Orange: nodes, hubs and links specific of cxcr4_on_gp network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of cxcr4_off network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.


Index Hub Owner cxcr4_on_gp Avg Int. Strength cxcr4_off Avg Int. Strength cxcr4_on_gp Num Of Links cxcr4_off Num Of Links ConSurf
1G.HN.37 cxcr4_on_gp3.74750403
2G.S1.02 cxcr4_on_gp4.9420505
3G.S1.05 cxcr4_on_gp5.6350409
4G.H1.01 cxcr4_on_gp5.0480509
5G.S2.08 cxcr4_on_gp8.1150403
6G.S3.01 cxcr4_on_gp4.83250403
7G.S3.02 cxcr4_on_gp7.89250404
8G.S3.03 cxcr4_on_gp9.430404
9G.S3.04 cxcr4_on_gp11.0450407
10G.S3.06 cxcr4_on_gp6.0080507
11G.s3h2.03 cxcr4_on_gp5.1320509
12G.H2.04 cxcr4_on_gp3.90409
13G.H2.06 cxcr4_on_gp6.1550608
14G.H2.07 cxcr4_on_gp4.6880509
15G.H2.09 cxcr4_on_gp6.07250408
16G.h2s4.01 cxcr4_on_gp6.3360507
17G.s4h3.04 cxcr4_on_gp8.58750408
18G.s4h3.05 cxcr4_on_gp10.15750408
19G.s4h3.14 cxcr4_on_gp4.540404
20G.H3.09 cxcr4_on_gp6.060509
21G.H3.13 cxcr4_on_gp4.350508
22G.H3.14 cxcr4_on_gp7.9150405
23G.H3.17 cxcr4_on_gp7.611670604
24G.S5.03 cxcr4_on_gp2.8950406
25G.S5.05 cxcr4_on_gp6.9140509
26G.S5.06 cxcr4_on_gp4.620509
27G.HG.04 cxcr4_on_gp4.2250406
28G.HG.08 cxcr4_on_gp3.22250409
29G.hgh4.01 cxcr4_on_gp4.71750403
30G.hgh4.02 cxcr4_on_gp6.8150606
31G.hgh4.05 cxcr4_on_gp8.91750406
32G.H4.03 cxcr4_on_gp4.958330605
33G.H4.15 cxcr4_on_gp5.3950405
34G.h4s6.02 cxcr4_on_gp7.15250404
35G.S6.02 cxcr4_on_gp6.8340505
36G.S6.03 cxcr4_on_gp6.82750407
37G.s6h5.01 cxcr4_on_gp8.60504
38G.H5.08 cxcr4_on_gp5.6150408
39G.H5.25 cxcr4_on_gp5.02750408
40b.h2x4 cxcr4_on_gp3.0950403
41b.h2x5 cxcr4_on_gp3.30505
42b.lhb1x6 cxcr4_on_gp4.22750403
43b.lhb1x11 cxcr4_on_gp3.7150404
44b.b1x4 cxcr4_on_gp6.160407
45b.l1x3 cxcr4_on_gp8.9020509
46b.b2x1 cxcr4_on_gp8.8240508
47b.b2x5 cxcr4_on_gp5.670607
48b.l3x2 cxcr4_on_gp6.06250409
49b.b4x2 cxcr4_on_gp4.660408
50b.b4x5 cxcr4_on_gp4.3150407
51b.b4x6 cxcr4_on_gp10.07670609
52b.b5x2 cxcr4_on_gp6.2950407
53b.b5x3 cxcr4_on_gp5.948330609
54b.b5x5 cxcr4_on_gp4.94250405
55b.b5x7 cxcr4_on_gp5.04750407
56b.l5x1 cxcr4_on_gp4.9180508
57b.l5x5 cxcr4_on_gp6.2550809
58b.b6x5 cxcr4_on_gp3.90706
59b.b7x1 cxcr4_on_gp6.12250404
60b.b7x4 cxcr4_on_gp4.12250408
61b.b8x4 cxcr4_on_gp5.9540506
62b.l8x1 cxcr4_on_gp4.1850405
63b.l8x3 cxcr4_on_gp5.19250403
64b.l9x3 cxcr4_on_gp5.970609
65b.l9x6 cxcr4_on_gp5.18301008
