psnGPCR

Press and hold down the left mouse button and move the mouse to rotate.
Press and hold down the central mouse button and move the mouse to translate.
Use the mouse wheel to zoom in or out.
Click on any atom on your molecule and the corresponding residue label will be placed beneath the viewer.

Orange: nodes, hubs and links specific of cxcr4_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of cxcr4_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	cxcr4_off Int. Strength	cxcr4_on Int. Strength	cxcr4_off Hub1?	cxcr4_on Hub1?	cxcr4_off Hub2?	cxcr4_on Hub2?	ConSurf1	ConSurf2
1	Lig	NT.M24	cxcr4_off	4.73	0	Yes	Yes	No	No	0	2
2	1x24	7x28	cxcr4_off	6.42667	0	No	No	No	No	5	3
3	1x24	Lig	cxcr4_off	5.90667	0	No	No	Yes	Yes	5	0
4	1x26	7x28	cxcr4_off	4.82	0	No	No	No	No	4	3
5	1x30	1x31	cxcr4_off	4.02667	0	Yes	No	No	No	4	3
6	1x36	2x65	cxcr4_off	4.71	0	No	No	No	No	5	4
7	1x39	2x60	cxcr4_off	6.75333	0	Yes	Yes	Yes	Yes	7	7
8	1x39	7x39	cxcr4_off	4.44667	0	Yes	Yes	No	No	7	4
9	1x43	1x47	cxcr4_off	5.44333	0	No	No	Yes	No	6	5
10	1x53	7x50	cxcr4_off	3.53	0	No	No	Yes	No	8	9
11	1x54	2x51	cxcr4_off	4.75667	0	No	No	No	No	7	7
12	1x57	7x53	cxcr4_off	3.99	0	No	Yes	Yes	Yes	6	9
13	2x39	3x50	cxcr4_off	3.87667	0	No	No	Yes	No	7	9
14	2x43	7x49	cxcr4_off	10.85	0	No	Yes	No	No	8	9
15	2x43	7x53	cxcr4_off	23.6667	0	No	Yes	Yes	Yes	8	9
16	2x50	3x35	cxcr4_off	4.49	0	No	No	Yes	No	9	8
17	2x52	3x31	cxcr4_off	5.70667	0	No	No	No	No	7	5
18	2x53	2x57	cxcr4_off	5.27667	0	Yes	Yes	No	No	7	8
19	2x53	3x35	cxcr4_off	12.0833	0	Yes	Yes	Yes	No	7	8
20	2x56	3x28	cxcr4_off	4.23	0	No	No	No	No	6	5
21	2x59	3x28	cxcr4_off	3.49333	0	No	No	No	No	6	5
22	2x60	7x38	cxcr4_off	5.81333	0	Yes	Yes	Yes	No	7	5
23	2x60	7x42	cxcr4_off	5.68	0	Yes	Yes	Yes	Yes	7	7
24	2x63	E1x50	cxcr4_off	5.58333	0	No	No	Yes	Yes	5	9
25	2x63	Lig	cxcr4_off	12.4567	0	No	No	Yes	Yes	5	0
26	3x28	E1x50	cxcr4_off	4.08667	0	No	No	Yes	Yes	5	9
27	E1x50	E2.V177	cxcr4_off	4.49333	0	Yes	Yes	No	No	9	4
28	3x29	E2x52	cxcr4_off	5.26333	0	Yes	Yes	Yes	No	6	5
29	3x32	3x36	cxcr4_off	9.38	0	Yes	Yes	No	No	6	7
30	3x32	7x38	cxcr4_off	4.86333	0	Yes	Yes	Yes	No	6	5
31	3x33	4x57	cxcr4_off	4.18667	0	No	No	No	No	5	6
32	3x35	3x39	cxcr4_off	3.47667	0	Yes	No	No	No	8	9
33	3x35	7x45	cxcr4_off	5.1	0	Yes	No	Yes	No	8	9
34	3x36	5x43	cxcr4_off	4.28667	0	No	No	No	No	7	4
35	3x39	6x44	cxcr4_off	4.84	0	No	No	Yes	No	9	9
36	3x40	6x44	cxcr4_off	4.36667	0	No	No	Yes	No	7	9
37	3x41	3x44	cxcr4_off	3.45667	0	No	No	No	No	5	7
38	3x41	5x50	cxcr4_off	16.6633	0	No	No	No	No	5	9
39	3x43	6x41	cxcr4_off	6.18333	0	No	No	No	No	8	7
40	3x43	6x44	cxcr4_off	8.12333	0	No	No	Yes	No	8	9
41	3x45	4x44	cxcr4_off	3.49333	0	Yes	Yes	No	No	5	2
42	3x46	6x37	cxcr4_off	4.56	0	No	No	No	No	8	7
43	3x48	5x53	cxcr4_off	3.47667	0	No	No	No	No	6	6
44	3x49	3x50	cxcr4_off	4.36667	0	Yes	No	Yes	No	8	9
45	3x50	6x32	cxcr4_off	4.95333	0	Yes	No	No	No	9	8
46	3x51	3x52	cxcr4_off	4.69	0	Yes	Yes	No	No	8	5
47	4x46	4x50	cxcr4_off	4.82	0	No	No	Yes	No	7	9
48	4x57	4x62	cxcr4_off	3.89	0	No	No	No	No	6	4
49	E2.E179	E2.Y184	cxcr4_off	8.98	0	No	No	No	No	2	5
50	E2.D181	Lig	cxcr4_off	8.97	0	No	No	Yes	Yes	2	0
51	E2.R183	Lig	cxcr4_off	3.80667	0	Yes	No	Yes	Yes	3	0
52	E2.I185	E2x51	cxcr4_off	5.83667	0	No	No	No	No	3	3
53	5x58	5x62	cxcr4_off	4.83333	0	No	Yes	No	No	8	4
54	6x44	7x45	cxcr4_off	9.05	0	Yes	No	Yes	No	9	9
55	6x48	6x51	cxcr4_off	6.75333	0	Yes	Yes	Yes	Yes	9	7
56	6x58	7x30	cxcr4_off	3.40667	0	No	No	Yes	No	5	5
57	6x60	E3.I269	cxcr4_off	11.7267	0	No	No	No	No	4	1
58	6x64	E3.K271	cxcr4_off	6.75	0	No	No	No	No	2	3
59	7x27	Lig	cxcr4_off	9.12667	0	No	No	Yes	Yes	2	0
60	7x31	Lig	cxcr4_off	5.94667	0	No	Yes	Yes	Yes	4	0
61	7x45	7x46	cxcr4_off	4.91333	0	Yes	No	No	No	9	9
62	7x49	7x50	cxcr4_off	4.89	0	No	No	Yes	No	9	9
63	1x30	1x35	cxcr4_off	4.06	0	Yes	No	Yes	Yes	4	6
64	2x40	7x53	cxcr4_off	3.45	0	No	No	Yes	Yes	8	9
65	E2x52	Lig	cxcr4_off	11.17	0	Yes	No	Yes	Yes	5	0
66	5x40	Lig	cxcr4_off	7.5	0	No	No	Yes	Yes	5	0
67	7x24	7x27	cxcr4_off	3.54667	0	No	No	No	No	5	2
68	7x32	7x33	cxcr4_off	4.25333	0	No	No	No	No	2	6
69	1x56	1x60	cxcr4_off	3.34333	0	No	No	No	No	7	4
70	7x43	7x47	cxcr4_off	3.26	0	No	No	No	No	5	7
71	Lig	NT.K25	cxcr4_off	3.18667	0	Yes	Yes	No	No	0	4
72	3x48	5x57	cxcr4_off	3.17333	0	No	No	No	No	6	6
73	1x25	NT.F29	cxcr4_off	3.11	0	No	No	No	No	5	4
74	1x54	2x48	cxcr4_off	3.07333	0	No	No	No	No	7	5
75	6x61	7x30	cxcr4_off	3.07333	0	No	No	Yes	No	3	5
76	1x46	2x54	cxcr4_off	3.06667	0	No	No	No	No	8	6
77	2x49	4x50	cxcr4_off	3.02333	0	No	No	Yes	No	8	9
78	2x42	4x45	cxcr4_off	2.94333	0	Yes	Yes	No	No	7	5
79	5x54	6x41	cxcr4_off	2.94333	0	No	No	No	No	7	7
