Orange: nodes, hubs and links specific of class-c_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of class-c_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.


Index Hub Owner class-c_off Avg Int. Strength class-c_on Avg Int. Strength class-c_off Num Of Links class-c_on Num Of Links ConSurf
1R1.1x39 class-c_off00426
2R1.2x40 class-c_off41.66670539
3R1.2x56 class-c_off00418
4R1.3x21 class-c_off33.33330424
5R1.3x36 class-c_off16.666750439
6R1.3x51 class-c_off33.333350438
7R1.5x51 class-c_off050528
8R1.5x60 class-c_off33.33330528
9R1.6x48 class-c_off050538
10R1.6x58 class-c_off050436
11R1.7x39 class-c_off00427
12R2.1x39 class-c_off00435
13R2.1x60 class-c_off00434
14R2.I1x47 class-c_off16.66670525
15R2.2x47 class-c_off050437
16R2.2x60 class-c_off250435
17R2.3x30 class-c_off00416
18R2.3x43 class-c_off00418
19R2.3x49 class-c_off16.66670439
20R2.4x53 class-c_off83.33330439
21R2.5x57 class-c_off00439
22R2.5x60 class-c_off16.66670429
23R2.6x36 class-c_off16.66670526
24R2.6x51 class-c_off025417
25R2.E3 class-c_off16.66670434
26R1.NT Shared10010011126
27R1.2x54 Shared50100768
28R1.E1 Shared10075664
29R1.3x29 Shared33.33330555
30R1.3x40 Shared50100468
31R1.3x44 Shared16.66670549
32R1.3x46 Shared66.666750559
33R1.3x49 Shared5050649
34R1.4x53 Shared66.666712.5649
35R1.E2 Shared10010012144
36R1.5x46 Shared16.66670547
37R1.5x47 Shared500559
38R1.5x57 Shared00549
39R1.I3 Shared10010014107
40R1.6x33 Shared33.333350459
41R1.E3 Shared66.666750855
42R1.7x50 Shared00448
43R1.7x53 Shared41.666787.5879
44R2.NT Shared10010010116
45R2.1x35 Shared8.3333325445
46R2.2x40 Shared41.66670649
47R2.2x54 Shared100100878
48R2.E1 Shared100100875
49R2.3x36 Shared2525549
50R2.3x40 Shared66.666775578
51R2.4x64 Shared5050449
52R2.E2 Shared10010017154
53R2.E2x52 Shared00448
54R2.5x46 Shared00645
55R2.5x51 Shared33.333375558
56R2.I3 Shared1001001087
57R2.6x48 Shared5050547
58R2.7x32 Shared16.666712.5557
59R2.7x53 Shared91.666787.5789
60R1.1x60 class-c_on050345
61R1.2x42 class-c_on00346
62R1.2x44 class-c_on00248
63R1.2x46 class-c_on00147
64R1.3x28 class-c_on075258
65R1.3x30 class-c_on00346
66R1.3x38 class-c_on00357
67R1.3x52 class-c_on025146
68R1.I2 class-c_on050267
69R1.4x38 class-c_on00346
70R1.E2x51 class-c_on00245
71R1.5x44 class-c_on00156
72R1.6x41 class-c_on00248
73R1.6x42 class-c_on050249
74R1.6x51 class-c_on025348
75R1.7x35 class-c_on5050347
76R2.1x53 class-c_on00147
77R2.I1 class-c_on050146
78R2.2x49 class-c_on00349
79R2.2x57 class-c_on00248
80R2.3x28 class-c_on025247
81R2.I2 class-c_on050276
82R2.4x60 class-c_on050349
83R2.5x47 class-c_on00349
84R2.6x39 class-c_on050146
85R2.6x41 class-c_on33.333325359
86R2.6x47 class-c_on050347
87R2.7x30 class-c_on00145
88R2.7x33 class-c_on00146
89R1.Alloh56 class-c_on050060
90R1.Allo1 class-c_on16.666725150
   
