Orange: nodes, hubs and links specific of cxcr3_on_gp network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of cxcr3_off network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.


Index Hub Owner cxcr3_on_gp Avg Int. Strength cxcr3_off Avg Int. Strength cxcr3_on_gp Num Of Links cxcr3_off Num Of Links ConSurf
1G.S1.02 cxcr3_on_gp5.8050405
2G.S1.07 cxcr3_on_gp3.768750409
3G.S2.08 cxcr3_on_gp8.0850405
4G.S3.01 cxcr3_on_gp5.050404
5G.S3.03 cxcr3_on_gp7.8790507
6G.S3.04 cxcr3_on_gp7.8710506
7G.S3.06 cxcr3_on_gp7.3550505
8G.s3h2.03 cxcr3_on_gp4.80509
9G.H2.02 cxcr3_on_gp4.55250408
10G.H2.03 cxcr3_on_gp4.621250409
11G.H2.04 cxcr3_on_gp4.3570509
12G.H2.06 cxcr3_on_gp5.163130809
13G.H2.07 cxcr3_on_gp4.543120809
14G.H2.08 cxcr3_on_gp3.6540508
15G.H2.09 cxcr3_on_gp5.540408
16G.H2.10 cxcr3_on_gp3.811670607
17G.h2s4.01 cxcr3_on_gp5.413330609
18G.H3.06 cxcr3_on_gp4.81750406
19G.H3.09 cxcr3_on_gp5.8070509
20G.H3.13 cxcr3_on_gp4.43250405
21G.H3.15 cxcr3_on_gp4.523750408
22G.H3.17 cxcr3_on_gp6.869290705
23G.H3.18 cxcr3_on_gp5.4450409
24G.S5.03 cxcr3_on_gp2.8950408
25G.S5.04 cxcr3_on_gp3.4030509
26G.S5.05 cxcr3_on_gp4.4150509
27G.S5.06 cxcr3_on_gp5.381250408
28G.S5.07 cxcr3_on_gp4.7720509
29G.hgh4.02 cxcr3_on_gp6.241870807
30G.hgh4.05 cxcr3_on_gp6.0650607
31G.H4.03 cxcr3_on_gp9.5550404
32G.H4.10 cxcr3_on_gp5.4510506
33G.H4.15 cxcr3_on_gp5.1740508
34G.h4s6.02 cxcr3_on_gp5.56750408
35G.S6.02 cxcr3_on_gp9.240407
36G.s6h5.01 cxcr3_on_gp6.26750409
37G.H5.08 cxcr3_on_gp4.8310508
38G.H5.15 cxcr3_on_gp3.541250407
39G.H5.17 cxcr3_on_gp4.660405
40G.H5.26 cxcr3_on_gp7.836250405
41b.1x4 cxcr3_on_gp3.366250408
42b.1x11 cxcr3_on_gp4.3450508
43b.1x16 cxcr3_on_gp3.913750404
44b.h2x1 cxcr3_on_gp4.373750405
45b.lhb1x6 cxcr3_on_gp5.158750403
46b.b1x6 cxcr3_on_gp7.350409
47b.l1x3 cxcr3_on_gp8.459170609
48b.b2x1 cxcr3_on_gp8.141670608
49b.b2x5 cxcr3_on_gp5.570830607
50b.l3x2 cxcr3_on_gp5.0410509
51b.b4x2 cxcr3_on_gp4.6650408
52b.b4x5 cxcr3_on_gp4.481250407
53b.b4x6 cxcr3_on_gp10.47170609
54b.b5x2 cxcr3_on_gp5.548750407
55b.b5x3 cxcr3_on_gp6.740710709
56b.b5x5 cxcr3_on_gp5.280405
57b.b5x7 cxcr3_on_gp4.650407
58b.l5x1 cxcr3_on_gp4.0110508
59b.l5x5 cxcr3_on_gp7.730609
60b.b6x1 cxcr3_on_gp3.560409
61b.b6x5 cxcr3_on_gp4.180506
62b.l6x5 cxcr3_on_gp6.468750404
63b.b7x1 cxcr3_on_gp5.8530504
