psnGPCR

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Orange: nodes, hubs and links specific of cxcr3_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of cxcr3_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	cxcr3_off Int. Strength	cxcr3_on Int. Strength	cxcr3_off Hub1?	cxcr3_on Hub1?	cxcr3_off Hub2?	cxcr3_on Hub2?	ConSurf1	ConSurf2
1	1x35	Lig	cxcr3_off	5.88	0	No	Yes	Yes	Yes	5	0
2	1x36	2x64	cxcr3_off	3.74	0	No	No	No	No	4	5
3	1x43	2x57	cxcr3_off	3.65	0	No	No	No	No	7	8
4	1x45	7x47	cxcr3_off	6.35	0	No	No	No	No	6	8
5	1x49	7x50	cxcr3_off	4.06	0	No	No	No	No	7	9
6	1x57	1x60	cxcr3_off	3.64	0	No	Yes	Yes	Yes	7	5
7	1x60	2x40	cxcr3_off	5.96	0	Yes	Yes	Yes	Yes	5	8
8	2x37	2x39	cxcr3_off	4.8	0	No	No	Yes	No	7	8
9	2x37	I2x55	cxcr3_off	3.95	0	No	No	No	No	7	4
10	2x38	2x39	cxcr3_off	3.2	0	No	No	Yes	No	6	8
11	2x38	I2x54	cxcr3_off	6.36	0	No	No	Yes	No	6	5
12	2x39	3x46	cxcr3_off	4.56	0	Yes	No	No	No	8	9
13	2x39	3x50	cxcr3_off	2.59	0	Yes	No	No	No	8	9
14	2x41	2x42	cxcr3_off	2.59	0	No	No	Yes	Yes	6	7
15	2x42	3x42	cxcr3_off	2.44	0	Yes	Yes	No	No	7	8
16	2x42	I2x54	cxcr3_off	4.13	0	Yes	Yes	Yes	No	7	5
17	2x43	7x53	cxcr3_off	4.69	0	No	No	Yes	Yes	8	9
18	2x50	3x35	cxcr3_off	5.39	0	Yes	Yes	Yes	Yes	9	8
19	2x51	2x54	cxcr3_off	3.17	0	No	No	No	No	7	6
20	2x52	3x31	cxcr3_off	4.15	0	No	No	No	No	5	5
21	2x53	7x42	cxcr3_off	8.21	0	No	No	Yes	Yes	6	6
22	2x53	7x46	cxcr3_off	4.76	0	No	No	No	No	6	8
23	2x54	2x57	cxcr3_off	2.98	0	No	No	No	No	6	8
24	2x56	7x42	cxcr3_off	2.5	0	No	No	Yes	Yes	7	6
25	2x59	E1x50	cxcr3_off	5.69	0	No	No	Yes	Yes	6	9
26	2x59	3x24	cxcr3_off	4.15	0	No	No	No	No	6	6
27	2x60	2x63	cxcr3_off	3.35	0	Yes	Yes	No	No	5	5
28	2x60	E1x50	cxcr3_off	8.43	0	Yes	Yes	Yes	Yes	5	9
29	2x60	7x42	cxcr3_off	4.82	0	Yes	Yes	Yes	Yes	5	6
30	E1x49	E2.A200	cxcr3_off	3.03	0	No	No	No	No	3	1
31	E1x49	E2.T201	cxcr3_off	8.5	0	No	No	No	No	3	5
32	E1x50	E2.T201	cxcr3_off	3.64	0	Yes	Yes	No	No	9	5
33	3x27	3x31	cxcr3_off	2.98	0	No	No	No	No	5	5
34	3x32	6x48	cxcr3_off	5.01	0	Yes	Yes	Yes	Yes	5	9
35	3x32	6x51	cxcr3_off	5.16	0	Yes	Yes	Yes	Yes	5	6
36	3x32	7x38	cxcr3_off	2.64	0	Yes	Yes	No	No	5	5
37	3x33	3x36	cxcr3_off	6.04	0	No	No	Yes	No	4	7
38	3x34	4x50	cxcr3_off	3.52	0	No	No	No	No	6	9
39	3x35	6x48	cxcr3_off	3.39	0	Yes	Yes	Yes	Yes	8	9
40	3x35	7x46	cxcr3_off	4.72	0	Yes	Yes	No	No	8	8
41	3x36	5x43	cxcr3_off	8.2	0	Yes	No	No	No	7	5
42	3x36	6x52	cxcr3_off	9.05	0	Yes	No	No	No	7	8
43	3x39	6x44	cxcr3_off	3.01	0	No	No	Yes	Yes	9	9
44	3x40	5x50	cxcr3_off	3.74	0	No	No	Yes	No	8	9
45	3x43	6x41	cxcr3_off	7.45	0	Yes	No	No	No	8	8
46	3x43	6x44	cxcr3_off	6.09	0	Yes	No	Yes	Yes	8	9
47	3x46	6x37	cxcr3_off	3.07	0	No	No	No	No	9	7
48	3x48	3x51	cxcr3_off	3.09	0	No	No	Yes	Yes	6	8
49	3x48	5x57	cxcr3_off	2.79	0	No	No	No	No	6	7
50	3x49	I2x54	cxcr3_off	9.2	0	No	Yes	Yes	No	8	5
51	3x50	3x53	cxcr3_off	4.82	0	No	No	No	No	9	8
52	3x50	6x37	cxcr3_off	6.54	0	No	No	No	No	9	7
53	3x51	3x52	cxcr3_off	4.69	0	Yes	Yes	Yes	No	8	5
54	3x51	5x56	cxcr3_off	2.98	0	Yes	Yes	No	No	8	4
55	3x51	5x61	cxcr3_off	3.63	0	Yes	Yes	No	No	8	8
56	3x52	3x56	cxcr3_off	3.86	0	Yes	No	No	No	5	6
57	3x52	I2x51	cxcr3_off	5.9	0	Yes	No	No	No	5	5
58	3x53	I2x52	cxcr3_off	2.64	0	No	No	No	No	8	4
59	3x54	3x55	cxcr3_off	3.07	0	No	No	No	No	8	7
60	3x56	I2x51	cxcr3_off	2.74	0	No	No	No	No	6	5
61	I2x51	I2x53	cxcr3_off	2.95	0	No	No	No	No	5	6
62	I2x52	I2x55	cxcr3_off	5.84	0	No	No	No	No	4	4
63	4x41	I2x54	cxcr3_off	3.09	0	No	No	Yes	No	4	5
64	4x42	I2x54	cxcr3_off	5.05	0	Yes	No	Yes	No	8	5
65	4x45	I2x54	cxcr3_off	2.5	0	No	No	Yes	No	5	5
66	4x42	4x45	cxcr3_off	3.17	0	Yes	No	No	No	8	5
67	4x60	5x39	cxcr3_off	3.28	0	No	No	No	No	7	5
68	E2.H193	E2.N206	cxcr3_off	15.31	0	No	No	No	No	3	4
69	E2.D195	E2.L198	cxcr3_off	8.14	0	No	No	No	No	2	1
70	5x36	E2x52	cxcr3_off	7.2	0	No	No	Yes	Yes	4	3
71	5x36	E2.F207	cxcr3_off	9.62	0	No	No	Yes	Yes	4	4
72	5x40	6x62	cxcr3_off	9.53	0	Yes	Yes	No	No	3	2
73	5x41	6x59	cxcr3_off	3.07	0	No	No	Yes	No	4	5
74	5x43	6x52	cxcr3_off	3.71	0	No	No	No	No	5	8
75	5x44	5x47	cxcr3_off	2.44	0	No	No	Yes	Yes	4	8
76	5x44	6x59	cxcr3_off	2.85	0	No	No	Yes	No	4	5
77	5x54	6x41	cxcr3_off	3.04	0	No	No	No	No	8	8
78	6x35	7x56	cxcr3_off	3.92	0	No	No	Yes	No	5	7
79	6x36	7x53	cxcr3_off	8.21	0	No	No	Yes	Yes	8	9
80	6x51	7x38	cxcr3_off	3.82	0	Yes	Yes	No	No	6	5
81	6x54	7x34	cxcr3_off	4.55	0	No	No	No	No	4	5
82	6x55	6x59	cxcr3_off	3.07	0	No	No	Yes	No	5	5
83	6x58	6x61	cxcr3_off	4.16	0	No	Yes	Yes	No	5	3
84	6x60	E3.A285	cxcr3_off	4.73	0	No	No	No	No	4	1
85	6x61	E3.R288	cxcr3_off	8.69	0	Yes	No	No	No	3	4
86	6x61	7x30	cxcr3_off	3.04	0	Yes	No	No	No	3	4
87	6x62	E3.R288	cxcr3_off	7.15	0	No	No	No	No	2	4
88	7x26	E3.L286	cxcr3_off	6.07	0	No	No	No	No	3	1