Orange: nodes, hubs and links specific of class-c_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of class-c_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Owner class-c_off Recurrence class-c_on Recurrence class-c_off Hub1? class-c_on Hub1? class-c_off Hub2? class-c_on Hub2? ConSurf1 ConSurf2
1R1.2x50 R1.2x54 class-c_off10.94140NoNoYesYes58
2R1.7x521 R1.7x53 class-c_off36.2063.38688NoNoYesYes79
3R1.2x43 R1.7x521 class-c_off36.88690NoNoNoNo97
4R1.2x43 R1.3x46 class-c_off37.56671.14155NoNoYesYes99
5R1.3x46 R1.6x33 class-c_off22.18766.30145YesYesYesYes99
6R1.6x33 R1.I3 class-c_off22.78310YesYesYesYes97
7R1.3x54 R1.I3 class-c_off50.65133.23068NoNoYesYes87
8R1.3x54 R2.3x55 class-c_off50.8690NoNoNoNo87
9R1.5x60 R2.3x55 class-c_off51.08670YesNoNoNo87
10R1.3x51 R1.5x60 class-c_off59.16051.21187YesNoYesNo88
11R1.3x51 R1.5x57 class-c_off1004.57581YesNoYesYes89
12R1.3x44 R1.5x57 class-c_off95.82918.84291YesYesYesYes99
13R1.3x40 R1.3x44 class-c_off99.70480YesYesYesYes89
14R1.3x36 R1.5x47 class-c_off48.48920.0266509YesNoYesYes99
15R1.3x30 R1.4x57 class-c_off93.08930.487119NoYesNoNo68
16R1.3x30 R1.4x61 class-c_off92.2510NoYesNoNo66
17R1.3x26 R1.4x61 class-c_off91.83021.10083NoNoNoNo66
18R1.3x26 R1.E2 class-c_off91.40830NoNoYesYes64
19R1.3x46 R1.3x50 class-c_off22.11730YesYesNoNo99
20R1.3x50 R1.I3 class-c_off22.43321.76266NoNoYesYes97
21R1.5x46 R1.5x50 class-c_off47.51130YesYesNoNo78
22R1.4x53 R1.5x46 class-c_off46.76732.73838YesYesYesYes97
23R1.1x57 R1.7x53 class-c_off10.94143.96136NoNoYesYes99
24R1.1x57 R1.2x44 class-c_off10.22760NoNoNoYes98
25R2.5x53 R2.5x57 class-c_off49.06011.13488NoNoYesNo79
26R2.3x51 R2.5x57 class-c_off55.68390NoNoYesNo89
27R1.5x60 R2.3x51 class-c_off30.03870YesNoNoNo88
28R2.3x51 R2.5x60 class-c_off26.16987.80278NoNoYesNo89
29R1.3x51 R2.5x60 class-c_off40.81440YesNoYesNo89
30R2.E1 R2.NT class-c_off11.88083.4202YesYesYesYes56
31R2.7x32 R2.NT class-c_off11.50188.56974YesYesYesYes76
32R2.5x60 R2.5x61 class-c_off28.97660YesNoNoNo99
33R2.3x50 R2.5x61 class-c_off27.99820NoNoNoNo99
34R2.3x50 R2.I3 class-c_off27.65721.09787NoNoYesYes97
35R2.6x33 R2.I3 class-c_off21.56144.38777NoNoYesYes97
36R2.6x33 R2.6x37 class-c_off21.44873.29286NoNoNoNo98
37R2.3x46 R2.6x37 class-c_off21.08640NoNoNoNo98
38R2.3x46 R2.I1x53 class-c_off10.65790NoNoNoNo99
39R2.7x56 R2.I1x53 class-c_off10.28340.569292NoNoNoNo99
40R2.3x44 R2.5x53 class-c_off47.90980NoNoNoNo97
41R2.3x40 R2.3x44 class-c_off42.06070.438259YesYesNoNo89
42R2.3x36 R2.3x40 class-c_off15.25851.37326YesYesYesYes98
43R2.3x40 R2.5x50 class-c_off12.11290.552265YesYesNoNo88
44R2.5x46 R2.5x50 class-c_off10.83480.014806YesYesNoNo58
45R2.3x21 R2.3x24 class-c_off17.61880.573734NoNoNoNo44
46R2.2x59 R2.3x24 class-c_off15.27250NoNoNoNo64
47R2.2x59 R2.3x28 class-c_off12.92173.2751NoNoNoYes67
48R2.2x60 R2.3x28 class-c_off11.74464.36408YesNoNoYes57
49R1.E2 R1.E3 class-c_off16.05221.97809YesYesYesYes45
50R1.2x50 R1.7x50 Shared12.390911.9751NoNoYesYes58
51R1.7x50 R1.7x53 Shared17.399511.5332YesYesYesYes89
52R1.3x36 R1.3x40 Shared49.638918.264YesNoYesYes98
53R1.4x53 R1.5x47 Shared47.884737.6503YesYesYesYes99
54R1.4x53 R1.4x57 Shared93.506845.5952YesYesNoNo98
55R1.E2 R1.NT Shared57.717286.5805YesYesYesYes46
56R1.3x40 R1.5x50 Shared47.665914.2819YesYesNoNo88