64b.l7x2 cxcr3_on_gp3.926250409
65b.l7x4 cxcr3_on_gp4.283750409
66b.b8x4 cxcr3_on_gp5.304170606
67b.l9x3 cxcr3_on_gp6.532860709
68b.l9x6 cxcr3_on_gp5.288890908
69b.b10x5 cxcr3_on_gp4.443330609
70b.l10x1 cxcr3_on_gp4.68250403
71b.b11x4 cxcr3_on_gp5.3770509
72b.l11x2 cxcr3_on_gp8.4550409
73b.b12x5 cxcr3_on_gp3.418750406
74b.b12x6 cxcr3_on_gp8.9050608
75b.b13x3 cxcr3_on_gp7.34250404
76b.b13x7 cxcr3_on_gp8.060507
77b.l13x3 cxcr3_on_gp7.301430709
78b.l13x6 cxcr3_on_gp6.863750409
79b.l13x7 cxcr3_on_gp5.08750409
80b.b15x2 cxcr3_on_gp5.8850406
81b.b15x3 cxcr3_on_gp5.26250409
82b.l15x1 cxcr3_on_gp5.4120507
83b.l15x2 cxcr3_on_gp6.19250409
84b.b16x4 cxcr3_on_gp11.19750406
85b.b16x5 cxcr3_on_gp4.1710505
86b.b16x6 cxcr3_on_gp8.528330608
87b.b16x7 cxcr3_on_gp5.140409
88b.b17x2 cxcr3_on_gp3.32750403
89b.b17x4 cxcr3_on_gp4.4550505
90b.b17x5 cxcr3_on_gp8.3350407
91b.b17x7 cxcr3_on_gp7.083750408
92b.l17x3 cxcr3_on_gp8.002140709
93b.l17x6 cxcr3_on_gp6.50509
94b.b18x3 cxcr3_on_gp4.90408
95b.l18x1 cxcr3_on_gp6.00750606
96b.l18x2 cxcr3_on_gp5.30750407
97b.b19x2 cxcr3_on_gp6.5010506
98b.b19x4 cxcr3_on_gp5.70750408
99b.l19x1 cxcr3_on_gp5.651250409
100b.l19x2 cxcr3_on_gp7.4650409
101b.b20x2 cxcr3_on_gp5.9690506
102b.b20x4 cxcr3_on_gp9.3380508
103b.b20x6 cxcr3_on_gp7.6770506
104b.b21x1 cxcr3_on_gp8.3930507
105b.b21x7 cxcr3_on_gp6.010505
106b.l21x5 cxcr3_on_gp3.5250504
107b.b22x5 cxcr3_on_gp4.215830607
108b.l22x5 cxcr3_on_gp7.8510509
109b.b23x3 cxcr3_on_gp3.4160507
110b.b23x6 cxcr3_on_gp6.541430707
111b.l23x1 cxcr3_on_gp8.326250406
112b.b24x2 cxcr3_on_gp4.211250405
113b.b24x4 cxcr3_on_gp6.323330606
114b.b24x6 cxcr3_on_gp6.2350408
115b.b24x7 cxcr3_on_gp9.560409
116b.b25x3 cxcr3_on_gp7.05250405
117b.l25x3 cxcr3_on_gp8.051670609
118b.b26x3 cxcr3_on_gp3.5670506
119b.l27x1 cxcr3_on_gp10.07360709
120b.l27x2 cxcr3_on_gp7.51750409
121b.b28x3 cxcr3_on_gp4.3810507
122b.b28x4 cxcr3_on_gp8.58750406
123b.b28x6 cxcr3_on_gp9.29750409
124g.l1x2 cxcr3_on_gp2.538750402
125g.l1x4 cxcr3_on_gp5.521250408
126g.h2x11 cxcr3_on_gp9.768750406
127g.ctx3 cxcr3_on_gp6.00750609
128g.ctx5 cxcr3_on_gp4.146250409
129g.ctx6 cxcr3_on_gp4.3060506
130g.ctx15 cxcr3_on_gp7.88250409
131g.ctx16 cxcr3_on_gp5.89750608
1321x27 cxcr3_on_gp3.55250404
1331x35 cxcr3_on_gp5.3785.63333535
1341x57 cxcr3_on_gp3.758753.5437
1352x45 cxcr3_on_gp6.842510.545429