80	5x44	5x48	cxcr4_off	2.94	0	No	No	No	No	5	4
81	6x54	7x34	cxcr4_off	2.94	0	No	No	No	No	4	4
82	2x41	I1x51	cxcr4_off	2.88667	0	No	No	No	No	6	0
83	3x43	6x40	cxcr4_off	2.77	0	No	No	No	No	8	7
84	4x42	4x43	cxcr4_off	2.7	0	No	No	No	No	7	3
85	5x33	Lig	cxcr4_off	2.61	0	No	No	Yes	Yes	1	0
86	1x26	7x25	cxcr4_off	2.53667	0	No	No	No	No	4	3
87	3x37	5x461	cxcr4_off	2.41667	0	Yes	Yes	No	No	7	5
88	8x49	8x51	cxcr4_off	2.39333	0	No	No	No	No	0	0
89	1x38	7x40	cxcr4_off	2.38	0	No	No	No	No	5	7
90	6x63	E3.I269	cxcr4_off	2.38	0	No	No	No	No	1	1
91	1x42	2x57	cxcr4_off	2.37667	0	No	No	No	No	7	8
92	5x61	6x34	cxcr4_off	2.37667	0	Yes	No	No	No	8	5
93	6x30	I3.G231	cxcr4_off	2.32667	0	No	No	No	No	7	4
94	1x58	2x44	cxcr4_off	2.28	0	No	No	No	No	2	5
95	3x41	5x49	cxcr4_off	2.28	0	No	No	No	No	5	6
96	4x38	I2x54	cxcr4_off	2.26	0	No	No	No	No	6	5
97	6x49	6x50	cxcr4_off	2.18667	0	No	No	No	No	5	9
98	5x41	5x45	cxcr4_off	2.07333	0	No	No	No	No	4	4
99	1x47	2x54	cxcr4_off	2.05	0	Yes	No	No	No	5	6
100	3x34	4x50	cxcr4_off	2.04333	0	No	No	Yes	No	5	9
101	7x43	7x48	cxcr4_off	2.03	0	No	No	No	No	5	6
102	1x48	1x52	cxcr4_off	1.98667	0	No	No	No	No	4	5
103	1x29	1x33	cxcr4_off	1.88667	0	No	No	No	No	3	5
104	I1x49	I1x50	cxcr4_off	1.88	0	No	No	No	No	0	0
105	6x33	6x36	cxcr4_off	1.87	0	No	No	No	No	7	7
106	5x38	5x39	cxcr4_off	1.74667	0	No	No	Yes	Yes	3	5
107	2x65	2x66	cxcr4_off	1.7	0	No	No	No	No	4	5
108	5x58	6x38	cxcr4_off	1.68333	0	No	Yes	No	No	8	4
109	3x50	5x61	cxcr4_off	1.67	0	Yes	No	Yes	No	9	8
110	3x52	I2x56	cxcr4_off	1.64	0	No	No	No	No	5	4
111	7x47	7x51	cxcr4_off	1.63667	0	No	No	No	No	7	6
112	NT.E26	NT.P27	cxcr4_off	1.57	0	No	No	No	No	2	5
113	1x47	1x48	cxcr4_off	1.54	0	Yes	No	No	No	5	4
114	1x47	2x55	cxcr4_off	1.47	0	Yes	No	No	No	5	4
115	6x53	6x57	cxcr4_off	1.47	0	No	No	No	No	6	5
116	2x38	2x41	cxcr4_off	1.44	0	Yes	Yes	No	No	6	6
117	6x31	6x33	cxcr4_off	1.38333	0	No	No	No	No	5	7
118	Lig	NT.S23	cxcr4_off	1.31667	0	Yes	Yes	No	No	0	2
119	1x55	1x59	cxcr4_off	1.17	0	No	No	No	No	4	5
120	1x51	2x51	cxcr4_off	1.14	0	No	No	No	No	3	7
121	1x28	1x32	cxcr4_off	1.07333	0	No	No	No	No	1	4
122	6x55	6x59	cxcr4_off	1.03333	0	No	No	No	No	5	5
123	7x29	7x32	cxcr4_off	1	0	No	No	No	No	2	2
124	7x54	7x55	cxcr4_off	0.923333	0	No	No	No	No	7	0
125	7x55	8x48	cxcr4_off	0.923333	0	No	No	No	No	0	0
126	1x59	1x60	cxcr4_off	0.753333	0	No	No	No	No	5	4
127	5x51	5x54	cxcr4_off	0.586667	0	No	No	No	No	6	7
128	6x32	I2x50	cxcr4_off	0.536667	0	No	No	No	No	8	8
129	4x44	4x47	cxcr4_off	0.533333	0	No	No	No	No	2	4
130	3x24	3x27	cxcr4_off	0.526667	0	No	No	No	No	5	4
131	1x58	1x59	cxcr4_off	0.483333	0	No	No	No	No	2	5
132	6x30	6x32	cxcr4_off	0.48	0	No	No	No	No	7	8
133	I1x48	I1x51	cxcr4_off	0.413333	0	No	No	No	No	0	0
134	7x53	7x56	cxcr4_off	0.39	0	Yes	Yes	No	No	9	0
135	Lig	NT.P27	Shared	12.38	13.38	Yes	Yes	No	No	0	5
136	7x24	NT.C28	Shared	4.85333	7.28	No	No	No	No	5	9
137	Lig	NT.F29	Shared	4.8	11.73	Yes	Yes	No	No	0	4
138	1x27	7x28	Shared	4.08667	4.09	No	No	No	No	6	3
139	1x27	7x31	Shared	3.4	12.75	No	No	No	Yes	6	4
140	1x30	1x34	Shared	5	9.65	Yes	No	No	No	4	5
141	1x30	7x32	Shared	5.37667	3.72	Yes	No	No	No	4	2
142	1x30	7x36	Shared	4.60333	5.02	Yes	No	No	No	4	6
143	1x31	1x35	Shared	4.57667	4.12	No	No	Yes	Yes	3	6
144	1x35	1x39	Shared	6.64333	7.03	Yes	Yes	Yes	Yes	6	7
145	1x39	7x42	Shared	5.84667	6.19	Yes	Yes	Yes	Yes	7	7
146	1x42	7x43	Shared	5.02333	13.82	No	No	No	No	7	5
147	1x43	2x58	Shared	9.63	7.22	No	No	No	No	6	9
148	1x45	7x47	Shared	5.63333	5.07	No	No	No	No	5	7
149	1x49	7x50	Shared	4.06	4.06	No	No	Yes	No	8	9
150	1x50	2x47	Shared	3.97333	2.98	Yes	Yes	No	No	9	9
151	1x50	2x50	Shared	8.52667	9.42	Yes	Yes	No	No	9	9
152	1x50	7x50	Shared	9.77333	4.89	Yes	Yes	Yes	No	9	9
153	1x53	2x47	Shared	7.54	6.46	No	No	No	No	8	9
154	1x57	2x40	Shared	6.47	6.93	No	Yes	No	No	6	8
155	1x57	2x44	Shared	4.24	2.83	No	Yes	No	No	6	5
156	2x37	2x40	Shared	9.32333	7.36	No	No	No	No	7	8
157	2x38	3x49	Shared	5.54333	5.54	Yes	Yes	Yes	No	6	8
158	2x38	I2x57	Shared	7.44333	6.2	Yes	Yes	Yes	Yes	6	6
159	2x42	3x45	Shared	6.87667	5.16	Yes	Yes	Yes	Yes	7	5
160	2x42	3x46	Shared	5.64	6.04	Yes	Yes	No	No	7	8
161	2x42	3x49	Shared	6.89667	13.79	Yes	Yes	Yes	No	7	8
162	2x42	4x41	Shared	4.89333	4	Yes	Yes	No	No	7	3
163	2x45	4x45	Shared	7.38	4.15	No	No	No	No	9	5
164	2x45	4x46	Shared	5.80667	4.36	No	No	No	No	9	7
165	2x45	4x50	Shared	9.16667	7.41	No	No	Yes	No	9	9
166	2x46	3x42	Shared	4.76	4.28	No	No	No	No	9	7
167	2x46	7x49	Shared	8.24	8.24	No	No	No	No	9	9
168	2x50	7x46	Shared	6.22667	6.22	No	No	No	No	9	9
169	2x53	3x32	Shared	5.16	6.19	Yes	Yes	Yes	Yes	7	6
170	2x53	7x42	Shared	11.79	6.43	Yes	Yes	Yes	Yes	7	7