57R1.NT R2.NT Shared56.3124100YesYesYesYes66
58R2.2x42 R2.3x46 Shared10.133827.9338NoNoNoNo69
59R2.E2 R2.NT Shared30.191128.6267YesYesYesYes46
60R1.1x36 R1.1x40 class-c_on017.8294NoNoNoNo53
61R1.1x36 R1.NT class-c_on1.2016418.2499NoNoYesYes56
62R1.1x43 R1.2x58 class-c_on1.8579916.3851NoNoNoNo75
63R1.1x40 R1.2x58 class-c_on1.2395917.5281NoNoNoNo35
64R1.1x43 R1.2x54 class-c_on015.0259NoNoYesYes78
65R1.2x50 R1.7x46 class-c_on0.72890912.6384NoNoNoNo58
66R1.2x54 R1.7x46 class-c_on0.0078137212.8124YesYesNoNo88
67R1.3x46 R1.I3 class-c_on019.4773YesYesYesYes97
68R1.3x46 R1.6x37 class-c_on042.2594YesYesNoNo99
69R1.3x43 R1.6x37 class-c_on043.3232NoNoNoNo99
70R1.3x43 R1.6x41 class-c_on1.4176350.4523NoNoNoYes98
71R1.3x40 R1.6x41 class-c_on054.37YesYesNoYes88
72R1.3x36 R1.Allo1 class-c_on0.33654818.4431YesNoNoYes90
73R1.5x40 R1.Allo1 class-c_on038.6127NoNoNoYes50
74R1.5x36 R1.5x40 class-c_on040.6678NoNoNoNo55
75R1.5x36 R1.E2x51 class-c_on0.61895840.7751NoNoNoYes55
76R1.E2 R1.E2x51 class-c_on1.2373665.0725YesYesNoYes45
77R1.3x40 R1.5x47 class-c_on055.5301YesYesYesYes89
78R1.5x47 R1.Allo1 class-c_on018.8059YesYesNoYes90
79R1.3x29 R1.4x57 class-c_on045.6063YesYesNoNo58
80R1.3x29 R1.E2x51 class-c_on024.3937YesYesNoYes55
81R1.3x29 R1.4x61 class-c_on024.2738YesYesNoNo56
82R1.4x61 R1.E2 class-c_on025.5056NoNoYesYes64
83R1.2x42 R1.3x46 class-c_on5.8664318.8518NoYesYesYes69
84R1.2x42 R1.4x42 class-c_on014.6232NoYesNoNo68
85R1.3x44 R1.5x50 class-c_on013.1633YesYesNoNo98
86R1.3x49 R1.4x42 class-c_on0.47440413.4898YesYesNoNo98
87R1.6x42 R2.6x43 class-c_on010.1377NoYesNoNo99
88R2.6x43 R2.7x48 class-c_on0.66416621.2718NoNoNoNo94
89R2.7x44 R2.7x48 class-c_on021.7826NoNoNoNo44
90R2.6x47 R2.7x44 class-c_on022.2912NoYesNoNo74
91R2.6x47 R2.7x45 class-c_on6.5964624.7557NoYesNoNo77
92R2.6x48 R2.7x45 class-c_on025.2561YesYesNoNo77
93R2.3x36 R2.6x48 class-c_on4.5509325.9935YesYesYesYes97
94R2.3x36 R2.5x51 class-c_on0.055254228.8052YesYesYesYes98
95R2.5x51 R2.6x41 class-c_on042.2105YesYesNoYes89
96R2.6x40 R2.6x41 class-c_on046.9662NoNoNoYes89
97R2.6x40 R2.7x521 class-c_on047.8205NoNoNoNo88
98R2.7x521 R2.7x53 class-c_on0.42584848.2455NoNoYesYes89
99R2.7x50 R2.7x53 class-c_on0.41524373.2099NoNoYesYes79
100R2.2x50 R2.7x50 class-c_on073.5342NoNoNoNo57
101R2.2x50 R2.2x54 class-c_on0.42584873.7333NoNoYesYes58
102R2.1x43 R2.2x54 class-c_on077.3097NoNoYesYes78
103R2.1x43 R2.2x57 class-c_on3.0691278.82NoNoNoYes78
104R2.2x57 R2.7x39 class-c_on3.679780.0015NoYesNoNo86
105R2.1x39 R2.7x39 class-c_on4.8975380.2932YesNoNoNo56
106R2.1x39 R2.7x35 class-c_on081.4451YesNoNoNo57
107R2.7x35 R2.NT class-c_on081.7293NoNoYesYes76
108R2.6x39 R2.6x43 class-c_on0.66416610.6189NoYesNoNo69
109R2.3x53 R2.I2 class-c_on011.5369NoNoNoYes86
110R2.3x49 R2.3x53 class-c_on012.0743YesNoNoNo98
111R2.3x49 R2.4x42 class-c_on1.9902724.4618YesNoNoNo98
112R2.2x42 R2.4x42 class-c_on026.4547NoNoNoNo68
113R2.2x43 R2.3x46 class-c_on028.4239NoNoNoNo99
114R2.2x43 R2.7x53 class-c_on0.42584828.9125NoNoYesYes99
115R2.2x39 R2.3x49 class-c_on012.631NoNoYesNo99
116R2.2x39 R2.2x40 class-c_on012.0951NoNoYesYes99
117R1.Alloh56 R2.6x35 class-c_on011.87NoYesNoNo08
118R2.3x40 R2.5x51 class-c_on7.0089112.0721YesYesYesYes88
119R2.3x40 R2.5x46 class-c_on011.6124YesYesYesYes85
120R2.4x53 R2.5x46 class-c_on5.7659710.0067YesNoYesYes95