89	7x23	7x24	cxcr3_off	4.72	0	No	No	No	No	5	8
90	7x23	7x25	cxcr3_off	5.09	0	No	No	No	No	5	2
91	7x27	7x30	cxcr3_off	4.28	0	No	Yes	No	No	1	4
92	7x27	7x31	cxcr3_off	6.5	0	No	Yes	No	No	1	4
93	7x34	Lig	cxcr3_off	4.99	0	No	No	Yes	Yes	5	0
94	7x35	Lig	cxcr3_off	15.95	0	No	No	Yes	Yes	4	0
95	7x53	8x50	cxcr3_off	15.47	0	Yes	Yes	Yes	Yes	9	8
96	7x53	8x53	cxcr3_off	3.09	0	Yes	Yes	Yes	Yes	9	5
97	8x48	8x52	cxcr3_off	2.85	0	No	No	No	No	5	5
98	8x50	8x53	cxcr3_off	7.48	0	Yes	Yes	Yes	Yes	8	5
99	4x41	I2x53	cxcr3_off	2.43	0	No	No	No	No	4	6
100	7x39	Lig	cxcr3_off	2.42	0	No	No	Yes	Yes	5	0
101	3x38	3x39	cxcr3_off	1.95	0	No	No	No	No	7	9
102	5x46	5x461	cxcr3_off	1.95	0	No	No	No	No	5	5
103	4x40	I2.P164	cxcr3_off	1.87	0	No	No	Yes	No	4	6
104	7x25	7x28	cxcr3_off	1.86	0	No	No	No	No	2	3
105	3x30	4x57	cxcr3_off	1.79	0	No	No	No	No	5	7
106	1x53	7x50	cxcr3_off	1.77	0	No	No	No	No	9	9
107	7x40	7x41	cxcr3_off	1.71	0	No	No	No	No	8	8
108	2x65	2x66	cxcr3_off	1.7	0	No	No	No	No	5	4
109	3x22	E2.S191	cxcr3_off	1.63	0	No	No	No	No	3	4
110	1x52	8x54	cxcr3_off	1.61	0	No	No	Yes	No	7	6
111	6x38	6x42	cxcr3_off	1.6	0	No	No	No	No	5	5
112	6x39	7x56	cxcr3_off	1.6	0	No	No	Yes	No	5	7
113	6x57	7x30	cxcr3_off	1.6	0	No	No	No	No	5	4
114	7x32	7x36	cxcr3_off	1.6	0	No	No	No	No	2	6
115	4x42	4x43	cxcr3_off	1.59	0	Yes	No	No	No	8	4
116	5x37	5x41	cxcr3_off	1.59	0	No	No	No	No	1	4
117	6x47	7x48	cxcr3_off	1.59	0	No	No	No	No	9	6
118	I2x56	I2x57	cxcr3_off	1.5	0	No	No	No	No	4	6
119	3x43	6x40	cxcr3_off	1.49	0	Yes	No	No	No	8	8
120	6x40	7x52	cxcr3_off	1.49	0	No	No	No	No	8	8
121	4x43	4x47	cxcr3_off	1.47	0	No	No	No	No	4	5
122	4x41	I2.P164	cxcr3_off	1.44	0	No	No	Yes	No	4	6
123	5x33	5x37	cxcr3_off	1.42	0	No	No	No	No	2	1
124	3x26	4x65	cxcr3_off	1.41	0	No	No	No	No	7	5
125	1x44	1x48	cxcr3_off	1.38	0	No	No	No	No	5	5
126	5x51	5x52	cxcr3_off	1.38	0	No	No	No	No	7	4
127	7x28	7x29	cxcr3_off	1.32	0	No	No	No	No	3	3
128	I1x48	I1x49	cxcr3_off	1.29	0	No	No	No	No	5	6
129	E2.L198	E2.R197	cxcr3_off	1.21	0	No	No	No	No	1	4
130	E2.E196	E2.R197	cxcr3_off	1.16	0	No	No	No	No	1	4
131	8x51	8x52	cxcr3_off	1.16	0	No	No	No	No	8	5
132	7x32	Lig	cxcr3_off	1.06	0	No	No	Yes	Yes	2	0
133	1x34	1x38	Shared	3.65	3.655	No	No	No	No	4	6
134	1x35	1x39	Shared	9.38	9.38	No	Yes	Yes	Yes	5	8
135	1x38	1x39	Shared	3.52	4.1	No	No	Yes	Yes	6	8
136	1x38	1x42	Shared	4.15	6.225	No	No	No	No	6	7
137	1x39	2x61	Shared	2.67	4	Yes	Yes	No	No	8	7
138	1x39	Lig	Shared	15.78	6.315	Yes	Yes	Yes	Yes	8	0
139	1x42	7x43	Shared	2.83	2.83	No	No	No	No	7	5
140	1x43	1x47	Shared	3.65	9.745	No	No	No	No	7	6
141	1x43	2x58	Shared	8.67	8.67	No	No	No	No	7	9
142	1x50	2x50	Shared	5.39	6.73	No	No	Yes	Yes	9	9
143	1x50	2x51	Shared	4.39	5.12	No	No	No	No	9	7
144	1x53	8x50	Shared	5.24	6.55	No	No	Yes	Yes	9	8
145	1x56	8x50	Shared	2.62	9.18	No	No	Yes	Yes	7	8
146	1x56	8x54	Shared	6.09	4.56	No	No	Yes	No	7	6
147	1x57	2x40	Shared	2.71	2.715	No	Yes	Yes	Yes	7	8
148	1x57	2x44	Shared	4.15	2.77	No	Yes	Yes	Yes	7	6
149	1x58	I1x48	Shared	4.86	1.82	No	No	No	No	4	5
150	1x58	2x44	Shared	4.15	2.77	No	No	Yes	Yes	4	6
151	1x59	1x60	Shared	2.64	3.295	No	No	Yes	Yes	5	5
152	1x60	8x53	Shared	11.73	2.13	Yes	Yes	Yes	Yes	5	5
153	2x40	I1x51	Shared	5.43	6.11	Yes	Yes	No	No	8	6
154	2x41	I1x51	Shared	2.95	2.95	No	No	No	No	6	6
155	2x37	2x40	Shared	5.89	8.83	No	No	Yes	Yes	7	8
156	2x38	3x49	Shared	4.42	7.36	No	No	No	Yes	6	8
157	2x41	4x42	Shared	7.93	4.76	No	No	Yes	No	6	8
158	2x42	3x45	Shared	2.79	4.89	Yes	Yes	No	No	7	7
159	2x42	3x46	Shared	12.56	3.77	Yes	Yes	No	No	7	9
160	2x42	4x42	Shared	5.24	3.93	Yes	Yes	Yes	No	7	8
161	2x42	4x45	Shared	2.59	5.84	Yes	Yes	No	No	7	5
162	2x42	4x46	Shared	2.79	4.19	Yes	Yes	No	No	7	7
163	2x45	4x46	Shared	14.74	14.005	No	No	No	No	9	7
164	2x45	4x50	Shared	6.35	7.41	No	No	No	No	9	9
165	2x46	3x42	Shared	4.15	3.46	No	Yes	No	No	9	8
166	2x46	3x43	Shared	2.77	3.46	No	Yes	Yes	No	9	8
167	2x49	4x50	Shared	2.59	1.945	No	No	No	No	8	9
168	2x50	7x46	Shared	9.34	3.89	Yes	Yes	No	No	9	8
169	2x50	7x49	Shared	4.04	7.405	Yes	Yes	No	Yes	9	9
170	2x53	3x35	Shared	13.73	7.555	No	No	Yes	Yes	6	8
171	2x56	2x60	Shared	3.64	5.455	No	No	Yes	Yes	7	5
172	2x57	7x42	Shared	4.69	4.685	No	No	Yes	Yes	8	6
173	2x59	E1x52	Shared	12.18	4.265	No	No	Yes	Yes	6	7
174	2x60	3x28	Shared	3.89	3.89	Yes	Yes	No	No	5	5
175	2x60	Lig	Shared	22.59	25.48	Yes	Yes	Yes	Yes	5	0
176	2x62	E1x52	Shared	6.55	4.585	No	No	Yes	Yes	4	7
177	2x63	E1x50	Shared	10.05	10.05	No	No	Yes	Yes	5	9
178	E1x49	E1x51	Shared	4.3	2.865	No	No	No	No	3	3
179	E1x50	E1x52	Shared	18.04	12.525	Yes	Yes	Yes	Yes	9	7
180	3x25	E1x50	Shared	3.92	5.88	No	No	Yes	Yes	9	9
181	E1x50	E2x50	Shared	7.84	3.915	Yes	Yes	No	No	9	9
182	3x24	E1x52	Shared	2.44	5.48	No	No	Yes	Yes	6	7