66b.b10x5 cxcr4_on_gp4.168570709
67b.l10x1 cxcr4_on_gp4.23250403
68b.b11x3 cxcr4_on_gp3.590405
69b.b11x4 cxcr4_on_gp5.44250409
70b.l11x2 cxcr4_on_gp9.24750409
71b.b12x6 cxcr4_on_gp8.606670608
72b.b13x3 cxcr4_on_gp6.820404
73b.b13x7 cxcr4_on_gp7.7920507
74b.l13x3 cxcr4_on_gp8.880509
75b.b15x1 cxcr4_on_gp7.30750409
76b.b15x2 cxcr4_on_gp5.1750406
77b.l15x2 cxcr4_on_gp6.32750409
78b.b16x4 cxcr4_on_gp9.60506
79b.b16x6 cxcr4_on_gp10.4220508
80b.b17x7 cxcr4_on_gp6.96250408
81b.l17x3 cxcr4_on_gp8.396670609
82b.l17x6 cxcr4_on_gp7.17750409
83b.b18x3 cxcr4_on_gp4.70750408
84b.b18x5 cxcr4_on_gp5.09750405
85b.l18x1 cxcr4_on_gp6.526670606
86b.b19x2 cxcr4_on_gp6.6780506
87b.b19x4 cxcr4_on_gp5.6150408
88b.l19x2 cxcr4_on_gp6.620509
89b.b20x4 cxcr4_on_gp10.7420508
90b.b20x6 cxcr4_on_gp6.9440506
91b.b21x1 cxcr4_on_gp6.2640507
92b.b21x2 cxcr4_on_gp4.3250406
93b.b21x5 cxcr4_on_gp8.04250404
94b.b21x7 cxcr4_on_gp7.2920505
95b.l21x5 cxcr4_on_gp3.930504
96b.l22x5 cxcr4_on_gp7.3780509
97b.b23x6 cxcr4_on_gp6.924290707
98b.b24x4 cxcr4_on_gp8.5720506
99b.b24x6 cxcr4_on_gp4.97250408
100b.b25x3 cxcr4_on_gp7.01750405
101b.l25x3 cxcr4_on_gp8.6180509
102b.l26x5 cxcr4_on_gp6.9950405
103b.l27x1 cxcr4_on_gp11.69140709
104b.l27x2 cxcr4_on_gp4.6950409
105b.b28x2 cxcr4_on_gp4.10750404
106b.b28x3 cxcr4_on_gp4.5650407
107b.b28x4 cxcr4_on_gp7.35250406
108b.b28x6 cxcr4_on_gp8.251670609
109b.b28x7 cxcr4_on_gp7.3950409
110g.h1x8 cxcr4_on_gp2.64250407
111g.h1x15 cxcr4_on_gp2.7350408
112g.l1x4 cxcr4_on_gp8.18250408
113g.ctx3 cxcr4_on_gp6.1620509
114g.ctx6 cxcr4_on_gp3.3380506
115g.ctx16 cxcr4_on_gp4.911670608
1161x34 cxcr4_on_gp4.963.965425
1171x57 cxcr4_on_gp4.11754.9436
1182x43 cxcr4_on_gp6.547517.2583428
1193x25 cxcr4_on_gp5.745.30778439
1203x38 cxcr4_on_gp4.2183.24833527
1213x42 cxcr4_on_gp3.73253.91667427
1223x46 cxcr4_on_gp4.70755.1428
1234x49 cxcr4_on_gp4.7164.15833527
1244x61 cxcr4_on_gp7.82258.92556434
125E2.N192 cxcr4_on_gp4.6956.17667421
1265x58 cxcr4_on_gp6.472863.02738
1276x40 cxcr4_on_gp5.46253.23427
1286x52 cxcr4_on_gp8.4488.35445538
1297x31 cxcr4_on_gp9.83754.2434
1307x46 cxcr4_on_gp4.1954.66333439
1318x50 cxcr4_on_gp6.642.85667518
132Lig Shared49.980822.859325240
1331x35 Shared3.7154.34583646
1341x39 Shared4.9855.27133457
1351x50 Shared5.016.25583449
1362x38 Shared4.86254.32667446
1372x42 Shared7.24755.45457
1382x53 Shared4.9988.5775547