171	2x56	3x31	Shared	6.08	3.04	No	No	No	No	6	5
172	2x59	E1x52	Shared	12.86	10.72	No	No	Yes	Yes	6	7
173	2x60	3x32	Shared	8.68333	9.65	Yes	Yes	Yes	Yes	7	6
174	2x60	Lig	Shared	11.6367	27.18	Yes	Yes	Yes	Yes	7	0
175	2x62	E1x52	Shared	5.24	6.55	No	No	Yes	Yes	5	7
176	2x63	E2.R183	Shared	4.76333	8.34	No	No	Yes	No	5	3
177	2x66	E1x51	Shared	3.55667	4	No	No	No	No	5	3
178	E1x49	E1x51	Shared	9.69333	15.12	No	No	No	No	4	3
179	E1x49	E2.R183	Shared	6.83333	2.41	No	No	Yes	No	4	3
180	E1x49	E2.Y184	Shared	6.20333	2.33	No	No	No	No	4	5
181	E1x50	E1x52	Shared	14.0333	18.04	Yes	Yes	Yes	Yes	9	7
182	3x25	E1x50	Shared	5.22333	7.84	No	Yes	Yes	Yes	9	9
183	E1x50	E2x50	Shared	13.9333	11.75	Yes	Yes	No	No	9	9
184	3x22	E2.N176	Shared	6.35667	4.09	No	No	No	No	3	4
185	3x22	E2.V177	Shared	6.40333	7.39	No	No	No	No	3	4
186	3x25	E2.V177	Shared	3.42	3.42	No	Yes	No	No	9	4
187	3x25	E2x50	Shared	7.28	7.28	No	Yes	No	No	9	9
188	3x26	E2.N176	Shared	4.2	1.4	No	No	No	No	7	4
189	3x29	4x61	Shared	5.46	7.56	Yes	Yes	No	Yes	6	4
190	3x29	4x65	Shared	7.31667	5.85	Yes	Yes	No	No	6	4
191	3x29	Lig	Shared	6.18667	5.24	Yes	Yes	Yes	Yes	6	0
192	3x30	4x57	Shared	8.99	4.76	No	No	No	No	5	6
193	3x30	4x62	Shared	9.61667	6.55	No	No	No	No	5	4
194	3x32	7x42	Shared	5.84667	6.19	Yes	Yes	Yes	Yes	6	7
195	3x33	4x61	Shared	10.5967	7.23	No	No	No	Yes	5	4
196	3x37	4x56	Shared	8.59667	5.86	Yes	Yes	No	No	7	5
197	3x37	5x43	Shared	6.16667	8.71	Yes	Yes	No	No	7	4
198	3x37	5x46	Shared	5.89	6.31	Yes	Yes	No	No	7	4
199	3x38	4x50	Shared	5.35667	9.88	No	No	Yes	No	7	9
200	3x40	5x50	Shared	6.48	3.53	No	No	No	No	7	9
201	3x45	4x40	Shared	6.09	2.44	Yes	Yes	No	No	5	4
202	3x45	4x49	Shared	5.24333	3.93	Yes	Yes	No	Yes	5	7
203	3x47	5x54	Shared	9.29	9.29	No	No	No	No	9	7
204	3x47	5x57	Shared	3.44	6.89	No	No	No	No	9	6
205	3x49	I2x57	Shared	13.4967	15.48	Yes	No	Yes	Yes	8	6
206	3x51	3x55	Shared	6.31	11.36	Yes	Yes	No	No	8	7
207	3x51	3x56	Shared	7.26	5.44	Yes	Yes	No	No	8	6
208	3x51	5x60	Shared	4.03	9.67	Yes	Yes	No	No	8	4
209	3x52	I2x57	Shared	4.04667	3.64	No	No	Yes	Yes	5	6
210	3x53	I2x57	Shared	6.91	6.91	No	No	Yes	Yes	8	6
211	3x55	3x56	Shared	8.30333	4.15	No	No	No	No	7	6
212	3x55	5x64	Shared	4.55333	6.07	No	No	No	No	7	4
213	I2x55	I2x56	Shared	3.84	1.44	No	No	No	No	5	4
214	4x38	4x42	Shared	13.05	4.05	No	No	No	No	6	7
215	4x40	4x44	Shared	3.97333	4.47	No	No	No	No	4	2
216	4x45	4x46	Shared	5.05	3.79	No	No	No	No	5	7
217	4x48	4x52	Shared	4.06	4.06	No	No	No	No	3	4
218	4x51	4x52	Shared	3.39	5.08	No	No	No	No	4	4
219	4x56	5x42	Shared	3.99	7.99	No	No	No	No	5	3
220	4x59	4x60	Shared	3.95333	3.39	No	No	No	No	3	8
221	4x60	E2x52	Shared	4.80667	7.21	No	No	Yes	No	8	5
222	4x60	5x39	Shared	7.70333	8.67	No	No	Yes	Yes	8	5
223	4x61	E2x52	Shared	10.72	10.72	No	Yes	Yes	No	4	5
224	4x63	4x64	Shared	10.8833	12.56	No	No	No	No	3	4
225	4x64	E2.Y190	Shared	12.0367	8.25	No	No	Yes	Yes	4	4
226	4x64	5x35	Shared	7.01667	5.01	No	No	Yes	Yes	4	5
227	E2.F189	E2.S178	Shared	4.40667	9.25	No	No	No	No	3	1
228	E2.A180	E2.I185	Shared	4.33333	1.62	No	No	No	No	1	3
229	E2.I185	E2.R183	Shared	5.84667	3.76	No	No	Yes	No	3	3
230	E2.F189	E2x51	Shared	5.11333	4.78	No	No	No	No	3	3
231	E2x51	Lig	Shared	8.92333	12.39	No	No	Yes	Yes	3	0
232	E2.Y190	E2x52	Shared	13.72	13.38	Yes	Yes	Yes	No	4	5
233	5x35	E2.Y190	Shared	4.17667	3.86	Yes	Yes	Yes	Yes	5	4
234	5x36	E2.Y190	Shared	4.20667	6.31	No	No	Yes	Yes	4	4
235	5x39	E2.Y190	Shared	5.50333	12.38	Yes	Yes	Yes	Yes	5	4
236	5x35	E2.P191	Shared	14.4133	14.86	Yes	Yes	No	No	5	5
237	5x34	E2.N192	Shared	5.95	1.37	No	No	No	Yes	2	1
238	5x35	E2.N192	Shared	6.40333	7.91	Yes	Yes	No	Yes	5	1
239	5x35	5x39	Shared	4.67667	5.01	Yes	Yes	Yes	Yes	5	5
240	5x43	6x52	Shared	4.35667	10.89	No	No	No	Yes	4	8
241	5x45	5x48	Shared	5.83	4.37	No	No	No	No	4	4
242	5x45	5x49	Shared	4.24	4.24	No	No	No	No	4	6
243	5x47	6x52	Shared	15.24	9.38	No	No	No	Yes	8	8
244	6x39	7x52	Shared	4.76	1.43	No	No	No	Yes	5	7
245	6x40	7x52	Shared	3.69	4.15	No	No	No	Yes	7	7
246	6x43	7x48	Shared	4.73	1.58	No	No	No	No	6	6
247	6x44	6x45	Shared	6.43	9.65	Yes	No	No	No	9	4
248	6x44	6x48	Shared	8.35333	7.02	Yes	No	Yes	Yes	9	9
249	6x48	6x52	Shared	5.46667	8.68	Yes	Yes	No	Yes	9	8
250	6x48	7x41	Shared	7.34667	2.59	Yes	Yes	No	No	9	8
251	6x48	7x45	Shared	11.9867	12.7	Yes	Yes	Yes	No	9	9
252	6x50	7x37	Shared	3.5	5.25	No	No	No	No	9	6
253	6x51	6x55	Shared	9.26667	9.67	Yes	Yes	No	No	7	5
254	6x51	7x37	Shared	4.16333	3.75	Yes	Yes	No	No	7	6
255	6x51	7x38	Shared	11.2267	16.83	Yes	Yes	Yes	No	7	5
256	6x57	7x30	Shared	4.09333	3.07	No	No	Yes	No	5	5
257	6x58	7x34	Shared	4.66667	4.2	No	No	No	No	5	4