1362x46 cxcr3_on_gp4.0473.46529
1373x49 cxcr3_on_gp6.0636.81528
1383x50 cxcr3_on_gp5.5554.65639
1393x53 cxcr3_on_gp4.011253.73428
1403x56 cxcr3_on_gp3.6853.58333436
1414x56 cxcr3_on_gp5.501256.655425
1424x61 cxcr3_on_gp9.471256.41333434
1435x57 cxcr3_on_gp3.83254.63667437
1445x58 cxcr3_on_gp6.773336.69638
1456x34 cxcr3_on_gp3.60250406
1466x52 cxcr3_on_gp7.248.4438
1476x58 cxcr3_on_gp4.9856.38333435
1487x27 cxcr3_on_gp6.733755.92431
1497x34 cxcr3_on_gp4.3354.77425
1507x45 cxcr3_on_gp7.88758.95429
1517x49 cxcr3_on_gp6.521254.04419
1527x52 cxcr3_on_gp2.2051.52438
1531x39 Shared7.197.8375648
1541x60 Shared3.045.9925545
1552x40 Shared6.051254.9975448
1562x42 Shared4.36754.39125687
1572x44 Shared1.9552.8425446
1582x50 Shared6.033756.04449
1592x60 Shared8.3287.78667565
160E1x50 Shared6.085837.36375689
161E1x52 Shared6.1579.8025547
1623x32 Shared9.81755.265445
1633x35 Shared5.5156.8075448
1643x37 Shared4.085.6925546
1653x51 Shared6.2965.54571578
1663x52 Shared3.7294.662555
167E2x52 Shared8.21759.3675643
168E2.F207 Shared6.24610.104554
1695x40 Shared5.0287.315543
1705x47 Shared7.39754.468458
1716x44 Shared4.7717.795549
1726x48 Shared6.255837.78669
1736x49 Shared4.121252.31445
1746x51 Shared6.759175.964656
1757x42 Shared6.269.45666
1767x53 Shared5.2217.865549
1778x50 Shared7.2076.716558
1788x53 Shared3.698756.8125445
179Lig Shared21.972610.78325100
1802x39 cxcr3_off5.59253.7875248
1813x36 cxcr3_off6.278338.306357
1823x43 cxcr3_off4.316674.45348
183I2x54 cxcr3_off6.6455.055165
184I2.P164 cxcr3_off3.0052.33246
1854x42 cxcr3_off3.973334.596358
1865x50 cxcr3_off2.982.8275349
1876x59 cxcr3_off4.66754.44245
1886x61 cxcr3_off3.526674.24353
1897x56 cxcr3_off7.452.6725147
1908x54 cxcr3_off5.484.8725246
   
Orange: nodes, hubs and links specific of cxcr3_on_gp network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of cxcr3_off network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Owner cxcr3_on_gp Recurrence cxcr3_off Recurrence cxcr3_on_gp Hub1? cxcr3_off Hub1? cxcr3_on_gp Hub2? cxcr3_off Hub2? ConSurf1 ConSurf2
1b.b28x3 b.b2x3 cxcr3_on_gp14.57550YesNoNoNo76
2b.b26x2 b.b2x3 cxcr3_on_gp24.21870NoNoNoNo76
3b.b26x1 b.b26x2 cxcr3_on_gp24.55980NoNoNoNo97
4b.b26x1 b.l27x1 cxcr3_on_gp24.90270NoNoYesNo99
5G.S1.05 G.h2s4.01 cxcr3_on_gp20.39850NoNoYesNo99
6G.S1.05 G.S1.07 cxcr3_on_gp20.38170NoNoYesNo99