1392x60 Shared11.94757.71333457
140E1x50 Shared8.4787.03238579
141E1x52 Shared10.358.64333447
1423x29 Shared5.76756.05667446
1433x32 Shared7.3367.20167566
1443x35 Shared4.956.2875448
1453x37 Shared6.34755.7675447
1463x45 Shared3.6354.74267455
1473x50 Shared6.028333.71667649
1483x51 Shared7.96255.5725448
149I2x57 Shared7.56.994556
150E2.Y190 Shared8.058337.92867654
1515x35 Shared7.337.33733555
1525x39 Shared7.984.9075445
1536x48 Shared6.9347.98133559
1546x51 Shared7.897.8525647
1557x42 Shared7.4847.154557
1567x45 Shared6.447.7625449
1577x53 Shared5.286677.87417649
1581x30 cxcr4_off6.134.61333354
1591x47 cxcr4_off4.282.62583145
1603x49 cxcr4_off11.60337.57583348
1614x50 cxcr4_off8.216674.882359
162E2.R183 cxcr4_off4.836675.3125343
163E2x52 cxcr4_off10.43679.136355
1645x61 cxcr4_off4.371.9775248
1656x44 cxcr4_off6.066.86056369
1667x30 cxcr4_off3.793333.4075345
1677x38 cxcr4_off14.84677.57733355
1687x50 cxcr4_off4.4755.56333249
   
Orange: nodes, hubs and links specific of cxcr4_on_gp network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of cxcr4_off network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Owner cxcr4_on_gp Recurrence cxcr4_off Recurrence cxcr4_on_gp Hub1? cxcr4_off Hub1? cxcr4_on_gp Hub2? cxcr4_off Hub2? ConSurf1 ConSurf2
12x42 3x46 cxcr4_on_gp10.08452.8014YesYesYesNo78
23x47 5x58 cxcr4_on_gp95.86367.81213NoNoYesNo98
33x47 5x57 cxcr4_on_gp96.26755.873NoNoNoNo96
43x51 5x57 cxcr4_on_gp96.46120YesYesNoNo86
53x51 3x56 cxcr4_on_gp96.63674.46634YesYesNoNo86
63x56 I2x52 cxcr4_on_gp97.03783.00008NoNoNoNo65
7I2x51 I2x52 cxcr4_on_gp97.13331.50203NoNoNoNo55
8G.S3.01 I2x51 cxcr4_on_gp97.22860YesNoNoNo35
9G.S3.01 G.S3.03 cxcr4_on_gp96.18080YesNoYesNo34
10G.S2.06 G.S3.03 cxcr4_on_gp97.54380NoNoYesNo34
11G.H1.08 G.S2.06 cxcr4_on_gp97.63580NoNoNoNo93
12G.H1.08 G.H1.10 cxcr4_on_gp98.92430NoNoNoNo97
13G.H1.10 G.H1.12 cxcr4_on_gp99.01490NoNoNoNo77
14G.H1.12 G.S2.07 cxcr4_on_gp99.10540NoNoNoNo79
15G.S2.07 G.S3.02 cxcr4_on_gp99.19560NoNoYesNo94
16G.S3.02 G.S3.04 cxcr4_on_gp98.92820YesNoYesNo47
17G.S1.03 G.S3.04 cxcr4_on_gp99.91130NoNoYesNo97
18G.S1.03 G.S3.06 cxcr4_on_gp1000NoNoYesNo97
19G.S3.06 b.l5x5 cxcr4_on_gp54.21110YesNoYesNo79
20b.l3x1 b.l5x5 cxcr4_on_gp20.42270NoNoYesNo99
21b.b2x1 b.l3x1 cxcr4_on_gp19.82480YesNoNoNo89
22b.b2x1 b.l27x1 cxcr4_on_gp19.18580YesNoYesNo89
23b.b26x1 b.l27x1 cxcr4_on_gp11.8130NoNoYesNo99