258	6x58	Lig	Shared	9.74	5.96	No	No	Yes	Yes	5	0
259	6x62	Lig	Shared	6.87	6.07	No	No	Yes	Yes	3	0
260	7x26	E3.Q272	Shared	8.97667	7.03	No	No	No	No	1	2
261	7x33	7x37	Shared	6.46667	12.13	No	No	No	No	6	6
262	7x38	7x42	Shared	6.60667	12.83	Yes	No	Yes	Yes	5	7
263	7x38	Lig	Shared	9.37667	14.88	Yes	No	Yes	Yes	5	0
264	Lig	Lig	Shared	190.867	532.09	Yes	Yes	Yes	Yes	0	0
265	3x32	Lig	Shared	9.27667	11.13	Yes	Yes	Yes	Yes	6	0
266	E2.F189	Lig	Shared	10.9733	14.97	No	No	Yes	Yes	3	0
267	7x31	7x35	Shared	3.25333	6.97	No	Yes	No	No	4	5
268	6x47	7x48	Shared	3.17333	1.59	No	No	No	No	8	6
269	E2.D181	E2.D182	Shared	3.10333	10.65	No	No	No	No	2	6
270	I2x53	I2x57	Shared	3.07333	5.27	No	No	Yes	Yes	5	6
271	3x42	4x49	Shared	3.07333	4.61	No	No	No	Yes	7	7
272	7x26	7x30	Shared	3.05667	5.24	No	No	Yes	No	1	5
273	6x61	E3.I270	Shared	2.94667	4.42	No	No	No	No	3	5
274	6x60	E3.I270	Shared	2.93333	2.51	No	No	No	No	4	5
275	1x34	1x38	Shared	2.93	3.77	No	No	No	No	5	5
276	2x38	4x38	Shared	2.88	2.88	Yes	Yes	No	No	6	6
277	7x55	8x50	Shared	2.85667	6.43	No	No	No	Yes	0	0
278	2x54	7x46	Shared	2.85	3.42	No	No	No	No	6	9
279	4x39	4x43	Shared	2.82	2.82	No	No	No	No	4	3
280	6x35	6x36	Shared	2.79	1.5	No	No	No	No	6	7
281	1x50	2x51	Shared	2.75	2.75	Yes	Yes	No	No	9	7
282	1x39	2x61	Shared	2.66667	2.67	Yes	Yes	No	No	7	7
283	I3.G231	I3.H232	Shared	2.65	1.59	No	No	No	No	4	4
284	3x47	5x58	Shared	2.54333	12.72	No	No	No	Yes	9	8
285	3x24	E1x52	Shared	2.44	6.09	No	No	Yes	Yes	5	7
286	1x35	2x64	Shared	2.10333	1.58	Yes	Yes	No	No	6	5
287	1x41	1x45	Shared	2.02667	1.52	No	No	No	No	4	5
288	3x45	4x48	Shared	2.01	3.01	Yes	Yes	No	No	5	3
289	6x38	6x42	Shared	1.98667	2.98	No	No	No	No	4	5
290	3x54	5x61	Shared	1.96	5.89	No	No	Yes	No	8	8
291	5x48	5x52	Shared	1.96	1.47	No	No	No	No	4	3
292	6x35	6x39	Shared	1.93667	1.45	No	No	No	No	6	5
293	5x61	5x65	Shared	1.90333	2.85	Yes	No	No	No	8	8
294	4x51	4x55	Shared	1.90333	1.43	No	No	No	No	4	4
295	3x21	E1x50	Shared	1.87333	1.41	No	No	Yes	Yes	8	9
296	3x23	3x24	Shared	1.62667	2.44	No	No	No	No	1	5
297	1x32	2x65	Shared	1.52	3.04	No	No	No	No	4	4
298	1x37	1x41	Shared	1.52	1.52	No	No	No	No	4	4
299	I2x51	I2x52	Shared	1.46333	5.85	No	No	No	No	5	5
300	3x38	4x53	Shared	1.14	1.71	No	No	No	No	7	7
301	5x52	5x56	Shared	1.03333	1.55	No	No	No	No	3	3
302	3x34	4x54	Shared	0.993333	2.98	No	No	No	No	5	3
303	5x37	6x62	Shared	0.993333	4.47	No	No	No	No	3	3
304	1x32	1x33	Shared	0.966667	4.36	No	No	No	No	4	5
305	3x56	I2x52	Shared	0.85	5.1	No	No	No	No	6	5
306	7x23	E3.Q272	Shared	0.546667	1.64	No	No	No	No	5	2
307	5x44	6x56	Shared	0.516667	1.55	No	No	No	No	5	5
308	1x39	Lig	cxcr4_on	0	4.05	Yes	Yes	Yes	Yes	7	0
309	7x42	Lig	cxcr4_on	0	5.78	Yes	Yes	Yes	Yes	7	0
310	6x51	Lig	cxcr4_on	0	3.79	Yes	Yes	Yes	Yes	7	0
311	6x55	Lig	cxcr4_on	0	4.61	No	No	Yes	Yes	5	0
312	1x35	Lig	cxcr4_on	0	4.27	Yes	Yes	Yes	Yes	6	0
313	7x35	Lig	cxcr4_on	0	4.89	No	No	Yes	Yes	5	0
314	6x64	Lig	cxcr4_on	0	11.65	No	No	Yes	Yes	2	0
315	E2.I185	Lig	cxcr4_on	0	8.47	No	No	Yes	Yes	3	0
316	NT.E26	NT.K25	cxcr4_on	0	9.45	No	No	No	No	2	4
317	NT.F29	NT.P27	cxcr4_on	0	8.67	No	No	No	No	4	5
318	7x27	NT.C28	cxcr4_on	0	6.08	No	No	No	No	2	9
319	1x24	7x31	cxcr4_on	0	15.8	No	No	No	Yes	5	4
320	1x27	7x32	cxcr4_on	0	8.39	No	No	No	No	6	2
321	1x29	1x32	cxcr4_on	0	6.99	No	No	No	No	3	4
322	1x31	7x31	cxcr4_on	0	3.83	No	No	No	Yes	3	4
323	1x31	7x35	cxcr4_on	0	5.96	No	No	No	No	3	5
324	1x47	2x51	cxcr4_on	0	4.28	Yes	No	No	No	5	7
325	1x53	8x50	cxcr4_on	0	3.93	No	No	No	Yes	8	0
326	1x54	2x47	cxcr4_on	0	4.64	No	No	No	No	7	9
327	1x56	8x50	cxcr4_on	0	9.18	No	No	No	Yes	7	0
328	1x57	2x43	cxcr4_on	0	4.96	No	Yes	No	Yes	6	8
329	1x60	I1x49	cxcr4_on	0	5.42	No	No	No	No	4	0
330	1x60	8x53	cxcr4_on	0	8.66	No	No	No	No	4	0
331	2x44	I1x51	cxcr4_on	0	6.07	No	No	No	No	5	0
332	2x38	4x41	cxcr4_on	0	4.83	Yes	Yes	No	No	6	3
333	2x39	2x43	cxcr4_on	0	5.17	No	No	No	Yes	7	8
334	2x40	2x43	cxcr4_on	0	10.72	No	No	No	Yes	8	8
335	2x41	4x42	cxcr4_on	0	10.8	No	No	No	No	6	7
336	2x43	8x50	cxcr4_on	0	5.34	No	Yes	No	Yes	8	0
337	2x50	7x49	cxcr4_on	0	6.73	No	No	No	No	9	9
338	2x52	3x35	cxcr4_on	0	9.61	No	No	Yes	No	7	8
339	2x53	7x45	cxcr4_on	0	4.53	Yes	Yes	Yes	No	7	9
340	2x53	7x46	cxcr4_on	0	4.19	Yes	Yes	No	No	7	9
341	2x56	2x60	cxcr4_on	0	6.06	No	No	Yes	Yes	6	7
342	2x60	3x28	cxcr4_on	0	4.9	Yes	Yes	No	No	7	5
343	3x25	3x29	cxcr4_on	0	4.42	No	Yes	Yes	Yes	9	6
344	3x31	3x35	cxcr4_on	0	4.25	No	No	Yes	No	5	8
345	3x37	5x42	cxcr4_on	0	4.51	Yes	Yes	No	No	7	3
346	3x39	7x45	cxcr4_on	0	5.58	No	No	Yes	No	9	9
347	3x41	4x49	cxcr4_on	0	4.47	No	No	No	Yes	5	7
348	3x43	7x53	cxcr4_on	0	8.21	No	No	Yes	Yes	8	9
