.3544	No	No	No	No	6	4
318	1x22	1x23	Shared	14.6825	7.14286	No	No	No	No	0	0
319	1x34	1x38	Shared	22.1429	25.2854	No	No	No	No	4	4
320	5x38	E2	Shared	27.1429	38.3598	No	No	Yes	Yes	4	4
321	2x41	I1x51	Shared	32.7077	10.4027	Yes	Yes	No	No	5	6
322	I1x48	I1x51	Shared	31.6392	45.4037	No	No	No	No	6	6
323	6x61	7x27	Shared	17.0238	30.1902	No	No	No	No	3	0
324	1x48	1x49	Shared	12.4561	7.2389	No	No	No	No	4	8
325	6x42	6x46	Shared	9.33333	26.6429	No	No	No	No	5	5
326	6x38	6x42	Shared	8.59722	6.37681	No	No	No	No	5	5
327	5x59	5x63	Shared	23.4524	48.3747	No	No	No	No	3	3
328	7x51	7x55	Shared	5.73062	38.2597	No	No	No	No	7	6
329	3x51	I2x50	Shared	14.6825	14.2857	Yes	Yes	No	No	7	8
330	1x32	2x67	Shared	19.0476	18.8109	Yes	No	No	No	5	4
331	7x24	NT	Shared	20.8333	16.7702	No	No	Yes	Yes	0	5
332	1x23	7x29	Shared	14.2857	14.2857	No	No	No	No	0	0
333	4x68	E2	Shared	20	2.29167	No	No	Yes	Yes	0	4
334	5x60	5x63	Shared	15.7599	34.2245	No	No	No	No	4	3
335	1x20	7x25	Shared	14.2857	3.57143	No	No	No	No	0	0
336	1x41	1x45	Shared	10.0159	9.31562	No	No	No	No	5	5
337	3x23	3x24	Shared	11.131	10.3321	No	No	No	No	1	5
338	1x24	7x28	Shared	17.8571	1.42857	No	No	No	No	0	0
339	8x54	8x58	Shared	12.3929	6.79503	Yes	Yes	No	No	6	6
340	6x60	6x64	Shared	14.2857	15.6211	No	No	No	No	5	0
341	4x47	4x51	Shared	7.64172	2.43271	No	No	No	No	3	4
342	4x51	4x55	Shared	2.57143	1.27645	No	No	No	No	4	4
343	5x411	6x59	Shared	7.14286	7.14286	No	No	No	Yes	0	4
344	E1x501	NT	Shared	2.85714	2.85714	No	No	Yes	Yes	0	5
345	E1x48	NT	Shared	2.85714	2.85714	No	No	Yes	Yes	0	5
346	8x60	8x61	Shared	2.7091	11.5591	No	No	No	No	0	0
347	E1x47	E1x48	Shared	0.714286	1.90476	No	No	No	No	0	0
348	2x40	I1x52	Shared	1.19048	0.745342	Yes	Yes	No	No	8	0
349	4x34	4x37	Shared	1.42857	0.47619	No	No	No	No	0	0
350	4x69	E2	Shared	0.571429	0.595238	No	No	Yes	Yes	0	4
351	6x65	E3	Shared	0	7.3499	No	No	Yes	Yes	0	2
352	6x21	6x22	Shared	0.512821	0.621118	No	No	No	Yes	0	0
353	1x53	7x54	class-a_on	0	100	No	No	No	No	9	7
354	2x39	3x49	class-a_on	0	100	No	No	No	No	8	8
355	2x42	3x49	class-a_on	0	100	Yes	Yes	No	No	7	8
356	2x46	2x50	class-a_on	0	100	No	Yes	Yes	Yes	9	9
357	2x46	3x42	class-a_on	0	100	No	Yes	No	No	9	8
358	2x46	3x43	class-a_on	0	100	No	Yes	No	No	9	8
359	3x36	Lig	class-a_on	0	100	No	No	Yes	Yes	7	0
360	3x40	6x48	class-a_on	0	100	No	No	Yes	Yes	7	8
361	3x43	7x49	class-a_on	0	100	No	No	Yes	Yes	8	9
362	3x43	7x53	class-a_on	0	100	No	No	Yes	Yes	8	9
363	3x44	5x50	class-a_on	0	100	No	No	No	No	7	9
364	3x46	3x50	class-a_on	0	100	No	No	Yes	No	9	9
365	3x46	7x53	class-a_on	0	100	No	No	Yes	Yes	9	9
366	3x50	5x58	class-a_on	0	100	Yes	No	Yes	Yes	9	9
367	3x50	7x53	class-a_on	0	100	Yes	No	Yes	Yes	9	9
368	4x60	E2	class-a_on	0	100	No	No	Yes	Yes	5	4
369	5x43	Lig	class-a_on	0	100	No	No	Yes	Yes	5	0
370	5x51	6x44	class-a_on	0	100	No	No	Yes	Yes	7	9
371	5x54	6x44	class-a_on	0	100	No	No	Yes	Yes	8	9
372	5x58	6x40	class-a_on	0	100	Yes	Yes	No	No	9	8
373	5x58	6x41	class-a_on	0	100	Yes	Yes	No	No	9	8
374	6x40	7x53	class-a_on	0	100	No	No	Yes	Yes	8	9
375	6x51	7x37	class-a_on	0	100	No	Yes	No	No	6	6
376	7x52	7x53	class-a_on	0	100	No	No	Yes	Yes	8	9
377	7x54	8x50	class-a_on	0	100	No	No	Yes	Yes	7	8