183	3x22	3x26	Shared	4.59	0.765	No	No	No	No	3	7
184	3x23	3x26	Shared	3.49	2.615	No	No	No	No	1	7
185	3x25	E2x50	Shared	5.46	7.28	No	No	No	No	9	9
186	3x30	4x62	Shared	5.55	5.55	No	No	No	No	5	4
187	3x32	7x42	Shared	8.25	8.77	Yes	Yes	Yes	Yes	5	6
188	3x33	4x61	Shared	9.42	10.77	No	No	No	Yes	4	4
189	3x34	4x57	Shared	3.25	3.25	No	No	No	No	6	7
190	3x36	3x37	Shared	7.22	3.61	Yes	No	Yes	Yes	7	6
191	3x36	6x48	Shared	11.02	7.015	Yes	No	Yes	Yes	7	9
192	3x37	4x53	Shared	2.69	2.69	Yes	Yes	No	No	6	8
193	3x37	4x56	Shared	7.22	7.225	Yes	Yes	No	Yes	6	5
194	3x37	5x43	Shared	5.64	3.945	Yes	Yes	No	No	6	5
195	3x41	4x49	Shared	4.47	4.47	No	No	No	No	6	7
196	3x42	4x49	Shared	4.47	2.235	No	No	No	No	8	7
197	3x47	5x54	Shared	6.13	6.13	No	No	No	No	9	8
198	3x47	5x58	Shared	10.17	10.17	No	No	No	Yes	9	8
199	3x48	3x52	Shared	6.09	5.48	No	No	Yes	No	6	5
200	3x51	3x55	Shared	6.31	11.36	Yes	Yes	No	No	8	7
201	3x51	5x57	Shared	9.41	7.39	Yes	Yes	No	No	8	7
202	3x51	5x60	Shared	8.71	4.9	Yes	Yes	No	No	8	4
203	3x52	I2x53	Shared	2.77	2.77	Yes	No	No	No	5	6
204	3x54	5x61	Shared	5.89	4.415	No	No	No	No	8	8
205	3x55	3x56	Shared	4.15	4.15	No	No	No	No	7	6
206	I2.P164	I2x57	Shared	4.06	4.06	Yes	No	No	No	6	6
207	4x52	4x56	Shared	6.09	7.305	No	No	No	Yes	4	5
208	4x61	4x65	Shared	4.07	8.82	No	Yes	No	No	4	5
209	4x61	E2x52	Shared	5.75	14.94	No	Yes	Yes	Yes	4	3
210	4x63	4x64	Shared	12.56	6.91	No	No	No	No	4	5
211	4x64	E2.F207	Shared	25.72	11.255	No	No	Yes	Yes	5	4
212	4x65	E2x52	Shared	15.24	8.795	No	No	Yes	Yes	5	3
213	E2.H193	E2.S191	Shared	6.97	0.695	No	No	No	No	3	4
214	E2.N206	E2.S191	Shared	5.96	9.685	No	No	No	No	4	4
215	E2.H193	E2x51	Shared	12.36	9.89	No	No	No	No	3	3
216	E2.A200	E2.H202	Shared	5.85	2.93	No	No	No	No	1	3
217	E2.F207	E2x52	Shared	9.28	10.835	Yes	Yes	Yes	Yes	4	3
218	5x32	E2.F207	Shared	2.89	2.165	No	No	Yes	Yes	4	4
219	5x35	E2.F207	Shared	3.01	3.765	No	No	Yes	Yes	4	4
220	5x40	6x55	Shared	2.62	3.92	Yes	Yes	No	No	3	5
221	5x40	6x58	Shared	8.34	5.36	Yes	Yes	No	Yes	3	5
222	5x40	6x59	Shared	8.77	6.265	Yes	Yes	Yes	No	3	5
223	5x44	6x56	Shared	5.54	2.765	No	No	No	No	4	5
224	5x461	5x50	Shared	4.06	2.03	No	No	Yes	No	5	9
225	5x47	5x51	Shared	3.65	4.26	Yes	Yes	No	No	8	7
226	5x47	6x49	Shared	2.59	5.84	Yes	Yes	Yes	Yes	8	5
227	5x47	6x52	Shared	12.44	15.84	Yes	Yes	No	No	8	8
228	5x54	5x58	Shared	3.59	4.19	No	No	No	Yes	8	8
229	5x56	5x60	Shared	11.98	14.7	No	No	No	No	4	4
230	5x58	6x41	Shared	6.31	5.05	No	Yes	No	No	8	8
231	6x44	6x48	Shared	13.03	6.015	Yes	Yes	Yes	Yes	9	9
232	6x44	7x45	Shared	9.05	6.79	Yes	Yes	No	Yes	9	9
233	6x47	7x45	Shared	8.85	9.585	No	No	No	Yes	9	9
234	6x48	6x51	Shared	5.79	5.305	Yes	Yes	Yes	Yes	9	6
235	6x48	7x41	Shared	8.44	9.145	Yes	Yes	No	No	9	8
236	6x49	6x50	Shared	3.5	6.12	Yes	Yes	No	No	5	9
237	6x51	6x55	Shared	6.31	7.57	Yes	Yes	No	No	6	5
238	6x51	7x37	Shared	8.74	7.49	Yes	Yes	No	No	6	7
239	6x54	7x33	Shared	3.39	3.39	No	No	No	No	4	5
240	6x54	7x37	Shared	3.17	3.965	No	No	No	No	4	7
241	6x56	6x60	Shared	2.77	2.77	No	No	No	No	5	4
242	6x58	6x62	Shared	6.65	3.325	No	Yes	No	No	5	2
243	6x61	E3.L286	Shared	2.83	3.535	Yes	No	No	No	3	1
244	6x61	7x26	Shared	2.48	4.34	Yes	No	No	No	3	3
245	7x27	E3.R288	Shared	6.98	13.375	No	Yes	No	No	1	4
246	7x38	Lig	Shared	8.51	3.33	No	No	Yes	Yes	5	0
247	7x42	Lig	Shared	28.23	7.845	Yes	Yes	Yes	Yes	6	0
248	7x54	8x50	Shared	2.77	8.32	No	No	Yes	Yes	7	8
249	7x56	8x47	Shared	3.68	0.92	Yes	No	No	No	7	8
250	8x49	8x53	Shared	4.95	2.475	No	No	Yes	Yes	6	5
251	8x51	8x54	Shared	2.48	1.24	No	No	Yes	No	8	6
252	8x54	8x55	Shared	9.31	6.4	Yes	No	No	No	6	2
253	3x29	Lig	Shared	2.42	3.705	No	No	Yes	Yes	6	0
254	1x46	7x47	Shared	1.96	3.92	No	No	No	No	8	8
255	I2.P164	I2.P165	Shared	1.95	1.95	Yes	No	No	No	6	2
256	5x35	5x38	Shared	1.95	1.95	No	No	No	No	4	3
257	1x36	2x65	Shared	1.87	1.87	No	No	No	No	4	5
258	3x44	5x50	Shared	1.87	2.805	No	No	Yes	No	7	9
259	1x46	2x54	Shared	1.84	4.6	No	No	No	No	8	6
260	5x34	5x35	Shared	1.84	0.92	No	No	No	No	1	4
261	1x37	1x40	Shared	1.71	0.855	No	No	No	No	5	6
262	1x48	1x49	Shared	1.71	3.42	No	No	No	No	5	7
263	4x51	4x54	Shared	1.71	1.71	No	No	No	No	4	4
264	5x53	5x57	Shared	1.71	1.71	No	No	No	No	7	7
265	6x63	6x64	Shared	1.71	0.855	No	No	No	No	1	1
266	1x53	2x47	Shared	1.7	3.39	No	No	No	No	9	9
267	3x44	5x53	Shared	1.7	3.39	No	No	No	No	7	7
268	6x45	6x49	Shared	1.68	0.84	No	No	Yes	Yes	5	5
269	1x35	1x36	Shared	1.64	1.64	No	Yes	No	No	5	4
270	4x59	4x60	Shared	1.64	2.46	No	No	No	No	4	7
271	5x49	5x50	Shared	1.64	4.105	No	No	Yes	No	6	9
272	5x41	5x45	Shared	1.6	1.6	No	No	No	No	4	5
273	1x54	2x44	Shared	1.58	0.79	No	No	Yes	Yes	7	6
274	6x43	7x52	Shared	1.58	1.58	No	No	No	No	6	8