349	3x46	3x50	cxcr4_on	0	5.01	No	No	Yes	No	8	9
350	3x46	7x53	cxcr4_on	0	4.84	No	No	Yes	Yes	8	9
351	3x50	7x53	cxcr4_on	0	5.14	Yes	No	Yes	Yes	9	9
352	3x51	5x57	cxcr4_on	0	5.38	Yes	Yes	No	No	8	6
353	4x39	4x44	cxcr4_on	0	4.47	No	No	No	No	4	2
354	4x49	4x50	cxcr4_on	0	7.36	No	Yes	Yes	No	7	9
355	4x57	4x61	cxcr4_on	0	5.78	No	No	No	Yes	6	4
356	E2.P191	E2.Y190	cxcr4_on	0	4.17	No	No	Yes	Yes	5	4
357	E2.N192	E2.P191	cxcr4_on	0	8.15	No	Yes	No	No	1	5
358	5x37	6x59	cxcr4_on	0	4.85	No	No	No	No	3	5
359	5x37	6x63	cxcr4_on	0	11.92	No	No	No	No	3	1
360	5x39	5x42	cxcr4_on	0	5.86	Yes	Yes	No	No	5	3
361	5x40	6x58	cxcr4_on	0	5.22	No	No	No	No	5	5
362	5x40	6x59	cxcr4_on	0	5.78	No	No	No	No	5	5
363	5x41	6x59	cxcr4_on	0	9.25	No	No	No	No	4	5
364	5x43	6x51	cxcr4_on	0	4.36	No	No	Yes	Yes	4	7
365	5x461	6x52	cxcr4_on	0	4.35	No	No	No	Yes	5	8
366	5x54	5x58	cxcr4_on	0	6.04	No	No	No	Yes	7	8
367	5x55	6x41	cxcr4_on	0	4.28	No	No	No	No	4	7
368	5x55	6x45	cxcr4_on	0	8.53	No	No	No	No	4	4
369	5x58	6x37	cxcr4_on	0	4.99	No	Yes	No	No	8	7
370	5x58	6x40	cxcr4_on	0	7.03	No	Yes	No	No	8	7
371	5x58	6x41	cxcr4_on	0	8.46	No	Yes	No	No	8	7
372	5x62	6x34	cxcr4_on	0	5.71	No	No	No	No	4	5
373	5x62	6x37	cxcr4_on	0	6.08	No	No	No	No	4	7
374	5x65	6x30	cxcr4_on	0	4.23	No	No	No	No	8	7
375	5x66	5x67	cxcr4_on	0	12.55	No	No	No	No	4	5
376	5x68	6x30	cxcr4_on	0	12.24	No	No	No	No	0	7
377	6x40	7x53	cxcr4_on	0	7.03	No	No	Yes	Yes	7	9
378	6x51	6x52	cxcr4_on	0	8.94	Yes	Yes	No	Yes	7	8
379	6x61	7x26	cxcr4_on	0	3.77	No	No	No	No	3	1
380	7x24	7x28	cxcr4_on	0	4.72	No	No	No	No	5	3
381	7x48	7x52	cxcr4_on	0	4.15	No	No	No	Yes	6	7
382	7x54	8x50	cxcr4_on	0	8.32	No	No	No	Yes	7	0
383	1x48	1x49	cxcr4_on	0	3.68	No	No	No	No	4	8
384	3x40	6x48	cxcr4_on	0	3.68	No	No	Yes	Yes	7	9
385	2x53	3x36	cxcr4_on	0	3.65	Yes	Yes	No	No	7	7
386	Lig	NT.E26	cxcr4_on	0	3.49	Yes	Yes	No	No	0	2
387	2x49	3x38	cxcr4_on	0	3.42	No	No	No	No	8	7
388	E2.V177	E2x50	cxcr4_on	0	3.42	No	No	No	No	4	9
389	1x56	8x54	cxcr4_on	0	3.39	No	No	No	No	7	0
390	1x42	7x47	cxcr4_on	0	3.27	No	No	No	No	7	7
391	3x44	5x54	cxcr4_on	0	3.25	No	No	No	No	7	7
392	5x55	5x59	cxcr4_on	0	3.17	No	No	No	No	4	3
393	7x30	7x34	cxcr4_on	0	3.07	Yes	No	No	No	5	4
394	CT.S319	I1x48	cxcr4_on	0	3.06	No	No	No	No	0	0
395	6x31	I3.G231	cxcr4_on	0	3	No	No	No	No	5	4
396	2x48	2x52	cxcr4_on	0	2.98	No	No	No	No	5	7
397	2x54	2x57	cxcr4_on	0	2.98	No	No	No	No	6	8
398	3x34	3x35	cxcr4_on	0	2.96	No	No	Yes	No	5	8
399	1x38	1x42	cxcr4_on	0	2.94	No	No	No	No	5	7
400	5x44	6x55	cxcr4_on	0	2.94	No	No	No	No	5	5
401	6x54	7x33	cxcr4_on	0	2.81	No	No	No	No	4	6
402	1x34	7x39	cxcr4_on	0	2.77	No	No	No	No	5	4
403	3x48	4x40	cxcr4_on	0	2.77	No	No	No	No	6	4
404	5x47	6x49	cxcr4_on	0	2.77	No	No	No	No	8	5
405	1x26	7x32	cxcr4_on	0	2.7	No	No	No	No	4	2
406	5x68	6x31	cxcr4_on	0	2.64	No	No	No	No	0	5
407	1x43	2x54	cxcr4_on	0	2.62	No	No	No	No	6	6
408	6x32	I3.H232	cxcr4_on	0	2.62	No	No	No	No	8	4
409	1x59	CT.V320	cxcr4_on	0	2.52	No	No	No	No	5	0
410	6x31	6x34	cxcr4_on	0	2.43	No	No	No	No	5	5
411	1x46	7x47	cxcr4_on	0	1.96	No	No	No	No	8	7
412	4x47	4x48	cxcr4_on	0	1.84	No	No	No	No	4	3
413	I2x53	I2x56	cxcr4_on	0	1.78	No	No	No	No	5	4
414	6x53	6x54	cxcr4_on	0	1.76	No	No	No	No	6	4
415	1x57	1x58	cxcr4_on	0	1.75	No	Yes	No	No	6	2
416	I3.G231	I3.K230	cxcr4_on	0	1.74	No	No	No	No	4	0
417	1x49	1x52	cxcr4_on	0	1.71	No	No	No	No	8	5
418	5x53	5x57	cxcr4_on	0	1.71	No	No	No	No	6	6
419	1x35	1x36	cxcr4_on	0	1.64	Yes	Yes	No	No	6	5
420	5x49	5x50	cxcr4_on	0	1.64	No	No	No	No	6	9
421	1x56	8x53	cxcr4_on	0	1.62	No	No	No	No	7	0
422	2x64	Lig	cxcr4_on	0	1.58	No	No	Yes	Yes	5	0
423	5x65	6x33	cxcr4_on	0	1.58	No	No	No	No	8	7
424	6x43	7x52	cxcr4_on	0	1.58	No	No	No	Yes	6	7
425	5x60	5x63	cxcr4_on	0	1.55	No	No	No	No	4	4
426	6x56	6x57	cxcr4_on	0	1.55	No	No	No	No	5	5
427	5x62	6x38	cxcr4_on	0	1.54	No	No	No	No	4	4
428	2x55	2x56	cxcr4_on	0	1.52	No	No	No	No	4	6
429	5x51	6x44	cxcr4_on	0	1.51	No	No	Yes	No	6	9
430	5x51	6x45	cxcr4_on	0	1.51	No	No	No	No	6	4
431	8x58	CT.V320	cxcr4_on	0	1.49	No	No	No	No	0	0
432	E3.I269	E3.I270	cxcr4_on	0	1.47	No	No	No	No	1	5
433	7x25	7x29	cxcr4_on	0	1.41	No	No	No	No	3	2
434	5x33	E2.N192	cxcr4_on	0	1.35	No	No	No	Yes	1	1
435	7x51	7x55	cxcr4_on	0	1.26	No	No	No	No	6	0

Orange: nodes, hubs and links specific of cxcr4_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of cxcr4_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	cxcr4_off Avg Int. Strength	cxcr4_on Avg Int. Strength	cxcr4_off Num Of Links	cxcr4_on Num Of Links	ConSurf
1	1x30	cxcr4_off	4.61333	6.13	5	3	4
2	1x47	cxcr4_off	2.62583	4.28	4	1	5
3	3x35	cxcr4_off	6.2875	5.60667	4	3	8
4	3x49	cxcr4_off	7.57583	11.6033	4	3	8