378	3x34	4x57	class-a_on	0	100	No	No	No	No	5	7
379	5x62	6x34	class-a_on	0	100	No	Yes	No	No	5	6
380	2x38	I2x57	class-a_on	0	100	No	No	No	No	6	0
381	7x34	Lig	class-a_on	0	100	Yes	No	Yes	Yes	4	0
382	E2x51	Lig	class-a_on	0	100	No	No	Yes	Yes	5	0
383	4x56	5x46	class-a_on	0	33.4765	No	No	No	No	5	4
384	3x53	I2x53	class-a_on	0	51.5528	No	No	No	No	8	5
385	3x55	5x64	class-a_on	0	56.2169	No	No	No	No	7	6
386	I2x52	I2x56	class-a_on	0	44.0452	No	No	No	No	4	7
387	E1x51	E1x52	class-a_on	0	53.7398	No	No	Yes	Yes	4	7
388	6x49	6x50	class-a_on	0	58.4358	No	Yes	No	No	6	9
389	2x40	8x50	class-a_on	0	43.1056	Yes	Yes	Yes	Yes	8	8
390	3x22	3x26	class-a_on	0	61.5079	No	No	No	No	3	7
391	6x45	6x49	class-a_on	0	37.3559	No	No	No	Yes	6	6
392	2x42	4x42	class-a_on	0	54.4817	Yes	Yes	No	No	7	7
393	1x42	7x47	class-a_on	0	46.368	No	No	No	No	7	7
394	3x30	4x57	class-a_on	0	44.0726	No	Yes	No	No	6	7
395	3x47	5x57	class-a_on	0	55.2001	No	No	No	No	9	8
396	2x43	7x54	class-a_on	0	46.3716	No	No	No	No	8	7
397	5x41	6x59	class-a_on	0	55.6408	No	No	No	Yes	5	4
398	1x56	8x50	class-a_on	0	45.3869	No	No	Yes	Yes	7	8
399	2x49	4x50	class-a_on	0	43.6128	No	No	No	No	8	9
400	2x37	2x38	class-a_on	0	25.4818	No	No	No	No	7	6
401	3x29	E2	class-a_on	0	39.2128	No	No	Yes	Yes	5	4
402	4x63	4x64	class-a_on	0	33.3444	No	No	No	No	5	0
403	5x62	6x37	class-a_on	0	41.9968	No	Yes	No	No	5	8
404	8x47	8x49	class-a_on	0	40.0163	No	No	No	No	8	6
405	7x33	E3	class-a_on	0	36.0409	No	No	Yes	Yes	4	2
406	2x51	2x55	class-a_on	0	34.5554	No	No	No	No	7	4
407	I2x50	I2x51	class-a_on	0	29.7511	No	No	No	No	8	6
408	6x43	7x52	class-a_on	0	37.2124	No	No	No	No	7	8
409	5x65	6x33	class-a_on	0	29.555	No	No	No	No	8	8
410	1x56	8x54	class-a_on	0	27.8652	No	No	Yes	Yes	7	6
411	I2x51	I2x54	class-a_on	0	23.1574	No	No	No	No	6	5
412	1x54	2x47	class-a_on	0	30.4819	No	No	No	No	7	9
413	1x28	1x30	class-a_on	0	17.7847	No	No	No	No	3	3
414	1x60	I1x49	class-a_on	0	44.8706	Yes	Yes	No	No	5	5
415	6x58	7x30	class-a_on	0	33.3469	No	No	No	No	4	4
416	6x32	6x36	class-a_on	0	20.6552	No	No	No	No	7	8
417	1x29	1x33	class-a_on	0	18.0648	No	No	No	No	3	2
418	7x28	NT	class-a_on	0	38.3644	No	No	Yes	Yes	0	5
419	5x45	5x48	class-a_on	0	26.6071	No	No	No	No	5	4
420	1x58	1x59	class-a_on	0	25.9217	No	No	No	Yes	2	5
421	7x32	NT	class-a_on	0	32.9011	No	No	Yes	Yes	1	5
422	5x66	6x30	class-a_on	0	33.1717	No	No	No	Yes	5	7
423	2x63	E1	class-a_on	0	38.4144	No	No	No	Yes	5	0
424	6x31	6x35	class-a_on	0	25.8375	Yes	No	No	No	4	7
425	5x61	5x65	class-a_on	0	10.9337	No	No	No	No	8	8
426	1x36	2x61	class-a_on	0	24.8689	No	No	No	No	5	6
427	6x60	E3	class-a_on	0	18.1904	No	No	Yes	Yes	5	2
428	6x32	6x35	class-a_on	0	19.5997	No	No	No	No	7	7
429	5x69	6x30	class-a_on	0	12.1578	No	No	No	Yes	5	7
430	5x63	5x67	class-a_on	0	24.9802	No	No	No	No	3	4
431	5x66	5x70	class-a_on	0	30.421	No	No	No	No	5	4
432	1x31	7x32	class-a_on	0	24.8169	No	No	No	No	2	1
433	6x31	I3	class-a_on	0	20.2381	Yes	No	Yes	No	4	4
434	7x55	8x54	class-a_on	0	25.0908	No	No	Yes	Yes	6	6
435	6x30	6x31	class-a_on	0	23.9214	No	Yes	Yes	No	7	4
436	6x62	E2	class-a_on	0	22.8778	No	No	Yes	Yes	0	4
437	5x32	E2	class-a_on	0	13.1056	No	No	Yes	Yes	0	4
438	6x23	6x26	class-a_on	0	17.0807	No	No	No	Yes	4	5