275	2x44	2x48	Shared	1.49	1.49	Yes	Yes	No	No	6	6
276	6x36	7x56	Shared	1.49	7.45	No	No	Yes	No	8	7
277	6x39	7x52	Shared	1.49	0.745	No	No	No	No	5	8
278	2x56	3x31	Shared	1.47	4.42	No	No	No	No	7	5
279	5x37	6x63	Shared	1.47	1.47	No	No	No	No	1	1
280	6x49	6x53	Shared	1.47	3.685	Yes	Yes	No	No	5	6
281	3x34	4x54	Shared	1.43	3.565	No	No	No	No	6	4
282	1x47	2x55	Shared	1.38	3.46	No	No	No	No	6	5
283	7x48	7x51	Shared	1.38	1.385	No	No	No	No	6	6
284	E2.H194	E2.T201	Shared	1.37	6.165	No	No	No	No	2	5
285	E1x50	E2.A192	Shared	1.3	1.295	Yes	Yes	No	No	9	5
286	E2.H194	E2.N199	Shared	1.28	3.19	No	No	No	No	2	5
287	4x59	4x62	Shared	1.22	1.83	No	No	No	No	4	4
288	5x47	5x48	Shared	1.22	3.65	Yes	Yes	No	No	8	4
289	Lig	NT.S40	cxcr3_on	0	4.61	Yes	Yes	No	No	0	0
290	Lig	NT.P42	cxcr3_on	0	8.455	Yes	Yes	No	No	0	0
291	7x24	NT.C43	cxcr3_on	0	6.37	No	No	No	No	8	0
292	1x24	1x27	cxcr3_on	0	3.61	No	No	No	Yes	0	0
293	1x26	7x28	cxcr3_on	0	5.945	No	No	No	No	0	3
294	1x27	7x31	cxcr3_on	0	5.15	No	Yes	No	No	0	4
295	1x28	1x32	cxcr3_on	0	7.285	No	No	No	No	0	0
296	1x30	1x34	cxcr3_on	0	12.325	No	No	No	No	0	4
297	1x30	7x32	cxcr3_on	0	4.585	No	No	No	No	0	2
298	1x31	1x35	cxcr3_on	0	7.465	No	No	No	Yes	0	5
299	1x31	Lig	cxcr3_on	0	3.365	No	No	Yes	Yes	0	0
300	1x35	7x35	cxcr3_on	0	5.255	No	Yes	No	No	5	4
301	1x39	2x57	cxcr3_on	0	12.895	Yes	Yes	No	No	8	8
302	1x39	7x42	cxcr3_on	0	6.45	Yes	Yes	Yes	Yes	8	6
303	1x41	1x45	cxcr3_on	0	3.46	No	No	No	No	5	6
304	1x50	7x50	cxcr3_on	0	8.96	No	No	No	No	9	9
305	1x53	7x54	cxcr3_on	0	3.39	No	No	No	No	9	7
306	1x57	2x43	cxcr3_on	0	3.46	No	Yes	No	No	7	8
307	1x57	8x50	cxcr3_on	0	6.09	No	Yes	Yes	Yes	7	8
308	1x59	8x57	cxcr3_on	0	3.75	No	No	No	No	5	0
309	1x60	I1x49	cxcr3_on	0	4.53	Yes	Yes	No	No	5	6
310	8x53	I1x51	cxcr3_on	0	3.64	Yes	Yes	No	No	5	6
311	2x39	3x49	cxcr3_on	0	7.95	Yes	No	No	Yes	8	8
312	2x40	8x53	cxcr3_on	0	6.55	Yes	Yes	Yes	Yes	8	5
313	2x42	3x49	cxcr3_on	0	3.585	Yes	Yes	No	Yes	7	8
314	2x46	2x50	cxcr3_on	0	6.11	No	Yes	Yes	Yes	9	9
315	2x46	7x49	cxcr3_on	0	5.495	No	Yes	No	Yes	9	9
316	2x52	3x35	cxcr3_on	0	7.555	No	No	Yes	Yes	5	8
317	2x53	3x32	cxcr3_on	0	7.31	No	No	Yes	Yes	6	5
318	2x60	3x32	cxcr3_on	0	4.005	Yes	Yes	Yes	Yes	5	5
319	2x63	E2.H202	cxcr3_on	0	9.45	No	No	No	No	5	3
320	2x66	E1x49	cxcr3_on	0	5.015	No	No	No	No	4	3
321	E1x51	E1x52	cxcr3_on	0	3.93	No	No	Yes	Yes	3	7
322	3x29	4x61	cxcr3_on	0	3.355	No	No	No	Yes	6	4
323	3x31	3x35	cxcr3_on	0	4.12	No	No	Yes	Yes	5	8
324	3x32	Lig	cxcr3_on	0	19.185	Yes	Yes	Yes	Yes	5	0
325	3x33	E2x52	cxcr3_on	0	3.49	No	No	Yes	Yes	4	3
326	3x36	Lig	cxcr3_on	0	8.21	Yes	No	Yes	Yes	7	0
327	3x38	4x50	cxcr3_on	0	5.19	No	No	No	No	7	9
328	3x43	7x53	cxcr3_on	0	6.445	Yes	No	Yes	Yes	8	9
329	3x46	3x50	cxcr3_on	0	5.01	No	No	No	No	9	9
330	3x46	7x53	cxcr3_on	0	5.44	No	No	Yes	Yes	9	9
331	3x47	5x57	cxcr3_on	0	3.44	No	No	No	No	9	7
332	3x49	3x53	cxcr3_on	0	6.06	No	Yes	No	No	8	8
333	3x49	4x41	cxcr3_on	0	5.36	No	Yes	No	No	8	4
334	3x50	5x58	cxcr3_on	0	8.745	No	No	No	Yes	9	8
335	3x50	7x53	cxcr3_on	0	5.655	No	No	Yes	Yes	9	9
336	3x51	3x56	cxcr3_on	0	4.9	Yes	Yes	No	No	8	6
337	3x52	4x41	cxcr3_on	0	4.25	Yes	No	No	No	5	4
338	3x55	5x64	cxcr3_on	0	4.01	No	No	No	No	7	0
339	I2x52	I2x56	cxcr3_on	0	9.345	No	No	No	No	4	4
340	I2x53	I2x57	cxcr3_on	0	3.42	No	No	No	No	6	6
341	I2x55	I2x56	cxcr3_on	0	6.93	No	No	No	No	4	4
342	4x56	5x42	cxcr3_on	0	6.09	No	Yes	No	No	5	3
343	E2.E196	E2.H194	cxcr3_on	0	4.925	No	No	No	No	1	2
344	E2.D195	E2x51	cxcr3_on	0	7.18	No	No	No	No	2	3
345	E2.R197	Lig	cxcr3_on	0	23.085	No	No	Yes	Yes	4	0
346	5x39	E2x52	cxcr3_on	0	4.105	No	No	Yes	Yes	5	3
347	E2x52	Lig	cxcr3_on	0	7.14	Yes	Yes	Yes	Yes	3	0
348	5x33	6x62	cxcr3_on	0	3.92	No	No	No	No	2	2
349	5x36	Lig	cxcr3_on	0	16.095	No	No	Yes	Yes	4	0
350	5x40	7x34	cxcr3_on	0	3.715	Yes	Yes	No	No	3	5
351	5x40	Lig	cxcr3_on	0	5.88	Yes	Yes	Yes	Yes	3	0
352	5x43	Lig	cxcr3_on	0	12.065	No	No	Yes	Yes	5	0
353	5x44	6x52	cxcr3_on	0	4.5	No	No	No	No	4	8
354	5x51	6x44	cxcr3_on	0	3.65	No	No	Yes	Yes	7	9
355	5x54	6x44	cxcr3_on	0	4.355	No	No	Yes	Yes	8	9
356	5x58	6x37	cxcr3_on	0	9.46	No	Yes	No	No	8	7
357	5x62	6x34	cxcr3_on	0	3.535	No	No	No	Yes	5	0
358	5x62	6x37	cxcr3_on	0	4.47	No	No	No	No	5	7
359	5x65	6x34	cxcr3_on	0	4.24	No	No	No	Yes	0	0
360	5x66	6x34	cxcr3_on	0	3.535	No	No	No	Yes	0	0
361	6x30	6x31	cxcr3_on	0	5.465	No	No	No	No	0	0
362	6x31	6x35	cxcr3_on	0	5.465	No	No	No	No	0	5
363	6x40	7x53	cxcr3_on	0	5.05	No	No	Yes	Yes	8	9
364	6x48	7x45	cxcr3_on	0	6.88	Yes	Yes	No	Yes	9	9
365	6x50	7x37	cxcr3_on	0	4.375	No	No	No	No	9	7
366	6x51	6x52	cxcr3_on	0	5.445	Yes	Yes	No	No	6	8
367	6x51	Lig	cxcr3_on	0	11.76	Yes	Yes	Yes	Yes	6	0
368	6x58	7x30	cxcr3_on	0	3.65	No	Yes	No	No	5	4