7G.S1.07 G.s1h1.01 cxcr3_on_gp1000YesNoNoNo99
8G.H1.01 G.s1h1.01 cxcr3_on_gp99.94170NoNoNoNo99
9G.H1.01 G.S1.06 cxcr3_on_gp99.70750NoNoNoNo98
10G.S1.06 G.S3.05 cxcr3_on_gp84.00410NoNoNoNo87
11G.S2.04 G.S3.05 cxcr3_on_gp83.93240NoNoNoNo67
12G.H1.08 G.S2.04 cxcr3_on_gp83.79670NoNoNoNo86
13G.H1.08 G.S2.06 cxcr3_on_gp83.66820NoNoNoNo89
14G.S2.06 G.S3.03 cxcr3_on_gp83.60420NoNoYesNo97
15G.H5.11 G.S3.03 cxcr3_on_gp82.61730NoNoYesNo87
16G.H5.11 G.H5.15 cxcr3_on_gp82.72280NoNoYesNo87
17G.H5.15 G.H5.19 cxcr3_on_gp82.46960YesNoNoNo78
183x53 G.H5.19 cxcr3_on_gp82.40650YesNoNoNo88
19G.H3.17 b.l27x1 cxcr3_on_gp17.99910YesNoYesNo59
20G.H2.08 G.H3.17 cxcr3_on_gp39.2560YesNoYesNo85
21G.H2.04 G.H2.08 cxcr3_on_gp14.64190YesNoYesNo98
22G.H2.04 G.H3.12 cxcr3_on_gp34.23160YesNoNoNo98
23G.H3.12 G.S1.07 cxcr3_on_gp56.93690NoNoYesNo89
24G.H2.08 G.H3.18 cxcr3_on_gp22.76740YesNoYesNo89
25G.H3.12 G.H3.18 cxcr3_on_gp22.79640NoNoYesNo89
26G.H3.15 G.H3.17 cxcr3_on_gp22.6150YesNoYesNo85
27G.H3.15 G.H3.18 cxcr3_on_gp22.78340YesNoYesNo89
28G.H3.18 G.S4.02 cxcr3_on_gp22.85590YesNoNoNo98
29G.S1.07 G.S4.02 cxcr3_on_gp22.8550YesNoNoNo98
30G.S1.06 G.S4.03 cxcr3_on_gp16.06860NoNoNoNo87
31G.S4.03 G.S5.03 cxcr3_on_gp15.83940NoNoYesNo78
32G.H2.04 G.H3.08 cxcr3_on_gp19.38990YesNoNoNo99
33G.H3.08 G.S4.04 cxcr3_on_gp19.32970NoNoNoNo99
34G.S4.04 G.S5.04 cxcr3_on_gp10.80230NoNoYesNo99
35G.H5.10 G.S6.02 cxcr3_on_gp14.30110NoNoYesNo67
36G.H5.10 G.S5.03 cxcr3_on_gp14.36770NoNoYesNo68
373x50 5x58 cxcr3_on_gp38.25060YesNoYesNo98
383x50 G.H5.23 cxcr3_on_gp76.67160YesNoNoNo94
393x53 G.H5.23 cxcr3_on_gp76.74550YesNoNoNo84
406x29 G.H5.17 cxcr3_on_gp13.22590NoNoYesNo45
416x29 G.H5.21 cxcr3_on_gp11.51390NoNoNoNo45
428x49 G.H5.21 cxcr3_on_gp11.32580NoNoNoNo65
43b.b10x1 b.l9x6 cxcr3_on_gp19.85210NoNoYesNo98
44b.b10x1 b.b11x5 cxcr3_on_gp19.73170NoNoNoNo96
45b.b11x5 b.l13x7 cxcr3_on_gp18.72480NoNoYesNo69
46b.l13x3 b.l13x7 cxcr3_on_gp14.91070YesNoYesNo99
47b.b16x4 b.l13x3 cxcr3_on_gp12.97260YesNoYesNo69
48b.b16x4 b.b17x6 cxcr3_on_gp12.69970YesNoNoNo67
49b.b17x6 g.h1x14 cxcr3_on_gp12.57040NoNoNoNo79
50b.1x15 g.h1x14 cxcr3_on_gp12.56660NoNoNoNo79
51b.l23x1 b.l25x6 cxcr3_on_gp45.87480YesNoNoNo68
52b.l21x7 b.l23x1 cxcr3_on_gp30.49190NoNoYesNo56
53b.b23x6 b.l21x7 cxcr3_on_gp28.86250YesNoNoNo75