439	8x48	I1	class-a_on	0	14.2857	No	No	No	No	4	0
440	1x59	8x57	class-a_on	0	20.8776	No	Yes	No	No	5	5
441	3x21	3x24	class-a_on	0	16.8445	No	No	No	No	8	5
442	I2x55	I2x56	class-a_on	0	9.68072	No	No	No	No	4	7
443	5x32	5x34	class-a_on	0	18.7888	No	No	No	No	0	0
444	4x40	4x44	class-a_on	0	9.53091	No	No	No	No	4	2
445	7x26	E3	class-a_on	0	14.9068	No	No	Yes	Yes	0	2
446	1x36	1x37	class-a_on	0	14.2857	No	No	No	No	5	5
447	3x30	4x58	class-a_on	0	18.4255	No	Yes	No	No	6	3
448	5x68	5x71	class-a_on	0	13.3783	No	No	No	No	5	2
449	1x60	8x56	class-a_on	0	15.9817	Yes	Yes	No	No	5	4
450	1x60	8x52	class-a_on	0	14.8896	Yes	Yes	No	No	5	5
451	5x62	6x38	class-a_on	0	12.3784	No	Yes	No	No	5	5
452	5x37	6x63	class-a_on	0	14.0166	No	No	No	No	3	0
453	7x26	7x29	class-a_on	0	9.70842	No	No	No	No	0	0
454	5x31	5x35	class-a_on	0	14.8997	No	No	No	No	0	3
455	1x27	7x32	class-a_on	0	11.6071	No	No	No	No	0	1
456	5x48	5x52	class-a_on	0	12.1417	No	No	No	No	4	4
457	6x29	I3	class-a_on	0	12.0859	No	No	Yes	No	6	4
458	8x52	8x55	class-a_on	0	8.80265	No	No	No	No	5	3
459	5x29	5x31	class-a_on	0	7.14286	No	No	No	No	0	0
460	6x25	6x26	class-a_on	0	8.71118	No	No	No	Yes	4	5
461	6x27	6x30	class-a_on	0	7.31419	No	No	No	Yes	4	7
462	3x22	4x67	class-a_on	0	7.14286	No	No	No	No	3	0
463	5x69	6x26	class-a_on	0	6.07727	No	No	No	Yes	5	5
464	6x24	6x28	class-a_on	0	8.82664	No	No	No	No	3	4
465	5x72	6x23	class-a_on	0	7.76397	No	No	No	No	5	4
466	7x23	7x25	class-a_on	0	7.06781	No	No	No	No	0	0
467	4x54	4x55	class-a_on	0	2.50518	No	No	No	No	3	4
468	7x23	7x26	class-a_on	0	4.78908	No	No	No	No	0	0
469	3x20	E1	class-a_on	0	7.76397	No	No	No	Yes	0	0
470	5x29	5x30	class-a_on	0	7.14286	No	No	No	No	0	0
471	5x69	6x28	class-a_on	0	4.06315	No	No	No	No	5	4
472	8x51	CT	class-a_on	0	0	No	No	Yes	No	8	5
473	5x73	6x26	class-a_on	0	3.0291	No	No	No	Yes	0	5
474	4x66	4x67	class-a_on	0	0.119048	No	No	No	No	0	0
475	8x58	8x59	class-a_on	0	1.65416	No	No	No	No	6	4
476	8x56	8x60	class-a_on	0	3.13492	No	No	No	No	4	0
477	1x57	7x62	class-a_on	0	2.85714	No	No	No	No	7	0
478	1x61	2x41	class-a_on	0	2.85714	No	No	Yes	Yes	0	5
479	7x61	7x62	class-a_on	0	2.85714	No	No	No	No	0	0
480	7x60	7x63	class-a_on	0	2.85714	No	No	No	No	0	0
481	2x38	I2	class-a_on	0	2.16356	No	No	No	No	6	0
482	1x26	1x27	class-a_on	0	0.714286	No	No	No	No	0	0
483	2x67	2x68	class-a_on	0	0.165631	No	No	No	No	4	0
484	1x63	1x64	class-a_on	0	4.28571	No	No	No	No	0	0
485	5x74	I3	class-a_on	0	2.51323	No	No	Yes	No	0	4
486	6x32	7x58	class-a_on	0	2.85714	No	No	No	No	7	0
487	1x60	1x63	class-a_on	0	2.85714	Yes	Yes	No	No	5	0
488	1x61	1x65	class-a_on	0	2.85714	No	No	No	No	0	0
489	3x19	E1	class-a_on	0	2.38095	No	No	No	Yes	0	0
490	3x18	3x19	class-a_on	0	2.38095	No	No	No	No	0	0
491	6x43	6x461	class-a_on	0	0	No	No	No	No	7	0
492	7x55	I4	class-a_on	0	2.85714	No	No	No	No	6	0
493	7x57	7x59	class-a_on	0	2.38095	No	No	No	No	0	0
494	7x57	8x50	class-a_on	0	2.38095	No	No	Yes	Yes	0	8
495	1x59	1x62	class-a_on	0	1.42857	No	Yes	No	No	5	0
496	1x25	1x28	class-a_on	0	1.53209	No	No	No	No	0	3
497	5x74	5x75	class-a_on	0	0.793651	No	No	No	No	0	0
498	5x27	E2	class-a_on	0	0.621118	No	No	Yes	Yes	0	4
499	7x64	I4	class-a_on	0	0	No	No	No	No	0	0