24b.b26x1 b.b26x2 cxcr4_on_gp11.7220NoNoNoNo97
25b.b26x2 b.b2x3 cxcr4_on_gp11.63780NoNoNoNo76
26b.b2x3 b.b2x5 cxcr4_on_gp11.44880NoNoYesNo67
275x58 7x53 cxcr4_on_gp61.58360YesNoYesYes89
28G.H5.17 I3.Q233 cxcr4_on_gp10.2440NoNoNoNo65
29G.H5.26 I3.Q233 cxcr4_on_gp10.43250NoNoNoNo75
30G.H5.21 G.H5.26 cxcr4_on_gp10.62090NoNoNoNo97
318x49 G.H5.21 cxcr4_on_gp10.9970NoNoNoNo69
328x49 G.H5.22 cxcr4_on_gp11.18480NoNoNoNo65
332x37 G.H5.22 cxcr4_on_gp11.37240NoNoNoNo75
342x37 2x40 cxcr4_on_gp11.55991.50203NoNoNoNo78
352x40 2x43 cxcr4_on_gp11.72530NoNoYesNo88
362x43 8x50 cxcr4_on_gp12.8670YesNoYesNo88
371x53 8x50 cxcr4_on_gp14.34340NoNoYesNo88
381x53 2x47 cxcr4_on_gp14.71911.49805NoNoNoNo89
391x50 2x47 cxcr4_on_gp15.08732.67822YesYesNoNo99
402x50 7x49 cxcr4_on_gp50.26270NoNoNoNo99
412x46 7x53 cxcr4_on_gp53.54020NoNoYesYes99
42G.H2.07 G.h2s4.01 cxcr4_on_gp48.80380YesNoYesNo97
43G.H2.04 G.H2.07 cxcr4_on_gp19.1450YesNoYesNo99
44G.H2.04 G.H3.08 cxcr4_on_gp18.50570YesNoNoNo95
45G.H3.08 G.S4.04 cxcr4_on_gp18.3770NoNoNoNo57
46G.H3.09 G.S4.04 cxcr4_on_gp18.24420YesNoNoNo97
47G.H3.09 G.H4.15 cxcr4_on_gp16.44110YesNoYesNo95
48b.b10x1 b.b11x5 cxcr4_on_gp15.35480NoNoNoNo96
49b.b10x1 b.l9x6 cxcr4_on_gp15.53530NoNoYesNo98
50G.H2.07 b.l9x6 cxcr4_on_gp45.69730YesNoYesNo98
51G.H2.06 b.l9x6 cxcr4_on_gp74.89440YesNoYesNo88
52G.H2.06 b.l17x6 cxcr4_on_gp37.14870YesNoYesNo89
53G.H2.06 b.b18x1 cxcr4_on_gp37.15690YesNoNoNo89
54b.1x15 b.1x19 cxcr4_on_gp24.83910NoNoNoNo76
55b.1x15 g.h1x15 cxcr4_on_gp46.79480NoNoYesNo78
56b.1x11 g.h1x15 cxcr4_on_gp41.18530NoNoYesNo88
57b.1x11 g.h1x12 cxcr4_on_gp29.96150NoNoNoNo86
58g.h1x12 g.h1x8 cxcr4_on_gp28.09030NoNoYesNo67
59b.1x4 g.h1x8 cxcr4_on_gp14.98650NoNoYesNo87
60b.1x15 g.l1x4 cxcr4_on_gp23.95490NoNoYesNo78
61b.1x19 b.b21x1 cxcr4_on_gp30.46350NoNoYesNo67
62b.b21x1 g.l1x4 cxcr4_on_gp25.81090YesNoYesNo78
63b.l5x5 b.l7x2 cxcr4_on_gp40.31960YesNoNoNo99
64b.l11x1 b.l9x6 cxcr4_on_gp10.39970NoNoYesNo98
65b.b11x6 b.l11x1 cxcr4_on_gp10.1940NoNoNoNo99
66b.l17x6 b.l19x1 cxcr4_on_gp37.10560YesNoNoNo99
67b.l17x5 b.l19x1 cxcr4_on_gp73.80270NoNoNoNo69
68b.l17x5 b.l19x2 cxcr4_on_gp73.50350NoNoYesNo69
69b.l17x3 b.l19x2 cxcr4_on_gp50.4420YesNoYesNo99
70b.b19x4 b.l17x3 cxcr4_on_gp27.68160YesNoYesNo89
71b.b18x1 b.l19x1 cxcr4_on_gp37.00810NoNoNoNo99
72b.b19x4 b.b20x6 cxcr4_on_gp20.58680YesNoYesNo86