54b.b23x6 b.b24x6 cxcr3_on_gp24.82910YesNoYesNo78
55b.b21x7 b.b24x6 cxcr3_on_gp24.35390YesNoYesNo58
56b.b22x1 b.l23x1 cxcr3_on_gp14.98180NoNoYesNo86
57b.b22x1 b.b22x2 cxcr3_on_gp14.70970NoNoNoNo88
585x54 5x58 cxcr3_on_gp36.31850NoNoYesNo88
595x54 6x44 cxcr3_on_gp36.92420NoNoYesYes89
603x36 Lig cxcr3_on_gp31.43370NoYesYesYes70
613x50 7x53 cxcr3_on_gp37.30670YesNoYesYes99
623x43 7x53 cxcr3_on_gp37.00840NoYesYesYes89
636x51 Lig cxcr3_on_gp31.56550YesYesYesYes60
648x49 8x53 cxcr3_on_gp10.94971.77025NoNoYesYes65
65E2.H202 Lig cxcr3_on_gp10.29350NoNoYesYes30
66G.H2.07 b.l9x6 cxcr3_on_gp25.47060YesNoYesNo98
67G.H2.04 G.H2.07 cxcr3_on_gp14.71180YesNoYesNo99
68b.b22x2 b.b26x3 cxcr3_on_gp14.43960NoNoYesNo86
69G.H2.07 G.h2s4.01 cxcr3_on_gp11.64540YesNoYesNo99
70G.H3.17 b.l25x6 cxcr3_on_gp43.49490YesNoNoNo58
716x44 6x48 Shared70.4547100YesYesYesYes99
723x36 6x48 Shared33.383942.0957NoYesYesYes79
733x43 6x44 Shared36.404598.5343NoYesYesYes89
746x48 6x51 Shared35.801735.7999YesYesYesYes96
751x39 Lig Shared12.057116.5461YesYesYesYes80
761x38 1x39 cxcr3_off9.0576811.3972NoNoYesYes68
771x35 1x36 cxcr3_off2.6913711.3972YesNoNoNo54
787x42 Lig cxcr3_off1.3232616.1511YesYesYesYes60
792x57 7x42 cxcr3_off0.44673810.9594NoNoYesYes86
807x38 Lig cxcr3_off0.4473933.0589NoNoYesYes50
813x32 7x38 cxcr3_off014.8806YesYesNoNo55
823x32 6x48 cxcr3_off054.93YesYesYesYes59
833x43 6x40 cxcr3_off024.812NoYesNoNo88
846x40 7x52 cxcr3_off9.31578e-0523.7032NoNoYesNo88
856x39 7x52 cxcr3_off0.13256321.7474NoNoYesNo58
866x39 7x56 cxcr3_off020.729NoNoNoYes57
876x36 7x56 cxcr3_off0.23377917.8452NoNoNoYes87
886x36 7x53 cxcr3_off017.712NoNoYesYes89
897x53 8x50 cxcr3_off013.1912YesYesYesYes98
901x53 8x50 cxcr3_off0.46695310.1123NoNoYesYes98
913x32 7x42 cxcr3_off0.1501743.8279YesYesYesYes56
926x51 7x38 cxcr3_off019.7678YesYesNoNo65
931x56 8x50 cxcr3_off1.4001112.111NoNoYesYes78
941x56 8x54 cxcr3_off1.1669910.5216NoNoNoYes76
952x46 3x43 cxcr3_off1.2226577.1581YesNoNoYes98
962x46 3x42 cxcr3_off0.63682676.687YesNoNoNo98
972x42 3x42 cxcr3_off075.4212YesYesNoNo78
982x41 2x42 cxcr3_off019.3014NoNoYesYes67
992x41 I1x51 cxcr3_off2.5284424.812NoNoNoNo66
1002x40 I1x51 cxcr3_off0.25874623.6176YesYesNoNo86
1011x57 2x40 cxcr3_off7.0149611.2163YesNoYesYes78
1021x60 2x40 cxcr3_off018.2212YesYesYesYes58
1031x57 2x44 cxcr3_off4.2773810.4645YesNoYesYes76