369	6x58	7x34	cxcr3_on	0	7.605	No	Yes	No	No	5	5
370	6x62	6x63	cxcr3_on	0	3.395	No	No	No	No	2	1
371	7x26	E3.A287	cxcr3_on	0	6.22	No	No	No	No	3	1
372	7x25	7x29	cxcr3_on	0	3.75	No	No	No	No	2	3
373	7x27	Lig	cxcr3_on	0	6.395	No	Yes	Yes	Yes	1	0
374	7x38	7x42	cxcr3_on	0	7.635	No	No	Yes	Yes	5	6
375	7x45	7x49	cxcr3_on	0	8.295	No	Yes	No	Yes	9	9
376	7x49	7x50	cxcr3_on	0	4.89	No	Yes	No	No	9	9
377	7x52	7x53	cxcr3_on	0	3.515	No	No	Yes	Yes	8	9
378	7x55	8x50	cxcr3_on	0	5.895	No	No	Yes	Yes	7	8
379	8x52	8x55	cxcr3_on	0	3.27	No	No	No	No	5	2
380	8x60	8x61	cxcr3_on	0	5.465	No	No	No	No	0	0
381	Lig	Lig	cxcr3_on	0	179.955	Yes	Yes	Yes	Yes	0	0
382	1x24	7x27	cxcr3_on	0	4.46	No	No	No	Yes	0	1
383	1x31	7x31	cxcr3_on	0	3.325	No	No	No	No	0	4
384	E2.D195	E2.R197	cxcr3_on	0	3.575	No	No	No	No	2	4
385	5x33	5x36	cxcr3_on	0	9.345	No	No	No	No	2	4
386	1x42	7x47	cxcr3_on	0	3.17	No	No	No	No	7	8
387	1x35	2x64	cxcr3_on	0	3.15	No	Yes	No	No	5	5
388	6x30	6x34	cxcr3_on	0	3.1	No	No	No	Yes	0	0
389	5x58	5x61	cxcr3_on	0	3.025	No	Yes	No	No	8	8
390	E2.H202	Lig	cxcr3_on	0	3.025	No	No	Yes	Yes	3	0
391	1x27	1x28	cxcr3_on	0	3.005	No	Yes	No	No	0	0
392	1x47	2x54	cxcr3_on	0	2.98	No	No	No	No	6	6
393	3x34	3x35	cxcr3_on	0	2.83	No	No	Yes	Yes	6	8
394	1x60	I1x50	cxcr3_on	0	2.765	Yes	Yes	No	No	5	7
395	6x61	7x27	cxcr3_on	0	2.705	Yes	No	No	Yes	3	1
396	1x25	1x29	cxcr3_on	0	2.695	No	No	No	No	0	0
397	NT.P41	NT.S40	cxcr3_on	0	2.67	No	No	No	No	0	0
398	5x68	6x30	cxcr3_on	0	2.635	No	No	No	No	0	0
399	1x30	7x36	cxcr3_on	0	2.62	No	No	No	No	0	6
400	8x48	8x51	cxcr3_on	0	2.615	No	No	No	No	5	8
401	3x22	E2.A192	cxcr3_on	0	2.565	No	No	No	No	3	5
402	1x60	8x56	cxcr3_on	0	2.48	Yes	Yes	No	No	5	0
403	3x56	I2x52	cxcr3_on	0	2.475	No	No	No	No	6	4
404	I3.G247	I3.Q248	cxcr3_on	0	2.465	No	No	No	No	0	0
405	1x27	7x28	cxcr3_on	0	2.445	No	Yes	No	No	0	3
406	6x32	6x36	cxcr3_on	0	2.43	No	No	No	No	0	8
407	7x23	E3.A287	cxcr3_on	0	2.345	No	No	No	No	5	1
408	8x55	8x59	cxcr3_on	0	2.28	No	No	No	No	2	0
409	5x62	6x38	cxcr3_on	0	2.235	No	No	No	No	5	5
410	6x42	6x46	cxcr3_on	0	2.235	No	No	No	No	5	5
411	7x39	7x42	cxcr3_on	0	2.175	No	No	Yes	Yes	5	6
412	1x28	E2.L198	cxcr3_on	0	2.075	No	No	No	No	0	1
413	8x58	8x59	cxcr3_on	0	2.075	No	No	No	No	0	0
414	3x40	5x461	cxcr3_on	0	1.95	No	No	No	No	8	5
415	4x62	4x63	cxcr3_on	0	1.885	No	No	No	No	4	4
416	NT.C43	NT.P44	cxcr3_on	0	1.88	No	No	No	No	0	0
417	1x45	1x46	cxcr3_on	0	1.71	No	No	No	No	6	8
418	2x46	3x39	cxcr3_on	0	1.71	No	Yes	No	No	9	9
419	6x50	7x40	cxcr3_on	0	1.64	No	No	No	No	9	8
420	Lig	NT.C43	cxcr3_on	0	1.635	Yes	Yes	No	No	0	0
421	1x25	NT.P44	cxcr3_on	0	1.61	No	No	No	No	0	0
422	6x46	6x47	cxcr3_on	0	1.585	No	No	No	No	5	9
423	5x65	6x33	cxcr3_on	0	1.58	No	No	No	No	0	0
424	2x48	2x52	cxcr3_on	0	1.49	No	No	No	No	6	5
425	5x44	5x45	cxcr3_on	0	1.49	No	No	No	No	4	5
426	7x43	7x48	cxcr3_on	0	1.415	No	No	No	No	5	6
427	1x33	1x34	cxcr3_on	0	1.385	No	No	No	No	4	4
428	4x56	5x46	cxcr3_on	0	1.385	No	Yes	No	No	5	5
429	I2x51	I2x55	cxcr3_on	0	1.29	No	No	No	No	5	4
430	8x56	8x60	cxcr3_on	0	1.24	No	No	No	No	0	0
431	7x26	7x29	cxcr3_on	0	1.07	No	No	No	No	3	3
432	1x49	1x52	cxcr3_on	0	0.975	No	No	No	No	7	7
433	1x51	1x54	cxcr3_on	0	0.975	No	No	No	No	4	7
434	6x64	E3.A285	cxcr3_on	0	0.975	No	No	No	No	1	1
435	3x21	3x24	cxcr3_on	0	0.855	No	No	No	No	8	6
436	4x40	4x43	cxcr3_on	0	0.84	No	No	No	No	4	4
437	E2.A192	E2.T201	cxcr3_on	0	0.84	No	No	No	No	5	5
438	I3.G247	I3.R246	cxcr3_on	0	0.75	No	No	No	No	0	0
439	3x24	3x27	cxcr3_on	0	0.745	No	No	No	No	6	5
440	4x43	4x44	cxcr3_on	0	0.735	No	No	No	No	4	2
441	1x44	1x45	cxcr3_on	0	0.69	No	No	No	No	5	6
442	4x52	4x55	cxcr3_on	0	0.69	No	No	No	No	4	5
443	6x32	8x51	cxcr3_on	0	0.535	No	No	No	No	0	8

Orange: nodes, hubs and links specific of cxcr3_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of cxcr3_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	cxcr3_off Avg Int. Strength	cxcr3_on Avg Int. Strength	cxcr3_off Num Of Links	cxcr3_on Num Of Links	ConSurf
1	2x39	cxcr3_off	3.7875	7.95	4	1	8
2	3x36	cxcr3_off	8.306	6.27833	5	3	7
3	3x43	cxcr3_off	4.45	4.9525	4	2	8
4	3x52	cxcr3_off	4.662	4.16667	5	3	5
5	I2x54	cxcr3_off	5.055	0	6	0	5
6	I2.P164	cxcr3_off	2.33	3.005	4	2	6
7	4x42	cxcr3_off	4.596	4.345	5	2	8
8	5x50	cxcr3_off	2.8275	2.98	4	3	9
9	6x59	cxcr3_off	4.44	6.265	4	1	5
10	6x61	cxcr3_off	4.24	3.52667	5	3	3
11	7x56	cxcr3_off	2.6725	4.185	4	2	7
12	8x54	cxcr3_off	4.8725	4.06667	4	3	6
13	1x39	Shared	7.8375	7.19	4	6	8
14	1x60	Shared	5.9925	3.04	4	5	5
15	2x40	Shared	4.9975	6.05125	4	4	8
16	2x42	Shared	4.39125	4.3675	8	6	7
17	2x44	Shared	2.8425	1.955	4	4	6
18	2x50	Shared	6.04	6.03375	4	4	9
19	2x60	Shared	7.78667	9.7075	6	4	5
20	E1x50	Shared	7.36375	6.733	8	5	9