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Midway



Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Node1Node2OwnerNet1LinkStrengthNet2LinkStrengthComm1Comm2Node1ShellNode2Shell
R1.NTR1.NTShared3264.233639.861122
R1.NTR2.NTShared106.746219.2621121
R2.NTR2.NTShared3182.023587.321111
R2.E2R2.NTShared62.860875.72251121
R2.E1R2.NTShared12.53088.516251121
R2.7x31R2.NTShared3.286.646251121
R2.7x32R2.NTShared6.313.89251121
R2.1x33R2.E1class-c_off2.6383300022
R2.2x61R2.7x35class-c_off2.91167012022
R2.E1R2.E1Shared9.9941717.481122
R2.E2R2.E2Shared102.093100.1561122
R2.E1R2.E2Shared4.284173.371251122
R2.LigR2.NTShared36.539.54870001
R2.7x31R2.7x32Shared2.743332.58751122
R2.1x36R2.NTclass-c_off2.1283300021
R2.1x34R2.NTclass-c_off1.8783300021
R2.2x61R2.NTclass-c_on02.71512021
R2.7x35R2.NTclass-c_on03.0812121
R2.7x31R2.E2class-c_on08.316251122
R2.7x32R2.E2class-c_on04.92251122
R2.1x33R2.NTclass-c_on01.340021

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

2D representation of the interactions of this orthosteric/allosteric ligand.


Node1Node2OwnerNet1LinkStrengthNet2LinkStrengthComm1Comm2Node1ShellNode2Shell
R1.NTR1.NTShared3264.233639.861111
R1.LigR1.NTShared74.613380.60620001
R1.NTR2.NTShared106.746219.2621112
R1.E2R1.NTShared74.712579.1451121
R1.E1R1.NTShared22.895825.9551121
R1.1x36R1.NTShared4.491672.82751121
R1.E3R1.NTShared3.45758.0051121
R1.E1R1.E1Shared14.02428.973751122
R1.E1R1.E2Shared8.7941711.171122
R1.E2R1.E2Shared96.7083102.2211122
R1.E2R1.E3Shared3.553337.741122
R1.E3R1.E3Shared4.468335.5451122
R2.NTR2.NTShared3182.023587.321122
R1.7x31R1.NTclass-c_off3.42500021
R1.7x32R1.E3class-c_off4.4583301122
R1.1x34R1.NTclass-c_off2.3301021
R1.1x33R1.NTShared0.8983330.621250021
R1.7x35R1.NTclass-c_on08.383750121
R1.7x32R1.NTclass-c_on03.89751121
R1.7x31R1.E2class-c_on06.1750022
R1.7x32R1.E2class-c_on02.76251122
R1.7x35R1.E2class-c_on03.7550122
R1.1x32R1.NTclass-c_on00.61750021

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

2D representation of the interactions of this orthosteric/allosteric ligand.