1042x42 3x46 cxcr3_off0.41781211.578YesYesNoNo79
1052x37 2x39 cxcr3_off010.2408NoNoNoYes78
1062x42 I2x54 cxcr3_off047.1019YesYesNoYes75
1072x42 4x46 cxcr3_off0.88369417.0934YesYesNoNo77
1082x45 4x46 cxcr3_off0.79538115.9941YesNoNoNo97
1092x45 4x50 cxcr3_off1.0626514.6997YesNoNoNo99
1102x60 E1x50 cxcr3_off019.7392YesYesYesYes59
1113x33 3x36 cxcr3_off024.7121NoNoNoYes47
1123x33 4x61 cxcr3_off0.44729723.4606NoNoYesNo44
1134x61 4x65 cxcr3_off0.00027947310.6929YesNoNoNo45
1143x34 4x50 cxcr3_off012.0872NoNoNoNo69
1153x36 6x52 cxcr3_off014.9377NoYesYesNo78
1164x41 I2x54 cxcr3_off058.2136NoNoNoYes45
1174x41 I2x53 cxcr3_off050.157NoNoNoNo46
1183x52 I2x53 cxcr3_off3.2822342.6525YesYesNoNo56
1193x48 3x52 cxcr3_off1.083713.9145NoNoYesYes65
1203x48 5x57 cxcr3_off0.98998712.406NoNoYesNo67
1215x53 5x57 cxcr3_off1.4870321.9806NoNoYesNo77
1223x44 5x53 cxcr3_off1.2394218.8684NoNoNoNo77
1233x44 5x50 cxcr3_off0.99171115.7466NoNoNoYes79
1243x51 3x52 cxcr3_off1.5344522.9181YesYesYesYes85
1253x51 5x57 cxcr3_off1.1634512.6725YesYesYesNo87
1264x61 E2x52 cxcr3_off0.44841511.6779YesNoYesYes43
1276x51 6x55 cxcr3_off0.67781626.5299YesYesNoNo65
1285x40 6x55 cxcr3_off0.22730512.2966YesYesNoNo35
1296x55 6x59 cxcr3_off0.22511613.215NoNoNoYes55
1305x47 6x52 cxcr3_off0.059108614.3571YesYesYesNo88
1311x35 Lig cxcr3_off013.7289YesNoYesYes50
1322x60 7x42 cxcr3_off018.778YesYesYesYes56
1338x50 8x53 cxcr3_off011.9539YesYesYesYes85
1341x60 8x53 cxcr3_off1.4015116.1416YesYesYesYes55

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Midway



Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Node1Node2OwnerNet1LinkStrengthNet2LinkStrengthComm1Comm2Node1ShellNode2Shell
1x351x39Shared9.389.381011
1x35Ligcxcr3_off5.8801010
1x362x64cxcr3_off3.7400021
1x381x39Shared3.524.10021
1x392x61Shared2.6741112
1x39LigShared15.786.3151110
2x537x42cxcr3_off8.2101021
2x562x60Shared3.645.4551021
2x567x42cxcr3_off2.501021
2x577x42Shared4.694.6850121
2x602x63cxcr3_off3.3501112
2x60E1x50cxcr3_off8.4301112
2x603x28Shared3.893.891112
2x607x42cxcr3_off4.8201111
2x60LigShared22.5925.481110
2x63E1x50Shared10.0510.051022
3x326x48cxcr3_off5.0101112
3x326x51cxcr3_off5.1601111
3x327x38cxcr3_off2.6401111
3x327x42Shared8.258.771111
3x333x36cxcr3_off6.0400111
3x334x61Shared9.4210.770112
3x363x37Shared7.223.611112
3x365x43cxcr3_off8.201111