500	7x57	7x63	class-a_on	0	0	No	No	No	No	0	0
501	5x72	5x76	class-a_on	0	0.200138	No	No	No	No	5	0
502	1x21	1x22	class-a_on	0	0	No	No	No	No	0	0
503	I2x52	I2x58	class-a_on	0	0.892857	No	No	No	No	4	0
504	8x61	8x62	class-a_on	0	0.396825	No	No	No	No	0	0
505	6x22	6x23	class-a_on	0	0.595238	No	Yes	No	No	0	4
506	5x79	6x20	class-a_on	0	0.621118	No	No	No	No	0	0
507	5x28	E2	class-a_on	0	0.621118	No	No	Yes	Yes	0	4
508	3x29	Ca5	class-a_on	0	0.621118	No	No	No	No	5	0
509	5x24	5x27	class-a_on	0	0.621118	No	No	No	No	0	0
510	2x69	E1	class-a_on	0	0.621118	No	No	No	Yes	0	0
511	3x17	3x18	class-a_on	0	0.662526	No	No	No	No	0	0
512	8x60	8x63	class-a_on	0	0.238095	No	No	No	No	0	0
513	1x65	1x66	class-a_on	0	0	No	No	No	No	0	0
514	5x77	5x80	class-a_on	0	0.621118	No	Yes	No	No	0	0
515	3x16	E1x49	class-a_on	0	0.621118	No	No	No	No	0	4
516	2x36	2x37	class-a_on	0	0.621118	No	No	No	No	0	7
517	5x77	5x78	class-a_on	0	0.26455	No	Yes	No	No	0	0
518	5x25	5x28	class-a_on	0	0.621118	No	No	No	No	0	0
519	5x73	5x77	class-a_on	0	0.26455	No	No	No	Yes	0	0
520	2x35	I2x54	class-a_on	0	0.621118	No	No	No	No	0	5
521	4x35	I2x54	class-a_on	0	0.396825	No	No	No	No	0	5
522	5x78	5x79	class-a_on	0	0	No	No	No	No	0	0
523	5x24	5x26	class-a_on	0	0	No	No	No	No	0	0
524	6x19	6x22	class-a_on	0	0	No	No	No	Yes	0	0
525	4x41	I2x59	class-a_on	0	0	No	Yes	No	No	5	0
526	2x34	I1	class-a_on	0	0	No	No	No	No	0	0
527	5x77	5x81	class-a_on	0	0.0529101	No	Yes	No	No	0	0
528	6x14	6x16	class-a_on	0	0.0992063	No	No	No	No	0	0
529	4x36	4x37	class-a_on	0	0.132275	No	No	No	No	0	0
530	4x37	4x41	class-a_on	0	0	No	No	No	Yes	0	5
531	5x80	5x84	class-a_on	0	0	No	No	No	No	0	0
532	6x14	6x17	class-a_on	0	0.0440917	No	No	No	No	0	0
533	5x83	5x86	class-a_on	0	0	No	No	No	No	0	0
534	2x70	E1	class-a_on	0	0	No	No	No	Yes	0	0
535	6x18	6x22	class-a_on	0	0.0110229	No	No	No	Yes	0	0
536	6x14	6x15	class-a_on	0	0.0110229	No	No	No	No	0	0
537	6x16	6x20	class-a_on	0	0.0110229	No	No	No	No	0	0

Orange: nodes, hubs and links specific of class-a_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of class-a_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	class-a_off Avg Int. Strength	class-a_on Avg Int. Strength	class-a_off Num Of Links	class-a_on Num Of Links	ConSurf
1	1x32	class-a_off	0	0	4	3	5
2	1x50	class-a_off	0	7.14286	4	3	9
3	2x44	class-a_off	14.2857	0	5	3	5
4	2x57	class-a_off	6.47619	0	4	2	7
5	3x50	class-a_off	43.5684	0	7	3	9
6	3x56	class-a_off	0	0	4	2	6
7	5x47	class-a_off	0	21.4749	4	3	8
8	I3	class-a_off	9.52381	0	4	3	4
9	6x31	class-a_off	4.7619	0	4	3	4
10	7x34	class-a_off	14.2857	10.7143	4	3	4
11	7x42	class-a_off	41.0714	26.627	4	3	7
12	7x45	class-a_off	27.4048	0	4	3	9
13	7x56	class-a_off	0	0	4	1	7
14	CT	class-a_off	14.2857	0	7	1	5
15	NT	Shared	38.5714	33.4265	12	12	5
16	1x39	Shared	34.3864	17.2619	5	4	7
17	1x60	Shared	9.52381	0	6	7	5
18	2x40	Shared	0	0	4	4	8
19	2x41	Shared	4.7619	0	4	5	5
20	2x42	Shared	26.8844	27.4078	4	5	7
21	2x50	Shared	19.1429	57.7222	5	5	9
22	E1x50	Shared	63.4722	63.6775	5	4	8
23	E1x52	Shared	14.2857	8.92857	4	4	7
24	3x51	Shared	14.2857	20.3575	5	4	7
25	E2	Shared	100	98.1664	22	21	4
26	5x58	Shared	17.8571	59.5053	4	5	9
27	6x44	Shared	34.381	26.1905	4	4	9