73b.b20x4 b.l17x3 cxcr4_on_gp21.53250YesNoYesNo89
74b.b20x4 b.b20x6 cxcr4_on_gp41.09310YesNoYesNo86
75b.b20x2 b.l19x2 cxcr4_on_gp22.15070NoNoYesNo69
76b.b20x2 b.b20x4 cxcr4_on_gp21.51950NoNoYesNo68
77b.b17x7 b.b20x6 cxcr4_on_gp58.82430YesNoYesNo86
785x58 6x41 cxcr4_on_gp23.47660YesNoNoNo87
795x55 6x41 cxcr4_on_gp23.31620NoNoNoNo47
805x55 6x45 cxcr4_on_gp23.01330NoNoNoNo44
816x44 6x45 cxcr4_on_gp22.70341.96297NoYesNoNo94
826x48 6x52 cxcr4_on_gp20.94278.63864YesYesYesNo98
836x51 6x52 cxcr4_on_gp17.22150YesYesYesNo78
846x51 Lig cxcr4_on_gp15.70950YesYesYesYes70
852x53 7x46 cxcr4_on_gp37.11790YesYesYesNo79
862x53 7x42 cxcr4_on_gp19.92729.55257YesYesYesYes77
877x42 Lig cxcr4_on_gp16.41480YesYesYesYes70
883x29 Lig cxcr4_on_gp10.52747.71279YesYesYesYes60
89b.b17x7 b.b21x1 cxcr4_on_gp57.44730YesNoYesNo87
90b.l7x2 b.l9x6 cxcr4_on_gp40.30230NoNoYesNo98
91G.S3.06 G.h2s4.01 cxcr4_on_gp45.70960YesNoYesNo77
921x50 2x50 Shared16.3706100YesYesNoNo99
932x46 7x49 Shared50.389179.3094NoNoNoNo99
946x44 6x48 Shared22.587119.2204NoYesYesYes99
952x50 7x46 Shared38.618626.4325NoNoYesNo99
962x53 3x32 Shared16.950153.8385YesYesYesYes76
973x32 Lig Shared16.426353.3895YesYesYesYes60
981x35 1x39 cxcr4_off2.7942311.2374YesYesYesYes67
996x51 7x38 cxcr4_off0.21113826.6113YesYesNoYes75
1007x38 Lig cxcr4_off0.014446723.8457NoYesYesYes50
101E1x49 E2.R183 cxcr4_off2.0077412.8308NoNoNoYes43
102E2.R183 Lig cxcr4_off014.8534NoYesYesYes30
1031x42 2x57 cxcr4_off012.9897NoNoNoNo78
1042x53 2x57 cxcr4_off014.2454YesYesNoNo78
1051x42 7x43 cxcr4_off0.66499811.7261NoNoNoNo75
1061x47 2x54 cxcr4_off012.5129NoYesNoNo56
1072x54 7x46 cxcr4_off0.79205816.6216NoNoYesNo69
1082x50 3x35 cxcr4_off083.9625NoNoYesYes98
1092x53 3x35 cxcr4_off064.9686YesYesYesYes78
1107x45 7x46 cxcr4_off0.7944829.222YesYesYesNo99
1113x35 7x45 cxcr4_off026.8378YesYesYesYes89
1126x48 7x45 cxcr4_off0.69030218.7555YesYesYesYes99
1136x48 6x51 cxcr4_off031.1889YesYesYesYes97
1141x50 7x50 cxcr4_off0.79098193.7535YesYesNoYes99
1152x43 7x53 cxcr4_off015.7792YesNoYesYes89
1162x43 7x49 cxcr4_off017.2097YesNoNoNo89
1177x49 7x50 cxcr4_off091.417NoNoNoYes99
1181x57 7x53 cxcr4_off010.1446YesNoYesYes69
1192x38 3x49 cxcr4_off1.7609812.4175YesYesNoYes68
1202x42 3x49 cxcr4_off4.2252745.7363YesYesNoYes78
1212x42 3x45 cxcr4_off3.4576167.77YesYesYesYes75
1223x45 4x49 cxcr4_off0.42245576.2378YesYesYesNo57