5	3x50	cxcr4_off	3.71667	5.075	4	2	9
6	4x50	cxcr4_off	4.882	8.21667	5	3	9
7	E2.R183	cxcr4_off	5.3125	4.83667	4	3	3
8	E2x52	cxcr4_off	9.136	10.4367	5	3	5
9	5x61	cxcr4_off	1.9775	4.37	4	2	8
10	6x44	cxcr4_off	6.86056	6.06	6	3	9
11	7x30	cxcr4_off	3.4075	3.79333	4	3	5
12	7x38	cxcr4_off	7.57733	14.8467	5	3	5
13	7x45	cxcr4_off	7.7625	7.60333	4	3	9
14	7x50	cxcr4_off	5.56333	4.475	4	2	9
15	1x35	Shared	4.34583	3.728	4	5	6
16	1x39	Shared	5.27133	4.985	5	4	7
17	1x50	Shared	6.25583	5.01	4	4	9
18	2x38	Shared	4.32667	4.8625	4	4	6
19	2x42	Shared	5.45	7.2475	5	4	7
20	2x53	Shared	8.5775	4.998	4	5	7
21	2x60	Shared	7.71333	11.9475	5	4	7
22	E1x50	Shared	7.03238	9.76	7	4	9
23	E1x52	Shared	8.64333	10.35	4	4	7
24	3x29	Shared	6.05667	5.7675	4	4	6
25	3x32	Shared	7.20167	8.29	6	4	6
26	3x37	Shared	5.7675	6.3475	4	4	7
27	3x45	Shared	4.74267	3.635	5	4	5
28	3x51	Shared	5.5725	7.9625	4	4	8
29	I2x57	Shared	6.994	7.5	5	5	6
30	E2.Y190	Shared	7.92867	8.05833	5	6	4
31	5x35	Shared	7.33733	7.33	5	5	5
32	5x39	Shared	4.9075	7.98	4	4	5
33	6x48	Shared	7.98133	6.934	5	5	9
34	6x51	Shared	7.8525	7.89	4	6	7
35	7x42	Shared	7.154	7.484	5	5	7
36	7x53	Shared	7.87417	6.305	4	4	9
37	Lig	Shared	22.8593	56.3496	24	22	0
38	1x57	cxcr4_on	4.9	4.1175	3	4	6
39	2x43	cxcr4_on	17.2583	6.5475	2	4	8
40	3x25	cxcr4_on	5.30778	5.74	3	4	9
41	4x49	cxcr4_on	4.15833	5.0925	2	4	7
42	4x61	cxcr4_on	8.92556	7.8225	3	4	4
43	E2.N192	cxcr4_on	6.17667	4.695	2	4	1
44	5x58	cxcr4_on	3.02	7.848	3	5	8
45	6x52	cxcr4_on	8.35445	8.448	3	5	8
46	7x31	cxcr4_on	4.2	9.8375	3	4	4
47	7x52	cxcr4_on	4.225	2.8275	2	4	7
48	8x50	cxcr4_on	2.85667	6.64	1	5	0

Orange: nodes, hubs and links specific of cxcr4_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of cxcr4_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	cxcr4_off Recurrence	cxcr4_on Recurrence	cxcr4_off Hub1?	cxcr4_on Hub1?	cxcr4_off Hub2?	cxcr4_on Hub2?	ConSurf1	ConSurf2
1	1x35	1x39	cxcr4_off	11.2374	1.32739	Yes	Yes	Yes	Yes	6	7
2	6x51	7x38	cxcr4_off	26.6113	4.14926	Yes	Yes	Yes	No	7	5
3	7x38	Lig	cxcr4_off	23.8457	0.4502	Yes	No	Yes	Yes	5	0
4	E1x49	E2.R183	cxcr4_off	12.8308	6.38169	No	No	Yes	No	4	3
5	E2.R183	Lig	cxcr4_off	14.8534	0	Yes	No	Yes	Yes	3	0
6	1x42	2x57	cxcr4_off	12.9897	0	No	No	No	No	7	8
7	2x53	2x57	cxcr4_off	14.2454	0	Yes	Yes	No	No	7	8
8	1x42	7x43	cxcr4_off	11.7261	1.61515	No	No	No	No	7	5
9	1x47	2x54	cxcr4_off	12.5129	0	Yes	No	No	No	5	6
10	2x54	7x46	cxcr4_off	16.6216	7.45846	No	No	No	No	6	9
11	2x50	3x35	cxcr4_off	83.9625	0	No	No	Yes	No	9	8
12	2x53	3x35	cxcr4_off	64.9686	0	Yes	Yes	Yes	No	7	8
13	7x45	7x46	cxcr4_off	29.222	0	Yes	No	No	No	9	9
14	3x35	7x45	cxcr4_off	26.8378	0	Yes	No	Yes	No	8	9
15	6x48	6x51	cxcr4_off	31.1889	0	Yes	Yes	Yes	Yes	9	7
16	1x50	7x50	cxcr4_off	93.7535	7.45846	Yes	Yes	Yes	No	9	9
17	2x43	7x53	cxcr4_off	15.7792	0	No	Yes	Yes	Yes	8	9
18	2x43	7x49	cxcr4_off	17.2097	0	No	Yes	No	No	8	9
19	7x49	7x50	cxcr4_off	91.417	0	No	No	Yes	No	9	9
20	1x57	7x53	cxcr4_off	10.1446	0	No	Yes	Yes	Yes	6	9
21	2x38	3x49	cxcr4_off	12.4175	7.03147	Yes	Yes	Yes	No	6	8
22	3x49	3x50	cxcr4_off	15.4017	0	Yes	No	Yes	No	8	9
23	2x45	4x45	cxcr4_off	10.1725	1.87506	No	No	No	No	9	5
24	2x42	4x45	cxcr4_off	21.7079	0	Yes	Yes	No	No	7	5
25	4x45	4x46	cxcr4_off	10.1764	0	No	No	No	No	5	7
26	2x63	E1x50	cxcr4_off	21.6363	0	No	No	Yes	Yes	5	9
27	2x63	Lig	cxcr4_off	21.4377	0	No	No	Yes	Yes	5	0
28	E2x52	Lig	cxcr4_off	22.0933	0	Yes	No	Yes	Yes	5	0
29	3x35	3x39	cxcr4_off	15.215	0	Yes	No	No	No	8	9
30	3x40	6x44	cxcr4_off	22.9675	0	No	No	Yes	No	7	9
31	3x40	5x50	cxcr4_off	21.088	7.56985	No	No	No	No	7	9
32	3x41	5x50	cxcr4_off	19.2005	0	No	No	No	No	5	9
33	3x43	6x44	cxcr4_off	36.0089	0	No	No	Yes	No	8	9
34	3x43	6x41	cxcr4_off	21.1953	0	No	No	No	No	8	7
35	3x47	5x54	cxcr4_off	15.505	0.0974659	No	No	No	No	9	7
36	5x54	6x41	cxcr4_off	19.3038	0	No	No	No	No	7	7
37	3x51	3x52	cxcr4_off	10.3711	0	Yes	Yes	No	No	8	5
38	3x52	I2x57	cxcr4_off	14.6984	1.8008	No	No	Yes	Yes	5	6
39	5x45	5x49	cxcr4_off	13.4904	5.08215	No	No	No	No	4	6
40	3x41	5x49	cxcr4_off	15.4017	0	No	No	No	No	5	6
41	6x40	7x52	cxcr4_off	11.6785	8.73016	No	No	No	Yes	7	7
42	3x43	6x40	cxcr4_off	13.5977	0	No	No	No	No	8	7
43	6x58	7x30	cxcr4_off	13.0215	0	No	No	Yes	No	5	5
44	3x39	6x44	cxcr4_off	14.5037	0	No	No	Yes	No	9	9
45	6x44	7x45	cxcr4_off	27.108	0	Yes	No	Yes	No	9	9
46	3x32	Lig	Shared	53.3895	41.4508	Yes	Yes	Yes	Yes	6	0
47	2x53	3x32	Shared	53.8385	47.8511	Yes	Yes	Yes	Yes	7	6
48	2x50	7x46	Shared	26.4325	94.036	No	No	No	No	9	9
49	6x48	7x45	Shared	18.7555	15.873	Yes	Yes	Yes	No	9	9
50	1x50	2x50	Shared	100	47.3777	Yes	Yes	No	No	9	9