28	6x48	Shared	86.4845	85.9826	5	5	8
29	E3	Shared	23.2143	38.3023	8	8	2
30	7x49	Shared	1.78571	24.3816	5	4	9
31	7x53	Shared	44.9901	66.6252	4	5	9
32	8x50	Shared	24.0952	22.0238	5	6	8
33	8x54	Shared	0	0	4	4	6
34	Lig	Shared	100	85.5072	15	15	0
35	1x59	class-a_on	4.7619	0	2	5	5
36	2x46	class-a_on	0	15.4699	1	4	9
37	3x30	class-a_on	0	0	3	4	6
38	4x41	class-a_on	0	0	3	4	5
39	5x62	class-a_on	0	0	2	4	5
40	6x26	class-a_on	0	0	2	4	5
41	6x30	class-a_on	0	0	1	4	7
42	6x49	class-a_on	0	0	2	4	6
43	6x51	class-a_on	32.7551	30.8145	3	4	6
44	6x59	class-a_on	0	0	3	4	4
45	E1	class-a_on	0	0	1	5	0
46	6x22	class-a_on	0	0	2	4	0
47	5x77	class-a_on	0	0	0	4	0

Orange: nodes, hubs and links specific of class-a_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of class-a_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	class-a_off Recurrence	class-a_on Recurrence	class-a_off Hub1?	class-a_on Hub1?	class-a_off Hub2?	class-a_on Hub2?	ConSurf1	ConSurf2
1	2x57	7x42	class-a_off	12.0298	5.44924	Yes	No	Yes	No	7	7
2	2x53	7x46	class-a_off	54.8042	8.10921	No	No	No	No	7	9
3	2x53	7x42	class-a_off	55.1881	0	No	No	Yes	No	7	7
4	6x48	Lig	class-a_off	86.9307	0	Yes	Yes	Yes	Yes	8	0
5	1x53	2x47	class-a_off	95.1702	2.85577	No	No	No	No	9	9
6	1x50	2x47	class-a_off	95.8738	0	Yes	No	No	No	9	9
7	7x53	8x50	class-a_off	41.2199	0	Yes	Yes	Yes	Yes	9	8
8	1x53	7x53	class-a_off	94.2682	0	No	No	Yes	Yes	9	9
9	2x40	I1x50	class-a_off	12.2409	0	Yes	Yes	No	No	8	7
10	2x38	3x49	class-a_off	12.3912	0	No	No	No	No	6	8
11	3x49	3x50	class-a_off	19.3961	0	No	No	Yes	No	8	9
12	3x50	6x37	class-a_off	33.94	0	Yes	No	No	No	9	8
13	3x46	6x37	class-a_off	34.6245	0	No	No	No	No	9	8
14	2x42	4x46	class-a_off	35.9807	0	Yes	Yes	No	No	7	7
15	2x45	4x46	class-a_off	36.2494	1.66617	No	No	No	No	9	7
16	2x45	3x42	class-a_off	37.5288	9.90468	No	No	No	No	9	8
17	3x42	4x49	class-a_off	37.7719	6.63145	No	No	No	No	8	7
18	3x41	4x49	class-a_off	38.2773	4.98374	No	No	No	No	5	7
19	3x41	5x50	class-a_off	39.7742	0	No	No	No	No	5	9
20	3x40	5x50	class-a_off	41.2327	6.49845	No	No	No	No	7	9
21	3x40	6x44	class-a_off	41.7125	2.9703	No	No	Yes	Yes	7	9
22	3x50	6x33	class-a_off	65.7433	0	Yes	No	No	No	9	8
23	6x33	7x59	class-a_off	66.6357	0	No	No	No	No	8	0
24	7x58	7x59	class-a_off	67.1283	0	No	No	No	No	0	0
25	7x57	7x58	class-a_off	67.6401	0	No	No	No	No	0	0
26	7x53	7x57	class-a_off	68.1711	0	Yes	Yes	No	No	9	0
27	3x25	E1x50	class-a_off	12.8774	1.3854	No	No	Yes	Yes	9	8
28	3x25	E2	class-a_off	15.4107	0	No	No	Yes	Yes	9	4
29	5x39	5x43	class-a_off	10.0947	2.00236	No	No	No	No	6	5
30	5x39	E2	class-a_off	18.5357	1.61445	No	No	Yes	Yes	6	4
31	3x50	6x34	class-a_off	67.848	0	Yes	No	No	No	9	6
32	3x51	5x61	class-a_off	37.113	0	Yes	Yes	No	No	7	8
33	5x61	6x34	class-a_off	66.1688	0	No	No	No	No	8	6
34	3x54	5x61	class-a_off	29.9994	4.34831	No	No	No	No	8	8
35	3x54	5x65	class-a_off	23.3879	0	No	No	No	No	8	8
36	5x65	6x31	class-a_off	21.472	0	No	No	Yes	No	8	4
37	6x40	7x49	class-a_off	10.1555	0	No	No	Yes	Yes	8	9
38	6x54	7x34	class-a_off	15.4139	1.30412	No	No	Yes	No	5	4
39	6x57	6x61	class-a_off	11.9882	1.37432	No	No	No	No	4	3
40	6x61	E3	class-a_off	13.8946	3.45426	No	No	Yes	Yes	3	2