1233x42 4x49 cxcr4_off3.6480277.2908YesNoYesNo77
1242x46 3x42 cxcr4_off4.1153478.3041NoNoYesNo97
1253x49 I2x57 cxcr4_off2.1130818.4892NoYesYesYes86
1263x49 3x50 cxcr4_off015.4017NoYesYesYes89
1272x45 4x45 cxcr4_off0.49271410.1725NoNoNoNo95
1282x42 4x45 cxcr4_off021.7079YesYesNoNo75
1294x45 4x46 cxcr4_off0.48060110.1764NoNoNoNo57
1302x63 E1x50 cxcr4_off0.012562421.6363NoNoYesYes59
1312x63 Lig cxcr4_off021.4377NoNoYesYes50
132E2x52 Lig cxcr4_off022.0933NoYesYesYes50
1333x35 3x39 cxcr4_off015.215YesYesNoNo89
1343x40 6x44 cxcr4_off022.9675NoNoNoYes79
1353x40 5x50 cxcr4_off1.2295921.088NoNoNoNo79
1363x41 5x50 cxcr4_off019.2005NoNoNoNo59
1373x43 6x44 cxcr4_off036.0089NoNoNoYes89
1383x43 6x41 cxcr4_off021.1953NoNoNoNo87
1393x47 5x54 cxcr4_off0.30679115.505NoNoNoNo97
1405x54 6x41 cxcr4_off019.3038NoNoNoNo77
1413x51 3x52 cxcr4_off010.3711YesYesNoNo85
1423x52 I2x57 cxcr4_off0.35309214.6984NoNoYesYes56
143E2.Y190 E2x52 cxcr4_off0.030508611.5513YesYesNoYes45
1445x45 5x49 cxcr4_off0.82041313.4904NoNoNoNo46
1453x41 5x49 cxcr4_off015.4017NoNoNoNo56
1466x40 7x52 cxcr4_off0.8046211.6785YesNoNoNo77
1473x43 6x40 cxcr4_off013.5977NoNoYesNo87
1486x58 7x30 cxcr4_off013.0215NoNoNoYes55
1496x58 Lig cxcr4_off1.9941916.2481NoNoYesYes50
1503x39 6x44 cxcr4_off014.5037NoNoNoYes99
1516x44 7x45 cxcr4_off027.108NoYesYesYes99

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Midway



Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Node1Node2OwnerNet1LinkStrengthNet2LinkStrengthComm1Comm2Node1ShellNode2Shell
LigNT.M24cxcr4_off4.7301101
LigNT.P27Shared12.3813.381101
7x24NT.C28Shared4.853337.280022
LigNT.F29Shared4.811.731101
1x247x28cxcr4_off6.4266701112
1x24LigShared5.906673.21110
1x277x28Shared4.086674.090022
1x277x31Shared3.412.750021
1x301x31cxcr4_off4.0266701022
1x301x34Shared59.651022
1x311x35Shared4.576674.121121
1x351x39Shared6.643337.031111
1x392x60cxcr4_off6.7533301111
1x397x39cxcr4_off4.4466701112
1x397x42Shared5.846676.191111
2x533x32Shared5.166.191121
2x537x42Shared11.796.431121
2x563x28cxcr4_off4.2300022
2x603x32Shared8.683339.651111
2x607x38cxcr4_off5.8133301111
2x607x42cxcr4_off5.6801111
2x60LigShared11.636727.181110
2x63E1x50Shared5.583333.351012
2x63E2.R183Shared4.763338.341011
2x63Ligcxcr4_off12.456701010
E1x49E2.R183Shared6.833332.410021
3x25E1x50Shared5.223337.841122
3x28E1x50cxcr4_off4.0866700022