51	2x42	3x49	Shared	45.7363	19.289	Yes	Yes	Yes	No	7	8
52	2x42	3x45	Shared	67.77	31.2633	Yes	Yes	Yes	Yes	7	5
53	3x45	4x49	Shared	76.2378	44.7972	Yes	Yes	No	Yes	5	7
54	3x42	4x49	Shared	77.2908	55.1564	No	No	No	Yes	7	7
55	2x46	3x42	Shared	78.3041	56.2749	No	No	No	No	9	7
56	2x46	7x49	Shared	79.3094	57.4028	No	No	No	No	9	9
57	3x49	I2x57	Shared	18.4892	10.5495	Yes	No	Yes	Yes	8	6
58	6x44	6x48	Shared	19.2204	42.7225	Yes	No	Yes	Yes	9	9
59	E2.Y190	E2x52	Shared	11.5513	15.5388	Yes	Yes	Yes	No	4	5
60	6x58	Lig	Shared	16.2481	20.918	No	No	Yes	Yes	5	0
61	1x27	7x31	cxcr4_on	1.07685	29.1841	No	No	No	Yes	6	4
62	7x31	7x35	cxcr4_on	1.2199	31.4768	No	Yes	No	No	4	5
63	7x35	Lig	cxcr4_on	0	34.2755	No	No	Yes	Yes	5	0
64	1x27	7x32	cxcr4_on	0	21.8277	No	No	No	No	6	2
65	1x30	7x32	cxcr4_on	2.90471	18.8202	Yes	No	No	No	4	2
66	1x30	1x34	cxcr4_on	3.67957	15.7755	Yes	No	No	No	4	5
67	1x34	1x38	cxcr4_on	2.45967	12.6938	No	No	No	No	5	5
68	1x38	1x42	cxcr4_on	0	11.139	No	No	No	No	5	7
69	2x53	7x46	cxcr4_on	0	100	Yes	Yes	No	No	7	9
70	2x53	7x42	cxcr4_on	9.55257	47.9903	Yes	Yes	Yes	Yes	7	7
71	7x42	Lig	cxcr4_on	0	41.488	Yes	Yes	Yes	Yes	7	0
72	1x53	2x47	cxcr4_on	1.49805	32.2844	No	No	No	No	8	9
73	1x50	2x47	cxcr4_on	2.67822	35.7143	Yes	Yes	No	No	9	9
74	1x53	8x50	cxcr4_on	0	30.5532	No	No	No	Yes	8	0
75	2x43	8x50	cxcr4_on	0	14.7452	No	Yes	No	Yes	8	0
76	2x50	7x49	cxcr4_on	0	58.5306	No	No	No	No	9	9
77	2x38	4x38	cxcr4_on	7.44656	10.647	Yes	Yes	No	No	6	6
78	2x42	3x46	cxcr4_on	2.8014	13.6731	Yes	Yes	No	No	7	8
79	4x49	4x50	cxcr4_on	0	12.9908	No	Yes	Yes	No	7	9
80	2x56	2x60	cxcr4_on	0	11.8398	No	No	Yes	Yes	6	7
81	2x53	7x45	cxcr4_on	0	17.6552	Yes	Yes	Yes	No	7	9
82	3x25	E1x50	cxcr4_on	1.19208	11.074	No	Yes	Yes	Yes	9	9
83	3x25	3x29	cxcr4_on	0	20.2683	No	Yes	Yes	Yes	9	6
84	3x29	Lig	cxcr4_on	7.71279	47.2153	Yes	Yes	Yes	Yes	6	0
85	E2.I185	Lig	cxcr4_on	0	12.4988	No	No	Yes	Yes	3	0
86	3x29	4x61	cxcr4_on	5.63856	27.4158	Yes	Yes	No	Yes	6	4
87	3x37	5x43	cxcr4_on	9.27442	14.592	Yes	Yes	No	No	7	4
88	6x51	Lig	cxcr4_on	0	39.3855	Yes	Yes	Yes	Yes	7	0
89	6x40	7x53	cxcr4_on	0	14.7962	No	No	Yes	Yes	7	9
90	5x58	6x40	cxcr4_on	0	19.4421	No	Yes	No	No	8	7
91	5x58	6x41	cxcr4_on	0	39.5155	No	Yes	No	No	8	7
92	5x55	6x41	cxcr4_on	0	40.0492	No	No	No	No	4	7
93	5x55	6x45	cxcr4_on	0	41.0517	No	No	No	No	4	4
94	6x44	6x45	cxcr4_on	1.96297	41.1909	Yes	No	No	No	9	4
95	6x48	6x52	cxcr4_on	8.63864	38.6661	Yes	Yes	No	Yes	9	8
96	6x51	6x52	cxcr4_on	0	30.3212	Yes	Yes	No	Yes	7	8
97	3x47	5x58	cxcr4_on	7.81213	13.5246	No	No	No	Yes	9	8
98	3x47	5x57	cxcr4_on	5.873	12.4339	No	No	No	No	9	6
99	3x51	5x57	cxcr4_on	0	10.0204	Yes	Yes	No	No	8	6
100	6x31	6x34	cxcr4_on	0	13.6267	No	No	No	No	5	5
101	5x62	6x34	cxcr4_on	0	14.8102	No	No	No	No	4	5
102	5x62	6x37	cxcr4_on	0	18.305	No	No	No	No	4	7
103	5x58	6x37	cxcr4_on	0	19.4514	No	Yes	No	No	8	7
104	4x61	E2x52	cxcr4_on	5.89684	20.5003	No	Yes	Yes	No	4	5
105	6x51	7x37	cxcr4_on	9.76317	10.1132	Yes	Yes	No	No	7	6
106	6x58	7x34	cxcr4_on	2.43583	15.2047	No	No	No	No	5	4
107	7x26	7x30	cxcr4_on	3.64381	11.074	No	No	Yes	No	1	5
108	7x30	7x34	cxcr4_on	0	13.6963	Yes	No	No	No	5	4
109	3x46	7x53	cxcr4_on	0	12.8098	No	No	Yes	Yes	8	9

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
Lig	NT.M24	cxcr4_off	4.73	0	1	1	0	1
Lig	NT.P27	Shared	12.38	13.38	1	1	0	1
7x24	NT.C28	Shared	4.85333	7.28	0	0	2	2
Lig	NT.F29	Shared	4.8	11.73	1	1	0	1
1x24	7x28	cxcr4_off	6.42667	0	1	0	1	2
1x24	Lig	cxcr4_off	5.90667	0	1	0	1	0
1x27	7x28	Shared	4.08667	4.09	0	0	2	2
1x27	7x31	Shared	3.4	12.75	0	0	2	1
1x30	1x31	cxcr4_off	4.02667	0	1	0	2	2
1x31	1x35	Shared	4.57667	4.12	1	1	2	1
1x35	1x39	Shared	6.64333	7.03	1	1	1	1
1x39	2x60	cxcr4_off	6.75333	0	1	1	1	1
1x39	7x39	cxcr4_off	4.44667	0	1	1	1	2
1x39	7x42	Shared	5.84667	6.19	1	1	1	1
2x53	3x32	Shared	5.16	6.19	1	1	2	1
2x53	7x42	Shared	11.79	6.43	1	1	2	1
2x56	3x28	cxcr4_off	4.23	0	0	0	2	2
2x60	3x32	Shared	8.68333	9.65	1	1	1	1
2x60	7x38	cxcr4_off	5.81333	0	1	1	1	1
2x60	7x42	cxcr4_off	5.68	0	1	1	1	1
2x60	Lig	Shared	11.6367	27.18	1	1	1	0
2x63	E1x50	cxcr4_off	5.58333	0	1	0	1	2
2x63	E2.R183	Shared	4.76333	8.34	1	0	1	1
2x63	Lig	cxcr4_off	12.4567	0	1	0	1	0
E1x49	E2.R183	Shared	6.83333	2.41	0	0	2	1
3x25	E1x50	Shared	5.22333	7.84	1	1	2	2
3x28	E1x50	cxcr4_off	4.08667	0	0	0	2	2
3x29	4x61	Shared	5.46	7.56	1	1	1	2
3x29	4x65	Shared	7.31667	5.85	1	1	1	2
3x29	E2x52	cxcr4_off	5.26333	0	1	1	1	1
3x29	Lig	Shared	6.18667	5.24	1	1	1	0
3x32	3x36	cxcr4_off	9.38	0	1	1	1	2
3x32	7x38	cxcr4_off	4.86333	0	1	1	1	1
3x32	7x42	Shared	5.84667	6.19	1	1	1	1
3x36	5x43	cxcr4_off	4.28667	0	0	0	2	2
4x60	E2x52	Shared	4.80667	7.21	0	0	2	1