41	2x38	4x42	class-a_off	11.1086	0	No	No	No	No	6	7
42	3x48	5x57	class-a_off	15.174	3.26215	No	No	No	No	6	8
43	4x41	I2x56	class-a_off	10.2322	9.74213	No	Yes	No	No	5	7
44	3x52	I2x56	class-a_off	11.2973	0	No	No	No	No	4	7
45	3x48	3x52	class-a_off	13.2453	1.63292	No	No	No	No	6	4
46	6x57	7x30	class-a_off	10.2034	0	No	No	No	No	4	4
47	6x28	6x31	class-a_off	10.8751	0	No	No	Yes	No	4	4
48	1x39	7x42	Shared	19.0027	26.112	Yes	Yes	Yes	No	7	7
49	7x42	Lig	Shared	58.5018	31.8346	Yes	No	Yes	Yes	7	0
50	Lig	NT	Shared	28.9758	24.8707	Yes	Yes	Yes	Yes	0	5
51	E3	NT	Shared	17.5473	12.5573	Yes	Yes	Yes	Yes	2	5
52	1x50	2x50	Shared	100	18.823	Yes	No	Yes	Yes	9	9
53	2x50	7x46	Shared	54.8138	10.7987	Yes	Yes	No	No	9	9
54	2x50	7x49	Shared	50.0992	22.2809	Yes	Yes	Yes	Yes	9	9
55	7x45	7x49	Shared	51.0523	60.4219	Yes	No	Yes	Yes	9	9
56	6x48	7x45	Shared	48.3975	60.8726	Yes	Yes	Yes	No	8	9
57	1x60	I1x50	Shared	15.7657	16.6322	Yes	Yes	No	No	5	7
58	8x50	I1x50	Shared	28.1026	17.3711	Yes	Yes	No	No	8	7
59	2x42	3x46	Shared	35.0403	63.7579	Yes	Yes	No	No	7	9
60	6x44	6x48	Shared	39.4127	44.1628	Yes	Yes	Yes	Yes	9	8
61	3x33	Lig	Shared	11.7451	13.769	No	No	Yes	Yes	4	0
62	5x58	6x37	Shared	12.5096	45.5593	Yes	Yes	No	No	9	8
63	3x51	5x57	Shared	17.0963	41.0928	Yes	Yes	No	No	7	8
64	6x51	6x52	Shared	21.0018	16.0004	No	Yes	No	No	6	7
65	6x51	Lig	Shared	22.1885	25.6502	No	Yes	Yes	Yes	6	0
66	5x47	6x52	Shared	11.8635	12.0992	Yes	No	No	No	8	7
67	E2	Lig	Shared	53.7711	37.9008	Yes	Yes	Yes	Yes	4	0
68	1x38	7x39	class-a_on	6.55386	13.407	No	No	No	No	4	5
69	1x39	7x39	class-a_on	7.70535	14.7074	Yes	Yes	No	No	7	5
70	3x36	6x48	class-a_on	1.31781	100	No	No	Yes	Yes	7	8
71	3x36	Lig	class-a_on	0	99.553	No	No	Yes	Yes	7	0
72	2x40	8x50	class-a_on	0	37.1952	Yes	Yes	Yes	Yes	8	8
73	2x37	2x40	class-a_on	1.53851	46.7526	No	No	Yes	Yes	7	8
74	2x37	2x38	class-a_on	0	48.441	No	No	No	No	7	6
75	2x38	I2x57	class-a_on	0	50.0924	No	No	No	No	6	0
76	3x49	I2x57	class-a_on	5.20407	52.3903	No	No	No	No	8	0
77	2x42	3x49	class-a_on	0	54.5109	Yes	Yes	No	No	7	8
78	3x46	7x53	class-a_on	0	47.3659	No	No	Yes	Yes	9	9
79	3x43	7x53	class-a_on	0	76.5701	No	No	Yes	Yes	8	9
80	3x43	7x49	class-a_on	0	53.8976	No	No	Yes	Yes	8	9
81	2x46	3x42	class-a_on	0	17.9585	No	Yes	No	No	9	8
82	E1x50	E1x52	class-a_on	7.85248	10.566	Yes	Yes	Yes	Yes	8	7
83	E1x51	E1x52	class-a_on	0	17.6962	No	No	Yes	Yes	4	7
84	E1x49	E1x51	class-a_on	1.74002	18.9634	No	No	No	No	4	4
85	E1x49	E2	class-a_on	2.62602	20.2453	No	No	Yes	Yes	4	4
86	3x33	4x57	class-a_on	1.71123	12.7752	No	No	No	No	4	7
87	3x50	5x58	class-a_on	0	31.3728	Yes	No	Yes	Yes	9	9
88	3x47	5x58	class-a_on	5.96213	49.1244	No	No	Yes	Yes	9	9
89	3x47	5x54	class-a_on	4.78186	46.5605	No	No	No	No	9	8
90	5x54	6x44	class-a_on	0	46.6935	No	No	Yes	Yes	8	9
91	3x47	5x57	class-a_on	0	45.2712	No	No	No	No	9	8
92	3x51	3x55	class-a_on	8.06679	26.9506	Yes	Yes	No	No	7	7
93	5x58	6x40	class-a_on	0	14.9291	Yes	Yes	No	No	9	8
94	6x40	7x53	class-a_on	0	14.9291	No	No	Yes	Yes	8	9
95	6x30	6x31	class-a_on	0	11.9107	No	Yes	Yes	No	7	4
96	5x66	6x30	class-a_on	0	35.614	No	No	No	Yes	5	7
97	5x62	5x66	class-a_on	1.20266	37.9673	No	Yes	No	No	5	5
98	5x62	6x37	class-a_on	0	44.6911	No	Yes	No	No	5	8