3x294x61Shared5.467.561112
3x294x65Shared7.316675.851112
3x29E2x52cxcr4_off5.2633301111
3x29LigShared6.186675.241110
3x323x36Shared9.383.521112
3x327x38cxcr4_off4.8633301111
3x327x42Shared5.846676.191111
3x365x43cxcr4_off4.2866700122
4x60E2x52Shared4.806677.210021
4x61E2x52Shared10.7210.721121
E2.F189E2.S178Shared4.406679.251111
E2.A180E2.I185Shared4.333331.620021
E2.D181Ligcxcr4_off8.9701010
E2.I185E2.R183Shared5.846673.760111
E2.R183Ligcxcr4_off3.8066701010
E2.I185E2x51cxcr4_off5.8366700111
E2.F189E2x51Shared5.113334.781111
E2x51LigShared8.9233312.391110
E2.Y190E2x52Shared13.7213.381121
5x36E2.Y190Shared4.206676.310022
5x436x52Shared4.3566710.890122
6x486x51cxcr4_off6.7533307021
6x486x52Shared5.466678.687022
6x516x55Shared9.266679.670111
6x517x37Shared4.163333.750112
6x517x38Shared11.226716.830111
6x587x30cxcr4_off3.4066701112
6x587x34Shared4.666674.21111
6x58LigShared9.745.961110
6x62LigShared6.876.071110
6x64E3.K271cxcr4_off6.7500012
7x27Ligcxcr4_off9.1266701010
7x31Ligcxcr4_off5.9466701110
7x387x42Shared6.6066712.831111
7x38LigShared9.3766714.881110
1x301x35cxcr4_off4.0601021
3x32LigShared9.2766711.131110
E2x52Ligcxcr4_off11.1701010
E2.F189LigShared10.973314.971110
5x40Ligcxcr4_off7.500010
7x247x27cxcr4_off3.5466700021
7x317x35Shared3.253336.971111
LigNT.K25cxcr4_off3.1866701101
1x25NT.F29cxcr4_off3.1100021
E2.D181E2.D182Shared3.1033310.651012
6x547x34cxcr4_off2.9400021
1x392x61Shared2.666672.671112
5x33Ligcxcr4_off2.6100010
1x352x64Shared2.103331.581111
NT.E26NT.P27cxcr4_off1.5700111
LigNT.S23cxcr4_off1.3166701101
6x556x59cxcr4_off1.0333300112
5x376x62Shared0.9933334.470021
1x39Ligcxcr4_on_gp04.051110
7x42Ligcxcr4_on_gp05.781110
6x51Ligcxcr4_on_gp03.790110
6x55Ligcxcr4_on_gp04.610110
7x34Ligcxcr4_on_gp03.070110
1x35Ligcxcr4_on_gp04.271110
7x35Ligcxcr4_on_gp04.890110
6x64Ligcxcr4_on_gp011.650010
E2.S178Ligcxcr4_on_gp03.560110
E2.I185Ligcxcr4_on_gp08.470110
LigNT.E26cxcr4_on_gp03.491101
NT.E26NT.K25cxcr4_on_gp09.450111
NT.F29NT.P27cxcr4_on_gp08.671111
7x27NT.C28cxcr4_on_gp06.081012
1x247x31cxcr4_on_gp015.81111
1x317x31cxcr4_on_gp03.831121
1x317x35cxcr4_on_gp05.961121
1x341x35cxcr4_on_gp03.650021
2x533x36cxcr4_on_gp03.651122
2x562x60cxcr4_on_gp06.060021
2x603x28cxcr4_on_gp04.91112
3x253x29cxcr4_on_gp04.421121
5x366x62cxcr4_on_gp02.980021
5x376x59cxcr4_on_gp04.850022
5x406x58cxcr4_on_gp05.220011
5x406x59cxcr4_on_gp05.780012