3x366x48Shared11.027.0151112
3x366x52cxcr3_off9.0501112
3x375x43Shared5.643.9451121
4x614x65Shared4.078.825122
4x61E2x52Shared5.7514.945121
4x65E2x52Shared15.248.7955121
E2.D195E2.L198cxcr3_off8.1400022
E2.A200E2.H202Shared5.852.930021
E2.F207E2x52Shared9.2810.8355021
5x36E2x52cxcr3_off7.205111
5x36E2.F207Shared9.623.215112
5x406x55Shared2.623.921112
5x406x58Shared8.345.361112
5x406x59Shared8.776.2651112
5x406x62cxcr3_off9.5301112
5x436x52cxcr3_off3.7101112
6x486x51Shared5.795.3051121
6x516x55Shared6.317.571112
6x517x37Shared8.747.491112
6x517x38cxcr3_off3.8201111
6x547x34Shared4.553.0350021
6x547x37Shared3.173.9650022
6x556x59Shared3.073.071122
6x586x61cxcr3_off4.1601122
6x586x62Shared6.653.3251122
6x61E3.R288cxcr3_off8.6901021
6x617x30cxcr3_off3.0401022
6x62E3.R288cxcr3_off7.1501021
7x27E3.R288Shared6.9813.3750111
7x277x30cxcr3_off4.2800112
7x277x31cxcr3_off6.500112
7x34Ligcxcr3_off4.9900110
7x35Ligcxcr3_off15.9500010
7x38LigShared8.513.331110
7x42LigShared28.237.8451110
3x29LigShared2.423.7050110
7x39Ligcxcr3_off2.4200010
1x351x36Shared1.641.641012
7x327x36cxcr3_off1.600012
5x335x37cxcr3_off1.4200112
E2.L198E2.R197cxcr3_off1.2100021
E2.E196E2.R197cxcr3_off1.1600021
7x32Ligcxcr3_off1.0600010
LigNT.S40cxcr3_on_gp04.611101
LigNT.P42cxcr3_on_gp08.4551101
7x24NT.C43cxcr3_on_gp06.370021
1x307x32cxcr3_on_gp04.5850021
1x311x35cxcr3_on_gp07.4650111
1x31Ligcxcr3_on_gp03.3650110
1x352x64cxcr3_on_gp03.151011
1x357x35cxcr3_on_gp05.2551011
1x392x57cxcr3_on_gp012.8951112
1x397x42cxcr3_on_gp06.451111
2x533x32cxcr3_on_gp07.311021
2x603x29cxcr3_on_gp02.811111
2x603x32cxcr3_on_gp04.0051111
2x63E2.H202cxcr3_on_gp09.451021
3x294x61cxcr3_on_gp03.3550112
3x32Ligcxcr3_on_gp019.1851110
3x33E2x52cxcr3_on_gp03.490111
3x33Ligcxcr3_on_gp02.780110
3x36Ligcxcr3_on_gp08.211110
E2.R197Ligcxcr3_on_gp023.0850110
E2.H202Ligcxcr3_on_gp03.0250110
5x39E2x52cxcr3_on_gp04.1050021
E2x52Ligcxcr3_on_gp07.145110
5x336x62cxcr3_on_gp03.920112
5x33Ligcxcr3_on_gp02.920110
5x36Ligcxcr3_on_gp016.0955110
5x407x34cxcr3_on_gp03.7151111
5x40Ligcxcr3_on_gp05.881110
5x43Ligcxcr3_on_gp012.0651110
6x486x52cxcr3_on_gp03.1751122
6x516x52cxcr3_on_gp05.4451112
6x517x34cxcr3_on_gp02.9851111
6x51Ligcxcr3_on_gp011.761110
6x587x30cxcr3_on_gp03.651122
6x587x34cxcr3_on_gp07.6051121
E3.R288Ligcxcr3_on_gp03.130110