99	3x55	3x56	class-a_on	6.10606	16.3588	No	No	Yes	No	7	6
100	I2x52	I2x56	class-a_on	0	12.2765	No	No	No	No	4	7
101	3x56	I2x52	class-a_on	1.98311	14.8108	Yes	No	No	No	6	4
102	3x50	7x53	class-a_on	0	14.1348	Yes	No	Yes	Yes	9	9
103	5x69	6x30	class-a_on	0	22.6097	No	No	No	Yes	5	7
104	5x69	6x26	class-a_on	0	19.7835	No	No	No	Yes	5	5
105	5x73	6x26	class-a_on	0	11.3049	No	No	No	Yes	0	5
106	5x73	5x77	class-a_on	0	10.3628	No	No	No	Yes	0	0
107	2x46	2x50	class-a_on	0	12.3873	No	Yes	Yes	Yes	9	9
108	2x46	3x43	class-a_on	0	22.7169	No	Yes	No	No	9	8
109	3x46	3x50	class-a_on	0	17.1383	No	No	Yes	No	9	9

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

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2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
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A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
E3	NT	Shared	6.01857	2.57797	1	1	2	1
NT	NT	Shared	41.2837	21.7592	1	1	1	1
E2	NT	Shared	17.209	14.2351	1	1	1	1
7x31	NT	Shared	4.15425	2.27922	1	0	2	1
1x39	2x57	class-a_off	4.00921	0	1	0	2	2
1x39	7x42	Shared	3.82834	3.64046	1	0	2	1
2x57	7x42	Shared	5.76807	4.97709	1	0	2	1
2x60	3x28	Shared	4.0331	2.84693	1	1	1	2
3x25	E2	class-a_off	4.36986	0	1	3	2	1
3x26	E2	class-a_off	4.88139	0	1	0	2	1
3x32	Lig	Shared	9.02566	4.7046	1	1	1	0
3x33	4x57	Shared	3.9641	3.76972	1	1	1	2
3x33	Lig	Shared	4.92256	5.49817	1	1	1	0
3x36	6x48	Shared	6.43121	3.69395	0	1	1	1
3x40	6x44	Shared	7.27758	3.34756	0	1	2	2
4x60	5x39	Shared	7.14108	5.70727	0	1	2	2
5x39	E2	Shared	9.71503	6.81224	1	1	2	1
E2	E2x52	Shared	8.15674	5.45504	1	1	1	1
E2	E2	Shared	61.7577	51.5602	1	1	1	1
5x36	E2	Shared	12.1601	8.71361	0	0	2	1
E2	E2x51	Shared	9.60566	8.13219	1	1	1	1
7x34	E2	class-a_off	4.15192	0	1	1	1	1
E2	Lig	Shared	6.29933	8.97386	1	1	1	0
E2x52	Lig	Shared	5.08073	5.31405	1	1	1	0
6x58	E2	class-a_off	5.19326	0	1	0	2	1
6x44	6x48	Shared	10.9478	6.54846	1	1	2	1
6x48	7x41	Shared	6.82099	4.43188	1	1	1	2
6x48	7x45	Shared	6.50633	8.33812	1	1	1	2
6x48	Lig	class-a_off	4.91486	0	1	1	1	0
6x51	6x55	Shared	5.02913	5.18911	1	1	1	1
6x51	Lig	Shared	10.2896	6.92794	1	1	1	0
6x54	7x34	Shared	4.06778	3.46865	0	0	2	1
6x54	7x37	Shared	4.82534	3.53023	0	0	2	2
6x58	E3	class-a_off	3.92657	0	1	0	2	2
6x58	7x34	Shared	5.23936	3.15683	1	0	2	1
E3	E3	Shared	3.98594	4.49719	1	1	2	2
7x34	7x38	class-a_off	4.49532	0	1	1	1	1
7x42	Lig	Shared	4.12757	3.53104	1	1	1	0
7x38	Lig	Shared	7.44574	4.59984	1	0	1	0
2x60	Lig	Shared	6.28922	3.30617	1	1	1	0
3x29	Lig	class-a_off	6.11296	0	1	1	1	0
2x53	7x42	class-a_off	4.33563	0	0	0	2	1
3x22	E2	Shared	7.92607	5.91493	0	1	2	1
3x29	4x65	Shared	3.9534	3.92648	1	1	1	2
3x33	4x61	class-a_off	5.5726	0	1	1	1	2
4x64	E2	Shared	5.39826	6.78452	1	1	2	1
5x40	6x55	Shared	4.6763	3.48581	0	0	2	1
6x44	7x45	class-a_off	4.57774	0	1	1	2	2
6x55	Lig	class-a_off	4.18904	0	1	0	1	0
E1x49	E2	Shared	4.72576	2.8203	1	1	2	1
Lig	NT	Shared	5.62035	4.13514	1	1	0	1
5x39	5x43	Shared	3.8088	4.84101	1	1	2	1
3x37	5x43	Shared	3.66299	3.67829	0	0	2	1
6x51	6x52	Shared	3.40143	3.52684	1	1	1	2
1x32	NT	Shared	3.21609	2.03748	1	1	2	1
2x56	3x32	Shared	2.97232	3.79284	0	0	2	1
5x33	6x62	Shared	2.94339	1.00131	0	0	2	1