21	E1x52	Shared	9.8025	6.157	4	5	7
22	3x32	Shared	5.265	9.8175	4	4	5
23	3x35	Shared	6.8075	5.515	4	4	8
24	3x37	Shared	5.6925	4.3675	4	4	6
25	3x51	Shared	5.54571	7.1375	7	4	8
26	E2x52	Shared	9.3675	8.2175	4	6	3
27	E2.F207	Shared	10.104	7.005	5	4	4
28	5x40	Shared	7.315	5.028	4	5	3
29	5x47	Shared	4.468	7.3975	5	4	8
30	6x44	Shared	7.795	5.2025	4	4	9
31	6x48	Shared	7.78	6.872	6	5	9
32	6x49	Shared	2.31	4.12125	4	4	5
33	6x51	Shared	5.964	7.514	5	5	6
34	7x42	Shared	9.45	6.26	6	6	6
35	7x53	Shared	7.865	5.221	4	5	9
36	8x50	Shared	6.716	7.207	5	5	8
37	8x53	Shared	6.8125	3.69875	4	4	5
38	Lig	Shared	10.783	25.5948	10	21	0
39	1x27	cxcr3_on	0	3.5525	0	4	0
40	1x35	cxcr3_on	5.63333	5.378	3	5	5
41	1x57	cxcr3_on	3.5	3.75875	3	4	7
42	2x46	cxcr3_on	3.46	4.047	2	5	9
43	3x49	cxcr3_on	6.81	6.063	2	5	8
44	4x56	cxcr3_on	6.655	5.50125	2	4	5
45	4x61	cxcr3_on	6.41333	9.47125	3	4	4
46	5x58	cxcr3_on	6.69	6.77333	3	6	8
47	6x34	cxcr3_on	0	3.6025	0	4	0
48	6x58	cxcr3_on	6.38333	4.985	3	4	5
49	7x27	cxcr3_on	5.92	6.73375	3	4	1
50	7x45	cxcr3_on	8.95	7.8875	2	4	9
51	7x49	cxcr3_on	4.04	6.52125	1	4	9

Orange: nodes, hubs and links specific of cxcr3_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of cxcr3_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	cxcr3_off Recurrence	cxcr3_on Recurrence	cxcr3_off Hub1?	cxcr3_on Hub1?	cxcr3_off Hub2?	cxcr3_on Hub2?	ConSurf1	ConSurf2
1	1x35	1x36	cxcr3_off	11.3972	7.29417	No	Yes	No	No	5	4
2	7x42	Lig	cxcr3_off	16.1511	4.26457	Yes	Yes	Yes	Yes	6	0
3	2x57	7x42	cxcr3_off	10.9594	1.71138	No	No	Yes	Yes	8	6
4	7x38	Lig	cxcr3_off	33.0589	1.70675	No	No	Yes	Yes	5	0
5	3x32	7x38	cxcr3_off	14.8806	0	Yes	Yes	No	No	5	5
6	3x32	6x48	cxcr3_off	54.93	0	Yes	Yes	Yes	Yes	5	9
7	3x43	6x44	cxcr3_off	98.5343	0	Yes	No	Yes	Yes	8	9
8	3x43	6x40	cxcr3_off	24.812	0	Yes	No	No	No	8	8
9	6x40	7x52	cxcr3_off	23.7032	0	No	No	No	No	8	8
10	6x39	7x52	cxcr3_off	21.7474	3.17299	No	No	No	No	5	8
11	6x39	7x56	cxcr3_off	20.729	0	No	No	Yes	No	5	7
12	6x36	7x56	cxcr3_off	17.8452	3.15449	No	No	Yes	No	8	7
13	6x36	7x53	cxcr3_off	17.712	0	No	No	Yes	Yes	8	9
14	7x53	8x50	cxcr3_off	13.1912	0	Yes	Yes	Yes	Yes	9	8
15	1x53	8x50	cxcr3_off	10.1123	3.14061	No	No	Yes	Yes	9	8
16	3x32	7x42	cxcr3_off	43.8279	6.80388	Yes	Yes	Yes	Yes	5	6
17	6x51	7x38	cxcr3_off	19.7678	0	Yes	Yes	No	No	6	5
18	2x46	3x42	cxcr3_off	76.687	6.47549	No	Yes	No	No	9	8
19	2x42	3x42	cxcr3_off	75.4212	0	Yes	Yes	No	No	7	8
20	2x41	2x42	cxcr3_off	19.3014	0	No	No	Yes	Yes	6	7
21	1x60	2x40	cxcr3_off	18.2212	0	Yes	Yes	Yes	Yes	5	8
22	2x37	2x39	cxcr3_off	10.2408	0	No	No	Yes	No	7	8
23	2x42	I2x54	cxcr3_off	47.1019	0	Yes	Yes	Yes	No	7	5
24	2x45	4x46	cxcr3_off	15.9941	8.3765	No	No	No	No	9	7
25	2x45	4x50	cxcr3_off	14.6997	6.2951	No	No	No	No	9	9
26	2x60	E1x50	cxcr3_off	19.7392	0	Yes	Yes	Yes	Yes	5	9
27	3x33	3x36	cxcr3_off	24.7121	0	No	No	Yes	No	4	7
28	3x33	4x61	cxcr3_off	23.4606	0.00925069	No	No	No	Yes	4	4
29	4x61	4x65	cxcr3_off	10.6929	0.00925069	No	Yes	No	No	4	5
30	3x34	4x50	cxcr3_off	12.0872	0	No	No	No	No	6	9
31	3x36	6x52	cxcr3_off	14.9377	0	Yes	No	No	No	7	8
32	4x41	I2x54	cxcr3_off	58.2136	0	No	No	Yes	No	4	5
33	4x41	I2x53	cxcr3_off	50.157	0	No	No	No	No	4	6
34	3x52	I2x53	cxcr3_off	42.6525	8.3765	Yes	No	No	No	5	6
35	3x48	3x52	cxcr3_off	13.9145	2.10453	No	No	Yes	No	6	5
36	3x48	5x57	cxcr3_off	12.406	0	No	No	No	No	6	7
37	3x44	5x50	cxcr3_off	15.7466	8.56152	No	No	Yes	No	7	9
38	3x51	3x52	cxcr3_off	22.9181	0	Yes	Yes	Yes	No	8	5
39	4x61	E2x52	cxcr3_off	11.6779	1.89177	No	Yes	Yes	Yes	4	3
40	6x51	6x55	cxcr3_off	26.5299	6.48936	Yes	Yes	No	No	6	5
41	5x40	6x55	cxcr3_off	12.2966	5.98982	Yes	Yes	No	No	3	5
42	6x55	6x59	cxcr3_off	13.215	0	No	No	Yes	No	5	5
43	5x47	6x52	cxcr3_off	14.3571	7.76596	Yes	Yes	No	No	8	8
44	1x35	Lig	cxcr3_off	13.7289	0	No	Yes	Yes	Yes	5	0
45	2x60	7x42	cxcr3_off	18.778	0	Yes	Yes	Yes	Yes	5	6
46	8x50	8x53	cxcr3_off	11.9539	0	Yes	Yes	Yes	Yes	8	5
47	1x38	1x39	Shared	11.3972	39.9584	No	No	Yes	Yes	6	8
48	1x39	Lig	Shared	16.5461	46.679	Yes	Yes	Yes	Yes	8	0
49	6x44	6x48	Shared	100	95.8048	Yes	Yes	Yes	Yes	9	9
50	6x48	6x51	Shared	35.7999	70.7956	Yes	Yes	Yes	Yes	9	6
51	1x56	8x50	Shared	12.111	18.2701	No	No	Yes	Yes	7	8
52	1x56	8x54	Shared	10.5216	16.7946	No	No	Yes	No	7	6
53	2x46	3x43	Shared	77.1581	13.8159	No	Yes	Yes	No	9	8
54	2x41	I1x51	Shared	24.812	15.6429	No	No	No	No	6	6
55	2x40	I1x51	Shared	23.6176	11.9935	Yes	Yes	No	No	8	6
56	1x57	2x40	Shared	11.2163	23.9177	No	Yes	Yes	Yes	7	8
57	1x57	2x44	Shared	10.4645	36.7299	No	Yes	Yes	Yes	7	6
58	2x42	3x46	Shared	11.578	47.951	Yes	Yes	No	No	7	9
59	2x42	4x46	Shared	17.0934	10.4487	Yes	Yes	No	No	7	7
60	3x36	6x48	Shared	42.0957	65.0601	Yes	No	Yes	Yes	7	9