7x27Ligcxcr3_on_gp06.3950110
7x387x42cxcr3_on_gp07.6351111
1x247x27cxcr3_on_gp04.460021
1x317x31cxcr3_on_gp03.3250112
2x64Ligcxcr3_on_gp02.9950110
E2.D195E2.R197cxcr3_on_gp03.5750021
5x335x36cxcr3_on_gp09.3450111
6x617x27cxcr3_on_gp02.7051021
NT.P41NT.S40cxcr3_on_gp02.670021
1x307x36cxcr3_on_gp02.620022
7x397x42cxcr3_on_gp02.1750011
NT.C43NT.P44cxcr3_on_gp01.880112
LigNT.C43cxcr3_on_gp01.6351101

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
Id Description
cxcr3_on_gp 8HNK-CXCR3-CXCL11-Gi1/β1/γ2
8HNL-CXCR3-PS372424-Gi1/β1/γ2
cxcr3_off 8K2W-CXCR3-AMG487
Network Difference
Value cxcr3_on_gp cxcr3_off
Imin 2.71 2.44
Number of Linked Nodes 874 246
Number of Specific Nodes 631 (72.20%) 3  (1.22%)
Number of Shared Nodes 243 (27.80%) 243  (98.78%)
Number of Links 1092 288
Number of Specific Links 928 (84.98%) 124  (43.06%)
Number of Shared Links 164 (15.02%) 164  (56.94%)
Number of Hubs 179 38
Number of Specific Hubs 152 (84.92%) 11  (28.95%)
Number of Shared Hubs 27 (15.08%) 27  (71.05%)
Average % Shared Neighbours (Jaccard) 12.50
Average % Shared Neighbours (Otsuka) 15.44
Average % Shared Neighbours (Overlap Coefficient) 18.30
Average % Shared Cliques (k3-6) 50.74
Graphlets Similarity 0.756066
Paths Difference
Value cxcr3_on_gp cxcr3_off
Number Of Nodes in MetaPath 71 62
Specific Nodes in MetaPath 62 (87.32%) 53  (85.48%)
Shared Nodes in MetaPath 243 (27.80%) 243  (27.80%)
Number Of Links MetaPath 75 64
Specific Links in MetaPath 70 (93.33%) 59  (92.19%)
Shared Links in MetaPath 164 (15.02%) 164  (15.02%)
Number of Shortest Paths 2679544 41103
Length Of Smallest Path 3 3
Average Path Length 30.7753 12.5608
Length of Longest Path 51 26
Minimum Path Strength 0.7875 1.185
Average Path Strength 5.34146 5.59717
Maximum Path Strength 21.415 22.09
Minimum Path Correlation 0.7 0.7
Average Path Correlation 0.98994 0.907117
Maximum Path Correlation 1 0.99
Minimum % Of Corr. Nodes 2.77778 4.7619
Average % Of Corr. Nodes 36.7409 42.2508
Maximum % Of Corr. Nodes 100 100
Minimum Path Hubs % 0 0
Average Path Hubs % 46.3115 47.5755
Maximum Path Hubs % 100 100

Details about the values in these tables can be found in the corresponding documentation page .

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download cxcr3_off_on_gp.zip<



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