5x436x51cxcr4_on_gp04.360121
5x446x55cxcr4_on_gp02.940021
6x516x52cxcr4_on_gp08.940112
7x247x28cxcr4_on_gp04.720022
7x307x34cxcr4_on_gp03.070021
1x347x39cxcr4_on_gp02.770022
1x351x36cxcr4_on_gp01.641112
2x64Ligcxcr4_on_gp01.580110
5x33E2.N192cxcr4_on_gp01.350012

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
Id Description
cxcr4_on_gp 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
cxcr4_off 4RWS-CXCR4-vMIP-II
3OE0-CXCR4-CVX15
3OE6-CXCR4-IT1t
Network Difference
Value cxcr4_on_gp cxcr4_off
Imin 2.92 3.37667
Number of Linked Nodes 873 277
Number of Specific Nodes 609 (69.76%) 13  (4.69%)
Number of Shared Nodes 264 (30.24%) 264  (95.31%)
Number of Links 1064 307
Number of Specific Links 888 (83.46%) 131  (42.67%)
Number of Shared Links 176 (16.54%) 176  (57.33%)
Number of Hubs 157 37
Number of Specific Hubs 131 (83.44%) 11  (29.73%)
Number of Shared Hubs 26 (16.56%) 26  (70.27%)
Average % Shared Neighbours (Jaccard) 13.08
Average % Shared Neighbours (Otsuka) 15.94
Average % Shared Neighbours (Overlap Coefficient) 18.50
Average % Shared Cliques (k3-6) 51.62
Graphlets Similarity 0.625042
Paths Difference
Value cxcr4_on_gp cxcr4_off
Number Of Nodes in MetaPath 92 58
Specific Nodes in MetaPath 75 (81.52%) 41  (70.69%)
Shared Nodes in MetaPath 264 (30.24%) 264  (30.24%)
Number Of Links MetaPath 97 60
Specific Links in MetaPath 91 (93.81%) 54  (90.00%)
Shared Links in MetaPath 176 (16.54%) 176  (16.54%)
Number of Shortest Paths 1631301 51614
Length Of Smallest Path 3 3
Average Path Length 35.1643 13.2477
Length of Longest Path 69 28
Minimum Path Strength 1.275 0.618333
Average Path Strength 6.48068 6.46723
Maximum Path Strength 27.18 17.2583
Minimum Path Correlation 0.7 0.703333
Average Path Correlation 0.987842 0.931811
Maximum Path Correlation 1 0.986667
Minimum % Of Corr. Nodes 1.78571 4.34783
Average % Of Corr. Nodes 41.1423 50.0319
Maximum % Of Corr. Nodes 100 100
Minimum Path Hubs % 0 0
Average Path Hubs % 46.8653 45.6622
Maximum Path Hubs % 100 100

Details about the values in these tables can be found in the corresponding documentation page .

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download cxcr4_off_on_gp.zip<



You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.



You can also  read or  download a guide explaining the meaning of all files and numerical data.