61	5x53	5x57	Shared	21.9806	12.7891	No	No	No	No	7	7
62	3x44	5x53	Shared	18.8684	10.6799	No	No	No	No	7	7
63	3x51	5x57	Shared	12.6725	21.1332	Yes	Yes	No	No	8	7
64	1x60	8x53	Shared	16.1416	12.0398	Yes	Yes	Yes	Yes	5	5
65	1x24	7x27	cxcr3_on	0	12.1045	No	No	No	Yes	0	1
66	7x27	Lig	cxcr3_on	0	27.197	No	Yes	Yes	Yes	1	0
67	1x24	1x27	cxcr3_on	0	10.37	No	No	No	Yes	0	0
68	1x27	7x31	cxcr3_on	0	10.9297	No	Yes	No	No	0	4
69	1x31	7x31	cxcr3_on	0	12.5393	No	No	No	No	0	4
70	1x31	Lig	cxcr3_on	0	21.2627	No	No	Yes	Yes	0	0
71	1x27	1x28	cxcr3_on	0	10.4302	No	Yes	No	No	0	0
72	1x34	1x38	cxcr3_on	2.86	10.333	No	No	No	No	4	6
73	1x35	1x39	cxcr3_on	0.138003	10.6753	No	Yes	Yes	Yes	5	8
74	1x38	1x42	cxcr3_on	5.71524	28.358	No	No	No	No	6	7
75	1x46	7x47	cxcr3_on	2.41268	18.4366	No	No	No	No	8	8
76	1x42	7x47	cxcr3_on	0	20.4394	No	No	No	No	7	8
77	1x46	2x54	cxcr3_on	3.60712	10.333	No	No	No	No	8	6
78	7x45	7x49	cxcr3_on	0	32.0352	No	Yes	No	Yes	9	9
79	6x48	7x45	cxcr3_on	0	35.8788	Yes	Yes	No	Yes	9	9
80	3x36	Lig	cxcr3_on	0	67.8538	Yes	No	Yes	Yes	7	0
81	6x51	Lig	cxcr3_on	0	80.0601	Yes	Yes	Yes	Yes	6	0
82	1x57	8x50	cxcr3_on	0	25.407	No	Yes	Yes	Yes	7	8
83	2x44	2x48	cxcr3_on	1.77501	39.9769	Yes	Yes	No	No	6	6
84	2x48	2x52	cxcr3_on	0	41.1008	No	No	No	No	6	5
85	2x52	3x35	cxcr3_on	0	42.308	No	No	Yes	Yes	5	8
86	2x53	3x35	cxcr3_on	1.83687	47.951	No	No	Yes	Yes	6	8
87	2x53	3x32	cxcr3_on	0	49.3895	No	No	Yes	Yes	6	5
88	3x32	Lig	cxcr3_on	0	43.6031	Yes	Yes	Yes	Yes	5	0
89	2x40	8x53	cxcr3_on	0	10.6198	Yes	Yes	Yes	Yes	8	5
90	2x42	3x49	cxcr3_on	0	22.4283	Yes	Yes	No	Yes	7	8
91	3x46	3x50	cxcr3_on	0	44.2784	No	No	No	No	9	9
92	3x50	5x58	cxcr3_on	0	54.9722	No	No	No	Yes	9	8
93	5x54	5x58	cxcr3_on	0	68.7234	No	No	No	Yes	8	8
94	5x54	6x44	cxcr3_on	0	100	No	No	Yes	Yes	8	9
95	2x41	4x42	cxcr3_on	6.74312	16.4662	No	No	Yes	No	6	8
96	2x42	4x42	cxcr3_on	2.93614	18.1129	Yes	Yes	Yes	No	7	8
97	2x46	7x49	cxcr3_on	0	18.3996	No	Yes	No	Yes	9	9
98	E1x50	E1x52	cxcr3_on	3.96402	16.3552	Yes	Yes	Yes	Yes	9	7
99	2x63	E1x50	cxcr3_on	0.071381	35.333	No	No	Yes	Yes	5	9
100	2x63	E2.H202	cxcr3_on	0	37.0028	No	No	No	No	5	3
101	E2.H202	Lig	cxcr3_on	0	40.111	No	No	Yes	Yes	3	0
102	E2x52	Lig	cxcr3_on	0	27.9833	Yes	Yes	Yes	Yes	3	0
103	4x64	E2.F207	cxcr3_on	2.81241	10.9852	No	No	Yes	Yes	5	4
104	E2.F207	E2x52	cxcr3_on	9.65547	19.889	Yes	Yes	Yes	Yes	4	3
105	3x36	3x37	cxcr3_on	5.57248	10.8696	Yes	No	Yes	Yes	7	6
106	3x37	4x56	cxcr3_on	3.00276	12.2988	Yes	Yes	No	Yes	6	5
107	3x43	7x53	cxcr3_on	0	12.6272	Yes	No	Yes	Yes	8	9
108	3x47	5x57	cxcr3_on	0	35.3793	No	No	No	No	9	7
109	3x47	5x54	cxcr3_on	1.38479	30.2174	No	No	No	No	9	8
110	3x52	4x41	cxcr3_on	0	12.5069	Yes	No	No	No	5	4
111	3x49	4x41	cxcr3_on	0	14.3154	No	Yes	No	No	8	4
112	3x51	3x56	cxcr3_on	0	10.6337	Yes	Yes	No	No	8	6
113	E2.R197	Lig	cxcr3_on	0	10.7724	No	No	Yes	Yes	4	0
114	E1x50	E2.A192	cxcr3_on	1.3372	14.5745	Yes	Yes	No	No	9	5
115	5x33	5x36	cxcr3_on	0	10.4949	No	No	No	No	2	4
116	5x36	Lig	cxcr3_on	0	12.0722	No	No	Yes	Yes	4	0
117	6x58	6x62	cxcr3_on	0.0380699	11.5634	No	Yes	No	No	5	2
118	5x40	6x58	cxcr3_on	7.26183	15.9158	Yes	Yes	No	Yes	3	5
119	5x40	Lig	cxcr3_on	0	18.1314	Yes	Yes	Yes	Yes	3	0
120	6x51	6x52	cxcr3_on	0	14.482	Yes	Yes	No	No	6	8
121	6x51	7x37	cxcr3_on	4.09251	10.2636	Yes	Yes	No	No	6	7
122	5x58	6x37	cxcr3_on	0	23.1961	No	Yes	No	No	8	7
123	5x62	6x37	cxcr3_on	0	21.1332	No	No	No	No	5	7
124	5x62	6x34	cxcr3_on	0	16.9796	No	No	No	Yes	5	0
125	6x61	7x27	cxcr3_on	0	12.4144	Yes	No	No	Yes	3	1
126	6x62	6x63	cxcr3_on	0	16.3599	No	No	No	No	2	1
127	7x52	7x53	cxcr3_on	0	10.3423	No	No	Yes	Yes	8	9

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
1x35	1x39	Shared	9.38	9.38	1	0	1	1
1x35	Lig	cxcr3_off	5.88	0	1	0	1	0
1x36	2x64	cxcr3_off	3.74	0	0	0	2	2
1x38	1x39	Shared	3.52	4.1	0	0	2	1
1x39	2x61	Shared	2.67	4	1	1	1	2
1x39	Lig	Shared	15.78	6.315	1	1	1	0
2x53	7x42	cxcr3_off	8.21	0	1	0	2	1
2x56	2x60	Shared	3.64	5.455	1	0	2	1
2x56	7x42	cxcr3_off	2.5	0	1	0	2	1
2x57	7x42	Shared	4.69	4.685	0	1	2	1
2x60	2x63	cxcr3_off	3.35	0	1	1	1	2
2x60	E1x50	cxcr3_off	8.43	0	1	1	1	2
2x60	3x28	Shared	3.89	3.89	1	1	1	2
2x60	7x42	cxcr3_off	4.82	0	1	1	1	1
2x60	Lig	Shared	22.59	25.48	1	1	1	0
2x63	E1x50	Shared	10.05	10.05	1	0	2	2
3x32	6x48	cxcr3_off	5.01	0	1	1	1	2
3x32	6x51	cxcr3_off	5.16	0	1	1	1	1
3x32	7x38	cxcr3_off	2.64	0	1	1	1	1
3x32	7x42	Shared	8.25	8.77	1	1	1	1
3x33	3x36	cxcr3_off	6.04	0	0	1	2	1
3x33	4x61	Shared	9.42	10.77	0	1	2	2
3x36	3x37	Shared	7.22	3.61	1	1	1	2
3x36	5x43	cxcr3_off	8.2	0	1	1	1	1
3x36	6x48	Shared	11.02	7.015	1	1	1	2
3x36	6x52	cxcr3_off	9.05	0	1	1	1	2
3x37	5x43	Shared	5.64	3.945	1	0	2	1
4x61	4x65	Shared	4.07	8.82	5	1	2	2