5x35	E2	Shared	2.81748	2.50066	1	1	2	1
5x32	5x35	class-a_off	2.10865	0	0	1	2	2
6x62	Lig	class-a_off	1.91407	0	1	1	1	0
4x63	E2	class-a_off	1.67537	0	0	0	2	1
5x38	E2	Shared	1.63788	1.64912	0	0	2	1
7x24	NT	Shared	1.14881	0.867405	0	0	2	1
4x68	E2	Shared	1.09257	0.32878	0	0	2	1
1x29	NT	class-a_off	0.99381	0	1	0	2	1
E1x501	NT	Shared	0.470929	0.293032	0	0	2	1
E1x48	NT	Shared	0.349786	0.115786	1	1	2	1
5x31	E2	class-a_off	0.291861	0	0	0	2	1
5x28	NT	class-a_off	0.0411429	0	0	1	2	1
2x68	E2	class-a_off	0.0339286	0	0	0	2	1
4x69	E2	Shared	0.0332	0.0218155	0	0	2	1
3x36	Lig	class-a_on	0	3.70192	0	1	1	0
3x40	6x48	class-a_on	0	8.37132	0	1	2	1
4x60	E2	class-a_on	0	4.34732	0	1	2	1
5x43	Lig	class-a_on	0	4.06925	0	1	1	0
6x51	7x37	class-a_on	0	3.3229	1	1	1	2
7x34	Lig	class-a_on	0	3.61643	1	1	1	0
E2x51	Lig	class-a_on	0	4.00829	0	1	1	0
3x22	3x26	class-a_on	0	2.86422	0	1	2	2
3x29	E2	class-a_on	0	2.36996	1	1	1	1
4x63	4x64	class-a_on	0	2.26901	0	0	2	2
7x28	NT	class-a_on	0	1.73986	0	1	2	1
7x32	NT	class-a_on	0	1.67842	0	1	2	1
6x62	E2	class-a_on	0	1.22464	1	1	1	1
5x32	E2	class-a_on	0	1.19552	0	1	2	1
5x31	5x35	class-a_on	0	0.666228	0	0	2	2
5x27	E2	class-a_on	0	0.056087	0	1	2	1
5x28	E2	class-a_on	0	0.0368219	0	1	2	1
3x29	Ca5	class-a_on	0	0.035646	1	1	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	class-a_off	sensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
	class-a_on	sensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on

Network Difference
Value	class-a_off	class-a_on
I_min	3.82493	3.30847
Number of Linked Nodes	336	372
Number of Specific Nodes	3 (0.89%)	39 (10.48%)
Number of Shared Nodes	333 (99.11%)	333 (89.52%)
Number of Links	352	387
Number of Specific Links	150 (42.61%)	185 (47.80%)
Number of Shared Links	202 (57.39%)	202 (52.20%)
Number of Hubs	34	33
Number of Specific Hubs	14 (41.18%)	13 (39.39%)
Number of Shared Hubs	20 (58.82%)	20 (60.61%)
Average % Shared Neighbours (Jaccard)	41.57
Average % Shared Neighbours (Otsuka)	48.74
Average % Shared Neighbours (Overlap Coefficient)	55.80
Average % Shared Cliques (k3-6)	80.77
Graphlets Similarity	0.381329

Paths Difference
Value	class-a_off	class-a_on
Number Of Nodes in MetaPath	67	59
Specific Nodes in MetaPath	31 (46.27%)	23 (38.98%)
Shared Nodes in MetaPath	333 (99.11%)	333 (99.11%)
Number Of Links MetaPath	67	62
Specific Links in MetaPath	47 (70.15%)	42 (67.74%)
Shared Links in MetaPath	202 (57.39%)	202 (57.39%)
Number of Shortest Paths	68055	60078
Length Of Smallest Path	3	3
Average Path Length	15.7677	13.5981
Length of Longest Path	34	29
Minimum Path Strength	0.619216	0.326937
Average Path Strength	4.51923	4.06584
Maximum Path Strength	14.6846	11.4744
Minimum Path Correlation	0.701756	0.702062
Average Path Correlation	0.888535	0.899444
Maximum Path Correlation	0.984253	0.987148
Minimum % Of Corr. Nodes	3.22581	3.7037
Average % Of Corr. Nodes	31.6811	37.1945
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	39.3846	37.1099
Maximum Path Hubs %	100	83.3333

Details about the values in these tables can be found in the corresponding documentation page .

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