Node1Node2OwnerNet1LinkStrengthNet2LinkStrengthComm1Comm2Node1ShellNode2Shell
R1.3x36R1.3x40Shared3.611675.88250412
R1.3x36R1.5x47Shared7.59754.776250411
R1.3x36R1.6x48class-c_off4.5058300412
R1.4x53R1.5x43class-c_off2.4466706422
R1.4x53R1.5x46Shared7.3656.198756422
R1.4x53R1.5x47Shared5.666675.3356421
R1.5x43R1.5x47class-c_off3.106021
R1.5x44R1.6x52Shared3.16251.853750412
R1.5x46R1.5x47Shared4.371675.0656421
R1.3x29R1.5x40class-c_off5.4808301121
R1.6x48R1.6x52class-c_off4.1766700022
R1.6x55R1.7x34Shared7.831676.69750012
R1.6x55R1.7x38class-c_off2.2600012
R1.5x40R1.6x56class-c_off2.08500412
R1.5x37R1.5x40class-c_off1.6133300021
R1.3x36R1.Allo1Shared1.523.736250410
R1.6x55R1.6x59class-c_off1.3216700012
R1.3x33R1.5x47class-c_off0.98833300021
R1.5x36R1.5x40class-c_on02.8250021
R1.5x37R1.6x56class-c_on02.8050022
R1.5x40R1.5x44class-c_on07.0350411
R1.6x51R1.6x55class-c_on04.803750021
R1.3x40R1.5x47class-c_on03.043750421
R1.5x40R1.Allo1class-c_on03.08250410
R1.5x44R1.Allo1class-c_on02.593750410
R1.5x47R1.Allo1class-c_on02.576256410
R1.6x48R1.6x51class-c_on02.630022
R1.6x55R1.Allo1class-c_on02.640010
R1.3x40R1.6x48class-c_on02.77250422
R1.6x59R1.7x34class-c_on02.1650022
R1.5x44R1.5x48class-c_on01.953750412
R1.5x44R1.5x45class-c_on01.15250412

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
Id Description
class-c_off gabab_off
mglu_off
class-c_on gabab_on
mglu_on
Network Difference
Value class-c_off class-c_on
Imin 2.3525 2.53625
Number of Linked Nodes 457 478
Number of Specific Nodes 3 (0.66%) 24  (5.02%)
Number of Shared Nodes 454 (99.34%) 454  (94.98%)
Number of Links 507 539
Number of Specific Links 244 (48.13%) 276  (51.21%)
Number of Shared Links 263 (51.87%) 263  (48.79%)
Number of Hubs 59 65
Number of Specific Hubs 25 (42.37%) 31  (47.69%)
Number of Shared Hubs 34 (57.63%) 34  (52.31%)
Average % Shared Neighbours (Jaccard) 34.46
Average % Shared Neighbours (Otsuka) 43.87
Average % Shared Neighbours (Overlap Coefficient) 52.95
Average % Shared Cliques (k3-6) 53.70
Graphlets Similarity 0.558642
Paths Difference
Value class-c_off class-c_on
Number Of Nodes in MetaPath 58 70
Specific Nodes in MetaPath 35 (60.34%) 47  (67.14%)
Shared Nodes in MetaPath 454 (99.34%) 454  (99.34%)
Number Of Links MetaPath 59 71
Specific Links in MetaPath 49 (83.05%) 61  (85.92%)
Shared Links in MetaPath 263 (51.87%) 263  (51.87%)
Number of Shortest Paths 259265 217901
Length Of Smallest Path 3 3
Average Path Length 22.0788 21.1219
Length of Longest Path 41 46
Minimum Path Strength 0.581667 0.4475
Average Path Strength 7.58122 13.7731
Maximum Path Strength 64.6631 113.889
Minimum Path Correlation 0.7125 0.7
Average Path Correlation 0.972127 0.972949
Maximum Path Correlation 1 1
Minimum % Of Corr. Nodes 3.44828 2.38095
Average % Of Corr. Nodes 56.1238 60.9548
Maximum % Of Corr. Nodes 100 100
Minimum Path Hubs % 0 0
Average Path Hubs % 49.2696 45.9617
Maximum Path Hubs % 100 100

Details about the values in these tables can be found in the corresponding documentation page .

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