4x61	E2x52	Shared	5.75	14.94	5	1	2	1
4x65	E2x52	Shared	15.24	8.795	5	1	2	1
E2.D195	E2.L198	cxcr3_off	8.14	0	0	0	2	2
E2.A200	E2.H202	Shared	5.85	2.93	0	0	2	1
E2.F207	E2x52	Shared	9.28	10.835	5	0	2	1
5x36	E2x52	cxcr3_off	7.2	0	5	1	1	1
5x36	E2.F207	cxcr3_off	9.62	0	5	1	1	2
5x40	6x55	Shared	2.62	3.92	1	1	1	2
5x40	6x58	Shared	8.34	5.36	1	1	1	2
5x40	6x59	Shared	8.77	6.265	1	1	1	2
5x40	6x62	cxcr3_off	9.53	0	1	1	1	2
5x43	6x52	cxcr3_off	3.71	0	1	1	1	2
6x48	6x51	Shared	5.79	5.305	1	1	2	1
6x51	6x55	Shared	6.31	7.57	1	1	1	2
6x51	7x37	Shared	8.74	7.49	1	1	1	2
6x51	7x38	cxcr3_off	3.82	0	1	1	1	1
6x54	7x34	cxcr3_off	4.55	0	0	0	2	1
6x54	7x37	Shared	3.17	3.965	0	0	2	2
6x55	6x59	cxcr3_off	3.07	0	1	0	2	2
6x58	6x61	cxcr3_off	4.16	0	1	1	2	2
6x58	6x62	Shared	6.65	3.325	1	1	2	2
6x61	E3.R288	cxcr3_off	8.69	0	1	0	2	2
6x61	7x30	cxcr3_off	3.04	0	1	0	2	2
6x62	E3.R288	cxcr3_off	7.15	0	1	0	2	2
7x27	E3.R288	Shared	6.98	13.375	0	1	1	2
7x27	7x30	cxcr3_off	4.28	0	0	1	1	2
7x27	7x31	cxcr3_off	6.5	0	0	1	1	2
7x34	Lig	cxcr3_off	4.99	0	0	1	1	0
7x35	Lig	cxcr3_off	15.95	0	0	0	1	0
7x38	Lig	Shared	8.51	3.33	1	1	1	0
7x42	Lig	Shared	28.23	7.845	1	1	1	0
3x29	Lig	Shared	2.42	3.705	0	1	1	0
7x39	Lig	cxcr3_off	2.42	0	0	0	1	0
1x35	1x36	Shared	1.64	1.64	1	0	1	2
7x32	7x36	cxcr3_off	1.6	0	0	0	1	2
E2.L198	E2.R197	cxcr3_off	1.21	0	0	0	2	1
E2.E196	E2.R197	cxcr3_off	1.16	0	0	0	2	1
7x32	Lig	cxcr3_off	1.06	0	0	0	1	0
Lig	NT.S40	cxcr3_on	0	4.61	1	1	0	1
Lig	NT.P42	cxcr3_on	0	8.455	1	1	0	1
7x24	NT.C43	cxcr3_on	0	6.37	0	0	2	1
1x30	7x32	cxcr3_on	0	4.585	0	0	2	1
1x31	1x35	cxcr3_on	0	7.465	0	1	1	1
1x31	Lig	cxcr3_on	0	3.365	0	1	1	0
1x35	7x35	cxcr3_on	0	5.255	1	0	1	1
1x39	2x57	cxcr3_on	0	12.895	1	1	1	2
1x39	7x42	cxcr3_on	0	6.45	1	1	1	1
2x53	3x32	cxcr3_on	0	7.31	1	0	2	1
2x60	3x32	cxcr3_on	0	4.005	1	1	1	1
2x63	E2.H202	cxcr3_on	0	9.45	1	0	2	1
3x29	4x61	cxcr3_on	0	3.355	0	1	1	2
3x32	Lig	cxcr3_on	0	19.185	1	1	1	0
3x33	E2x52	cxcr3_on	0	3.49	0	1	2	1
3x36	Lig	cxcr3_on	0	8.21	1	1	1	0
E2.R197	Lig	cxcr3_on	0	23.085	0	1	1	0
5x39	E2x52	cxcr3_on	0	4.105	0	0	2	1
E2x52	Lig	cxcr3_on	0	7.14	5	1	1	0
5x33	6x62	cxcr3_on	0	3.92	0	0	2	2
5x36	Lig	cxcr3_on	0	16.095	5	1	1	0
5x40	7x34	cxcr3_on	0	3.715	1	1	1	1
5x40	Lig	cxcr3_on	0	5.88	1	1	1	0
5x43	Lig	cxcr3_on	0	12.065	1	1	1	0
6x51	6x52	cxcr3_on	0	5.445	1	1	1	2
6x51	Lig	cxcr3_on	0	11.76	1	1	1	0
6x58	7x30	cxcr3_on	0	3.65	1	1	2	2
6x58	7x34	cxcr3_on	0	7.605	1	1	2	1
7x27	Lig	cxcr3_on	0	6.395	0	1	1	0
7x38	7x42	cxcr3_on	0	7.635	1	1	1	1
1x24	7x27	cxcr3_on	0	4.46	0	0	2	1
1x31	7x31	cxcr3_on	0	3.325	0	1	1	2
E2.D195	E2.R197	cxcr3_on	0	3.575	0	0	2	1
5x33	5x36	cxcr3_on	0	9.345	0	0	2	1
1x35	2x64	cxcr3_on	0	3.15	1	0	1	2
E2.H202	Lig	cxcr3_on	0	3.025	0	1	1	0
6x61	7x27	cxcr3_on	0	2.705	1	0	2	1
NT.P41	NT.S40	cxcr3_on	0	2.67	0	0	2	1
1x30	7x36	cxcr3_on	0	2.62	0	0	2	2
7x39	7x42	cxcr3_on	0	2.175	0	0	1	1
NT.C43	NT.P44	cxcr3_on	0	1.88	0	1	1	2
Lig	NT.C43	cxcr3_on	0	1.635	1	1	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	cxcr3_off	8K2W-CXCR3-AMG487
	cxcr3_on	8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2

Network Difference
Value	cxcr3_off	cxcr3_on
I_min	2.44	3.24
Number of Linked Nodes	246	286
Number of Specific Nodes	4 (1.63%)	44 (15.38%)
Number of Shared Nodes	242 (98.37%)	242 (84.62%)
Number of Links	288	311
Number of Specific Links	132 (45.83%)	155 (49.84%)
Number of Shared Links	156 (54.17%)	156 (50.16%)
Number of Hubs	38	39
Number of Specific Hubs	12 (31.58%)	13 (33.33%)
Number of Shared Hubs	26 (68.42%)	26 (66.67%)
Average % Shared Neighbours (Jaccard)	37.96
Average % Shared Neighbours (Otsuka)	46.69
Average % Shared Neighbours (Overlap Coefficient)	55.52
Average % Shared Cliques (k3-6)	51.60
Graphlets Similarity	0.624948

Paths Difference
Value	cxcr3_off	cxcr3_on
Number Of Nodes in MetaPath	62	79
Specific Nodes in MetaPath	26 (41.94%)	43 (54.43%)
Shared Nodes in MetaPath	242 (98.37%)	242 (98.37%)
Number Of Links MetaPath	64	81
Specific Links in MetaPath	46 (71.88%)	63 (77.78%)
Shared Links in MetaPath	156 (54.17%)	156 (54.17%)
Number of Shortest Paths	41103	62104
Length Of Smallest Path	3	3
Average Path Length	12.5608	11.3677
Length of Longest Path	26	25
Minimum Path Strength	1.185	0.7875
Average Path Strength	5.59717	5.94643
Maximum Path Strength	22.09	18.0067
Minimum Path Correlation	0.7	0.7
Average Path Correlation	0.907117	0.935048
Maximum Path Correlation	0.99	0.99
Minimum % Of Corr. Nodes	4.7619	5.88235
Average % Of Corr. Nodes	42.2508	54.8447
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	47.5755	45.8358
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

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