4x61	E2x52	Shared	10.72	10.72	1	0	2	1
E2.F189	E2.S178	Shared	4.40667	9.25	1	1	1	2
E2.A180	E2.I185	Shared	4.33333	1.62	0	0	2	1
E2.D181	Lig	cxcr4_off	8.97	0	1	0	1	0
E2.I185	E2.R183	Shared	5.84667	3.76	0	1	1	1
E2.R183	Lig	cxcr4_off	3.80667	0	1	0	1	0
E2.I185	E2x51	cxcr4_off	5.83667	0	0	1	1	1
E2.F189	E2x51	Shared	5.11333	4.78	1	1	1	1
E2x51	Lig	Shared	8.92333	12.39	1	1	1	0
E2.Y190	E2x52	Shared	13.72	13.38	1	1	2	1
5x43	6x52	Shared	4.35667	10.89	0	1	2	2
6x48	6x51	cxcr4_off	6.75333	0	7	0	2	1
6x48	6x52	Shared	5.46667	8.68	7	0	2	2
6x51	6x55	Shared	9.26667	9.67	0	1	1	1
6x51	7x37	Shared	4.16333	3.75	0	1	1	2
6x51	7x38	Shared	11.2267	16.83	0	1	1	1
6x58	7x30	cxcr4_off	3.40667	0	1	1	1	2
6x58	7x34	Shared	4.66667	4.2	1	1	1	2
6x58	Lig	Shared	9.74	5.96	1	1	1	0
6x62	Lig	Shared	6.87	6.07	1	1	1	0
6x64	E3.K271	cxcr4_off	6.75	0	0	0	1	2
7x27	Lig	cxcr4_off	9.12667	0	1	0	1	0
7x31	Lig	cxcr4_off	5.94667	0	1	1	1	0
7x38	7x42	Shared	6.60667	12.83	1	1	1	1
7x38	Lig	Shared	9.37667	14.88	1	1	1	0
1x30	1x35	cxcr4_off	4.06	0	1	0	2	1
3x32	Lig	Shared	9.27667	11.13	1	1	1	0
E2x52	Lig	cxcr4_off	11.17	0	1	0	1	0
E2.F189	Lig	Shared	10.9733	14.97	1	1	1	0
5x40	Lig	cxcr4_off	7.5	0	0	0	1	0
7x24	7x27	cxcr4_off	3.54667	0	0	0	2	1
7x31	7x35	Shared	3.25333	6.97	1	1	1	1
Lig	NT.K25	cxcr4_off	3.18667	0	1	1	0	1
1x25	NT.F29	cxcr4_off	3.11	0	0	0	2	1
E2.D181	E2.D182	Shared	3.10333	10.65	1	0	1	2
1x39	2x61	Shared	2.66667	2.67	1	1	1	2
5x33	Lig	cxcr4_off	2.61	0	0	0	1	0
1x35	2x64	Shared	2.10333	1.58	1	1	1	1
NT.E26	NT.P27	cxcr4_off	1.57	0	0	1	1	1
Lig	NT.S23	cxcr4_off	1.31667	0	1	1	0	1
6x55	6x59	cxcr4_off	1.03333	0	0	1	1	2
5x37	6x62	Shared	0.993333	4.47	0	0	2	1
1x39	Lig	cxcr4_on	0	4.05	1	1	1	0
7x42	Lig	cxcr4_on	0	5.78	1	1	1	0
6x51	Lig	cxcr4_on	0	3.79	0	1	1	0
6x55	Lig	cxcr4_on	0	4.61	0	1	1	0
1x35	Lig	cxcr4_on	0	4.27	1	1	1	0
7x35	Lig	cxcr4_on	0	4.89	0	1	1	0
6x64	Lig	cxcr4_on	0	11.65	0	0	1	0
E2.I185	Lig	cxcr4_on	0	8.47	0	1	1	0
NT.E26	NT.K25	cxcr4_on	0	9.45	0	1	1	1
NT.F29	NT.P27	cxcr4_on	0	8.67	1	1	1	1
7x27	NT.C28	cxcr4_on	0	6.08	1	0	1	2
1x24	7x31	cxcr4_on	0	15.8	1	0	1	1
1x31	7x31	cxcr4_on	0	3.83	1	1	2	1
1x31	7x35	cxcr4_on	0	5.96	1	1	2	1
2x56	2x60	cxcr4_on	0	6.06	0	0	2	1
2x60	3x28	cxcr4_on	0	4.9	1	1	1	2
3x25	3x29	cxcr4_on	0	4.42	1	1	2	1
5x37	6x59	cxcr4_on	0	4.85	0	0	2	2
5x40	6x58	cxcr4_on	0	5.22	0	0	1	1
5x40	6x59	cxcr4_on	0	5.78	0	0	1	2
5x43	6x51	cxcr4_on	0	4.36	0	1	2	1
6x51	6x52	cxcr4_on	0	8.94	0	1	1	2
7x24	7x28	cxcr4_on	0	4.72	0	0	2	2
2x53	3x36	cxcr4_on	0	3.65	1	1	2	2
Lig	NT.E26	cxcr4_on	0	3.49	1	1	0	1
7x30	7x34	cxcr4_on	0	3.07	0	0	2	2
5x44	6x55	cxcr4_on	0	2.94	0	0	2	1
1x35	1x36	cxcr4_on	0	1.64	1	1	1	2
2x64	Lig	cxcr4_on	0	1.58	0	1	1	0
5x33	E2.N192	cxcr4_on	0	1.35	0	0	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	cxcr4_off	4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
	cxcr4_on	8K3Z-CXCR4-CXCL12-Gi1/β1/γ1

Network Difference
Value	cxcr4_off	cxcr4_on
I_min	3.37667	3.72
Number of Linked Nodes	277	271
Number of Specific Nodes	18 (6.50%)	12 (4.43%)
Number of Shared Nodes	259 (93.50%)	259 (95.57%)
Number of Links	307	301
Number of Specific Links	134 (43.65%)	128 (42.52%)
Number of Shared Links	173 (56.35%)	173 (57.48%)
Number of Hubs	37	34
Number of Specific Hubs	14 (37.84%)	11 (32.35%)
Number of Shared Hubs	23 (62.16%)	23 (67.65%)
Average % Shared Neighbours (Jaccard)	42.17
Average % Shared Neighbours (Otsuka)	50.20
Average % Shared Neighbours (Overlap Coefficient)	57.24
Average % Shared Cliques (k3-6)	55.00
Graphlets Similarity	0.590992

Paths Difference
Value	cxcr4_off	cxcr4_on
Number Of Nodes in MetaPath	58	65
Specific Nodes in MetaPath	27 (46.55%)	34 (52.31%)
Shared Nodes in MetaPath	259 (93.50%)	259 (93.50%)
Number Of Links MetaPath	60	64
Specific Links in MetaPath	45 (75.00%)	49 (76.56%)
Shared Links in MetaPath	173 (56.35%)	173 (56.35%)
Number of Shortest Paths	51614	46494
Length Of Smallest Path	3	3
Average Path Length	13.2477	12.7222
Length of Longest Path	28	30
Minimum Path Strength	0.618333	1.36
Average Path Strength	6.46723	6.35879
Maximum Path Strength	17.2583	17.1333
Minimum Path Correlation	0.703333	0.71
Average Path Correlation	0.931811	0.950729
Maximum Path Correlation	0.986667	0.99
Minimum % Of Corr. Nodes	4.34783	4.7619
Average % Of Corr. Nodes	50.0319	60.5992
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	45.6622	39.9077
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download cxcr4_off_on.zip<

You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.

You can also read or download a guide explaining the meaning of all files and numerical data.